CN115541900A

CN115541900A - Blood analyzer and detection method thereof

Info

Publication number: CN115541900A
Application number: CN202110739601.4A
Authority: CN
Inventors: 汤诚鹏
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2021-06-30
Filing date: 2021-06-30
Publication date: 2022-12-30

Abstract

The application discloses a blood analyzer and a detection method thereof, wherein the blood analyzer comprises a mode selection module for selecting one detection mode from a plurality of detection modes of the blood analyzer, and the plurality of detection modes comprise a specific protein single detection mode; the blood routine detection module is used for performing blood routine detection on the whole blood sample; the specific protein detection module is used for detecting specific proteins of the whole blood sample; the control module is used for controlling the specific protein detection module to carry out detection when the mode selection module selects the specific protein single detection mode; when the control module judges that the detection times of the specific protein detection module are integral multiples of the preset times, the control module is used for cleaning the reaction tank corresponding to the blood routine detection module and the specific protein single detection mode by adopting a first cleaning mode. Through the mode, the hole blocking can be prevented, the detection accuracy of the blood analyzer is improved, and the use is convenient for a user.

Description

Blood analyzer and detection method thereof

Technical Field

The application relates to the technical field of blood detection, in particular to a blood analyzer and a detection method thereof.

Background

With the development of academic research and clinical examination, the blood analyzer has high practical value for joint detection of blood routine and SAA (serum amyloid A) or CRP (C-reactive protein), and can bring great help to detection and diagnosis of infection types of patients.

The conventional blood routine and specific protein joint inspection integrated machine is very easy to cause hole blockage, so that the use of a user is inconvenient.

Disclosure of Invention

In order to solve the problems, the application provides a blood analyzer and a detection method thereof, a reaction tank corresponding to a blood routine detection module and a specific protein independent detection mode is cleaned by adopting a first cleaning mode, and the occurrence of hole blockage can be prevented.

The technical scheme adopted by the application is as follows: provided is a blood analyzer including:

a mode selection module for selecting a detection mode from a plurality of detection modes of the blood analyzer, the plurality of detection modes including a specific protein individual detection mode;

the blood routine detection module is used for performing blood routine detection on the whole blood sample;

the specific protein detection module is used for carrying out specific protein detection on the whole blood sample;

a control module for controlling the specific protein detection module to perform detection when the mode selection module selects the specific protein individual detection mode;

and when the control module judges that the detection times of the specific protein detection module are integral multiples of the preset times, the control module is used for cleaning the reaction tank corresponding to the blood routine detection module and the specific protein single detection mode by adopting a first cleaning mode.

The reaction tank corresponding to the blood routine detection module and the specific protein single detection mode comprises a WBC reaction tank and an RBC reaction tank, and when the control module judges that the detection times of the specific protein detection module are integral multiples of the preset times, the control module adopts a first cleaning mode to clean the WBC reaction tank and/or the RBC reaction tank.

Wherein the plurality of detection modes includes a detection mode of a blood-based routine detection, and the control module cleans the WBC reaction cell and/or the RBC reaction cell using the first cleaning mode when the mode selection module switches the specific protein individual detection mode to the detection mode of the blood-based routine detection.

Wherein the preset number of times is 1, and the control module is configured to clean the WBC reaction tank and/or the RBC reaction tank using the first cleaning mode after each detection is completed.

Wherein, the preset number is greater than 1, and when the control module determines that the detection number is not an integral multiple of the preset number, the control module is configured to clean the WBC reaction tank and/or the RBC reaction tank in a second cleaning mode.

Wherein, when the control module cleans the WBC reaction tank and/or the RBC reaction tank in the first cleaning mode, the jewel hole of the WBC reaction tank and/or the jewel hole of the RBC reaction tank are/is burned and backflushed at least once; and/or, the WBC reaction cell and/or the RBC reaction cell are washed by a hemolytic agent.

Another technical scheme adopted by the application is as follows: the detection method of the blood analyzer is applied to the blood analyzer, and comprises the following steps:

the blood analyzer is provided with a plurality of detection modes, wherein the plurality of detection modes comprise a specific protein single detection mode;

the control module controls the specific protein detection module to perform detection when the mode selection module selects the specific protein individual detection mode;

the control module judges whether the detection times of the specific protein detection module are integral multiples of preset times or not;

and when the control module judges that the detection times are integral multiples of the preset times, the control module adopts a first cleaning mode to clean the reaction tank corresponding to the specific protein single detection mode.

Wherein the reaction cell of the blood routine detection module corresponding to the specific protein individual detection mode comprises a WBC reaction cell and a RBC reaction cell, the plurality of detection modes comprise a detection mode of blood routine detection, and the detection method further comprises:

the control module cleans the WBC reaction cell and/or the RBC reaction cell in the first cleaning mode when the mode selection module switches the specific protein-alone detection mode to the detection mode of the blood-containing conventional detection.

Wherein the preset times is 1, and the step of cleaning the reaction cell corresponding to the specific protein single detection mode by the control module comprises the following steps:

the control module purges the WBC reaction cell and/or the RBC reaction cell in the first purging mode each time a test is completed.

The step of judging whether the detection times are integral multiples of the preset times by the control module includes:

and when the control module judges that the detection times are not integral multiples of the preset times, the control module adopts a second cleaning mode to clean the WBC reaction tank and/or the RBC reaction tank.

The step of cleaning the reaction cell corresponding to the blood routine detection module and the specific protein single detection mode by the control module by adopting a first cleaning mode comprises the following steps:

at least one burning and backflushing is carried out on the gem hole of the WBC reaction pool and/or the gem hole of the RBC reaction pool;

and/or, the WBC reaction cell and/or the RBC reaction cell are washed by a hemolytic agent.

Wherein the step of controlling the specific protein detection module to perform detection by the control module comprises:

the control module controls a sampling module of the blood analyzer to suck a whole blood sample and distribute the whole blood sample to a specific protein reaction pool of the specific protein detection module;

the control module adds a reagent into the specific protein reaction tank and detects the reagent to obtain a detection result;

the control module controls the sampling module to dispense the whole blood sample to the WBC reaction cell to dilute the whole blood sample;

the control module controls the sampling module to add a portion of the diluted sample of the WBC reaction cell to the RBC reaction cell of the blood routine detection module to calculate an HCT value;

the control module corrects the detection result based on the HCT value.

The blood analyzer comprises a mode selection module, a blood routine detection module, a specific protein detection module and a control module, wherein the mode selection module is used for selecting one detection mode from a plurality of detection modes of the blood analyzer; the control module is used for controlling the specific protein detection module to carry out detection when the mode selection module selects the specific protein individual detection mode; and when the control module judges that the detection times of the specific protein detection module are integral multiples of the preset times, the control module is used for cleaning the reaction tank corresponding to the blood routine detection module and the specific protein single detection mode by adopting a first cleaning mode. When the blood analyzer is in the independent detection mode of the specific protein, the detection times of the specific protein detection module are integral multiples of the preset times, the first cleaning mode is adopted for cleaning the conventional blood detection module and the reaction tank corresponding to the independent detection mode of the specific protein, and the conventional blood detection module and the reaction tank corresponding to the independent detection mode of the specific protein can be blocked so as to prevent the occurrence of hole blockage and improve the detection accuracy of the blood analyzer, so that the use of a user is facilitated.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the description below are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts. Wherein:

fig. 1 is a schematic configuration diagram of a first embodiment of a blood analyzer of the present application;

FIG. 2 is a schematic flow diagram of a first embodiment of a detection method of the blood analyzer of the present application;

FIG. 3 is a schematic flow diagram of a second embodiment of a detection method of the blood analyzer of the present application;

fig. 4 is a flowchart of a first embodiment of step S202 in fig. 2.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are merely illustrative of the application and are not limiting of the application. It should be further noted that, for the convenience of description, only some of the structures related to the present application are shown in the drawings, not all of the structures. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.

The terms "first", "second", etc. in this application are used to distinguish between different objects and not to describe a particular order. Furthermore, the terms "include" and "have," as well as any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements but may alternatively include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.

Referring to fig. 1, fig. 1 is a schematic structural diagram of a first embodiment of a blood analyzer of the present application. The blood analyzer 10 of the present application includes a mode selection module 11, a specific protein detection module 12, a blood routine detection module 13, and a control module 14.

The specific protein detection module 12 is used for performing specific protein detection on the whole blood sample, and the blood routine detection module 13 is used for performing blood routine detection on the whole blood sample; the control module 14 may be connected to the mode selection module 11, the specific protein detection module 12 and the blood routine detection module 13, respectively. In other embodiments, the specific protein detection module 12 may perform detection on other blood samples, such as serum samples, and the like.

Among them, conventional Blood tests include WBC (White Blood Cell) test, HGB (Hemoglobin) test, RBC (red Blood Cell) test, DIFF (differential, leukocyte five classification) test, or RET (reticulocyte) test. The specific protein includes one of SAA, CRP, TRF (transferrin ), hs-CRP (hypersensitive C-reactive protein), PCT (procalcitonin), and D-Dimer (D-Dimer).

In one embodiment, the hematology analyzer 10 can include at least two specific protein detection modules 12, for example, at least two specific protein detection modules 12 include a SAA detection module and a CRP detection module, i.e., the hematology analyzer 10 is a blood routine, SAA, and CRP integrated machine.

The mode selection module 11 is configured to select one detection mode from a plurality of detection modes of the blood analyzer 10. Optionally, the mode selection module 11 is also used to preset a plurality of detection modes of the blood analyzer 10.

Specifically, the plurality of detection modes of the blood analyzer 10 include a specific protein individual detection mode; the single specific protein detection mode refers to a mode in which only specific protein parameters and HCT (Hematocrit value) detection results (i.e., HCT values) are output, and may be an SAA single detection mode, a CRP single detection mode, an SAA + CRP single detection mode, a TRF single detection mode, an Hs-CRP single detection mode, a PCT single detection mode, or a D-Dimer single detection mode. For example, the plurality of detection modes of the hematology analyzer 10 include a SAA-only detection mode, a CRP-only detection mode, or a SAA + CRP-only detection mode.

When the mode selection module 11 selects the specific protein individual detection mode, the specific protein detection module 12 corresponding to the specific protein individual detection mode in the blood analyzer 10 performs detection, that is, the control module 14 is configured to control the specific protein detection module 12 to perform detection. For example, if the mode selection module 11 selects the SAA-only detection mode, the control module 14 is used to control the specific protein detection module 12 (e.g., SAA detection module) corresponding to the SAA-only detection mode to perform detection on the whole blood sample; or, the mode selection module 11 selects the CRP single-detection mode, the control module 14 is configured to control the specific protein detection module 12 (e.g., CRP detection module) corresponding to the CRP single-detection mode to perform the detection on the whole blood sample; still alternatively, the mode selection module 11 selects the SAA + CRP single-assay mode, and the control module 14 is configured to control the specific protein assay module 13 (such as the SAA assay module and the CRP assay module) corresponding to the SAA + CRP single-assay mode to perform the assay on the whole blood sample.

When the specific protein detection module 12 performs detection, the control module 14 may count the number of times that the specific protein detection module 12 performs detection in the specific protein individual detection mode, so as to obtain the number of times that the specific protein detection module 12 performs detection. The control module 14 is used for comparing the detection times of the specific protein detection module 12 with preset times and judging whether the detection times are integral multiples of the preset times; when the control module 14 determines that the detection times of the specific protein detection module 12 are integral multiples of the preset times, the control module 14 is configured to clean the reaction cell corresponding to the blood routine detection module 13 and the specific protein single detection mode by using the first cleaning mode. Wherein the integer multiple is a positive integer greater than 0, for example, the integer multiple is 1, 2, 3, 4, 5, or 6, etc.

The reaction pool of the blood routine detection module 13 corresponding to the specific protein individual detection mode includes a WBC reaction pool 131 and an RBC reaction pool 132, and when the control module 14 determines that the detection frequency of the specific protein detection module 12 is an integral multiple of the preset frequency, the control module 14 cleans the WBC reaction pool 131 and/or the RBC reaction pool 132 in the first cleaning mode.

In one embodiment, the control module 14 employs the first cleaning mode to clean the WBC reaction tank 131, so as to remove blockage from the WBC reaction tank 131, prevent the WBC reaction tank 131 from being clogged, and improve the detection accuracy of the blood analyzer.

For example, when the control module 14 determines that the number of times of detection of the specific protein detection module 12 is an integer multiple of the preset number of times, the control module 14 performs cleaning on the WBC reaction tank 131 by using the first cleaning mode to remove the blockage from the WBC reaction tank 131. Among them, the blood analyzer 10 uses the WBC reaction cell 131 as a dilution cell of the whole blood sample in the CRP-only detection mode, resulting in the WBC reaction cell 131 being prone to clogging; therefore, when the control module 14 determines that the detection frequency of the specific protein detection module 12 is an integral multiple of the preset frequency, the control module 14 needs to clean the WBC reaction tank 131 by using the first cleaning mode to drain the WBC reaction tank 131.

In an embodiment, the control module 14 employs the first cleaning mode to clean the RBC reaction tank 132, so as to remove blockage from the RBC reaction tank 132, thereby ensuring accuracy of the HCT value and improving detection accuracy of the blood analyzer.

In an embodiment, the control module 14 employs the first cleaning mode to clean the WBC reaction tank 131 and the RBC reaction tank 132, so as to block the WBC reaction tank 131 and the RBC reaction tank 132, prevent the WBC reaction tank 131 from being blocked, ensure accuracy of the HCT value, and improve detection accuracy of the blood analyzer, so that a user can use the blood analyzer conveniently.

In this embodiment, when the control module 14 determines that the detection frequency of the specific protein detection module 12 is an integral multiple of the preset frequency, the control module 14 adopts the first cleaning mode to clean the blood routine detection module 13 and the reaction cell corresponding to the specific protein individual detection mode, and can remove blockage from the reaction cell corresponding to the blood routine detection module and the specific protein individual detection mode, so as to prevent hole blockage, improve the detection accuracy of the blood analyzer, and facilitate the use of a user.

For example, when the mode selection module 11 selects the single specific protein detection mode as the single CRP detection mode, the single specific protein detection module 12 performs CRP detection on the whole blood sample.

Optionally, the blood analyzer 10 of the present application may be provided with a sample injection mode, which represents a manner in which the blood analyzer 10 aspirates a whole blood sample within a test tube, the sample injection mode including an auto sample injection mode and an open sample injection mode. When blood analyzer 10 is in the autoinjection mode, the injector propelling movement test tube of blood analyzer 10 to inhale the whole blood sample in the test tube in blood analyzer 10, for example the user sets up the test-tube rack on blood analyzer 10, and blood analyzer 10 can detect the whole blood sample of a plurality of test tubes on the test-tube rack in succession. When the blood analyzer 10 is in the open sample mode, the user places the test tube under the sampling needle of the blood analyzer 10, and the blood analyzer 10 performs a suction test on the whole blood sample of the test tube.

As shown in fig. 1, the blood analyzer 10 further includes a sampling module 15 coupled to the control module 14, the sampling module 15 being configured to collect a whole blood sample and distribute the whole blood sample to the specific protein detection module 12. As described in detail below, when the mode selection module 11 selects the specific protein single detection mode, the step of detecting the whole blood sample by the specific protein detection module 12 includes:

the control module 14 controls the sampling module 15 of the blood analyzer 10 to draw a whole blood sample and distribute the whole blood sample to the specific protein reaction cell 121 of the specific protein detection module 12. Wherein the control module 14 controls the sampling module 15 to move to the test tube to draw the whole blood sample from the test tube; the control module 14 controls the sampling module 15 to move to the specific protein reaction cell 121 to distribute the whole blood sample to the specific protein reaction cell 121; the control module 14 controls the sampling module 15 to perform cleaning.

The control module 14 adds a reagent to the specific protein reaction tank 121 and performs detection to obtain a detection result, where the detection result includes specific protein parameters. Wherein, the control module 14 can control the sampling module 15 to suck the reagent and inject the reagent into the specific protein reaction tank 121; the control module 14 controls the sampling module 15 to perform cleaning. The whole blood sample and the reagent in the specific protein reaction cell 121 are mixed and reacted, and the blood analyzer 10 detects the liquid in the specific protein reaction cell 121 to obtain a detection result.

The control module 14 controls the sampling module 15 to dispense the whole blood sample to the WBC reaction cell 131 to dilute the whole blood sample. The control module 14 may control the sampling module 15 to dispense the whole blood sample to the WBC reaction cell 131 when the whole blood sample is dispensed to the specific protein reaction cell 121, and the WBC reaction cell 131 is used for performing a primary dilution of the whole blood sample, so as to obtain a diluted sample of the WBC reaction cell 131.

The control module 14 controls the sampling module 15 to add a portion of the diluted sample of the WBC reaction cell 131 to the RBC reaction cell 132 of the blood routine detection module 13 to calculate the HCT value. After the sampling module 15 adds a part of the diluted sample of the WBC reaction cell 131 to the RBC reaction cell 132, the RBC reaction cell 132 performs a second dilution on the diluted sample, and the blood analyzer 10 detects the liquid in the RBC reaction cell 132 to obtain the HCT value.

The control module 14 corrects the detection result based on the HCT value, wherein the control module 14 corrects the detection result by using the HCT value, so that the corrected detection result is more accurate.

When the control module 14 judges that the detection times are integral multiples of the preset times, the blood analyzer 10 adopts the first cleaning mode to clean the WBC reaction pool 131 and/or the RBC reaction pool 132 of the conventional blood detection module 13, and can remove blockage of the WBC reaction pool 131 and/or the RBC reaction pool 132, so as to prevent the WBC reaction pool 131 and/or the RBC reaction pool 132 from blocking holes, ensure the accuracy of the HCT value, ensure that the blood analyzer 10 can normally work, and improve the detection accuracy of the blood analyzer 10.

In one embodiment, when the control module 14 cleans the WBC reaction cell 131 and/or the RBC reaction cell 132 in the first cleaning mode, the jewel hole of the WBC reaction cell 131 and/or the jewel hole of the RBC reaction cell 132 are burned and backflushed at least once, for example, the jewel hole of the WBC reaction cell 131 and/or the jewel hole of the RBC reaction cell 132 are burned and backflushed multiple times, so as to drain the jewel hole of the WBC reaction cell 131 and/or the jewel hole of the RBC reaction cell 132.

In one embodiment, when the control module 14 performs the cleaning of the WBC reaction tank 131 and/or the RBC reaction tank 132 in the first cleaning mode, the WBC reaction tank 131 and/or the RBC reaction tank 132 are cleaned by a hemolytic agent, for example, the WBC reaction tank 131 and/or the RBC reaction tank 132 are cleaned by an R1 reagent, so as to block the jewel holes of the WBC reaction tank 131 and/or the RBC reaction tank 132.

In other embodiments, the WBC reaction cell 131 and/or the RBC reaction cell 132 may be washed by a hemolytic agent, and the gem hole of the WBC reaction cell 131 and/or the gem hole of the RBC reaction cell 132 may be burned and backflushed at least once to drain the WBC reaction cell 131 and/or the RBC reaction cell 132, so as to improve the draining effect of the WBC reaction cell 131 and/or the RBC reaction cell 132.

In one embodiment, the plurality of detection modes of the blood analyzer 10 include a specific protein individual detection mode and a blood-containing routine detection mode, which indicates that the output result includes a measurement mode of the total number of white blood cells, red blood cells, platelets, hemoglobin, or the like. For example: the detection mode of the conventional blood-containing detection is a CBC (complete count) + Diff + CRP detection mode, a CBC + Diff + SAA + CRP detection mode, a CBC + SAA detection mode, a CBC + CRP detection mode, or a CBC + CRP + SAA detection mode.

When the mode selection module 11 switches the mode of detection of a specific protein alone to the detection mode of a routine blood-containing detection, the control module 14 performs a first cleaning mode for cleaning the WBC reaction cell 131 and/or the RBC reaction cell 132. For example, when the mode selection module 11 switches the CRP-alone testing mode to the blood-routine testing mode, the control module 14 cleans the WBC reaction pool 131 and/or the RBC reaction pool 132 using the first cleaning mode to drain the WBC reaction pool 131 and/or the RBC reaction pool 132.

In an embodiment, the preset number is 1, and when the control module 14 determines that the detection number is an integer multiple of the preset number, the control module 14 is configured to clean the WBC reaction tank 131 and/or the RBC reaction tank 132 in the first cleaning mode. Since the detection times are any positive integers which are integer multiples of the preset times, the control module 14 is configured to clean the WBC reaction tank 131 and/or the RBC reaction tank 132 in the first cleaning mode each time the detection is completed, that is, the control module 14 cleans the WBC reaction tank 131 and/or the RBC reaction tank 132 in the first cleaning mode each time the detection of the specific protein detection module 12 is completed.

In an embodiment, the preset number is greater than 1, and when the control module 14 determines that the detection number is not an integral multiple of the preset number, the control module 14 is configured to clean the WBC reaction tank 131 and/or the RBC reaction tank 132 by using the second cleaning mode. For example, if the preset number is 3, and the control module 14 counts that the number of detection times of the specific protein detection module 12 is 2, the control module 14 determines that the number of detection times is not an integral multiple of the preset number, and then performs cleaning on the WBC reaction tank 131 and/or the RBC reaction tank 132 by using the second cleaning mode.

When the control module 14 is configured to clean the WBC reaction cell 131 and/or the RBC reaction cell 132 in the second cleaning mode, the WBC reaction cell 131 and/or the RBC reaction cell 132 may be cleaned by the diluent to prevent the plurality of whole blood samples from contaminating each other in the WBC reaction cell 131 and/or the RBC reaction cell 132.

When the blood analyzer 10 of this embodiment is in the specific protein individual detection mode, and the detection times of the specific protein detection module 12 are integer multiples of the preset times, the control module 14 is configured to clean the WBC reaction tank 131 and/or the RBC reaction tank 132 by using the first cleaning mode, and can drain the WBC reaction tank 131 and/or the RBC reaction tank 132, so as to prevent the WBC reaction tank 131 and/or the RBC reaction tank 132 from being plugged, and improve the detection accuracy of the blood analyzer 10.

Referring to fig. 2, fig. 2 is a schematic flow chart of a first embodiment of a detection method of the blood analyzer of the present application. The detection method of the present embodiment is applied to the above-described blood analyzer 10, and includes the steps of:

s201: the blood analyzer 10 is provided with a plurality of detection modes including a specific protein individual detection mode.

The multiple detection modes of the blood analyzer 10 include a specific protein single detection mode, where the specific protein single detection mode indicates a mode in which only specific protein parameters and HCT detection results are output, and the specific protein single detection mode may be an SAA single detection mode, a CRP single detection mode, an SAA + CRP single detection mode, a TRF single detection mode, an Hs-CRP single detection mode, a PCT single detection mode, or a D-Dimer single detection mode.

S202: when the mode selection module 11 selects the specific protein individual detection mode, the control module 14 controls the specific protein detection module 12 to perform detection.

When the mode selection module 11 selects the specific protein individual detection mode, the specific protein detection module 12 corresponding to the specific protein individual detection mode in the blood analyzer 10 performs detection, that is, the control module 14 is configured to control the specific protein detection module 12 to perform detection. For example, if the mode selection module 11 selects the CRP-only detection mode, the control module 14 is used to control the detection module 12 (e.g., CRP detection module) corresponding to the CRP-only detection mode to detect the whole blood sample.

S203: the control module 14 determines whether the number of times of detection by the specific protein detection module 12 is an integer multiple of the preset number of times.

When the specific protein detection module 12 performs detection, the control module 14 may count the number of times that the specific protein detection module 12 performs detection in the specific protein individual detection mode, so as to obtain the number of times that the specific protein detection module 12 performs detection. The control module 14 is configured to compare the detection times of the specific protein detection module 12 with the preset times, and determine whether the detection times are integer multiples of the preset times. If yes, go to step S204; if not, the process proceeds to step S205.

S204: when the control module 14 determines that the detection times are integral multiples of the preset times, the control module 14 adopts a first cleaning mode to clean the reaction cell corresponding to the blood routine detection module 13 and the specific protein single detection mode.

In one embodiment, the control module 14 employs the first cleaning mode to clean the WBC reaction chamber 131, so as to remove the blockage of the WBC reaction chamber 131, prevent the WBC reaction chamber 131 from being clogged, and improve the detection accuracy of the blood analyzer.

In one embodiment, the control module 14 performs a first cleaning mode to clean the WBC reaction tank 131 and the RBC reaction tank 132, so as to drain the WBC reaction tank 131 and the RBC reaction tank 132, prevent that WBC reaction tank 131 from appearing stifled hole, and guarantee the degree of accuracy of HCT value, improve blood analyzer's detection rate of accuracy to make user facilitate the use.

S205: when the control module 14 determines that the detection times are not integral multiples of the preset times, the control module 14 uses a second cleaning mode to clean the reaction cell of the blood routine detection module 13 corresponding to the specific protein individual detection mode.

When the blood analyzer 10 of this embodiment is in the specific protein individual detection mode, and the detection frequency of the specific protein detection module 12 is an integral multiple of the preset frequency, the control module 14 is configured to clean the WBC reaction tank 131 and/or the RBC reaction tank 132 by using the first cleaning mode, and can drain the WBC reaction tank 131 and/or the RBC reaction tank 132, so as to prevent the WBC reaction tank 131 and/or the RBC reaction tank 132 from being plugged, and improve the detection accuracy of the blood analyzer 10.

In step S204, the preset number of times is 1, and when the control module 14 determines that the detection number of times is an integral multiple of the preset number of times, the control module 14 is configured to clean the WBC reaction tank 131 and/or the RBC reaction tank 132 by using the first cleaning mode. Since the detection times are any positive integers which are integer multiples of the preset times, the control module 14 is configured to clean the WBC reaction tank 131 and/or the RBC reaction tank 132 in the first cleaning mode each time the detection is completed, that is, the control module 14 cleans the WBC reaction tank 131 and/or the RBC reaction tank 132 in the first cleaning mode each time the detection of the specific protein detection module 12 is completed.

In step S205, the preset number is greater than 1, and when the control module 14 determines that the detection number is not an integral multiple of the preset number, the control module 14 is configured to clean the WBC reaction tank 131 and/or the RBC reaction tank 132 by using the second cleaning mode. For example, if the preset number is 3, and the control module 14 counts that the number of detection times of the specific protein detection module 12 is 2, the control module 14 determines that the number of detection times is not an integral multiple of the preset number, and then performs cleaning on the WBC reaction tank 131 and/or the RBC reaction tank 132 by using the second cleaning mode.

Referring to fig. 3, fig. 3 is a schematic flow chart of a detection method of the blood analyzer of the present application according to a second embodiment. The detection method of the embodiment comprises the following steps:

s301: the blood analyzer 10 is provided with a plurality of detection modes including a specific protein individual detection mode.

S302: when the mode selection module 11 selects the specific protein individual detection mode, the control module 14 controls the specific protein detection module 12 to perform detection.

S303: the control module 14 determines whether the number of times of detection by the specific protein detection module 12 is an integer multiple of the preset number of times.

S304: when the control module 14 determines that the detection times are integral multiples of the preset times, the control module 14 adopts a first cleaning mode to clean the reaction cell corresponding to the blood routine detection module 13 and the specific protein single detection mode.

S305: when the control module 14 determines that the detection times are not integral multiples of the preset times, the control module 14 uses a second cleaning mode to clean the reaction cell of the blood routine detection module 13 corresponding to the specific protein individual detection mode.

Steps S301 to S305 are the same as steps S201 to S205, and are not described herein again.

S306: when the mode selection module 11 switches the specific protein individual detection mode to the detection mode of the blood-containing routine detection, the control module 14 adopts the first cleaning mode to clean the reaction cells of the blood routine detection module 13 corresponding to the specific protein individual detection mode.

When the mode selection module 11 switches the specific protein individual detection mode to the detection mode of the blood-containing conventional detection, the control module 14 performs cleaning of the WBC reaction cell 131 and/or the RBC reaction cell 132 using the first cleaning mode. For example, when the mode selection module 11 switches the CRP individual detection mode to the blood routine detection mode, the control module 14 cleans the WBC reaction cell 131 and/or the RBC reaction cell 132 using the first cleaning mode to drain the WBC reaction cell 131 and/or the RBC reaction cell 132.

Referring to fig. 4, fig. 4 is a schematic flowchart of a first embodiment of step S202 in fig. 2. Step S202 includes the steps of:

s401: the control module 14 controls the sampling module 15 of the blood analyzer 10 to draw a whole blood sample and distribute the whole blood sample to the specific protein reaction cell 121 of the specific protein detection module 12.

The control module 14 controls the sampling module 15 to move to the test tube to draw the whole blood sample from the test tube; the control module 14 controls the sampling module 15 to move to the specific protein reaction cell 121 to distribute the whole blood sample to the specific protein reaction cell 121; the control module 14 controls the sampling module 15 to perform cleaning.

S402: the control module 14 adds a reagent to the specific protein reaction tank 121 and performs detection to obtain a detection result.

The control module 14 can control the sampling module 15 to suck the reagent and inject the reagent into the specific protein reaction tank 121; the control module 14 controls the sampling module 15 to perform cleaning. The whole blood sample and the reagent in the specific protein reaction cell 121 are mixed and reacted, and the blood analyzer 10 detects the liquid in the specific protein reaction cell 121 to obtain a detection result.

S403: the control module 14 controls the sampling module 15 to dispense the whole blood sample to the WBC reaction cell 131 to dilute the whole blood sample.

The control module 14 may control the sampling module 15 to dispense the whole blood sample to the WBC reaction cell 131 when the whole blood sample is dispensed to the specific protein reaction cell 121, and the WBC reaction cell 131 is used for performing a dilution of the whole blood sample to obtain a diluted sample of the WBC reaction cell 131.

S404: the control module 14 controls the sampling module 15 to add a portion of the diluted sample of the WBC reaction cell 131 to the RBC reaction cell 132 of the blood routine detection module 13 to calculate the HCT value.

After the sample module 15 adds the diluted sample of the WBC reaction tank 131 to the RBC reaction tank 132, the RBC reaction tank 132 performs a second dilution on the diluted sample, and the blood analyzer 10 detects the liquid in the RBC reaction tank 132 to obtain the HCT value.

S405: the control module 14 corrects the detection result based on the HCT value.

The control module 14 corrects the detection result by using the HCT value, so that the corrected detection result is more accurate.

In the several embodiments provided in the present application, it should be understood that the disclosed apparatus may be implemented in other manners. For example, the above-described device embodiments are merely illustrative, and the division of the modules or units is only one logical division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed.

The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the embodiment.

In addition, functional units in the embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units may be integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.

The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made according to the content of the present specification and the accompanying drawings, or which are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.

Claims

1. A blood analyzer, comprising:

a mode selection module for selecting a detection mode from a plurality of detection modes of the hematology analyzer, the plurality of detection modes including a specific protein individual detection mode;

2. The blood analyzer of claim 1, wherein the reaction cells of the blood routine detection module corresponding to the individual detection mode of the specific protein comprise a WBC reaction cell and an RBC reaction cell, and when the control module determines that the detection times of the specific protein detection module are integer multiples of a preset number, the control module cleans the WBC reaction cell and/or the RBC reaction cell by using a first cleaning mode.

3. The hematology analyzer of claim 2, wherein the plurality of detection modes includes a detection mode of a blood-based routine detection, and the control module purges the WBC reaction cell and/or the RBC reaction cell in the first purging mode when the mode selection module switches the specific protein alone detection mode to the detection mode of the blood-based routine detection.

4. The hematology analyzer of claim 2, wherein the preset number of times is 1, and the control module is configured to clean the WBC reaction cell and/or the RBC reaction cell using the first cleaning mode at each completion of the test.

5. The blood analyzer of claim 2, wherein the predetermined number is greater than 1, and when the control module determines that the detection number is not an integer multiple of the predetermined number, the control module is configured to clean the WBC reaction cell and/or the RBC reaction cell using a second cleaning mode.

6. The hematology analyzer of any one of claims 1-5, wherein the gem hole of the WBC reaction cell and/or the gem hole of the RBC reaction cell are/is burned and backflushed at least once when the control module cleans the WBC reaction cell and/or the RBC reaction cell in the first cleaning mode; and/or, the WBC reaction cell and/or the RBC reaction cell are washed by a hemolytic agent.

7. A detection method of a blood analyzer, which is applied to the blood analyzer according to any one of claims 1 to 6, the detection method comprising:

and when the control module judges that the detection times are integral multiples of the preset times, the control module cleans the reaction tank corresponding to the specific protein single detection mode.

8. The detection method according to claim 7, wherein the reaction cell of the blood routine detection module corresponding to the specific protein individual detection mode comprises a WBC reaction cell and a RBC reaction cell, and the plurality of detection modes comprises a detection mode including blood routine detection, and the detection method further comprises:

9. The method according to claim 7, wherein the predetermined number of times is 1, and the step of washing the reaction cell corresponding to the specific protein single detection mode by the control module comprises:

10. The detecting method according to claim 7, wherein the preset number is greater than 1, and the step of the control module determining whether the number of detections is an integer multiple of the preset number comprises:

11. The detection method according to any one of claims 8 to 10, wherein the step of washing the reaction cell of the blood routine detection module corresponding to the specific protein individual detection mode by the control module using the first washing mode comprises:

12. The assay of any one of claims 8-10, wherein the step of the control module controlling the specific protein assay module to perform the assay comprises:

the control module corrects the detection result based on the HCT value.