CN115554213B - Anti-hair loss shampoo with nano-particle size lipid coated with arginine and preparation method thereof - Google Patents
Anti-hair loss shampoo with nano-particle size lipid coated with arginine and preparation method thereof Download PDFInfo
- Publication number
- CN115554213B CN115554213B CN202210664242.5A CN202210664242A CN115554213B CN 115554213 B CN115554213 B CN 115554213B CN 202210664242 A CN202210664242 A CN 202210664242A CN 115554213 B CN115554213 B CN 115554213B
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- parts
- hair
- hair loss
- extract
- mixed solution
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- 230000003656 anti-hair-loss Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 150000002632 lipids Chemical class 0.000 title abstract description 7
- 239000004475 Arginine Substances 0.000 title abstract description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title abstract description 5
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- 239000002994 raw material Substances 0.000 claims abstract description 32
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims abstract description 29
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Classifications
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Abstract
The invention discloses an anti-hair loss shampoo with nano-particle size lipid coated arginine and a preparation method thereof, wherein the anti-hair loss shampoo comprises the following raw materials in parts by weight: 40-56 parts of water, 14-18 parts of surfactant, 2-3 parts of methyl glucose dioleate, 10-16 parts of nano liposome, 2-4 parts of germinal extract, 0.5-0.7 part of nicotinamide, 1.0-1.4 parts of pyridoxine, 1.2-2.4 parts of traditional Chinese medicine extract, 0.6-0.8 part of acetyl tyrosine, 0.5-0.9 part of hydrolyzed soy protein and 1.0-1.4 parts of vitamin H. The invention can convey L-arginine and octanoylglycine into hair follicle, thereby playing the roles of dilating blood vessels, improving hair follicle blood supply and stimulating hair growth, simultaneously helping to inhibit sebaceous gland secretion, inhibiting fungi, cooperatively controlling oil and removing dandruff, forming a good alopecia-preventing scalp environment, having high bioavailability and being easy to permeate and absorb scalp and hair follicle.
Description
Technical Field
The invention relates to the technical field of shampoos, in particular to an anti-hair loss shampoo with nano-particle size lipid coated arginine and a preparation method thereof.
Background
Chinese shampoo was first shown in the sixth seventies of the 20 th century. The shampoo is used as an indispensable daily chemical product in modern society, and can clean grease dirt attached to scalp and hair and keep the scalp and hair clean. With the continuous improvement of life quality of people, shampoo with only cleaning effect can not meet the requirements of modern society. The continuous development of the daily chemical field also enables the components of the shampoo to be continuously promoted and new.
Due to the continuously enhanced working pressure, the gradually accelerated life rhythm and the continuously worsened natural environment, more and more people are worried about alopecia, and the alopecia becomes the first major hair health problem which is confusing for people, even though a plurality of anti-alopecia shampoos are on the market to prevent alopecia, in actual use, effective substances such as L-amino acid and the like cannot be effectively sent into hair follicles, only scalp surfaces are often available, the scalp surfaces cannot be absorbed well, waste is caused, and the effect of preventing alopecia is also affected.
Disclosure of Invention
The invention aims to provide anti-hair loss shampoo with nano-particle size lipid coated with arginine and a preparation method thereof, so as to solve the problems in the prior art.
The technical scheme of the invention is realized as follows:
according to one aspect of the present invention, there is provided an anti-hair loss shampoo.
The anti-hair loss shampoo comprises the following raw materials in parts by weight:
40-56 parts of water, 14-18 parts of surfactant, 2-3 parts of methyl glucose dioleate, 10-16 parts of nano liposome, 2-4 parts of germinal extract, 0.5-0.7 part of nicotinamide, 1.0-1.4 parts of pyridoxine, 1.2-2.4 parts of traditional Chinese medicine extract, 0.6-0.8 part of acetyl tyrosine, 0.5-0.9 part of hydrolyzed soy protein and 1.0-1.4 parts of vitamin H.
Further, the nano liposome comprises the following raw materials in parts by mass: 5-8 parts of L-arginine and 5-8 parts of octanoylglycine.
Further, the hair growth extract comprises the following raw materials in parts by weight: 1-2 parts of cacumen biotae extract and 1-2 parts of saw palmetto extract.
Further, the traditional Chinese medicine extract essence comprises the following raw materials in parts by weight: ginseng essence 0.1-0.2 parts, burdock root essence 0.5-1.0 parts, fleece-flower root essence 0.6-1.2 parts.
Further, the surfactant is one or a mixture of more of sodium fatty alcohol polyoxyethylene ether sulfate, coconut diethanolamide and betaine.
According to another aspect of the present invention, there is provided a method for preparing nanoliposome, comprising the steps of:
step S101: dissolving L-arginine and octanoylglycine in phosphate buffer solution to obtain mixed solution A;
step S103: co-dissolving phospholipid and cholesterol in a solution of an organic solvent, mixing, stirring, and evaporating to remove the organic solvent to obtain a mixed solution B;
step S105: adding the mixed solution A into the mixed solution B, stirring, mixing and homogenizing to obtain primary emulsion;
step S107: and (3) performing ultrasonic dispersion on the obtained colostrum to obtain the nano liposome.
Further, the organic solvent in step S103 is one or more of chloroform or diethyl ether.
Further, in step S107, the power of ultrasonic dispersion is 150-200W, and the ultrasonic time is 5-10min.
According to another aspect of the present invention, there is provided a method for preparing an anti-hair loss shampoo, comprising the steps of:
step S201: weighing all raw materials required by the anti-hair loss shampoo according to the parts by weight;
step S203: adding the weighed water into a beaker for heating, and keeping the temperature at 45-50 ℃;
step S205: sequentially adding surfactant, methyl glucose dioleate, cacumen Platycladi extract and saw palmetto extract into a beaker, and fully mixing and stirring for 10-15min by using a magnetic stirrer to obtain a mixed solution A;
step S207: sequentially adding nicotinamide, pyridoxine, ginseng essence, burdock root essence, polygonum multiflorum essence, acetyl tyrosine, hydrolyzed soy protein and vitamin H into the mixed solution A, and fully stirring for 20-30min to obtain a mixed solution B;
step S209: and finally, adding the prepared nano liposome into the mixed solution B, fully stirring for 6-8min, and homogenizing to obtain the hair loss preventing shampoo.
Further, the rotating speed of the magnetic stirrer is 300-400r/min.
The raw material components adopted by the invention are as follows:
methyl glucose dioleate: the emulsion is used as an emulsifying agent, a solubilizing agent and the like, and has excellent emulsifying, dispersing and solubilizing capabilities. Good compatibility with skin, and is used as a thickener for shampoos;
nicotinamide: is a water-soluble vitamin and is a member of the vitamin B group. The niacin can be converted into nicotinamide in vivo, and has important effects on skin aging resistance, such as relieving and preventing skin darkness and yellowing generated in the early aging process, improving skin resistance, preventing and treating niacin deficiency diseases such as pellagra, repairing stratum corneum well, and strengthening self-defense capability of skin;
pyridoxine: the vitamin B6 is also called as a water-soluble vitamin, has the main functions of controlling oil and resisting lipid overflow in cosmetics and skin care products, is safer, can be used safely, can reduce the generation of dark yellow pigment, is a water-soluble substance, is an indispensable component for human bodies, and can be used for conditioning oil;
acetyl tyrosine: N-acetyl-L-tyrosine. The acetyl tyrosine has the main functions of whitening and removing freckles in cosmetics and skin care products, is safer, can be used safely, is an efficient and safe amino acid whitening agent, and induces tyrosinase, thereby reducing melanin generation;
hydrolysis of soy protein: the hair conditioner, the humectant, the safe and safe hair conditioner and the skin care product are the ideal natural moisturizing factors, and natural ingredients for promoting metabolism and maintenance functions of skin tissues in women;
vitamin H: vitamin h is a water-soluble vitamin which can help the hair grow again, has great effect on the growth of substances in the human body and the health of the human body, can promote the metabolism of the human body, supplement some nutrients for the growth of roots and has a certain effect on the growth of the hair, and the vitamin h can promote the growth of the hair;
l-arginine: which increases the nitric oxide levels in the body, the body requires L-arginine and produces nitrogen therefrom. Nitric oxide increases blood flow, relaxes blood vessels, and stimulates hair growth;
octanoylglycine: the main functions of the skin conditioner, the antibacterial agent and the humectant in cosmetics and skin care products are that the skin conditioner, the antibacterial agent and the humectant have a strong inhibition effect on staphylococcus epidermidis, propionibacterium acnes and the like, can inhibit excessive secretion of sebum, and have a remarkable effect on preventing and treating acne;
extract of biota orientalis: the extract of the biota orientalis is branch tips and leaves of biota orientalis of Cupressaceae, has the effects of cooling blood, stopping bleeding, growing hair, blackening hair and the like, wherein the extract of the biota orientalis can be purchased or prepared by the method of the embodiment 1 with the application number of CN 114470012A;
saw palmetto extract: the saw palmetto extract is prepared from saw palmetto oil extracted from saw palmetto fruits as a raw material, beta-cyclodextrin as an auxiliary material, and an oil wrapping process is adopted to convert the saw palmetto oil into a powdery product, so that the preparation and the administration are facilitated, the activity of 5 alpha-reductase is inhibited, the production of dihydrotestosterone is prevented, androgenic alopecia is prevented, the signal expression of hair follicle growth factors is stimulated, hair mother cells are activated, the transition from telogen to developmental stage is promoted, the normal growth of hair is assisted, and the hair loss is regulated by regulating the self-growth system of hair follicles;
ginseng essence: the active substances extracted from ginseng can be purchased or prepared, and the preparation method can be obtained by grinding and drying according to the method of the embodiment 1 with the application number of CN108853163B, and has the effects of moistening hair, removing dandruff, improving hair breakage, nourishing scalp, improving dandruff, enabling hair to be more flexible, promoting hair growth better and relieving alopecia problems of some people. Is also helpful for improving immunity and strengthening body;
july burdock root essence: the preparation method is particularly effective in reducing scalp oil, regulating scalp flora balance, repairing and activating scalp cells, improving scalp environment, and has no stimulation to scalp, and can be obtained by purchasing or preparing the extract according to the method of the example 1 with the application number of CN102526154A, and drying and grinding the extracted extract;
polygonum multiflorum essence: the hair cream can be purchased or prepared by a preparation method which can be obtained by drying and grinding the extracted extractum according to the method of the embodiment 1 with the application number of CN103405516B, can change the blood circulation in hair, promote the absorption of hair, control the secretion of more sebum, make the skin become more black and soft, look more glossy, and have the simple and convenient combing and can also play a role in assisting in improving the white hair into black hair.
Compared with the prior art, the invention has the beneficial effects that:
(1) The L-arginine and the octanoyl glycine are wrapped by adopting the nano liposome and have strong similarity with cell membranes, so that the liposome is easy to fuse with cells, a special structure of the liposome can carry hydrophilic and lipophilic functional components to enter the cells to play a role, so that the effective components can more easily permeate into skin cells, and then the L-arginine and the octanoyl glycine can be conveyed into hair follicles, so that the effects of dilating blood vessels, improving hair follicle blood supply and stimulating hair growth can be exerted, and meanwhile, the effects of inhibiting sebaceous gland secretion, inhibiting fungi, cooperatively controlling oil and removing dandruff are achieved, a good alopecia-preventing scalp environment is formed, and the nano liposome has high bioavailability and is easy to permeate and absorb scalp and hair follicles;
(2) By adding the precious Chinese herbal medicines into the shampoo, the hair conditioner has the effects of moistening hair, removing dandruff, improving hair breakage, nourishing scalp and improving dandruff, can make hair become more flexible, can better promote hair growth, and can alleviate alopecia problems of some people. The hair-blackening agent is helpful for improving the immunity of the body, strengthening the body, and can also play a role in assisting in improving the white hair to black hair;
(3) The added cacumen biotae extract and saw palmetto extract can promote hair growth and blacken hair, inhibit 5 alpha-reductase activity, prevent dihydrotestosterone from generating, prevent androgenic alopecia, stimulate the signal expression of hair follicle growth factors, activate hair mother cells, promote the transition of telogen hair to developmental stage, help the normal growth of hair, and have the advantage of radically regulating alopecia by regulating the self-growth system of hair follicles;
(4) The water-soluble vitamins are added, so that metabolism of a human body can be promoted, nutrient substances for growing hair roots can be supplemented, the hair growth can be achieved to a certain extent, the production of dark yellow pigment can be reduced, and the water-soluble vitamin-based hair conditioner can be used for conditioning grease because the water-soluble vitamin-based hair conditioner is a water-soluble substance which is an indispensable component of the human body.
Drawings
Fig. 1 is a schematic flow chart of a method for preparing nano-liposomes in anti-hair loss shampoo according to the present invention;
fig. 2 is a schematic flow chart of a method for preparing the hair loss preventing shampoo provided by the invention.
FIG. 3 is a line graph of L-arginine content of hair follicles according to the present invention;
FIG. 4 is a line graph of octanoylglycine content of hair follicles according to the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
According to one aspect of the present invention, there is provided an anti-hair loss shampoo.
The anti-hair loss shampoo comprises the following raw materials in parts by weight:
40-56 parts of water, 14-18 parts of surfactant, 2-3 parts of methyl glucose dioleate, 10-16 parts of nano liposome, 2-4 parts of germinal extract, 0.5-0.7 part of nicotinamide, 1.0-1.4 parts of pyridoxine, 1.2-2.4 parts of traditional Chinese medicine extract, 0.6-0.8 part of acetyl tyrosine, 0.5-0.9 part of hydrolyzed soy protein and 1.0-1.4 parts of vitamin H.
The nano liposome comprises the following raw materials in parts by mass: 5-8 parts of L-arginine and 5-8 parts of octanoylglycine.
The hair growth extract comprises the following raw materials in parts by mass: 1-2 parts of cacumen biotae extract and 1-2 parts of saw palmetto extract.
The traditional Chinese medicine extract essence comprises the following raw materials in parts by weight: ginseng essence 0.1-0.2 parts, burdock root essence 0.5-1.0 parts, fleece-flower root essence 0.6-1.2 parts.
In order to more clearly understand the above technical solutions of the present invention, the following describes the above solutions of the present invention in detail by means of specific examples.
Example 1
The anti-hair loss shampoo comprises the following raw materials in parts by weight:
40g of water, 14g of surfactant, 2g of methyl glucose dioleate, 10g of nano liposome, 2g of germinal extract, 0.5g of nicotinamide, 1.0g of pyridoxine, 1.2g of traditional Chinese medicine extract, 0.6g of acetyltyrosine, 0.5g of hydrolyzed soy protein and 1.0g of vitamin H.
The nano liposome comprises the following raw materials in parts by mass: l-arginine 5g, octanoylglycine 5g.
The hair growth extract comprises the following raw materials in parts by mass: 1g of cacumen biotae extract and 1g of saw palmetto extract.
The traditional Chinese medicine extract essence comprises the following raw materials in parts by weight: ginseng essence 0.1g, burdock root essence 0.5g and fleece-flower root essence 0.6g.
Wherein the surfactant is composed of fatty alcohol polyoxyethylene ether sodium sulfate and coconut diethanolamide.
The preparation method of the nano liposome comprises the following steps:
step S101: 5g of L-arginine and 5g of octanoylglycine are dissolved in phosphate buffer solution to obtain a mixed solution A;
step S103: co-dissolving phospholipid and cholesterol in a solution of an organic solvent, mixing, stirring, and evaporating to remove the organic solvent to obtain a mixed solution B;
step S105: adding the mixed solution A into the mixed solution B, stirring, mixing and homogenizing to obtain primary emulsion;
step S107: and (3) performing ultrasonic dispersion on the obtained colostrum to obtain the nano liposome.
The preparation method of the hair loss preventing shampoo comprises the following steps:
step S201: weighing all raw materials required by the anti-hair loss shampoo according to the parts by weight;
step S203: adding 40g of weighed water into a beaker for heating, and keeping the temperature at 45-50 ℃;
step S205: sequentially adding 14g of surfactant, 2g of methyl glucose dioleate, 1g of cacumen biotae extract and 1g of saw palmetto extract into a beaker, and fully mixing and stirring for 10-15min by using a magnetic stirrer to obtain a mixed solution A;
step S207: then 0.5g of nicotinamide, 1.0g of pyridoxine, 0.1g of ginseng essence, 0.5g of arctium lappa root essence, 0.6g of polygonum multiflorum essence, 0.6g of acetyltyrosine, 0.5g of hydrolyzed soy protein and 1.0g of vitamin H are sequentially added into the mixed solution A, and fully stirred for 20-30min to obtain a mixed solution B;
step S209: and finally, adding 10g of the prepared nano liposome into the mixed solution B, fully stirring for 6-8min, and homogenizing to obtain the hair loss preventing shampoo.
Example 2:
the anti-hair loss shampoo comprises the following raw materials in parts by weight:
48g of water, 16g of surfactant, 2.5g of methyl glucose dioleate, 13g of nano liposome, 3g of germinal extract, 0.6g of nicotinamide, 1.2g of pyridoxine, 1.8g of traditional Chinese medicine extract, 0.7g of acetyltyrosine, 0.7g of hydrolyzed soy protein and 1.2g of vitamin H.
The nano liposome comprises the following raw materials in parts by mass: l-arginine 6.5g, octanoylglycine 6.5g.
The hair growth extract comprises the following raw materials in parts by mass: 1.5g of cacumen biotae extract and 1.5g of saw palmetto extract.
The traditional Chinese medicine extract essence comprises the following raw materials in parts by weight: ginseng essence 0.15g, arctium lappa root essence 0.75g, fleece-flower root essence 0.9g.
Wherein the surfactant is composed of sodium fatty alcohol polyoxyethylene ether sulfate and betaine.
The preparation method of the nano liposome comprises the following steps:
step S101: 6.5g of L-arginine and 6.5g of octanoylglycine are dissolved in phosphate buffer solution to obtain a mixed solution A;
step S103: co-dissolving phospholipid and cholesterol in a solution of an organic solvent, mixing, stirring, and evaporating to remove the organic solvent to obtain a mixed solution B;
step S105: adding the mixed solution A into the mixed solution B, stirring, mixing and homogenizing to obtain primary emulsion;
step S107: and (3) performing ultrasonic dispersion on the obtained colostrum to obtain the nano liposome.
The preparation method of the hair loss preventing shampoo comprises the following steps:
step S201: weighing all raw materials required by the anti-hair loss shampoo according to the parts by weight;
step S203: adding 48g of weighed water into a beaker for heating, and keeping the temperature at 45-50 ℃;
step S205: sequentially adding 16g of surfactant, 2.5g of methyl glucose dioleate, 1.5g of cacumen biotae extract and 1.5g of saw palmetto extract into a beaker, and fully mixing and stirring for 10-15min by using a magnetic stirrer to obtain a mixed solution A;
step S207: then 0.6g of nicotinamide, 1.2g of pyridoxine, 0.15g of ginseng essence, 0.75g of arctium lappa root essence, 0.9g of polygonum multiflorum essence, 0.7g of acetyltyrosine, 0.7g of hydrolyzed soy protein and 1.2g of vitamin H are sequentially added into the mixed solution A, and fully stirred for 20-30min to obtain a mixed solution B;
step S209: and finally, adding 13g of the prepared nano liposome into the mixed solution B, fully stirring for 6-8min, and homogenizing to obtain the hair loss preventing shampoo.
Example 3:
the anti-hair loss shampoo comprises the following raw materials in parts by weight:
56g of water, 18g of surfactant, 3g of methyl glucose dioleate, 16g of nano liposome, 4g of germinal extract, 0.7g of nicotinamide, 1.4g of pyridoxine, 2.4g of traditional Chinese medicine extract, 0.8g of acetyltyrosine, 0.9g of hydrolyzed soy protein and 1.4g of vitamin H.
The nano liposome comprises the following raw materials in parts by mass: 8g of L-arginine and 8g of octanoylglycine.
The hair growth extract comprises the following raw materials in parts by mass: 2g of cacumen biotae extract and 2g of saw palmetto extract.
The traditional Chinese medicine extract essence comprises the following raw materials in parts by weight: ginseng essence 0.2g, burdock root essence 1.0g and fleece-flower root essence 1.2g.
Wherein the surfactant is composed of sodium fatty alcohol polyoxyethylene ether sulfate, coconut diethanolamide and betaine.
The preparation method of the nano liposome comprises the following steps:
step S101: 8g of L-arginine and 8g of octanoylglycine are dissolved in phosphate buffer solution to obtain a mixed solution A;
step S103: co-dissolving phospholipid and cholesterol in a solution of an organic solvent, mixing, stirring, and evaporating to remove the organic solvent to obtain a mixed solution B;
step S105: adding the mixed solution A into the mixed solution B, stirring, mixing and homogenizing to obtain primary emulsion;
step S107: and (3) performing ultrasonic dispersion on the obtained colostrum to obtain the nano liposome.
The preparation method of the hair loss preventing shampoo comprises the following steps:
step S201: weighing all raw materials required by the anti-hair loss shampoo according to the parts by weight;
step S203: adding 56g of the weighed water into a beaker for heating, and keeping the temperature at 45-50 ℃;
step S205: sequentially adding 18g of surfactant, 3g of methyl glucose dioleate, 2g of cacumen biotae extract and 2g of saw palmetto extract into a beaker, and fully mixing and stirring for 10-15min by using a magnetic stirrer to obtain a mixed solution A;
step S207: then 0.7g of nicotinamide, 1.4g of pyridoxine, 0.2g of ginseng essence, 1.0g of burdock root essence, 1.2g of polygonum multiflorum essence, 0.8g of acetyltyrosine, 0.9g of hydrolyzed soy protein and 1.4g of vitamin H are sequentially added into the mixed solution A, and fully stirred for 20-30min to obtain a mixed solution B;
step S209: and finally, adding 16g of the prepared nano liposome into the mixed solution B, fully stirring for 6-8min, and homogenizing to obtain the hair loss preventing shampoo.
Comparative example 1
Comparative example 1 is different from example 1 in that the nanoliposome preparation step in comparative example 1 does not contain the L-arginine, and all other things are the same.
Comparative example 2
Comparative example 2 is different from example 1 in that the nanoliposome preparation step in comparative example 2 does not contain the octanoylglycine, and the other matters are the same.
Comparative example 3
Comparative example 3 is different from example 1 in that comparative example 3 does not contain the nanoliposome and the caprylylglycine, contains the L-arginine, and is otherwise identical.
Comparative example 4
Comparative example 4 is different from example 1 in that comparative example 4 does not contain the nanoliposome and the L-arginine, contains the octanoylglycine, and is otherwise identical.
Comparative example 5
Comparative example 5 is different from example 1 in that comparative example 5 does not contain the nanoliposome, contains the L-arginine and the octanoylglycine, and is otherwise identical.
In summary, by means of the technical scheme, the anti-hair loss shampoo can be invented, and the nano liposome is adopted to wrap the L-arginine and the octanoylglycine and has strong similarity with cell membranes, so that the liposome is easy to be fused with cells, a special structure of the liposome can carry hydrophilic and lipophilic functional components to enter cells to play a role, so that the effective components can permeate into skin cells more easily, and then the L-arginine and the octanoylglycine can be conveyed into hair follicles, so that the effects of dilating blood vessels, improving blood supply of the hair follicles and stimulating hair growth can be achieved, meanwhile, sebaceous gland secretion can be restrained, fungi can be restrained, oil and dandruff can be cooperatively controlled, a good anti-hair loss scalp environment can be formed, and the shampoo has high bioavailability and is easy for permeation and absorption of scalp and hair follicles.
The L-arginine and the octanoylglycine contained in the prior art without adopting the nanoliposome inclusion technology are taken down by adopting hair follicle implantation to target hair follicles of a user after the hair washing of the same volunteer by adopting the traditional L-arginine and the octanoylglycine which are contained in the nanoliposome inclusion technology, three points of the head of the volunteer are selected, wherein when two ways are detected, the interval time is 8 hours, the L-arginine in the internal hair follicle is detected,
wherein the determination of L-arginine adopts ultraviolet absorption spectrometry with a mixed solution of alpha-naphthol (methyl Cai Fen) and diacetyl as a color developing agent, wherein the changes of L-arginine and hair follicle positions are shown in the following table 1 and fig. 3:
the octanoyl glycine content is directly determined by adopting a cyano column or an amino column and adopting a high performance liquid chromatography, and the changes of the octanoyl glycine and the hair follicle point are shown in the following table 2 and fig. 4:
compared with the traditional mode and the comparative example, the invention can greatly improve the amount of L-arginine and octanoylglycine in the nano lipid body entering into hair follicles, further can make the hair follicles better absorb, further can play the roles of dilating blood vessels, improving hair follicle blood supply and stimulating hair growth, simultaneously helps to inhibit sebaceous gland secretion, inhibit fungi, cooperatively control oil and remove dandruff, and forms a good alopecia prevention scalp environment, and has high bioavailability and easy penetration and absorption of scalp and hair follicles.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (7)
1. The anti-hair loss shampoo is characterized by comprising the following raw materials in parts by weight:
40-56 parts of water, 14-18 parts of surfactant, 2-3 parts of methyl glucose dioleate, 10-16 parts of nano liposome, 2-4 parts of germinal extract, 0.5-0.7 part of nicotinamide, 1.0-1.4 parts of pyridoxine, 1.2-2.4 parts of traditional Chinese medicine extract, 0.6-0.8 part of acetyl tyrosine, 0.5-0.9 part of hydrolyzed soy protein and 1.0-1.4 parts of vitamin H;
the nano liposome comprises the following raw materials in parts by mass: 5-8 parts of L-arginine and 5-8 parts of octanoylglycine;
the hair growth extract comprises the following raw materials in parts by mass: 1-2 parts of cacumen biotae extract and 1-2 parts of saw palmetto extract;
the traditional Chinese medicine extraction essence comprises the following raw materials in parts by weight: ginseng essence 0.1-0.2 parts, burdock root essence 0.5-1.0 parts, fleece-flower root essence 0.6-1.2 parts.
2. The anti-hair loss shampoo of claim 1, wherein: the surfactant is one or more of sodium fatty alcohol polyoxyethylene ether sulfate, coconut diethanolamide and betaine.
3. The anti-hair loss shampoo of claim 1, wherein: the preparation method of the nano liposome comprises the following steps:
step S101: dissolving L-arginine and octanoylglycine in phosphate buffer solution to obtain mixed solution A;
step S103: co-dissolving phospholipid and cholesterol in a solution of an organic solvent, mixing, stirring, and evaporating to remove the organic solvent to obtain a mixed solution B;
step S105: adding the mixed solution A into the mixed solution B, stirring, mixing and homogenizing to obtain primary emulsion;
step S107: and (3) performing ultrasonic dispersion on the obtained colostrum to obtain the nano liposome.
4. A hair loss preventing shampoo according to claim 3, characterized in that: the organic solvent in step S103 is one or more of chloroform or diethyl ether.
5. A hair loss preventing shampoo according to claim 3, characterized in that: in the step S107, the ultrasonic dispersion power is 150-200W, and the ultrasonic time is 5-10min.
6. A method for preparing an anti-hair loss shampoo, which is used for preparing the anti-hair loss shampoo according to any one of claims 1-5, and comprises the following steps:
step S201: weighing all raw materials required by the anti-hair loss shampoo according to the parts by weight;
step S203: adding the weighed water into a beaker for heating, and keeping the temperature at 45-50 ℃;
step S205: sequentially adding surfactant, methyl glucose dioleate, cacumen Platycladi extract and saw palmetto extract into a beaker, and fully mixing and stirring for 10-15min by using a magnetic stirrer to obtain a mixed solution A;
step S207: sequentially adding nicotinamide, pyridoxine, ginseng essence, burdock root essence, polygonum multiflorum essence, acetyl tyrosine, hydrolyzed soy protein and vitamin H into the mixed solution A, and fully stirring for 20-30min to obtain a mixed solution B;
step S209: and finally, adding the prepared nano liposome into the mixed solution B, fully stirring for 6-8min, and homogenizing to obtain the hair loss preventing shampoo.
7. The method for preparing the hair loss preventing shampoo according to claim 6, wherein the method comprises the following steps: wherein the rotating speed of the magnetic stirrer is 300-400r/min.
Priority Applications (1)
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| JP2006241110A (en) * | 2005-03-04 | 2006-09-14 | Hokkaido Univ | Hair composition |
| CN101969921A (en) * | 2008-03-07 | 2011-02-09 | S.W.专利可恢复有限公司 | Composition and uses for influencing hair growth |
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