CN115969930B - Pharmaceutical composition for chronic pharyngitis - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for chronic pharyngitis. The pharmaceutical composition contains ginseng, Ophiopogon japonicus, Pestifera stearata, Wood butterfly, raw licorice, lily, sucrose or rock sugar. It has the functions of nourishing yin and promoting fluid production, clearing away heat from deficiency, and relieving sore throat. It can be widely used in the prevention and treatment of chronic pharyngitis.

Description

Pharmaceutical composition for chronic pharyngitis

Technical field

The invention belongs to the field of medicine, and specifically relates to a pharmaceutical composition for chronic pharyngitis and a preparation method thereof.

Background technique

Chronic pharyngitis is a chronic inflammation of the throat mucosa. Pharyngeal pain, itching, hoarseness and foreign body sensation are its main clinical manifestations. It is affected by diet, excessive smoking and alcohol, excessive voice use, air quality and other diseases. , the incidence rate of chronic pharyngitis among residents in our country has reached about 20%, and it is easy to relapse and difficult to cure. Western medicine mostly uses antibiotics for clinical treatment, and some Chinese medicine even uses Chinese medicine containing antibacterial flavor for treatment. However, the effects are not ideal and have a serious impact on the patient's life and health.

Chronic pharyngitis belongs to the category of "throat obstruction" in traditional Chinese medicine and is a common disease among lung diseases. As early as in the "Huangdi Neijing", it has been recorded: "The knot of one yin and one yang results in laryngitis". "Introduction to Medicine" also points out: "Deficiency fire attacks upward, causing dryness and pain in the throat and diaphragm." "Taiping Shenghui Prescription" records: "If the wind and evil heat attack the spleen and lungs, the evil heat will attack and rush, and you will feel stagnation at noon, so you will have sore throat today." "Miscellaneous Diseases Sources of Rhinoceros Zhu·Volume 24" says: "Throat paralysis, if the paralysis is closed, the throat will be swollen, and the throat and nose will be blocked." Chronic pharyngitis is treated by most traditional Chinese medicine practitioners based on the interaction between yin deficiency and fire exuberance and phlegm, and is often treated with Medicines for clearing away heat, nourishing yin and clearing the lungs, such as the classic "Yin-Yin Qingfei Decoction" from Zheng Meijian's "Chonglou Jade Key" in the Qing Dynasty. It consists of raw rehmannia, ginseng, Ophiopogon japonicus, white peony root, licorice, paeonol, Fritillaria fritillary and mint. composition. Rehmannia glutinosa, Scrophulariaceae, and Ophiopogon japonicus are used to nourish the lungs and kidneys, so that metal and water can grow together, creating an inexhaustible spring; white peony root and licorice are used to nourish spleen yin, dispersing spleen essence, returning to the lungs, and spreading to the throat, so that the throat can be moistened with body fluids Nourishment will prevent dryness; paeonol bark clears away heat and cools the qi, Zhejiang clam clears away heat and resolves phlegm, mint is pungent and cool to dispel wind and dissipate stagnation. The whole prescription is cool but not cold, nourishes yin and clears the lungs, and is pungent and cool without being dispersed. Later generations of doctors often used the "Yangyin Qingfei Decoction" to treat chronic pharyngitis, and achieved certain results.

In addition, some scholars pointed out that most patients with chronic pharyngitis have a weak constitution. Chronic pharyngitis is caused by deficiency of internal organs, lack of nourishment in the throat, phlegm coagulation and blood stasis, and accumulation in the throat. Therefore, some scholars have used the method of strengthening the body and strengthening the body to treat chronic pharyngitis. Ginseng has become one of the candidate medicinal flavors for the treatment of chronic pharyngitis with the method of strengthening the body and strengthening the body because of its functions of tonifying vitality, rejuvenating the pulse and strengthening the pharyngitis, nourishing the spleen and lungs, producing body fluids and calming the nerves. However, in actual application, due to the excessive potency of ginseng, the treatment effect of chronic pharyngitis is poor, and the symptoms may even worsen. Based on the actual effect of ginseng in the treatment of chronic pharyngitis, some scholars choose ginseng leaves, ginseng whiskers, scrophulariaceae, and adenophora root to replace ginseng in the treatment of chronic pharyngitis. Although the corresponding substitution can effectively alleviate the adverse effects of excessive ginseng on the treatment of chronic pharyngitis, its effect of strengthening the root and strengthening the body is significantly weakened, and the therapeutic effect of chronic pharyngitis is still not ideal.

The present invention is dedicated to studying the application of ginseng in the treatment of chronic pharyngitis with the method of strengthening the body and strengthening the body, in order to effectively utilize ginseng to strengthen the body and treat chronic pharyngitis through a reasonable combination of medicinal flavors, and to avoid the adverse impact of the medicinal power of ginseng on the therapeutic effect of chronic pharyngitis. . This provides a pharmaceutical composition for chronic pharyngitis with precise curative effect.

Contents of the invention

The object of the present invention is to provide a pharmaceutical composition for chronic pharyngitis and a preparation method thereof.

On the one hand, the present invention provides a pharmaceutical composition for chronic pharyngitis, which is prepared from ginseng, Ophiopogon japonicus, Pomegranate stump, Licorice root, licorice, lily, sucrose or rock sugar.

Preferably, the pharmaceutical composition consists of 10-20 parts of Panax ginseng, 15-25 parts of Ophiopogon japonicus, 10-20 parts of Pleurotus striata, 5-15 parts of Wood Butterfly, 10-20 parts of raw licorice, 15-25 parts of Lily, and sucrose. Or it is prepared from 0-10 parts of rock sugar; more preferably, the pharmaceutical composition is prepared from 13-18 parts of ginseng, 18-22 parts of Ophiopogon japonicus, 13-18 parts of Pangda seaweed, 8-12 parts of Wood Butterfly, and 13 parts of raw licorice. -18 parts, 18-22 parts of lily, and 0-8 parts of sucrose or rock sugar; most preferably, the pharmaceutical composition is prepared from 15 parts of ginseng, 20 parts of Ophiopogon japonicus, 15 parts of Pestifera striata, 10 parts of Wood Butterfly, Prepared with 15 parts of raw licorice, 20 parts of lily, and 5 parts of sucrose or rock sugar;

Preferably, the ginseng is selected from white ginseng and roasted ginseng. More preferably, the roasted ginseng is fresh ginseng or white ginseng roasted at 100-150°C until the surface turns yellowish brown; more preferably, the roasted ginseng is Roasted ginseng is made by roasting fresh ginseng or white ginseng at 130°C until the surface turns yellowish brown.

Preferably, the pharmaceutical composition for chronic pharyngitis is a decoction, tea, tablet, capsule, oral liquid, etc.

Another object of the present invention is to provide a preparation method of a pharmaceutical composition for chronic pharyngitis, which includes the following steps:

(1) Material preparation: Weigh each raw material according to the formula;

(2) Preparation: Crush Ophiopogon japonicus, Pleurotus striata, Wood butterfly, raw licorice, lily, sucrose or rock sugar and pass through a 10-20 mesh sieve. Crush ginseng and pass through a 40-100 mesh sieve. Mix evenly and then pack. 10g, you can get a tea for preventing/treating chronic pharyngitis; add 5-15 times the amount of purified water such as ginseng, Ophiopogon japonicus, stout seaweed, wood butterfly, raw licorice, and lily, boil for 1-3 hours, filter, and filter the residue. Then add 3-8 times the amount of purified water and cook for 0.5-1.5 hours. Combine the two medicinal liquids to obtain a water decoction. Add crushed sucrose or rock sugar that has passed through a 10-20 mesh sieve. Stir evenly. Pack and sterilize. Ready to use. A water decoction for preventing/treating chronic pharyngitis; concentrate the water decoction to half of its original volume under reduced pressure, add optional flavoring agents, and then pack and sterilize to obtain an oral liquid for preventing/treating chronic pharyngitis; The water decoction is concentrated under reduced pressure to an extract with a relative density of 1.02-1.05 at 25°C, and sucrose or rock sugar that has been crushed and passed through a 10-20 mesh sieve and pharmaceutically acceptable excipients are added to prepare tablets and capsules, that is, Tablets and capsules are available for the prevention/treatment of chronic pharyngitis.

Another object of the present invention is to provide the use of ginseng, Ophiopogon japonicus, Pestria gigantea, Wood butterfly, raw licorice, lily, sucrose or rock sugar in the preparation of pharmaceutical compositions for chronic pharyngitis.

Preferably, 10-20 parts of ginseng, 15-25 parts of Ophiopogon japonicus, 10-20 parts of Pangasius, 5-15 parts of Butterfly, 10-20 parts of raw licorice, 15-25 parts of lily, 0-10 parts of sucrose or rock sugar ;More preferably, 13-18 parts of ginseng, 18-22 parts of Ophiopogon japonicus, 13-18 parts of Pangasius, 8-12 parts of Butterfly, 13-18 parts of raw licorice, 18-22 parts of lily, 0-20 sucrose or rock sugar 8 parts; the most preferred ones are 15 parts of ginseng, 20 parts of Ophiopogon japonicus, 15 parts of Pangasius, 10 parts of Butterfly, 15 parts of raw licorice, 20 parts of lily, and 5 parts of sucrose or rock sugar;

Preferably, the ginseng is selected from white ginseng and roasted ginseng. More preferably, the roasted ginseng is fresh ginseng or white ginseng roasted at 100-150°C until the surface turns yellowish brown; more preferably, the roasted ginseng is Roasted ginseng is made by roasting fresh ginseng or white ginseng at 130°C until the surface turns yellowish brown.

Beneficial effects of the invention

Through the selection of the ginseng processing method and the compatibility of its medicinal flavor, the present invention truly realizes the addition of ginseng with the functions of tonifying vitality, restoring pulse and consolidating pharyngitis, tonifying the spleen and lungs, producing body fluids and calming the nerves in the process of treating chronic pharyngitis. The therapeutic effect of chronic pharyngitis is improved. The pharmaceutical composition for chronic pharyngitis of the present invention has the functions of strengthening the body and strengthening the body, nourishing the spleen and lungs, nourishing yin and promoting fluid, clearing away heat and soothing the throat, etc., and can be widely used in chronic pharyngitis. prevention and treatment.

Detailed ways

The invention is described in more detail below to facilitate understanding of the invention.

Example 1: A decoction for chronic pharyngitis

15 parts of roasted ginseng, 20 parts of Ophiopogon japonicus, 15 parts of Pangasius, 10 parts of Wood Butterfly, 15 parts of raw licorice, 20 parts of lily, 5 parts of sucrose or rock sugar, of which roasted ginseng is raw sun-dried ginseng dried at 130℃ The surface turns yellowish brown. Prepare as follows:

(1) Material preparation: Weigh each raw material according to the formula;

(2) Preparation: Add 10 times the amount of purified water to the roasted ginseng, Ophiopogon japonicus, Pestria gracilis, Wood butterfly, raw licorice and lily, boil for 2 hours and then filter, add 5 times the amount of purified water to the filter residue and cook for 1 hour. Combine the two medicinal liquids to obtain a water decoction, add sucrose or rock sugar that has been crushed and passed through a 20-mesh sieve, stir evenly, pack and sterilize to obtain a water decoction for preventing/treating chronic pharyngitis.

Example 2: A decoction for chronic pharyngitis

15 parts of white ginseng, 20 parts of Ophiopogon japonicus, 15 parts of Pangasius, 10 parts of Wood Butterfly, 15 parts of raw licorice, 20 parts of lily, 5 parts of sucrose or rock sugar, and according to the method of Example 1, the formula for preventing/treating chronic pharyngitis is obtained Decoction.

Example 3: A tea for chronic pharyngitis

10 parts of white ginseng, 15 parts of Ophiopogon japonicus, 10 parts of Pestifera pectinifolia, 5 parts of Wood Butterfly, 10 parts of raw licorice, and 15 parts of lily, prepare according to the following method:

(1) Material preparation: Weigh each raw material according to the formula;

(2) Preparation: Crush Ophiopogon japonicus, Pleurotus striata, Wood butterfly, raw licorice, and lily and pass through a 20-mesh sieve. Crush white ginseng and pass through a 40-100 mesh sieve. Mix evenly and divide into packages. Each pack is 10g, ready for use. Tea for preventing/treating chronic pharyngitis.

Example 4: A capsule for chronic pharyngitis

15 parts of white ginseng, 20 parts of Ophiopogon japonicus, 15 parts of Pestifera pectinifolia, 10 parts of Wood Butterfly, 15 parts of raw licorice, 20 parts of lily, 5 parts of sucrose or rock sugar, prepare according to the following method:

(1) Material preparation: Weigh each raw material according to the formula;

(2) Preparation: Add 10 times the amount of purified water to white ginseng, Ophiopogon japonicus, Pestria gracilis, Wood Butterfly, raw licorice, and lily, boil for 2 hours and then filter, add 5 times the amount of purified water to the filter residue, boil for 1 hour, and combine The water decoction is obtained from two medicinal liquids. Concentrate the water decoction under reduced pressure to an extract with a relative density of 1.02-1.05 at 25°C. Add sucrose or rock sugar that has been crushed and passed through a 10-20 mesh sieve and pharmaceutically acceptable excipients. After granulation and filling in gelatin capsule shells, capsules for preventing/treating chronic pharyngitis are obtained.

Comparative Example 1: A water decoction

15 parts of red ginseng, 20 parts of Ophiopogon japonicus, 15 parts of Pestifera pectinifolia, 10 parts of Wood Butterfly, 15 parts of raw licorice, 20 parts of lily, and 5 parts of sucrose or rock sugar were prepared according to the method of Example 1 to obtain a decoction.

Comparative Example 2: A water decoction

15 parts of ginseng leaves, 20 parts of Ophiopogon japonicus, 15 parts of Pangasius, 10 parts of Butterfly, 15 parts of raw licorice, 20 parts of lily, and 5 parts of sucrose or rock sugar were prepared according to the method of Example 1 to obtain a decoction.

Comparative Example 3: A water decoction

15 parts of Panax ginseng, 20 parts of Ophiopogon japonicus, 15 parts of Pangasius, 10 parts of Butterfly, 15 parts of raw licorice, 20 parts of lily, and 5 parts of sucrose or rock sugar were prepared according to the method of Example 1 to obtain a decoction.

Comparative Example 4: A water decoction

15 parts of Scrophulariaceae, 20 parts of Ophiopogon japonicus, 15 parts of Pangasius, 10 parts of Wood Butterfly, 15 parts of raw licorice, 20 parts of Lily, and 5 parts of sucrose or rock sugar were prepared according to the method of Example 1 to obtain a decoction.

Comparative Example 5: A water decoction

15 parts of white ginseng, 20 parts of Ophiopogon japonicus, 15 parts of Pestifera sturgeon, 10 parts of Luo Han Guo, 15 parts of raw licorice, 20 parts of lily, and 5 parts of sucrose or rock sugar were prepared according to the method of Example 1 to obtain a decoction. Effect Example 1: Therapeutic effect of the pharmaceutical composition of the present invention on chronic pharyngitis

1.1 Experimental drugs:

The decoctions of Examples 1 and 2 and Comparative Examples 1-5.

1.2 Experimental methods

Fifty-four eight-week-old SD rats, weighing 300-320g, were randomly divided into 9 groups after adaptive feeding for one day, namely blank group, model group, Example 1-2 group and Comparative Example 1-5 group. Each group 6 rats. Rats other than the blank group were sprayed with 2.5% ammonia solution 0.03mL/100g body weight in the pharynx using an otolaryngology anesthesia sprayer. The rats in the blank group were sprayed with the same amount of normal saline twice a day for 14 consecutive days. Starting from the 7th day of ammonia spraying, intragastric administration was started once a day. The intragastric volume was 0.2g crude drug/100g body weight, and the intragastric volume was 0.4mL. The blank group and the model group were intragastrically administered with equal volumes of normal saline, and were continuously administered. After 14 days of gastric administration, femoral artery blood was taken from the rats 60 minutes after the last intragastric administration, and then the IL-1β content in the serum was measured. The rats were sacrificed by neck dissection, and the pharyngeal mucosa was observed.

1.3 Experimental results

The multi-factor analysis of variance module of the statistical software SPSS was used for data analysis. P<0.05 indicated that the difference was statistically significant.

On the second day of modeling, the model rats scratched their mouths, and the frequency and amount of water they drank increased significantly. On the fifth day of modeling, the pharyngeal mucosa of the model rats was obviously congested, and the mucosa was dark red, dry, and had poor gloss. After intragastric administration of the experimental drugs of Groups 1-2 of Examples and Groups 1-2 of Comparative Examples, the pharyngeal mucosa of the rats improved to a certain extent compared with the model group. The pharynx of rats in Group 1-2 of Examples was observed after the last administration. The pharyngeal mucosa of the rats in the model group was only slightly congested and the surface was smooth and moist. However, the pharyngeal congestion of the rats in the model group was severe and there were obvious ulcers.

Table 1 Effect of the pharmaceutical composition of the present invention on serum IL-1β content in rats with chronic pharyngitis

##, compared with the blank group, P<0.01; *, compared with the model group, P<0.05, **, compared with the model group, P<0.01.

IL-1β is the main secreted form of IL-1 and the main inflammatory factor that performs biological functions in the IL-1 family. Under normal physiological conditions, the content of serum IL-1β is very low. The experimental results in Table 1 show that through Ammonia was sprayed into the throat for 14 consecutive days. On the 7th day after the pharyngeal spray of ammonia was stopped, the serum IL-1β content of the rats in the model group was still significantly higher than that of the blank group. That is, the rats in the model group were sprayed into the throat for 14 consecutive days. He recovered on his own after 7 days. , there is still an obvious inflammatory response.

After intragastric administration of the water decoctions of Examples 1-2 and Comparative Examples 1-5 of the present invention, the serum IL-1β content of rats was significantly reduced compared with the model group, showing that the corresponding water decoctions have certain therapeutic effects on chronic pharyngitis. Among them, the therapeutic effect of the pharmaceutical compositions in Examples 1-2 of the present invention is the most obvious. After the roasted ginseng or white ginseng in the pharmaceutical composition of the present invention is replaced with red ginseng, ginseng leaves, ginseng whiskers or scrophulariaceae, the corresponding therapeutic effects are significantly reduced. The use has the functions of clearing away heat and moistening the lungs, soothing the throat and smoothing the throat. After Luo Han Guo, which has a bowel laxative effect, replaces the wood butterfly in the pharmaceutical composition of the present invention, its therapeutic effect is also significantly reduced, which shows that the compatibility of medicinal flavors of the pharmaceutical composition of the present invention has an important impact on the therapeutic effect of chronic pharyngitis.

The preferred embodiments of the present invention have been described above, but they are not intended to limit the present invention. Those skilled in the art may make modifications and changes to the embodiments disclosed herein without departing from the scope and spirit of the invention.

Claims (5)

1. A pharmaceutical composition for chronic pharyngitis, characterized in that the pharmaceutical composition consists of 13-18 parts of Panax ginseng, 18-22 parts of Ophiopogon japonicus, 13-18 parts of Pangda seaweed, and 8-12 parts of Wood butterfly, It is prepared from 13-18 parts of raw licorice, 18-22 parts of lily, and 0-8 parts of sucrose or rock sugar; the ginseng is selected from white ginseng and roasted ginseng; the roasted ginseng is prepared by mixing fresh ginseng or white ginseng in 100 Bake at -150℃ until the surface turns yellowish brown. 2. The pharmaceutical composition for chronic pharyngitis according to claim 1, characterized in that, the pharmaceutical composition consists of 15 parts of ginseng, 20 parts of Ophiopogon japonicus, 15 parts of Pangda seaweed, 10 parts of Licorice chinensis, and 15 parts of raw licorice. It is prepared with 20 parts of lily, 5 parts of sucrose or rock sugar. 3. The pharmaceutical composition for chronic pharyngitis according to any one of claims 1-2, characterized in that the pharmaceutical composition is a decoction, tea, tablet, capsule, or oral liquid. 4. The preparation method of the pharmaceutical composition for chronic pharyngitis according to any one of claims 1-2, characterized by comprising the following steps: (1) Material preparation: Weigh each raw material according to the formula; (2) Preparation: Crush Ophiopogon japonicus, Pleurotus striata, Wood butterfly, raw licorice, lily, sucrose or rock sugar and pass through a 10-20 mesh sieve. Crush ginseng and pass through a 40-100 mesh sieve. Mix evenly and then pack. 10g, you can get a tea for preventing/treating chronic pharyngitis; add 5-15 times the amount of purified water such as ginseng, Ophiopogon japonicus, stout seaweed, wood butterfly, raw licorice, and lily, boil for 1-3 hours, filter, and filter the residue. Then add 3-8 times the amount of purified water and cook for 0.5-1.5 hours. Combine the two medicinal liquids to obtain a water decoction. Add crushed sucrose or rock sugar that has passed through a 10-20 mesh sieve. Stir evenly. Pack and sterilize. Ready to use. A water decoction for the prevention/treatment of chronic pharyngitis; concentrate the water decoction under reduced pressure into an extract with a relative density of 1.02-1.05 at 25°C, add crushed sucrose or rock sugar that has passed through a 10-20 mesh sieve and pharmaceutically acceptable After the excipients are prepared into tablets and capsules, tablets and capsules can be obtained for preventing/treating chronic pharyngitis. 5. Use of the pharmaceutical composition for chronic pharyngitis according to claim 1 in the preparation of a pharmaceutical composition for chronic pharyngitis.