CN115669652B - A new type of highly effective pyrethroid insecticide aerosol - Google Patents
A new type of highly effective pyrethroid insecticide aerosol Download PDFInfo
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Abstract
本发明公开了一种新型高效拟除虫菊酯杀虫气雾剂，包括以下重量百分比的组分：0.01％‑2％的组分A、0.01％‑2％的组分B、0.1％‑70％的组分C、26％‑99.88％的组分D；所述的组分A为式I所示的化合物；所述的组分B为残杀威、噁虫酮、拟除虫菊酯类杀虫剂中的任意一种、两种及以上以任意比例混合而成的混合物；所述的组分C为溶剂；所述的组分D为推进剂；本发明的杀虫气雾剂组合物对蚊、蝇、德国小蠊等害虫具有击倒速度快，致死率高的优点。 The invention discloses a novel high-efficiency pyrethroid insecticide aerosol, comprising the following components in percentage by weight: 0.01%-2% of component A, 0.01%-2% of component B, 0.1%-70% of component C, and 26%-99.88% of component D; the component A is a compound shown in formula I; the component B is any one of propoxur, mefenamic acid, and pyrethroid insecticides, or a mixture of two or more of the same in any proportion; the component C is a solvent; and the component D is a propellant. The insecticide aerosol composition has the advantages of fast knockdown speed and high mortality rate to pests such as mosquitoes, flies, and German cockroaches.
Description
Technical Field
The invention relates to an insecticidal aerosol, in particular to a novel high-efficiency pyrethroid insecticidal aerosol which is used for preventing and controlling mosquito, fly or German cockroach and other sanitary pests.
Background
The pyrethroid compound shown in the formula I is a novel sanitary insecticide, and has good basic activity for preventing and controlling sanitary pests; the pyrethroid compound shown in the formula I can be prepared according to the following reaction route:
Wherein R is methyl or ethyl, M is sodium or potassium and R1 is hydrogen.
For example, 3-formyl-2, 2-dimethyl cyclopropane carboxylic acid methyl ester (CAS No. 62138-41-4) is used as a starting material, acetonitrile is subjected to condensation reaction for 4 hours under the action of sodium ethoxide at 60 ℃, olefine hydrochloric acid is added to neutralize pH to 8, ethyl acetate and water solution are added, and an oil layer is desolventized to obtain an intermediate 3- (2-cyano-1-vinyl) -2, 2-dimethyl cyclopropane carboxylic acid methyl ester.
Adding 2,3,5, 6-tetrafluorobenzyl alcohol, catalytic amount of tetraisopropyl titanate and toluene solvent into the obtained 3- (2-cyano-1-vinyl) -2, 2-dimethylcyclopropane carboxylic acid methyl ester, slowly heating to reflux to obtain byproduct methanol, controlling in a gas phase, cooling to 0-5 ℃ after the raw materials are completely converted, dropwise adding a small amount of water, separating liquid, and desolventizing to obtain the pyrethroid compound shown in the formula I.
The pyrethroid compound of the formula I with a corresponding configuration can be obtained by taking cyclopropane carboxylic acid esters with different single configurations as starting materials, for example, methyl (1R, 3R) -3-formyl-2, 2-dimethylcyclopropane carboxylate (CAS number 27335-33-7) is used as the starting materials for synthesis, the product of the chrysanthemic acid part 1R,3R is obtained, distributed crystallization is carried out, and double bond CN group Z and E isomers are separated, so that single 2,3,4, 5-tetrafluorobenzyl- (1R, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate or 2,3,4, 5-tetrafluorobenzyl- (1R, 3R) -3- [ (1E) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate can be obtained. With methyl (1R, 3S) -3-formyl-2, 2-dimethylcyclopropanecarboxylate (CAS No. 55701-02-5), 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- (-2-cyano-1-vinyl) -2, 2-dimethylcyclopropylcarboxylate or 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate or 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1E) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate can be obtained.
The pyrethroid compound has the advantages of high efficiency, low toxicity, low residue and the like, has better insecticidal activity for preventing and controlling mosquito, fly, german cockroach and other sanitary pests, and has been used for many years and is widely known. However, with years of use, sanitary pests such as mosquitoes, flies, or german cockroaches have developed resistance to some conventional pesticides, resulting in a decrease in control efficiency.
Disclosure of Invention
The invention aims to solve the technical problems in the prior art, and provides a novel high-efficiency pyrethroid insecticidal aerosol which takes a pyrethroid compound shown in a formula (I) as a main component and has very good control effect on sanitary pests such as mosquitoes, flies, german cockroaches, american cockroaches, bed bugs, ants, fleas and the like, and a preparation method and application of the insecticidal aerosol in the aspect of controlling the sanitary pests.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the novel efficient pyrethroid insecticidal aerosol comprises the following components in percentage by weight: 0.01% -2% of component A, 0.01% -2% of component B, 0.1% -70% of component C and 26% -99.88% of component D;
The component A is a compound shown in a formula I, namely 2,3,4, 5-tetrafluorobenzyl-3- [ -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate;
the component B is a mixture formed by mixing any one, two or more than two of propoxur, oxadiazon and pyrethroid pesticides in any proportion;
the component C is a solvent; the component D is a propellant;
In the above technical scheme, the component A shown in the formula I has stereoisomers due to the fact that the chrysanthemic acid part has asymmetric carbon atoms, and the component A is a mixture formed by mixing any one of all stereoisomers in the compound shown in the formula I, two or more of the stereoisomers in any proportion.
In the above technical scheme, the component A shown in the formula I is preferably 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate; namely, a compound in which the three-membered ring of the chrysanthemic acid moiety has a steric structure of 1R and is in trans form.
In the technical proposal, the utility model has the advantages that, the component B is preferably propoxur, oxadiazon, tetramethrin, phenothrin, fenpropathrin, permethrin, cypermethrin beta-cypermethrin, deltamethrin, cis-cypermethrin, cyfluthrin, beta-cypermethrin, beta-cyperme any one, two or more of lambda-cyhalothrin, methoxyl bifenthrin, tetrafluoromethyl ether bifenthrin, tetrafluoro-phenothrin and tetrafluoro-etherpyrethrin are mixed according to any proportion.
In the technical scheme, the solvent is an alkane solvent with the carbon number of 8-18; water; dodecylbenzene, decadecylbenzene; amide solvents such as N, N-dimethyl-sunflower amide; gamma-butyrolactone; monoester solvents such as methyl oleate, isopropyl tridecanoate, isopropyl myristate, isopropyl palmitate, isopropyl phenylacetate, ethyl phenylacetate, and n-butyl myristate; di-esters solvents such as diisopropyl glutarate, diisopropyl adipate, diisobutyl adipate, etc.; triester solvents such as tributyl citrate and acetyl tributyl citrate; alcohol ether solvents such as triethylene glycol monobutyl ether, diethylene glycol monobutyl ether, and propylene glycol methyl ether; and C2-8 alcohol solvent, or a mixture of two or more of them in any proportion.
In the above technical solution, the C8-18 alkane solvent is preferably any one of D60 (elkesen mobil petrochemical company), D80 (elkesen mobil petrochemical company), D100 (elkesen mobil petrochemical company), D110 (elkesen mobil petrochemical company), isopar-E (elkesen mobil petrochemical company), isopar-G (elkesen mobil petrochemical company), isopar-H (elkesen mobil petrochemical company), isopar-L (elkesen mobil petrochemical company), isopar-M (elkesen mobil petrochemical company), octane, nonane, quinine, undecane, dodecane, tridecane, tetradecane, pentadecane, hexadecane, and mixtures of two or more of them in any ratio.
In the above technical scheme, the alcohol solvent of C2-8 is preferably any one, two or more of ethanol, isopropanol, n-propanol, n-butanol, sec-butanol, tert-butanol, n-pentanol and its isomer, n-hexanol and its isomer, n-heptanol and its isomer, n-octanol and its isomer, and a mixture of any two or more of them.
In the above technical scheme, the propellant is any one of liquefied petroleum gas, propane, dimethyl ether or compressed air.
The novel efficient pyrethroid insecticidal aerosol can be added with synergists (such as PBO and the like), fragrances, antioxidants (such as BHA, BHT, antioxidants 1135, antioxidants 1076 and the like) according to the use requirement.
The invention also provides application of the novel efficient pyrethroid insecticidal aerosol in preventing and controlling sanitary pests.
In the above technical scheme, the sanitary insect pests refer to mosquitoes, flies, german cockroaches, american cockroaches, bed bugs, ants, fleas, bees and the like.
In the above technical scheme, the sanitary insect pests preferably refer to culex pallidum, culex tiredness, culex trilobata, aedes albopictus, aedes aegypti, anopheles sinensis, anopheles stephaniae tetrandrae, house flies, city flies, chrysomyia megacephala, lucilia sericata, aeruginosa, liriomyza glabra, campylomyza sativae, german cockroaches, american cockroaches, bed bugs, ants, fleas, bees, hornet, bees, bumblebees, wasps and the like.
The preparation method of the novel efficient pyrethroid insecticidal aerosol is as follows: the components A, B and solvent (and the synergistic agent, aromatic agent and bactericide according to the situation) are mixed together at room temperature or under heating, and then added into a tank with a control valve, and propellant is added into the tank under the action of pressure through the control valve to obtain the compound fertilizer.
The novel high-efficiency pyrethroid insecticidal aerosol disclosed by the invention is characterized in that when in use: the valve of the control valve is opened, high-speed air flow is generated under the pressure action of the propellant, the liquid medicine of the effective components in the tank can be dispersed and atomized by utilizing the vaporization energy of the propellant, and small fog drops are formed to suspend in the air and contact with sanitary pests such as mosquitoes, flies, cockroaches and the like, so that the purpose of rapidly controlling and killing the pests is achieved.
The insecticidal aerosol takes the pyrethroid compound shown in the formula (I), especially 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate as a main component, has the characteristics of high knockdown and death activity and low toxicity, has high activity, can reduce the usage amount of effective components in unit area, accords with the national policy of synergy and application reduction, is developed into aerosol dosage form for the first time, has low drug resistance of vector organisms and improves the control effect of the vector organisms. Proved by a pesticide effect experiment, the insecticidal aerosol has the characteristics of quick knockdown and high mortality rate on hygienic pests such as culex pallidum, housefly, german cockroach and the like, and has better control effect than a control medicament.
Detailed Description
The following detailed description of the technical scheme of the present invention is provided, but the present invention is not limited to the following descriptions:
The preparation method of the dosage form in each embodiment of the invention comprises the following steps: the composition A, the composition B, the solvent (and the synergistic agent, the aromatic agent and the bactericide according to the situation) are mixed together in the proportion under the room temperature condition, and then are added into a tank provided with a control valve, and the propellant is added into the tank under the pressure action through the control valve to prepare the composition.
The invention is illustrated below with reference to specific examples.
Formulation example 1:0.36%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.06g, permethrin 0.3g, D11044.64g, and oxetane 55g, an aerosol was prepared as described above.
Formulation example 2:0.36%2,3,4, 5-tetrafluorobenzyl- (1R, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.06g, permethrin 0.3g, D11044.64g, and oxetane 55g were prepared into aerosols according to the above methods.
Formulation example 3:0.36%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate-cypermethrin aerosol
An aerosol was produced as described above, with 0.06g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.3g of cypermethrin, 11044.66g of D, and 55g of oxetane.
Formulation example 4:2.06%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate-fenpropathrin aerosol
0.06G of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2g of fenpropathrin, D8047.94g, and 50g of compressed air were prepared into an aerosol according to the above method.
Formulation example 5:2.16%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
1.96G of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.2g of permethrin, 52.84g of isopar-E and 45g of oxetane were prepared as described above to prepare an aerosol.
Formulation example 6:2.2%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
0.2G of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2g of permethrin, 32.8g of isopar-E, 20g of isopar-L and 45g of propinebe were prepared into an aerosol according to the above method.
Formulation example 7:0.36%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.06g, permethrin 0.3g, ethanol 44.64g, and oxetane 55g, an aerosol was prepared as described above.
Formulation example 8:0.41%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.01g, permethrin 0.4g, ethanol 23.59g, n-butanol 21g, liquefied petroleum gas 55g, and aerosol was prepared as described above.
Formulation example 9:0.66%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate phenylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.06g, phenothrin 0.2g, permethrin 0.4g, D8023.34g, tridecane 10g, isopar-M10 g, piperonyl butoxide 1g, and oxetane 55g, an aerosol was prepared as described above.
Formulation example 10:0.36%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate oxadiazon aerosol
0.06G of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.3g of oxadiazon, 11044.64g of D, 55g of propane and butane were prepared into aerosols according to the above methods.
Formulation example 11:0.36%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.06g, permethrin 0.3g, isopropyl alcohol 14.64g, water 30g, and oxetane 55g, an aerosol was prepared as described above.
Formulation example 12:0.56%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.16g, permethrin 0.4g, n-butanol 4.44g, ethanol 15g, water 30g, and propinebe 50g, an aerosol was prepared as described above.
Formulation example 13:1.36%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.36g, permethrin 1g, n-heptanol 3.44g, sodium benzoate 0.2g, ethanol 20g, water 30g, dimethyl ether 45g, an aerosol was prepared as described above.
Formulation example 14:0.84%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate propoxur cypermethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.04g, propoxur 0.4g, cypermethrin 0.4g, D8023.16g, D11021g, and propineb 55g were prepared into aerosols as described above.
Formulation example 15:0.68%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate propoxur aerosol
An aerosol formulation was prepared as described above, with 0.08g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.6g of propoxur, D6024.32g, D8025g, and 50g of propinebe.
Formulation example 16:0.58%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate deltamethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.08g, deltamethrin 0.5g, tridecane 29.42g, D11020g, and propinebe 50g were prepared as above.
Formulation example 17:1.24%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate propoxur Gao Xiaofu cypermethrin aerosol
0.04G of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.8g of propoxur, 0.4g of lambda-cyhalothrin, 23.76g of pentadecane, 11020g of D, and 55g of dimethyl ether were prepared into aerosols by the above-mentioned method.
Formulation example 18:1.36%2,3,4, 5-tetrafluorobenzyl- (1S, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
0.36G of 2,3,4, 5-tetrafluorobenzyl- (1S, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 1g of permethrin, 48.64g of ethanol and 50g of dimethyl ether were prepared into an aerosol according to the method described above.
Formulation example 19:1.24%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate propoxur oxadiazon aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.04g, propoxur 0.6g, oxadiazon 0.6g, dodecane 22.76g, D11025g, and propinebe 51g were prepared as above.
Formulation example 20:0.84%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate oxadiazon-cypermethrin aerosol
0.04G of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.3g of oxadiazon, 0.5g of cypermethrin, D8023.16g, D11020g and 56g of compressed air were prepared into aerosols according to the above methods.
Formulation example 21:2.2%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 2g, permethrin 0.2g, isopar-E31.8 g, isopar-L21 g, and oxetane 45g, an aerosol was prepared as described above.
Formulation example 22:0.68%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate tetrafluoromethyl ether pyrethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.08g, transfluthrin 0.3g, phenothrin 0.3g, tridecane 29.02g,D11020g,PBO 1g,BHT 0.3g, and propineb 49g, an aerosol was prepared as described above.
Formulation example 23:0.59%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate bifenthrin deltamethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.09g, bifenthrin 0.2g, deltamethrin 0.3g, tridecane 29.41g, D11020g, and oxetane 50g were prepared as above to obtain an aerosol.
Formulation example 24:0.73%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate-methotrexate-permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.03g, methotrexate 0.2g, permethrin 0.5g, tridecane 29.27g, D11020g, and oxetane 50g were prepared as above to obtain an aerosol.
Formulation example 25:0.5%2,3,4, 5-tetrafluorobenzyl- (1S, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
An aerosol was produced as described above with 0.1g of 2,3,4, 5-tetrafluorobenzyl- (1S, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.4g of permethrin, 11044.5g of D, 55g of propiane.
Formulation example 26:0.02%2,3,4, 5-tetrafluorobenzyl- (1S, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
0.01G of 2,3,4, 5-tetrafluorobenzyl- (1S, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.01g of permethrin, D1100.1g, and 99.88g of compressed air were prepared into an aerosol according to the above method.
Formulation example 27:4%2,3,4, 5-tetrafluorobenzyl- (1S, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1S, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 2g, beta-cypermethrin 2g, ethanol 70g, and oxetane 26g were prepared into aerosols according to the above methods.
Formulation example 28:0.5%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate tetrafluorofenthrin-cis-cypermethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.1g, transfluthrin 0.2g, cyhalothrin 0.2g, diisopropyl adipate 44.5g, and probutane 55g were prepared as described above to prepare an aerosol.
Formulation example 29:0.6%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
2,3,4, 5-Tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate 0.2g, permethrin 0.4g, isopropyl myristate 29.4g, tributyl citrate 20g, and probutane 50g, an aerosol was prepared as described above.
Formulation example 30:0.36%2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate propoxur aerosol
0.06G of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.3g of propoxur, D11044.64g and 55g of propinebe were prepared as described above.
Formulation example 31:0.36%2,3,4, 5-tetrafluorobenzyl-3- [ -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate permethrin aerosol
0.06G of 2,3,4, 5-tetrafluorobenzyl-3- [ -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.3g of permethrin, 11044.64g of D, 55g of propinebe, was prepared as described above.
Control agent 1:0.6% tetramethrin-permethrin aerosol (commercially available, composed of 0.3% tetramethrin +0.3% permethrin)
And (3) drug effect verification test:
test agent: formulation examples 1, 2, 3, 7, 9,10, 11, 19, 30, 31 of the invention and control agent 1
Testing insects: female imago without sucking blood 3-5 days after the light culex mosquito emerges
Housefly, adult on day 3-4 after emergence, male and female are half
German cockroach, adult of 10-15 days old, male and female half
The test method comprises the following steps: referring to GB/T13917.2-2009 indoor efficacy test of hygienic insecticide for pesticide registration and evaluation part 2: aerosol methods.
Mosquitoes, flies: a cylindrical device is used. The specific method is that the test insects (30 flies or 30 mosquitoes) are put into a jar, after the test insects return to normal activities, the aerosol cylinder to be tested is in a horizontal shape, the nozzle is vertical downwards and is aligned to the spraying hole, the medicine (1.0+/-0.1G) is sprayed, and the round hole is immediately plugged by a rubber plug (G). 1min, the pulling plate (A) is pulled out, the time is immediately counted, and the number of knocked-down insects is recorded at regular intervals. And (3) transferring the knocked-down test insects to a clean insect raising cage for 20min, recovering the raising standard, feeding with 5% sugar cotton balls, checking the dead insects for 24h, and calculating the number of the non-knocked-down test insects according to the living insects. The test should be repeated three times or more. At the end of each test, the test device should be cleaned.
Cockroach: a cylinder device is adopted, and a pull plate is not needed. Placing 20 German cockroaches on the upper part of the inner wall, coating vaseline on the upper part of the inner wall, sealing the inner wall with a B barrel with a 12-mesh iron screen, placing the aerosol barrel horizontally after the test insects return to normal activities, vertically aligning the spray nozzle downwards with the spray hole on E, spraying the medicament (1.0+/-0.1G), immediately plugging the round hole with a rubber plug (G), starting timing, recording the number of knocked-down test insects at regular intervals, transferring all the test insects into a cleaning vessel for 20min, returning to standard feeding, feeding with a mixed feed block and a soaked cotton ball, and checking the number of dead insects for 72 h. The test should be repeated three times or more. At the end of each test, the test apparatus should be cleaned and the detailed results are shown in the following table:
TABLE 1 results of the efficacy test of the above aerosols against culex pallidum, housefly and German cockroach
As can be seen from Table 1, the aerosol of the present invention has good killing effect on culex light-colored, housefly and German cockroach.
The foregoing examples are merely illustrative of the technical concept and technical features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the essence of the present invention should be included in the scope of the present invention.
Claims (6)
1. The novel efficient pyrethroid insecticidal aerosol is characterized by comprising the following components in percentage by weight: 0.01% -2% of component A, 0.01% -2% of component B, 0.1% -70% of component C and 26% -99.88% of component D;
The component A is a compound shown in a formula I, namely 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate;
the component B is propoxur, oxadiazon, phenothrin, fenpropathrin permethrin, cypermethrin, bifenthrin bifenthrin, methotrexate any one, two or more of the tetrafluoromethyl ether pyrethrin, the tetrafluorobenzene pyrethrin and the tetrafluoroether pyrethrin are mixed according to any proportion;
the component C is a solvent; the component D is a propellant;
2. the novel high-efficiency pyrethroid insecticidal aerosol according to claim 1, wherein the solvent is any one of, water, dodecylbenzene, N-dimethyl-sunflower amide, γ -butyrolactone, methyl oleate, isopropyl tridecanoate, isopropyl myristate, isopropyl palmitate, isopropyl phenylacetate, ethyl phenylacetate, N-butyl myristate, diisopropyl glutarate, diisobutyl adipate, tributyl citrate, tributyl acetylcitrate, triethylene glycol monobutyl ether, diethylene glycol monobutyl ether, propylene glycol methyl ether, and alcohol solvents of C2-8, and a mixture of two or more thereof in any ratio.
3. The novel high-efficiency pyrethroid insecticidal aerosol according to claim 1, wherein the propellant is any one of liquefied petroleum gas, propane, dimethyl ether or compressed air.
4. Use of a novel high-efficiency pyrethroid insecticidal aerosol as defined in any one of claims 1 to 3 for controlling sanitary pests.
5. The method according to claim 4, wherein the sanitary insect pest is mosquito, fly, german cockroach, american cockroach, bed bug, ant, flea, bee.
6. The use according to claim 5, wherein said hygienic insect pest is culex pallidum, culex tiredness, culex trichinensis, aedes albopictus, aedes aegypti, anopheles sinensis, anopheles stephania, anopheles sinensis, midge, chrysomyia megacephala, lucilia sericata, copperus, liriomyza, campylomyza, german cockroach, american cockroach, bed bug, ant, flea, bee, wasp, bumblebee.
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