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CN115475001B - A cryoablation catheter with controllable ablation range - Google Patents

A cryoablation catheter with controllable ablation range

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Publication number
CN115475001B
CN115475001B CN202211117374.2A CN202211117374A CN115475001B CN 115475001 B CN115475001 B CN 115475001B CN 202211117374 A CN202211117374 A CN 202211117374A CN 115475001 B CN115475001 B CN 115475001B
Authority
CN
China
Prior art keywords
balloon
distal end
freezing
rod
ablation range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202211117374.2A
Other languages
Chinese (zh)
Other versions
CN115475001A (en
Inventor
邢宗江
陈智敏
俞鹏
柴凌云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ningbo Senscure Biotechnology Co ltd
Original Assignee
Ningbo Senscure Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Priority to CN202211117374.2A priority Critical patent/CN115475001B/en
Publication of CN115475001A publication Critical patent/CN115475001A/en
Application granted granted Critical
Publication of CN115475001B publication Critical patent/CN115475001B/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00184Moving parts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00214Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022Balloons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00273Anchoring means for temporary attachment of a device to tissue
    • A61B2018/00279Anchoring means for temporary attachment of a device to tissue deployable
    • A61B2018/00285Balloons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00589Coagulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0212Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0231Characteristics of handpieces or probes
    • A61B2018/0262Characteristics of handpieces or probes using a circulating cryogenic fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0293Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument interstitially inserted into the body, e.g. needle

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

The invention discloses a cryoablation catheter with a controllable ablation range, which is characterized in that the effective freezing length (expandable part) of a balloon can be adjusted by limiting the position of a displacement block, namely the displacement block can relatively move on the length of the balloon, the balloon at a shielding part can not be expanded (the expansion of the balloon is limited by the displacement block), the non-shielding part can be normally expanded (after being filled with refrigerant), and the effective ablation range of the cryoballoon can be changed.

Description

Cryoablation catheter with controllable ablation range
Technical Field
The invention relates to the technical field of cryoablation, in particular to a cryoablation catheter with a controllable ablation range.
Background
The natural cavity structure of the human body is utilized, and the minimally invasive surgery is performed under an endoscope, so that the method has the advantages of small trauma, long and short surgery time and high safety. Current treatment modalities are "cold", "hot" ablation modalities, thermal-based treatment modalities such as radio frequency ablation, which, while successful in several fields, have several major drawbacks including incomplete ablation, frequent lack of visualization during catheterization, potential overlap during treatment (where some areas receive twice as much energy as others), charring of tissue, and the need for frequent debridement, among others. Cryoablation treatment refers to a method for inactivating solid tissues in situ by freezing pathological tissues through a low-temperature technology, and the action principle is that the pathological tissues are rapidly cooled by low temperature to destroy cells, so that cell necrosis or apoptosis is caused, and the treatment purpose is achieved. The application of cryoablation in natural lumen passages (NOTES) of human bodies has the advantages of high safety, small irritation and damage to lumen wall tissues, difficult fistula or stenosis and other complications. Cryoablation is used under the guidance of an endoscope, is a minimally invasive treatment mode, and is increasingly used.
Cryoablation is often used extensively in airways, and more indications may be used for cryoablation treatment, such as airway stenosis. Because airway stenosis distributes in the airway and is diversified, the stenosis of a large range circumference or the stenosis of a small range local part is possible, when the cryoballoon carries out cryoablation in the lung, if the cryoballoon ablation range is fixed, the cryoballoon with different models needs to be replaced according to the conditions of different treatment parts in the treatment process, so that the good treatment effect is achieved, the damage to normal tissues is reduced as much as possible, and great inconvenience is brought to clinical operation. In another application scenario in the air flue, the pulmonary vagus nerve is damaged by an interventional cryoablation mode in the air flue (the pulmonary vagus nerve is positioned on the outer side of the air flue wall), the transmission of the vagus nerve is blocked, the secretion of acetylcholine is reduced, the diameter or the length of a lumen in the air flue is different (such as irregular shape or shorter length of a bronchus) due to the difference of human bodies, and when the ablation range (length, circumference or local adjustment) of the cryoballoon is timely adjusted, various differences can be well adapted, the cryoablation can be performed more specifically, and better treatment effect and better safety performance are achieved.
The existing clinical freezing saccule is generally in a fixed ablation range, can not be adjusted in time in the use process, and is inconvenient to use. Therefore, a controlled range of cryoablation techniques is needed to achieve better therapeutic results, simpler clinical procedures, and safer therapeutic methods.
Disclosure of Invention
The invention aims at solving the problems in the prior art and provides a cryoablation catheter with a controllable ablation range.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
The cryoablation catheter with the controllable ablation range comprises a displacement block, a movable rod, a freezing balloon, an air return pipeline, an air inlet pipeline and a handle, wherein the air return pipeline is used for backflow of a refrigerant, the distal end of the air return pipeline is fixedly and hermetically connected with the proximal end of the freezing balloon, the air inlet pipeline is used for inputting the refrigerant, the air inlet pipeline is arranged in the air return pipeline, the distal end of the air return pipeline is arranged in the freezing balloon, the distal end of the displacement block is fixedly connected with the distal end of the movable rod, the movable rod is in sealed and relatively movable connection with the distal end of the freezing balloon, the proximal end of the movable rod is in sealed and relatively movable with an adapter on the air return pipeline, the freezing balloon is in a compressed state of not filled with the refrigerant and in an expanded state of filled with the refrigerant, and the movable rod moves to the proximal end when the freezing balloon is in the compressed state, so that the displacement block relatively moves around the freezing balloon in the compressed state.
Further, an air return pipeline connector is arranged at the proximal end of the air return pipeline, and the air return pipeline connector is fixedly connected with the handle.
Further, an air inlet pipeline connector is arranged at the proximal end of the air inlet pipeline, and the air inlet pipeline connector is fixedly connected with the handle.
Further, a plurality of refrigerant ejection openings are arranged on the pipe wall of the air inlet pipeline, which is positioned on the freezing sacculus part.
Further, the displacement block is a circular tube with a sealed distal end.
Further, the displacement block is a circular tube with a sealed distal end and a hollowed-out wall at a proximal end, and comprises one or more hollowed-out parts, wherein the hollowed-out parts are radially arranged, one end of each hollowed-out part extends to the proximal end of the displacement block, and the width of each hollowed-out part is constant.
Further, the adapter is provided with fixed teeth, the proximal end of the movable rod is provided with a fixed seat, and the fixed teeth and the fixed seat can be meshed with each other.
Further, the movable rod is a tube with a cavity, the part of the distal end of the movable rod in the freezing saccule is a low-hardness section, a shaping rod is arranged in the cavity of the movable rod, the shaping rod and the movable rod can move relatively, the distal end of the shaping rod is a fixed shape part with a preset shape, and the preset shape of the fixed shape part has a bent angle.
Further, the fixed shape part is made of shape memory alloy material.
Compared with the prior art, the invention has the following technical advantages:
According to the invention, through the position limitation of the displacement block, namely the displacement block can relatively move on the length of the balloon, the balloon at the shielding part can not be expanded (the balloon expansion is limited by the displacement block), the non-shielding part can be normally expanded (after being filled with the refrigerant), the effective freezing length (expandable part) of the balloon can be adjusted, and the change of the effective ablation range of the freezing balloon is realized.
The invention can adjust the position of the displacement block by the movement or rotation of the moving rod according to different settings of the shape of the displacement block, and can adjust the effective ablation part of the freezing saccule.
The moving rod is a pipe, the hardness of a section of moving rod in the balloon is reduced, the inner cavity of the moving rod is provided with the shaping rod (with a preset shape at the far end), the shaping rod and the moving rod can move relatively, when the fixed shape part of the shaping rod moves to the low hardness section of the moving rod, the shape of the fixed shape part of the shaping rod can change the shape of the moving rod, so that the shape of the freezing balloon is changed, the angle bending balloon is realized, and the angle bending balloon is suitable for the cryoablation treatment of a specific part of a human body.
Drawings
FIG. 1 is a schematic view of a cryoablation catheter with controlled ablation range in accordance with example 1 of the present invention wherein the cryoballoon is in a short effective cryolength condition.
Fig. 2 is a schematic view of a cryoablation catheter with controlled ablation range in accordance with example 1 of the present invention wherein the cryoballoon is in a long effective cryolength state.
Fig. 3 is a partial schematic view of a cryoablation catheter with controlled ablation range in accordance with example 1 of the present invention.
Fig. 4 is a schematic view of a shift block in embodiment 2 of the present invention.
Fig. 5 is a schematic view of a cryoablation catheter with controlled ablation range in accordance with example 2 of the present invention wherein the cryoballoon is in a short effective cryolength condition.
Fig. 6 is a schematic diagram of a shift block in embodiment 3 of the present invention.
Fig. 7 is a cross-sectional view of the freezing balloon of example 3 of the present invention in an expanded state.
Fig. 8 is a schematic view of a cryoablation catheter with controlled ablation range in accordance with example 4 of the present invention.
Detailed Description
The present invention will be described in detail and specifically by way of the following specific examples and drawings to provide a better understanding of the present invention, but the following examples do not limit the scope of the present invention.
Example 1
Referring to fig. 1 and 2, the embodiment discloses a cryoablation catheter with controllable ablation range, which comprises a displacement block 1, a displacement rod 2, a freezing balloon 3, an air return pipeline 4, an air inlet pipeline 5 and a handle 6, wherein the air return pipeline 4 is used for the backflow of a refrigerant, the distal end of the air return pipeline is fixedly and hermetically connected with the proximal end of the freezing balloon 3, an air return pipeline connector 42 is arranged at the proximal end of the air return pipeline 4, the air return pipeline connector 42 is fixedly connected with the handle 6, the air inlet pipeline 5 is used for the input of the refrigerant and is arranged in the air return pipeline 4, the distal end of the air return pipeline is arranged in the freezing balloon 3, an air inlet pipeline connector 52 is arranged at the proximal end of the air inlet pipeline 5, and the air inlet pipeline connector 52 is fixedly connected with the handle 6;
The distal end of the moving block 1 is fixedly connected with the distal end of the moving rod 2, the moving rod 2 is in sealing and relatively movable connection with the distal end of the freezing balloon 3, the proximal end of the moving rod 2 is in sealing and relatively movable with the adaptor 41 on the return air pipeline 4, the freezing balloon 3 has a compressed state in which no refrigerant is filled and an expanded state in which the refrigerant is filled (the length of the freezing balloon is the effective freezing length at this time), the moving rod 2 moves proximally when the freezing balloon 3 is in the compressed state, the relative position of the moving block 1 and the freezing balloon 3 is adjusted when the periphery of the freezing balloon 3 is in the compressed state, namely, the effective freezing length/ablation range of the freezing balloon 3 is adjusted within a certain range, and the larger the distance between the distal end of the moving block 1 and the distal end of the freezing balloon 3 is, the larger the effective freezing length/ablation range of the freezing balloon 3 is, and the smaller the effective freezing length/ablation range is conversely.
In the invention, the moving rod 2 can be rotated by any angle while moving forwards and backwards, namely, the angle of the moving block 1 is adjusted, the position of the expansion part of the freezing saccule 3 is adjusted, the real-time adjustment of the expansion part of the freezing saccule 3 is realized, the use in the operation process is more convenient, the operation is easy, and the application range is wider.
As a preferred example, the wall of the air intake pipe 5 at the portion of the freezing balloon 3 is provided with a plurality of refrigerant discharge ports 51 for discharging the refrigerant into the freezing balloon 3.
In this embodiment, the displacement block 1 is a tube with a distal end seal.
As a preferred example, referring to fig. 3, the adaptor 41 is provided with a fixing tooth 411, and the proximal end of the moving rod 2 is provided with a fixing seat 21, where the fixing seat 21 can be fixed or moved relative to the moving rod 2 (for example, fixed or moved to the moving rod 2 by screwing or unscrewing). After the position of the movable rod 2 is adjusted, the fixed seat 21 is adjusted to a proper position and fixed, the fixed teeth 411 and the fixed seat 21 are meshed with each other, the fixed teeth 411 can prevent the fixed seat 21 from moving, namely, the movable rod 2 and the movable block1 are blocked from moving, the position of the movable block1 and the shape of the freezing saccule 3 can be better kept, the control of a more accurate freezing saccule ablation range is realized, and the use is more convenient.
Example 2
Referring to fig. 4 and 5, the cryoablation catheter with a controllable ablation range disclosed in this embodiment is different from embodiment 1 in that the displacement block 1 is a hollow circular tube with a distal end sealed and a proximal end wall, and includes a hollow portion 11, where the hollow portion 11 is opened in a radial direction, one end of the hollow portion extends to the proximal end of the displacement block 1, and the width of the hollow portion 11 is constant.
In the embodiment, the hollowed-out part of the displacement block 1 is a half circumference, so that the half circumference of the balloon is partially expanded, and the partial treatment in the cavity is realized. If the lesion in the cavity is a local lesion (non-circumferential lesion), the structure can realize the treatment of the local lesion in the cavity, protect normal tissues as much as possible, achieve the cryoablation treatment effect and reduce the damage of the non-lesion part.
Example 3
Referring to fig. 6 and 7, the cryoablation catheter with a controllable ablation range disclosed in this embodiment is different from embodiment 1 in that the adopted displacement block 1 is a circular tube with a distal end sealed and a proximal end having a hollow tube wall, and includes three hollow portions 11, wherein the hollow portions 11 are opened in a radial direction, one end of each hollow portion extends to the proximal end of the displacement block 1, and the width of each hollow portion 11 is constant.
When the hollowed-out parts 11 of the displacement block 1 are three, the freezing saccule 3 is expanded to be in a three-flap shape, after the refrigerant is filled, only the part of the freezing saccule 3 contacting human tissue is an effective cryoablation area, and when the shape is frozen in the cavity, the freezing saccule 3 can prop up the whole cavity, and only the contact part is the cryoablation area. The cavity is spread, so that the view under the endoscope is clearer (operation view), the operation is convenient, and if the endoscope is used in the airway, the clearance part (non-contact tissue part) can also keep the lung ventilation, so that the patient can not be anoxic in the operation process.
In addition, the hollowed-out parts 11 can be uniformly or unevenly distributed according to the treatment requirement, so that different expansion shapes of the freezing saccule can be formed.
Example 4
Referring to fig. 8, the cryoablation catheter with a controllable ablation range disclosed in this embodiment is different from embodiment 1 in that the moving rod 2 is a tube with a cavity, a portion of the distal end of the moving rod 2 in the cryoballoon 3 is a low-hardness segment 22, a shaping rod 7 is disposed in the cavity of the moving rod 2, the shaping rod 7 and the moving rod 2 can move relatively, and the distal end of the shaping rod 7 is disposed as a predetermined fixed shape portion (such as a predetermined fixed shape made of a shape memory alloy with good elasticity).
When the fixed shape part of the shaping rod 7 moves to the low hardness section 22 of the moving rod 2, the shape of the fixed shape part of the shaping rod 7 can change the shape of the moving rod 2, so as to change the shape of the freezing saccule 3, realize the bending angle freezing saccule which can be bent in an adjustable way, adapt to the cryoablation treatment of specific parts of the human body, such as the left and right main bronchi of the lung, the middle and middle stomach fundus of the stomach or the stomach body part and the top part of a hollow organ (such as the top part of the bladder), and make the cryoablation operation of the specific parts of the human body simpler and more convenient. The angle and radian of the angle freezing saccule can ensure that the contact surface of the freezing saccule and the tissue is larger, the ablation effect is better and more thorough. The shaping rod 7 can also rotate to adjust the bending direction, so that the operation is convenient.
The foregoing description is only illustrative of the preferred embodiments of the present invention and is not to be construed as limiting the scope of the invention, and it will be appreciated by those skilled in the art that equivalent substitutions and obvious variations may be made using the description and illustrations of the present invention, and are intended to be included within the scope of the present invention.

Claims (7)

1. The cryoablation catheter with the controllable ablation range is characterized by comprising a displacement block (1), a movable rod (2), a freezing balloon (3), an air return pipeline (4), an air inlet pipeline (5) and a handle (6), wherein the air return pipeline (4) is used for backflow of a refrigerant, the distal end of the air return pipeline is fixedly and hermetically connected with the proximal end of the freezing balloon (3), the air inlet pipeline (5) is used for inputting the refrigerant, the air inlet pipeline (4) is arranged in the air return pipeline, the distal end of the air inlet pipeline is arranged in the freezing balloon (3), the distal end of the displacement block (1) is fixedly connected with the distal end of the movable rod (2), the movable rod (2) is hermetically and relatively movably connected with the distal end of the freezing balloon (3), the proximal end of the movable rod (2) is hermetically and relatively movably connected with a switching piece (41) on the air return pipeline (4), the freezing balloon (3) is provided with a compressed state of an uninflated refrigerant and a state of an inflated refrigerant, and the balloon is in a compressed state of the freezing balloon (3) when the balloon (3) is in the compressed state and is in the vicinity of the movable rod (3) and is in the compressed state;
The movable rod (2) is a hollow pipe, the part of the distal end of the movable rod (2) in the freezing sacculus (3) is a low-hardness section (22), a shaping rod (7) is arranged in the hollow cavity of the movable rod (2), the shaping rod (7) and the moving rod (2) can move relatively, the distal end of the shaping rod (7) is provided with a preset fixed shape part, and the preset shape of the shaping rod is provided with a bent angle.
2. The cryoablation catheter with controllable ablation range according to claim 1, wherein a return air line connector (42) is provided at the proximal end of the return air line (4), and the return air line connector (42) is fixedly connected with the handle (6).
3. The cryoablation catheter with controllable ablation range according to claim 1, wherein an air inlet pipeline joint (52) is arranged at the proximal end of the air inlet pipeline (5), and the air inlet pipeline joint (52) is fixedly connected with the handle (6).
4. Cryoablation catheter with controllable ablation range according to claim 1, wherein the inlet line (5) is provided with a plurality of refrigerant ejection openings (51) on the wall of the portion of the cryoballoon (3).
5. The cryoablation catheter with controllable ablation range according to claim 1, wherein the displacement block (1) is a distally sealed round tube.
6. The cryoablation catheter with controllable ablation range according to claim 1, wherein the displacement block (1) is a circular tube with a sealed distal end and a hollowed wall at a proximal end, and comprises one or more hollowed parts (11), the hollowed parts (11) are radially opened, one end of each hollowed part extends to the proximal end of the displacement block (1), and the width of each hollowed part (11) is constant.
7. The cryoablation catheter with controllable ablation range according to claim 1, wherein the adapter (41) is provided with fixed teeth (411), the proximal end of the moving rod (2) is provided with a fixed seat (21), and the fixed teeth (411) and the fixed seat (21) can be meshed with each other.
CN202211117374.2A 2022-09-14 2022-09-14 A cryoablation catheter with controllable ablation range Active CN115475001B (en)

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EP4676369A1 (en) 2023-03-03 2026-01-14 Theraheart Inc. Expandable elements for shunting catheters
CN121174997A (en) 2023-04-06 2025-12-19 塞纳医疗公司 Slicing element for shunt catheter
WO2024258474A1 (en) 2023-06-15 2024-12-19 Theraheart Inc. Expandable ablation mechanisms for shunting catheters
US12201354B1 (en) 2024-04-01 2025-01-21 Theraheart Inc. Expandable ablation mechanisms for shunting catheters

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CN217244764U (en) * 2021-09-07 2022-08-23 中国福利会国际和平妇幼保健院 Freezing sacculus suitable for local cryoablation of uterine cavity
CN218651993U (en) * 2022-09-14 2023-03-21 宁波胜杰康生物科技有限公司 Cryoablation catheter with controllable ablation range

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