CN115430341B - Compound omeprazole dry suspension wet preparation device - Google Patents
Compound omeprazole dry suspension wet preparation device Download PDFInfo
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- CN115430341B CN115430341B CN202211272776.XA CN202211272776A CN115430341B CN 115430341 B CN115430341 B CN 115430341B CN 202211272776 A CN202211272776 A CN 202211272776A CN 115430341 B CN115430341 B CN 115430341B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
- B01F33/833—Devices with several tools rotating about different axis in the same receptacle
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
- B01F27/191—Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/808—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with stirrers driven from the bottom of the receptacle
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
- B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
- B01F33/83611—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by cutting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/11—Maintenance of mixers using fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/12—Maintenance of mixers using mechanical means
- B01F35/121—Maintenance of mixers using mechanical means using a brush for cleaning out rests of products
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/12—Maintenance of mixers using mechanical means
- B01F35/123—Maintenance of mixers using mechanical means using scrapers for cleaning mixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Accessories For Mixers (AREA)
Abstract
本发明涉及药物制备装置技术领域，尤其涉及一种复方奥美拉唑干混悬剂湿法制备装置，包括壳体、搅拌电机、搅拌轴、搅拌杆和刷除机构；所述刷除机构能够将粘连在搅拌轴、搅拌杆以及制粒刀上的原料刷下；本发明通过在壳体内设置刷除机构，在壳体内的搅拌轴和搅拌杆以及制粒刀上粘附有奥美拉唑原料粉末和辅助剂的混合物时对其进行清理，从而防止奥美拉唑原料粉末和辅助剂的混合物残留在壳体内，一方面防止后续工作人员清理时搅拌轴、搅拌杆和制粒刀上粘附的奥美拉唑原料粉末和辅助剂的混合物不方便清理而残留，污染壳体内的洁净环境，另一方面使得工作人员不必人工清理搅拌轴、搅拌杆和制粒刀等不方便清理的部分，降低了工作人员的劳动强度。
The invention relates to the technical field of drug preparation devices, and in particular to a wet method preparation device for compound omeprazole dry suspension, comprising a shell, a stirring motor, a stirring shaft, a stirring rod and a brushing mechanism; the brushing mechanism can brush off raw materials adhered to the stirring shaft, the stirring rod and a granulating knife; the invention arranges the brushing mechanism in the shell to clean the mixture of omeprazole raw material powder and auxiliary agent when the mixture adheres to the stirring shaft, the stirring rod and the granulating knife in the shell, thereby preventing the mixture of omeprazole raw material powder and auxiliary agent from remaining in the shell. On the one hand, it is prevented that the mixture of omeprazole raw material powder and auxiliary agent adhered to the stirring shaft, the stirring rod and the granulating knife during subsequent cleaning is inconvenient to clean and remains, thereby polluting the clean environment in the shell; on the other hand, it is unnecessary for the staff to manually clean the parts such as the stirring shaft, the stirring rod and the granulating knife that are inconvenient to clean, thereby reducing the labor intensity of the staff.
Description
Technical Field
The invention relates to the technical field of medicine preparation devices, in particular to a wet preparation device for a compound omeprazole dry suspension.
Background
Omeprazole is used for treating peptic ulcer and other diseases, and has strong and durable inhibition effect on gastric acid secretion caused by various reasons; the dry suspension is a liquid preparation in which the insoluble medicine and proper auxiliary materials are prepared into powder or granules, and the powder or the granules can be dispersed into suspension for oral administration by adding water and stirring when the dry suspension is taken, and the preparation process of the dry suspension can be granulating or not granulating;
In the process of preparing the compound omeprazole dry suspension by adopting a wet method, devices such as a wet method granulator, a groove-shaped mixer and the like are needed to be used in the preparation equipment, wherein in the process of granulating by the wet method granulator, the inner edge position of the granulator has the condition of accumulating materials, various wet method granulation equipment in the prior art solves the problem, for example, the invention patent with the application number of CN201810141720.8 uses a connecting rod to drive a scraper to rotate in the wet method granulator, and scrapes the inner wall of the wet method granulator to reduce the accumulating materials; however, the technical scheme has certain defects, and when the wet granulator is used, raw material powder is adhered to the connecting rod and the granulating cutter after the mixing agent is mixed, and the connecting rod for stirring raw materials and the raw materials adhered to the granulating cutter are difficult to clean by the existing wet granulator.
Therefore, we propose a wet preparation device for compound omeprazole dry suspension.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a wet preparation device for a compound omeprazole dry suspension, which overcomes the defects of the prior art and aims at solving the problems in the background art.
In order to achieve the above purpose, the present invention provides the following technical solutions: a wet preparation device for compound omeprazole dry suspension comprises
A housing and a stirring motor; the stirring motor is fixedly connected below the shell, the output shaft is rotationally connected with the shell, and the stirring shaft is fixedly connected on the output shaft of the stirring motor; stirring rods are uniformly and fixedly connected to the stirring shaft;
a cutting motor; the output shaft of the cutting motor is fixedly connected with a granulating cutter;
A controller;
a brushing mechanism is arranged in the shell; the brushing mechanism can brush down raw materials adhered to the stirring shaft, the stirring rod and the granulating knife.
Preferably, the brushing mechanism comprises a first mounting groove, a second mounting groove, a first electric push rod, a second electric push rod, a first cleaning block and a second cleaning block;
The first mounting groove and the second mounting groove are both formed in the inner wall of the shell, and a first sliding rail is fixedly connected in the first mounting groove; the first sliding rail is connected with a first sliding block in a sliding manner; a driving motor and a screw rod are fixedly connected in the first mounting groove; the output end of the driving motor is fixedly connected with the screw rod; the screw rod is in threaded fit with the sliding block; the first electric push rod is fixedly connected to the sliding block, and the output end of the first electric push rod is connected with the first cleaning block; the first cleaning block is square in shape, and a hard brush is fixedly connected to the outer surface of the first cleaning block;
The second electric push rod is fixedly connected in the second mounting groove, and the output end of the second electric push rod is connected with the second cleaning block; the shape of the second cleaning block is 匚 and the opening faces the granulating knife, and a hard brush is fixedly connected to the inner wall of the second cleaning block.
Preferably, the first mounting groove and the second mounting groove are fixedly connected with a third electric push rod and a telescopic rod; the output end of the third electric push rod in the first mounting groove and the telescopic rod are connected with the same first plugging block in a common rotation mode; the output end of the third electric push rod in the second mounting groove and the telescopic rod are connected with the same second plugging block in a common rotation mode.
Through setting up the mechanism of brushing off in the casing, clear up the (mixing) shaft in the casing and puddler and pelletization sword when the adhesion has the mixture of omeprazole raw materials powder and auxiliary agent to prevent that the mixture of omeprazole raw materials powder and auxiliary agent from remaining in the casing, on the one hand prevent inconvenient clearance of the mixture of omeprazole raw materials powder and auxiliary agent of adhesion on puddler, puddler and the pelletization sword and remaining when follow-up staff clear up, pollute the clean environment in the casing, on the other hand make the staff unnecessary the part of inconvenient clearance such as manual work clearance puddler, puddler and pelletization sword, reduced staff's intensity of labour.
Preferably, the first electric push rod is connected with the first cleaning block through a first scissors fork structural member; two ends of the first shearing fork structural member are hinged with the sliding block and the first cleaning block respectively; the output end of the first electric push rod is fixedly connected with a cross rod; the two ends of the cross rod are rotationally connected with the first scissors fork structural member; the second electric push rod is connected with the second cleaning block through a second shear fork structural member; the two ends of the second shear fork structural member are respectively and rotatably connected with the second cleaning block and the inner wall of the second mounting groove; the output end of the second electric push rod is fixedly connected with a cross rod; the cross rod is rotationally connected with the second scissors fork structural member.
Preferably, the end surfaces of the first cleaning block and the second cleaning block, which are provided with the hard hairbrushes, are provided with air vents; the first cleaning block and the second cleaning block are fixedly connected with communicating pipes; the communicating pipe is communicated with the corresponding air vent.
The distance between the first cleaning block and the second cleaning block is prolonged by using the scissors structure, so that the first electric push rod and the second electric push rod are not required to have longer telescopic distances, the sizes of the first electric push rod and the second electric push rod are reduced, and the first electric push rod and the second electric push rod can be suitable for being arranged in the first mounting groove and the second mounting groove; and meanwhile, when the hard brush is cleaned, air is blown out from the air vent, so that the cleaning effect is enhanced, and the mixture of omeprazole raw material powder and auxiliary agent is prevented from adhering to the hard brush.
Preferably, a scraping rod is arranged in the shell; the scraping rod can scrape the inner wall of the shell; the inner wall of the shell is provided with a containing groove; a fourth electric push rod is fixedly connected in the accommodating groove; the end part of the output end of the fourth electric push rod is in a Chinese character 'zhong'; a first groove corresponding to the fourth electric push rod is formed in the side edge of the scraping rod; the lower end of the stirring shaft is square; the lower end of the scraping rod is provided with a square slot which can be clamped with the stirring shaft.
Preferably, the accommodating groove is fixedly connected with a telescopic spring; the other end of the telescopic spring is fixedly connected with a third plugging block; the third plugging block is in sliding connection with the accommodating groove; in the initial state, the scraping rod extrudes the third plugging block and the telescopic spring, and the scraping rod plugs the notch of the containing groove.
Preferably, the stirring rod is elliptical.
The invention has the beneficial effects that:
1. According to the invention, the brushing mechanism is arranged in the shell, and the mixture of the omeprazole raw material powder and the auxiliary agent is cleaned when the mixture of the omeprazole raw material powder and the auxiliary agent is adhered to the stirring shaft and the stirring rod in the shell and the granulating knife in the shell, so that the mixture of the omeprazole raw material powder and the auxiliary agent is prevented from remaining in the shell, the mixture of the omeprazole raw material powder and the auxiliary agent adhered to the stirring shaft, the stirring rod and the granulating knife is prevented from being inconvenient to clean and remaining when a subsequent worker cleans, the clean environment in the shell is polluted, and the labor intensity of the worker is reduced because the worker does not need to manually clean the parts such as the stirring shaft, the stirring rod and the granulating knife.
2. According to the invention, the distance between the first cleaning block and the second cleaning block is prolonged by using the scissors structure, so that the first electric push rod and the second electric push rod do not need to have longer telescopic distance, the sizes of the first electric push rod and the second electric push rod are reduced, and the first electric push rod and the second electric push rod can be suitable for being arranged in the first mounting groove and the second mounting groove; and meanwhile, when the hard brush is cleaned, air is blown out from the air vent, so that the cleaning effect is enhanced, and the mixture of omeprazole raw material powder and auxiliary agent is prevented from adhering to the hard brush.
Drawings
FIG. 1 is a schematic view of the internal structure of the present invention;
FIG. 2 is a schematic view of the internal structure of another cross-sectional view of the present invention;
FIG. 3 is an enlarged view of FIG. 2 at A;
FIG. 4 is an enlarged view at B in FIG. 2;
FIG. 5 is an enlarged view at C in FIG. 2;
FIG. 6 is a partial cross-sectional view of the present invention between a first mounting groove, a first scissors structure and a third electric putter, and a telescoping rod;
fig. 7 is a partial cross-sectional view of a second scissors assembly, a second cleaning block, a third electric putter and a telescoping rod of the present invention.
In the figure: 1. a housing; 2. a scraping rod; 3. a stirring motor; 31. a stirring shaft; 32. a stirring rod; 4. a cutting motor; 41. a granulating knife; 5. a brushing mechanism; 51. a first mounting groove; 52. a second mounting groove; 53. a first electric push rod; 54. a second electric push rod; 55. a first cleaning block; 56. a second cleaning block; 57. a first slide rail; 58. a first sliding block; 59. a telescopic electric push rod; 6. a third electric push rod; 61. a telescopic rod; 62. a first plugging block; 63. a second plugging block; 7. a first scissors fork structure; 71. a cross bar; 72. a second scissors fork structural member; 73. a vent; 74. a communicating pipe; 8. a receiving groove; 81. fourth electric push rod; 82. a first groove; 83. a square opening groove; 84. a telescopic spring; 85. and a third plugging block.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Embodiment one:
referring to figure 1 of the specification, a wet preparation device for compound omeprazole dry suspension comprises
A housing 1 and a stirring motor 3; the stirring motor 3 is fixedly connected below the shell 1, an output shaft is rotationally connected with the shell 1, and a stirring shaft 31 is fixedly connected to the output shaft of the stirring motor 3; the stirring shaft 31 is uniformly and fixedly connected with stirring rods 32;
A cutting motor 4; the cutting motor 4 is fixedly connected above the shell 1, and a granulating cutter 41 is fixedly connected on an output shaft of the cutting motor 4;
A controller;
A brushing mechanism 5 is arranged in the shell 1; the brush-removing mechanism 5 is capable of brushing off the raw materials adhered to the stirring shaft 31, the stirring rod 32, and the granulating blade 41.
Referring to fig. 2 of the specification and fig. 3 of the specification, in the present embodiment, the brush-out mechanism 5 includes a first mounting groove 51, a second mounting groove 52, a first electric putter 53, a second electric putter 54, a first cleaning block 55, and a second cleaning block 56;
the first mounting groove 51 and the second mounting groove 52 are formed in the inner wall of the shell 1, and a first sliding rail 57 is fixedly connected in the first mounting groove 51; the first slide rail 57 is slidably connected with a first slide block 58; a driving motor and a screw rod are fixedly connected in the first mounting groove 51; the output end of the driving motor is fixedly connected with the screw rod; the screw rod is in threaded fit with the sliding block; the first electric push rod 53 is fixedly connected to the sliding block, and the output end of the first electric push rod 53 is connected with the first cleaning block 55; the first cleaning block 55 is square in shape and is fixedly connected with a hard brush on the outer surface;
the second electric push rod 54 is fixedly connected in the second mounting groove 52, and the output end of the second electric push rod 54 is connected with the second cleaning block 56; the second cleaning block 56 is 匚 -shaped and has an opening facing the granulating blade 41, and a hard brush is fixedly connected to the inner wall of the second cleaning block 56.
Referring to fig. 6 and 7 of the specification, in this embodiment, a first mounting groove 51 and a second mounting groove 52 are respectively and fixedly connected with a third electric push rod 6 and a telescopic rod 61; the output end of the third electric push rod 6 in the first mounting groove 51 and the telescopic rod 61 are connected with the same first plugging block 62 in a rotation mode; the output end of the third electric push rod 6 in the second mounting groove 52 and the telescopic rod 61 are connected with the same second plugging block 63 in a co-rotation mode.
When the compound omeprazole dry suspension is prepared by a wet method, a worker pours omeprazole raw material powder and an auxiliary agent into a shell 1, then starts a stirring motor 3 through a controller, so that the stirring motor 3 drives a stirring shaft 31 and a stirring rod 32 to rotate, and the omeprazole raw material powder and the auxiliary agent in the shell 1 are stirred, the stirring motor 3 is stopped after stirring is completed, and then a cutting motor 4 is started to rotate with a granulating cutter 41 for granulating;
After the granulation is completed, when the mixture of the residual omeprazole raw material and the auxiliary machine is adhered to the stirring shaft 31, the stirring rod 32 and the granulating knife 41, a worker controls the output end of the third electric push rod 6 to extend through a controller, so that the output end of the third electric push rod 6 pushes the first plugging block 62, one end of the first plugging block 62 pulls the telescopic rod 61 to move forwards, when the telescopic rod 61 is pulled down to a limit length, the top end of the telescopic rod 61 is fixed, at the moment, the first plugging block 62 deflects around the top end of the telescopic rod 61 under the thrust action of the third electric push rod 6, so that the notch of the first mounting groove 51 is exposed, then the controller controls the output end of the first electric push rod 53 to extend, the first cleaning block 55 moves towards the direction close to the stirring shaft 31 and the stirring rod 32, the first cleaning block 55 is positioned below the first stirring rod 32, the hard brush on the upper side of the first cleaning block 55 is contacted with the lower surface of the first stirring rod 32, the hard brush 31 on the side of the first cleaning block 55 is contacted with the stirring shaft 31, then the motor controls the brush 31 on the second stirring rod 31, the brush 55 is rotated to rotate the second stirring rod 31, and the second cleaning block 55 is positioned on the stirring rod 32, and the other side of the first brush 55 is contacted with the stirring rod 31 on the stirring rod 31, and the other end of the first cleaning block is simultaneously, and the second stirring rod is rotated to finish the stirring rod is positioned on the stirring rod 31;
After the lower surface of the last stirring rod 32 is cleaned, the controller controls the output end of the first electric push rod 53 to shrink, so that the first cleaning block 55 moves in a direction away from the rotating shaft, then the controller controls the driving motor to rotate, so that the screw rod and the part in threaded fit with the first sliding block 58 move, so that the first sliding block 58 moves upwards with the first electric push rod 53 and the first cleaning block 55, then the controller controls the output end of the first electric push rod 53 to stretch out again, so that the first cleaning block 55 stretches into a position between the last stirring rod 32 and the last stirring rod 32, the controller controls the stirring motor 3 to rotate with the stirring shaft 31 and the stirring rod 32 again, so that the first cleaning block 55 cleans the upper surface of the last stirring rod 32, the lower surface of the last stirring rod 32 and the stirring shaft 31 of the part, and after the cleaning, the stirring rod 32 and the stirring shaft 31 of the part above the last stirring rod 32 are cleaned by the method until the cleaning is completed;
While cleaning the stirring shaft 31 and the stirring rod 32, the controller controls the third electric push rod 6 in the second mounting groove 52 to extend, so that the second plugging block 63 deflects in the same way as the first plugging block 62, the notch of the second mounting groove 52 is exposed, the controller controls the output end of the second electric push rod 54 to extend, so that the second cleaning block 56 moves towards the direction close to the granulating blade 41 until the hard brush in the second cleaning block 56 contacts with the upper surface and the lower surface of the granulating blade 41, at the moment, the controller controls the cutting motor 4 to slowly rotate in the opposite direction of the granulating blade 41, at the moment, the hard brush in the second cleaning block 56 brushes the upper surface and the lower surface of the granulating blade 41, so that the mixture of omeprazole raw material powder and auxiliary agent adhered on the upper surface and the lower surface of the granulating blade 41 brushes away from the granulating blade 41, and then the controller controls the output end of the second electric push rod 54 to retract, so that the hard brush in the second cleaning block 56 returns to the second mounting groove 52; since the granulating blade 41 is in the opposite direction when rotating, the back of the granulating blade 41 is in the front, and the blade rotates in the rear, the condition that the granulating blade 41 cuts a hard brush can not occur; after the mixture of omeprazole raw material powder and auxiliary agent adhered on the stirring shaft 31, the stirring rod 32 and the granulating blade 41 is cleaned, the output ends of the electric push rods No. three 6 in the installation grooves No. 51 and No. two 52 are retracted by the controller, so that the blocking blocks No. 62 and No. two 63 move towards the corresponding installation grooves No. one 51 and No. two 52, the telescopic rod 61 is contracted, after the telescopic rod 61 is contracted, the blocking blocks No. 62 and No. two 63 deflect under the action of the corresponding electric push rods No. three 6, the deflection direction is opposite to the previous direction, and the blocking blocks No. 62 and No. two 63 block the corresponding notch of the installation grooves No. one 51 and No. two 52 again;
According to the invention, the brush removing mechanism 5 is arranged in the shell 1, and the mixture of the omeprazole raw material powder and the auxiliary agent is cleaned when the stirring shaft 31 and the stirring rod 32 in the shell 1 and the granulating blade 41 are adhered, so that the mixture of the omeprazole raw material powder and the auxiliary agent is prevented from remaining in the shell 1, the mixture of the omeprazole raw material powder and the auxiliary agent adhered on the stirring shaft 31, the stirring rod 32 and the granulating blade 41 is prevented from being inconvenient to clean and remaining when a subsequent worker cleans, the clean environment in the shell 1 is polluted, and on the other hand, the workers do not need to manually clean the parts of the stirring shaft 31, the stirring rod 32, the granulating blade 41 and the like, so that the labor intensity of the workers is reduced.
Referring to fig. 3 of the specification, in this embodiment, a first electric push rod 53 and a first cleaning block 55 are connected through a first scissors structure 7; two ends of the first shearing fork structural member 7 are hinged with the sliding block and the first cleaning block 55 respectively; the output end of the first electric push rod 53 is fixedly connected with a cross rod 71; two ends of the cross rod 71 are rotatably connected with the first scissors structure 7; the second electric push rod 54 is connected with the second cleaning block 56 through a second shear fork structural member 72; two ends of the second shearing fork structural member 72 are respectively and rotatably connected with the second cleaning block 56 and the inner wall of the second mounting groove 52; the output end of the second electric push rod 54 is fixedly connected with a cross rod 71; the cross bar 71 is rotatably connected to a second scissors structure 72.
Referring to fig. 3 and 7 of the drawings, in this embodiment, the end surfaces of the first cleaning block 55 and the second cleaning block 56 provided with the hard brush are provided with air vents 73; the first cleaning block 55 and the second cleaning block 56 are fixedly connected with a communicating pipe 74; the communication pipe 74 communicates with the corresponding vent 73.
Because the first mounting groove 51 and the second mounting groove 52 are formed in the shell 1, and the first electric push rod 53 and the second electric push rod 54 are positioned in the first mounting groove 51 and the second mounting groove 52, the sizes of the first electric push rod 53 and the second electric push rod 54 cannot exceed the thickness of the shell 1, if the embodiment that the output end of the first electric push rod 53 is directly fixedly connected with the first cleaning block 55 and the output end of the second electric push rod 54 is directly fixedly connected with the second cleaning block 56 is adopted, the extending distance of the first cleaning block 55 and the second cleaning block 56 is difficult to contact with the stirring shaft 31, the stirring rod 32 and the granulating cutter 41;
Therefore, in this embodiment, the output ends of the first electric push rod 53 and the second electric push rod 54 are respectively connected with the first cleaning block 55 and the second cleaning block 56 through the first shearing fork structural member 7 and the second shearing fork structural member 72, and when the output end of the first electric push rod 53 extends, the output end of the first electric push rod 53 pushes the corresponding cross rod 71, so that the cross rod 71 pushes the first shearing fork structural member 7, and therefore one end of the first shearing fork structural member 7 away from the first electric push rod 53 extends to push the first cleaning block 55 to move forward; because of the special structure of the first shearing insert, the first shearing insert drives the first cleaning block 55 to move far beyond the length of the output end of the first electric push rod 53, so that the hard brush on the first cleaning block 55 can be in contact with the stirring shaft 31; similarly, when the output end of the second electric push rod 54 extends, the second shear insert pushes the second cleaning block 56 in the same manner;
In this embodiment, when the first cleaning block 55 and the second cleaning block 56 clean the stirring rod 32, the stirring shaft 31 and the granulating blade 41, air flow can be introduced into the communicating pipe 74 to be sprayed out from the air vent 73, so that the air flow is blown onto the hard brush and the corresponding stirring rod 32, stirring shaft 31 and hard brush, and the mixture of omeprazole raw material powder and auxiliary agent can be prevented from adhering to the hard brush, and the cleaning effect of the hard brush is increased;
the invention uses the scissors structure to prolong the distance between the first cleaning block 55 and the second cleaning block 56, so that the first electric push rod 53 and the second electric push rod 54 do not need to have longer telescopic distance, the sizes of the first electric push rod 53 and the second electric push rod 54 are reduced, and the first electric push rod 53 and the second electric push rod 54 can be applicable to the first mounting groove 51 and the second mounting groove 52; while blowing out the air from the air vent 73 at the time of cleaning of the hard brush, not only enhances the cleaning effect, but also prevents the mixture of omeprazole raw material powder and adjuvant from adhering to the hard brush.
Embodiment two:
On the basis of the first embodiment, referring to fig. 2, 4 and 5 of the specification, in this embodiment, a scraping rod 2 is disposed in a housing 1; the scraping rod 2 can scrape the inner wall of the shell 1; the inner wall of the shell 1 is provided with a containing groove 8; a fourth electric push rod 81 is fixedly connected in the accommodating groove 8; the end part of the output end of the fourth electric push rod 81 is in a Chinese character 'zhong'; a first groove 82 corresponding to the fourth electric push rod 81 is formed in the side edge of the scraping rod 2; the lower end of the stirring shaft 31 is square; the lower end of the scraper bar 2 is provided with a square slot 83 which can be engaged with the stirring shaft 31.
In the embodiment, a telescopic spring 84 is fixedly connected in the accommodating groove 8; the other end of the telescopic spring 84 is fixedly connected with a third plugging block 85; the third plugging block 85 is in sliding connection with the accommodating groove 8; in the initial state, the scraping rod 2 presses the third plugging block 85 and the telescopic spring 84, and the scraping rod 2 plugs the notch of the accommodating groove 8.
In this embodiment, when the mixture of the omeprazole powder and the adjuvant is adhered to the inner wall of the shell 1, the controller controls the fourth electric push rod 81 to push the scraper 2 to move towards the direction close to the stirring shaft 31, so that the square slot 83 at the lower end of the scraper 2 is engaged with the square lower end of the stirring shaft 31, at this time, the scraper 2 slides out of the accommodating slot 8, then the controller controls the stirring motor 3 to rotate with the stirring shaft 31 and the scraper 2, the output end of the fourth electric push rod 81 is separated from the first slot 82 on the scraper 2, the scraper 2 rotates against the inner wall of the shell 1, and the mixture of the omeprazole powder and the adjuvant adhered to the inner wall of the shell 1 is scraped; when the scraping rod 2 needs to be retracted into the accommodating groove 8, the rotating shaft drives the scraping rod 2 to rotate to the position of the fourth electric push rod 81, the first groove 82 on the scraping rod 2 is clamped with the output end of the fourth electric push rod 81 in a shape, then the controller controls the output end of the fourth electric push rod 81 to retract, and drives the scraping rod 2 to move, so that the scraping rod 2 reenters the accommodating groove 8, and the lower end of the scraping rod 2 is separated from the stirring shaft 31;
In this embodiment, the expansion spring 84 and the third plugging block 85 are disposed in the accommodating groove 8, so that when the scraping rod 2 moves out of the accommodating groove 8 and is clamped with the rotating shaft, the third plugging block 85 plugs the notch of the accommodating groove 8 under the action of the expansion spring 84, and prevents the mixture of omeprazole raw material powder and auxiliary agent scraped from the inner wall of the shell 1 from entering the accommodating groove 8; when the scraper bar 2 returns to the accommodating groove 8, the scraper bar 2 presses the third plugging block 85 and the extension spring 84 inward, returns to the accommodating groove 8, and the scraper bar 2 plugs the notch of the accommodating groove 8.
Referring to fig. 1 of the drawings, in this embodiment, the stirring rod 32 has an elliptical shape.
In this embodiment, the stirring rod 32 is set to be oval, and the oval long axis is transversely set, compared with the round stirring rod 32, the oval stirring rod 32 is flat, so that the overall thickness of the stirring rod 32 is reduced, the upper surface and the lower surface of the stirring rod 32 are more gentle, the contact degree of the stirring rod 32 and the hard brush is increased, and the cleaning effect of the mixture of omeprazole raw material powder and auxiliary agent adhered on the stirring rod 32 is improved.
The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made therein without departing from the spirit and scope of the invention, which is defined by the appended claims; the scope of the invention is defined by the appended claims and equivalents thereof.
Claims (6)
1. A wet preparation device for compound omeprazole dry suspension comprises
Comprises a shell (1), a stirring motor (3), a stirring shaft (31) and a stirring rod (32); a cutting motor (4) and a granulating knife (41);
A controller;
the method is characterized in that: a brushing mechanism (5) is arranged in the shell (1); the brushing mechanism (5) can brush down raw materials adhered to the stirring shaft (31), the stirring rod (32) and the granulating knife (41);
A scraping rod (2) is arranged in the shell (1); the scraping rod (2) can scrape the inner wall of the shell (1); an accommodating groove (8) is formed in the inner wall of the shell (1); a fourth electric push rod (81) is fixedly connected in the accommodating groove (8); the end part of the output end of the fourth electric push rod (81) is in a Chinese character 'zhong'; a first groove (82) corresponding to the fourth electric push rod (81) is formed in the side edge of the scraping rod (2); the lower end of the stirring shaft (31) is square; a square opening groove (83) which can be clamped with the stirring shaft (31) is formed in the lower end of the scraping rod (2), and a telescopic spring (84) is fixedly connected in the accommodating groove (8); the other end of the telescopic spring (84) is fixedly connected with a third plugging block (85); the third plugging block (85) is in sliding connection with the accommodating groove (8); in an initial state, the scraping rod (2) extrudes the third plugging block (85) and the telescopic spring (84), and the scraping rod (2) plugs the notch of the accommodating groove (8).
2. The wet preparation device for the compound omeprazole dry suspension agent of claim 1, which is characterized in that: the brushing mechanism (5) comprises a first mounting groove (51), a second mounting groove (52), a first electric push rod (53), a second electric push rod (54), a first cleaning block (55) and a second cleaning block (56);
The first mounting groove (51) and the second mounting groove (52) are formed in the inner wall of the shell (1), and a first sliding rail (57) is fixedly connected in the first mounting groove (51); the first sliding rail (57) is connected with a first sliding block (58) in a sliding manner; a driving motor and a screw rod are fixedly connected in the first mounting groove (51); the output end of the driving motor is fixedly connected with the screw rod; the screw rod is in threaded fit with the sliding block; the first electric push rod (53) is fixedly connected to the sliding block, and the output end of the first electric push rod (53) is connected with the first cleaning block (55); the first cleaning block (55) is square in shape, and a hard brush is fixedly connected to the outer surface of the first cleaning block;
The second electric push rod (54) is fixedly connected in the second mounting groove (52), and the output end of the second electric push rod (54) is connected with the second cleaning block (56); the shape of No. two clearance piece (56) is 匚 shapes and opening orientation pelletization sword (41), link firmly the stereoplasm brush on the inner wall of No. two clearance piece (56), the controller again controls driving motor and takes the lead screw rotation, thereby the part of screw thread cooperation between lead screw and No. one slider (58) makes No. one slider (58) remove, thereby No. one slider (58) takes electric putter (53) and No. one clearance piece (55) upwards, then the output of controller control No. one electric putter (53) stretches out again, make No. one clearance piece (55) stretch into the position between last puddler (32) and last puddler (32), the controller again controls agitator motor (3) and takes (31) and puddler (32) rotation, thereby No. one clearance piece (55) again carries out clearance to last surface and last one puddler (32) lower surface and stirring axle (31) of this part of last one puddler (32), with the method again is accomplished after last one puddler (32) is again, this part of clearance is accomplished with last one again.
3. The wet preparation device for the compound omeprazole dry suspension agent of claim 2, which is characterized in that: a third electric push rod (6) and a telescopic rod (61) are fixedly connected in the first mounting groove (51) and the second mounting groove (52); the output end of the third electric push rod (6) in the first mounting groove (51) and the telescopic rod (61) are connected with the same first plugging block (62) in a common rotation mode; the output end of the third electric push rod (6) in the second mounting groove (52) and the telescopic rod (61) are connected with the same second blocking block (63) in a co-rotation mode, the output end of the third electric push rod is controlled by the controller to extend out, so that the output end of the third electric push rod pushes the first blocking block (62), one end of the telescopic rod is pulled to move forwards by the first blocking block (62), after the telescopic rod is pulled to the limit length, the top end of the telescopic rod is fixed, at the moment, the first blocking block (62) deflects around the top end of the telescopic rod under the thrust action of the third electric push rod, and a notch of the first mounting groove (51) is exposed;
The controller controls the third electric push rod in the second mounting groove (52) to extend out, so that the second plugging block (63) deflects in the same way as the first plugging block (62), and the notch of the second mounting groove (52) is exposed.
4. The wet preparation device for the compound omeprazole dry suspension agent of claim 2, which is characterized in that: the first electric push rod (53) is connected with the first cleaning block (55) through a first scissors fork structural member (7); two ends of the first shearing fork structural member (7) are hinged with the sliding block and the first cleaning block (55) respectively; the output end of the first electric push rod (53) is fixedly connected with a cross rod (71); the two ends of the cross rod (71) are rotationally connected with the first shearing fork structural member (7); the second electric push rod (54) is connected with the second cleaning block (56) through a second shear fork structural member (72); two ends of the second shear fork structural member (72) are respectively and rotatably connected with the inner walls of the second cleaning block (56) and the second mounting groove (52); the output end of the second electric push rod (54) is fixedly connected with a cross rod (71); the cross rod (71) is rotatably connected with the second scissors structure (72).
5. The wet preparation device for the compound omeprazole dry suspension agent of claim 2, which is characterized in that: the end surfaces of the first cleaning block (55) and the second cleaning block (56) provided with the hard hairbrushes are provided with air vents (73); a communicating pipe (74) is fixedly connected to the first cleaning block (55) and the second cleaning block (56); the communication pipe (74) communicates with the corresponding vent port (73).
6. The wet preparation device for the compound omeprazole dry suspension agent of claim 2, which is characterized in that: the stirring rod (32) is elliptical.
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| CN202211272776.XA CN115430341B (en) | 2022-10-18 | 2022-10-18 | Compound omeprazole dry suspension wet preparation device |
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| CN202211272776.XA CN115430341B (en) | 2022-10-18 | 2022-10-18 | Compound omeprazole dry suspension wet preparation device |
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| CN116875428B (en) * | 2023-03-23 | 2024-03-19 | 枣庄市杰诺生物酶有限公司 | Fermentation purification preparation equipment and method for L-leucine |
| CN118021615B (en) * | 2024-04-15 | 2024-06-18 | 山西旺龙药业集团有限公司 | Wet granulation device for Sanhuang tablets and preparation method thereof |
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| DE202015101944U1 (en) * | 2015-04-20 | 2015-07-27 | Günther Noelle | Cleaning device for stirring shafts |
| CN207343316U (en) * | 2017-10-12 | 2018-05-11 | 山东润涵新材料科技有限公司 | Dispersion machine stirring system cleaning case |
| CN112675733A (en) * | 2020-12-03 | 2021-04-20 | 河北化工医药职业技术学院 | Raw material stirring device for chemical production |
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| CN211806959U (en) * | 2019-09-24 | 2020-10-30 | 江苏李文甲化工有限公司 | Environment-friendly acrylate emulsion cement mortar preparation is with mixer |
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