CN115518088A - Auditory canal cleaning fluid and preparation method thereof - Google Patents
Auditory canal cleaning fluid and preparation method thereof Download PDFInfo
- Publication number
- CN115518088A CN115518088A CN202110627398.1A CN202110627398A CN115518088A CN 115518088 A CN115518088 A CN 115518088A CN 202110627398 A CN202110627398 A CN 202110627398A CN 115518088 A CN115518088 A CN 115518088A
- Authority
- CN
- China
- Prior art keywords
- parts
- auditory canal
- purified water
- cleaning solution
- canal cleaning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004140 cleaning Methods 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000012530 fluid Substances 0.000 title description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 76
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000008213 purified water Substances 0.000 claims abstract description 38
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 37
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 27
- 239000008158 vegetable oil Substances 0.000 claims abstract description 27
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 26
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 26
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 26
- 239000003899 bactericide agent Substances 0.000 claims abstract description 26
- 229940059904 light mineral oil Drugs 0.000 claims abstract description 26
- 239000004166 Lanolin Substances 0.000 claims abstract description 20
- 229940039717 lanolin Drugs 0.000 claims abstract description 20
- 235000019388 lanolin Nutrition 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 19
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000003756 stirring Methods 0.000 claims description 40
- 239000011259 mixed solution Substances 0.000 claims description 35
- 239000000243 solution Substances 0.000 claims description 35
- 210000000613 ear canal Anatomy 0.000 claims description 29
- 235000006708 antioxidants Nutrition 0.000 claims description 25
- 238000005303 weighing Methods 0.000 claims description 20
- 238000010438 heat treatment Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- 238000003303 reheating Methods 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 2
- 235000021466 carotenoid Nutrition 0.000 claims description 2
- 150000001747 carotenoids Chemical class 0.000 claims description 2
- 239000000686 essence Substances 0.000 claims description 2
- 235000019155 vitamin A Nutrition 0.000 claims description 2
- 239000011719 vitamin A Substances 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 229940045997 vitamin a Drugs 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 abstract description 22
- 208000024891 symptom Diseases 0.000 abstract description 4
- 206010011878 Deafness Diseases 0.000 abstract description 3
- 208000009205 Tinnitus Diseases 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 231100000888 hearing loss Toxicity 0.000 abstract description 3
- 230000010370 hearing loss Effects 0.000 abstract description 3
- 208000016354 hearing loss disease Diseases 0.000 abstract description 3
- 231100000886 tinnitus Toxicity 0.000 abstract description 3
- 206010014020 Ear pain Diseases 0.000 abstract description 2
- 206010033078 Otitis media Diseases 0.000 abstract description 2
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- 208000024035 chronic otitis media Diseases 0.000 abstract description 2
- 208000007176 earache Diseases 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 206010014025 Ear swelling Diseases 0.000 abstract 1
- 208000032625 disorder of ear Diseases 0.000 abstract 1
- 210000002939 cerumen Anatomy 0.000 description 15
- 206010050337 Cerumen impaction Diseases 0.000 description 13
- 210000003454 tympanic membrane Anatomy 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 230000028327 secretion Effects 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 230000007794 irritation Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000016621 Hearing disease Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000001755 vocal effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
- A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an auditory canal cleaning solution and a preparation method thereof, belonging to the field of auditory canal cleaning solutions, wherein the auditory canal cleaning solution comprises the following raw materials in parts by weight: 10-20 parts of vegetable oil, 20-40 parts of glycerol, 15-30 parts of light mineral oil, 9-18 parts of lanolin, 2-5 parts of essence, 4-8 parts of a bactericide, 3-6 parts of an antioxidant, 7-29 parts of ethanol, 12-18 parts of hydrogen peroxide and 30-65 parts of purified water, wherein the main component of the bactericide is hexachlorodiphenylol methane or iodophor solution; can quickly and efficiently kill pathogenic bacteria in the auditory canal, effectively avoid infection in the auditory canal, control symptoms of chronic otitis media, and effectively prevent ear diseases such as tinnitus, earache, ear swelling, hearing loss, otitis media and the like; vegetable oil, glycerin and light mineral oil are selected for external use, and the external use is nourishing and moisturizing, and has small toxic and side effects.
Description
Technical Field
The invention relates to the field of auditory canal cleaning liquid, in particular to auditory canal cleaning liquid and a preparation method thereof.
Background
Earwax blocks up the disease that many the indicate earwax blocks up the duct and arouses, earwax is commonly known as earwax, the normal secretion of duct, many can deviate from by oneself, do not take place to block up and arouse the symptom, often be accompanied with the sense of stuffy plug of earwax, hearing declines, tinnitus, vertigo symptom, common disease has earwax embolism, the external auditory canal has self-cleaning's function, secretion in the external auditory canal can discharge automatically when chewing, so do not need the cleanness of carelessness, do not draw the ear at ordinary times as far as possible, keep the ear dry, avoid advancing water just, if draw the ear often, can destroy the environment in the duct, arouse that secretion increases in the ear, the ear larynx, even pain, the condition of hearing decline, if the ear endocrine is too much, need to reach the otorhinolaryngology branch of academic or vocational study and let the doctor clear up.
The ear canal is cleaned by carrying the object to the bedside, the patient is in a sitting position, the head is slightly deviated to the opposite side, the affected ear is slightly upward, a treatment towel or a rubber blanket is arranged around the neck and the shoulder of the same side, the bent disc of the hand support of the patient is tightly attached to the skin of the neck which is hung from the ear, so that water can flow back into the bent disc during washing, the auricle is pulled backwards and upwards by the left hand of an operator to enable the external ear canal to be in a straight line, the right hand holds the ear washing device, warm water is properly adjusted and injected into the back upper wall of the external ear canal, the force cannot be too strong, the head of the washing device cannot be tightly plugged into the external ear canal, so that the water cannot flow out to burst the eardrum, the eardrum cannot be directly impacted, the eardrum is prevented from being damaged, the external ear canal is wiped with a dry cotton swab after washing, the external ear canal and the eardrum are inspected to have no damage or lesion, and if the ear drum is treated in time.
In the above-mentioned operation process, if earwax once washes unclean, must continue to drip medicine, wash after the softening, traditional means is for dripping into hydrogen peroxide solution to duct, make earwax react with hydrogen peroxide and soften, nevertheless earwax reacts too strongly with the duct washing liquid, can cause the painful physiological reaction of duct stabbing, cause the hearing to decline, comparatively serious hearing disease more can cause the duct to excessively produce the secretion, breed the bacterium at the duct easily, cause to clear up the earwax repeatedly, it is great to the ear canal damage.
Disclosure of Invention
The invention aims to solve the technical problems that traditional auditory canal cleaning solution is large in irritation and prone to causing hearing loss, and provides auditory canal cleaning solution and a preparation method thereof, so that the problems are solved.
In order to achieve the purpose, the invention provides the following technical scheme: the ear canal cleaning solution comprises the following raw materials in parts by weight: 10-20 parts of vegetable oil, 20-40 parts of glycerol, 15-30 parts of light mineral oil, 9-18 parts of lanolin, 2-5 parts of essence, 4-8 parts of bactericide, 3-6 parts of antioxidant, 7-29 parts of ethanol, 12-18 parts of hydrogen peroxide and 30-65 parts of purified water, wherein the lanolin moistens and dries earwax deeply, which is beneficial to cleaning hard dirt of auditory canal, and the earwax is acted together with hydrogen peroxide with proper dose to soften, loosen, disintegrate and moderate in irritation; the vegetable oil, the glycerin and the light mineral oil play roles of sealing and moisturizing, a film can be formed in the auditory canal to prevent air from entering, the moisture of the skin is not easy to evaporate, the moisture in the air can be absorbed to moisten the skin, and the nourishing ingredients in the vegetable oil can penetrate into the cuticle layer of the epidermis to help to repair the skin at the bottom layer of the auditory canal; ethanol and purified water are used as solvents; the essence can alleviate odor.
Furthermore, the main component of the bactericide is hexachlorodiphenol methane or iodophor solution, wherein hexachlorodiphenol methane can be used as a baby oil sterilization raw material, has small toxic and side effects, and iodophor has broad-spectrum sterilization effect and can kill bacterial propagules, fungi, protozoa and partial viruses.
Further, the antioxidant is any one or a mixture of vitamin A, vitamin C, vitamin E and carotenoid, and the antioxidant is used for reducing cell oxidative damage.
A preparation method of an ear canal cleaning solution comprises the following preparation steps:
step 1: weighing excessive purified water and quantitative vegetable oil, glycerol and light mineral oil according to parts by weight, heating the purified water, pouring the vegetable oil, the glycerol and the light mineral oil into the purified water for mixing, wherein the mixing and stirring speed is 220-500 rad/min, the stirrer power is 1-5 KW, and the stirring time is 7-15 min until the purified water and the vegetable oil, the glycerol and the light mineral oil are completely dissolved to obtain a mixed solution A;
step 2: weighing lanolin, a bactericide and an antioxidant in a certain weight part ratio, adding the lanolin, the bactericide and the antioxidant into the mixed solution A, stirring, and reheating the mixed solution A, wherein the stirring speed is 100-500 rad/min, the stirrer power is 1-5 KW, and the stirring time is 15-30 min, so as to obtain a mixed solution B;
and step 3: and weighing the rest raw materials of essence, hydrogen peroxide and ethanol according to a certain weight part ratio, pouring the mixture into the mixed solution B, and stirring at the rotation speed of 100-500 rad/min and the stirrer power of 1-5 KW for 5-10 min to obtain the auditory canal cleaning liquid.
Furthermore, the heating temperature of the purified water in the step 1 is 75-85 ℃, and the temperature of the purified water is higher before the purified water is mixed with the vegetable oil, the glycerol and the light mineral oil.
Furthermore, the heating temperature of the mixed liquid A in the step 2 is between 45 ℃ and 55 ℃, and the raw material fusion is promoted for the second time.
Further, the mixing temperature of the raw material essence, the hydrogen peroxide, the ethanol and the mixed solution B in the step 3 is normal temperature, and the ethanol and the essence are mixed at the normal temperature to reduce the loss of the ethanol and the essence.
Further, the auditory canal cleaning solution prepared in the step 3 is packaged in a sealed container, the PH value of the auditory canal cleaning solution is 7.0-9.0, and the auditory canal cleaning solution is stored in a shade place.
Compared with the prior art, the invention has the following beneficial effects:
1. the ear canal cleaning solution and the preparation method thereof can soften, expand and remove earwax blocking the ear canal, dredge the ear canal, keep normal hearing, quickly clean foreign matters on the surface of the ear canal, keep the ear canal comfortable, and have mild raw materials and small irritation;
2. the auditory canal cleaning solution and the preparation method thereof can quickly and efficiently kill auditory canal pathogenic bacteria, effectively avoid infection in the auditory canal, control symptoms of chronic otitis media, and effectively prevent otopathy such as tinnitus, earache, ear distension, hearing loss, otitis media and the like;
3. the invention relates to an auditory canal cleaning fluid and a preparation method thereof.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the embodiment is an auditory canal cleaning solution which comprises the following raw materials in parts by weight: 12 parts of vegetable oil, 23 parts of glycerol, 15 parts of light mineral oil, 8 parts of lanolin, 2 parts of essence, 4 parts of bactericide, 4 parts of antioxidant, 20 parts of ethanol, 15 parts of hydrogen peroxide and 45 parts of purified water.
In this embodiment, the main component of the bactericide is selected from hexachlorodiphenol methane.
In this example, the antioxidant is vitamin E.
A preparation method of an ear canal cleaning fluid comprises the following preparation steps:
step 1: weighing excessive purified water and quantitative vegetable oil, glycerol and light mineral oil according to parts by weight, heating the purified water, pouring the vegetable oil, the glycerol and the light mineral oil into the purified water for mixing, and stirring at the mixing and stirring speed of 450rad/min and the stirrer power of 5KW for 15min until the purified water is completely dissolved to obtain a mixed solution A;
step 2: weighing lanolin, a bactericide and an antioxidant in parts by weight according to a certain proportion, adding the lanolin, the bactericide and the antioxidant into the mixed solution A, stirring, and reheating the mixed solution A, wherein the stirring speed is 300rad/min, the stirrer power is 5KW, and the stirring time is 30min to obtain a mixed solution B;
and step 3: and weighing the rest raw materials including the essence, the hydrogen peroxide and the ethanol according to a certain weight part ratio, pouring the mixture into the mixed solution B, and stirring at the stirring speed of 300rad/min and the stirrer power of 5KW for 10min to obtain the auditory canal cleaning solution.
In this example, the purified water in step 1 was heated at 80 ℃.
In this example, the heating temperature of mixture A in step 2 was 45 ℃.
In this embodiment, the mixing temperature of the raw material essence, the hydrogen peroxide, the ethanol and the mixed solution B in step 3 is normal temperature.
In this embodiment, the ear canal cleaning solution prepared in step 3 is enclosed in a sealed container.
Example 2 differs from example 1 in that:
the embodiment is an auditory canal cleaning solution which comprises the following raw materials in parts by weight: 18 parts of vegetable oil, 33 parts of glycerol, 24 parts of light mineral oil, 17 parts of lanolin, 2 parts of essence, 7 parts of bactericide, 4 parts of antioxidant, 20 parts of ethanol, 15 parts of hydrogen peroxide and 45 parts of purified water.
In this embodiment, the main component of the bactericide is selected from hexachlorodiphenol methane.
In this example, the antioxidant is vitamin E.
A preparation method of an ear canal cleaning solution comprises the following preparation steps:
step 1: weighing excessive purified water and quantitative vegetable oil, glycerol and light mineral oil according to parts by weight, heating the purified water, pouring the vegetable oil, the glycerol and the light mineral oil into the purified water for mixing, wherein the mixing and stirring speed is 450rad/min, the stirrer power is 5KW, and the stirring time is 15min until the vegetable oil, the glycerol and the light mineral oil are completely dissolved to obtain a mixed solution A;
step 2: weighing lanolin, a bactericide and an antioxidant in parts by weight according to a certain proportion, adding the lanolin, the bactericide and the antioxidant into the mixed solution A, stirring, and reheating the mixed solution A, wherein the stirring speed is 330rad/min, the stirrer power is 5KW, and the stirring time is 30min to obtain a mixed solution B;
and step 3: and weighing the rest raw materials including the essence, the hydrogen peroxide and the ethanol according to a certain weight part ratio, pouring the mixture into the mixed solution B, and stirring at the stirring speed of 330rad/min and the stirrer power of 5KW for 10min to obtain the auditory canal cleaning solution.
In this embodiment, the heating temperature of the purified water in step 1 is between 75 ℃ and 85 ℃.
In this embodiment, the heating temperature of the mixed solution a in the step 2 is between 45 ℃ and 55 ℃.
Example 3 differs from example 1 in that:
the embodiment is an auditory canal cleaning solution which comprises the following raw materials in parts by weight: 12 parts of vegetable oil, 23 parts of glycerol, 15 parts of light mineral oil, 17 parts of lanolin, 2 parts of essence, 7 parts of bactericide, 4 parts of antioxidant, 20 parts of ethanol, 15 parts of hydrogen peroxide and 45 parts of purified water.
In this embodiment, the main component of the bactericide is selected from hexachlorodiphenol methane.
In this example, the antioxidant is vitamin E.
A preparation method of an ear canal cleaning solution comprises the following preparation steps:
step 1: weighing excessive purified water and quantitative vegetable oil, glycerol and light mineral oil according to parts by weight, heating the purified water, pouring the vegetable oil, the glycerol and the light mineral oil into the purified water for mixing, wherein the mixing and stirring speed is 450rad/min, the stirrer power is 5KW, and the stirring time is 15min until the vegetable oil, the glycerol and the light mineral oil are completely dissolved to obtain a mixed solution A;
step 2: weighing lanolin, a bactericide and an antioxidant in parts by weight according to a certain proportion, adding the lanolin, the bactericide and the antioxidant into the mixed solution A, stirring, and reheating the mixed solution A, wherein the stirring speed is 330rad/min, the stirrer power is 5KW, and the stirring time is 27min to obtain a mixed solution B;
and step 3: and weighing the rest raw materials including the essence, the hydrogen peroxide and the ethanol according to a certain weight part ratio, pouring the mixture into the mixed solution B, and stirring at the stirring speed of 330rad/min and the stirrer power of 5KW for 10min to obtain the auditory canal cleaning solution.
In this example, the purified water in step 1 was heated at 80 ℃.
In this example, the heating temperature of mixture A in step 2 was 45 ℃.
Example 4, compared to example 1, differs in that:
the embodiment is an auditory canal cleaning solution which comprises the following raw materials in parts by weight: 10 parts of vegetable oil, 20 parts of glycerol, 15 parts of light mineral oil, 17 parts of lanolin, 2 parts of essence, 4 parts of bactericide, 4 parts of antioxidant, 19 parts of ethanol, 15 parts of hydrogen peroxide and 45 parts of purified water.
In this embodiment, the main component of the bactericide is selected from hexachlorodiphenol methane or iodophor solution.
In this example, the antioxidant is vitamin E.
A preparation method of an ear canal cleaning solution comprises the following preparation steps:
step 1: weighing excessive purified water and quantitative vegetable oil, glycerol and light mineral oil according to parts by weight, heating the purified water, pouring the vegetable oil, the glycerol and the light mineral oil into the purified water for mixing, and stirring at the mixing and stirring speed of 440rad/min and the stirrer power of 5KW for 15min until the purified water is completely dissolved to obtain a mixed solution A;
step 2: weighing lanolin, a bactericide and an antioxidant in parts by weight according to a certain proportion, adding the lanolin, the bactericide and the antioxidant into the mixed solution A, stirring, and reheating the mixed solution A, wherein the stirring speed is 300rad/min, the stirrer power is 5KW, and the stirring time is 30min to obtain a mixed solution B;
and step 3: and weighing the rest raw materials including the essence, the hydrogen peroxide and the ethanol according to a certain weight part ratio, pouring the mixture into the mixed solution B, and stirring at the stirring speed of 330rad/min and the stirrer power of 5KW for 10min to obtain the auditory canal cleaning solution.
In this example, the purified water in step 1 was heated at 82 ℃.
In this embodiment, the heating temperature of mixed liquor A in step 2 is between 45 ℃.
The ear canal cleansing liquids prepared in examples 1 to 4 were subjected to the following tests:
selecting 4 cases of severe patients, selecting common auditory canal cleaning liquid to clean auditory canals in sequence, using the auditory canal cleaning liquid prepared in embodiments 1-4 to wash the auditory canals in sequence in the first week, drying the washed objects, collecting cerumen agglomerates and weighing, recording as S1/S2/S3/S4, using the auditory canal cleaning liquid prepared in embodiments 1-4 to wash the auditory canals in sequence in the second week, drying the washed objects, collecting cerumen agglomerates and weighing, recording as N1/N2/N3/N4, calculating the N/S value of the patient using the auditory canal cleaning liquid in the same embodiment, wherein the test result is as follows:
| test group | Example 1 | Example 2 | Example 3 | Example 4 |
| Ratio of | 0.75 | 0.39 | 0.41 | 0.62 |
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. An ear canal wash solution, comprising: the auditory canal cleaning solution comprises the following raw materials in parts by weight: 10-20 parts of vegetable oil, 20-40 parts of glycerol, 15-30 parts of light mineral oil, 9-18 parts of lanolin, 2-5 parts of essence, 4-8 parts of bactericide, 3-6 parts of antioxidant, 7-29 parts of ethanol, 12-18 parts of hydrogen peroxide and 30-65 parts of purified water.
2. The cleaning solution for the auditory canal as claimed in claim 1, wherein the main component of the bactericide is selected from hexachlorodiphenolic methane or iodophor solution.
3. The ear canal cleaning solution as set forth in claim 1, wherein: the antioxidant is any one or mixture of vitamin A, vitamin C, vitamin E and carotenoid.
4. The preparation method of the auditory canal cleaning solution is characterized by comprising the following preparation steps:
step 1: weighing excessive purified water and quantitative vegetable oil, glycerol and light mineral oil according to parts by weight, heating the purified water, pouring the vegetable oil, the glycerol and the light mineral oil into the purified water for mixing, wherein the mixing and stirring speed is 220-500 rad/min, the stirrer power is 1-5 KW, and the stirring time is 7-15 min until the purified water and the vegetable oil, the glycerol and the light mineral oil are completely dissolved to obtain a mixed solution A;
and 2, step: weighing lanolin, a bactericide and an antioxidant in parts by weight according to a certain proportion, adding the lanolin, the bactericide and the antioxidant into the mixed solution A, stirring, and reheating the mixed solution A, wherein the stirring speed is 100-500 rad/min, the stirrer power is 1-5 KW, and the stirring time is 15-30 min to obtain a mixed solution B;
and step 3: and weighing the rest raw materials of essence, hydrogen peroxide and ethanol according to a certain weight part ratio, pouring the mixture into the mixed solution B, and stirring at the rotation speed of 100-500 rad/min and the stirrer power of 1-5 KW for 5-10 min to obtain the auditory canal cleaning liquid.
5. The method for preparing an ear canal cleaning solution as claimed in claim 4, wherein: the heating temperature of the purified water in the step 1 is between 75 and 85 ℃.
6. The method for preparing an ear canal cleaning solution as claimed in claim 4, wherein: the heating temperature of the mixed solution A in the step 2 is between 45 and 55 ℃.
7. The method for preparing an ear canal cleaning solution as defined in claim 4, wherein: and 3, mixing the raw material essence, the hydrogen peroxide, the ethanol and the mixed solution B at normal temperature.
8. The method for preparing an ear canal cleaning solution as claimed in claim 4, wherein: and (3) packaging the ear canal cleaning solution prepared in the step (3) in a sealed container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110627398.1A CN115518088A (en) | 2021-06-05 | 2021-06-05 | Auditory canal cleaning fluid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110627398.1A CN115518088A (en) | 2021-06-05 | 2021-06-05 | Auditory canal cleaning fluid and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115518088A true CN115518088A (en) | 2022-12-27 |
Family
ID=84693853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110627398.1A Pending CN115518088A (en) | 2021-06-05 | 2021-06-05 | Auditory canal cleaning fluid and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115518088A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013065051A1 (en) * | 2011-11-01 | 2013-05-10 | Naveh Pharma (1996) Ltd. | Formulation and device for treating ceruminosis |
| WO2013144895A1 (en) * | 2012-03-28 | 2013-10-03 | Terblanche Jacobus | Otic pharmaceutical composition |
| CN108042626A (en) * | 2017-12-22 | 2018-05-18 | 成都博创必成医药技术有限公司 | It is a kind of have to remove earwax and the composition of bacteriostasis efficacy, preparation and its application |
| CN111617104A (en) * | 2020-06-02 | 2020-09-04 | 福州安得尔卫生技术开发有限公司 | Ear canal cleaning and antibacterial spray |
-
2021
- 2021-06-05 CN CN202110627398.1A patent/CN115518088A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013065051A1 (en) * | 2011-11-01 | 2013-05-10 | Naveh Pharma (1996) Ltd. | Formulation and device for treating ceruminosis |
| WO2013144895A1 (en) * | 2012-03-28 | 2013-10-03 | Terblanche Jacobus | Otic pharmaceutical composition |
| CN108042626A (en) * | 2017-12-22 | 2018-05-18 | 成都博创必成医药技术有限公司 | It is a kind of have to remove earwax and the composition of bacteriostasis efficacy, preparation and its application |
| CN111617104A (en) * | 2020-06-02 | 2020-09-04 | 福州安得尔卫生技术开发有限公司 | Ear canal cleaning and antibacterial spray |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN115518088A (en) | Auditory canal cleaning fluid and preparation method thereof | |
| CN103142701A (en) | Ear dropping oil agent for mixed infection of pet ear canal and preparation method thereof | |
| CN107440925A (en) | A kind of compound method of disposable hand sanitizing fluid | |
| CN103222992A (en) | Sterilizing moist towelette and preparation method thereof | |
| CN105363062B (en) | Medical aquogel eye paste | |
| CN107929723A (en) | A kind of Chinese herbal medicine skin antiseptic | |
| CN104188848B (en) | Cooperatively used combined bag for cleaning and disinfecting skin after dog and animal injuries | |
| CN104435605A (en) | Preparation method of Chinese herbal medicine skin disinfectant | |
| CN215780942U (en) | Wound nursing degassing unit | |
| CN104825364A (en) | Baby wet wipe capable of easing prickly heat and stopping itching and preparation method | |
| CN116370357A (en) | A kind of plant source baby paper towel cream and preparation method thereof | |
| CN104434667A (en) | Chinese herbal medicine skin disinfectant wet wipe | |
| JP2004099527A (en) | Physiological salt solution with added polyphenol | |
| Sit et al. | Prophylactic intranasal mupirocin ointment in the treatment of peritonitis in continuous ambulatory peritoneal dialysis patients | |
| CN104306328A (en) | Polyhexamethylene guanidine auristilla | |
| CN104189946B (en) | Compound recipe Radix Sanguisorbae sponge preparation and preparation method | |
| CN112294865B (en) | A kind of traditional Chinese medicine preparation for treating suppurative otitis media and preparation method thereof | |
| CN109303718A (en) | A kind of pure traditional Chinese medicine compound wet wipes for preventing and treating baby red buttocks and preparation method thereof | |
| CN107744484A (en) | A kind of hand lotion and preparation method thereof | |
| CN203263637U (en) | Auditory meatus flusher | |
| CN107898366A (en) | A kind of disposable flushing-free nursing sleeve towel, conditioning liquid and set towel production method | |
| CN103948674A (en) | Nipple protection cream special for dairy cows as well as preparation method and application of nipple protection cream | |
| CN105380750A (en) | Making method for anti-bacterial non-woven fabric, anti-bacterial paper diaper and use method | |
| CN105998710A (en) | Traditional Chinese medicine composition for treating infantile hemangioma and preparation methods | |
| CN106176398B (en) | A kind of women repairs the preparation method of liquid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20221227 |