CN115486446A - Efficient cyhalothrin and preparation method thereof - Google Patents
Efficient cyhalothrin and preparation method thereof Download PDFInfo
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- CN115486446A CN115486446A CN202211196107.9A CN202211196107A CN115486446A CN 115486446 A CN115486446 A CN 115486446A CN 202211196107 A CN202211196107 A CN 202211196107A CN 115486446 A CN115486446 A CN 115486446A
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- percent
- parts
- polyoxyethylene ether
- cyhalothrin
- drug
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- ZXQYGBMAQZUVMI-UNOMPAQXSA-N cyhalothrin Chemical compound CC1(C)C(\C=C(/Cl)C(F)(F)F)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-UNOMPAQXSA-N 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 65
- 229940079593 drug Drugs 0.000 claims abstract description 25
- ZFRKQXVRDFCRJG-UHFFFAOYSA-N skatole Chemical compound C1=CC=C2C(C)=CNC2=C1 ZFRKQXVRDFCRJG-UHFFFAOYSA-N 0.000 claims abstract description 20
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000006229 carbon black Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000002906 tartaric acid Nutrition 0.000 claims abstract description 12
- 239000011975 tartaric acid Substances 0.000 claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 11
- 229940074386 skatole Drugs 0.000 claims abstract description 10
- 108010010803 Gelatin Proteins 0.000 claims abstract description 9
- 239000002270 dispersing agent Substances 0.000 claims abstract description 9
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 9
- 239000000945 filler Substances 0.000 claims abstract description 9
- 239000008273 gelatin Substances 0.000 claims abstract description 9
- 229920000159 gelatin Polymers 0.000 claims abstract description 9
- 235000019322 gelatine Nutrition 0.000 claims abstract description 9
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000004014 plasticizer Substances 0.000 claims abstract description 9
- 239000003755 preservative agent Substances 0.000 claims abstract description 9
- 230000002335 preservative effect Effects 0.000 claims abstract description 9
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 9
- 239000011230 binding agent Substances 0.000 claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 6
- 239000007884 disintegrant Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000000575 pesticide Substances 0.000 claims abstract description 5
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 28
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 28
- 239000002775 capsule Substances 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 239000003292 glue Substances 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 239000011265 semifinished product Substances 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- TVFWYUWNQVRQRG-UHFFFAOYSA-N 2,3,4-tris(2-phenylethenyl)phenol Chemical compound C=1C=CC=CC=1C=CC1=C(C=CC=2C=CC=CC=2)C(O)=CC=C1C=CC1=CC=CC=C1 TVFWYUWNQVRQRG-UHFFFAOYSA-N 0.000 claims description 6
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 6
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- -1 polyoxypropylene Polymers 0.000 claims description 6
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 6
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 239000000428 dust Substances 0.000 claims description 5
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 claims description 3
- 229920002261 Corn starch Polymers 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 3
- ZRIUUUJAJJNDSS-UHFFFAOYSA-N ammonium phosphates Chemical compound [NH4+].[NH4+].[NH4+].[O-]P([O-])([O-])=O ZRIUUUJAJJNDSS-UHFFFAOYSA-N 0.000 claims description 3
- 229920005551 calcium lignosulfonate Polymers 0.000 claims description 3
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 claims description 3
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 claims description 3
- ZWRCDCXUOBLXKM-UHFFFAOYSA-N carbonic acid;morpholine Chemical compound OC([O-])=O.C1COCC[NH2+]1 ZWRCDCXUOBLXKM-UHFFFAOYSA-N 0.000 claims description 3
- 239000004359 castor oil Substances 0.000 claims description 3
- 235000019438 castor oil Nutrition 0.000 claims description 3
- 239000008120 corn starch Substances 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 3
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 claims description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
- 229920001451 polypropylene glycol Polymers 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000007493 shaping process Methods 0.000 claims description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 3
- 229920005552 sodium lignosulfonate Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000001384 succinic acid Substances 0.000 claims description 3
- 229920000142 Sodium polycarboxylate Polymers 0.000 claims description 2
- ZXQYGBMAQZUVMI-RDDWSQKMSA-N (1S)-cis-(alphaR)-cyhalothrin Chemical compound CC1(C)[C@H](\C=C(/Cl)C(F)(F)F)[C@@H]1C(=O)O[C@@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-RDDWSQKMSA-N 0.000 claims 1
- 239000005910 lambda-Cyhalothrin Substances 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 4
- 239000001569 carbon dioxide Substances 0.000 abstract description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 2
- 239000003094 microcapsule Substances 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 4
- 239000004530 micro-emulsion Substances 0.000 description 4
- 241000238631 Hexapoda Species 0.000 description 3
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000004562 water dispersible granule Substances 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of pesticide preparation processing, in particular to efficient cyhalothrin and a preparation method thereof, wherein a drug core is hermetically stored through a drug coat, so that the drug is conveniently stored, the drug caking is reduced, the drug coat is slowly softened by putting the drug into water when in use, simultaneously sodium carbonate reacts with tartaric acid to generate a large amount of carbon dioxide, and the drug coat is rapidly disintegrated by the action of a disintegrant, so that the drug core is dissolved into water, the contact between a user and the drug core is reduced, and the practicability of the efficient cyhalothrin is improved; the method comprises the following raw materials: the medicine core: 0.1-10 parts of efficient cyhalothrin, 1-10 parts of solvent, 1-20 parts of white carbon black, 1-10 parts of emulsifier, 1-10 parts of dispersant, 100 parts of inert filler and 1-5 parts of binder: 10 to 15 percent of gelatin, 1 to 15 percent of plasticizer, 5 to 15 percent of disintegrating agent, 3 to 10 percent of water, 5 to 15 percent of skatole, 0.1 to 0.3 percent of preservative, 15 to 20 percent of powdery sodium carbonate and 20 to 25 percent of powdery tartaric acid.
Description
Technical Field
The invention relates to the technical field of pesticide preparation processing, in particular to efficient cyhalothrin and a preparation method thereof.
Background
Cyhalothrin has the effects of avoiding insects, knocking down insects and killing insects, and is widely applied to grassland, grassland and upland crops for controlling meadow borers and the like, the existing efficient cyhalothrin has more dosage forms, such as missible oil, aqueous emulsion, microemulsion, wettable powder, water dispersible granules, microcapsules and the like, for example, the efficient cyhalothrin microcapsule suspending agent and the preparation method thereof provided in the granted patent with the application number of CN202110086801.4, the efficient cyhalothrin microcapsule suspending agent has the average microcapsule particle size of 3-5 mu m \8230, \8230, and the weight of white carbon black is more than or equal to half of the total weight of the efficient cyhalothrin and the solvent. The existing cyhalothrin aqueous emulsion and microemulsion contain part of high-efficiency cyhalothrin which is easy to volatilize in traditional solvents, so that the skin of a human body is easy to be allergic, and red, swollen and itching occur, compared with other microcapsules, the microcapsule has higher cost, powder is easy to be damped and deblocked, and the existing cyhalothrin aqueous emulsion and microemulsion need to be improved due to the fact that the existing cyhalothrin aqueous emulsion and microemulsion are poor in practicability because the powder is large in dust and inconvenient to control the dosage during use.
Disclosure of Invention
In order to solve the technical problems, the invention provides the efficient cyhalothrin and the preparation method thereof, wherein the medicine core is hermetically stored through the medicine coat, the medicine is conveniently stored, the medicine caking is reduced, the medicine is put into water when the efficient cyhalothrin is used, the medicine coat is slowly softened, simultaneously, sodium carbonate reacts with tartaric acid to generate a large amount of carbon dioxide, and the medicine coat is rapidly disintegrated through the action of a disintegrating agent, so that the medicine core is dissolved into the water, the contact between a user and the medicine core is reduced, and the practicability of the efficient cyhalothrin is improved.
The invention relates to efficient cyhalothrin, which comprises the following raw materials:
the medicine core: 0.1-10 parts of efficient cyhalothrin, 1-10 parts of solvent, 1-20 parts of white carbon black, 1-10 parts of emulsifier, 1-10 parts of dispersant, 100 parts of inert filler and 1-5 parts of binder
Coating with a medicine: 10 to 15 percent of gelatin, 1 to 15 percent of plasticizer, 5 to 15 percent of disintegrant, 3 to 10 percent of water, 5 to 15 percent of skatole, 0.1 to 0.3 percent of preservative, 15 to 20 percent of powdery sodium carbonate and 20 to 25 percent of powdery tartaric acid.
Preferably, the emulsifier is one or more of alkylphenol ethoxylates, benzyl phenol polyoxyethylene ether, phenethylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, phenethylphenol polyoxyethylene ether polyoxypropylene ether, fatty amine polyoxyethylene ether, fatty acid and ethylene oxide adduct, castor oil and ethylene oxide adduct and derivatives thereof, sodium dodecylbenzene sulfonate, calcium dodecylbenzene sulfonate, anionic aryl polyoxyalkyl sulfate, alkyl polyoxyethylene ether and anionic alkyl sulfonate.
Preferably, the dispersant is selected from one or more of tristyrylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether phosphate, tristyrylphenol polyoxyethylene ether phosphate ammonium salt, naphthalenesulfonate formaldehyde condensate sulfonate, succinic acid sulfonate, sodium lignosulfonate, calcium lignosulfonate, and polycarboxylic acid sodium salt.
Preferably, the inert material is corn starch.
The invention relates to a preparation method of efficient cyhalothrin, which comprises the following steps:
mixing efficient cyhalothrin, a solvent and an emulsifying machine to form a mixture, pouring white carbon black into the mixture to enable the white carbon black to adsorb the mixture, pouring inert filler into the mixture to uniformly mix to form a semi-finished product, drying the semi-finished product, crushing and grinding the semi-finished product to prepare particles to form a medicine core;
step two, mixing and stirring gelatin, plasticizer and water to prepare capsule material glue solution, then pouring skatole and preservative into the capsule material glue solution for fully mixing, then pouring disintegrating agent, powdery carbonic acid morpholine and powdery tartaric acid into the capsule material glue solution for fully mixing, and then shaping the capsule material glue solution to form a capsule coat;
step three, pouring the drug core into the capsule outer coat, and closing the upper capsule outer coat and the lower capsule outer coat to form the drug;
step four, pouring the medicine into the pesticide bottle in a fixed amount, and sealing.
Preferably, the medicines in each bottle are divided into three medicines with different masses, namely small, medium and large medicines, and the surface of the capsule coat is engraved with mass parameters; the user can conveniently select the medicines with different sizes according to the dosage.
Preferably, in the crushing and grinding process, dust removal treatment is carried out; the influence of dust on the surrounding environment and the body of workers is reduced.
Preferably, the core has a ground particle size of less than 4 microns.
Compared with the prior art, the invention has the beneficial effects that:
1. the medicine core is wrapped by the medicine coat, so that the contact between the medicine core and air and moisture is reduced, the volatilization of the medicine is reduced, the contact between a user and the medicine core is reduced, and the convenience of medicine storage is improved;
2. the dosage can be conveniently controlled according to the size of the medicine, and the convenience of the medicine use is improved;
3. through the matching of the disintegrating agent, the powdery sodium carbonate and the powdery tartaric acid, the medicine coat is quickly disintegrated, and the practicability of the medicine is improved.
Detailed Description
The present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Example 1
The method comprises the following raw materials:
the medicine core is as follows: 0.1-5 parts of efficient cyhalothrin, 1-3 parts of solvent, 1-7 parts of white carbon black, 1-3 parts of emulsifier, 1-3 parts of dispersant, 100 parts of inert filler complement and 1 part of binder
Coating with a medicine: 10 to 15 percent of gelatin, 1 to 15 percent of plasticizer, 5 to 15 percent of disintegrant, 3 to 10 percent of water, 5 to 15 percent of skatole, 0.1 to 0.3 percent of preservative, 15 to 20 percent of powdery sodium carbonate and 20 to 25 percent of powdery tartaric acid.
Example 2
The method comprises the following raw materials:
the medicine core: 5-7 parts of efficient cyhalothrin, 5-7 parts of solvent, 7-13 parts of white carbon black, 7-7 parts of emulsifier, 5-7 parts of dispersant, 100 parts of inert filler and 3 parts of binder
Coating with medicine: 10 to 15 percent of gelatin, 1 to 15 percent of plasticizer, 5 to 15 percent of disintegrant, 3 to 10 percent of water, 5 to 15 percent of skatole, 0.1 to 0.3 percent of preservative, 15 to 20 percent of powdery sodium carbonate and 20 to 25 percent of powdery tartaric acid.
Example 3
The method comprises the following raw materials:
the medicine core is as follows: 7-10 parts of efficient cyhalothrin, 7-10 parts of solvent, 13-20 parts of white carbon black, 7-10 parts of emulsifier, 7-10 parts of dispersant, 100 parts of inert filler and 5 parts of binder
Coating with a medicine: 10 to 15 percent of gelatin, 1 to 15 percent of plasticizer, 5 to 15 percent of disintegrant, 3 to 10 percent of water, 5 to 15 percent of skatole, 0.1 to 0.3 percent of preservative, 15 to 20 percent of powdery sodium carbonate and 20 to 25 percent of powdery tartaric acid.
The emulsifier is one or more of alkylphenol polyoxyethylene ether, benzyl phenol polyoxyethylene ether, phenethyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, phenethyl phenol polyoxyethylene ether polyoxypropylene ether, fatty amine polyoxyethylene ether, addition product of fatty acid and ethylene oxide, addition product of castor oil and ethylene oxide and derivatives thereof, sodium dodecyl benzene sulfonate, calcium dodecyl benzene sulfonate, anionic aryl polyoxyalkyl sulfate, alkyl polyoxyethylene ether and anionic alkyl sulfonate;
the dispersing agent is selected from one or more of tristyrylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether phosphate, tristyrylphenol polyoxyethylene ether phosphate ammonium salt, naphthalenesulfonate formaldehyde condensate sulfonate, succinic acid sulfonate, sodium lignosulfonate, calcium lignosulfonate and sodium polycarboxylate;
the inert material is corn starch.
The preparation method comprises the following steps:
step one, mixing efficient cyhalothrin, a solvent and an emulsifying machine to form a mixture, pouring white carbon black into the mixture to enable the white carbon black to adsorb the mixture, pouring inert filler into the mixture to uniformly mix to form a semi-finished product, then drying the semi-finished product, crushing and grinding, enabling the grinding particle size of a medicine core to be smaller than 4 microns, and simultaneously performing dust removal treatment to prepare particles to form the medicine core;
step two, mixing and stirring gelatin, plasticizer and water to prepare capsule material glue solution, then pouring skatole and preservative into the capsule material glue solution for fully mixing, then pouring disintegrating agent, powdery carbonic acid morpholine and powdery tartaric acid into the capsule material glue solution for fully mixing, and then shaping the capsule material glue solution to form a capsule coat;
step three, pouring the drug core into the capsule coat, and closing the upper capsule coat and the lower capsule coat to form the drug;
and step four, pouring the medicines into the pesticide bottles in a quantitative manner, sealing the bottles, wherein the medicines in each bottle are divided into three medicines with different masses, namely small, medium and large, and quality parameters are engraved on the surface of the capsule coat.
The main functions realized by the invention are as follows: the storage is convenient, the use is convenient, and the safety is high;
1. convenient storage: the medicine core is protected by the medicine coat, so that the contact of the medicine core with air and moisture is reduced;
2. the use is convenient: three kinds of medicines with no quality are distributed in the bottle, and the disintegration speed is higher;
3. the safety is high: the medicine clothes contain the skatole, which emits bad smell and reduces the people from eating by mistake.
Those skilled in the art can operate according to the accompanying instructions without the need for creative efforts of those skilled in the art.
All technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (8)
1. The efficient cyhalothrin is characterized by comprising the following raw materials:
the medicine core is as follows: 0.1-10 parts of efficient cyhalothrin, 1-10 parts of solvent, 1-20 parts of white carbon black, 1-10 parts of emulsifier, 1-10 parts of dispersant, 100 parts of inert filler and 1-5 parts of binder
Coating with a medicine: 10 to 15 percent of gelatin, 1 to 15 percent of plasticizer, 5 to 15 percent of disintegrant, 3 to 10 percent of water, 5 to 15 percent of skatole, 0.1 to 0.3 percent of preservative, 15 to 20 percent of powdery sodium carbonate and 20 to 25 percent of powdery tartaric acid.
2. The cyhalothrin as claimed in claim 1, wherein the emulsifier is one or more of alkylphenol ethoxylates, benzyl phenol polyoxyethylene ether, phenethylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, phenethylphenol polyoxyethylene ether polyoxypropylene ether, fatty amine polyoxyethylene ether, fatty acid and ethylene oxide adduct, castor oil and ethylene oxide adduct and its derivatives, sodium dodecylbenzene sulfonate, calcium dodecylbenzene sulfonate, anionic aryl polyoxyalkyl sulfate, alkyl polyoxyethylene ether, and anionic alkyl sulfonate.
3. The cyhalothrin according to claim 1, wherein the dispersant is selected from one or more of tristyrylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether phosphate, tristyrylphenol polyoxyethylene ether phosphate ammonium salt, naphthalenesulfonate formaldehyde condensate sulfonate, succinic acid sulfonate, sodium lignosulfonate, calcium lignosulfonate, and sodium polycarboxylate.
4. The cyhalothrin of claim 1, wherein the inert material is corn starch.
5. The preparation method of the efficient cyhalothrin is characterized by comprising the following steps:
mixing efficient cyhalothrin, a solvent and an emulsifying machine to form a mixture, pouring white carbon black into the mixture to enable the white carbon black to adsorb the mixture, pouring inert filler into the mixture to uniformly mix to form a semi-finished product, drying the semi-finished product, crushing and grinding the semi-finished product to prepare particles to form a medicine core;
step two, mixing and stirring gelatin, plasticizer and water to prepare capsule material glue solution, then pouring skatole and preservative into the capsule material glue solution for full mixing, then pouring disintegrating agent, powdery morpholine carbonate and powdery tartaric acid into the capsule material glue solution for full mixing, and then shaping the capsule material glue solution to form a capsule coat;
step three, pouring the drug core into the capsule coat, and closing the upper capsule coat and the lower capsule coat to form the drug;
and step four, pouring the medicine into a pesticide bottle quantitatively, and sealing the bottle.
6. The method for preparing lambda-cyhalothrin as claimed in claim 5, wherein the drugs in each bottle are divided into three different mass drugs of small, medium and large, and the capsule coat is engraved with quality parameters.
7. The method of claim 5, wherein the pulverization and grinding processes are performed with a dust removal treatment.
8. The method of claim 5, wherein the core has a ground particle size of less than 4 μm.
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