CN115737604A - High-stability organic acid medicinal bath liquid for livestock and preparation method thereof - Google Patents

Abstract

The invention discloses a highly stable veterinary organic acid medicinal bath liquid and a preparation method thereof, belonging to the technical field of disinfectants. Include the following components by weight: 1-10 parts of organic acid, 1-15 parts of stabilizer I, 1-5 parts of stabilizer II, 0.1-3 parts of thickener, 1-20 parts of emollient, pH regulator 0‑3 parts, 0‑1 part of essence, 0‑1 part of pigment. The present invention uses organic acid as the main bactericidal component, and introduces stabilizer I and stabilizer II, which can increase the solubility of organic acid, effectively prevent the decomposition of organic acid, and improve the bactericidal effect of organic acid. At the same time, nonionic surfactants can reduce surface tension, improve dispersibility and wettability, better and faster wet the skin surface, and improve the cleaning effect on cow teats.

Description

A kind of highly stable veterinary organic acid medicinal bath liquid and preparation method thereof

technical field

The invention relates to the technical field of disinfectants, in particular to a highly stable veterinary organic acid bath liquid and a preparation method thereof.

Background technique

Dairy farms are the main supply bases of dairy products and meat products. During the breeding process of dairy cows, mastitis is prone to occur due to bacterial and fungal infections, which affects the milk production and reproductive efficiency of dairy cows, and even death and infection of dairy cows occur, which brings great harm to the pasture. A lot of economic loss came. Existing bacterial defenses for cow teats mainly use disinfectants and medicated bath liquids. The disinfectants mainly use iodine disinfectants, such as povidone iodine, iodine glycerin, iodine glycerin teat infusion, and chlorhexidine and guanidine are also used for disinfection. Agents, acidic disinfectants and traditional Chinese medicine disinfectants.

Acidic disinfectants mainly include organic acids and inorganic acids. Inorganic acids mainly use hypochlorous acid, acid potential water, phosphoric acid, etc. as the main bactericidal components. Simultaneously there are also dipping liquids that partly adopt organic acids as the main bactericidal components, such as a kind of veterinary organic acid dipping liquid disclosed in publication number CN107281173A and its preparation method, wherein the dipping combination is 1-5 parts of potassium sorbate, lactic acid 5-15 parts, 0-2 parts of hydroxyethylidene diphosphonic acid (HEDP), 0-1 part of sodium polyacrylate, 5-10 parts of sodium lauryl sulfate; this technical scheme uses lactic acid as the main bactericidal component, With thickening and film forming, sodium lauryl sulfate is added as solubilizing and washing effect, and ethyl paraffin is used as antioxidant, but the storage stability is poor, and the organic acid content decreases quickly, and it is easy to lose Effect. Publication number CN1780564A discloses acid composition and its application, wherein organic acid and acidulant, organic acid is selected from propionic acid, lactic acid, acetic acid, butyric acid, citric acid, glycolic acid, pyruvic acid, ascorbic acid, benzoic acid, sorbic acid, Gluconic acid and its mixture, the acidifying agent is inorganic acid, although this technical scheme is with organic acid as main disinfectant, film-forming property is poor, easily low, is not suitable for the persistent bactericidal effect of medicated bath. Publication number CN108403671A discloses a povidone-iodine solution and its preparation method, which includes 0.1g-3g of elemental iodine, 1g-5g of PVP, 1g-10g of polyvinyl alcohol, 2g-10g of polyurethane, 0.1g-5g of sodium alginate, 0.2g-5g of organic acid, 5g-35g of surfactant, and 1g-3g of plasticizer. Although organic acid and surfactant are also included, the main bactericidal component is iodine, and the function of organic acid is mainly chelation. Publication No. EP3366279A1 discloses a disinfectant and film-forming composition for use after milking, containing lactic acid, which mainly includes 5.4-11% lactic acid as a disinfectant active substance, and also includes 1.955-4.45% nonionic surfactant, But in this technical scheme, the disinfectant is easy to drip after spraying, which reduces the bactericidal effect and persistence.

To sum up, the existing milk teat dips for dairy cows seldom use organic acids as the main bactericidal components, and the storage stability of organic acids is poor, and they are easy to deteriorate, so the bactericidal effect is poor and the bactericidal effect is not long-lasting.

Contents of the invention

In order to solve the above problems, the present invention proposes a high-stable veterinary organic acid bath liquid with organic acid as the main bactericidal component. Through a special proportion, the organic acid can have long-term storage stability and maintain the bactericidal effect. Persistence.

In order to achieve the above object, the present invention is achieved through the following technical solutions:

A highly stable veterinary organic acid dipping liquid, comprising the following components by weight: 1-10 parts of organic acid, 1-15 parts of stabilizer I, 1-5 parts of stabilizer II, and 0.1-3 parts of thickener 1-20 parts of emollient, 0-3 parts of pH regulator, 0-1 part of essence, and 0-1 part of pigment.

Further, the high-stable veterinary organic acid bath liquid comprises the following components by weight: 5-10 parts of organic acid, 1-15 parts of stabilizer I, 2-5 parts of stabilizer II, and 1-2 parts of thickener , 10-15 parts of emollient, 0-3 parts of pH regulator, 0-1 part of essence, and 0-1 part of pigment.

Further, the organic acid is one or more of oxalic acid, malic acid, benzoic acid, salicylic acid, sorbic acid, citric acid, phosphoric acid, sorbic acid, lactic acid, sulfamic acid, formic acid and propionic acid.

Preferably, the organic acid contains at least lactic acid.

Further, the stabilizer I is fatty alcohol polyoxyethylene ether, octylphenol polyoxyethylene ether-10, nonylphenol polyoxyethylene ether, cocamidopropyl amine oxide, sodium α-olefin sulfonate any one or more of them.

Preferably, the fatty alcohol polyoxyethylene ether is fatty alcohol polyoxyethylene ether-9.

Further, the stabilizer II is any one of decanol, dodecanol and myristyl alcohol.

Further, the thickener is one or more of gum arabic, xanthan gum, sodium alginate, sodium carboxymethylcellulose, hypromellose, pectin, and guar gum.

Further, the emollient is one or more of glycerin, polyethylene glycol, sodium hyaluronate, urea, sodium lactate, propylene glycol, sorbitol, butylene glycol, sodium pyrrolidone carboxylate, trehalose, and the like.

The present invention also discloses a preparation method of a high-stability veterinary organic acid medicinal bath liquid, comprising the following steps:

(1) Pre-foam the thickener with a small amount of water to disperse the thickener evenly in water;

(2) Mix water with the pre-foamed thickener, add emollient, pigment, essence, organic acid and stabilizer II sequentially under stirring, and stir to fully dissolve;

(3) Use a pH regulator to adjust the pH of the solution to 2-4, add stabilizer I, replenish water to 100 parts, stir and react for 0.5-1 hour, stand still and defoam.

The present invention has high-stable veterinary organic acid dipping liquid and its preparation method, and its beneficial effects are:

(1) The present invention uses organic acid as the main bactericidal component, and introduces stabilizer I and stabilizer II, and stabilizer I is a nonionic surfactant, especially fatty alcohol polyoxyethylene ether-9 (that is, fatty alcohol polyoxyethylene Vinyl ether AEO-9), fatty alcohol polyoxyethylene ether-9 is a colorless transparent viscous liquid with good emulsification performance, and can increase the solubility of organic acids, effectively prevent the decomposition of organic acids, and improve the sterilization of organic acids Effect. At the same time, nonionic surfactants can reduce surface tension, improve dispersibility and wettability, better and faster wet the skin surface, and improve the cleaning effect on cow teats.

(2) the present invention also adds stabilizing agent II, and stabilizing agent II is based on organic alcohol, and the organic alcohol that the present invention adds especially lauryl alcohol (lauryl alcohol) and myristyl alcohol (myristyl alcohol) are all insoluble in water , After the solution system is fully mixed with the aqueous solution to form a micellar structure, thereby stabilizing the entire solution, the micellar structure of the entire solution is stabilized at 30-60 ° C, mixed with non-ionic surfactants, can stably improve the non-ionic surface The emulsifying properties of the active agent make the colloidal properties of the whole solution more stable, the thermal stability is better, and the instability and failure of the organic acid as a dipping solution are improved.

(3) The present invention adds a thickener, which can make the solution contact with the skin to form a film quickly, prevent the solution from dripping, and can further prevent the decomposition of the organic acid at the same time, so that the organic acid can form a long-term effect on the surface of the cow's udder. antibacterial protective film.

(4) The present invention adds an emollient, which can effectively protect the cow's udder and prevent bacterial infection.

Detailed ways

In order to enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, not all the embodiment. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

A highly stable veterinary organic acid dipping liquid, characterized in that it includes the following components in parts by weight: 5-10 parts of organic acid, 1-15 parts of stabilizer I, 1-5 parts of stabilizer II, and a thickener 0.1-3 parts, 1-20 parts of emollient, 0-3 parts of pH regulator, 0-1 part of essence, 0-1 part of pigment.

It should be noted that the organic acid is one or more of oxalic acid, malic acid, benzoic acid, salicylic acid, sorbic acid, citric acid, phosphoric acid, sorbic acid, lactic acid, sulfamic acid, formic acid, and propionic acid. Organic acid sterilization is mainly achieved by reducing the pH value of the bacterial environment, because most pathogenic microorganisms (such as Campylobacter, Clostridium perfringens, Escherichia coli) cannot tolerate an environmental pH value lower than 4.5. And the organic acid of the present invention is preferably lactic acid, and lactic acid can be used as the organic acid of non-dissociation, enters in bacterial cell by free diffusion mode, dissociates carboxyl ion and H+ ion then, and carboxyl ion has the effect of inhibiting DNA replication, inhibiting protein synthesis and Destroy the function of the bacterial cell membrane, thereby inhibiting the generation of the next generation of bacteria; and the dissociated H+ will reduce the pH value in the bacterial cells, and the bacteria need energy to deacidify. The specific organic acid of the present invention achieves sterilization through two mechanisms.

It is worth noting that lactic acid has a relatively large molecular weight, and it is difficult to enter the cell wall under normal circumstances, so a higher concentration of lactic acid is required. However, the present invention can solubilize the acid by adding the nonionic surfactant of the stabilizer I, and at the same time improve skin penetration, promote the entry of lactic acid molecules into the skin, and achieve the purpose of high-efficiency sterilization.

Preferably, as an embodiment, a high-stability veterinary organic acid bath liquid is characterized in that: it includes the following components in parts by weight: 1-5 parts of lactic acid, 1-15 parts of stabilizer I, stabilizer II 1-5 parts, 0.1-3 parts of thickener, 1-20 parts of emollient, 0-3 parts of pH regulator, 0-1 part of essence, 0-1 part of pigment.

Preferably, as an embodiment, a high-stability veterinary organic acid dipping solution is characterized in that: it comprises the following components in parts by weight: 5-10 parts of organic acid, 1-15 parts of stabilizer, stabilizer 1-5 parts of II, 0.1-3 parts of thickener, 1-20 parts of emollient, 0-3 parts of pH regulator, 0-1 part of essence, and 0-1 part of pigment. In this embodiment, the organic acid is one or more of oxalic acid, malic acid, benzoic acid, salicylic acid, sorbic acid, citric acid, phosphoric acid, sorbic acid, sulfamic acid, formic acid and propionic acid.

It should be noted that the stabilizer I is fatty alcohol polyoxyethylene ether, octylphenol polyoxyethylene ether-10, nonylphenol polyoxyethylene ether, cocamidopropylamine oxide, sodium α-olefin sulfonate any one or more of them. Preferably any one of fatty alcohol polyoxyethylene ether-7, fatty alcohol polyoxyethylene ether-9, octylphenol polyoxyethylene ether-10, cocamidopropylamine oxide, and sodium α-alkenyl sulfonate .

It should be noted that the stabilizer II is any one of decanol, dodecyl alcohol, and myristyl alcohol.

It should be noted that the thickener is one or more of gum arabic, xanthan gum, sodium alginate, sodium carboxymethylcellulose, hypromellose, pectin, and guar gum. The thickener is mainly a skin-friendly film-forming substance, which can effectively prevent the dipping liquid from dripping, thereby prolonging the bactericidal effect of the dipping liquid.

It should be noted that the emollient is one or more of glycerin, polyethylene glycol, sodium hyaluronate, urea, sodium lactate, propylene glycol, sorbitol, butylene glycol, sodium pyrrolidone carboxylate, trehalose, and the like. Emollients moisturize the skin and enhance skin care.

It should be noted that the pH regulator is mainly one or more of sodium hydroxide, citric acid, sodium citrate, phosphoric acid, and sodium dihydrogen phosphate. Mainly adjust the pH value of the whole solution to keep the pH value at 2-4.

It should be noted that the essence mainly increases the fragrance of the product, so that the sense of smell of cows and staff will not be stimulated. The pigment is mainly used to distinguish colorless and colored. For colored solutions, no pigment is added, while for colorless solutions, pigments need to be added to distinguish, which is convenient for observation.

A preparation method of highly stable veterinary organic acid dipping liquid, comprising the following steps:

(1) Pre-foam the thickener with a small amount of water for 18-32 hours, the time is not fixed, just foam and disperse evenly;

(2) Mix water with the pre-foamed thickener, add emollient, pigment, essence, organic acid and stabilizer II sequentially under stirring, and stir to fully dissolve;

(3) Use a pH regulator to adjust the pH of the solution to 3.5, add stabilizer I, replenish water to 100 parts, stir and react for 0.5-1 hour, stand still and defoam.

Example 1

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 5 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of lauryl alcohol, 1 part of pectin, and 5 parts of glycerin , 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 2

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of malic acid, 5 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of lauryl alcohol, 1 part of pectin, 5 parts of glycerin 1 part, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 3

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of citric acid, 5 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of lauryl alcohol, 1 part of pectin, glycerin 5 parts, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 4

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of salicylic acid, 5 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of lauryl alcohol, 1 part of pectin, glycerin 5 parts, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 5

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of sorbic acid, 5 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of lauryl alcohol, 1 part of pectin, 5 parts of glycerin 1 part, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 6

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of oxalic acid, 5 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of lauryl alcohol, 1 part of pectin, and 5 parts of glycerin , 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 7

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of phosphoric acid, 5 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of lauryl alcohol, 1 part of pectin, and 5 parts of glycerin , 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 8

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 3 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of decanol, 1 part of pectin, 5 parts of glycerin, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 9

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 1 part of fatty alcohol polyoxyethylene ether-9, 2 parts of decanol, 1 part of pectin, 5 parts of glycerin, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 10

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 1 part of octylphenol polyoxyethylene ether-10, 2 parts of decanol, 1 part of pectin, 5 parts of glycerin 1 part, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 11

A highly stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 1 part of cocamidopropylamine oxide, 2 parts of decanol, 1 part of pectin, 5 parts of glycerin, sorbic acid 5 parts of alcohol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 12

A highly stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 5 parts of cocamidopropylamine oxide, 2 parts of decanol, 1 part of pectin, 5 parts of glycerin, sorbic acid 5 parts of alcohol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 13

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 5 parts of octylphenol polyoxyethylene ether-10, 2 parts of decanol, 1 part of pectin, 5 parts of glycerin 1 part, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 14

A highly stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 5 parts of sodium α-alkenyl sulfonate, 2 parts of decanol, 1 part of pectin, 5 parts of glycerin, sorbic acid 5 parts of alcohol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 15

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of phosphoric acid, 5 parts of fatty alcohol polyoxyethylene ether-7, 2 parts of myristyl alcohol, 1 part of pectin, and 5 parts of glycerin , 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 16

A highly stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of formic acid, 3 parts of sodium α-alkenyl sulfonate, 2 parts of myristyl alcohol, 1 part of xanthan gum, and 5 parts of glycerin , 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 17

A highly stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of sulfamic acid, 1 part of sodium α-alkenyl sulfonate, 3 parts of myristyl alcohol, 1 part of sodium hydroxymethyl cellulose 1 part, 5 parts of propylene glycol, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 18

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of propionic acid, 2 parts of octylphenol polyoxyethylene ether-10, 3 parts of myristyl alcohol, 1 part of guar gum 5 parts of glycerin, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 19

A highly stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of caprylic acid, 3 parts of cocamidopropylamine oxide, 3 parts of myristyl alcohol, 1 part of xanthan gum, and 5 parts of glycerin , 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 20

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 8 parts of phosphoric acid, 3 parts of octylphenol polyoxyethylene ether-10, 3 parts of myristyl alcohol, 1 part of pectin, urea 5. 3 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 21

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of phosphoric acid, 1 part of cocamidopropyl amine oxide, 3 parts of myristyl alcohol, 1 part of gum arabic, 3 parts of butanediol 10 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 22

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of phosphoric acid, 4 parts of fatty alcohol polyoxyethylene ether-9, 3 parts of myristyl alcohol, 1 part of sodium alginate, hyaluronic acid 7 parts of sodium nitrate, 5 parts of trehalose, 1 part of essence, 1 part of pigment, and the balance is water.

Example 23

A highly stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of phosphoric acid, 2 parts of fatty alcohol polyoxyethylene ether-9, 3 parts of myristyl alcohol, 1 part of gum arabic, and 8 parts of urea , 10 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 24

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 5 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of decanol, 1 part of pectin, 5 parts of glycerin, 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Example 25

A high-stable veterinary organic acid dipping liquid, comprising the following components by weight: 5 parts of lactic acid, 5 parts of fatty alcohol polyoxyethylene ether-9, 2 parts of myristyl alcohol, 1 part of pectin, and 5 parts of glycerin , 5 parts of sorbitol, 1 part of essence, 1 part of pigment, and the balance is water.

Comparative example 1

The ratio of the same components as in Example 1 is the same, except that dodecanol is not added.

Comparative example 2

The same component ratio as in Example 1 is the same, except that fatty alcohol polyoxyethylene ether-9 is not added.

Comparative example 3

The same component ratio as in Example 1 is the same, except that fatty alcohol polyoxyethylene ether-9 and lauryl alcohol are not added.

Comparative example 4

The ratio of the same components as in Example 1 is the same, except that dodecanol is not added and replaced by ethanol.

Comparative example 5

The same component ratio as in Example 1 is the same, except that dodecanol is not added to replace propylene glycol.

Comparative example 6

The ratio of the same components is the same as in Example 1, except that fatty alcohol polyoxyethylene ether-9 is replaced by alkyl glycoside.

Comparative example 7

The same component ratio as in Example 1 is the same, except that fatty alcohol polyoxyethylene ether-9 is not added and replaced by coco betaine.

Comparative example 8

The ratio of the same components is the same as in Example 1, except that fatty alcohol polyoxyethylene ether-9 is replaced by Span-80.

Comparative example 9

The ratio of the same components is the same as in Example 1, except that fatty alcohol polyoxyethylene ether-9 is replaced by Tween-80.

Performance Testing

1. Organic acid stability test

Detection (test) method: According to the method for lactic acid content in the Veterinary Pharmacopoeia of the People's Republic of China (2020 Edition). Stability investigation: According to the "GB/T 38499-2020 Disinfectant Stability Evaluation Method" to inspect the product stability, the obtained data are shown in Table 1-Table 2:

Table 1 Comparative analysis of lactic acid content stability

Table 2 Lactic acid content (%) at different temperatures and storage time

It can be seen from the above examples that the present invention can stabilize the content of lactic acid in the solution through the specific non-ionic surfactant and organic alcohol, and its content is relatively small, and still has high-efficiency bactericidal performance.

From the comparison of Example 1, Example 24 and Example 25 with Comparative Example 1, it can be seen that the organic alcohols (decyl alcohol, dodecyl alcohol and myristyl alcohol) added in the present invention can all improve the stability of organic acids. At the same time, the stability of lauryl alcohol is more excellent.

From the comparison of Example 1 and Comparative Examples 1, 2, and 3, the addition of lauryl alcohol and fatty alcohol polyoxyethylene ether-9 alone can improve the stability of lactic acid to a certain extent, but the stability is small. Lauryl alcohol and fatty alcohol polyoxyethylene ether-9 can have a synergistic effect, greatly improving the stability of lactic acid, and ensuring the sterilization and cleaning effect of the organic acid solution.

From Example 1 and Comparative Examples 4 and 5, it can be seen that the small molecule alcohol has a certain improvement on the stability, but the improvement is not large. And adopt specific organic alcohol of the present invention, can improve the stability of lactic acid greatly.

From Example 1 and Comparative Examples 6, 7, 8 and 9, it can be seen that commonly used nonionic surfactants can improve the stability of organic acids to a certain extent, but the improvement is not large.

It can be seen from Table 2 that in Example 1 of the present invention, the lactic acid content can reach more than 4.5% at different temperatures of 20-60°C, which has a relatively high lactic acid content, low lactic acid decomposition rate, and the sterilization and cleaning effects are still maintained. .

2. Bactericidal performance test for different strains

Taking Examples 1-7 as detection objects, Staphylococcus aureus (initial colony concentration: 1.48*10 ⁶ cfu/ml), Escherichia coli (initial colony concentration: 2.41*10 ⁶ cfu/ml), agalactia Cocci (initial colony concentration: 2.29*10 ⁶ cfu/ml), Candida albicans (initial colony concentration: 4.81*10 ⁵ cfu/ml) and Pseudomonas aeruginosa (initial colony concentration: 3.06*10 ⁶ cfu /ml), according to the "Disinfection Technical Specifications" (2002 version), the bactericidal performance test was carried out, the action temperature was 26±1°C, and the incubation temperature was 36±1°C. The results obtained are shown in Table 3-Table 7;

Table 3 Bactericidal effect on Staphylococcus aureus

Table 4 Bactericidal effect on Escherichia coli

Table 5 Bactericidal effect on no streptococcus

Table 6 Bactericidal effect on Candida albicans

Table 7 to Pseudomonas aeruginosa bactericidal effect

It can be seen from Table 3-Table 7 that in Example 1, lactic acid is used as the main bactericidal component, and its bactericidal effect can be excellent at a low concentration of 0.5%, and high-efficiency sterilization can be achieved at 0.5%. Although the bactericidal effects of other organic acids have certain differences in initial concentration, they can all achieve good bactericidal performance at 5%.

Reference herein to an "embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the present invention. The occurrences of this phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is understood explicitly and implicitly by those skilled in the art that the embodiments described herein can be combined with other embodiments.

Finally, it should be noted that: what the embodiment of the present invention discloses is only the preferred embodiment of the present invention, and is only used to illustrate the technical solution of the present invention, not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments Those of ordinary skill in the art should understand that it is still possible to modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements do not make the corresponding technical solutions The essence of the invention deviates from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims (7)

1. A high-stability veterinary organic acid medicinal bath liquid is characterized in that: it comprises the following components by weight: 1-10 parts of organic acid, 1-15 parts of stabilizer I, 1-5 parts of stabilizer II, 0.1-3 parts of thickener, 1-20 parts of emollient, 0-3 parts of pH regulator, 0-1 part of essence, and 0-1 part of pigment. 2. according to the described high-stability veterinary organic acid dipping liquid of claim 1, it is characterized in that: described organic acid is oxalic acid, malic acid, benzoic acid, salicylic acid, sorbic acid, citric acid, phosphoric acid, sorbic acid , lactic acid, sulfamic acid, formic acid, propionic acid in one or more. 3. according to the described high-stability veterinary organic acid dipping liquid of claim 1, it is characterized in that: described stabilizer I is fatty alcohol polyoxyethylene ether, octylphenol polyoxyethylene ether-10, nonylphenol Any one or more of polyoxyethylene ether, cocamidopropyl amine oxide, and sodium α-alkenyl sulfonate. 4. The high-stability veterinary organic acid dipping liquid according to claim 1, characterized in that: the stabilizer II is any one of decanol, dodecanol, and myristyl alcohol. 5. according to the described high-stability veterinary organic acid dipping liquid of claim 1, it is characterized in that: described thickener is gum arabic, xanthan gum, sodium alginate, sodium carboxymethyl cellulose, hypromellose One or more of cellulose, pectin, and guar gum. 6. according to the described high-stability veterinary organic acid dipping liquid of claim 1, it is characterized in that: described emollient is glycerin, polyethylene glycol, sodium hyaluronate, urea, sodium lactate, propylene glycol, sorbitol, One or more of butanediol, sodium pyrrolidone carboxylate, trehalose, etc. 7. A preparation method according to claim 1, characterized in that: comprising the following steps: (1) Pre-foam the thickener with a small amount of water to disperse the thickener evenly in water; (2) Mix water with the pre-foamed thickener, add emollient, pigment, essence, organic acid and stabilizer II sequentially under stirring, and stir to fully dissolve; (3) Use a pH regulator to adjust the pH of the solution to 2-4, add stabilizer I, replenish water to 100 parts, stir and react for 0.5-1 hour, stand still and defoam.