CN115382080A - Catheter with pressure measuring function, intracavity treatment catheter and intelligent intracavity treatment device - Google Patents

Abstract

Catheter with pressure measurement function, intracavitary therapy catheter and intelligent intracavitary therapy device, the catheter body is equipped with at least one pressure sensor, and its pressure sensing unit includes at least a sensitive element and at least two sensor tail wires. The sensitive element is set on The outer surface of the catheter body forms a columnar space. The sensor tail wire is arranged on the outer surface of the catheter body or protrudes into the catheter lumen. The sensor tail wires are respectively installed with the sensitive elements, and the installation position should be located at the In the columnar space of the sensitive element, the pressure sensor senses the radial force and/or frictional force exerted by the tissue on the surface of the catheter body, and/or the axial force exerted on the catheter tip, and sends the pressure information through the signal processing unit transmitted to the outside of the catheter. The size of the conduit with pressure measurement function of the present invention is controllable, and a pressure sensor that meets the size requirements can be adapted according to the size of the conduit, and the requirements of compact structure and small space for the conduit with pressure measurement function can be met.

Description

Catheters with Manometry, Endoluminal Therapy Catheters and Smart Endoluminal Therapy Devices

technical field

The invention relates to the field of medical instruments, in particular to a catheter with pressure measurement function, an intracavity treatment catheter and an intelligent intracavity treatment device.

Background technique

Minimally invasive interventional surgery is becoming a widely used method in the field of medical device treatment, so the application of corresponding interventional catheters is becoming more and more frequent. When the catheter travels or diagnoses in the human cavity, it will contact the inner surface tissue of the human cavity. The contact force will often affect the treatment process or treatment effect. For some processes, excessive contact force will damage normal tissues. In other processes If the contact force is too small, the therapeutic effect may not be achieved. Therefore, catheter tube pressure detection is becoming an important application in minimally invasive interventional surgery.

Zhejiang Tsinghua Institute of Flexible Electronic Technology discloses a flexible pressure sensor in 202011049050.0, which includes a catheter, a sensitive element, and an extensible wire. Both the sensitive element and the extensible wire are arranged on the surface of the catheter, and are snake-shaped set, and the extensible wire is electrically connected to the sensitive element. Multiple sensitive elements and extensible wires are prepared at different positions on the surface of the catheter to realize array integration of pressure sensing, thereby realizing multi-point measurement, and multiple sensitive elements can form an array module. When the catheter goes deep into the inside of the blood vessel, the catheter will adapt to the shape of the inside of the blood vessel and undergo bending, stretching or compression deformation. The wire will not form a pulling force on the sensitive element, and the arrayed sensitive element can be firmly adhered to the surface of the catheter without detachment, so that the arrayed flexible pressure sensor has high ductility. However, the catheter mentioned in this flexible pressure sensor is similar to the carrier of the sensitive element, while the non-interventional catheter mentioned in the previous paragraph has a small structure, but the catheter structure mentioned in the patent is easy to bend, Tensile or compressive deformation is not suitable for the application scenario of our interventional catheters.

The invention patent with the application number 201611080407.5 discloses a radiofrequency ablation catheter capable of measuring pressure. This invention is used to assist in positioning. The specific assembly method and the form of the pressure sensor are also not disclosed.

To sum up, there is an urgent need for a new medical interventional catheter with pressure measurement function in the interventional catheter, and the pressure sensor and the medical catheter can meet the functions of compact structure and small space after being assembled.

Contents of the invention

The first object of the present invention is to provide a catheter with pressure measurement function to solve the technical problem in the prior art that the assembled pressure sensor and medical catheter cannot meet the requirements of compact structure and small space.

The second object of the present invention is to provide an intracavity treatment catheter with pressure measurement function to solve the technical problem in the prior art that the assembled pressure sensor and medical catheter cannot meet the requirements of compact structure and small space.

The third purpose of the present invention is to provide an intelligent intracavity treatment device with pressure measurement function, so as to solve the technical problem in the prior art that the assembled pressure sensor and medical catheter cannot meet the requirements of compact structure and small space.

In order to solve the above technical problems, the present invention mainly adopts the following technical means:

The invention provides a catheter with pressure measurement function,

The catheter body is equipped with at least one pressure sensor, the pressure sensor includes a pressure sensing unit and a signal processing unit, the pressure sensing unit includes at least a sensitive element and at least two sensor tail wires,

The sensitive element is arranged on the outer surface of the catheter body and forms a columnar space,

The sensor tail wires are thin strips, which are arranged on the outer surface of the catheter body or protrude into the catheter lumen, and extend along the direction of the catheter body. The sensor tail wires are respectively connected to the catheter body. The sensitive element is installed and set, and the installation position is located in the columnar space,

The pressure sensor senses the radial force and/or frictional force exerted by the tissue on the surface of the catheter body, and/or the axial force exerted on the catheter tip, and transmits the pressure information to the catheter through the signal processing unit. the outside of the catheter.

Preferably, the sensitive element is wound or heat-shrunk on the outer surface of the catheter tube body, so as to make the outer surface of the catheter tube body smooth while controlling the size of the pressure sensor.

Preferably, the pressure sensor adopts a thin-film resistance strain pressure sensor, and the sensitive element includes an elastic diaphragm body, the sensor tail wire, and a connection unit installed with the sensor tail wire. , the elastic membrane body adapts to the size of the catheter body and is rolled on the outer surface of the catheter body, and the connecting unit is extended toward the inner direction of the catheter, so that the sensor tail mounted on it The position of the line does not protrude from the columnar space formed by the rolled elastic diaphragm body.

Preferably, the elastic diaphragm body is wound or heat-shrunk to the outer surface of the catheter tube body, or the outer surface of the catheter tube body is provided with a mounting groove along the circumference of the tube body so as to install the tube without protruding from the outer surface. As for the elastic membrane body, the width of the elastic membrane body wound on the outer surface of the catheter tube body is within the range of 1mm-80mm.

Preferably, a hole matching the number of the sensor tail wires is provided at the fitting position of the catheter body, and the connecting unit and the sensor tail wires protrude into the lumen of the catheter through the holes , and the sensor tail wire is arranged in the lumen of the catheter and extends along the direction of the catheter body.

Preferably, the outer surface of the tube of the catheter is provided with several installation grooves along the circumference to install the sensor tail wires.

Preferably, the connection unit is integrally made with the sensor tail wire, the connection unit is a chamfered structure, and the connection unit is welded between the elastic diaphragm body and the On the inner surface that the catheter barrel contacts.

Preferably, the thickness of the thin film resistance strain pressure sensor is in the range of 0.05mm-1mm; the length is in the range of 1mm-80mm, the measuring range is in the range of 1-100N, and the accuracy is in the range of ±0.1N.

An intracavity treatment catheter, the intracavity treatment catheter includes a catheter insertable section that enters the target lumen lesion, the catheter insertable section includes a working section and an intervention section, and the intracavity treatment catheter adopts the above-mentioned In the above-mentioned catheter with pressure measurement function, at least one pressure sensor is arranged on the working section, and when in use, the pressure sensor detects the pressure value of the lumen of the acting object.

Preferably, the pressure sensor is located on the surface of the catheter, and is used to sense the radial extrusion force or friction force from the surface of the catheter to indicate the radial space where the catheter is located.

Preferably, there are multiple pressure sensors, and at least two of the pressure sensors are located at the tip of the catheter or at both tips of the catheter respectively, so as to obtain the axial force from the tip of the catheter, and then prompt the catheter to The forward direction and axial space.

Preferably, the working temperature of the pressure sensor is -10°C-300°C, and the instantaneous high temperature reaches ≥200°C within 3-5s.

Preferably, the pressure sensor meets the performance requirement of maintaining its basic performance without losing its basic performance after repeated heating or cooling within the working temperature range for 100 times.

A device for intelligent intracavity treatment, the device at least includes a perfusion sub-device and an endocavity treatment sub-device,

The perfusion sub-device includes: a perfusion accessory, which includes a drug reservoir, a liquid circuit, and a puncture device connected in sequence; a perfusion main part, which includes a communication-connected perfusion control system and a perfusion driver. The perfusion driver is used to control the flow rate of the preparation in the liquid circuit, and the perfusion control system is connected in communication with the piercer pressure detector;

The intracavity treatment sub-device includes: the intracavity treatment catheter as described above, the pressure sensor is connected to the perfusion control system in communication; the intracavity treatment device is connected to the intracavity treatment catheter Connected and communicated with the pressure sensor, the intracavitary treatment device is used to generate pulse energy, and obtain the radial force and/or friction force currently applied to the surface of the catheter body through the pressure sensor, and/or The axial force applied to the tip of the catheter is adapted to adjust the pressure information subsequently applied to the catheter.

Compared with the prior art, the present invention has the following advantages:

Firstly: the sensitive element is set on the outer surface of the catheter body and forms a columnar space, the installation position of the sensor tail wire is in the columnar space, and the radial distance of the sensor tail line will not exceed the width of the columnar space formed by the sensitive element, the sensitive element When it is the same as or slightly larger than the width of the catheter body, the size of the catheter with the pressure measurement function of the present invention is controllable, and the pressure sensor that meets the size requirements can be adapted according to the size of the catheter, which can meet the requirements of the catheter with the pressure measurement function. Compact structure and small space requirements.

Then, the sensitive element is wound or heat-shrunk to the surface of the tube body, which can make the surface of the tube body smooth while controlling the size.

Then, when the pressure sensor adopts a thin-film resistance strain pressure sensor, the sensitive element includes an elastic diaphragm body, and the sensor tail wire also includes a connection unit installed with the sensor tail wire. The size of the catheter tube body is rolled on the outer surface of the tube body, and the elastic diaphragm body adapts to the setting of the catheter body size, which can be designed according to the requirements of the tube body with strong practicability, and the elastic diaphragm body Cover the catheter tube directly or through the biological medium, and then let the sensor tail wire be located in the cavity through the opened hole or let the sensor tail wire be located on the catheter surface through the groove opened on the surface of the tube body. The process is simple and easy to assemble, which is very practical .

The catheter barrel is then fitted with pressure sensors that can sense radial force or friction exerted by tissue on the catheter surface, or axial force on the catheter tip. There is a signal processing unit inside the catheter (for example, the signal processing unit includes a signal transmission line), which can transmit the sensed pressure signal to the supporting host and display it, and the operator adjusts the contact force according to the preset value. This kind of catheter can not only detect the pressure value of the current lumen of the target, but also adjust the contact force according to the preset value. The whole treatment can form a real-time treatment circle, and the contact force can be adjusted in real time according to the specific situation. In particular, in minimally invasive interventional surgery, during the advancement of the interventional catheter and the treatment process, the force exerted by the tissue on the catheter is mainly judged by the doctor's feeling. This process has great uncertainty and will vary with different surgeons. It is very large, and requires a lot of practice and experience accumulation, and the learning curve is long. Through the application of this function, the relevant surgical process can be standardized, thereby reducing the difficulty of use by doctors and shortening the learning time. In other words, after the neuron algorithm is applied in this application scenario, the subsequent pressure value of the current lumen of the target can be detected, and the specific position of a certain device applied to the target can be given directly based on deep learning. Adjust the size to make the treatment equipment more intelligent.

Description of drawings

Fig. 1 is a kind of example structural diagram of existing pressure sensor;

Fig. 2 is a structural diagram of an embodiment of a catheter with a pressure measuring function;

Fig. 3A-Fig. 3B are the expansion diagram and usage example diagram of the pressure sensor of the present invention;

Fig. 4A-Fig. 4D are the sectional view and partial enlarged view of the catheter;

Fig. 5 is an example diagram of the intelligent intracavity treatment device;

Fig. 6 is a principle application diagram of a catheter with pressure measurement function.

Detailed ways

Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.

first embodiment

When the applicant needs to develop a catheter with a pressure measurement function, a common idea is to integrate a pressure sensor into the catheter so that the catheter has a pressure measurement function. For example, a pressure sensor includes a pressure sensing unit and a signal processing unit, and the pressure sensing unit includes at least a sensitive element and a conversion element. The signal processing unit includes a signal modulation module and an information communication module. A common conversion element is a Wheatstone bridge. The sensitive element is deformed under pressure, causing the resistance value of the Wheatstone bridge to change, and the Wheatstone bridge becomes unbalanced to generate an electrical signal output. The thin-film resistance strain pressure sensor has received more and more attention due to its excellent performance. It usually uses an elastic diaphragm as a sensitive element, directly sputters a layer of metal film on the elastic diaphragm, and then makes it into a resistor, which is used as the switching element. As shown in FIG. 1 , a thin film resistive strain pressure sensor includes an elastic diaphragm 1112 , a plane straight tail wire 1113 and at least two pins 1114 . The flat straight tails 1113 and pins 1114 are generally used as conversion elements. When the thin film resistance strain pressure sensor is applied to the catheter, it is found that the plane straight tail wire 1113 is usually directly arranged on the end of the elastic diaphragm 1112 by welding, and the welding point has a deviation of several millimeters during welding, thus As a result, there is a large deviation in the size of the width of the entire sensor, and it is impossible to accurately determine the size of the sensor, such as the width. In addition, when the pressure sensor is assembled with the medical catheter, the product size is too large and the surface steps are obvious. However, a large number of medical catheters have compact structures and small spaces. The above-mentioned pressure sensor structure and assembly process cannot meet the pressure detection function of medical interventional catheters. The inventor of this application discovered this technical problem after many tests during project development.

For this reason, the applicant has improved the pressure sensor on this basis, and developed a new type of catheter with pressure measurement function accordingly. The catheter here mainly refers to a medical catheter, also known as a medical catheter, which is mainly used for medical tubular rubber devices, and is divided into two types: external use and internal use. The catheter of the present invention mainly refers to a medical catheter for internal use, also known as It is an interventional medical catheter.

Please refer to FIG. 2 , which is an illustration diagram of an example of a catheter with pressure measuring function according to the present invention. The tube body of the conduit 116 is equipped with at least one pressure sensor 53 . It includes a pressure sensing unit and a signal processing unit (not shown in the figure).

Please also refer to FIGS. 3A-3B , which are diagrams of an example of the pressure sensor 53 of the present invention.

The pressure sensor 53 adopts a thin film resistance strain pressure sensor 53. The pressure sensing unit includes at least a sensitive element and at least two sensor tail wires 113. The sensitive element includes an elastic diaphragm body 112, and the elastic diaphragm body 112 is film-shaped. In this case, the elastic membrane body 112 can be rolled into a shape with a predetermined size. In this example, the elastic membrane body 112 is rolled into a cylindrical space matching the width of the outer surface of the conduit 116 . The sensor tail wire 113 also includes a connection unit 115 installed with the sensor tail wire 113 . The connecting unit 115 may be a chamfered structure, and the connecting unit 115 is welded on the inner surface of the elastic diaphragm body 112 and in contact with the tube body of the conduit 116 . The size of the cylindrical space formed by the elastic diaphragm body 112 of this design is the width dimension value of the sensor. When the connecting unit 115 and the elastic diaphragm body 112 are connected by welding, the welding accuracy and the deviation of the welding points will not be affected. Affects the width range of the sensor. Moreover, the thickness of the elastic diaphragm body 112 is the overall thickness of the sensor, and this design meets the requirements of a compact structure and a small space for a catheter with a pressure measurement function. It should also be noted that the pressure sensor 53 may be a thin film resistance strain pressure sensor 53 or other pressure sensors, and the present invention is not limited to the pressure sensor.

Please refer to Fig. 4A-Fig. 4D, the tube body adaptation position of catheter 116 offers the hole that matches with sensor tail wire 113 numbers, and connecting unit 115 and sensor tail wire 113 protrude into catheter lumen through hole, and The sensor tail wire 113 is arranged in the lumen of the catheter and extends along the tube body of the catheter 116 . When the connection unit 115 is a chamfered structure, the height and angle of the chamfered structure can directly control the position of the sensor tail wire 113 in the catheter lumen. In this example, there are two sensor tail wires 113, and the height and angle of the chamfered structure are set Directly adjust the distance between the two sensor tail wires 113, the distance between the catheter lumen and the lumen surface of the catheter 116 (such as being close to the lumen surface of the catheter 116 or directly in the middle of the catheter 116 cavity, etc. ).

In the state of use, the elastic diaphragm body 112 is adapted to the size of the tube body of the tube 116 and rolled on the outer surface of the tube body, and the connecting unit 115 is extended to the inside of the tube 116, so that the position of the sensor tail wire 113 installed on it is not convex. Out of the columnar space of the rolled elastic film body 112 .

In this example, the connecting unit 115 may be a chamfered structure, or other connecting member structures, but is not limited thereto. In general, the connection unit 115 can be integrally made with the sensor tail wire 113 .

The elastic diaphragm body 112 can be wound or heat-shrunk onto the surface of the pipe body, or the surface of the pipe body is provided with a mounting groove along the circumference of the pipe body to install the elastic diaphragm body 112 so as not to protrude from the surface as much as possible, and roll it outside the pipe body The size and width of the elastic diaphragm body 112 on the surface may be in the range of 1mm-80mm.

The thickness of the thin-film resistance strain pressure sensor 53 is in the range of 0.05mm-1mm; the length is in the range of 1mm-80mm, the measuring range is in the range of 1-100N, and the accuracy is in the range of ±0.1N.

In this example, the sensor tail wires 113 can be arranged in the cavity of the catheter 116, or can be arranged on the outer surface of the catheter 116 cavity, for example, the surface of the pipe body is provided with several installation grooves along the circumference of the outer surface of the tube to install the sensor tail wires 113. The sensor tail wire 113 can also be provided at the tip of the catheter 116 or directly extend out of the catheter 116, all of which should fall within the protection scope of the present invention.

Embodiment two

The pressure sensor 53 can be piezoresistive, or an optical fiber pressure sensor 53 or other sensors can be selected. The catheter with pressure measuring function of the present invention is not limited to a specific type of sensor, as long as it conforms to the core idea of our company, it should fall into the protection scope of the present invention.

A catheter with a pressure measurement function. The catheter 116 is equipped with at least one pressure sensor 53. The pressure sensor 53 includes a pressure sensing unit and a signal processing unit. The pressure sensing unit includes at least a sensitive element and at least two sensor tail wires 113,

The sensitive element is arranged on the outer surface of the tube body of the catheter 116 and forms a columnar space,

The sensor tail wires 113 are thin strips, which are arranged on the outer surface of the catheter 116 body or protrude into the catheter lumen, and extend along the direction of the catheter 116 body. The sensor tail wires 113 are respectively installed with sensitive elements, and the installation positions should be located within the columnar space of the sensitive element,

The pressure sensor 53 senses the radial force and/or friction force exerted by the tissue on the surface of the catheter 116, and/or the axial force applied to the tip of the catheter 116, and transmits the pressure information to the outside of the catheter 116 through the signal processing unit .

The sensitive element is wound or heat-shrunk onto the surface of the pipe body, so as to control the size of the pressure sensor 53 and at the same time make the surface of the pipe body smooth.

The sensitive element of the pressure sensor 53 can be in the form of a block. In this case, the outer surface of the conduit 116 has a groove suitable for the thickness of the block shape. Setting the sensitive element in the groove can also realize embedded installation.

In this example, the number of pressure sensors 53 may be multiple, and each sensor may have two sensor tail wires 113 . The sensor tail wire 113 is in the shape of a thin strip, which is arranged on the outer surface of the catheter 116 or protrudes into the catheter lumen, and extends along the direction of the catheter 116 body. The pressure sensors 53 provided can sense the pressure of the tissue on the catheter 116 respectively. The radial force and/or frictional force exerted on the surface of the tube body, and/or the axial force applied to the tip of the catheter 116 , and the pressure information is transmitted to the outside of the catheter 116 through the signal processing unit. For example, the pressure values sent back by the pressure sensors 53 at the two ends of the conduit 116, the comparison of the pressure value at the end of the general forward direction and the pressure value at the other end can determine whether the current conduit 116 is moving. There is a phenomenon of being blocked.

When the catheter is an interventional catheter, especially for catheters inserted into blood vessels, it is very important to have good biocompatibility. Therefore, a layer of biocompatible material can be coated on the outside of the pressure sensor. The material layer can be an existing biocompatible material layer coated on the catheter. For example, a layer of biocompatible material is directly coated on the outside of the sensitive element of the pressure sensor.

Briefly explain the preparation process of the catheter with pressure measurement function, first S1, open a hole at the preset position of the catheter, and then S2, let the inner surface of the sensitive element of the pressure sensor be coated with glue, and then extend the sensor tail wire into the guide through the hole. In the lumen, and extending along the direction of the catheter body; then S3, the sensitive element is coated on the outer surface of the catheter. After S4, if there are other pressure sensors that need to be installed, through steps S1-S3, all the pressure sensors are installed on the catheter, and finally S5, a layer of biocompatible material is coated on the catheter and/or the sensitive element , and the output end of the signal processing unit is connected to the external interface, and the pressure information is transmitted to the outside of the catheter.

Embodiment Three

In many cases, it is necessary to perfuse the surrounding tissues of the human body with liquid medicine during intracavitary treatment to protect the surrounding tissues or make the cavity group close to the treatment device. Among them, a typical application is that in the process of thermal coagulation treatment of varicose veins of lower extremities using a radio frequency host and a catheter (hereinafter referred to as radio frequency treatment system for varicose veins), it is necessary to inject anesthesia and swelling fluid to peripheral tissues of lower extremity veins. On the one hand, under the pressure of the anesthesia and swelling fluid, the diseased blood vessel wall is pressed against the radiofrequency catheter, and the blood in the blood vessel is discharged to ensure the efficient transfer of heat, thereby ensuring the effectiveness of the treatment. At the same time, the anesthesia and swelling fluid can isolate the treatment site from the surrounding normal tissues and protect the normal tissues. Furthermore, the anesthesia swelling solution can also play an anesthesia effect and improve the patient's experience.

At present, the radiofrequency treatment system for varicose veins does not detect the pressure of blood vessels on the radiofrequency catheter, and the drug perfusion control system does not detect the pressure of the puncture device 14 in the body. Even if some intracavity treatment products or medicinal liquid perfusion products have pressure detection or other detection functions, since the two work independently of each other, the two cannot form a linkage. In this way, the rate and dose of drug infusion are mostly determined by the operator's own experience. Then, there may be problems of too fast rate, too much or too little dose, especially for those who are new to related operations. For this purpose, the above-mentioned catheter with pressure measurement function can be introduced into the intelligent intracavity treatment device.

An intelligent intracavity treatment device according to an embodiment of the present invention, the device at least includes a perfusion sub-device and an endocavity treatment sub-device, and the perfusion sub-device includes:

The perfusion accessory 10 includes a drug reservoir 11, a liquid circuit 12 and a piercer 14 that are connected in sequence;

The perfusion main part 20, the perfusion main part 20 includes a perfusion control system 21 and a perfusion driver 22 connected by communication, the perfusion driver can control the flow rate of the preparation in the liquid circuit 12, and the perfusion control system 21 is connected in communication with the puncture device pressure detector 141;

Endoluminal therapy sub-units include:

The intracavitary treatment catheter 32, the intracavitary treatment catheter 32 includes an extracorporeal section 321, an internal body section 322, and an intracavitary treatment section 323 which are sequentially connected. One or more pressure sensors 53 as mentioned in the above embodiment are provided on it, and the pressure sensor 53 mentioned in the above embodiment is connected with the perfusion control system 21 in communication;

The intracavity treatment device 31 is connected with the intracavity treatment catheter 32 and communicated with the pressure sensor 53 as mentioned in the above embodiment, and the intracavity treatment device is used to generate pulse energy.

The inner section 322 of the treatment catheter is inserted into the cavity of the cavity structure and arrives at the expected position. After the perfusion accessory 10 puncturer 14 enters the tissue around the cavity, the perfusion of the medicinal solution is started. During the perfusion process, the puncturer pressure detector 141 or the pressure sensor 53 mentioned in the above-mentioned embodiments sends the measured pressure data to the perfusion control system or the intracavitary treatment equipment for processing, and then dynamically regulates the perfusion rate. When the puncture When the pressure detector 141 or the pressure sensor 53 mentioned in the above-mentioned embodiments reaches the preset threshold, the system stops perfusion and sends out warning signals such as sound, light, color change, flashing, font or symbol size change.

On the one hand, the intracavitary treatment catheter 32 monitors the pressure of the cavity tissue wall on the treatment catheter, and feeds back to the external treatment device as a reference for the perfusion effect. At the same time, the liquid medicine perfusion product monitors the pressure of the puncture device 14 in the body and feeds it back to the perfusion control system to form a closed-loop control. On the other hand, the intracavity treatment sub-device and the liquid medicine perfusion sub-device can also be connected to form a large system, using the pressure data of the intracavity treatment sub-device and the liquid medicine perfusion sub-device to automatically control the perfusion through the algorithm budget The speed and dosage can achieve the purpose of using the least perfusion liquid and ensuring the therapeutic effect. Moreover, the radial force and/or frictional force currently applied to the surface of the catheter 116 tube body, and/or the axial force applied to the tip of the catheter 116 is obtained through the intracavity pressure sensor 53, so as to adapt and adjust the subsequent application to the catheter 116 pressure information.

Embodiment four

The present invention also provides an intracavitary treatment catheter 32. The intracavitary treatment catheter 32 includes a catheter insertable section 60 that enters the target lumen lesion. , at least one pressure sensor 53 is arranged on the working section 61, and when in use, the pressure sensor 53 detects the pressure value of the lumen of the target lumen. Please refer to FIG. 6 , which is a schematic diagram of an application of the intracavitary treatment catheter 32 . The catheter insertable section 60 enters the lesion site 30 in the human lumen. During diagnosis and treatment, the pressure sensor 53 detects the pressure F from the tissue, and the pressure signal is transmitted to the host computer 70 through the internal signal transmission wire and the extracorporeal section 321 .

Also referring to FIG. 2 , the intracavitary treatment catheter 32 may specifically include a catheter insertable section 60 and an extracorporeal section 321 , the distal end of the catheter insertable section 60 is a working section 61 , and the working section 61 may include a functional section 611 and a pressure sensor 53 , The proximal end is the intervening section 62 ; F is the pressure applied to the working section 61 of the catheter 116 .

In one embodiment, the pressure sensor 53 is located on the surface of the conduit 116 and can sense the radial extrusion force or friction force from the surface of the conduit 116 to indicate the radial space where the conduit 116 is located. In another embodiment, the pressure sensor 53 can be located at the tip of the catheter 116 at the same time, and can sense the axial force from the tip of the catheter 116 to prompt the advancing direction and axial space of the catheter 116 .

The working temperature of the pressure sensor 53 is -10°C-300°C, and the instantaneous high temperature reaches ≥ 200°C within 3-5s. The pressure sensor 53 satisfies the performance requirement of repeatedly heating up or cooling down 100 times within the working temperature range without losing its basic performance.

The specific performance parameters of the sensor are as follows:

The whole treatment can form a real-time treatment ring, and the contact force can be adjusted in real time according to the specific situation. In particular, in minimally invasive interventional surgery, during the advancement of the interventional catheter and the treatment process, the force exerted by the tissue on the catheter is mainly judged by the doctor's feeling. This process has great uncertainty and will vary with different surgeons. It is very large, and requires a lot of practice and experience accumulation, and the learning curve is long. Through the application of this function, the relevant surgical process can be standardized, thereby reducing the difficulty of use by doctors and shortening the learning time. In other words, after the neuron algorithm is applied in this application scenario, the subsequent pressure value of the current lumen of the target can be detected, and the specific position of a certain device applied to the target can be given directly based on deep learning. Adjust the size to make the treatment equipment more intelligent.

The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, if these changes fall within the scope of the claims of the present invention and equivalent technologies, they still fall within the protection scope of the present invention.

Claims (14)

1. A catheter with pressure measuring function is characterized in that,

the catheter body is provided with at least one pressure sensor in an assembling way, the pressure sensor comprises a pressure sensing unit and a signal processing unit, the pressure sensing unit at least comprises a sensing element and at least two sensor tail wires,

the sensitive element is arranged on the outer surface of the catheter body and forms a cylindrical space,

the sensor tail lines are in a thin strip shape, are arranged on the outer surface of the catheter body or protrude into the catheter cavity and extend along the direction of the catheter body, the sensor tail lines are respectively arranged with the sensitive elements, and the installation positions are positioned in the columnar space,

the pressure sensor senses the radial force and/or friction force exerted by the tissue on the surface of the catheter shaft and/or the axial force exerted on the catheter tip, and transmits pressure information to the outside of the catheter through the signal processing unit.

2. The pressure sensing catheter according to claim 1, wherein the sensing element is wrapped or heat shrunk onto the outer surface of the catheter shaft to smooth the outer surface of the catheter shaft while controlling the size of the pressure sensor.

3. The catheter with pressure measuring function according to claim 1, wherein the pressure sensor is a thin film resistance strain pressure sensor, the sensing element includes an elastic diaphragm body, the sensor tail wire, and a connecting unit mounted on the sensor tail wire, in a use state, the elastic diaphragm body is adapted to the catheter body and is wound on the outer surface of the catheter body, and the connecting unit extends towards the inside of the catheter tube so that the position of the sensor tail wire mounted on the connecting unit does not protrude out of the cylindrical space formed by the wound elastic diaphragm body.

4. The pressure measuring catheter as claimed in claim 3, wherein the elastic diaphragm body is wound or shrunk on the outer surface of the catheter shaft, or a pressing groove is formed on the outer surface of the catheter shaft along the circumferential direction of the catheter body so that the elastic diaphragm body is installed without protruding out of the outer surface, and the size width of the elastic diaphragm body wound on the outer surface of the catheter shaft is in the range of 1mm to 80 mm.

5. The catheter with pressure measuring function according to claim 3, wherein holes matched with the number of the sensor tails are formed in the catheter body at the matched positions, the connecting unit and the sensor tails protrude into the cavity of the catheter through the holes, and the sensor tails are arranged in the cavity of the catheter and extend along the direction of the catheter body.

6. The pressure measuring catheter according to claim 1 or 3, wherein a plurality of mounting grooves are formed in the outer surface of the catheter body along the circumferential direction for mounting the sensor tails.

7. The catheter with pressure measuring function according to claim 3, wherein the connecting unit is integrally formed with the sensor tail wire, the connecting unit is of a chamfered structure, and the connecting unit is welded to an inner surface of the elastic diaphragm body, which is in contact with the catheter shaft, in a welding manner.

8. A catheter with pressure measurement function according to claim 3, wherein the thickness of the thin film resistance strain pressure sensor is in the range of 0.05mm to 1 mm; the length is in the range of 1mm-80mm, the range is in the range of 1-100N, and the precision is in the range of +/-0.1N.

9. An intraluminal therapeutic catheter comprising a catheter insertable section into a lesion site of a lumen of a subject, said catheter insertable section comprising a working section and an intervention section, said intraluminal therapeutic catheter employing the catheter having a pressure measurement function according to any one of claims 1 to 8, at least one of said pressure sensors being provided on said working section, said pressure sensor detecting a pressure value of the lumen of the subject in use.

10. The intracavity treatment catheter of claim 9 wherein said pressure sensor is located on said catheter surface for sensing a radially compressive or frictional force from said catheter surface to indicate radial spacing of said catheter.

11. The intracavity treatment catheter of claim 9 wherein said pressure sensor is a plurality of at least two of said pressure sensors located at said catheter tip or at both said catheter tips respectively to obtain axial force from said catheter tip to indicate said catheter advancement direction and axial spacing.

12. The intracavity therapeutic catheter of claim 9 wherein said pressure transducer has an operating temperature of-10 ℃ to 300 ℃ and an instantaneous elevated temperature of 200 ℃ or greater within 3 to 5 seconds.

13. The intracavity therapy catheter of claim 9 wherein said pressure sensor meets performance requirements of repeatedly increasing and decreasing temperature within an operating temperature range of 100 times without loss of substantial performance thereof.

14. An intelligent intracavity therapeutic device is characterized in that,

the device at least comprises a perfusion sub-device and an intracavity treatment sub-device,

the perfusion sub-device comprises: the perfusion accessory comprises a medicine storage device, a liquid path and a puncture device which are sequentially communicated; the perfusion main part comprises a perfusion control system and a perfusion driver which are in communication connection, the perfusion driver is used for controlling the flow of the preparation in the liquid path, and the perfusion control system is in communication connection with the puncture outfit pressure detector;

the intraluminal therapeutic sub-device comprises: the endoluminal treatment catheter according to any of claims 9-13, wherein the pressure sensor is communicatively coupled to the perfusion control system; the intracavity treatment device is connected with the intracavity treatment catheter and is in communication connection with the pressure sensor, the intracavity treatment device is used for generating pulse energy, and the radial force and/or the friction force currently applied to the surface of the catheter body and/or the axial force applied to the catheter tip are obtained through the pressure sensor so as to adapt and adjust the pressure information subsequently applied to the catheter.

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