CN115856040A - Blood sugar detection device - Google Patents

Abstract

The application discloses blood sugar detection device, including the body and the electrochemical sensor who is connected with the body electricity. The electrochemical sensor outputs an electric signal based on glucose in the parotid gland saliva; the body is internally provided with a signal processing circuit which is connected with the electrochemical sensor through an electrode joint arranged on the body and used for processing the electric signal to obtain and output the blood sugar value. The detection device can obtain the blood sugar value of a user without a blood sample, and the user does not need to puncture the skin to take blood, so that the wound of a patient is avoided.

Description

A blood sugar detection device

technical field

The present application relates to the technical field of medical devices, and more specifically, to a blood glucose detection device.

Background technique

Diabetes mellitus is an endocrine disorder that can lead to abnormal blood sugar levels. It has a high incidence and a heavy disease burden, and is an important public health problem worldwide. Abnormal blood sugar levels can cause various complications such as cardiovascular disease, chronic kidney disease, blindness, stroke, diabetic foot, bacterial infection, etc., and cannot be cured, and can only be controlled by drugs based on blood sugar levels. Therefore, it is necessary to monitor blood sugar levels. Check frequently. Conventional blood glucose testing is achieved by collecting venous blood or fingertip blood, because blood collection requires the use of a blood collection needle to puncture a vein or fingertip, thereby causing trauma to the patient.

Contents of the invention

In view of this, the present application provides a blood glucose detection device for realizing blood glucose detection without causing trauma to the patient.

In order to achieve the above purpose, the proposed scheme is as follows:

A blood glucose detection device, comprising a body and an electrochemical sensor electrically connected to the body, wherein:

The electrochemical sensor outputs an electrical signal based on glucose in parotid saliva;

A signal processing circuit is arranged in the body, and the signal processing circuit is connected to the electrochemical sensor through the electrode joint arranged on the body, and is used for processing the electrical signal to obtain and output a blood glucose level.

Optionally, the electrochemical sensor includes connecting electrodes, and further includes a sampling layer, a detection layer, and a working electrode that are sequentially bonded together from top to bottom, wherein:

The connecting electrode is used to connect the electrode joint and connect with the working electrode;

The detection layer has a defect with a predetermined shape and a predetermined size, and the defect constitutes a detection chamber located between the working electrode and the sampling layer.

Optionally, the working electrode includes a base layer, a glucose enzyme sensing layer disposed on the base layer, and a polymer film layer disposed on the glucose enzyme sensing layer.

Optionally, the signal processing circuit includes a power supply circuit, a signal conditioning circuit, an analog-to-digital conversion circuit and a display element, wherein:

The power supply circuit is connected to the electrode joint, and is used to supply power to the electrochemical sensor through the electrode joint and the connecting electrode;

The signal conditioning circuit receives the electrical signal through the electrode joint and the connecting electrode, and processes the electrical signal to obtain an analog signal matching the working voltage of the analog-to-digital conversion circuit;

The analog-to-digital conversion circuit is connected to the signal circuit, and is used to perform analog-to-digital conversion on the analog signal to obtain a blood sugar level;

The display element is connected with the analog-to-digital conversion circuit for displaying the blood glucose value.

Optionally, the power supply circuit includes a power supply unit, a power supply circuit and a constant potential circuit, wherein:

The power supply circuit is respectively connected with the power supply unit and the constant potential circuit, and is used to supply power to the constant potential circuit based on the electric energy of the power supply unit;

The potentiostatic circuit is also connected to the electrode connector, and is used to output a constant voltage to the working electrode.

Optionally, the power supply circuit further includes a switching element provided on the body, wherein:

The switch element is used to output a start signal or a close signal to the power supply circuit when pressed by the user, the start signal is used to control the power supply circuit to start working, and the close signal is used to control the power supply circuit to stop power output .

Optionally, the signal conditioning circuit includes a weak current sampling circuit, a voltage range scaling circuit and a filter circuit, wherein:

The weak current sampling circuit is connected to the electrode connector, and is used to sample the electrical signal, and output the sampled electrical signal to the voltage range scaling circuit;

The voltage range scaling circuit is used to scale the voltage of the electrical signal and output it to the filter circuit;

The filter circuit is used to filter the electrical signal and output it to the analog-to-digital conversion circuit.

Optionally, the signal processing circuit also includes a wireless transmission module, wherein:

The wireless transmission module is connected with the analog-to-digital conversion circuit, and is used to send the blood glucose level to the user through wireless communication.

It can be seen from the above technical solutions that the present application discloses a blood glucose detection device, which includes a body and an electrochemical sensor electrically connected to the body. The electrochemical sensor outputs electrical signals based on the glucose in the parotid gland saliva; the main body is equipped with a signal processing circuit, and the signal processing circuit is connected to the electrochemical sensor through the electrode connector set on the main body to process the electrical signal to obtain and output the blood sugar value . The detection device can obtain the user's blood sugar level without a blood sample, and thus does not require the user to puncture the skin to collect blood, thereby avoiding causing trauma to the patient.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present application. Those skilled in the art can also obtain other drawings based on these drawings without creative work.

FIG. 1 is a schematic diagram of a blood glucose detection device according to an embodiment of the present application;

Fig. 2 is a side view of the blood glucose detection device of the embodiment of the present application;

Fig. 3 is the side view of the electrochemical sensor of the embodiment of the present application;

Fig. 4 is the exploded view of the electrochemical sensor of the embodiment of the present application;

FIG. 5 is a block diagram of a signal processing circuit of a blood glucose detection device according to an embodiment of the present application;

Fig. 6 is an example diagram of the results of saliva glucose detection by the blood glucose detection device according to the embodiment of the present application.

Detailed ways

The following will clearly and completely describe the technical solutions in the embodiments of the application with reference to the drawings in the embodiments of the application. Apparently, the described embodiments are only some of the embodiments of the application, not all of them. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of this application.

Example

FIG. 1 is a schematic diagram of a blood glucose detection device according to an embodiment of the present application.

As shown in Figure 1, the blood sugar detection device provided by this embodiment can detect the user's blood sugar by detecting the glucose in the user's saliva, and the device specifically includes a body for the user to grasp 10, and a detachable electrochemical sensor 20 connected to the body. The body is provided with an electrode joint 11. As shown in FIG. 2, the electrochemical sensor is connected to the electrode joint.

The electrochemical sensor is used to output an electrical signal to the body based on the glucose in the parotid saliva of the user applied thereto. In view of the strong correlation between the content of glucose in the parotid saliva and the blood sugar, the body processes the electrical signal to obtain The blood sugar level of the user is displayed, and the blood sugar level is displayed to the user, so as to realize the non-invasive blood sugar detection of the user.

The electrode connector is located at the front end of the body, and its exterior is protected by a detachable cover, which is convenient to take off or push away during measurement. A signal processing circuit is arranged inside the main body, and the signal processing circuit is used to process the electrical signal output by the electrochemical sensor to obtain and display the blood glucose level. The shape of the main body is curved, conforming to ergonomics, which is convenient for users to hold and fix at the detection position, and feels comfortable. Its front end has a certain radian, which is convenient for deep oral fixation and detection, and the angle range is 20-21 degrees.

The electrochemical sensor includes a sampling layer 21, a detection layer 22 and a working electrode 23 bonded together from top to bottom in sequence, as shown in FIG. There is a defect in the layer with a predetermined shape and a predetermined size, and the defect constitutes a detection chamber 221 between the working electrode and the sampling layer. An exploded view of the electrochemical sensor is shown in Figure 4.

The sampling layer can be a porous polymer film, its pore structure has specific size and distribution, has filtering and capillary action, the thickness is tens of microns, and can be adjusted according to the collection environment. The thickness of the porous polymer film in this example is 80 microns, and the diameter of the pores is 0.5 mm.

The detection layer is made of a biocompatible polymer film, which has a defect at the position between the sampling layer and the working electrode. The defect constitutes a specific pipeline structure, and the pipeline structure constitutes the detection chamber. The detection chamber The thickness can be adjusted according to the collection environment, from tens of microns to hundreds of microns. The detection chamber in this embodiment is a circular pipe with a diameter of 1 cm and a thickness of 800 microns.

The working electrode includes a base layer, a glucose enzyme sensing layer arranged on the base layer, and a polymer film layer arranged on the glucose enzyme sensing layer.

When bonding the sampling layer to the polymer film, wash it with isopropanol and deionized water successively, and dry it with nitrogen gas for surface treatment. The first step of surface treatment is surface activation (such as oxygen plasma treatment, etc.), and then coating a specific concentration of polymer solution (such as polyvinylpyrrolidone or polyethylene glycol, etc.), soaking for a certain period of time, and cleaning with deionized water , blow dry with nitrogen.

The electrochemical sensor of this embodiment is suitable for the size of the human oral cavity, is small and portable, is a disposable consumable, is easy to replace, and is sealed and packaged in a medical sterilization packaging bag. In this embodiment, the size of the electrochemical sensor is 0.5 x 0.25 x 0.5 mm.

The signal processing circuit 30 of the present application includes a power supply circuit 31, a signal conditioning circuit 32, an analog-to-digital conversion circuit 33 and a display element 34. As shown in FIG. The chemical sensor is powered; the signal conditioning circuit receives the electrical signal through the electrode connector and the connecting electrode, and processes the electrical signal to obtain an analog signal that matches the working voltage of the analog-to-digital conversion circuit.

The analog-to-digital conversion circuit is connected with the signal circuit, and is used for analog-to-digital conversion of the analog signal to obtain the blood sugar level; the display element is connected with the analog-to-digital conversion circuit, and is used for displaying the blood sugar level.

The power supply circuit includes a power supply unit, a power supply circuit, and a constant potential circuit. The power supply circuit is connected to the power supply unit and the constant potential circuit respectively, and is used to supply power to the constant potential circuit based on the electric energy of the power supply unit; the power supply circuit is composed of a voltage conversion chip, including a step-down Module, negative voltage conversion module, and power supply decoupling circuit, the function of this circuit is to provide a stable working voltage for the entire circuit system.

The potentiostatic circuit is also connected with the electrode joints for outputting a constant voltage to the working electrodes. The output voltage of the constant potential circuit is a certain constant voltage value in the range of -0.35V to -0.55V, and an ultra-low bias current integrated operational amplifier is used, and a voltage follower composed of an operational amplifier is connected to the feedback circuit. Ensure that the output impedance of the circuit is extremely low, ensure the voltage stability of the working electrode during the reaction process, and ensure that the electrode is not oxidized when it is energized.

The power supply circuit also includes a switch element 12 arranged on the body. The switch element is used to output an on signal or an off signal to the power supply circuit when pressed by the user. The on signal is used to control the power supply circuit to start working, and the off signal is used to control the power supply circuit to stop the power output. The switching element can serve as a test trigger button, by means of which the start of the test can be triggered.

The signal conditioning circuit includes a weak current sampling circuit, a voltage range scaling circuit and a filter circuit. The weak current sampling circuit is connected to the electrode connector for sampling the electrical signal, and outputs the sampled electrical signal to the voltage range scaling circuit; The current sampling circuit uses a high-precision operational amplifier to form a transimpedance amplifier, and the resistance value of the sampling resistor is set to 1MΩ, which realizes the function of amplifying the microampere-level current into a millivolt-level voltage, which is convenient for subsequent circuit-level analysis of the electrode current signal. deal with.

The voltage range scaling circuit is used to scale the voltage of the electrical signal and output it to the filter circuit; the voltage range scaling circuit is composed of an inverting operational amplifier. Since this part of the circuit does not require high precision, it uses a low-cost general-purpose integrated operational amplifier. The setting of this part of the circuit is to adjust the range of the amplified voltage signal obtained by the previous stage to the input range of the analog-to-digital conversion chip, to achieve an input close to the full scale, and to reduce the quantization noise generated by the analog-to-digital conversion chip.

The filtering circuit is used for filtering the electric signal and outputting it to the analog-to-digital conversion circuit. The structure of the filter circuit is a 4th-order Chebyshev low-pass filter. The cut-off frequency can be set to a specific value in the range of 5Hz to 25Hz. The specific value can be adjusted according to the use environment. The function of the filter circuit is to filter out the Thermal noise and other high frequency noise, while ensuring that the required signal voltage is not distorted.

The signal processing circuit also includes a wireless transmission module, which is connected with the analog-to-digital conversion circuit and is used to send the blood glucose level to the user through wireless communication, specifically, to the user's mobile device. The wireless transmission module can be realized by a Bluetooth wireless transmission module. The main body of the Bluetooth wireless transmission module is an ultra-low power consumption Bluetooth chip. The advantages of this type of chip are low power consumption and long battery life, and are especially suitable for the circuit part of the present invention. The function of this module is to wirelessly transmit the digital signal output by the analog-to-digital conversion circuit to the mobile terminal.

The present application provides a blood glucose detection device, which includes a body and an electrochemical sensor electrically connected to the body. The electrochemical sensor outputs electrical signals based on the glucose in the parotid gland saliva; the main body is equipped with a signal processing circuit, and the signal processing circuit is connected to the electrochemical sensor through the electrode connector set on the main body to process the electrical signal to obtain and output the blood sugar value . The detection device can obtain the user's blood sugar level without a blood sample, and thus does not require the user to puncture the skin to collect blood, thereby avoiding causing trauma to the patient.

The electrochemical sensor in this application is prepared by the following method:

Select biocompatible polydimethylsiloxane (PDMS), cross-link and cure to obtain a PDMS film (matrix to cross-linking agent weight ratio 10:1), stir for 10 minutes, and place it under vacuum at room temperature for 5 minutes to remove Bubbles, poured into a mold, and placed at 80 °C for 2 hours to obtain a PDMS film. According to the structural design, the detection chamber and the sampling flow channel are respectively manufactured, wherein the sampling flow channel can be constructed by a porous polymer film. Then rinse with isopropanol and deionized water, blow dry with nitrogen, treat the detection chamber and sampling flow channel with oxygen plasma for 45 seconds, then apply 10% polyvinylpyrrolidone solution, wait for 2 hours, and rinse with deionized water , blown dry with nitrogen to obtain a super-hydrophilic detection chamber and sampling channel. The newly obtained super-hydrophilic detection chamber, sampling flow channel and working electrode were subjected to oxygen plasma treatment for 45 seconds, and the three were irreversibly bonded.

The blood glucose detection device of the present application realizes blood glucose detection through the following steps:

After the subject rinses his mouth with warm water, he unpacks the blood glucose detection device and electrochemical sensor of the application, removes the protective cover on the head of the body, installs the electrochemical sensor at the position of the electrode joint, and then presses the detection trigger button to open it. Switch on the power, stick the electrochemical sensor on the submandibular gland of the oral cavity, and the time of each saliva collection lasts about 15-20s. For the detection results, turn off the power switch of the detection device, remove the used disposable electrochemical sensor, and cover the protective cover of the portable handheld device. The glucose content in saliva obtained through the above steps is shown in Figure 6.

Each embodiment in this specification is described in a progressive manner, each embodiment focuses on the difference from other embodiments, and the same and similar parts of each embodiment can be referred to each other.

Having described preferred embodiments of embodiments of the present invention, additional changes and modifications to these embodiments can be made by those skilled in the art once the basic inventive concept is appreciated. Therefore, the appended claims are intended to be construed to cover the preferred embodiment and all changes and modifications which fall within the scope of the embodiments of the present invention.

Finally, it should also be noted that the term "comprises", "comprises" or any other variation thereof is intended to cover a non-exclusive inclusion such that a process, method, article or terminal device comprising a set of elements includes not only those elements, It also includes other elements not expressly listed, or elements inherent in the process, method, article, or terminal equipment. Without further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of additional identical elements in the process, method, article or terminal device comprising said element.

The technical solution provided by the present invention has been introduced in detail above, and the principles and implementation methods of the present invention have been explained by using specific examples in this paper. The description of the above embodiments is only used to help understand the method and core idea of the present invention; At the same time, for those of ordinary skill in the art, according to the idea of the present invention, there will be changes in the specific implementation and application scope. In summary, the content of this specification should not be construed as limiting the present invention.

Claims (8)

1. A blood glucose detection device, characterized in that it comprises a body and an electrochemical sensor electrically connected to the body, wherein: The electrochemical sensor outputs an electrical signal based on glucose in parotid saliva; A signal processing circuit is arranged in the body, and the signal processing circuit is connected to the electrochemical sensor through the electrode joint arranged on the body, and is used for processing the electrical signal to obtain and output a blood glucose level. 2. The blood glucose detection device according to claim 1, wherein the electrochemical sensor comprises connecting electrodes, and further comprises a sampling layer, a detection layer and a working electrode bonded together sequentially from top to bottom, wherein: The connecting electrode is used to connect the electrode joint and connect with the working electrode; The detection layer has a defect with a predetermined shape and a predetermined size, and the defect constitutes a detection chamber located between the working electrode and the sampling layer. 3. The blood glucose detection device according to claim 2, wherein the working electrode comprises a base layer, a glucose enzyme sensing layer disposed on the base layer, and a glucose enzyme sensing layer disposed on the glucose enzyme sensing layer. polymer film layer. 4. The blood glucose detection device according to claim 1, wherein the signal processing circuit comprises a power supply circuit, a signal conditioning circuit, an analog-to-digital conversion circuit and a display element, wherein: The power supply circuit is connected to the electrode joint, and is used to supply power to the electrochemical sensor through the electrode joint and the connecting electrode; The signal conditioning circuit receives the electrical signal through the electrode joint and the connecting electrode, and processes the electrical signal to obtain an analog signal matching the working voltage of the analog-to-digital conversion circuit; The analog-to-digital conversion circuit is connected to the signal circuit, and is used to perform analog-to-digital conversion on the analog signal to obtain a blood sugar level; The display element is connected with the analog-to-digital conversion circuit for displaying the blood glucose value. 5. The blood glucose detection device according to claim 6, wherein the power supply circuit comprises a power supply unit, a power supply circuit and a constant potential circuit, wherein: The power supply circuit is respectively connected with the power supply unit and the constant potential circuit, and is used to supply power to the constant potential circuit based on the electric energy of the power supply unit; The potentiostatic circuit is also connected to the electrode connector, and is used to output a constant voltage to the working electrode. 6. The blood glucose detection device according to claim 7, wherein the power supply circuit further comprises a switch element disposed on the body, wherein: The switch element is used to output a start signal or a close signal to the power supply circuit when pressed by the user, the start signal is used to control the power supply circuit to start working, and the close signal is used to control the power supply circuit to stop power output . 7. The blood glucose detection device according to claim 6, wherein the signal conditioning circuit comprises a weak current sampling circuit, a voltage range scaling circuit and a filter circuit, wherein: The weak current sampling circuit is connected to the electrode connector, and is used to sample the electrical signal, and output the sampled electrical signal to the voltage range scaling circuit; The voltage range scaling circuit is used to scale the voltage of the electrical signal and output it to the filter circuit; The filter circuit is used to filter the electrical signal and output it to the analog-to-digital conversion circuit. 8. The blood glucose detection device according to claim 6, wherein the signal processing circuit further comprises a wireless transmission module, wherein: The wireless transmission module is connected with the analog-to-digital conversion circuit, and is used to send the blood glucose level to the user through wireless communication.

Images