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CN115697998A - 一种具有大范围斯托克斯位移的新型荧光化合物 - Google Patents

一种具有大范围斯托克斯位移的新型荧光化合物 Download PDF

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Publication number
CN115697998A
CN115697998A CN202180042636.0A CN202180042636A CN115697998A CN 115697998 A CN115697998 A CN 115697998A CN 202180042636 A CN202180042636 A CN 202180042636A CN 115697998 A CN115697998 A CN 115697998A
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CN
China
Prior art keywords
fluorescent compound
group
solution
stokes shift
compound
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Pending
Application number
CN202180042636.0A
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English (en)
Inventor
陈锦森
张有福
李竑
王建鹏
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Nanjing Jinsirui Science and Technology Biology Corp
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Nanjing Jinsirui Science and Technology Biology Corp
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Publication of CN115697998A publication Critical patent/CN115697998A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

本发明涉及荧光染料领域，具体涉及一种具有大范围斯托克斯位移的新型荧光化合物，所述荧光化合物可用于核酸和多肽修饰，且斯托克斯位移最大可达到约190nm，即最大发射波长与最大激发波长有了较大波长差，从而解决了测量中因串扰以及后向散射效应带来的自淬灭和测量误差的问题。

Description

PCT国内申请，说明书已公开。

Claims (25)

  1. PCT国内申请，权利要求书已公开。
CN202180042636.0A 2020-06-15 2021-06-15 一种具有大范围斯托克斯位移的新型荧光化合物 Pending CN115697998A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020105406040 2020-06-15
CN202010540604 2020-06-15
PCT/CN2021/100087 WO2021254321A1 (zh) 2020-06-15 2021-06-15 一种具有大范围斯托克斯位移的新型荧光化合物

Publications (1)

Publication Number Publication Date
CN115697998A true CN115697998A (zh) 2023-02-03

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CN202180042636.0A Pending CN115697998A (zh) 2020-06-15 2021-06-15 一种具有大范围斯托克斯位移的新型荧光化合物

Country Status (2)

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CN (1) CN115697998A (zh)
WO (1) WO2021254321A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024234959A1 (en) * 2023-05-18 2024-11-21 Versitech Limited Late-stage peptide cyclization to form disulfide mimetics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001094473A1 (en) * 2000-06-07 2001-12-13 Lightup Technologies Ab Solid phase synthesis of cyanine dyes
CN101142326A (zh) * 2005-03-17 2008-03-12 百奥提姆股份有限公司 二聚和三聚核酸染料以及相关的系统和方法
US20140206870A1 (en) * 2011-08-12 2014-07-24 Uti Limited Partnership Fluorscent dyes with large stokes shifts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001094473A1 (en) * 2000-06-07 2001-12-13 Lightup Technologies Ab Solid phase synthesis of cyanine dyes
CN101142326A (zh) * 2005-03-17 2008-03-12 百奥提姆股份有限公司 二聚和三聚核酸染料以及相关的系统和方法
US20140206870A1 (en) * 2011-08-12 2014-07-24 Uti Limited Partnership Fluorscent dyes with large stokes shifts

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SHUJI IKEDA等: "Hybridization-sensitive fluorescence control in the near-infrared wavelength range", 《ORGANIC & BIOMOLECULAR CHEMISTRY》, vol. 9, no. 11, 25 March 2011 (2011-03-25), pages 4199 - 4204, XP055822137, DOI: 10.1039/c1ob05252g *
SHUWEI ZHANG 等: "A water-soluble near-infrared fluorescent probe for sensitive and selective detection of cysteine", 《TALANTA》, vol. 204, 19 June 2019 (2019-06-19), pages 747 - 752, XP085747178, DOI: 10.1016/j.talanta.2019.06.074 *
YANPENG DAI等: "A novel fluorescent probe for rapidly detection cysteine in cystinuria urine, living cancer/normal cells and BALB/c nude mice", 《SPECTROCHIMICA ACTA PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY》, vol. 225, 27 August 2019 (2019-08-27), pages 117490, XP085961493, DOI: 10.1016/j.saa.2019.117490 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024234959A1 (en) * 2023-05-18 2024-11-21 Versitech Limited Late-stage peptide cyclization to form disulfide mimetics

Also Published As

Publication number Publication date
WO2021254321A1 (zh) 2021-12-23

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