CN115919725B - Rose acne repairing composition, skin care preparation and application thereof - Google Patents
Rose acne repairing composition, skin care preparation and application thereof Download PDFInfo
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Abstract
The invention relates to the technical field of cosmetics, in particular to the field of IPC A61K8, and more particularly relates to a rose acne repairing composition, a skin care preparation and application thereof. The composition for repairing rose acne provided by the invention is prepared by compounding rice extract, acid bean seed polysaccharide, hydrolyzed algae extract, centella asiatica extract and green tea polyphenol, has definite targeting effect, and has obvious synergistic effect by repeated researches, so that the composition can achieve the synergistic promotion of moisturizing, relieving and repairing various effects. The active material raw materials and the raw materials of the skin care preparation in the efficacy composition are safe and easily obtained, and have good application prospect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to the field of IPC A61K8, and more particularly relates to a rose acne repairing composition, a skin care preparation and application thereof.
Background
Along with the development of modern society, pressure, pollution and climate change threaten skin health of people at all times, and the prevalence rate of skin diseases such as rose acne, seborrheic dermatitis, hormone-dependent dermatitis and the like is increasing in recent years. Among them, rose acne seriously afflicts people's life due to easy recurrence and long course of disease. According to the latest epidemiological data of all people in the world, the international prevalence rate of rose acne is 5.46 percent on average. The investigation result of 10095 community residents in the Changsha city in 2019 in China shows that the prevalence rate of rose acne in the area is 3.48%; epidemiological investigation of 9227 college students in the university of 2020 shows that the prevalence of rose acne is 3.4%.
The rose acne is well developed by young and middle-aged women of 20-50 years old, and the crowd is exactly coincident with the loving and skin care crowd, which affects the pursuit of health and beauty. The rose acne takes doctor orders as a main treatment principle in the outbreak period, but how to maintain skin health in the non-outbreak period, preventing the re-outbreak of the rose acne and assisting in repairing the skin of the rose acne are all the time pain spots which plague patients suffering from the rose acne. Therefore, the maintenance product which can prevent the acne skin of the Wei-Equipped rose and assist in maintaining the acne pre-skin of the rose is provided, and the maintenance product is a main technical problem to be solved at present.
The patent application document with the application number of CN202010142234.5 discloses a composition and a preparation for rose acne and a preparation method thereof, wherein 4-terpineol, a root extract of red-rooted salvia, a lilac extract, a chlorella extract, ceramide and cholesterol are selected as effective raw materials, and the effects of balancing skin microecology, reducing skin sensitivity, reducing skin inflammation, improving facial redness and pimple and repairing skin barrier are achieved through combined action. But its improvement is limited.
The patent document with the application number of CN202010361322.4 discloses an anti-acne cosmetic, which improves the anti-acne performance of the product by adding sweet wormwood extract and soybean extract, but does not obviously improve the stability of the product, and meanwhile, rose acne is different from acne in the aspects of prevention and treatment.
Disclosure of Invention
In order to solve the problems, the invention combines the forefront skin care concept and theoretical basis with the Chinese thousand years Chinese herbal medicine skin care experience, selects a plurality of plant compounds, and screens out the synergistic rose acne repairing composition through scientific proportioning and experimental verification. The invention provides a rose acne repairing composition, which is prepared from the following raw materials in parts by weight: 0.5-1.5 parts of rice (ORYZA SATIVA) extract, 0.1-0.5 part of sour bean (TAMARINDUS INDICA) seed polysaccharide, 0.7-1.2 parts of hydrolyzed algae extract, 0.05-0.5 part of centella asiatica (CENTELLA ASIATICA) extract and 0.1-0.2 part of green tea (CAMELLIASINENSIS) polyphenol.
Preferably, the rice extract is extracted from the embryo and bran of rice.
Preferably, the dry matter content of the rice extract is 15-35g/L, and the protein content is 2-8g/L; further preferably, the rice extract has a dry matter content of 17-32g/L and a protein content of 4-6g/L.
The rice extract was purchased from ERISIUM manufactured by SILAB s.a.
Preferably, the acid soybean seed polysaccharide comprises an acid soybean seed polysaccharide.
The acid legume polysaccharide was purchased from XILOGEL manufactured by Qihai Hua Du daily fragrance and flavor (Shanghai) Inc.
Preferably, the hydrolyzed algae extract comprises rhodocystis extract.
The rhodocyst algae extract was purchased from MARILIANCE manufactured by Qihai Hua Du daily fragrance and flavor (Shanghai) limited.
Preferably, the centella asiatica extract contains 50.0-70.0 wt% of madecassoside and 10.0-20.0 wt% of terminoloside, and the total content of three active substances reaches 70.0-90.0 wt%.
The centella asiatica extract was purchased from CENTEROX manufactured by Qihai Hua Du daily fragrance and flavor (Shanghai) limited.
Preferably, the green tea polyphenol is epigallocatechin gallate. The green tea polyphenols were purchased from EGCC manufactured by CIME bvba.
Preferably, the weight ratio of the rice extract to the rhodocystis extract is 1: (0.7-1.2).
Preferably, the weight ratio of the rice extract to the acid bean polysaccharide is 1: (0.1-0.5).
Preferably, the weight ratio of the rice extract to the centella asiatica extract is 1: (0.05-0.5).
Preferably, the weight ratio of the green tea polyphenol to the centella asiatica extract is 1: (0.5-5).
Endoplasmic reticulum stress plays an important role in the pathogenesis of rosacea. Endoplasmic reticulum stress is directly involved in the inflammatory response by activating transcription of different pathways of inflammatory genes. Modern literature demonstrates that IL-8 expression increases significantly in the presence of endoplasmic reticulum stress and UPR deficiency, thereby promoting centrosome infiltration. Infiltration of central granulocytes in the skin can lead to the formation of pustules of rosacea, affecting people's quality of life. Inhibition of IL-8 expression is therefore particularly important in the pathogenesis of rosacea.
The inventor creatively discovers that five active substances of rice, acid bean seeds, hydrolyzed algae (rhodosporidium), centella asiatica and green tea polyphenol are scientifically selected, and the expression of IL-8 is inhibited and the infiltration of centromere is inhibited by optimizing active substance components and scientific proportion; thereby relieving discomfort caused by the rose acne and assisting the treatment of the rose acne.
This is probably because the present inventors have preferred rice extracts with rice embryo and bran as extraction sites, which are both extraction sources, so that the rice extract prepared is rich in plant proteins, can maintain cellular protein homeostasis by maintaining the health of the endoplasmic reticulum, thus combating endoplasmic reticulum stress in cells, and in addition, can limit inflammation by inhibiting IL-8, optimize the internal structure of the skin, thus achieving the purpose of weakening endoplasmic reticulum stress.
In the invention, the acid bean seed polysaccharide is preferably used as one of the raw materials of the rose acne repairing composition, so that the instant moisturizing effect of the rose acne repairing composition can be improved, the beta-defensin 2 expression can be promoted, the antibacterial effect of the skin is improved, and the influence of hair follicle mites on the skin of the rose acne is further reduced.
In the invention, the rhodocyst algae extract is preferably used as one of the raw materials of the composition for repairing rose acne, and the related genes in the inflammatory process can be obviously inhibited by inhibiting TRPV1 activation, so that the reactions such as redness, burning and the like in the course of the rose acne are relieved.
The centella asiatica extract containing specific active ingredients is preferably used as one of the raw materials of the rose acne repairing composition, so that the expression of tumor necrosis factor alpha, interleukin-6, prostaglandin E2 and cyclooxygenase-1 can be inhibited, and the anti-inflammatory factor interleukin-10 is improved, thereby achieving the effects of healing wounds and improving skin disease symptoms. And it can also co-act with specific green tea polyphenols to further improve the anti-inflammatory and soothing efficacy of the composition and product stability.
The preparation method of the rose acne repairing composition comprises the following steps: mixing the raw materials uniformly in parts by weight.
The second aspect of the invention provides a skin care preparation containing the rose acne repair composition, which comprises the following preparation raw materials in percentage by weight: the rose acne repairing composition is 0.1-5%, the solvent is 2-10%, and the skin care preparation substrate is supplemented with the balance to 100%.
The skin care formulation matrix includes phase a, phase B and purified water 1.
The A phase comprises A-1 phase and A-2 phase.
The A-1 phase comprises the following raw materials in percentage by weight: 1-5% of softening agent and 0.2-1% of thickening agent.
Preferably, the emollient is one or more of tri (ethylhexanoate), caprylic/capric triglyceride, C12-13 alcohol lactate, polydimethylsiloxane, octyl polymethylsiloxane, isohexadecane, and squalane; it is further preferred that the composition of the present invention, is polydimethylsiloxane.
Preferably, the polydimethylsiloxane has a surface tension of 0.01-0.05N/m at 25 ℃ and a kinematic viscosity of 5-15mm 2/s at 25 ℃; the surface tension of the polydimethylsiloxane at 25 ℃ is 0.02N/m, and the kinematic viscosity at 25 ℃ is 10mm 2/s.
In some preferred embodiments, the polydimethylsiloxane is purchased from BELSIL DM, manufactured by Wake chemistry (China) Inc.
Preferably, the thickener is one or more of PEG-150 distearate, acrylic acid (ester) copolymer, carbomer and xanthan gum; further preferred are carbomers and acrylic acid (ester) based/C10-30 alkanol acrylate cross-linked polymers.
In some preferred embodiments, the carbomers are purchased from Lubrizol ADVANCED MATERIALS, incUltrez 30Polymer。
In some preferred embodiments, the acrylic/C10-30 alkanol acrylate cross-linked Polymer is purchased from PEMULEN TM TR-1Polymer manufactured by Lubrizol ADVANCED MATERIALS, inc.
Preferably, the weight ratio of the polydimethylsiloxane to the acrylic/C10-30 alkanol acrylate cross-linked polymer is (8-12): (0.9-1.1).
Preferably, the weight ratio of carbomer to acrylic acid (ester) based/C10-30 alkanol acrylate cross-linked polymer is (0.8-1.5): (1.7-2.8).
Preferably, the A-2 phase comprises the following raw materials in percentage by weight of the skin care preparation: 3-10% of humectant, 0.1-0.5% of skin conditioner, 0.05-0.2% of chelating agent and 3-7% of glycerin.
The humectant is one or more of glycerol, 1, 3-propylene glycol, allantoin, betaine, ceramide, hyaluronic acid, butanediol, 1, 2-pentanediol and glycereth-26; further preferred are hyaluronic acid and glycerol polyether-26.
Preferably, the weight ratio of the hyaluronic acid to the glycerolyether-26 is 1: (100-200); further preferably, the ratio is 1:150.
In some preferred embodiments, the hyaluronic acid is purchased from HYUNDAI BIOLAND co., ltd.
In some preferred embodiments, the glycerolyether-26 is purchased from VANTAGE SPECIALTY INGREDIENTS, inc., produced as LIPONICTM EG-1.
Preferably, the skin conditioner is one or more of hydroxyacetophenone, dipotassium glycyrrhizinate, allantoin, plant extract, fungus extract, ceramide and ascorbic acid; further preferred are p-hydroxyacetophenone and dipotassium glycyrrhizinate.
Preferably, the weight ratio of the p-hydroxyacetophenone to the dipotassium glycyrrhizinate is (1-2): (1-2).
Preferably, the chelating agent is disodium EDTA.
The raw materials of the phase B comprise the following components in percentage by weight: 0.1-1% of humectant, 0.01-0.7% of pH regulator and 2 1-3% of purified water.
Preferably, the humectant is one or more of glycerol, 1, 3-propylene glycol, panthenol, betaine, ceramide, sodium hyaluronate, butanediol, 1, 2-pentanediol, and glycereth-26; further preferred is panthenol.
Preferably, the pH regulator is one or more of citric acid, sodium citrate, polyglycerol-10, arginine, malic acid and succinic acid; further preferred are sodium citrate and arginine.
Preferably, the weight ratio of the sodium citrate to the arginine is (0.5-2): (1-5).
Preferably, the solvent is purified water and 1, 2-pentanediol.
Preferably, the weight ratio of the purified water to the 1, 2-pentanediol is (1-2): (1-2).
The skin care formulation matrix of the rose acne treatment composition of the present invention is not limited to the above-described ingredients within component a and component B, and other conventional skin conditioning agents may be added to meet product design requirements for better experience.
The skin care preparation containing the rose acne repairing composition contains the rose acne repairing composition of the invention in a scientific proportion, and also contains skin care auxiliary raw materials and other characteristic additives which are common in the industry, wherein the skin care auxiliary raw materials comprise, but are not limited to, common plant extracts, skin conditioning agents and other components, such as allantoin, phytosterol oleate, phytosterols, sodium hyaluronate, acetylated sodium hyaluronate, sodium hyaluronate crosslinked polymers, hydrolyzed sodium hyaluronate, ethylhexyl glycerol, ARTEMIA (ARTEMIA) extracts and other relevant raw materials.
The skin care preparation is only one of conventional preparations, and the rose acne repair composition can be applied to most conventional cosmetic preparations such as any water agent, essence, cream and the like from the viewpoint of product requirements.
The preparation method of the skin care preparation comprises the following steps:
pre-preparing 1: wetting hyaluronic acid and acid bean seed polysaccharide with glycerol in advance until the hyaluronic acid and the acid bean seed polysaccharide are uniformly dispersed for later use;
pre-preparing 2: dissolving sodium citrate and arginine in purified water 2 in advance until the sodium citrate and arginine are completely used;
Pre-preparing 3: dissolving and dispersing herba Centellae extract with solvent in advance until the herba Centellae extract is completely used;
pre-preparing 4: dissolving green tea polyphenols with solvent in advance until the green tea polyphenols are completely reserved;
S1: pre-weighing the A-1 component materials, adding the A-1 component materials into a water phase pot, stirring and wetting completely, adding purified water, and homogenizing for 5 minutes until the materials are uniformly dispersed;
s2: pre-weighing the A-2 component materials, adding the A-2 component materials into a water phase pot, starting stirring and heating, stirring and heating to 80-85 ℃, preserving moisture and stirring for 7-13min, adding the pre-prepared 1, homogenizing for 2-8min, and starting cooling and stirring;
s3: cooling to 60-70deg.C, adding the pre-prepared 2 and B component materials, rapidly stirring for 1-5min, stirring, mixing, and cooling;
s4: cooling to 40-50deg.C, adding pre-preparation 3, pre-preparation 4, red cyst algae extract and rice extract, and stirring to room temperature.
The third aspect of the invention provides application of the rose acne repair composition, which can be applied to conventional cosmetic preparations such as skin care preparations, body milks, body creams, aqua, cream, essence, bath cream and the like.
The beneficial effects are that:
1. The invention scientifically selects five active substances of rice, acid bean seeds, hydrolyzed algae (rhodocyst), centella asiatica and green tea polyphenol, and inhibits IL-8 expression and central granulocyte infiltration by optimizing active substance components and scientific proportion; thereby relieving discomfort caused by the rose acne and assisting the treatment of the rose acne.
2. In the multi-effect repairing composition provided by the invention, the rice extract with rice embryo and bran at the preferable extraction position can maintain the cell protein steady state by maintaining the health of the endoplasmic reticulum, so as to resist the endoplasmic reticulum stress in the cells.
3. According to the multi-effect repairing composition provided by the invention, the acid bean seed polysaccharide is preferably selected as one of the raw materials of the repairing composition for the rosacea, so that the instant moisturizing effect of the repairing composition for the rosacea can be improved, the expression of beta-defensin 2 can be promoted, the antibacterial effect of the skin is improved, and the influence of hair follicle mites on the skin of the rosacea is further reduced.
4. In the multi-effect repairing composition provided by the invention, the rhodocyst algae extract is preferably selected as the hydrolysis algae extract to be used as one of the raw materials of the rose acne repairing composition, and related genes in the inflammatory process can be obviously inhibited by inhibiting TRPV1 activation, so that reactions such as redness, burning and the like in the course of rose acne are relieved.
5. In the multi-effect repairing composition provided by the invention, the centella asiatica extract containing specific active ingredients is preferably selected as one of the raw materials of the rose acne repairing composition, so that the expression of tumor necrosis factor alpha, interleukin-6, prostaglandin E2 and cyclooxygenase-1 can be inhibited, and the anti-inflammatory factor interleukin-10 is improved, thereby achieving the effects of healing wounds and improving skin disease symptoms.
6. The composition for repairing rose acne provided by the invention is prepared by compounding rice extract, acid bean seed polysaccharide, hydrolyzed algae extract, centella asiatica extract and green tea polyphenol, has definite targeting effect, and has obvious synergistic effect by repeated researches, so that the composition can achieve the synergistic promotion of moisturizing, relieving and repairing various effects. The active material raw materials and the raw materials of the skin care preparation in the efficacy composition are safe and easily obtained, and have good application prospect.
Detailed Description
Specific examples of skin care formulations containing rose acne treatment compositions are shown in tables 1 and 2, each in weight percent. The raw material buyers in examples 1-9 and comparative examples 1-3 are all preferred manufacturers mentioned in the specification.
Wherein the rice chaff extracts of comparative example 1 and comparative example 2 were purchased from VINCIENCE TM VEGETAL CERAMIDES CC produced by ASHLAND LLC; the citrus fruit extracts of comparative example 2 and comparative example 3 were purchased from yufuning CALMNERV CR manufactured by Shanghai Jia Kai biotechnology Co.
The same preparation process is used for examples 1-9 and comparative examples 1-3, and the preparation method of the skin care preparation containing the rose acne treatment composition comprises the following steps:
pre-preparing 1: wetting hyaluronic acid and acid bean seed polysaccharide with 5% glycerol in advance until the hyaluronic acid and the acid bean seed polysaccharide are uniformly dispersed for later use;
pre-preparing 2: dissolving sodium citrate and arginine in 2% purified water in advance until the sodium citrate and arginine are completely used;
Pre-preparing 3: dissolving and dispersing centella asiatica extract with 1% warm purified water 3+1% pentanediol in advance until the centella asiatica extract is completely reserved;
Pre-preparing 4: dissolving green tea polyphenols with 2% purified water 4+2% pentanediol in advance until the green tea polyphenols are completely used;
S1: pre-weighing the A-1 component materials, adding the A-1 component materials into a water phase pot, stirring and wetting completely, adding purified water, and homogenizing for 5min until the materials are uniformly dispersed;
s2: pre-weighing the A-2 component materials, adding the A-2 component materials into a water phase pot, starting stirring and heating, stirring and heating to 85 ℃, preserving moisture and stirring for 10min, adding the pre-prepared 1, homogenizing for 5 min, and starting cooling and stirring;
s3: cooling to 65 ℃, adding the pre-prepared 2 and B component materials, rapidly stirring for 3min, and continuing stirring and cooling after stirring and mixing uniformly;
s4: cooling to 45deg.C, adding pre-preparation 3, pre-preparation 4, sargassum extract and rice extract (component C), and stirring to 25deg.C.
TABLE 1
TABLE 2
Performance test method
1. Centrifugal acceleration test
The skin care formulations prepared in examples 1 to 9 and comparative examples 1 to 3 were evaluated for whether the skin care formulations satisfied that the formulation system did not precipitate, did not separate out, did not delaminate the color of the botanical composition by a plurality of centrifugal acceleration tests, and specific parameters and results are shown in Table 3.
TABLE 3 Table 3
The results in Table 3 show that examples 1-8 and comparative examples 1-3 can be tested by accelerated centrifugation, showing that the rose acne treatment composition has good compatibility and stability, and can meet the needs of marketing. Example 9 the amount of added carob polysaccharide was outside the scope of the present application, affecting the stability of the rose acne repair composition and thus the stability of the skin care formulation.
2. Temperature stability
The skin care preparations prepared in examples 1 to 3, 8 and 10 to 12 were placed at-15℃and 42℃and room temperature (25 ℃) for 30 days, 60 days and 90 days, respectively, and whether the preparation system did not precipitate, did not separate out the plant composition color was observed, and the test results are shown in Table 4.
TABLE 4 Table 4
The results in Table 4 show that the examples 1-7 and the comparative examples 1-3 can maintain good stability at low temperature, normal temperature and high temperature, and can meet the market demands. The amount of centella asiatica extract added in example 8 is not within the scope of the present application, and thus affects the high and low temperature stability of the rosacea-repairing composition and the skin care formulation.
3. Efficacy experiment: relieving effect
Sodium dodecyl sulfonate (SLS) may trigger a stimulating reaction in the body after acting on the body, and the irritant enters the zebra fish body to induce inflammatory reaction, neutrophil cells generate immune response, migrate to the skin epidermis and aggregate. IL-8 is secreted by monocytes and vascular endothelial cells, and its level increases rapidly as inflammation occurs. Therefore, whether or not the sample has a soothing effect can be evaluated by detecting the relative expression amount of the IL-8 gene.
The experimental steps are as follows:
1. randomly selecting zebra fish in 6-hole plates, wherein each hole has 30 tails;
2. Water-soluble administration of SLS establishes a zebra fish skin inflammation model;
3. samples of examples 1-7 and comparative examples 10-12 were given water-soluble, respectively, with a 3mL per well capacity; three biological replicates;
Incubating for 18h at 4.28 ℃ in dark;
5. Extracting total RNA of zebra fish of each experimental group, synthesizing cDNA, and detecting gene expression of beta-actin and target genes by q-PCR;
6. the beta-actin is used as an internal reference of gene expression, the relative expression quantity of RNA of a target gene is calculated, and the calculation method is shown as the following formula:
RNA relative expression amount=2 ΔΔC(t)
Δc (t) =c (t) Target gene -C(t)β-actin; the results are shown in Table 5, which indicate that the lower the relative expression of IL-8 gene, the more significant the inhibition of IL-8 gene.
TABLE 5
As can be seen from Table 5, example 1 was mainly compared with comparative example 1, which mainly compared with comparative example 1, the difference in inhibition of IL-8 at different sites of rice was obtained by extracting rice embryo and bran from rice with rice extract; comparative example 1 the extraction site was rice chaff, and the results indicate that example 1 has a better inhibition rate against IL-8. Example 1 compared with comparative example 3, the difference in addition inhibition of IL-8 gene by two TRVP1 inhibitory feedstocks was mainly compared, and the result shows that the inhibition rate of IL-8 by example 1 was better. In examples 2-7, the amount of active added was outside the scope of the present application, thus affecting the IL-8 inhibition of skin care formulations containing rose acne treatment compositions.
Claims (6)
1. The rose acne repairing composition is characterized by comprising the following preparation raw materials in parts by weight: the preparation raw materials comprise the following components in parts by weight: 0.5-1.5 parts of rice extract, 0.1-0.5 part of acid bean seed polysaccharide, 0.7-1.2 parts of hydrolyzed algae extract, 0.05-0.5 part of centella asiatica extract and 0.1-0.2 part of green tea polyphenol; the hydrolyzed algae extract comprises rhodocystis extract;
The rice extract is extracted from rice embryo and bran;
the weight ratio of the rice extract to the hydrolyzed algae extract is 1:1, a step of;
the weight ratio of the rice extract to the acid bean seed polysaccharide is 1:0.2;
The weight ratio of the rice extract to the centella asiatica extract is 1:0.1.
2. A rosacea-repairing composition according to claim 1, characterized in that the dry matter content of the rice extract is 15-35g/L and the protein content is 2-8g/L.
3. A composition for repairing acne rosacea according to any one of claims 1 or 2, characterized in that said centella asiatica extract has a content of madecassoside and of terminoloside of 50.0-70.0% by weight, a content of asiaticoside of 10.0-20.0% by weight and a total content of three active substances of 70.0-90.0% by weight.
4. A skin care formulation comprising the rose acne repair composition according to any one of claims 1 to 3, characterized in that it is prepared from the following raw materials in weight percent: the rose acne repairing composition is 0.1-5%, the solvent is 2-10%, and the skin care preparation substrate is supplemented with the balance to 100%.
5. The skin care formulation of claim 4 wherein the skin care formulation matrix comprises phase a, phase B and purified water 1; the A phase comprises A-1 phase and A-2 phase.
6. Use of a rose acne repair composition according to any one of claims 1-3, for the preparation of conventional cosmetic formulations.
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| CN103237555A (en) * | 2010-02-19 | 2013-08-07 | 玫琳凯有限公司 | Topical skin care formulation |
| CN108685739A (en) * | 2018-07-25 | 2018-10-23 | 马凯 | It is a kind of repair skin barrier reduce acne skin matrix and its prepare with its cosmetics |
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| WO2015191449A2 (en) * | 2014-06-08 | 2015-12-17 | Solazyme, Inc. | Personal care products containing microalgae or extracts thereof |
| KR20180013659A (en) * | 2016-07-29 | 2018-02-07 | (주)동명바이오 | Cosmetic composition comprising the ozonized oil and femented extract of seaweed |
| CN110051601B (en) * | 2019-05-09 | 2021-12-10 | 伊犁弥玥泉生物科技有限公司 | Face-activating and repairing composition containing mineral spring water |
| CN111202769A (en) * | 2020-03-04 | 2020-05-29 | 云南贝泰妮生物科技集团股份有限公司 | Composition and preparation for acne rosacea and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103237555A (en) * | 2010-02-19 | 2013-08-07 | 玫琳凯有限公司 | Topical skin care formulation |
| CN108685739A (en) * | 2018-07-25 | 2018-10-23 | 马凯 | It is a kind of repair skin barrier reduce acne skin matrix and its prepare with its cosmetics |
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