CN115843812B - Insecticidal and acaricidal composition containing spiromesifen and application thereof - Google Patents
Insecticidal and acaricidal composition containing spiromesifen and application thereof Download PDFInfo
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- CN115843812B CN115843812B CN202211662072.3A CN202211662072A CN115843812B CN 115843812 B CN115843812 B CN 115843812B CN 202211662072 A CN202211662072 A CN 202211662072A CN 115843812 B CN115843812 B CN 115843812B
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- insecticidal
- acaricidal composition
- spiromesifen
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- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 title claims abstract description 61
- 239000005665 Spiromesifen Substances 0.000 title claims abstract description 60
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 230000000895 acaricidal effect Effects 0.000 title claims abstract description 47
- 230000000749 insecticidal effect Effects 0.000 title claims abstract description 46
- 150000001875 compounds Chemical class 0.000 claims abstract description 57
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 24
- 241000238876 Acari Species 0.000 claims abstract description 21
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 19
- 239000004480 active ingredient Substances 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims description 48
- 241001454295 Tetranychidae Species 0.000 claims description 13
- 239000007787 solid Substances 0.000 claims description 11
- 241000526125 Diaphorina citri Species 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 239000000375 suspending agent Substances 0.000 claims description 10
- 241001414857 Psyllidae Species 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 239000004563 wettable powder Substances 0.000 claims description 6
- 241001466030 Psylloidea Species 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000002270 dispersing agent Substances 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 239000000080 wetting agent Substances 0.000 claims description 3
- 239000002518 antifoaming agent Substances 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000002562 thickening agent Substances 0.000 claims description 2
- 241000239290 Araneae Species 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000000575 pesticide Substances 0.000 abstract description 13
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 239000000447 pesticide residue Substances 0.000 abstract description 4
- 238000013329 compounding Methods 0.000 abstract description 2
- 230000001094 effect on targets Effects 0.000 abstract description 2
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 40
- 239000003814 drug Substances 0.000 description 21
- 230000000694 effects Effects 0.000 description 16
- 241000238631 Hexapoda Species 0.000 description 12
- 241000344246 Tetranychus cinnabarinus Species 0.000 description 12
- 239000000839 emulsion Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 231100000419 toxicity Toxicity 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- -1 2, 4, 6-trimethylphenyl Chemical group 0.000 description 6
- 238000004166 bioassay Methods 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- 241001454294 Tetranychus Species 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000003094 microcapsule Substances 0.000 description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- 241000207199 Citrus Species 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000002390 adhesive tape Substances 0.000 description 3
- 235000020971 citrus fruits Nutrition 0.000 description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 241000255777 Lepidoptera Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000006229 carbon black Substances 0.000 description 2
- 230000002301 combined effect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920005646 polycarboxylate Polymers 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- MLMQPDHYNJCQAO-UHFFFAOYSA-M 3,3-dimethylbutanoate Chemical compound CC(C)(C)CC([O-])=O MLMQPDHYNJCQAO-UHFFFAOYSA-M 0.000 description 1
- 241000239223 Arachnida Species 0.000 description 1
- 241000526200 Cacopsylla pyri Species 0.000 description 1
- 241000725028 Kuwayama Species 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 241000721621 Myzus persicae Species 0.000 description 1
- 241000488581 Panonychus citri Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 241001454293 Tetranychus urticae Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 239000000642 acaricide Substances 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 239000013538 functional additive Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940095686 granule product Drugs 0.000 description 1
- 231100000171 higher toxicity Toxicity 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000010902 jet-milling Methods 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- PEQJBOMPGWYIRO-UHFFFAOYSA-N n-ethyl-3,4-dimethoxyaniline Chemical compound CCNC1=CC=C(OC)C(OC)=C1 PEQJBOMPGWYIRO-UHFFFAOYSA-N 0.000 description 1
- 239000004533 oil dispersion Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- 239000007944 soluble tablet Substances 0.000 description 1
- 125000003003 spiro group Chemical group 0.000 description 1
- 239000004551 spreading oil Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 239000004565 water dispersible tablet Substances 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticide disinfestation and acaricidal, and particularly discloses an insecticidal and acaricidal composition containing spiromesifen, wherein the active ingredients of the insecticidal and acaricidal composition comprise spiromesifen and a compound shown in a formula I:
Description
Technical Field
The invention belongs to the technical field of pesticide disinsection and acaricidal, and particularly discloses an insecticidal and acaricidal composition containing spiromesifen and application thereof.
Background
Spiromesifen, CAS accession number: 283594-90-1, the chemical name is [ 2-oxo subunit-3- (2, 4, 6-trimethylphenyl) -1-oxaspiro [4.4] non-3-en-4-yl ]3, 3-dimethylbutyrate, which is spiro tetronic acid insecticidal and acaricidal agent developed by Bayer company, has unique action mechanism, and can destroy energy metabolism activity of mites by inhibiting fat synthesis in mites, and finally kill the mites. The structural formula is as follows:
The compound shown in the formula I is a novel phenylpyrazole nicotinamide fluorine-containing pesticide, the chemical name of the novel phenylpyrazole nicotinamide fluorine-containing pesticide is N-methyl-N-cyclopropyl-2-chloro-5- [1- (2, 6-dichloro-4-heptafluoroisopropylphenyl) -pyrazol-4-yl ] nicotinamide, and the molecular formula of the novel phenylpyrazole nicotinamide fluorine-containing pesticide is C 22H14Cl3F7N4 O. The insecticidal composition has excellent insecticidal effect on lepidoptera pests and acarina pests, and also has a certain control effect on myzus persicae which are lepidoptera pests, and the structural formula is as follows:
Spider mites are important phytophagous mites in agricultural production, belong to the arachnids, the acarina, the total order of real mites, the front valve sub order and She Manzong families, and are extremely easy to explode and disaster, and greatly influence the yield and quality of vegetables because the spider mites have the characteristics of small individuals, short generations, rapid propagation, wide hosts and the like.
The psyllids can occur for several generations in one year, each generation of the psyllids overlap, and adult nymphs gather on the tender buds of host plants and mainly take the sap of the adult nymphs, leaf stalks, young shoots and fruits as a hazard. When the nymphs eat, sticky substances are secreted, mold breeding is caused on the leaves, light people influence photosynthesis of the leaves, and heavy people cause fallen leaves; the fruits are harmful to form irregular rust-colored plaques, the appearance quality of the fruits is seriously affected, and even the economic value is lost.
Disclosure of Invention
In order to solve the problems in the prior art, the inventor carries out deep analysis on spiromesifen and then compounds the spiromesifen with different insecticidal and acaricidal compounds, and surprisingly discovers that: the spiromesifen and the compound shown in the formula I are compounded according to a certain weight ratio, so that a synergistic effect can be generated, the insecticidal and acaricidal activity is enhanced, the pesticide usage amount is reduced, the control cost is reduced, and the pesticide residue of agricultural products is reduced. Based on the above findings, the present invention has been completed.
In order to achieve the above purpose, the present invention is realized by the following technical scheme: an insecticidal and acaricidal composition containing spiromesifen, wherein the active ingredients of the insecticidal and acaricidal composition comprise spiromesifen and a compound of formula I:
further, the mass ratio of the compound of the formula I to the spiromesifen is 1:20-40:1.
Further, the mass ratio of the compound of the formula I to spiromesifen is 1:20, 1:10, 1:5, 1:3, 1:1, 3:1, 5:1, 10:1, 20:1, 30:1, 40:1;
further, the mass ratio of the compound of the formula I to the spiromesifen is 1:10-40:1;
further, the mass ratio of the compound of the formula I to spiromesifen is 1:10, 1:5, 1:3, 1:1, 3:1, 5:1, 10:1, 20:1, 30:1, 40:1;
Further, the mass ratio of the compound of the formula I to the spiromesifen is 1:5-30:1;
Further, the mass ratio of the compound of the formula I to spiromesifen is 1:5, 1:3, 1:1, 3:1, 5:1, 10:1, 20:1, 30:1;
Further, the total weight of the insecticidal and acaricidal composition is calculated by 100 weight percent, and the total weight of the active ingredients spiromesifen and the compound in the formula I accounts for 2-80 percent of the total weight of the insecticidal and acaricidal composition;
Further, the total weight of the active component spiromesifen and the compound in the formula I accounts for 2-70% of the total weight of the insecticidal and acaricidal composition;
Further, the insecticidal and acaricidal composition comprises an agriculturally acceptable auxiliary ingredient besides an active ingredient, wherein the auxiliary ingredient is selected from one or more of a wetting agent, a dispersing agent, an emulsifying agent, a thickening agent, a disintegrating agent, an antifreezing agent, an antifoaming agent, a solvent, a preservative, a stabilizing agent, a synergist or a carrier;
Further, the insecticidal and acaricidal composition can be prepared into any one of agriculturally acceptable preparation forms, and the preparation forms are solid preparations and/or liquid preparations;
Further, the solid preparation is selected from a direct-use solid preparation, a dispersible solid preparation and/or a soluble solid preparation;
Further, the directly-used solid preparation is powder, granule, sphere, tablet or strip;
the dispersible solid preparation is wettable powder, oil dispersion powder, emulsion powder, water dispersible granule, emulsion granule or water dispersible tablet;
the soluble solid preparation is soluble powder, soluble tablets or soluble granules;
Further, the liquid preparation is a solution preparation, a dispersion liquid preparation, an emulsion preparation, a suspension preparation or a multiphase preparation;
Further, the solution preparation is a soluble agent, an oil agent or a film spreading oil agent;
the dispersion liquid preparation is emulsifiable concentrate, emulsion, dispersible agent or paste;
the emulsion preparation is aqueous emulsion, oil emulsion, microemulsion or fat agent;
The suspension preparation is suspending agent, microcapsule suspending agent, oil suspending agent or dispersible oil suspending agent;
the multiphase preparation is a suspension emulsion, a microcapsule suspension-suspending agent, a microcapsule suspension-water emulsion or a microcapsule suspension-suspending emulsion;
further, the liquid preparation is selected from suspending agents, and the solid preparation is selected from water dispersible granules or wettable powder;
the invention also discloses the application of the insecticidal and acaricidal composition in controlling plant pest mites;
further, the crop pests are psyllidae pests, and the plant pest mites are spider mites;
Further, the psyllidae pests are pear psyllids, citrus psyllids or mulberry psyllids, and the spider mites are tetranychus cinnabarinus, tetranychus urticae, tetranychus truncatum and/or panonychus citri;
Further, the psyllidae pests are diaphorina citri, and the spider mites are spider mites;
Further, the insecticidal and acaricidal composition and/or the preparation thereof are applied to mites or a growth medium thereof.
The invention has the beneficial effects that:
1) The insecticidal and acaricidal composition improves the synergistic effect of the insecticidal and acaricidal agent and the control effect on target pests and mites through the interaction of the effective components;
2) The insecticidal and acaricidal composition provided by the invention simultaneously reduces the prevention and control cost, reduces the pollution to the environment, effectively reduces the pesticide residue and reduces the harm to beneficial organisms;
3) The insecticidal and acaricidal composition of the invention is superior to single agent in quick-acting property and lasting effect, and is beneficial to the comprehensive control of agricultural pests and mites.
Detailed Description
The present invention will be described in more detail with reference to the following examples, but the present invention can be embodied in various forms and should not be construed as being limited to the embodiments set forth herein.
Preparation examples (the following percentages are weight percent)
Preparation example 1:24% of the compound of formula I spiromesifen suspending agent (5:1)
The formula comprises the following components: 20% of a compound shown in the formula I, 4% of spiromesifen, 2% of fatty alcohol polyoxyethylene ether, 3% of alkylphenol polyoxyethylene ether phosphate, 1% of polycarboxylate, 0.2% of xanthan gum, 1% of magnesium aluminum silicate, 5% of ethylene glycol, 0.01% of benzisothiazolinone, 0.5% of silicone oil and the balance of deionized water.
The preparation method comprises the following steps: according to the formula proportion, the active ingredients, the surfactant and other functional auxiliary agents are sequentially placed in a reaction kettle, water is added and mixed uniformly, high-speed shearing and wet sanding are carried out, and finally, the suspending agent product is obtained through homogenizing and filtering.
Preparation example 2:22% of a compound of formula I spiromesifen suspension (10:1)
The formula comprises the following components: 20% of a compound shown in the formula I, 2% of spiromesifen, 2% of isomeric trideceth polyoxyethylene ether, 3% of alkylphenol polyoxyethylene ether phosphate, 1% of succinate sulfonate, 2% of block polyether, 0.2% of xanthan gum, 1% of magnesium aluminum silicate, 4% of propylene glycol, 0.2% of sodium benzoate, 0.5% of silicone oil and the balance of deionized water.
The preparation method comprises the following steps: the same as in preparation example 1.
Preparation example 3:30% of formula I compound spiromesifen water dispersible granule (1:1)
The formula comprises the following components: 15% of a compound of the formula I, 15% of spiromesifen, 10% of sodium lignin sulfonate, 2% of polycarboxylate sodium salt, 2% of nekal BX, 5% of anhydrous sodium sulfate and the balance of kaolin.
The preparation method comprises the following steps: adding active ingredients into a carrier according to the formula proportion, adding a surfactant and other functional additives into the carrier, mixing, adding 10-25% of water after jet milling, and then kneading, granulating, drying and screening to obtain a water dispersible granule product; or spraying water, granulating, drying, and sieving to obtain the final product.
Preparation example 4:36% of formula I compound spiromesifen water dispersible granule (3:1)
The formula comprises the following components: 27% of a compound shown in the formula I, 9% of spiromesifen, 2% of sodium dodecyl benzene sulfonate, 8% of naphthalene sulfonate formaldehyde condensate, 2% of fenpropargyl, 5% of urea and the balance of kaolin.
The preparation method comprises the following steps: the same as in preparation example 3.
Preparation example 5:40% of compound of formula I, spiromesifen wettable powder (1:3)
The formula comprises the following components: 10% of a compound shown in the formula I, 30% of spiromesifen, 4% of sodium lignin sulfonate, 3% of sodium dodecyl benzene sulfonate, 1% of fenpropargyl, 6% of white carbon black and the balance of kaolin;
the preparation method comprises the following steps: the effective components, the dispersing agent, the wetting agent and the filler are mixed according to the formula proportion, evenly stirred in a stirring kettle, and crushed and mixed evenly for many times by an airflow crusher, thus obtaining the wettable powder of the composition.
Preparation example 6:27% Compound of formula I spiromesifen wettable powder (1:1)
The formula comprises the following components: 13.5% of the compound of the formula I, 13.5% of spiromesifen, 5% of calcium lignosulfonate, 4% of sodium dodecyl benzene sulfonate, 5% of white carbon black and the balance of kaolin.
The preparation method comprises the following steps: the same as in preparation example 5.
Indoor Activity test
Example 1: indoor bioassay test of tetranychus cinnabarinus compounded by spiromesifen and compound of formula I
The test is based on: test reference NY/T1154.12-2008 "pesticide in laboratory bioassay test guidelines section 12: tetranychus slide dipping method, NY/T1154.7-2006 pesticide section 7, guidelines for pesticide indoor bioassay test: determination of the combined action of compounding.
Test target: tetranychus cinnabarinus (Tetranychus cinnabarinnum Boisduval).
Test agent: 98% of spiromesifen raw medicine and 92% of compound raw medicine of formula I are provided by the research and development center of the sea li pharmaceutical industry group.
Preparing a test material: cutting double faced adhesive tape into 2cm long, attaching to one end of a glass slide, selecting healthy adult mites, attaching the back of each piece of double faced adhesive tape (without sticking mite feet, tentacles and mouth parts), placing 30 pieces of double faced adhesive tape into a container filled with wet sponge, covering a cover, and placing under the condition of (25+/-1) DEG C. And 2h later, microscopic examination is carried out, dead and injured individuals are removed, and 30 pieces of the patients are complemented.
And (3) preparation of a medicament: dissolving the above raw materials with proper solvent, and preparing proper mass concentration gradient according to the pharmaceutical activity by an equal ratio method.
And (3) medicament treatment: immersing the slide in the liquid medicine, slightly shaking for 5s, taking out, sucking the excessive liquid medicine by using water absorbing paper, placing in a white porcelain tray filled with wet sponge, and covering with a plastic film with good light transmittance. Each treatment was repeated 4 times and a treatment without the agent (with all organic solvents and emulsifiers) was set as a blank.
Feeding and observing: and (3) feeding and observing the container with the insect test at the temperature of (25+/-1) ℃ and the photoperiod of L:D= (16:8) h.
Checking: and (5) checking death conditions of the test insects 48h after treatment, and recording total insects and death insects respectively.
Data statistics and analysis:
the calculation method comprises the following steps: the corrected mortality of each treatment was calculated from the survey data, calculated according to formulas (1) and (2).
Wherein:
P-mortality in percent (%);
k is the number of dead insects, and the unit is the head;
n is the number of insects in treatment, and the unit is the head;
wherein:
P 1 -corrected mortality in percent (%);
P t -mortality in percent (%);
P 0 -control mortality in percent (%).
If the control mortality is less than 5%, correction is not needed; the control mortality is between 5% and 20%, and correction is carried out according to the formula (2); control mortality was > 20% and the test was reworked.
The test adopts a DPS statistical analysis system to analyze, obtains LC 50 value and evaluates the activity of the test agent on the biological test material.
The co-toxicity coefficient (CTC value) of the mixture is calculated according to the formulas (3), (4) and (5):
wherein:
ati—actual measured virulence index of the mixture;
S-LC 50 of standard agricultural chemicals in milligrams per liter (mg/L);
M-LC 50 of the mix in milligrams per liter (mg/L).
TTI＝TIA×PA+TIB×PB·······(4)
Wherein:
TTI-the theoretical toxicity index of the mixture;
TI A A agent toxicity index;
The percentage content of the P A -A medicament in the mixture is expressed as percentage (%);
TI B -agent toxicity index;
The percentage of the P B -B medicament in the mixture is expressed as percentage (%).
Wherein:
ctc—co-toxicity coefficient;
ati—actual measured virulence index of the mixture;
TTI-the theoretical toxicity index of the mixture.
The compound co-toxicity coefficient CTC is more than or equal to 120 and shows synergistic effect; ctc.ltoreq.80 shows antagonism; 80 < CTC < 120 shows additive effect. Indoor combined action test the following table:
TABLE 1 results of indoor bioassay experiments of spiromesifen and Tetranychus cinnabarinus compounded with Compound of formula I
As can be seen from the indoor test results of the table, the insecticidal and acaricidal composition has good control effect on tetranychus cinnabarinus, and the compound shown in the formula I has higher toxicity on tetranychus cinnabarinus, and the LC 50 of the composition is 2.7002mg/L. The mass ratio of the compound of the formula I to the spiromesifen is 1:20-40:1, the co-toxicity coefficient (CTC) is more than 120, and the combined effect is synergistic; the mass ratio of the compound of the formula I to the spiromesifen is 1:10-40:1, the co-toxicity coefficient is more than 130, and the synergy is obvious; the mass ratio of the compound of the formula I to the spiromesifen is 1:5-30:1, the co-toxicity coefficient is more than 140, and the synergy is remarkable.
Example 2: indoor bioassay test of spiromesifen and compound of formula I on diaphorina citri
The test method comprises the following steps: the leaf dipping method is adopted.
Test target: diaphorina citri (Diaphorina citri Kuwayama).
Test agent: 98% of spiromesifen raw medicine and 92% of compound raw medicine of formula I are provided by the research and development center of the sea li pharmaceutical industry group.
And (3) preparation of a medicament: the mother solution of each single agent is prepared respectively, and the proper proportion is designed according to the mixing purpose and the medicament activity, and each single agent and each group of proportion are mixed to prepare the required series of mass concentration.
The test steps are as follows:
(1) Preparing a test material: selecting mature citrus leaves which are not sprayed with any medicament in the current year and have good growth and complete shape, cleaning and airing.
(2) And (3) medicament treatment: immersing citrus leaves in each treated liquid medicine for 10s, setting Tween 80 water solution containing no medicament but corresponding solvent as blank control, airing, placing in culture dishes with diameter of 9cm for standby (1 leaf per dish), wrapping the base of the stems of the citrus leaves with absorbent cotton containing water for moisturizing, placing filter paper containing proper amount of water at the bottom of the culture dishes, and keeping the humidity in the culture dishes proper.
(3) And (3) insect inoculation: and (3) inoculating the test insects onto the treated leaves by using a writing brush, covering a culture dish by using a gauze for 20 heads of test insects on each leaf, covering a dish cover (a small hole is reserved on the dish cover), repeating each treatment for 4 times, and culturing in a climatic chamber with the temperature of 25+/-1 ℃ and the relative humidity of 65+/-5% and the photoperiod of L:D=14:10.
(4) Investigation:
the number of viable insects per treatment was checked and recorded 48h after treatment. From the survey data, corrected mortality for each treatment was calculated.
(6) Data statistics and analysis:
The corrected mortality is calculated according to formulas (1) and (2):
wherein:
p-mortality in percent (%);
k-represents the number of dead insects in units of heads;
n-represents the total number of insects treated in units of heads.
Wherein:
p 1 -correct mortality in percent (%);
p t -mortality in percent (%);
P 0 -control mortality in percent (%).
If the control mortality is less than 5%, correction is not needed; the control mortality is between 5% and 20%, and correction is carried out according to the formula (2); control mortality was > 20% and the test was reworked.
And processing the data by adopting a probability value analysis method. The LC 50 value is obtained by DPS statistical analysis system analysis, and the activity of the test agent on the biological test material is evaluated.
The co-toxicity coefficient (CTC value) of the mixture is calculated according to the formulas (3), (4) and (5):
wherein:
ati—actual measured virulence index of the mixture;
S-LC 50 of standard agricultural chemicals in milligrams per liter (mg/L);
M-LC 50 of the mix in milligrams per liter (mg/L).
TTI＝TIA*PA+TIB*PB.······(4)
Wherein:
TTI-the theoretical toxicity index of the mixture;
TI A A agent toxicity index;
The percentage content of the P A -A medicament in the mixture is expressed as percentage (%);
TI B -agent toxicity index;
The percentage of the P B -B medicament in the mixture is expressed as percentage (%).
Wherein:
ctc—co-toxicity coefficient;
ati—actual measured virulence index of the mixture;
TTI-the theoretical toxicity index of the mixture.
The compound co-toxicity coefficient CTC is more than or equal to 120 and shows synergistic effect; ctc.ltoreq.80 shows antagonism; 80 < CTC < 120 shows additive effect.
The results of the indoor test are shown in the following table:
TABLE 2 results of indoor bioassay experiments of spiromesifen and Compound of formula I on diaphorina citri
| Medicament treatment | LC50(mg/L) | ATI | TTI | Co-toxicity coefficient (CTC) |
| Compounds of formula I | 8.3305 | 17.359 | - | / |
| Spiromesifen | 1.4461 | 100.000 | - | / |
| Compounds of formula I spiromesifen=1:20 | 1.1475 | 958.606 | 96.065 | 131.184 |
| Compounds of formula I spiromesifen=1:10 | 1.0791 | 1019.368 | 92.487 | 144.896 |
| Compounds of formula I spiromesifen=1:5 | 0.9671 | 1137.421 | 86.227 | 173.415 |
| Compounds of formula I spiromesifen=1:1 | 1.3707 | 802.510 | 58.680 | 179.791 |
| Compounds of formula I spiromesifen=10:1 | 3.4902 | 315.168 | 24.872 | 166.586 |
| Compounds of formula I spiromesifen=30:1 | 4.9348 | 222.907 | 20.025 | 146.338 |
| Compounds of formula I spiromesifen=40:1 | 5.9515 | 184.827 | 19.375 | 125.411 |
As can be seen from the indoor test results in the table, the insecticidal and acaricidal composition provided by the invention also has a good control effect on diaphorina citri, the mass ratio of the compound shown in the formula I to spiromesifen is 1:20-40:1, the co-toxicity coefficient (CTC) is greater than 120, and the combined effect is shown as synergy.
Field efficacy test
Example 3: field efficacy test of spiromesifen and compound of formula I on Tetranychus cinnabarinus
The test is based on: the test is carried out by referring to GB/T17980.17-2000 "pesticide field efficacy test criterion (one) acaricide for controlling beans and vegetable spider mites".
Test target: tetranychus cinnabarinus (Tetranychus cinnabarinnum Boisduval).
Test crops and varieties: potato (netherlands No. 15).
Test site: the soil of the test field is yellow cotton soil, the fertility is moderate, the topography is flat, and the previous crop is corn.
The test method comprises the following steps: the test cell area was 20m 2, and each treatment was repeated 4 times. The experiment is applied on the 7 th and 10 th 2019, and the pesticide is sprayed by a industrial pesticide-16 type knapsack sprayer, so that the whole plant is uniformly sprayed during pesticide spraying, and the leaves are uniformly coated. The amount of drug applied was 750L/hm 2.
Experimental investigation: the number of the vermilion mites was examined before the test application, and the vermilion mites were examined once each of 3d, 7d and 14d after the application, and the total of the examination was 4 times. During investigation, 20 leaves with spider mites are fixedly selected in each district, the number of live mites is investigated, and the control effect is calculated.
The drug effect calculation method comprises the following steps:
the results of the field efficacy test are shown in the following table:
table 3 results of field efficacy test of spiromesifen and Compound of formula I against tetranychus cinnabarinus
The field efficacy test results show that the insecticidal and acaricidal composition has good control effect on tetranychus cinnabarinus. 3d after the medicine, the treatment prevention effect of each preparation example is higher than 70%, and the quick-acting property is good. After 14d, the control effect of 24% of the compound of formula I, spiromesifen suspending agent (5:1) treatment group reaches 91.80%, the duration of the effect is longer, and the effect is good.
Indoor tests and field pesticide effect results show that the insecticidal and acaricidal composition has good control effect on common pests such as diaphorina citri, tetranychus cinnabarinus and the like or tetranychus cinnabarinus. The preparation has good quick-acting property, long lasting period, safety and high efficiency, enhances the insecticidal and acaricidal activity, reduces the using amount of pesticides, reduces the prevention and control cost and reduces the pesticide residue of agricultural products.
Claims (12)
1. The insecticidal and acaricidal composition containing spiromesifen is characterized in that the active ingredients of the insecticidal and acaricidal composition comprise spiromesifen and a compound of formula I: the mass ratio of the compound of the formula I to the spiromesifen is 1:20-40:1.
2. The insecticidal and acaricidal composition according to claim 1, wherein the mass ratio of the compound of formula i to spiromesifen is 1:10-40:1.
3. The insecticidal and acaricidal composition according to claim 1, wherein the mass ratio of the compound of formula i to spiromesifen is 1:5-30:1.
4. The insecticidal and acaricidal composition according to claim 1, wherein the total weight of the insecticidal and acaricidal composition is 100wt%, and the total weight of the active ingredient spiromesifen and the compound of formula i is 2-80% of the total weight of the insecticidal and acaricidal composition.
5. The insecticidal and acaricidal composition according to claim 4, wherein the total weight of the insecticidal and acaricidal composition is 100wt%, and the total weight of the active ingredient spiromesifen and the compound of formula i is 2-70% of the total weight of the insecticidal and acaricidal composition.
6. The insecticidal and acaricidal composition according to claim 1, wherein the insecticidal and acaricidal composition comprises an agriculturally acceptable auxiliary ingredient in addition to the active ingredient, said auxiliary ingredient being selected from one or more of a wetting agent, a dispersing agent, an emulsifying agent, a thickening agent, a disintegrating agent, an antifreezing agent, an antifoaming agent, a solvent, a preservative, a stabilizing agent, a synergist or a carrier.
7. The insecticidal and acaricidal composition according to claim 1, wherein said insecticidal and acaricidal composition can be prepared into agriculturally acceptable dosage forms, said dosage forms being solid or liquid; the liquid preparation is selected from suspending agents, and the solid preparation is selected from water dispersible granules or wettable powder.
8. Use of the insecticidal and acaricidal composition according to any one of claims 1 to 7 for controlling plant pests and/or mites.
9. The use according to claim 8, wherein the plant pest is a psyllidae pest; the plant pest mites are Tetranychidae pest mites.
10. The use according to claim 9, wherein the psyllidae is psyllid, diaphorina citri or psyllid, and the spider mites are spider mites, spider mites and/or spider mites.
11. The use according to claim 10, wherein the psyllidae is diaphorina citri and the spider mite is spider mite.
12. Use according to claim 8, characterized in that the insecticidal and acaricidal composition and/or the preparation thereof is applied to pests and/or mites or their growth media.
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