CN115381735A - Hydrogel dressing for skin oxidation resistance and preparation method thereof - Google Patents
Hydrogel dressing for skin oxidation resistance and preparation method thereof Download PDFInfo
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- CN115381735A CN115381735A CN202210970742.1A CN202210970742A CN115381735A CN 115381735 A CN115381735 A CN 115381735A CN 202210970742 A CN202210970742 A CN 202210970742A CN 115381735 A CN115381735 A CN 115381735A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a hydrogel dressing for skin oxidation resistance and a preparation method thereof, wherein the main material of hydrogel is nonionic polyacrylamide, a hydrogel substrate is prepared by using the nonionic polyacrylamide with the molecular weight of 10,000,000-30,000,000, 1% of salicylic acid is contained in every 10 mL hydrogel substrate, and 0.5-1mL superoxide dismutase (SOD) injection, 100-200mg vitamin C, 25-50 mg vitamin E and 0.5-1mL cationic hyaluronic acid are added. The hydrogel dressing has pH of 5-6, and can be used as dressing to be applied on sterilized skin for resisting oxidation and supplying water to skin, and keeping skin breathable.
Description
Technical Field
The invention relates to the technical field of beauty medicine, in particular to a hydrogel dressing for skin oxidation resistance and a preparation method thereof.
Background
Antioxidation refers to the abbreviation of antioxidant free radical, anti-Oxidant. The human body comprises the following components because of continuous contact with the outside: respiration (oxidation reaction), external pollution, radiation irradiation and other factors continuously generate free radicals in the human body. Antioxidant is any substance that is present at low concentrations to effectively inhibit the oxidation of free radicals, either by acting directly on the free radicals or by indirectly consuming substances that readily form free radicals, preventing further reactions from occurring. The human body inevitably generates free radicals and also naturally generates antioxidant substances resisting the free radicals so as to counteract the oxidative attack of the free radicals on human cells. Scientific studies have shown that cancer, aging or other diseases are mostly associated with the production of excess free radicals. The research on the antioxidation can effectively overcome the harm brought by the antioxidation, so the antioxidation is listed as one of the main research and development directions by health-care products and cosmetic enterprises, and is also one of the most important functional requirements of the market.
The skin consists of several layers covering and protecting the cells of keratin and collagen fibrils that make up its structural skeleton, the outermost of these layers, called the stratum corneum, is known to be composed of 250A protein bundles surrounded by 80A thick layers. Anionic surfactants and organic solvents typically penetrate the stratum corneum membrane and disrupt its integrity by defatting (i.e., removing lipids from the stratum corneum). Disruption of the skin surface topography leads to a rough feel and may eventually cause surfactants or solvents to contact the keratin, creating an irritating sensation. When the stratum corneum is destroyed, the exposed skin is easily repeatedly inflamed and can not be effectively healed if the oxidation resistance treatment is not carried out. At the same time, maintaining a proper moisture gradient across the stratum corneum is important to its function. A significant portion of this water comes from the body and is sometimes seen as a plasticizer for the stratum corneum. If the humidity is too low, like in cold climates, not enough water remains on the outer layers of the stratum corneum to properly plasticize the tissue, and the skin begins to peel and becomes itchy. Skin permeability also decreases to some extent when there is insufficient water to pass through the stratum corneum. Therefore, the hydrogel dressing for skin oxidation resistance is prepared by combining the hydrogel dressing, the oxidation resistant material and 1% of skin moisturizing essence.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide a hydrogel dressing for skin oxidation resistance, which can be well coated on the surface of the skin and has certain oxidation resistance.
Yet another object of the present invention is to: provides a preparation method of the hydrogel dressing for skin oxidation resistance.
The purpose of the invention is realized by the following scheme: an antioxidizing hydrogel dressing for skin is prepared from non-ionic polyacrylamide with molecular weight of 10,000,000-30,000,000 as basic matrix, and the hydrogel matrix of 10 mL contains 1% salicylic acid, 0.5-1mL superoxide dismutase (SOD) injection, 100-200mg VC, 25-50 mg VE, and has pH value not higher than 6.
The invention adopts the hydrogel substrate material with high molecular weight, can be well coated on the surface of skin and is not easy to fall off. Meanwhile, superoxide dismutase, vitamin C and vitamin E contained in the dressing can effectively counteract the oxidative attack of free radicals to skin cells of a human body.
Preferably, the pH value is 5-6.
Furthermore, each 10 mL hydrogel base also contains 1% of skin moisturizing essence. The skin moisturizing essence can effectively ensure the moisture gradient of the skin and accelerate the recovery of the wound.
Furthermore, every 10 mL hydrogel substrate also contains 0.5-1mL cationic hyaluronic acid.
Specifically, the invention provides a hydrogel dressing for skin oxidation resistance, wherein the hydrogel dressing uses non-ionic polyacrylamide with the molecular weight of 10,000,000-30,000,000 to prepare a hydrogel substrate, each 10 mL hydrogel substrate contains 1% of salicylic acid, and 0.5-1mL superoxide dismutase (SOD) injection, 100-200mg vitamin C, 25-50 mg vitamin E and 0.5-1mL cationic hyaluronic acid are added.
The invention also provides a preparation method of the hydrogel dressing for skin oxidation resistance, which comprises the following steps:
adding 99 mL water to a suitably sized container and stirring at 300 rpm/min while adding 15g of a non-ionic polyacrylamide having a molecular weight of 10,000,000, 5g of mineral oil, 0.5-1mL of a superoxide dismutase (SOD) injection, 100-200mg of vitamin C, 50 mg vitamin E, 0-1 mL cationic hyaluronic acid to water to obtain a polyacrylamide aqueous phase;
separately placing 5 mL ethanol into another container, adding a cover, adding 1mL salicylic acid into ethanol by adopting a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
the ethanol mixed solution was slowly added to the polyacrylamide aqueous phase to form a gel, and the resulting gel was mixed at a moderate speed until homogeneous.
The invention discloses a hydrogel dressing for skin antioxidation, which is a hydrogel dressing suitable for facial skin antioxidation by reasonably matching a dispensing agent, overcomes the problem of single effect of the traditional product, and can catalyze superoxide dismutase (SOD) in a formula to convert superoxide radical into hydrogen peroxide and molecular oxygen; vitamin C can remove hydroxyl free radical; each molecule of vitamin E can scavenge the oxidative activity of 120 molecules of singlet oxygen. Therefore, the hydrogel dressing has strong oxidation resistance, and the oxidative stress of skin cells can be greatly weakened by utilizing the oxidation resistance of the hydrogel dressing. Meanwhile, the blood vessel function of the microenvironment around the skin is strengthened, the delivery of nutrients, cytokines and other bioactive molecules to the facial skin is enhanced, and the growth of the facial skin is promoted. Meanwhile, the invention improves the effect defect of a single product by diluting and using a multi-component combined formula, directly acts the composite formula of the hydrogel dressing on the corresponding layers of the main components, reduces the functional disorder of the single product, and greatly improves the one-stop beauty requirements of anti-aging and anti-oxidation.
Detailed Description
In order to more clearly and specifically illustrate the technical solution of the present invention, the present invention is further described by the following embodiments. The following examples are intended to illustrate the practice of the present invention and are not intended to limit the scope of the invention.
Example 1
A hydrogel dressing for skin oxidation resistance, comprising: non-ionic polyacrylamide with molecular weight of 10,000,000, superoxide dismutase (SOD), vitamin C, vitamin E and cation hyaluronic acid, and is prepared by the following steps:
adding 99 mL water to a suitably sized vessel, stirring at 300 rpm/min while adding 15g of a non-ionic polyacrylamide having a molecular weight of 10,000,000, 5g of mineral oil, 0.5 mL superoxide dismutase (SOD) injection, 100 mg vitamin C, 25 mg vitamin E, 0.5 mL cationic hyaluronic acid to water to obtain a polyacrylamide aqueous phase;
separately putting 5 mL ethanol into another container, adding a cover, adding 1mL salicylic acid into ethanol by adopting a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
this ethanol mixed solution was slowly added to the polyacrylamide aqueous phase to form a gel, and the resulting gel was mixed at a moderate speed until homogeneous.
Example 2
A hydrogel dressing for skin oxidation resistance, comprising: non-ionic polyacrylamide with molecular weight of 10,000,000, superoxide dismutase (SOD), vitamin C, vitamin E and cation hyaluronic acid, and is prepared by the following steps:
adding 99 mL water to a suitably sized vessel, stirring at 300 rpm/min while adding 15g of a non-ionic polyacrylamide having a molecular weight of 10,000,000, 5g of mineral oil, 0.75 mL superoxide dismutase (SOD) injection, 150 mg vitamin C, 37.5 mg vitamin E, 0.75 mL cationic hyaluronic acid to water to obtain a polyacrylamide aqueous phase;
separately placing 5 mL ethanol into another container, adding a cover, adding 1mL salicylic acid into ethanol by using a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
this ethanol mixed solution was slowly added to the polyacrylamide aqueous phase to form a gel, and the resulting gel was mixed at a medium speed until uniform.
Example 3
A hydrogel dressing for skin oxidation resistance, comprising: non-ionic polyacrylamide with molecular weight of 10,000,000, superoxide dismutase (SOD), vitamin C, vitamin E and cation hyaluronic acid, and is prepared by the following steps:
adding 99 mL water into a container of suitable size, stirring at 300 rpm/min, while adding 15g of non-ionic polyacrylamide with molecular weight of 10,000,000, 5g of mineral oil, 1mL superoxide dismutase (SOD) injection, 200mg vitamin C, 50 mg vitamin E, 1mL cationic hyaluronic acid to water to obtain polyacrylamide aqueous phase;
separately placing 5 mL ethanol into another container, adding a cover, adding 1mL salicylic acid into ethanol by using a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
this ethanol mixed solution was slowly added to the polyacrylamide aqueous phase to form a gel, and the resulting gel was mixed at a moderate speed until homogeneous.
The hydrogel dressing has remarkable effect after being tried out.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (8)
1. A hydrogel dressing for skin oxidation resistance, characterized in that the hydrogel comprises: the non-ionic polyacrylamide with the molecular weight of 10,000,000-30,000,000, superoxide dismutase (SOD), vitamin C and vitamin E, wherein each 10 mL hydrogel substrate comprises 1 percent of salicylic acid, 0.5-1mL superoxide dismutase (SOD) injection, 100-200mg vitamin C and 25-50 mg vitamin E, and the pH value of the hydrogel dressing is not more than 6.
2. The hydrogel dressing for skin oxidation resistance according to claim 1, which is characterized by a pH value of 5 to 6.
3. The hydrogel dressing for skin oxidation resistance according to claim 1, wherein 1% of skin moisturizing essence is further contained in each 10 mL hydrogel substrate.
4. The hydrogel dressing for skin oxidation resistance according to claim 1, wherein the hydrogel base of 10 mL further comprises 0.5-1mL cationic hyaluronic acid.
5. A method for preparing the hydrogel dressing for skin antioxidation according to any one of claims 1 to 4,
adding 99 mL water into a container, stirring at 300 rpm/min, and simultaneously adding 15g of non-ionic polyacrylamide with molecular weight of 10,000,000, 5g of mineral oil, 0.5-1mL of superoxide dismutase (SOD) injection, 100-200mg of vitamin C, 50 mg vitamin E, 0.5-1mL cationic hyaluronic acid into water to obtain a polyacrylamide water phase;
separately placing 5 mL ethanol into another container, adding a cover, adding 1mL salicylic acid into ethanol by using a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
the ethanol mixed solution was slowly added to the polyacrylamide aqueous phase to form a gel, and the resulting gel was mixed at a moderate speed until homogeneous.
6. The method for preparing a hydrogel dressing for skin oxidation resistance according to claim 5, wherein the hydrogel dressing comprises: non-ionic polyacrylamide with molecular weight of 10,000,000, superoxide dismutase (SOD), vitamin C, vitamin E and cation hyaluronic acid, and is prepared by the following steps:
adding 99 mL water to a suitably sized vessel, stirring at 300 rpm/min while adding 15g of a non-ionic polyacrylamide having a molecular weight of 10,000,000, 5g of mineral oil, 0.5 mL superoxide dismutase (SOD) injection, 100 mg vitamin C, 25 mg vitamin E, 0.5 mL cationic hyaluronic acid to water to obtain a polyacrylamide aqueous phase;
separately putting 5 mL ethanol into another container, adding a cover, adding 1mL salicylic acid into ethanol by adopting a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
this ethanol mixed solution was slowly added to the polyacrylamide aqueous phase to form a gel, and the resulting gel was mixed at a moderate speed until homogeneous.
7. The method for preparing the hydrogel dressing for skin oxidation resistance according to claim 5, wherein the hydrogel dressing comprises: non-ionic polyacrylamide with molecular weight of 10,000,000, superoxide dismutase (SOD), vitamin C, vitamin E and cation hyaluronic acid, and is prepared by the following steps:
adding 99 mL water to a suitably sized vessel, stirring at 300 rpm/min while adding 15g of a non-ionic polyacrylamide having a molecular weight of 10,000,000, 5g of mineral oil, 0.75 mL superoxide dismutase (SOD) injection, 150 mg vitamin C, 37.5 mg vitamin E, 0.75 mL cationic hyaluronic acid to water to obtain a polyacrylamide aqueous phase;
separately placing 5 mL ethanol into another container, adding a cover, adding 1mL salicylic acid into ethanol by using a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
this ethanol mixed solution was slowly added to the polyacrylamide aqueous phase to form a gel, and the resulting gel was mixed at a moderate speed until homogeneous.
8. The method for preparing a hydrogel dressing for skin oxidation resistance according to claim 5, wherein the hydrogel dressing comprises: non-ionic polyacrylamide with molecular weight of 10,000,000, superoxide dismutase (SOD), vitamin C, vitamin E and cation hyaluronic acid, and is prepared by the following steps:
adding 99 mL water into a container of suitable size, stirring at 300 rpm/min, while adding 15g of non-ionic polyacrylamide with molecular weight of 10,000,000, 5g of mineral oil, 1mL superoxide dismutase (SOD) injection, 200mg vitamin C, 50 mg vitamin E, 1mL cationic hyaluronic acid to water to obtain polyacrylamide aqueous phase;
separately placing 5 mL ethanol into another container, adding a cover, adding 1mL salicylic acid into ethanol by using a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
this ethanol mixed solution was slowly added to the polyacrylamide aqueous phase to form a gel, and the resulting gel was mixed at a moderate speed until homogeneous.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210970742.1A CN115381735A (en) | 2022-08-13 | 2022-08-13 | Hydrogel dressing for skin oxidation resistance and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210970742.1A CN115381735A (en) | 2022-08-13 | 2022-08-13 | Hydrogel dressing for skin oxidation resistance and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994013333A1 (en) * | 1992-12-08 | 1994-06-23 | University College Cardiff Consultants Limited | Wound dressings |
| CN109529023A (en) * | 2018-11-19 | 2019-03-29 | 西安惠普生物科技有限公司 | A kind of active liquid dressing of high SOD, preparation method and applications |
| CN112169014A (en) * | 2020-09-27 | 2021-01-05 | 浙江丽能生物医药科技有限公司 | Material for promoting rapid repair of skin surface wound by SOD (superoxide dismutase) and preparation method thereof |
| CN114246976A (en) * | 2021-12-09 | 2022-03-29 | 上海纳米技术及应用国家工程研究中心有限公司 | Hydrogel dressing for wound inflammation diminishing and preparation method thereof |
-
2022
- 2022-08-13 CN CN202210970742.1A patent/CN115381735A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994013333A1 (en) * | 1992-12-08 | 1994-06-23 | University College Cardiff Consultants Limited | Wound dressings |
| CN109529023A (en) * | 2018-11-19 | 2019-03-29 | 西安惠普生物科技有限公司 | A kind of active liquid dressing of high SOD, preparation method and applications |
| CN112169014A (en) * | 2020-09-27 | 2021-01-05 | 浙江丽能生物医药科技有限公司 | Material for promoting rapid repair of skin surface wound by SOD (superoxide dismutase) and preparation method thereof |
| CN114246976A (en) * | 2021-12-09 | 2022-03-29 | 上海纳米技术及应用国家工程研究中心有限公司 | Hydrogel dressing for wound inflammation diminishing and preparation method thereof |
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Application publication date: 20221125 |