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CN115698079A - 抗cd79b抗体药物偶联物、其制备方法及其医药用途 - Google Patents

抗cd79b抗体药物偶联物、其制备方法及其医药用途 Download PDF

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Publication number
CN115698079A
CN115698079A CN202180042603.6A CN202180042603A CN115698079A CN 115698079 A CN115698079 A CN 115698079A CN 202180042603 A CN202180042603 A CN 202180042603A CN 115698079 A CN115698079 A CN 115698079A
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drug conjugate
antibody drug
preparation
medical use
cd79b antibody
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Inventor
任文明
梁金栋
许建烟
黄建
杨昌永
廖成
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Shanghai Tuojie Biomedical Technology Co ltd
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Shanghai Tuojie Biomedical Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Abstract

涉及一种抗CD79B抗体药物偶联物、其制备方法及其医药用途。具体而言，提供一种抗体药物偶联物(ADC)，其包含与MMAE或其衍生物、依喜替康或其衍生物、或艾日布林或其衍生物缀合的抗CD79B抗体，含有所述ADC的药物组合物，及其在制备治疗CD79B介导的疾病或病症的药物中的用途，尤其在用于制备抗癌药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (51)

  1. PCT国内申请，权利要求书已公开。
CN202180042603.6A 2020-07-27 2021-07-27 抗cd79b抗体药物偶联物、其制备方法及其医药用途 Pending CN115698079A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN202010730899 2020-07-27
CN2020107308998 2020-07-27
CN202010735910 2020-07-28
CN202010735910X 2020-07-28
PCT/CN2021/108666 WO2022022508A1 (zh) 2020-07-27 2021-07-27 抗cd79b抗体药物偶联物、其制备方法及其医药用途

Publications (1)

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CN115698079A true CN115698079A (zh) 2023-02-03

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US (1) US20230405138A1 (zh)
EP (1) EP4190812A4 (zh)
JP (1) JP2023535598A (zh)
KR (1) KR20230044275A (zh)
CN (1) CN115698079A (zh)
AU (1) AU2021317378A1 (zh)
BR (1) BR112023001359A2 (zh)
CA (1) CA3184724A1 (zh)
MX (1) MX2023001163A (zh)
WO (1) WO2022022508A1 (zh)

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US20240382607A1 (en) * 2021-07-22 2024-11-21 Shanghai Senhui Medicine Co., Ltd. Drug conjugate of eribulin derivative
JP2024532295A (ja) * 2021-08-24 2024-09-05 クンシャン シンユンター バイオテック カンパニー，リミティド 切断可能なリンカーを介して結合した抗体薬物複合体
JP2024533356A (ja) * 2021-09-16 2024-09-12 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド 抗ｈｅｒ３抗体薬物複合体及びその組成物並びに用途
AU2023212240A1 (en) * 2022-01-26 2024-07-11 Shanghai Mabgen Biotech Ltd. Pharmaceutical composition comprising anti-cd79b antibody-drug conjugate and use thereof
WO2023155808A1 (zh) * 2022-02-16 2023-08-24 苏州宜联生物医药有限公司 抗体-艾日布林或其衍生物的偶联物、其中间体、制备方法、药物组合物和用途
JP2025508779A (ja) * 2022-02-24 2025-04-10 エボポイント、バイオサイエンシズ、カンパニー、リミテッド 抗体及びその薬物コンジュゲート並びに用途
KR20250049549A (ko) * 2022-08-08 2025-04-11 에이티비 테라퓨틱스 CD79b에 대한 인간화된 항체
KR20250084935A (ko) * 2022-10-14 2025-06-11 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. 링커-페이로드 화합물, 접합체 및 이의 응용 분야
CN117917248A (zh) * 2022-10-20 2024-04-23 英诺湖医药(杭州)有限公司 酶裂解连接子及包含其的配体-艾瑞布林偶联物
CN120239617A (zh) * 2022-11-22 2025-07-01 康诺亚生物医药科技（成都）有限公司 稠环类化合物及其偶联物和用途
WO2024213080A1 (zh) * 2023-04-12 2024-10-17 荣昌生物制药(烟台)股份有限公司 一种甲基奥瑞他汀e化合物的制备及纯化方法

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