CN115501374A

CN115501374A - Hydrophilic fiber dressing and preparation method thereof

Info

Publication number: CN115501374A
Application number: CN202211175152.6A
Authority: CN
Inventors: 徐会军
Original assignee: Shandong Wanrong Biotechnology Co ltd
Current assignee: Shandong Wanrong Biotechnology Co ltd
Priority date: 2022-09-26
Filing date: 2022-09-26
Publication date: 2022-12-23

Abstract

The invention provides a hydrophilic fiber dressing and a preparation method thereof, and relates to the technical field of medical materials. A hydrophilic fiber dressing comprises a wound contact layer, a dressing layer and a carrier layer from inside to outside in sequence; wherein the wound contact layer is made of non-woven fabric soaked with Chinese medicinal extractive solution; the coating layer comprises the following raw materials in parts by weight: 20 to 30 portions of sodium acrylate, 20 to 50 portions of sodium carboxymethylcellulose, 10 to 25 portions of calcined kaolin, 3 to 8 portions of acrylamide, 3 to 5 portions of potassium persulfate, 1 to 3 portions of antibiotic, 3 to 6 portions of honey, 8 to 12 portions of plant polysaccharide and 0.05 to 0.1 portion of vitamin C. The hydrophilic fiber dressing prepared by the invention has excellent bacteriostatic rate, water absorbability and water retentivity, and can be widely applied to wound repair medicines or materials for moderate or severe wounds and hypertonic wounds.

Description

Hydrophilic fiber dressing and preparation method thereof

Technical Field

The invention relates to the technical field of medical materials, in particular to a hydrophilic fiber dressing and a preparation method thereof.

Background

Dressings are indispensable articles in medical treatment, and are generally used for dressing wounds of patients when the wounds of the patients are treated.

The traditional dressing such as various gauzes and cotton pads has the advantages of low cost, wide raw material sources, soft texture, stronger absorption capacity, capability of preventing the seepage accumulation of the wound surface and certain protection effect on the wound surface. However, the traditional dressing can not maintain the moist environment required by wound healing, is easy to adhere to wound tissues, and causes secondary mechanical injury during dressing change. In addition, the traditional dressing has no antibacterial property, and the wound surface is easily infected by bacteria to generate unpleasant smell. In 1962, went doct university in london demonstrated that wounds using moist dressings heal more nearly spontaneously than when exposed to air, with the rate of wound healing being significantly faster, and this was supported by a number of basic and clinical studies. Since a wound generally has a large amount of exudate during the healing process, a high hygroscopic sol fiber wound dressing is clinically required to absorb the exudate to prevent bacterial growth and infection.

Most of the dressings clinically applied at present have poor hygroscopicity, cannot completely absorb exudate at an affected part, even some dressings absorb more liquid and are slightly extruded, the liquid in the dressings can flow out, secondary pollution is caused to wounds, and serious consequences are caused.

Disclosure of Invention

The invention aims to provide a hydrophilic fiber dressing which has the advantages of good antibacterial effect, high water absorption and high water retention rate.

The invention also aims to provide a preparation method of the hydrophilic fiber dressing, which is convenient and simple.

The invention further aims to provide application of the hydrophilic fiber dressing in preparation of wound repair medicines or materials.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

In one aspect, embodiments of the present application provide a hydrophilic fibrous dressing comprising, in order from the inside to the outside, a wound contact layer, a dressing layer, and a carrier layer;

wherein the wound contact layer is made of non-woven fabric soaked with Chinese medicinal extractive solution;

the coating layer comprises the following raw materials in parts by weight: 20 to 30 parts of sodium acrylate, 20 to 50 parts of sodium carboxymethylcellulose, 10 to 25 parts of calcined kaolin, 3 to 8 parts of acrylamide, 3 to 5 parts of potassium persulfate, 1 to 3 parts of antibiotics, 3 to 6 parts of honey, 8 to 12 parts of plant polysaccharide and 0.05 to 0.1 part of vitamin C.

In another aspect, the present application provides a method for preparing a hydrophilic fiber dressing, including the following steps:

uniformly mixing sodium acrylate, sodium carboxymethylcellulose and calcined kaolin, adding acrylamide and potassium persulfate, uniformly stirring, and reacting to obtain gel;

adding antibiotics, honey, plant polysaccharide and vitamin C into the gel, uniformly mixing, and paving on a carrier layer to form a sandwich layer;

soaking the non-woven fabric in the Chinese medicinal extractive solution, and spreading on the dressing layer to form wound contact layer.

In another aspect, the embodiment of the present invention provides an application of the hydrophilic fiber dressing prepared as described above in preparation of a wound repair drug or material.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the wound contact layer is made of non-woven fabrics soaked with traditional Chinese medicine extracting solution, and on the basis of comfort and softness, the traditional Chinese medicine extracting solution can relieve pain, inhibit bacteria and diminish inflammation of a wound and promote the healing of the wound; the dressing layer adopts acrylic acid water-absorbing polymer, sodium carboxymethylcellulose is matched with antibiotics, plant polysaccharide and vitamins, the acrylic acid water-absorbing polymer contains a large amount of carboxyl, the acrylic acid water-absorbing polymer has hydrophilicity and water insolubility, so the high water absorption and expansion degree can be achieved, the sodium carboxymethylcellulose has better water retention performance, the plant polysaccharide can cooperate with the acrylic acid water-absorbing polymer and the sodium carboxymethylcellulose to play a water absorption and water retention effect on the one hand, on the other hand, the plant polysaccharide can influence an endogenous blood coagulation system, platelet aggregation is promoted, thereby achieving a hemostatic effect and being beneficial to wound recovery. The hydrophilic fiber dressing prepared by the invention has excellent antibacterial rate, water absorption and water retention, and can be widely applied to wound repair medicines or materials of moderate or severe wounds and hypertonic wounds.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

Fig. 1 is a cross-sectional view of a hydrophilic fiber dressing according to an embodiment of the present invention.

Icon: 1-a wound contact layer; 2-coating a core layer; 3-a carrier layer.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are not indicated by manufacturers and are commercially available.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

A hydrophilic fiber dressing comprises a wound contact layer, a dressing layer and a carrier layer from inside to outside in sequence;

the core applying layer comprises the following raw materials in parts by weight: 20 to 30 portions of sodium acrylate, 20 to 50 portions of sodium carboxymethylcellulose, 10 to 25 portions of calcined kaolin, 3 to 8 portions of acrylamide, 3 to 5 portions of potassium persulfate, 1 to 3 portions of antibiotic, 3 to 6 portions of honey, 8 to 12 portions of plant polysaccharide and 0.05 to 0.1 portion of vitamin C.

The wound contact layer is made of non-woven fabrics soaked with traditional Chinese medicine extracting solution, and on the basis of comfort and softness, the traditional Chinese medicine extracting solution can relieve pain, inhibit bacteria and diminish inflammation of a wound and promote the healing of the wound; the dressing layer adopts acrylic acid water-absorbing polymer, sodium carboxymethylcellulose is matched with antibiotics, plant polysaccharide and vitamins, the acrylic acid water-absorbing polymer contains a large amount of carboxyl, the acrylic acid water-absorbing polymer has hydrophilicity and water insolubility, so the high water absorption and expansion degree can be achieved, the sodium carboxymethylcellulose has better water retention performance, the plant polysaccharide can cooperate with the acrylic acid water-absorbing polymer and the sodium carboxymethylcellulose to play a water absorption and water retention effect on the one hand, on the other hand, the plant polysaccharide can influence an endogenous blood coagulation system, platelet aggregation is promoted, thereby achieving a hemostatic effect and being beneficial to wound recovery.

In some embodiments of the present invention, the Chinese herbs in the Chinese herb extract comprise frankincense, notoginseng, green tea and seabuckthorn; the weight ratio of the frankincense, the pseudo-ginseng, the green tea and the sea buckthorn is 10: (3-5): (5-8): (3-5).

In some embodiments of the present invention, the plant polysaccharide comprises one or more of bletilla striata polysaccharide, aloe polysaccharide, angelica polysaccharide and astragalus polysaccharide.

The pseudo-ginseng and sea backthern of the invention activate blood and relieve pain, the green tea is anti-inflammatory and antibacterial, the frankincense extract can promote the increase of multinuclear white blood cells, phagocytose dead blood cells and cells, improve metabolism, and enhance the anti-inflammatory effect by matching with polysaccharide, and the substance can play a role in relieving pain because the frankincense extract contains n-octyl acetate, and the non-woven fabric is soaked by adopting the traditional Chinese medicine extracting solution, so that the softness and skin friendliness of the non-woven fabric can be ensured, the traditional Chinese medicine extracting solution can be rapidly contacted with wounds, and the effects of relieving pain and diminishing inflammation can be achieved.

In some embodiments of the present invention, the nonwoven fabric is prepared from a mixture of 1: (0.5-1) the carrier layer is a PU film.

In some embodiments of the present invention, the neutralization degree of the sodium acrylate is 58 to 62%, and the antibiotic is one or more of aspirin, gentamicin, and erythromycin hydrochloride.

A preparation method of a hydrophilic fiber dressing comprises the following steps:

In some embodiments of the present invention, the reaction time in the step of forming the gel is 4 to 6 hours, and the reaction temperature is 50 to 60 ℃.

In some embodiments of the invention, the ratio of the thicknesses of the wound contact layer, the dressing layer and the carrier layer is (3-5): (6-12): 1. the thickness of the wound contact layer is 1/4-2/3 of that of the dressing layer, and the dressing layer can be used for different types and different degrees of wound types.

In some embodiments of the present invention, the preparation process of the wound contact layer is specifically as follows: cutting the alginate fibers and the bamboo fibers into short fibers with the length of 20-30 mm, mixing, carding, cross lapping, needle punching forming, baking in an oven and calendaring forming to prepare non-woven fabrics, soaking the non-woven fabrics in the traditional Chinese medicine extracting solution for 2-4 h, taking out and drying in the air. The bamboo fiber has air permeability and certain strength, and the alginate fiber has negative ions, and can promote metabolism and promote wound healing.

In some embodiments of the present invention, the preparation method of the traditional Chinese medicine extract comprises: washing the traditional Chinese medicinal materials with water, cutting into sections, adding 10-15 times of clear water by weight, boiling with strong fire, then boiling with slow fire, filtering out dregs after 2-4 h, and taking the filtrate.

In some embodiments of the present invention, the calcined kaolin is specifically calcined at 400-550 ℃ for 1-2 h. The kaolin is calcined at high temperature, so that the activity of the kaolin can be improved, and the water absorption and water retention are improved.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

A hydrophilic fibrous dressing comprising, in order from the inside to the outside, a wound contact layer 1, a dressing layer 2 and a carrier layer 3, as shown in figure 1, is prepared by the following process:

cutting PU films with different sizes and shapes as a carrier layer 3;

directly calcining kaolin at 500 ℃ for 1h to obtain calcined kaolin for later use; adding sodium hydroxide into acrylic acid, and adjusting the neutralization degree to 59% to obtain a sodium acrylate solution of the embodiment for later use; pouring 20g of sodium acrylate solution, 50g of sodium carboxymethylcellulose and 20g of calcined kaolin into a 250mL conical flask, uniformly mixing, adding 5g of acrylamide and 4g of potassium persulfate, and continuously stirring for reaction for 5 hours at the water bath temperature of 55 ℃ to obtain a brownish yellow transparent jelly, namely gel; adding 3g of aspirin, 5g of honey, 2g of bletilla striata polysaccharide, 5g of aloe polysaccharide, 3g of astragalus polysaccharide and 0.1g of vitamin C powder into the gel, uniformly mixing, pouring the mixture on a carrier layer 3, and uniformly paving to obtain a coating layer 2, wherein the area of the coating layer 2 is slightly smaller than that of the carrier layer 3;

taking the weight ratio of 1:1, cutting the seaweed fiber and the bamboo fiber into short fibers with the length of 25-30 mm, and preparing the short fibers into non-woven fabric through mixing, carding, cross lapping, needle punching forming, baking in an oven and calendaring forming; taking 10g of frankincense, 5g of pseudo-ginseng, 6g of green tea and 4g of sea buckthorn, washing with clear water to remove impurities, cutting into small segments with the length of 0.5-1 cm, putting the small segments into a boiling tank, adding 15 times of water by weight, boiling with big fire, then boiling with small fire, turning off the fire after 2 hours, filtering with a filter screen for 3 times after the liquid medicine is cooled, and removing the traditional Chinese medicinal materials and dregs to obtain a traditional Chinese medicine extracting solution; soaking the non-woven fabric in the traditional Chinese medicine extracting solution for 3h, taking out the non-woven fabric, naturally drying, laying the non-woven fabric at the upper end of the dressing layer 2, directly connecting the side edge of the non-woven fabric with the carrier layer 3, and completely covering the dressing layer 2 inside to form a wound contact layer 1;

the thickness ratio of wound contact layer 1, wicking layer 2 and carrier layer 3 in this example was 3:10:1, finally preparing the hydrophilic fiber dressing of the embodiment.

Example 2

A hydrophilic fiber dressing comprising, inside and outside, in sequence, a wound contact layer 1, a dressing layer 2 and a carrier layer 3, is prepared by the following process:

cutting PU films of different sizes and shapes as a carrier layer 3;

directly calcining kaolin for 1.5h at 550 ℃ to obtain calcined kaolin for later use; adding sodium hydroxide into acrylic acid, and adjusting the neutralization degree to 62% to obtain a sodium acrylate solution of the embodiment for later use; pouring 30g of sodium acrylate solution, 30g of sodium carboxymethylcellulose and 15g of calcined kaolin into a 250mL conical flask, uniformly mixing, adding 8g of acrylamide and 3g of potassium persulfate, and continuously stirring for reacting for 5.5 hours at the water bath temperature of 50 ℃ to obtain a brownish transparent jelly, namely gel; adding 2g of gentamicin, 6g of honey, 5g of bletilla striata polysaccharide, 4g of angelica polysaccharide and 0.05g of vitamin C powder into the gel, uniformly mixing, pouring the mixture on a carrier layer 3, and paving the mixture evenly to obtain a coating layer 2, wherein the area of the coating layer 2 is slightly smaller than that of the carrier layer 3;

taking the components in a weight ratio of 1:0.7 of seaweed fiber and bamboo fiber are cut into short fiber with the length of 20-30 mm, and the short fiber are mixed, carded, crossed and lapped, formed by needling, baked in an oven and formed by calendaring to prepare non-woven fabric; taking 10g of frankincense, 4g of pseudo-ginseng, 8g of green tea and 3g of sea buckthorn, washing with clear water to remove impurities, cutting into small segments with the length of 0.5-1 cm, putting the small segments into a boiling tank, adding 10 times of water by weight, boiling with big fire, then boiling with small fire, turning off the fire after 4 hours, filtering with a filter screen for 2 times after the liquid medicine is cooled, and removing the traditional Chinese medicinal materials and dregs to obtain a traditional Chinese medicine extracting solution; soaking the non-woven fabric in the traditional Chinese medicine extracting solution for 3h, taking out the non-woven fabric, naturally drying, laying the non-woven fabric at the upper end of the dressing layer 2, directly connecting the side edge of the non-woven fabric with the carrier layer 3, and completely covering the dressing layer 2 inside to form a wound contact layer 1;

the thickness ratio of wound contact layer 1, wicking layer 2 and carrier layer 3 in this example was 5:12:1, finally preparing the hydrophilic fiber dressing of the embodiment.

Example 3

A hydrophilic fiber dressing comprises a wound contact layer 1, a dressing layer 2 and a carrier layer 3 in turn from inside to outside, and is prepared by the following method:

cutting PU films of different sizes and shapes as a carrier layer 3;

directly calcining kaolin at 400 ℃ for 2h to obtain calcined kaolin for later use; adding sodium hydroxide into acrylic acid, and adjusting the neutralization degree to 58% to obtain a sodium acrylate solution of the embodiment for later use; pouring 25g of sodium acrylate solution, 35g of sodium carboxymethylcellulose and 25g of calcined kaolin into a 250mL conical flask, uniformly mixing, adding 3g of acrylamide and 5g of potassium persulfate, and continuously stirring for reacting for 4 hours at the water bath temperature of 60 ℃ to obtain a brownish yellow transparent jelly, namely gel; adding 2g of gentamicin, 1g of erythromycin hydrochloride, 4g of honey, 8g of angelica polysaccharide and 0.08g of vitamin C powder into the gel, uniformly mixing, pouring the mixture on a carrier layer 3, and paving the mixture evenly to obtain a core applying layer 2, wherein the area of the core applying layer 2 is slightly smaller than that of the carrier layer 3;

taking the components in a weight ratio of 1:0.5 of seaweed fiber and bamboo fiber are cut into short fiber with the length of 20-30 mm, and the short fiber are mixed, carded, crossed and lapped, formed by needling, baked in an oven and formed by calendaring to prepare non-woven fabric; washing 10g of frankincense, 3g of pseudo-ginseng, 5g of green tea and 5g of sea buckthorn with clear water to remove impurities, cutting into small segments with the length of 0.5-1 cm, putting the small segments into a boiling pot, adding 12 times of water by weight, boiling with big fire, turning to small fire for boiling, turning off the fire after 3 hours, filtering with a filter screen for 2 times after the liquid medicine is cooled, and removing traditional Chinese medicinal materials and dregs to obtain a traditional Chinese medicine extracting solution; the non-woven fabric is comprehensively soaked in the traditional Chinese medicine extracting solution for 4 hours, then is taken out to be naturally dried, is laid at the upper end of the compress layer 2, the side edge of the non-woven fabric is directly connected with the carrier layer 3, and the compress layer 2 is completely covered inside to form a wound contact layer 1;

the thickness ratio of wound contact layer 1, wicking layer 2 and carrier layer 3 in this example was 3:9:1, finally preparing the hydrophilic fiber dressing of the embodiment.

Example 4

cutting PU films of different sizes and shapes as a carrier layer 3;

directly calcining kaolin for 1h at 450 ℃ to obtain calcined kaolin for later use; adding sodium hydroxide into acrylic acid, and adjusting the neutralization degree to 60% to obtain a sodium acrylate solution of the embodiment for later use; pouring 30g of sodium acrylate solution, 20g of sodium carboxymethylcellulose and 25g of calcined kaolin into a 250mL conical flask, uniformly mixing, adding 3g of acrylamide and 5g of potassium persulfate, and continuously stirring for reacting for 4 hours at the water bath temperature of 60 ℃ to obtain a brownish yellow transparent jelly, namely gel; adding 2g of gentamicin, 1g of erythromycin hydrochloride, 4g of honey, 8g of angelica polysaccharide, 2g of astragalus polysaccharide and 0.1g of vitamin C powder into the gel, uniformly mixing, pouring the mixture on a carrier layer 3, and paving the mixture evenly to obtain a coating core layer 2, wherein the area of the coating core layer 2 is slightly smaller than that of the carrier layer 3;

taking the components in a weight ratio of 1:1, cutting the seaweed fiber and the bamboo fiber into short fibers with the length of 20-30 mm, and preparing the short fibers into non-woven fabric through mixing, carding, cross lapping, needle punching forming, baking in an oven and calendaring forming; taking 10g of frankincense, 3g of pseudo-ginseng, 5g of green tea and 4g of sea buckthorn, washing with clear water to remove impurities, cutting into small segments with the length of 0.5-1 cm, putting the small segments into a boiling tank, adding 12 times of water by weight, boiling with big fire, then boiling with small fire, turning off the fire after 2 hours, filtering with a filter screen for 2 times after the liquid medicine is cooled, and removing the traditional Chinese medicinal materials and dregs to obtain a traditional Chinese medicine extracting solution; the non-woven fabric is comprehensively soaked in the traditional Chinese medicine extracting solution for 2 hours, then is taken out to be naturally dried, is laid at the upper end of the compress layer 2, the side edge of the non-woven fabric is directly connected with the carrier layer 3, and the compress layer 2 is completely covered inside to form a wound contact layer 1;

the thickness ratio of wound contact layer 1, wicking layer 2 and carrier layer 3 in this example was 4:6:1, finally preparing the hydrophilic fiber dressing of the embodiment.

Example 5

cutting PU films of different sizes and shapes as a carrier layer 3;

directly calcining kaolin at 550 ℃ for 2 hours to obtain calcined kaolin for later use; adding sodium hydroxide into acrylic acid, and adjusting the neutralization degree to 61% to obtain a sodium acrylate solution of the embodiment for later use; pouring 20g of sodium acrylate solution, 30g of sodium carboxymethylcellulose and 25g of calcined kaolin into a 250mL conical flask, uniformly mixing, adding 3g of acrylamide and 5g of potassium persulfate, and continuously stirring for reacting for 4 hours at the water bath temperature of 60 ℃ to obtain a brownish yellow transparent jelly, namely gel; adding 2g of gentamicin, 1g of erythromycin hydrochloride, 5g of honey, 8g of aloe polysaccharide, 1g of astragalus polysaccharide and 0.1g of vitamin C powder into the gel, uniformly mixing, pouring the mixture on a carrier layer 3, and paving the mixture evenly to obtain a coating layer 2, wherein the area of the coating layer 2 is slightly smaller than that of the carrier layer 3;

taking the components in a weight ratio of 1:1, cutting the seaweed fiber and the bamboo fiber into short fibers with the length of 20-25 mm, and preparing the short fibers into non-woven fabric through mixing, carding, cross lapping, needle punching forming, baking in an oven and calendaring forming; washing 10g of frankincense, 5g of pseudo-ginseng, 5g of green tea and 4g of sea buckthorn with clear water to remove impurities, cutting into small segments with the length of 0.5-1 cm, putting the small segments into a boiling pot, adding 12 times of water by weight, boiling with big fire, turning to small fire for boiling, turning off the fire after 2 hours, filtering with a filter screen for 2 times after the liquid medicine is cooled, and removing traditional Chinese medicinal materials and dregs to obtain a traditional Chinese medicine extracting solution; soaking the non-woven fabric in the traditional Chinese medicine extracting solution for 2h, taking out the non-woven fabric, naturally drying, laying the non-woven fabric at the upper end of the dressing layer 2, directly connecting the side edge of the non-woven fabric with the carrier layer 3, and completely covering the dressing layer 2 inside to form a wound contact layer 1;

the thickness ratio of wound contact layer 1, wicking layer 2 and carrier layer 3 in this example was 3:8:1, finally preparing the hydrophilic fiber dressing of the embodiment.

Comparative example 1

The comparative example is different from example 1 in that there is no herb extract in the comparative example, i.e., the step of soaking the non-woven fabric in the herb extract is eliminated.

Comparative example 2

The comparative example differs from example 1 in that no plant polysaccharide is added to the wicking layer 2 in the comparative example.

Comparative example 3

The difference between this comparative example and example 1 is that there is no wound contact layer 1 in this comparative example, and the Chinese medicinal extract was concentrated into a paste and added to the gel.

Comparative example 4

This comparative example differs from example 1 in that there is no cladding layer 2.

Experimental example 1

This example 1 demonstrates the bacteriostatic effect of the hydrophilic fiber dressing of the present invention.

The hydrophilic fiber dressings prepared in examples 1 to 5 and comparative examples 1 to 4 were cut into a circular shape having a size of 10 mm. The determination was carried out according to the sterilization procedure of part 5 of the YY/T0471.5 contact wound dressing test method, under moist conditions, in order to evaluate the ability of wound alginate dressings to prevent the passage of bacteria under moist conditions. The results of the experiment are shown in table 1.

TABLE 1

As can be seen from Table 1, examples 1-5, comparative example 2 and comparative example 3 all have better antibacterial rate, and the antibacterial rate of comparative example 1 and comparative example 4 is obviously reduced, which indicates that the dressing can be assisted by the dressing layer 2 and the traditional Chinese medicine extract to have better antibacterial effect.

Experimental example 2

This experimental example investigated the moisture absorption and retention effects of the hydrophilic fiber dressing of the present invention.

Preparing 9 beakers, respectively filling 500mL of NaCl solution with the percentage content of 0.9%, respectively taking 0.5g (W1) of the hydrophilic fiber dressings prepared in the examples 1-5 and the comparative examples 1-4, putting the hydrophilic fiber dressings into saline water to fully absorb water, fishing out after 30min, sequentially weighing the hydrophilic fiber dressings (W2), and calculating the saline water absorption multiplying power Q1, wherein the calculation formula is Q1= (W2-W1)/W1.

The dressings absorbed with water in each experimental group were dried at 60 ℃ for 20min, and the mass (W3) thereof was further weighed, and the water retention rate Q2 was calculated, Q2= W3/W2, and the results of Q1 and Q2 are shown in table 2.

TABLE 2

Grouping	Water absorption multiplying power Q1	Water retention Rate Q2
			Example 1	23.17	0.912
Example 2	21.59	0.883
			Example 3	24.84	0.878
Example 4	21.68	0.892
			Example 5	19.88	0.906
Comparative example 1	20.57	0.895
			Comparative example 2	18.95	0.822
Comparative example 3	15.52	0.905
			Comparative example 4	7.21	0.361

As can be seen from Table 2, the hydrophilic fiber dressings prepared in examples 1 to 5 all had excellent water absorbability and water retentivity; the comparative example 1 lacks traditional Chinese medicine extract, and basically has no influence on water retention and moisture retention; the plant polysaccharide is absent in the comparative example 2, the water absorption rate and the water retention rate of the plant polysaccharide are slightly reduced, and the plant polysaccharide and the acrylic acid polymer in the applied core layer 2 have a synergistic effect on water absorption; comparative example 3, which lacks a nonwoven fabric, has slightly decreased water absorption but better water retention, shows that the nonwoven fabric as the wound contact layer 1 can enhance the effect of absorbing exudate; comparative example 4, which has no core layer, has a significantly reduced water absorption capacity and a poor water retention rate, shows that the water absorption is poor and the re-penetration is easy to cause secondary infection only by the nonwoven fabric.

In summary, the hydrophilic fiber dressing and the preparation method thereof provided by the embodiment of the invention are provided with the wound contact layer, the dressing layer and the carrier layer, wherein the wound contact layer is made of non-woven fabrics soaked with the traditional Chinese medicine extracting solution, and on the basis of comfort and softness, the traditional Chinese medicine extracting solution can relieve pain, inhibit bacteria and diminish inflammation of the wound and promote the healing of the wound; the dressing layer is made of acrylic acid water-absorbing polymer, sodium carboxymethylcellulose is matched with antibiotics, plant polysaccharide and vitamins, the acrylic acid water-absorbing polymer contains a large amount of carboxyl, the acrylic acid water-absorbing polymer has hydrophilicity and is non-water-soluble, so that high water absorption and expansion degrees can be achieved, the sodium carboxymethylcellulose has good water retention performance, the plant polysaccharide can cooperate with the acrylic acid water-absorbing polymer and the sodium carboxymethylcellulose to achieve the effects of water absorption and water retention, and on the other hand, the plant polysaccharide can influence an endogenous blood coagulation system and promote platelet aggregation, so that a hemostatic effect is achieved, and the wound recovery is facilitated. The hydrophilic fiber dressing prepared by the invention has excellent antibacterial rate, water absorption and water retention, and can be widely applied to wound repair medicines or materials of moderate or severe wounds and hypertonic wounds.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.

Claims

1. A hydrophilic fiber dressing is characterized by comprising a wound contact layer, a dressing layer and a carrier layer in sequence from inside to outside;

the core applying layer comprises the following raw materials in parts by weight: 20 to 30 parts of sodium acrylate, 20 to 50 parts of sodium carboxymethylcellulose, 10 to 25 parts of calcined kaolin, 3 to 8 parts of acrylamide, 3 to 5 parts of potassium persulfate, 1 to 3 parts of antibiotics, 3 to 6 parts of honey, 8 to 12 parts of plant polysaccharide and 0.05 to 0.1 part of vitamin C.

2. The hydrophilic fiber dressing of claim 1, wherein the Chinese herbs in the Chinese herb extract comprise frankincense, pseudo-ginseng, green tea and sea buckthorn; the weight ratio of the frankincense, the pseudo-ginseng, the green tea and the sea buckthorn is 10: (3-5): (5-8): (3-5).

3. The hydrophilic fibrous dressing of claim 2, wherein the plant polysaccharide comprises one or more of bletilla striata polysaccharide, aloe polysaccharide, angelica polysaccharide and astragalus polysaccharide.

4. The hydrophilic fiber dressing according to claim 1, wherein the non-woven fabric is prepared from the following raw materials in a weight ratio of 1: (0.5-1) and bamboo fiber, and the carrier layer is a PU film.

5. The hydrophilic fiber dressing according to claim 1, wherein the neutralization degree of the sodium acrylate is 58-62%, and the antibiotic is one or more of aspirin, gentamicin and erythromycin hydrochloride.

6. A method for preparing the hydrophilic fiber dressing according to claims 1-5, comprising the steps of:

7. The method for preparing the hydrophilic fiber dressing according to claim 6, wherein the reaction time in the step of generating the gel is 4-6 h, and the reaction temperature is 50-60 ℃.

8. The method for preparing the hydrophilic fiber dressing according to claim 6, wherein the thickness ratio of the wound contact layer to the dressing layer to the carrier layer is (3-5): (6-12): 1.

9. the method for preparing the hydrophilic fiber dressing according to claim 6, wherein the wound contact layer is prepared by the following specific steps: cutting the alginate fibers and the bamboo fibers into short fibers with the length of 20-30 mm, mixing, carding, cross lapping, needle punching forming, baking in an oven and calendaring forming to prepare non-woven fabrics, soaking the non-woven fabrics in the traditional Chinese medicine extracting solution for 2-4 h, taking out and drying in the air.

10. The method for preparing the hydrophilic fiber dressing according to claim 9, wherein the method for preparing the traditional Chinese medicine extracting solution comprises the following steps: washing the traditional Chinese medicinal materials with water, cutting into sections, adding 10-15 times of clear water by weight, boiling with strong fire, then boiling with slow fire, filtering out dregs after 2-4 h, and taking the filtrate.