CN115814038B - Cow nipple disinfectant and preparation method thereof - Google Patents
Cow nipple disinfectant and preparation method thereof Download PDFInfo
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- CN115814038B CN115814038B CN202111656801.XA CN202111656801A CN115814038B CN 115814038 B CN115814038 B CN 115814038B CN 202111656801 A CN202111656801 A CN 202111656801A CN 115814038 B CN115814038 B CN 115814038B
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- iodine
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 67
- 210000002445 nipple Anatomy 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title abstract description 19
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims abstract description 33
- 239000000419 plant extract Substances 0.000 claims abstract description 29
- 229920000642 polymer Polymers 0.000 claims abstract description 28
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000003974 emollient agent Substances 0.000 claims abstract description 27
- 239000011630 iodine Substances 0.000 claims abstract description 27
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 27
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000011575 calcium Substances 0.000 claims abstract description 26
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 26
- 150000001875 compounds Chemical class 0.000 claims abstract description 26
- -1 hydroxyl compound Chemical class 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000002562 thickening agent Substances 0.000 claims abstract description 25
- 239000012153 distilled water Substances 0.000 claims abstract description 24
- 238000003756 stirring Methods 0.000 claims abstract description 16
- 239000000243 solution Substances 0.000 claims abstract description 15
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims abstract description 11
- DKNPRRRKHAEUMW-UHFFFAOYSA-N Iodine aqueous Chemical compound [K+].I[I-]I DKNPRRRKHAEUMW-UHFFFAOYSA-N 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 9
- 238000001816 cooling Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 238000010992 reflux Methods 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 39
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 25
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 25
- 229960005069 calcium Drugs 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 22
- 229940119485 safflower extract Drugs 0.000 claims description 20
- 229940037003 alum Drugs 0.000 claims description 18
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 18
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 18
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 18
- 229940067866 dandelion extract Drugs 0.000 claims description 16
- 235000020691 dandelion extract Nutrition 0.000 claims description 16
- 239000001845 taraxacum officinale leaf extract Substances 0.000 claims description 16
- 239000008513 turmeric extract Substances 0.000 claims description 15
- 229940052016 turmeric extract Drugs 0.000 claims description 15
- 235000020240 turmeric extract Nutrition 0.000 claims description 15
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 14
- 239000002202 Polyethylene glycol Substances 0.000 claims description 14
- 239000001110 calcium chloride Substances 0.000 claims description 14
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 14
- 239000004227 calcium gluconate Substances 0.000 claims description 14
- 235000013927 calcium gluconate Nutrition 0.000 claims description 14
- 229960004494 calcium gluconate Drugs 0.000 claims description 14
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 14
- 239000011259 mixed solution Substances 0.000 claims description 14
- 239000004006 olive oil Substances 0.000 claims description 14
- 235000008390 olive oil Nutrition 0.000 claims description 14
- 229920001223 polyethylene glycol Polymers 0.000 claims description 14
- YZYASTRURKBPPS-UHFFFAOYSA-N C(CCC(=O)OCCCCCC(C)C)(=O)OCCCCCC(C)C.[Na] Chemical compound C(CCC(=O)OCCCCCC(C)C)(=O)OCCCCCC(C)C.[Na] YZYASTRURKBPPS-UHFFFAOYSA-N 0.000 claims description 12
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 12
- 238000006136 alcoholysis reaction Methods 0.000 claims description 9
- 239000000230 xanthan gum Substances 0.000 claims description 8
- 235000010493 xanthan gum Nutrition 0.000 claims description 8
- 229920001285 xanthan gum Polymers 0.000 claims description 8
- 229940082509 xanthan gum Drugs 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 4
- 241000283690 Bos taurus Species 0.000 abstract description 61
- 230000001954 sterilising effect Effects 0.000 abstract description 13
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 12
- 230000007794 irritation Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 6
- 210000005036 nerve Anatomy 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 23
- 235000011148 calcium chloride Nutrition 0.000 description 13
- 235000013365 dairy product Nutrition 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 10
- 239000008267 milk Substances 0.000 description 7
- 210000004080 milk Anatomy 0.000 description 7
- 239000000284 extract Substances 0.000 description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 244000020518 Carthamus tinctorius Species 0.000 description 3
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- 244000163122 Curcuma domestica Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- 229920000153 Povidone-iodine Polymers 0.000 description 2
- 229960004543 anhydrous citric acid Drugs 0.000 description 2
- 235000006533 astragalus Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 150000002496 iodine Chemical class 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 229960001621 povidone-iodine Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 2
- 229960002218 sodium chlorite Drugs 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 241000045403 Astragalus propinquus Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 240000000691 Houttuynia cordata Species 0.000 description 1
- 235000013719 Houttuynia cordata Nutrition 0.000 description 1
- 239000009141 Houttuynia cordata plant extract Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 241000245665 Taraxacum Species 0.000 description 1
- 241000292546 Taraxacum mongolicum Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- MQKXWEJVDDRQKK-UHFFFAOYSA-N bis(6-methylheptyl) butanedioate Chemical compound CC(C)CCCCCOC(=O)CCC(=O)OCCCCCC(C)C MQKXWEJVDDRQKK-UHFFFAOYSA-N 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 239000004281 calcium formate Substances 0.000 description 1
- 229940044172 calcium formate Drugs 0.000 description 1
- 235000019255 calcium formate Nutrition 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- JMGZBMRVDHKMKB-UHFFFAOYSA-L disodium;2-sulfobutanedioate Chemical compound [Na+].[Na+].OS(=O)(=O)C(C([O-])=O)CC([O-])=O JMGZBMRVDHKMKB-UHFFFAOYSA-L 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 150000002440 hydroxy compounds Chemical class 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- KRVIMMAOCNANRA-UHFFFAOYSA-N iodine;pyrrolidin-2-one Chemical compound [I].O=C1CCCN1 KRVIMMAOCNANRA-UHFFFAOYSA-N 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a cow nipple disinfectant, which is prepared from the following raw materials: iodine, potassium iodide, hydroxyl compound, high molecular polymer, thickener, emollient, calcium-containing compound, alumen, plant extract, and distilled water, and its preparation method comprises the following steps: dissolving iodine and potassium iodide in part of distilled water to obtain iodine solution; adding high molecular polymer into distilled water, heating, condensing, refluxing, stirring and dissolving; cooling to room temperature, adding thickener and hydroxyl compound, and dissolving completely; and finally adding iodine solution, emollient, calcium-containing compound, alumen and plant extract, and stirring thoroughly for dissolving. The self-heating medicinal mud is obtained. The prepared cow nipple disinfectant has the advantages of high film forming rate, good effect, capability of reducing skin and nerve irritation of the disinfectant to cows, effective prevention of cow nipple chapping, good sterilization effect, strong stability and capability of improving self-defense mechanism of cows.
Description
Technical Field
The invention relates to the application field of disinfectants, in particular to a cow nipple disinfectant and a preparation method thereof, and the application field of the disinfectant is A61K 33/18.
Background
The quality of the dairy products is directly related to the health of the dairy cows, which are especially the teats. The dairy cows need to be disinfected before and after milking every day, if the disinfection is incomplete, the incidence rate of the dairy cow mastitis can be increased, and if the irritation of the disinfectant is too strong, certain irritation can be generated on the mammary gland skin and internal tissues of the dairy cows, and then certain damage is caused on the breast related tissues of the dairy cows, so that the milk yield of the dairy cows is affected.
The currently applied cow nipple disinfectant is mainly iodine disinfectant and mainly comprises polyvinylpyrrolidone (PVP), iodine, potassium iodide, glycerol, ethanol and a thickener. Patent CN201910819255.3 discloses a cleaning disinfectant for cow nipple medicated bath and a use method thereof, the cleaning disinfectant consists of sodium chlorite, anhydrous citric acid, anhydrous sodium citrate, high molecular polymer, anhydrous magnesium sulfate, guar gum and sodium dodecyl sulfate, an acidic buffer system formed by the anhydrous sodium citrate and the anhydrous citric acid promotes sodium chlorite and hydrogen ions to react, and generates chlorine dioxide to play a role in killing viruses and bacteria, and the disinfectant has good stability after film formation and can also prevent skin chapping to a certain extent. Patent CN201210183433.6 discloses a cow nipple disinfectant with film-forming nursing function and its preparation method, the disinfectant is composed of iodine, potassium iodide, chlorhexidine, high molecular polymer, surfactant, emollient, hydroxy compound and water, and the sterilizing effect is enhanced by compounding iodine and chlorhexidine, and the disinfectant has good stability, safety and no irritation. However, the disinfectant only depends on the formed film to realize sterilization, and cannot improve the self-defense function of the dairy cows.
The plant extract has rich active ingredients and no irritation, and can be used for research and preparation of disinfectant for cow nipple. Patent CN201610532939.1 discloses a cow nipple disinfectant, which is prepared from houttuynia cordata extract, safflower extract, alum and activated iodine powder, wherein the houttuynia cordata is used for realizing bacteriostasis, the activated iodine powder is used for realizing sterilization, the safflower is used for promoting blood circulation to remove blood stasis and promoting milk duct healing, the alum plays a role in collecting milk, the opening time of the milk duct after milking is obviously shortened, and the self defense system of the cow is improved. However, the disinfectant can not form an effective protective film on the nipple surface of the dairy cows, and plays a role in long-term disinfection and protection.
Disclosure of Invention
In order to solve the problems, the first aspect of the invention provides a cow nipple disinfectant, which comprises the following preparation raw materials in parts by weight: 1-3 parts of iodine, 6-10 parts of potassium iodide, 5-10 parts of hydroxyl compound, 2-6 parts of high molecular polymer, 1-3 parts of thickener, 1-3 parts of emollient, 0.1-0.5 part of calcium-containing compound, 1-3 parts of alum, 8-15 parts of plant extract and 60-80 parts of distilled water.
As a preferred embodiment, the hydroxyl compound is selected from one or more of glycerol, propylene glycol, polyethylene glycol 400;
As a preferred embodiment, the high molecular polymer is selected from one or more of polyvinylpyrrolidone, polyvinyl alcohol, hydroxypropyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, and alginic acid; further preferably, the high molecular polymer is a mixture of polyvinylpyrrolidone and polyvinyl alcohol;
As a preferred embodiment, the mass ratio of polyvinylpyrrolidone to polyvinyl alcohol is in the range of (8-10): 1, a step of;
As a preferred embodiment, the polyvinyl alcohol has a viscosity average molecular weight of 10000-18000, a viscosity of 2.0-5.0mpa.s and an alcoholysis degree of 77-95%; further preferably, the polyvinyl alcohol has a viscosity average molecular weight of 12000-16800, a viscosity of 3.0-4.5mpa.s, and an alcoholysis degree of 86-90%;
As a preferred embodiment, the thickener is selected from the group consisting of a mixture of one or more of gelatin, guar gum and xanthan gum; further preferably, the thickener is xanthan gum;
as a preferred embodiment, the emollient is selected from one or more of lanolin polyoxyethylene ether, polyethylene glycol olive oil ester, vitamin E, acetate, and sodium diisooctyl succinate; further preferably, the emollient is polyethylene glycol olive oil ester and sodium diisooctyl succinate;
As a preferred embodiment, the mass ratio of the polyethylene glycol olive oil ester to the diisooctyl succinate sodium sulfonate is 1: (0.5-2);
As a preferred embodiment, the calcium-containing compound is selected from one or more of calcium carbonate, calcium chloride, calcium phosphate, calcium hydrogen phosphate, calcium gluconate, calcium formate, calcium lactate, and calcium acetate; further preferably, the calcium-containing compound is calcium chloride and calcium gluconate;
as a preferred embodiment, the mass ratio of the calcium chloride to the calcium gluconate is (0.5-1.5): 1, a step of;
As a preferred embodiment, the plant extract is selected from the group consisting of a mixture of one or more of safflower (Carthamus Tinctorius) extract, turmeric (Curcuma longa l.) extract, astragalus (Astragalus membranaceus (fischer) bge.) extract, dandelion (Taraxacum Mongolicum hand) extract and scutellaria (Scutellaria baicalensis Georgi (Lamiaceae)) extract; further preferably, the plant extract is a mixture of safflower extract, turmeric extract and dandelion extract;
as a preferred embodiment, the mass ratio of the safflower extract, the turmeric extract and the dandelion extract is 1: (2-5): (1-3); further preferably, the mass ratio of the safflower extract, the turmeric extract and the dandelion extract is 1:3:2.
The second aspect of the invention provides a method for preparing a cow nipple disinfectant, comprising the following steps:
(1) Weighing iodine and potassium iodide, and dissolving in part of distilled water to obtain iodine solution;
(2) Adding high molecular polymer into the rest distilled water, heating to 70-95 ℃, condensing, refluxing, stirring and dissolving; cooling to room temperature, adding a thickener and a hydroxyl compound, and fully dissolving to obtain a mixed solution;
(3) Adding the iodine solution, the emollient, the calcium-containing compound, the alum and the plant extract obtained in the step (1) into the mixed solution obtained in the step (2), and fully stirring and dissolving to obtain the cow nipple disinfectant.
Compared with the prior art, the invention has the following beneficial effects:
(1) The disinfectant has the advantages that iodine and potassium iodide are used as main sterilizing substances, the sterilizing effect is good and safe, the film forming rate and the film forming effect of the disinfectant can be obviously improved after the specific selected high molecular polymer and the thickening agent are added, the addition of the hydroxyl compound and the emollient can enable the disinfectant to be more compatible with the skin of the dairy cows, the skin and nerve irritation of the disinfectant to the dairy cows is reduced, the milk cow nipple is effectively prevented from being cracked, the added calcium-containing compound, alum and plant extract interact with iodine substances, the occurrence probability of the dairy cows on the aspects of improving the external sterilizing and bacteriostasis effects and the self defense mechanism of the dairy cows is reduced, the stability of the disinfectant is enhanced, and long-term effective use can be achieved.
(2) The inventor finds that the antibacterial and anti-inflammatory effects of the disinfectant can be obviously improved by adding the plant extract into the cow nipple disinfectant, and particularly, when the plant extract is a mixture of the safflower extract, the turmeric extract and the dandelion extract, the defending function of the cow can be improved at the same time. The reason is presumed that the safflower extract has the effects of promoting blood circulation, dredging channels, removing blood stasis and relieving pain, is beneficial to promoting the healing of milk ducts of cows and shortening the opening time of the milk ducts, and can further improve the antiviral immunity around the nipple of the cows by the synergistic effect of the safflower extract and the dandelion extract, thereby effectively reducing the incidence rate of the mammitis of the cows. Surprisingly, when the mass ratio of the safflower extract, the turmeric extract and the dandelion extract is 1:3:2, the obtained cow nipple disinfectant has optimal sterilization, antibiosis and self-defense function, and can inhibit the oxidation reaction of iodine and other components in the disinfectant, thereby further improving the stability of the cow nipple disinfectant.
(3) The polyvinyl pyrrolidone and iodine are combined to form amorphous povidone iodine, so that the polyvinyl pyrrolidone iodine has stable usability, no irritation and no irritation to mucous membranes and skin, but the film forming property of the povidone iodine is poor, and the inventor finds that the film forming property of a disinfectant can be improved by adding polyvinyl alcohol with viscosity average molecular weight of 10000-17000, viscosity of 3.0-4.5mpa.s and alcoholysis degree of 86-90%, and the polyvinyl alcohol has better water solubility, can be completely dissolved at normal temperature, but the formed film has poor flexibility and is easy to crack. After the xanthan gum is added, the viscosity of the disinfectant and the flexibility of the film can be further improved, the combination degree of the disinfectant and the cow nipple is improved, and the firmness and long-term protection of the disinfectant on the cow nipple are improved.
(4) The cow nipple disinfectant is prepared by blending iodine, potassium iodide, hydroxyl compound, high molecular polymer, thickener, emollient, calcium-containing compound, alum and plant extract. The selected components are safe and have no stimulation, the sterilization and bacteriostasis effects are obvious and durable, the preparation method is simple, the conditions are easy to realize, and the preparation method can be used for industrial production.
Detailed Description
Example 1:
1. The cow nipple disinfectant comprises the following preparation raw materials in parts by weight: 2 parts of iodine, 8 parts of potassium iodide, 7 parts of hydroxyl compound, 4 parts of high molecular polymer, 2 parts of thickener, 2 parts of emollient, 0.3 part of calcium-containing compound, 2 parts of alum, 11 parts of plant extract and 70 parts of distilled water.
The hydroxyl compound is a mixture of glycerol and polyethylene glycol 400;
the mass ratio of the glycerol to the polyethylene glycol 400 is 1:1, a step of;
The high molecular polymer is a mixture of polyvinylpyrrolidone and polyvinyl alcohol;
the mass ratio of the polyvinylpyrrolidone to the polyvinyl alcohol is 9:1, a step of;
The viscosity average molecular weight of the polyvinyl alcohol is 12000-16800, the viscosity is 3.0-4.5 Pa.s, the alcoholysis degree is 86-90% (purchased from Shanghai Shen Mu New Material Co., ltd., brand: PVA 088-03);
the thickener is xanthan gum (purchased from Siam Tianzheng pharmaceutic adjuvant Co., ltd.);
The emollient is polyethylene glycol olive oil ester (available from Wuhan Hua Xiangke Jie Biotechnology Co., ltd.) and diisooctyl sodium sulfosuccinate (CAS number: 577-11-7);
The mass ratio of the polyethylene glycol olive oil ester to the sodium diisooctyl succinate is 1:1.2;
The calcium-containing compound is calcium chloride and calcium gluconate;
the mass ratio of the calcium chloride to the calcium gluconate is 0.8:1, a step of;
the plant extract is a mixture of safflower extract, turmeric extract and dandelion extract;
the mass ratio of the safflower extract to the turmeric extract to the dandelion extract is 1:3:2;
2, a preparation method of a cow nipple disinfectant, comprising the following steps:
(1) Weighing iodine and potassium iodide, and dissolving in 30 parts of distilled water to obtain an iodine solution;
(2) Adding high molecular polymer into the rest 40 parts of distilled water, heating to 85 ℃, condensing, refluxing, stirring and dissolving; cooling to room temperature, adding a thickener and a hydroxyl compound, and fully dissolving to obtain a mixed solution;
(3) Adding the iodine solution, the emollient, the calcium-containing compound, the alum and the plant extract obtained in the step (1) into the mixed solution obtained in the step (2), and fully stirring and dissolving to obtain the cow nipple disinfectant.
Example 2:
1. The cow nipple disinfectant comprises the following preparation raw materials in parts by weight: 3 parts of iodine, 10 parts of potassium iodide, 10 parts of hydroxyl compound, 6 parts of high molecular polymer, 3 parts of thickener, 3 parts of emollient, 0.5 part of calcium-containing compound, 3 parts of alum, 15 parts of plant extract and 80 parts of distilled water.
The hydroxyl compound is a mixture of glycerol and polyethylene glycol 400;
the mass ratio of the glycerol to the polyethylene glycol 400 is 1:1, a step of;
The high molecular polymer is a mixture of polyvinylpyrrolidone and polyvinyl alcohol;
the mass ratio of the polyvinylpyrrolidone to the polyvinyl alcohol is 9:1, a step of;
The viscosity average molecular weight of the polyvinyl alcohol is 12000-16800, the viscosity is 3.0-4.5 Pa.s, and the alcoholysis degree is 86-90%;
The thickener is xanthan gum;
the emollient is polyethylene glycol olive oil ester and sodium diisooctyl succinate;
The mass ratio of the polyethylene glycol olive oil ester to the sodium diisooctyl succinate is 1:1.2;
The calcium-containing compound is calcium chloride and calcium gluconate;
the mass ratio of the calcium chloride to the calcium gluconate is 0.8:1, a step of;
the plant extract is a mixture of safflower extract, turmeric extract and dandelion extract;
the mass ratio of the safflower extract to the turmeric extract to the dandelion extract is 1:3:2;
2. a preparation method of a cow nipple disinfectant comprises the following steps:
(1) Weighing iodine and potassium iodide, and dissolving in 30 parts of distilled water to obtain an iodine solution;
(2) Adding high molecular polymer into the rest 40 parts of distilled water, heating to 85 ℃, condensing, refluxing, stirring and dissolving; cooling to room temperature, adding a thickener and a hydroxyl compound, and fully dissolving to obtain a mixed solution;
(3) Adding the iodine solution, the emollient, the calcium-containing compound, the alum and the plant extract obtained in the step (1) into the mixed solution obtained in the step (2), and fully stirring and dissolving to obtain the cow nipple disinfectant.
Comparative example 1:
1. The cow nipple disinfectant comprises the following preparation raw materials in parts by weight: 2 parts of iodine, 8 parts of potassium iodide, 7 parts of hydroxyl compound, 4 parts of high molecular polymer, 2 parts of thickener, 2 parts of emollient, 0.3 part of calcium-containing compound, 2 parts of alum, 11 parts of plant extract and 70 parts of distilled water.
The hydroxyl compound is a mixture of glycerol and polyethylene glycol 400;
the mass ratio of the glycerol to the polyethylene glycol 400 is 1:1, a step of;
The high molecular polymer is a mixture of polyvinylpyrrolidone and polyvinyl alcohol;
the mass ratio of the polyvinylpyrrolidone to the polyvinyl alcohol is 9:1, a step of;
The viscosity average molecular weight of the polyvinyl alcohol is 12000-16800, the viscosity is 3.0-4.5 Pa.s, and the alcoholysis degree is 86-90%;
The thickener is xanthan gum;
the emollient is polyethylene glycol olive oil ester and sodium diisooctyl succinate;
The mass ratio of the polyethylene glycol olive oil ester to the sodium diisooctyl succinate is 1:1.2;
The calcium-containing compound is calcium chloride and calcium gluconate;
the mass ratio of the calcium chloride to the calcium gluconate is 0.8:1, a step of;
The plant extract is a mixture of safflower extract and turmeric extract;
The mass ratio of the safflower extract to the turmeric extract is 1:3:2;
2. a preparation method of a cow nipple disinfectant comprises the following steps:
(1) Weighing iodine and potassium iodide, and dissolving in 30 parts of distilled water to obtain an iodine solution;
(2) Adding high molecular polymer into the rest 40 parts of distilled water, heating to 85 ℃, condensing, refluxing, stirring and dissolving; cooling to room temperature, adding a thickener and a hydroxyl compound, and fully dissolving to obtain a mixed solution;
(3) Adding the iodine solution, the emollient, the calcium-containing compound, the alum and the plant extract obtained in the step (1) into the mixed solution obtained in the step (2), and fully stirring and dissolving to obtain the cow nipple disinfectant.
Comparative example 2:
1. The cow nipple disinfectant comprises the following preparation raw materials in parts by weight: 2 parts of iodine, 8 parts of potassium iodide, 7 parts of hydroxyl compound, 4 parts of high molecular polymer, 2 parts of thickener, 2 parts of emollient, 0.3 part of calcium-containing compound, 2 parts of alum, 11 parts of plant extract and 70 parts of distilled water.
The hydroxyl compound is a mixture of glycerol and polyethylene glycol 400;
the mass ratio of the glycerol to the polyethylene glycol 400 is 1:1, a step of;
The high molecular polymer is a mixture of polyvinylpyrrolidone and polyvinyl alcohol;
the mass ratio of the polyvinylpyrrolidone to the polyvinyl alcohol is 9:1, a step of;
The viscosity average molecular weight of the polyvinyl alcohol is 12000-16800, the viscosity is 3.0-4.5 Pa.s, and the alcoholysis degree is 86-90%;
The thickener is xanthan gum;
the emollient is polyethylene glycol olive oil ester and sodium diisooctyl succinate;
The mass ratio of the polyethylene glycol olive oil ester to the sodium diisooctyl succinate is 1:1.2;
The calcium-containing compound is calcium chloride and calcium gluconate;
the mass ratio of the calcium chloride to the calcium gluconate is 0.8:1, a step of;
the plant extract is a mixture of safflower extract and dandelion extract;
the mass ratio of the safflower extract to the dandelion extract is 1:2;
2. a preparation method of a cow nipple disinfectant comprises the following steps:
(1) Weighing iodine and potassium iodide, and dissolving in 30 parts of distilled water to obtain an iodine solution;
(2) Adding high molecular polymer into the rest 40 parts of distilled water, heating to 85 ℃, condensing, refluxing, stirring and dissolving; cooling to room temperature, adding a thickener and a hydroxyl compound, and fully dissolving to obtain a mixed solution;
(3) Adding the iodine solution, the emollient, the calcium-containing compound, the alum and the plant extract obtained in the step (1) into the mixed solution obtained in the step (2), and fully stirring and dissolving to obtain the cow nipple disinfectant.
Comparative example 3:
1. The cow nipple disinfectant comprises the following preparation raw materials in parts by weight: 2 parts of iodine, 8 parts of potassium iodide, 7 parts of hydroxyl compound, 4 parts of high molecular polymer, 2 parts of emollient, 0.3 part of calcium-containing compound, 2 parts of alum, 11 parts of plant extract and 70 parts of distilled water.
The hydroxyl compound is a mixture of glycerol and polyethylene glycol 400;
the mass ratio of the glycerol to the polyethylene glycol 400 is 1:1, a step of;
The high molecular polymer is a mixture of polyvinylpyrrolidone and polyvinyl alcohol;
the mass ratio of the polyvinylpyrrolidone to the polyvinyl alcohol is 9:1, a step of;
The viscosity average molecular weight of the polyvinyl alcohol is 12000-16800, the viscosity is 3.0-4.5 Pa.s, and the alcoholysis degree is 86-90%;
the emollient is polyethylene glycol olive oil ester and sodium diisooctyl succinate;
The mass ratio of the polyethylene glycol olive oil ester to the sodium diisooctyl succinate is 1:1.2;
The calcium-containing compound is calcium chloride and calcium gluconate;
the mass ratio of the calcium chloride to the calcium gluconate is 0.8:1, a step of;
the plant extract is a mixture of safflower extract, turmeric extract and dandelion extract;
the mass ratio of the safflower extract to the turmeric extract to the dandelion extract is 1:3:2;
2. a preparation method of a cow nipple disinfectant comprises the following steps:
(1) Weighing iodine and potassium iodide, and dissolving in 30 parts of distilled water to obtain an iodine solution;
(2) Adding high molecular polymer into the rest 40 parts of distilled water, heating to 85 ℃, condensing, refluxing, stirring and dissolving; cooling to room temperature, adding a thickener and a hydroxyl compound, and fully dissolving to obtain a mixed solution;
(3) Adding the iodine solution, the emollient, the calcium-containing compound, the alum and the plant extract obtained in the step (1) into the mixed solution obtained in the step (2), and fully stirring and dissolving to obtain the cow nipple disinfectant.
Performance test:
1. Sterilization experiment: the test is carried out according to quantitative sterilization standards in the national standard for identification of veterinary disinfectants (1992) in the agricultural (grazing) word 101 issued by the Ministry of agriculture.
The sterilization rate of the cow nipple disinfectant obtained in the implementation 1 and 2 is 99.99 percent; the sterilization rate of the cow nipple disinfectant obtained in comparative examples 1 to 3 was 99.88%.
2. Stability test: the test was carried out according to the stability test method of the Ministry of health, disinfection Specification (2002 edition). After 3 months of storage at 37 ℃, the content of available iodine (i.e. iodine) is measured;
The average reduction rate of the effective iodine content of the cow nipple disinfectant obtained in the examples 1 and 2 is less than 3.3%, and the average reduction rate of the effective iodine content of the cow nipple disinfectant obtained in the comparative example 1 is 6.8%; the average decrease rate of the effective iodine content of the cow nipple disinfectant obtained in comparative example 2 was 7.0%, and the average decrease rate of the effective iodine content of the cow nipple disinfectant obtained in comparative example 3 was 6.1%.
3. Film forming time test: the test tube is inserted into the cow nipple disinfectant prepared in the examples and the comparative examples, the disinfectant is dipped in the disinfectant to be naturally dried, and the film forming time and the film forming state are observed and recorded;
Examples 1 and 2 can form a complete, non-porous and ductile protective film within 1 min; comparative examples 1,2 formed a complete, void-free, flexible protective film at 8 min; comparative example 3 forms a complete, non-porous film at 15min, but the film is more brittle.
Claims (2)
1. The cow nipple disinfectant is characterized by comprising the following raw materials in parts by weight: 1-3 parts of iodine, 6-10 parts of potassium iodide, 5-10 parts of hydroxyl compound, 2-6 parts of high molecular polymer, 1-3 parts of thickener, 1-3 parts of emollient, 0.1-0.5 part of calcium-containing compound, 1-3 parts of alum, 8-15 parts of plant extract and 60-80 parts of distilled water;
the plant extract is a mixture of safflower extract, turmeric extract and dandelion extract; the mass ratio of the safflower extract to the turmeric extract to the dandelion extract is 1: (2-5): (1-3);
The high molecular polymer is a mixture of polyvinylpyrrolidone and polyvinyl alcohol; the viscosity average molecular weight of the polyvinyl alcohol is 10000-18000, the viscosity is 2.0-5.0 Pa.s, and the alcoholysis degree is 77-95%;
The hydroxyl compound is glycerol and polyethylene glycol 400;
The thickener is xanthan gum;
the emollient is polyethylene glycol olive oil ester and sodium diisooctyl succinate;
The calcium-containing compound is calcium chloride and calcium gluconate.
2. A method of preparing the cow teat disinfectant as set forth in claim 1, comprising the steps of:
(1) Weighing iodine and potassium iodide, and dissolving in part of distilled water to obtain iodine solution;
(2) Adding high molecular polymer into the rest distilled water, heating to 70-95 ℃, condensing, refluxing, stirring and dissolving; cooling to room temperature, adding a thickener and a hydroxyl compound, and fully dissolving to obtain a mixed solution;
(3) Adding the iodine solution, the emollient, the calcium-containing compound, the alum and the plant extract obtained in the step (1) into the mixed solution obtained in the step (2), and fully stirring and dissolving to obtain the cow nipple disinfectant.
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