CN115671425A - Blood purification equipment and storage medium - Google Patents

Abstract

The present invention provides a blood purification apparatus and a storage medium, a pressure sensor of the blood purification apparatus measures a liquid pressure of an elongated tube to obtain pressure measurement data, the storage medium stores program instructions executable by a processor, the processor is capable of executing: outputting the replacement liquid to the slender pipe according to the pre-flushing starting instruction; calculating the pressure variation of the replacement fluid and the pressure variation time of the replacement fluid according to the pressure measurement data; determining viscosity system parameters according to the viscosity of the preset replacement liquid, the pressure variation of the replacement liquid and the pressure variation time of the replacement liquid; dialyzing the blood through a dialyzer according to a blood treatment instruction, and conveying the dialyzed blood to the slender pipe; calculating a first blood pressure change amount and a first blood pressure change time according to the pressure measurement data; a first blood viscosity is determined based on the viscosity system parameter, the first blood pressure change amount, and the first blood pressure change time. The invention solves the problem that the blood viscosity can not be detected in the hemodialysis treatment process.

Description

A blood purification device and storage medium

technical field

The present invention relates to the technical field of blood purification, in particular, to a blood purification device and a storage medium.

Background technique

Blood purification equipment draws human blood out of the body, then filters out specific molecular substances in the blood, and then returns the purified blood to the human body to achieve the effect of disease treatment. Blood purification treatment methods can be divided into hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion, plasma exchange, immunoadsorption, peritoneal dialysis and other treatment modes according to the principle of blood purification. Different blood purification treatment modes are suitable for different clinical symptoms, such as acute and chronic renal failure with unstable cardiovascular function, hypercatabolism or cerebral fluid, multiple organ dysfunction syndrome, acute respiratory distress syndrome syndrome, crush syndrome, acute necrotizing pancreatitis, chronic heart failure, hepatic encephalopathy, drug and poison poisoning and other diseases.

Blood purification treatment needs to rely on blood purification equipment to perform. Taking the hemodialysis treatment mode as an example, the patient's blood and dialysate with standard ion concentration are introduced into the dialyzer at the same time. The dialysate and blood are on both sides of the hollow fiber membrane. The diffusion, convection, and ultrafiltration functions of the fibrous membrane remove excess water from the patient's body at an appropriate speed, and achieve the purpose of correcting water, electrolyte, and acid-base balance. In order to ensure the safety of patients during hemodialysis treatment, real-time monitoring of hemodynamic parameters during hemodialysis treatment can effectively suppress complications such as high blood pressure and vascular atrophy caused by severe dehydration during dialysis. As one of the hemodynamic parameters, blood viscosity is an important indicator reflecting the nature of blood flow. Normal blood viscosity is an important condition to ensure the normal circulation of extracorporeal blood. When blood viscosity increases during extracorporeal blood circulation, this can lead to problems such as coagulation, thrombus, and cardiovascular-related complications.

In the prior art, when measuring the blood viscosity of a patient, the blood routine or blood viscosity of the patient can only be tested before or after dialysis, and the viscosity tester and hematometer are used for testing during the test. If the patient's blood viscosity cannot be detected during the hemodialysis treatment, the user cannot evaluate the patient's hemodialysis treatment according to the detected blood viscosity, which not only reduces the practical value and reliability of the blood viscosity measurement process, but also reduces the patient's need for hemodialysis. The safety of treatment.

Contents of the invention

The invention aims to solve the problem in the prior art that blood viscosity cannot be detected during hemodialysis treatment.

In order to solve the above problems, the first aspect of the present invention provides a blood purification device, the blood purification device includes: a slender tube, a power assembly, a dialyzer, an arterial line, a venous line, a pressure sensor, a processor, and a memory , the arterial line is connected to the blood input end of the dialyzer, the venous line is connected to the blood output end of the dialyzer, and the first end of the elongated tube is connected to the venous line, The second end of the elongated tube is connected to the power assembly, and the processor is electrically connected to the memory and the pressure sensor through a bus;

The pressure sensor is used to measure the liquid pressure of the elongated tube to obtain pressure measurement data;

The memory stores program instructions executable by the processor, and the processor calls the program instructions to perform the following methods:

Outputting the replacement fluid to the arterial line, the dialyzer, and the venous line, and outputting the replacement fluid to the elongated tube through the power assembly according to the preflush start command output by the user;

calculating the displacement fluid pressure change amount of the elongated tube and the displacement fluid pressure change time of the elongated tube according to the pressure measurement data;

determining the parameters of the viscosity system according to the preset viscosity of the replacement fluid, the amount of change in pressure of the replacement fluid in the elongated tube, and the change time of the pressure of the replacement fluid in the elongated tube;

Dialyze the blood through the dialyzer according to the blood therapy instruction output by the user, and output the dialyzed blood to the elongated tube through the power assembly;

calculating a first blood pressure change amount of the elongated tube and a first blood pressure change time of the elongated tube according to the pressure measurement data;

The first blood viscosity is determined according to the viscosity system parameter, the first blood pressure change amount of the elongated tube, and the first blood pressure change time of the elongated tube.

The second aspect of the present invention provides a computer-readable storage medium, on which a computer program is stored, and when the computer program is executed by a processor, the following method is implemented:

Output the replacement fluid to the arterial line, dialyzer, and venous line according to the preflush start command output by the user, and output to the slender tube through the power component;

calculating the displacement fluid pressure change amount of the elongated tube and the displacement fluid pressure change time of the elongated tube according to the pressure measurement data;

determining the parameters of the viscosity system according to the preset viscosity of the replacement fluid, the amount of change in pressure of the replacement fluid in the elongated tube, and the change time of the pressure of the replacement fluid in the elongated tube;

Dialyze the blood through the dialyzer according to the blood therapy instruction output by the user, and output the dialyzed blood to the elongated tube through the power assembly;

calculating a first blood pressure change amount of the elongated tube and a first blood pressure change time of the elongated tube according to the pressure measurement data;

The first blood viscosity is determined according to the viscosity system parameter, the first blood pressure change amount of the elongated tube, and the first blood pressure change time of the elongated tube.

The blood purification equipment and computer-readable storage medium provided by the present invention use the operation steps in the hemodialysis process to obtain the necessary viscosity system parameters in the viscosity detection process in the preflushing stage in advance, so as to facilitate the later calculation process of blood viscosity. Data basis, when the patient undergoes hemodialysis, it is convenient to accurately calculate the blood viscosity of the patient. The present invention perfectly combines the blood viscosity detection with the hemodialysis process, effectively integrates the viscosity detection into the hemodialysis process, and can be used in the blood treatment stage. Real-time detection and monitoring of the patient's blood viscosity has strong practicality and convenience; in addition, the present invention skillfully utilizes the pressure change with time when the fluid medium is inhaled, thereby determining the blood viscosity method, which can effectively obtain the blood viscosity value, The detection cost is low, the detection feasibility is high, the detection reliability is high, and the blood viscosity can be detected in real time during the hemodialysis process, so that the medical staff can refer to the evaluation process of the hemodialysis effect according to the blood viscosity, and avoid the occurrence of cardiovascular disease in patients. And other related complications, so as to further ensure the safety of patients undergoing hemodialysis, and overcome the problem in the prior art that the patient's blood viscosity cannot be detected during hemodialysis, resulting in low safety of patients' hemodialysis treatment.

Description of drawings

Fig. 1 is a schematic diagram of the first structure of the blood purification equipment provided in the embodiment of the present invention;

Fig. 2 is a second structural schematic diagram of the blood purification equipment provided in the embodiment of the present invention;

Fig. 3 is a schematic diagram of the third structure of the blood purification equipment provided in the embodiment of the present invention;

Fig. 4 is a schematic flowchart of a method executed by a processor of a blood purification device provided in an embodiment of the present invention;

Fig. 5 is a schematic diagram of the variation curve of the first blood viscosity with time in the embodiment of the present invention;

Fig. 6 is a schematic diagram of the change curve of the target dehydration amount and the second blood viscosity in the embodiment of the present invention;

Fig. 7 is a schematic structural diagram of the display screen of the blood purification device provided in the embodiment of the present invention.

Explanation of reference signs:

1-slender tube; 2-power component; 3-dialyzer; 4-arterial line; 5-venous line; 6-pressure sensor; 7-blood detector; 8-blood pump; 9-heparin pump; 10 -first fluid storage bag; 11-second fluid storage bag; 12-third fluid storage bag; 13-filtration pump; 14-dialysis fluid pump; 15-replacement fluid pump; 16-venous pot; 17-fluid level Detector; 18-pre-displacement; 19-post-displacement; 20-first heater; 21-first cut-off detector; 22-leakage detector; 23-second heater; 24-second cut-off detection device; 25-bubble detector; 26-display.

Detailed ways

The technical solution of the present application and how the technical solution of the present application solves the above technical problems will be described in detail below with specific embodiments. The following specific embodiments may be combined with each other, and the same or similar concepts or processes may not be repeated in some embodiments. Embodiments of the present application will be described below in conjunction with the accompanying drawings.

It should be noted that examples of embodiments of the present application are shown in the drawings, wherein the same or similar reference numerals represent the same or similar elements or elements having the same or similar functions. The embodiments described below by referring to the figures are exemplary only for explaining the present application, and are not construed as limiting the present application.

Those skilled in the art will understand that the singular forms "a", "an" and "the" used herein may also include plural forms unless otherwise stated. It should be further understood that the word "comprising" used in the description of the present application refers to the presence of features, integers, steps, operations, elements and/or components, but does not exclude the presence or addition of one or more other features, integers, Steps, operations, elements, components and/or groups thereof. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Additionally, "connected" or "coupled" as used herein may include wireless connection or wireless coupling. The expression "and/or" used herein includes all or any elements and all combinations of one or more associated listed items.

Referring to Fig. 1 and Fig. 2, Fig. 1 is a schematic structural diagram of an embodiment of the blood purification device in the embodiment of the present application, and Fig. 2 is a schematic structural diagram of another embodiment of the blood purification device in the embodiment of the present application. The blood purification equipment includes: a slender tube 1, a power assembly 2, a dialyzer 3, an arterial line 4, a venous line 5 and a pressure sensor 6, the arterial line 4 is connected to the blood input end of the dialyzer 3, and the venous line 5 is connected to the blood output end of the dialyzer 3, the first end of the slender tube 1 is connected to the venous line 5, the second end of the slender tube 1 is connected to the power assembly 2, and the arterial line 4 outputs the patient's blood to The dialyzer 3 is used to hemodialyze the blood through the dialyzer 3. The venous line 5 returns the hemodialyzed blood to the veins of the human body. The power component 2 provides the driving force to make the elongated tube 1 connected to the Liquid, the pressure difference at both ends of the slender tube 1 can be controlled through the power assembly 2, so as to control the liquid flow rate and the liquid flow time in the slender tube 1; the pressure sensor 6 is arranged on the slender tube 1, and can be measured by the pressure sensor 6 The pressure of the liquid in the elongated tube 1 obtains pressure measurements.

The blood purification equipment also includes: a blood detector 7, which is used to detect whether there is blood in the venous line 5; Flow direction: heparin pump 9, used for injecting heparin; first liquid storage bag 10, used for storing filtrate; second liquid storage bag 11, used for storing dialysate; third liquid storage bag 12, used for storing replacement fluid The filter pump 13 is located between one end of the dialyzer 3 and the first liquid storage bag 10; the dialysate pump 14 is located between the other end of the dialyzer 3 and the second liquid storage bag 11; the replacement fluid pump 15 is located The front end of the third liquid storage bag 12; The venous pot 16 between the dialyzer 3 and the venous line 5, and the liquid level detector 17 on the venous pot 16; Pre-replacement 18 and post-replacement 19; a first heater 20 between the dialyzer 3 and the dialysate pump 14, a first cut-off detector 21 between the dialysate pump 14 and the second liquid storage bag 11; A leak detector 22 between the dialyzer 3 and the filtration pump 13; a second heater 23 between the post-displacement 19 and the replacement fluid pump 15, and between the replacement fluid pump 15 and the third fluid storage bag 12 The second cut-off detector 24; the bubble detector 25 located on the venous line 5.

In order to better illustrate the method of detecting blood viscosity by the blood purification equipment in the embodiment of the present application, the principle of liquid viscosity detection is described below:

Viscosity detection principle: According to Poisson's law of fluid mechanics:

Q＝ΔP×πR ⁴ /(8μL)

Wherein Q is the flow rate, the unit is m ³ /s, R is the radius of the slender tube 1, the unit is m, ΔP is the pressure drop at the inlet and outlet of the slender tube 1, the unit is Pa, L is the length of the slender tube 1, the unit is m, u is the dynamic viscosity, the unit is Pa.s.

Since the liquid is sucked into the slender tube 1, the damping produced by the liquid is close to u (viscosity) × t (the time for the power injector to suck the liquid), so the change factor at this time is only linear with the damping, that is, the change value of ΔP1 = ku × t, after conversion of this formula, it is obtained: u=ΔP1/k×t, wherein, ΔP1 represents the change amount of the liquid pressure in the slender tube 1, t represents the change time of the liquid pressure in the slender tube 1, and k represents the system parameter; ΔP1 Both k and t are values that can be obtained by measurement, and k is only related to the pipeline structure of the blood purification equipment itself.

Therefore, in this embodiment, in the preflushing stage, the value of k is first determined by using the flow state of the replacement fluid in the slender tube 1, and then in the blood treatment stage, using the flow state of the blood in the slender tube 1, it can be calculated Blood viscosity, so that the hemodynamic parameter-blood viscosity can be detected in real time during hemodialysis, which can be used as a reference for medical staff to evaluate the effect of hemodialysis, so as to further ensure the safety and efficiency of patients undergoing hemodialysis.

3 and 4, the blood purification device provided in the embodiment of the present application also includes: a processor 301 and a memory 303, the processor 301 is electrically connected to the memory 303 and the pressure sensor 6 through the bus 302, and the memory 303 stores information that can be The program instructions executed by the processor 301, the processor 301 calls the program instructions to perform the following methods:

Step S410 , output the replacement fluid to the arterial line 4 , the dialyzer 3 and the venous line 5 according to the priming start command output by the user, and output the replacement fluid to the elongated tube 1 through the power assembly 2 .

Before starting the blood purification equipment, it is necessary to install the tubes of the blood purification equipment, that is, to connect the pipelines of the blood purification equipment according to the structural diagram (such as shown in Figure 1), and to ensure that the different parts can be tightly connected without any Connecting gaps, such as connecting the first end of the arterial line 4 to the blood input end of the dialyzer 3, connecting the second end of the arterial line 4 to the patient's artery, etc., so as to ensure that the blood purification equipment is in normal physical condition. Connection Status.

After the blood purification equipment is installed, a pre-flush start instruction can be issued, and the processor is used to control the blood purification equipment to enter the pre-flush stage according to the pre-flush start instruction. The pre-flush stage is a necessary step in the operation of the blood purification equipment. After the pre-flushing stage, impurities remaining in the arterial line 4 , the dialyzer 3 and the venous line 5 can be prevented from affecting the subsequent blood treatment process. The priming stage will be described below in conjunction with FIG. 1. In the priming stage, one end of the arterial line 4 is connected to the third liquid storage bag 12, and the third liquid storage bag 12 is used to store the replacement fluid. The other end of the venous line 5 One end is connected to the waste liquid bag, one end of the arterial line 4 is connected to the replacement fluid, and the replacement liquid flows through the arterial line 4, the dialyzer 3 and the venous line 5 in order to flush the lines in the blood purification equipment, The flushed replacement fluid becomes waste liquid, which is stored in the waste liquid bag. When there is flowing replacement liquid in the venous line 5, the driving force is provided by the power assembly 2, so that the slender tube 1 flows from the venous line 5 Inhale the replacement fluid, even if the replacement fluid is output to the elongated tube 1 through the power assembly 2.

The elongated tube 1 in the present embodiment can be selected as the elongated tube with small holes. The diameter of the elongated tube with small holes is 1 mm and the length is 200 mm. The elongated tube with small holes can simulate the flow mode of blood in capillaries, so that Because the pressure sensor 6 can detect the pressure variation of the elongated tube 1 more accurately, and can avoid the phenomenon that the liquid in the venous line 5 is wasted.

Step S420 , calculating the change amount of the replacement fluid pressure of the elongated tube 1 and the change time of the replacement fluid pressure of the elongated tube 1 according to the pressure measurement data.

When the slender tube 1 is connected to the replacement fluid, the pressure of the replacement fluid in the slender tube 1 will gradually increase, for example: the change in the replacement fluid pressure of the slender tube 1 is 100mmHg (a positive value of the change in the pressure of the replacement fluid represents a slender The pressure of the replacement fluid in the tube 1 gradually increases, and the change in the pressure of the replacement fluid is negative, which means that the pressure of the replacement fluid in the slender tube 1 gradually decreases), and the pressure sensor 6 can measure the pressure of the replacement fluid in the slender tube 1 to obtain pressure measurement data , and calculate the displacement fluid pressure change amount of the elongated tube 1 and the displacement fluid pressure change time of the elongated tube 1 through the pressure measurement data.

Specifically, as an optional implementation, referring to FIG. 1, a pressure sensor 6 may be provided at the first end of the elongated tube 1, and the displacement fluid pressure variation of the elongated tube 1 may be calculated according to the pressure measurement data, including:

If the total amount of the replacement fluid connected to the slender tube 1 is greater than or equal to the preset volume, the pressure sensor 6 measures the replacement fluid pressure value of the slender tube 1, and according to the replacement fluid pressure value of the slender tube 1 and the slender tube 1 Calculate the pressure change of the replacement fluid in the slender tube 1 based on the pressure value without the replacement fluid.

Wherein, the preset volume is a value set in advance, and the preset volume is related to the diameter of the slender tube 1 and the length of the slender tube 1, and those skilled in the art can set it according to the actual situation, for example: the length of the slender tube 1 If the diameter is 1mm and the length of the slender tube 1 is 200mm, the preset volume can be 200uL. When it is detected that the total amount of replacement fluid connected to the slender tube 1 is greater than or equal to 200uL, the pressure sensor 6 is used to measure the volume of the slender tube. 1 displacement fluid pressure value.

Change in displacement fluid pressure = second pressure detection value - first pressure detection value, wherein the first pressure detection value represents the displacement hydraulic pressure of the elongated tube 1 measured by the pressure sensor 6 when the elongated tube 1 is not connected to the replacement fluid Force value; the second pressure detection value represents the replacement fluid pressure value of the elongated tube 1 measured by the pressure sensor 6 when the total amount of the replacement fluid inserted into the elongated tube 1 is greater than or equal to a preset volume. For example: when the slender tube 1 is not connected to the replacement fluid, the pressure of the replacement fluid in the slender tube 1 measured by the pressure sensor 6 is 10mmHg. When the replacement fluid is output to the slender tube 1 through the power assembly 2, the slender tube 1 When the total amount of replacement fluid introduced is greater than or equal to 200uL, the pressure of the replacement fluid in the elongated tube 1 measured by the pressure sensor 6 is 100mmHg, and the variation of the replacement fluid pressure is 100mmHg-10mmHg=90mmHg.

As another optional implementation, referring to Fig. 2, the pressure sensor 6 may also include a first pressure sensor and a second pressure sensor, the first pressure sensor is located at the first end of the elongated tube 1, and the second pressure sensor is located at the The second end of the long tube 1 calculates the displacement fluid pressure variation of the slender tube 1 according to the pressure measurement data, including:

After the slender tube 1 is connected to the replacement fluid, the pressure value of the replacement fluid at the first end of the slender tube 1 is detected by the first pressure sensor to obtain the first pressure detection value, and the second pressure of the slender tube 1 is detected by the second pressure sensor. The pressure value of the displacement fluid at the end is obtained to obtain the second pressure detection value, and the change in the displacement fluid pressure of the elongated tube 1 is calculated according to the difference between the first pressure detection value and the second pressure detection value.

Among them, the first pressure detection value represents the pressure of the replacement fluid connected to the slender tube 1 from the venous line 5, and the second pressure detection value represents the pressure of the power assembly 2 sucking the replacement fluid from the slender tube 1. According to the first pressure detection value The difference between the pressure and the second pressure detection value can be used to obtain the change in pressure of the replacement fluid in the elongated tube 1, thereby facilitating the subsequent calculation of the viscosity system parameters of the blood purification device and the first blood viscosity of the patient's blood.

There is a one-to-one correspondence between the change time of the displacement fluid pressure of the slender tube 1 and the change amount of the displacement fluid pressure of the slender tube 1, and the change time of the displacement fluid pressure of the slender tube 1 represents the occurrence The time period of change, for example: the displacement fluid pressure of the elongated tube 1 changes by 100mmHg, then the displacement fluid pressure change time of the elongated tube 1 refers to the corresponding time when the displacement fluid pressure of the elongated tube 1 changes by 100mmHg.

Specifically, as an optional implementation, calculating the change time of the displacement fluid pressure of the elongated tube 1 according to the pressure measurement data includes:

If the total amount of the replacement fluid inserted into the slender tube 1 is greater than or equal to the preset volume, the time point when the slender tube 1 is not connected with the replacement fluid is taken as the starting point of time, and the replacement fluid inserted into the slender tube 1 The time point at which the total amount is greater than or equal to the preset volume is taken as the time cut-off point, and the change time of the replacement fluid pressure of the elongated tube 1 = time cut-off point - time start point.

Step S430 : Determine the parameters of the viscosity system according to the preset viscosity of the replacement fluid, the amount of change in pressure of the replacement fluid in the elongated tube 1 , and the change time of the pressure of the replacement fluid in the elongated tube 1 .

Under normal circumstances, the replacement fluid is water for injection, and the viscosity of water is usually a fixed value, and there is no concentration problem in water. Those skilled in the art can refer to relevant technical documents to determine the viscosity of water, and approximate fitting by the viscosity of water The preset viscosity of the replacement fluid, for example: the viscosity of water is 100Pa.S, and the preset viscosity of the replacement fluid is 100Pa.S.

To determine the preset viscosity of the replacement fluid, the amount of change in pressure of the replacement fluid in the elongated tube 1, and the change time of the pressure of the replacement fluid in the elongated tube 1, the viscosity system parameters can be calculated by the following formula:

Viscosity system parameter k=variation of displacement fluid pressure/(preset viscosity of displacement fluid×change time of displacement fluid pressure).

Step S440 , according to the blood therapy instruction output by the user, the blood is dialyzed through the dialyzer 3 , and the dialyzed blood is output to the elongated tube 1 through the power assembly 2 .

After the blood purification device has passed the pre-flushing stage, the processor will control the blood purification device to enter the blood treatment stage, and when the user outputs a blood therapy instruction, control the blood purification device to enter the blood therapy stage according to the blood therapy instruction. In the blood treatment stage, one end of the arterial line 4 is connected to blood, and the blood flows through the arterial line 4, the dialyzer 3 and the venous line 5 in sequence, and the dialyzer 3 is controlled to perform hemodialysis on the blood, and the blood passes through the venous line 5 The blood after hemodialysis is returned to the vein of the patient. When there is blood flowing in the venous line 5, the driving force is provided by the power assembly 2, so that the elongated tube 1 sucks blood from the venous line 5, that is, through the power The assembly 2 allows access of the elongated tube 1 to the blood.

Step S450, calculating the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 according to the pressure measurement data.

When the slender tube 1 is connected to the blood, the blood pressure of the slender tube 1 will gradually increase, for example: the blood pressure change of the slender tube 1 is 100mmHg (a positive value of the blood pressure change represents the blood pressure of the slender tube 1 The pressure gradually increases, and the blood pressure variation is a negative value representing that the blood pressure of the slender tube 1 gradually decreases), the pressure sensor 6 can measure the blood pressure of the slender tube 1, obtain the pressure measurement data, and calculate the slender tube 1 through the pressure measurement data. The first blood pressure change amount of the long tube 1 and the first blood pressure change time of the elongated tube 1 .

Specifically, as an optional implementation manner, referring to FIG. 1 , a pressure sensor 6 can be provided at the first end of the elongated tube 1, and the first blood pressure variation of the elongated tube 1 can be calculated according to the pressure measurement data, including:

If the total amount of blood inserted into the slender tube 1 is greater than or equal to the preset volume, the blood pressure value of the slender tube 1 is measured by the pressure sensor 6. Calculate the first blood pressure variation in the elongated tube 1 according to the pressure value of the blood entering the blood.

Wherein, the preset volume is a value set in advance, and the preset volume is related to the diameter of the slender tube 1 and the length of the slender tube 1, and those skilled in the art can set it according to the actual situation, for example: the length of the slender tube 1 If the diameter is 1mm and the length of the slender tube 1 is 200mm, the preset volume can be 200uL. When it is detected that the total amount of blood inserted into the slender tube 1 is greater than or equal to 200uL, the pressure sensor 6 is used to measure the amount of blood in the slender tube 1. blood pressure value.

First blood pressure variation=fourth pressure detection value−third pressure detection value, wherein the third pressure detection value represents the blood pressure of the elongated tube 1 measured by the pressure sensor 6 when the elongated tube 1 is not connected to blood value; the fourth pressure detection value represents the blood pressure value of the elongated tube 1 measured by the pressure sensor 6 when the total amount of blood inserted into the elongated tube 1 is greater than or equal to the preset volume.

As another optional implementation, referring to Fig. 2, the pressure sensor 6 may also include a first pressure sensor and a second pressure sensor, the first pressure sensor is located at the first end of the elongated tube 1, and the second pressure sensor is located at the The second end of the long tube 1 calculates the first blood pressure variation of the slender tube 1 according to the pressure measurement data, including:

After the slender tube 1 is connected to the blood, the blood pressure value at the first end of the slender tube 1 is detected by the first pressure sensor to obtain a third pressure detection value, and the blood at the second end of the slender tube 1 is detected by the second pressure sensor The pressure value is to obtain a fourth pressure detection value, and calculate the first blood pressure change amount of the elongated tube 1 according to the difference between the third pressure detection value and the fourth pressure detection value.

Wherein, the third pressure detection value represents the blood pressure connected by the slender tube 1 from the venous line 5, and the fourth pressure detection value represents the pressure of the power component 2 sucking blood from the slender tube 1, according to the third pressure detection value and the first The difference between the four pressure detection values can obtain the first blood pressure change amount of the elongated tube 1 , so as to facilitate subsequent calculation of the first blood viscosity of the patient's blood.

There is a one-to-one correspondence between the first blood pressure change time of the slender tube 1 and the first blood pressure change amount of the slender tube 1, and the first blood pressure change time of the slender tube 1 represents the first blood pressure change time of the slender tube 1. A period of time during which changes in blood pressure occur.

Specifically, as an optional implementation, calculating the first blood pressure change time of the elongated tube 1 according to the pressure measurement data includes:

If the total amount of blood inserted into the slender tube 1 is greater than or equal to the preset volume, the time point when the slender tube 1 is not connected with blood is used as the starting point of time, and the total amount of blood inserted into the slender tube 1 The time point greater than or equal to the preset volume is taken as the time cut-off point, and the blood pressure change time of the elongated tube 1 = time cut-off point - time start point.

Step S460 : Determine the first blood viscosity according to the viscosity system parameters, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 .

To determine the viscosity system parameter k, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1, the first blood viscosity can be calculated by the following formula:

First blood viscosity=first blood pressure change amount/(viscosity system parameter k×first blood pressure change time).

The first blood pressure change amount, the viscosity system parameter k and the first blood pressure change time are all known quantities, and the first blood viscosity can be calculated according to the above formula. In this embodiment, the first blood viscosity can be obtained during the blood treatment stage, and the patient's hemodialysis status can be monitored according to the first blood viscosity.

The blood purification equipment provided in the embodiment of the present application uses the operation steps in the hemodialysis process to obtain the necessary viscosity system parameters in the viscosity detection process in advance in the preflushing stage, so as to provide a data basis for the later calculation process of blood viscosity. When the patient is undergoing hemodialysis, it is convenient to accurately calculate the blood viscosity of the patient. The embodiment of the present application perfectly combines the blood viscosity detection with the hemodialysis process, and effectively integrates the viscosity detection into the hemodialysis process. Detecting and monitoring the patient's blood viscosity has strong practicality and convenience; in addition, in the embodiment of the present application, the method of determining the blood viscosity by cleverly using the pressure change with time when the fluid medium is inhaled can effectively obtain blood Viscosity value, low detection cost, high detection feasibility, high detection reliability, and can detect blood viscosity in real time during hemodialysis, so that medical staff can refer to the evaluation process of hemodialysis effect according to blood viscosity, avoiding patients Cardiovascular and other related complications occur, thereby further ensuring the safety of patients undergoing hemodialysis, and overcoming the problem in the prior art that the patient's blood viscosity cannot be detected during hemodialysis, resulting in low safety of patients' hemodialysis treatment.

On the basis of the above-mentioned embodiments, the blood purification device further includes a display screen 26. In step S460, according to the viscosity system parameters, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1, After determining the first blood viscosity, it also includes:

The processor is also used to display the change curve of the first blood viscosity with time through the display screen 26 .

Among them, the first blood viscosity is not a fixed value, but in the blood treatment stage, according to the value obtained by real-time detection and calculation, in the blood treatment stage, the first blood viscosity obtained at different times will also change, so that the first blood viscosity can be plotted A time-varying curve of blood viscosity. According to the first blood viscosity-varying curve with time, the user can judge the hemodialysis treatment effect of the patient.

Figure 5 is the change curve of the first blood viscosity with time, combined with what is shown in Figure 5, in general, the first blood viscosity gradually increases with time, and the user can get The patient's hemodialysis treatment effect, and the fluctuation state of the hemodialysis treatment can be obtained according to the change curve of the first blood viscosity with time, so as to ensure the safety of the patient's hemodialysis treatment. For example, when the change curve of the first blood viscosity with time turns into a horizontal line, it indicates that the blood treatment stage is in a fault state, and the user can timely process the dialyzer according to the change curve of the first blood viscosity with time displayed on the display screen 26. 3 fault status, thereby ensuring the safety of the patient's hemodialysis treatment.

It should be noted that the treatment effect of hemodialysis includes multiple indicators such as the amount of dehydration of the dialyzer, the clearance rate of urea in the blood by the dialyzer, and those skilled in the art can judge these according to the change curve of the first blood viscosity with time. Whether the indicator is normal.

On the basis of the above-mentioned embodiments, in step S440, according to the blood treatment instruction output by the user, the blood is dialyzed through the dialyzer 3, and before the dialyzed blood is output to the elongated tube 1 through the power assembly 2, the processor is also used to implement:

It is judged whether the time when the arterial line 4 is connected to the replacement fluid is longer than the preset pre-flush time, and if the time when the arterial line 4 is connected to the replacement fluid is longer than the preset pre-flush time, then a blood drainage start command is issued.

The control process of the blood purification equipment can be followed in sequence: the preflushing stage, the blood introduction stage and the blood treatment stage. When the time for the arterial line 4 to be connected to the replacement fluid is greater than the preset preflushing time, it means that the blood purification equipment has completed the preflushing stage, the blood purification device can be controlled to enter the blood-drawing stage through the blood-drawing start command. Wherein, the preset pre-flush time represents the maximum time for the blood purification equipment to pre-flush, and the preset pre-flush time can be set by those skilled in the art based on clinical experience. For example, in the hemodialysis mode, the preset pre-flush time is usually 5min to 8min.

On the basis of the above-mentioned embodiments, the blood purification equipment also includes a blood detector 7, which is arranged on the venous line 5, specifically, the first end of the venous line 5 is connected to the blood output end of the dialyzer 3 , the second end of the venous line 5 is connected to the vein of the patient, the first end of the elongated tube 1 is connected to the connection point of the venous line 5, and the blood detector 7 is located at the connection point of the venous line 5 and the connection point of the venous line 5. On the pipeline between the second ends, the blood detector 7 is used to detect whether there is blood in the venous pipeline 5, and the processor is also used to perform:

According to the blood extraction start command output by the user, the blood is output to the arterial line 4, the dialyzer 3 and the venous line 5, and when the blood detector 7 detects that there is blood in the venous line 5, the blood is output through the power assembly 2 to the elongated tube 1.

In the blood extraction stage, the blood is inserted through the arterial line 4, and the blood flows through the arterial line 4, the dialyzer 3, and the venous line 5 in turn, and the blood detector 7 uses the principle of light sensitivity to detect whether there is blood in the venous line 5 , when the blood detector 7 detects that there is blood in the venous line 5, the control power assembly 2 provides driving force to make the slender tube 1 suck blood from the venous line 5, even if the blood is output to the slender tube through the power assembly 2 Tube 1.

The second blood pressure change amount of the elongated tube 1 and the second blood pressure change time of the elongated tube 1 are calculated according to the pressure measurement data.

When the slender tube 1 is connected to the blood, the blood pressure of the slender tube 1 will gradually increase. The pressure sensor 6 can measure the blood pressure of the slender tube 1 to obtain pressure measurement data, and calculate the pressure of the slender tube 1 through the pressure measurement data. The second blood pressure change amount of the elongated tube 1 and the second blood pressure change time of the slender tube 1, wherein the second blood pressure change amount of the slender tube 1 and the second blood pressure change time of the slender tube 1 are calculated by the pressure measurement data The method is the same as the method of calculating the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 through the pressure measurement data, and will not be repeated here.

The second blood viscosity is determined according to the viscosity system parameters, the second blood pressure change amount of the elongated tube 1 and the second blood pressure change time of the elongated tube 1 .

After determining the viscosity system parameter k, the second blood pressure change amount of the slender tube 1 and the second blood pressure change time of the slender tube 1, the second blood viscosity can be calculated by the following formula:

Second blood viscosity=second blood pressure variation/(viscosity system parameter k×second blood pressure variation time).

It should be noted that the first blood viscosity and the second blood viscosity have completely different physiological reference values. The first blood viscosity is the blood viscosity of the patient detected in the blood treatment stage, representing the blood viscosity of the blood treatment stage; the second blood viscosity is the patient's blood viscosity detected in the blood drainage stage, representing the blood viscosity of the patient before hemodialysis. When a patient undergoes hemodialysis treatment, the patient's blood viscosity is usually relatively low during the blood drainage phase (because there will be more water in the patient's blood at this time); during the blood treatment phase, the patient's blood viscosity is usually relatively high (Because the patient's blood will remove excess water in the blood after hemodialysis), according to the first blood viscosity and the second blood viscosity, the dehydration effect of the dialyzer can be judged.

On the basis of the foregoing embodiments, the processor is also configured to execute:

According to the difference between the first blood viscosity and the second blood viscosity, the dehydration effect of the dialyzer 3 is judged.

Wherein, the first blood viscosity represents the blood viscosity in the blood treatment stage, and the second blood viscosity represents the blood viscosity before hemodialysis. The difference between the first blood viscosity and the second blood viscosity represents the change in the blood viscosity of the patient after hemodialysis, and the greater the difference between the first blood viscosity and the second blood viscosity, it means that the patient has undergone hemodialysis The greater the amount of dehydration after the end, the smaller the difference between the first blood viscosity and the second blood viscosity, it means that the dehydration amount of the patient after hemodialysis is smaller, and the patient passes through the dialyzer 3 pairs during hemodialysis. The blood is dehydrated. Under normal circumstances, with the increase of hemodialysis treatment time, the patient's blood viscosity will gradually increase, so the first blood viscosity will increase with the increase of hemodialysis treatment time. When the first blood viscosity and The greater the difference between the second blood viscosity, the better the dehydration effect of the dialyzer 3, and the greater the actual dehydration amount of the patient's blood; when both the first blood viscosity and the second blood viscosity The smaller the difference, the worse the dehydration effect of the dialyzer 3, and the smaller the actual dehydration amount of the patient's blood. According to the difference between the first blood viscosity and the second blood viscosity, directly To judge the dehydration effect of the dialyzer 3, there is no need to calculate the actual dehydration amount of the patient's blood before judging the dehydration effect of the dialyzer 3, which simplifies the steps of judging the dehydration effect of the dialyzer 3, which is conducive to improving the accuracy of judgment, and this The method for judging the dehydration effect of the dialyzer 3 in the embodiment is scientific and reasonable.

On the basis of the foregoing embodiments, according to the difference between the first blood viscosity and the second blood viscosity, the dehydration effect of the dialyzer 3 can be judged, specifically the following method can be adopted:

If it is judged that the difference between the first blood viscosity and the second blood viscosity satisfies the first preset condition, the dehydration effect of the dialyzer 3 is poor, and a first prompt is issued;

If it is judged that the difference between the first blood viscosity and the second blood viscosity satisfies the second preset condition, the dehydration effect of the dialyzer 3 is good, and a second prompt is issued;

If it is judged that the difference between the first blood viscosity and the second blood viscosity satisfies the third preset condition, the dehydration effect of the dialyzer 3 is good, and a third prompt is issued;

Wherein, the first preset condition is: |first blood viscosity-second blood viscosity|≤first preset difference;

The second preset condition is: first preset difference<|first blood viscosity-second blood viscosity|≤second preset difference;

The third preset condition is: second preset difference<|first blood viscosity−second blood viscosity|.

Wherein, the first preset difference and the second preset difference are values set in advance, which can be set by those skilled in the art based on clinical experience, which is not further limited in the embodiments of the present application, for example : The first preset difference is 10Pa.S, and the second preset difference is 30Pa.S.

In this embodiment, according to the relationship between the first blood viscosity and the second blood viscosity and the first preset difference and the second preset difference, the dehydration effect of the dialyzer 3 is divided into three levels, poor, average, good , and different dehydration effects give different prompts, so that the actual dehydration effect of the dialyzer 3 can be clearly understood. Wherein, the first prompt, the second prompt and the third prompt can be prompted by different light sources, and can also be prompted by different sounds, for example: the first prompt can be a red light, the second prompt can be a blue light, and the third prompt can be a green light , when the user sees light sources of different colors, the actual dehydration effect of the dialyzer 3 can be known according to the different light sources, so that the actual hemodialysis status of the patient can be directly known.

On the basis of the above embodiments, after determining the second blood viscosity according to the viscosity system parameters, the second blood pressure change amount of the elongated tube 1 and the second blood pressure change time of the elongated tube 1, it also includes:

The target dehydration amount of the dialyzer 3 is determined according to the second blood viscosity, and the processor is also used to display the target dehydration amount of the dialyzer 3 through the display screen 26 .

Wherein, the second blood viscosity represents the water content in the patient's blood before hemodialysis, for example: the second blood viscosity is 50 Pa.S, and the target dehydration amount of the dialyzer 3 represents the moisture that the patient removes from the patient's blood during the blood treatment stage a specific total amount. There is a negative correlation between the second blood viscosity and the target dehydration amount, that is, when the second blood viscosity is higher, it means that the water content in the patient's blood is not high, and the patient's blood is dehydrated. When the target dehydration amount is low; when the viscosity of the second blood is low, it means that the water content in the patient's blood is high, and the target water content is high when the patient's blood is dehydrated. There is also a one-to-one correspondence between the second blood viscosity and the target dehydration amount. The relationship diagram between the second blood viscosity and the target dehydration amount is shown in Figure 6. Figure 6 is based on clinical experience of those skilled in the art The obtained correspondence graph between the second blood viscosity and the target dehydration amount is summarized. After the second blood viscosity is determined, according to the graph corresponding to FIG. 6 , the corresponding target dehydration amount under the second blood viscosity can be determined. Thus, in the stage of blood treatment, when the dialyzer 3 dialyzes the blood, the actual dehydration volume of the dialyzer 3 can be detected, and when the actual dehydration volume of the dialyzer 3 is equal to the target dehydration volume, the dialyzer 3 can be controlled to stop blood flow. Dialysis, so that the patient can achieve the best hemodialysis treatment effect. In this embodiment, according to the second blood viscosity, the target dehydration amount of the dialyzer 3 is scientifically and reasonably determined, so that the dialyzer 3 can be controlled at a later stage to stop the blood at an appropriate time. Dialysis process, so as to ensure better hemodialysis treatment effect.

In this embodiment, the dehydration effect of the dialyzer can be judged according to the difference between the blood viscosity of the patient in the blood drawing stage and the blood viscosity in the blood treatment stage, and an effective and scientific reference index can be provided for the medical staff, so that the medical staff It can directly judge whether the patient is in a normal dehydration state during hemodialysis according to the difference between the first blood viscosity and the second blood viscosity, which is conducive to improving the accuracy of judgment, thereby preventing the water loss of the dialyzer during hemodialysis Too much or too much fluid replacement will lead to problems such as low blood concentration and blood cell shape deformation, which can effectively prevent cardiovascular-related complications caused by hemodialysis and improve the safety of patients in the blood treatment process.

On the basis of the above embodiments, the blood purification device also includes: a first temperature sensor and a second temperature sensor (not shown in the figure), the first temperature sensor is used to detect the blood temperature in the arterial pipeline 4, and obtain the second First detect the temperature, the second temperature sensor is used to detect the blood temperature in the venous line 5 to obtain the second detected temperature, and the processor is also used to execute:

Judging whether the absolute value of the difference between the first detected temperature and the second detected temperature is less than the preset temperature difference, if the absolute value of the difference between the first detected temperature and the second detected temperature is smaller than the preset temperature difference , then the first blood viscosity is determined according to the viscosity system parameters, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 .

Wherein, the first detection temperature represents the temperature of blood directly drawn from the patient, the second detection temperature represents the blood temperature after hemodialysis, and the difference between the first detection temperature and the second detection temperature represents the blood of the patient after hemodialysis The resulting temperature change. The preset temperature difference represents the allowable temperature change error of the patient's blood during the hemodialysis process. In the embodiments of the present application, the specific value of the preset temperature difference is not further limited. Those skilled in the art can according to the clinical treatment Set by experience, for example: the preset temperature difference is 2°C.

When the patient's hemodialysis process is in a normal state, the difference between the first detected temperature and the second detected temperature will not be too large, that is, the absolute value of the difference between the first detected temperature and the second detected temperature is less than the preset temperature In the normal hemodialysis state, the first blood viscosity can be calculated according to the viscosity system parameters, the first blood pressure change amount of the slender tube and the first blood pressure change time of the slender tube, so that the first blood viscosity can be calculated according to the first Blood viscosity monitors a patient's hemodialysis status. However, when the patient's hemodialysis process is in an abnormal state, the difference between the first detected temperature and the second detected temperature is relatively large, that is, the absolute value of the difference between the first detected temperature and the second detected temperature is greater than or equal to the preset temperature This indicates that the temperature of the patient's blood during dialysis has malfunctioned. These failures may be due to the rupture of the dialyzer, blockage of the blood flowing in the dialyzer, etc., resulting in abnormal temperature. There is no real point in recalculating the first blood viscosity when the process temperature fails. Therefore, in the blood treatment stage of this embodiment, the first detection temperature and the second detection temperature can be detected in real time, and it can be judged whether there is a fault in the temperature during the hemodialysis process, and the difference between the first detection temperature and the second detection temperature When the absolute value of the difference between them is less than the preset temperature difference, the first blood viscosity is calculated, and the hemodialysis status of the patient is monitored according to the first blood viscosity.

Exemplarily, if the first detection temperature is 36°C, the second detection temperature is 35°C, the preset temperature difference is 2°C, and the absolute value of the difference between the first detection temperature and the second detection temperature is 1°C , which is less than the preset temperature difference, the patient’s hemodialysis process is in a normal state, and can be calculated according to the viscosity system parameters, the first blood pressure change amount of the slender tube 1 and the first blood pressure change time of the slender tube 1 The first blood viscosity is obtained, so that the patient's hemodialysis status can be monitored according to the first blood viscosity. If the first detection temperature is 38°C, the second detection temperature is 34°C, and the preset temperature difference is 2°C, the absolute value of the difference between the first detection temperature and the second detection temperature is 4°C, which is greater than the preset temperature. If the temperature difference is set, the patient's hemodialysis process is in an abnormal state, and there is no need to calculate the first blood viscosity at this time.

On the basis of the above embodiments, after determining the first blood viscosity in step S460 according to the viscosity system parameters, the first blood pressure change amount of the slender tube 1 and the first blood pressure change time of the slender tube 1, the processor Also used to execute:

The power assembly 2 is controlled to return all the residual blood in the power assembly 2 and the blood remaining in the elongated tube 1 to the venous line 5 through the elongated tube 1 .

In order to ensure real-time monitoring of the patient's hemodialysis status, the patient's first blood viscosity is periodically detected and calculated during the blood treatment phase. When the first blood viscosity is determined each time, the driving force needs to be provided by the power component 2 , so that the slender tube 1 sucks blood from the venous line 5, and both the power unit 2 and the slender tube 1 will store blood. This part of blood will not only lead to waste of blood, but also affect the subsequent first blood. Viscosity accuracy, therefore, after each determination of the first blood viscosity, all residual blood needs to be returned to the venous line 5, so as to ensure that when the blood viscosity of the patient is detected in real time during the blood treatment stage, not only can avoid The waste of blood in the venous line 5 reduces the blood viscosity detection cost of the patient and improves the accuracy and reliability of the blood viscosity detection.

The power assembly 2 of this embodiment may include a syringe and a drive assembly, the drive assembly is used to provide driving force for the syringe, and the syringe is used to access and store liquid. In the stage of blood treatment, when the patient’s first blood viscosity is detected each time, the movement of the syringe is controlled by the drive assembly, and the syringe is connected to the blood in the venous line 5 through the slender tube 1, and the slender tube 1 connects the venous The blood in the pipeline 5 is transported to the syringe for storage. When the elongated tube 1 transmits the blood, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 are calculated according to the pressure measurement data. , so as to calculate the first blood viscosity; when the first blood viscosity of the patient is detected and calculated each time, there will be residual blood in both the syringe and the elongated tube 1, in order to avoid the first blood viscosity of the patient being detected Blood waste occurs at the first blood viscosity and affects the accuracy of the subsequent first blood viscosity detection. In this embodiment, after each detection of the first blood viscosity, the residual blood in both the syringe and the elongated tube 1 is collected. All the blood is returned to the venous line 5, and the residual blood is returned to the patient's vein through the venous line 5, thereby solving the problem of blood waste during each calculation of the first blood viscosity and affecting the subsequent first blood viscosity. The problem of the accuracy of blood viscosity detection. Of course, the power assembly 2 in the embodiment of the present application may also be other devices, as long as the above functions are realized. The specific composition of the drive assembly is not further limited in the embodiments of the present application, and those skilled in the art can set it according to actual conditions.

On the basis of the above-mentioned embodiment, after determining the first blood viscosity according to the viscosity system parameters, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 in step S460, the processor further for executing:

Detect whether the coagulation phenomenon occurs in the blood in the venous line 5, and if the coagulation phenomenon occurs in the blood in the venous line 5, a fault prompt operation is issued.

Wherein, the coagulation phenomenon refers to: the contact between the blood and the wall of the venous line 5 triggers the coagulation mechanism of the blood, thus causing the coagulation of the blood in the venous line 5 . Since the blood in the venous line 5 needs to be drawn out through the elongated tube 1 when detecting the patient's first blood viscosity during the blood treatment stage, this will cause the blood flow in the venous line 5 to decrease, so the blood flow in the venous line 5 will be reduced. The blood in the blood is more prone to coagulation. In order to ensure the safety of the patient's hemodialysis treatment, it is necessary to detect whether the blood in the venous line has coagulation.

In this embodiment, when determining the first blood viscosity, at the same time, it is detected whether the blood in the venous line 5 coagulates. The coagulation phenomenon of the venous line 5 is dealt with in time, so as to prevent the coagulation phenomenon of the venous line 5 from endangering the safety of the patient's hemodialysis treatment.

It should be noted that the fault prompt operation in this embodiment belongs to the acousto-optic signal. If the blood coagulation phenomenon occurs in the venous line, the sound prompt operation can be issued, or the text prompt operation can be displayed on the display screen 26, so as to achieve fault alarm. Effect.

On the basis of the above-mentioned embodiments, in step S410, according to the pre-flushing start command output by the user, the replacement fluid is output to the arterial line 4, the dialyzer 3 and the venous line 5, and output to the slender tube 1 through the power assembly 2 Previously, the processor was also used to execute:

Detect the replacement fluid flow in the venous line 5, and determine whether the replacement fluid flow in the venous line 5 is greater than or equal to the preset replacement fluid flow rate, if the replacement fluid flow rate in the venous line 5 is greater than or equal to the preset replacement fluid flow rate , the replacement fluid is output to the elongated tube 1 through the power assembly 2 .

In the preflushing stage, the replacement fluid will flow through the arterial line 4, the dialyzer 3 and the venous line 5 in sequence, and the preflushing stage is mainly to detect the viscosity system parameters of the blood purification equipment, in order to improve the detection of the viscosity system parameters Accuracy, by increasing the flow rate of the replacement fluid in the venous line 5, the viscosity system parameters detected under the flow rate of the replacement fluid in the venous line 5 can have higher accuracy. When the flow rate of the replacement fluid in the venous line 5 is greater than or equal to the preset flow rate of the replacement fluid, the detected change in the pressure of the replacement fluid in the elongated tube 1 can truly reflect the viscosity of the replacement fluid, thereby obtaining a more accurate viscosity system parameters, but when the replacement fluid flow rate in the venous line 5 is less than the preset replacement fluid flow rate, it means that the replacement fluid flow rate in the venous line 5 is too small. In this case, the detected viscosity system parameters will be affected by the replacement fluid flow rate. Interference, resulting in a large detection error in the first blood viscosity of the patient in the blood treatment phase. In this embodiment, by limiting the relationship between the flow rate of the replacement fluid in the venous line 5 in the pre-flushing stage and the flow rate of the preset replacement fluid, errors in the parameters of the viscosity system caused by changes in the flow rate of the replacement fluid can be eliminated, thereby improving the performance of the first step in this embodiment. 1. Accuracy of blood viscosity detection.

On the basis of the above-mentioned embodiments, after calculating the change in pressure of the replacement fluid in the elongated tube 1 and the change time of the pressure of the replacement fluid in the elongated tube 1 according to the pressure measurement data in step S420, and in step S430 according to the preset pressure of the replacement fluid Viscosity, the displacement fluid pressure change amount of the slender tube 1 and the displacement fluid pressure change time of the slender tube 1, before determining the viscosity system parameters, the processor is also used to execute:

Detect whether there are bubbles in the replacement fluid in the venous line 5, and if there are bubbles in the replacement fluid in the venous line 5, then calibrate the change in pressure of the replacement fluid in the elongated tube 1, and perform a calibration according to the preset viscosity, Viscosity system parameters are determined by the calibrated displacement fluid pressure change amount of the elongated tube 1 and the displacement fluid pressure change time of the elongated tube 1 .

If there are no air bubbles in the replacement fluid in the venous line 5, it is not necessary to calibrate the change in pressure of the replacement fluid in the slender tube 1, and it can be directly based on the preset viscosity of the replacement fluid and the change in pressure of the replacement fluid in the slender tube 1. and the displacement fluid pressure change time of the slender tube 1 to determine the viscosity system parameters.

Among them, in the pre-flushing stage, during the process of sequentially flushing the arterial line 4, dialyzer 3, and venous line 5 with the replacement fluid, the replacement fluid in the venous line 5 may contain some air bubbles. When detecting the change in pressure of the replacement fluid in the elongated tube 1 , air bubbles in the replacement fluid will affect the pressure detection accuracy of the pressure sensor 6 . In order to eliminate the interference of air bubbles on the pressure variation of the replacement fluid in the slender tube 1, in this embodiment, it is first detected whether there are bubbles in the replacement fluid in the venous line 5, and if it is detected that there are bubbles in the replacement fluid in the venous line 5, Then the displacement fluid pressure variation of the slender tube 1 is calibrated, and the calibrated displacement fluid pressure variation of the slender tube 1 may increase or decrease, but according to the calibrated displacement fluid pressure variation of the slender tube 1 The parameters of the viscosity system can be calculated more accurately, so that the patient's first blood viscosity can be accurately calculated later, so as to improve the detection accuracy of the first blood viscosity in the embodiment of the present application.

In this embodiment, a bubble detector 25 may be provided on the venous line 5 to detect whether there are bubbles in the replacement fluid in the venous line 5 . In this embodiment, the method for detecting whether there are bubbles in the replacement fluid in the venous line 5 is not further limited, and those skilled in the art can choose according to the actual situation. Ultrasonic testing is performed on the replacement fluid in the replacement fluid, and the amount of air bubbles in the replacement fluid is converted from non-electricity to electrical signals. For example, the amount of air bubbles in the replacement fluid is converted from non-electricity to voltage signals. Whether there are air bubbles in the replacement fluid in the venous line 5 can be identified based on the degree of difference between them.

Those skilled in the art can set a fixed pressure calibration value based on clinical experience, and calibrate the displacement fluid pressure variation of the slender tube 1 according to the pressure calibration value. For example, if the pressure calibration value is -10mmHg, the calibrated slender Change in pressure of replacement fluid in tube 1 = change in pressure of replacement fluid in slender tube 1-10mmHg; those skilled in the art can also set the value between the volume of bubbles in the replacement fluid in venous line 5 and the pressure calibration value based on clinical experience. According to the corresponding curve, by detecting the bubble volume of the replacement fluid in the venous line 5, and finding the corresponding pressure calibration value through the corresponding curve, according to the pressure change of the replacement fluid in the slender tube 1 and the pressure calibration value, the calibrated slender tube 1 is obtained. Change in displacement fluid pressure in tube 1. Of course, those skilled in the art can also calibrate the variation of the replacement fluid pressure of the elongated tube 1 according to traditional intelligent algorithms (such as genetic algorithms). In this embodiment, the variation of the displacement fluid pressure of the elongated tube 1 is calibrated The method is not further limited, those skilled in the art can choose according to the actual situation.

In an optional embodiment, a blood purification device is provided. As shown in FIG. 3 , the blood purification device 300 shown in FIG. 3 includes: a processor 301 and a memory 303 . Wherein, the processor 301 is connected to the memory 303 , such as through a bus 302 . Optionally, the blood purification device 300 may further include a transceiver 304 . It should be noted that, in practical applications, the transceiver 304 is not limited to one, and the structure of the electronic device 300 does not limit the embodiment of the present application.

The processor 301 can be a CPU (Central Processing Unit, central processing unit), a general-purpose processor, a DSP (Digital Signal Processor, a data signal processor), an ASIC (Application Specific Integrated Circuit, an application specific integrated circuit), an FPGA (Field Programmable Gate Array, field programmable gate array) or other programmable logic devices, transistor logic devices, hardware components, or any combination thereof. It can implement or execute the various illustrative logical blocks, modules and circuits described in connection with the present disclosure. The processor 301 may also be a combination that implements computing functions, for example, a combination of one or more microprocessors, a combination of a DSP and a microprocessor, and the like.

Bus 302 may include a path for communicating information between the components described above. The bus 302 may be a PCI (Peripheral Component Interconnect, Peripheral Component Interconnect Standard) bus or an EISA (Extended Industry Standard Architecture, Extended Industry Standard Architecture) bus or the like. The bus 302 can be divided into address bus, data bus, control bus and so on. For ease of representation, only one thick line is used in FIG. 3 , but it does not mean that there is only one bus or one type of bus.

Memory 303 can be ROM (Read Only Memory, read-only memory) or other types of static storage devices that can store static information and instructions, RAM (Random Access Memory, random access memory) or other types of memory that can store information and instructions A dynamic storage device can also be EEPROM (Electrically Erasable Programmable Read Only Memory, Electrically Erasable Programmable Read-Only Memory), CD-ROM (Compact DiscRead Only Memory, CD-ROM) or other CD storage, CD storage (including compact CD, laser discs, compact discs, digital versatile discs, blu-ray discs, etc.), magnetic disk storage media or other magnetic storage devices, or any other medium capable of carrying or storing desired program code in the form of instructions or data structures and accessible by a computer media, but not limited thereto.

The memory 303 is used to store application program codes for executing the solution of the present application, and the execution is controlled by the processor 301 . The processor 301 is configured to execute the application program code stored in the memory 303, so as to realize the contents shown in the foregoing method embodiments.

The second aspect of the embodiment of the present application provides a computer-readable storage medium on which a computer program is stored. When the computer program is executed by a processor, the method shown in FIG. 4 is implemented. The specific process can refer to the method in FIG. 4 The description of the embodiment will not be repeated here.

Compared with the prior art, the computer-readable storage medium utilizes the operation steps in the hemodialysis process to obtain the necessary viscosity system parameters in the viscosity detection process in advance in the pre-flushing stage, so as to facilitate the later calculation process of blood viscosity. Data basis, when the patient is undergoing hemodialysis, it is convenient to accurately calculate the blood viscosity of the patient. The embodiment of this application perfectly combines the blood viscosity detection with the hemodialysis process, and effectively integrates the viscosity detection into the hemodialysis process. During the blood treatment stage The blood viscosity of the patient can be detected and monitored in real time, which has strong practicality and convenience; in addition, in the embodiment of the present application, the method of determining the blood viscosity by skillfully utilizing the pressure change with time when the fluid medium is inhaled can be effectively Accurately obtain the blood viscosity value, the detection cost is low, the detection feasibility is high, the detection reliability is high, and the blood viscosity can be detected in real time during the hemodialysis process, so as to provide reference for the medical staff to evaluate the hemodialysis effect according to the blood viscosity , to prevent patients from cardiovascular and other related complications, thereby further ensuring the safety of patients undergoing hemodialysis, and overcoming the inability to detect the patient's blood viscosity during hemodialysis in the prior art, resulting in low safety of patients' hemodialysis treatment The problem.

It should be understood that although the various steps in the flow chart of the accompanying drawings are displayed sequentially according to the arrows, these steps are not necessarily executed sequentially in the order indicated by the arrows. Unless otherwise specified herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least some of the steps in the flowcharts of the accompanying drawings may include multiple sub-steps or multiple stages, and these sub-steps or stages are not necessarily executed at the same time, but may be executed at different times, and the order of execution is also It is not necessarily performed sequentially, but may be performed alternately or alternately with at least a part of other steps or sub-steps or stages of other steps.

Although the present disclosure is disclosed as above, the protection scope of the present disclosure is not limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present disclosure, and these changes and modifications will all fall within the protection scope of the present invention.

Claims (10)

1. A kind of blood purification equipment, it is characterized in that, described blood purification equipment comprises: slender tube, power assembly, dialyzer, arterial line, venous line, pressure sensor, processor and memory, described arterial line It is connected with the blood input end of the dialyzer, the venous line is connected with the blood output end of the dialyzer, the first end of the elongated tube is connected with the venous line, and the The second end is connected to the power assembly, and the processor is electrically connected to the memory and the pressure sensor through a bus; The pressure sensor is used to measure the liquid pressure of the elongated tube to obtain pressure measurement data; The memory stores program instructions executable by the processor, and the processor calls the program instructions to perform the following methods: Outputting the replacement fluid to the arterial line, the dialyzer, and the venous line, and outputting the replacement fluid to the elongated tube through the power assembly according to the preflush start command output by the user; calculating the displacement fluid pressure change amount of the elongated tube and the displacement fluid pressure change time of the elongated tube according to the pressure measurement data; determining the parameters of the viscosity system according to the preset viscosity of the replacement fluid, the amount of change in pressure of the replacement fluid in the elongated tube, and the change time of the pressure of the replacement fluid in the elongated tube; Dialyze the blood through the dialyzer according to the blood therapy instruction output by the user, and output the dialyzed blood to the elongated tube through the power assembly; calculating a first blood pressure change amount of the elongated tube and a first blood pressure change time of the elongated tube according to the pressure measurement data; The first blood viscosity is determined according to the viscosity system parameter, the first blood pressure change amount of the elongated tube, and the first blood pressure change time of the elongated tube. 2. The blood purification device according to claim 1, wherein the pressure sensor is located at the first end of the elongated tube; The calculating the displacement fluid pressure variation of the elongated tube according to the pressure measurement data includes: If the total amount of replacement fluid connected to the elongated tube is greater than or equal to the preset volume, the pressure sensor measures the pressure value of the replacement fluid in the elongated tube, and according to the pressure value of the replacement fluid in the elongated tube and the pressure value of the slender tube not connected to the replacement fluid, and calculate the change in the replacement fluid pressure of the slender tube; The calculating the first blood pressure variation of the elongated tube according to the pressure measurement data includes: If the total amount of blood inserted into the slender tube is greater than or equal to the preset volume, the blood pressure value of the slender tube is measured by the pressure sensor, and according to the blood pressure value of the slender tube and the the pressure value of the elongated tube not connected to the blood, and calculate the first blood pressure variation of the elongated tube; Or, the pressure sensor includes a first pressure sensor and a second pressure sensor, the first pressure sensor is located at the first end of the elongated tube, and the second pressure sensor is located at the second end of the elongated tube ; The calculating the displacement fluid pressure variation of the elongated tube according to the pressure measurement data includes: After the slender tube is connected to the replacement fluid, the pressure value of the replacement fluid at the first end of the slender tube is detected by the first pressure sensor to obtain a first pressure detection value, and the second pressure sensor detects the pressure value of the replacement fluid at the first end of the slender tube Detecting the displacement fluid pressure value at the second end of the elongated tube to obtain a second pressure detection value, and calculating the pressure value of the elongated tube according to the difference between the first pressure detection value and the second pressure detection value Changes in displacement fluid pressure; The calculating the first blood pressure variation of the elongated tube according to the pressure measurement data includes: After the elongated tube is connected to the blood, the blood pressure value at the first end of the elongated tube is detected by the first pressure sensor to obtain a third pressure detection value, and the second pressure sensor is used to detect the blood pressure value at the first end of the elongated tube. The blood pressure value at the second end of the elongated tube is obtained to obtain a fourth pressure detection value, and the first pressure of the elongated tube is calculated according to the difference between the third pressure detection value and the fourth pressure detection value. Changes in blood pressure. 3. The blood purification device according to claim 1, characterized in that, according to the blood treatment instruction output by the user, the blood is dialyzed through the dialyzer, and the dialyzed blood is output to the Before the elongated tube, the processor is further configured to perform: It is judged whether the time when the arterial line is connected to the replacement fluid is longer than the preset pre-flushing time, and if the time when the arterial line is connected to the replacement fluid is longer than the preset pre-flushing time, then a blood drainage start command is issued. 4. The blood purification device according to claim 3, further comprising: a blood detector, the blood detector is arranged on the venous line, and is used to detect whether there is blood in the venous line; The processor is also configured to perform: According to the blood extraction start command output by the user, the blood is output to the arterial line, the dialyzer and the venous line, and when the blood detector detects that there is blood in the venous line, the The power assembly outputs blood to the elongated tube; calculating a second blood pressure change amount of the elongated tube and a second blood pressure change time of the elongated tube according to the pressure measurement data; The second blood viscosity is determined according to the viscosity system parameter, the second blood pressure change amount of the elongated tube, and the second blood pressure change time of the elongated tube. 5. The blood purification device according to claim 4, wherein the processor is further configured to perform: according to the difference between the first blood viscosity and the second blood viscosity, determine whether the dialysis The dehydration effect of the device. 6. The blood purification device according to claim 5, characterized in that, If it is judged that the difference between the first blood viscosity and the second blood viscosity satisfies the first preset condition, the dehydration effect of the dialyzer is poor, and a first prompt is issued; If it is determined that the difference between the first blood viscosity and the second blood viscosity satisfies a second preset condition, the dehydration effect of the dialyzer is good, and a second prompt is issued; If it is judged that the difference between the first blood viscosity and the second blood viscosity satisfies the third preset condition, the dehydration effect of the dialyzer is good, and a third prompt is issued; Wherein, the first preset condition is: |first blood viscosity-second blood viscosity|≤first preset difference; The second preset condition is: first preset difference<|first blood viscosity-second blood viscosity|≤second preset difference; The third preset condition is: second preset difference<|first blood viscosity−second blood viscosity|. 7. The blood purification device according to claim 1, further comprising: a first temperature sensor and a second temperature sensor, the first temperature sensor is used to detect the blood temperature in the arterial pipeline, and obtain The first detection temperature, the second temperature sensor is used to detect the blood temperature in the venous line to obtain the second detection temperature; The processor is also configured to perform: judging whether the absolute value of the difference between the first detected temperature and the second detected temperature is smaller than a preset temperature difference, if the difference between the first detected temperature and the second detected temperature is If the absolute value is smaller than the preset temperature difference, then the first blood viscosity is determined according to the viscosity system parameters, the first blood pressure change amount of the elongated tube, and the first blood pressure change time of the elongated tube. 8. The blood purification device according to claim 1, further comprising: a display screen, the first blood pressure change amount of the elongated tube and the first blood pressure change amount of the elongated tube according to the viscosity system parameters A change time of blood pressure, after determining the first blood viscosity, the processor is further configured to display the change curve of the first blood viscosity with time through the display screen. 9. The blood purification device according to claim 1, characterized in that, according to the viscosity system parameter, the first blood pressure change amount of the elongated tube and the first blood pressure change time of the elongated tube, After determining the first blood viscosity, the processor is further configured to execute: Detect whether the blood in the venous line has coagulation phenomenon, and if the blood in the venous line has coagulation phenomenon, issue a fault prompt operation; and / or, After calculating the displacement fluid pressure change amount of the elongated tube and the displacement fluid pressure change time of the elongated tube according to the pressure measurement data, and according to the preset viscosity of the displacement fluid, the elongated tube Before determining the viscosity system parameters, the processor is further configured to perform: Detect whether there are bubbles in the replacement fluid in the venous line, and if there are bubbles in the replacement fluid in the venous line, calibrate the pressure change of the replacement fluid in the slender tube, and Viscosity, the displacement fluid pressure variation of the elongated tube after calibration and the displacement fluid pressure variation time of the elongated tube are used to determine the viscosity system parameters. 10. A computer-readable storage medium, on which a computer program is stored, characterized in that, when the computer program is executed by a processor, the following method is implemented: Output the replacement fluid to the arterial line, dialyzer, and venous line according to the preflush start command output by the user, and output to the slender tube through the power component; calculating the displacement fluid pressure change amount of the elongated tube and the displacement fluid pressure change time of the elongated tube according to the pressure measurement data; determining the parameters of the viscosity system according to the preset viscosity of the replacement fluid, the amount of change in pressure of the replacement fluid in the elongated tube, and the change time of the pressure of the replacement fluid in the elongated tube; Dialyze the blood through the dialyzer according to the blood therapy instruction output by the user, and output the dialyzed blood to the elongated tube through the power assembly; calculating a first blood pressure change amount of the elongated tube and a first blood pressure change time of the elongated tube according to the pressure measurement data; The first blood viscosity is determined according to the viscosity system parameter, the first blood pressure change amount of the elongated tube, and the first blood pressure change time of the elongated tube.

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