CN115337969A - Multi-channel controllable microfluidic chip with good airtightness - Google Patents

Abstract

The invention discloses a multi-channel controllable microfluidic chip with good airtightness. The multi-channel controllable microfluidic chip with good airtightness includes a bottom plate, a cover plate, a connecting pipe and a governor. Each liquid flow channel includes a liquid inlet flow channel, a control groove and a liquid outlet flow channel arranged at intervals. The cover plate is fastened on the bottom plate, and the cover plate is provided with a liquid inlet hole, a liquid outlet hole and a liquid outlet hole. The avoidance groove, the liquid inlet hole is connected with the liquid inlet flow channel, the liquid outlet hole is connected with the liquid outlet flow channel, the avoidance groove is set corresponding to the control groove, one end of the connecting pipe is connected with the liquid inlet flow channel, and the other end is connected with the liquid outlet flow channel, And the connecting pipe is arranged through the control groove, and the governor is arranged in the control groove, and abuts against the connecting pipe to adjust the flow rate of the connecting pipe. The microfluidic chip has better airtightness, and can realize single-channel or multi-channel control more conveniently.

Description

Multi-channel controllable microfluidic chip with good airtightness

technical field

The invention relates to the technical field of medical detection equipment, in particular to a multi-channel controllable microfluidic chip with good airtightness.

Background technique

Microfluidic chips are important basic devices in the fields of biomedical detection and chemical microreactors, and play an important role in the technical fields of nucleic acid amplification detection technology, immune response, and cell division. Development in the direction of integration and functionalization. In the field of biomedical testing and other fields, microfluidic chips involve complex processes such as mixing, reaction, and pretreatment of various reagents in different processes. Therefore, the chip structure needs to meet the control of switching and closing of various flow channels. At the same time, this type of microfluidic chip is widely used in biomedical and other fields and is used in a huge amount. Therefore, microfluidic chips with good airtightness, good controllability, cheap processing, and low cost are required.

In the current research on this type of chip, most of them are prepared with a rotary valve structure, which can meet the requirements of multi-channel switching. In actual use, if the rotary valve is fixed too tightly, it will be difficult to rotate and the device will suffer serious wear and tear, and the rotary valve will be loosely fixed, which will easily cause insufficient airtightness.

Contents of the invention

The purpose of the present invention is to provide a multi-channel controllable microfluidic chip with good airtightness. The microfluidic chip has good airtightness and can realize single-channel or multi-channel control more conveniently.

For realizing above-mentioned technical effect, technical scheme of the present invention is as follows:

The invention discloses a multi-channel controllable microfluidic chip with good airtightness. Channel, control groove and liquid outlet flow channel; cover plate, the cover plate is fastened on the bottom plate, and the cover plate is provided with a liquid inlet hole, a liquid outlet hole and an escape groove, and the liquid inlet hole and The liquid inlet flow channel is connected, the liquid outlet hole is connected with the liquid outlet flow channel, and the avoidance groove is set corresponding to the control groove; a connecting pipe, one end of the connecting pipe is connected with the liquid inlet flow path , the other end communicates with the liquid outlet channel, and the connecting pipe is set through the control tank; the governor, the speed governor is arranged in the control tank, and abuts against the connecting pipe To adjust the flow of the connecting pipe.

In some embodiments, the speed governor includes: a support, the support is arranged in the control groove, and a chute arranged obliquely is provided on the side wall of the support; a roller, the roller can Rollingly arranged in the support, and the axle of the roller fits in the chute, and the roller is pressed on the connecting pipe.

In some specific embodiments, the sliding groove is provided on two opposite side walls of the support.

In some embodiments, the cover plate is a circular plate, and the liquid inlet holes and the liquid outlet holes are evenly spaced along the circumference of the cover plate.

In some embodiments, a plurality of the avoidance grooves are arranged at regular intervals.

In some embodiments, the base plate is a resin plate, and the connecting pipe is embedded in the base plate.

In some embodiments, the cover plate is a glass plate.

In some embodiments, the bottom plate is a circular plate, and the liquid outlet channel includes a liquid outlet arranged in alignment with the liquid outlet hole and a liquid outlet channel connected with the connecting pipe.

In some embodiments, the bottom plate is a circular plate, and the liquid inlet flow channel includes a liquid inlet opening aligned with the liquid inlet hole and a liquid inlet channel connected with the connecting pipe.

In some specific embodiments, the liquid inlet channel includes a plurality of successively connected sub-channels, and the extension directions of two adjacent sub-channels are arranged at an included angle.

The beneficial effect of the multi-channel controllable microfluidic chip with good airtightness in this embodiment: Since the bottom plate and the cover plate are sealed and connected, the liquid inlet channel and the liquid outlet channel can be closed, and the liquid can only flow into the inlet through the inlet hole. In the liquid flow channel, it flows to the liquid flow channel through the connecting tube, and finally leaves the microfluidic chip through the liquid outlet hole. And because the governor is added, the flow of the connecting pipe can be controlled only by adjusting the pressure of the governor on the connecting pipe, thereby realizing single-channel or multi-channel control of the microfluidic chip. The microfluidic chip can realize single-channel or multi-channel control without using a rotary valve, which is convenient for adjustment and also ensures the sealing of the entire microfluidic chip.

Additional aspects and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.

Description of drawings

FIG. 1 is a schematic structural view of a multi-channel controllable microfluidic chip with good airtightness according to an embodiment of the present invention;

Fig. 2 is a schematic diagram of an exploded structure of a well-sealed multi-channel controllable microfluidic chip according to an embodiment of the present invention;

Figure 3 is a schematic cross-sectional view of a well-sealed multi-channel controllable microfluidic chip according to an embodiment of the present invention

Fig. 4 is a schematic structural view of a governor of a well-sealed multi-channel controllable microfluidic chip according to an embodiment of the present invention.

Reference signs:

1. Bottom plate; 11. Liquid inlet channel; 111. Liquid inlet; 112. Liquid inlet channel; 12. Liquid outlet channel; 121. Liquid outlet; 122. Liquid outlet channel; 13. Control tank;

2. Cover plate; 21. Liquid inlet hole; 22. Liquid outlet hole; 23. Avoidance groove;

3. Connecting pipe;

4, governor; 41, bearing; 411, chute; 42, roller.

Detailed ways

In order to make the technical problems solved by the present invention, the technical solutions adopted and the technical effects achieved clearer, the technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and through specific implementation methods.

In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Back", "Left", "Right", "Vertical", "Horizontal", "Top", "Bottom", "Inner", "Outer", "Clockwise", "Counterclockwise", "Axial" , "radial", "circumferential" and other indicated orientations or positional relationships are based on the orientations or positional relationships shown in the drawings, which are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying the referred device or Elements must have certain orientations, be constructed and operate in certain orientations, and therefore should not be construed as limitations on the invention.

In addition, the features defined as "first" and "second" may explicitly or implicitly include one or more of these features, which are used to describe the features differently, without order or importance. In the description of the present invention, unless otherwise specified, "plurality" means two or more.

In the description of the present invention, it should be noted that unless otherwise specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection. Connected, or integrally connected; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention in specific situations.

The specific structure of the well-sealed multi-channel controllable microfluidic chip of the embodiment of the present invention will be described below with reference to FIGS. 1-4 .

The invention discloses a multi-channel controllable microfluidic chip with good airtightness, as shown in Figure 1-2, the multi-channel controllable microfluidic chip with good airtightness in this embodiment includes a bottom plate 1 and a cover plate 2. The connecting pipe 3 and the governor 4, the bottom plate 1 is provided with a plurality of liquid flow channels, each liquid flow channel includes a liquid inlet flow channel 11, a control groove 13 and a liquid outlet flow channel 12 arranged at intervals, and a cover plate 2 Fastened on the bottom plate 1, and the cover plate 2 is provided with a liquid inlet hole 21, a liquid outlet hole 22 and an escape groove 23, the liquid inlet hole 21 is connected with the liquid inlet flow channel 11, and the liquid outlet hole 22 is connected with the liquid outlet flow channel 12, the avoidance groove 23 is set corresponding to the control groove 13, one end of the connecting pipe 3 is connected with the liquid inlet flow channel 11, and the other end is connected with the liquid outlet flow channel 12, and the connecting pipe 3 is set through the control groove 13, and the governor 4 It is arranged in the control groove 13 and abuts against the connecting pipe 3 to adjust the flow of the connecting pipe 3 .

It can be understood that, in the actual assembly process, the liquid inlet channel 11 and the liquid outlet channel 12 can be closed after the bottom plate 1 and the cover plate 2 are sealed, and the liquid can only flow into the liquid inlet channel 11 from the liquid inlet hole 21 , and then flow to the liquid outlet channel 12 through the connecting tube 3, and finally leave the microfluidic chip through the liquid outlet hole 22. And because the governor 4 is added, the flow of the connecting pipe 3 can be controlled only by adjusting the pressure of the governor 4 on the connecting pipe 3, thereby realizing single-channel or multi-channel control of the microfluidic chip. The microfluidic chip of this embodiment can realize single-channel or multi-channel control without using a rotary valve, which is convenient for adjustment and ensures the tightness of the entire microfluidic chip.

Preferably, the base plate 1 and the cover plate 2 are bonded by plasma treatment. Thus, the connection stability and connection sealing performance between the base plate 1 and the cover plate 2 can be improved.

In some embodiments, the speed governor 4 includes a support 41 and a roller 42, the support 41 is arranged in the control groove 13, the side wall of the support 41 is provided with a chute 411 arranged obliquely, and the roller 42 is rotatably arranged In the support 41 , and the axle of the roller 42 fits in the chute 411 , the roller 42 is pressed on the connecting pipe 3 . It can be understood that, since the wheel shaft of the roller 42 fits in the chute 411, when the roller 42 is positioned on the higher side of the chute 411, the pressure on the connecting pipe 3 is relatively small, and the flow in the connecting pipe 3 will be reduced at this moment. Larger, when the roller 42 is located at the lower side of the chute 411, the pressure on the connecting pipe 3 is greater, and even the connecting pipe 3 can be blocked. In the actual operation process, it is only necessary to slide the roller 42 along the length direction of the support 41, and the operation mode of the governor 4 is very simple, which is convenient for the user to operate.

Preferably, the surface of the support 41 is treated with plasma cleaning, so that the side wall of the support 41 is in close contact with the side wall of the control groove 13, so as to prevent the speed governor 4 from shaking.

In some specific embodiments, the sliding groove 411 is provided on two opposite side walls of the support 41 . It can be understood that if only one side wall of the support 41 is provided with a sliding groove 411, it will cause the roller 42 to shake easily, so that the speed governor 4 cannot stably control the flow in the connecting pipe 3, and in the In this embodiment, slide grooves 411 are provided on the two opposite side walls of the support 41 to ensure the stability of the roller 42 , thereby ensuring that the governor 4 can stably control the flow in the connecting pipe 3 .

In some embodiments, the cover plate 2 is a circular plate, and the liquid inlet holes 21 and the liquid outlet holes 22 are evenly spaced along the circumferential direction of the cover plate 2 . It can be understood that the cover plate 2 is a circular plate and the liquid inlet holes 21 and the liquid outlet holes 22 are evenly distributed to facilitate the connection of the microfluidic chip of this embodiment to the external structure, thereby facilitating the use. At the same time, the circular cover plate 2 and the uniformly distributed hole structure facilitate processing, thereby simplifying the processing technology of the cover plate 2 and reducing the manufacturing cost of the cover plate 2 . Of course, in other embodiments of the present invention, the shape of the cover plate 2 and the distribution of the liquid inlet holes 21 and the liquid outlet holes 22 can be selected according to actual needs, and are not limited to the foregoing description.

In some embodiments, a plurality of escape grooves 23 are arranged at regular intervals. Thus, it is convenient to process the escape groove 23 on the cover plate 2 , which simplifies the processing technology of the cover plate 2 and reduces the manufacturing cost of the cover plate 2 . Of course, in other embodiments of the present invention, the distribution of the escape grooves 23 can be adjusted according to actual needs.

In some embodiments, the base plate 1 is a resin plate, and the connecting pipe 3 is embedded in the base plate 1 . It can be understood that, according to the foregoing, the speed governor 4 is pressed on the connecting pipe 3, and the connecting pipe 3 is buried in the bottom plate 1 to prevent the connecting pipe 3 from shaking relative to the bottom plate 1, thereby ensuring that the speed governor 4 can be stably Adjust the flow rate of connecting pipe 3.

Preferably, the connecting pipe 3 is poured and embedded in the bottom plate 1, and the connecting pipes 3 pierced in different control grooves 13 are placed according to certain rules. It is a hose made of plastic.

Preferably, multiple connecting pipes 3 are buried in a staggered manner, so as to avoid interference between two connecting pipes 3 , thereby ensuring that each connecting pipe 3 can be individually regulated under the control of the corresponding governor 4 .

In some embodiments, the cover plate 2 is a glass plate. Thus, the control of the connecting pipe 3 by the governor 4 can be clearly observed, which is convenient for the user to control the flow channel.

In some embodiments, the bottom plate 1 is a circular plate, and the liquid outlet channel 12 includes a liquid outlet 121 aligned with the liquid outlet hole 22 and a liquid outlet channel 122 connected with the connecting pipe 3 . It can be understood that the liquid outlet channel 122 can be used as a buffer channel to avoid the phenomenon that the liquid flow rate is too fast and is directly ejected from the liquid outlet hole 22 .

Preferably, the shape of the liquid outlet 121 is the same as that of the liquid outlet 22 . Thereby, it can be ensured that the liquid can flow out smoothly.

In some embodiments, the base plate 1 is a circular plate, and the liquid inlet channel 11 includes a liquid inlet port 111 aligned with the liquid inlet hole 21 and a liquid inlet channel 112 connected with the connecting pipe 3 . It can be understood that the liquid inlet channel 112 can be used as a buffer channel to avoid the phenomenon that the liquid flow rate is too fast and is directly ejected from the liquid inlet hole 21 .

Preferably, the shape of the liquid inlet 111 is the same as that of the liquid inlet 21 . Thereby, the smooth inflow of liquid can be ensured.

In some specific embodiments, the liquid inlet channel 112 includes a plurality of successively connected sub-channels, and the extension directions of two adjacent sub-channels are arranged at an included angle. In this way, it is possible to avoid the phenomenon that multiple liquid inlet channels 112 intersect, thereby ensuring that each liquid inlet channel 112 is independently arranged.

Example:

The specific structure of a well-sealed multi-channel controllable microfluidic chip according to a specific embodiment of the present invention will be described below with reference to FIGS. 1-4 .

The multi-channel controllable microfluidic chip with good airtightness includes a bottom plate 1, a cover plate 2, a connecting pipe 3 and a governor 4. There are six liquid flow channels on the bottom plate 1, and each liquid flow channel includes interval settings. The liquid inlet channel 11 , the control groove 13 and the liquid outlet channel 12 , the liquid outlet channel 12 includes a liquid outlet 121 aligned with the liquid outlet hole 22 and a liquid outlet channel 122 connected with the connecting pipe 3 . The liquid inlet channel 11 includes a liquid inlet port 111 aligned with the liquid inlet hole 21 and a liquid inlet channel 112 connected with the connecting pipe 3 . The liquid inlet channel 112 includes two successively connected sub-channels, and the extension directions of two adjacent sub-channels are arranged at an included angle. The cover plate 2 is fastened on the bottom plate 1, and the cover plate 2 is provided with a liquid inlet hole 21, a liquid outlet hole 22 and an escape groove 23, the liquid inlet hole 21 is connected with the liquid inlet channel 11, and the liquid outlet hole 22 is connected with the liquid outlet The flow passage 12 is connected, and the avoidance groove 23 is set corresponding to the control groove 13. One end of the connecting pipe 3 is connected with the liquid inlet flow passage 11, and the other end is connected with the liquid outlet flow passage 12, and the connecting pipe 3 is set through the control groove 13. Speed governor 4 comprises bearing 41 and roller 42, and bearing 41 is located in the control groove 13, and the two sidewalls of bearing 41 that are oppositely arranged are all provided with the chute 411 that obliquely sets, and roller 42 is rotatably arranged. In the support 41 , and the axle of the roller 42 fits in the chute 411 , the roller 42 is pressed on the connecting pipe 3 .

In the description of this specification, reference to the terms "some embodiments", "other embodiments", etc. means that a specific feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one implementation of the present invention. example or examples. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The above content is only a preferred embodiment of the present invention. For those of ordinary skill in the art, according to the idea of the present invention, there will be changes in the specific implementation and application scope. limits.

Claims (10)

1. The controllable micro-fluidic chip of multichannel that the leakproofness is good, its characterized in that includes:

the liquid level sensor comprises a bottom plate (1), wherein a plurality of liquid flow channels are arranged on the bottom plate (1), and each liquid flow channel comprises a liquid inlet flow channel (11), a control groove (13) and a liquid outlet flow channel (12) which are arranged at intervals;

the cover plate (2) is buckled on the bottom plate (1), a liquid inlet hole (21), a liquid outlet hole (22) and an avoiding groove (23) are formed in the cover plate (2), the liquid inlet hole (21) is communicated with the liquid inlet flow channel (11), the liquid outlet hole (22) is communicated with the liquid outlet flow channel (12), and the avoiding groove (23) is arranged corresponding to the control groove (13);

one end of the connecting pipe (3) is communicated with the liquid inlet flow channel (11), the other end of the connecting pipe (3) is communicated with the liquid outlet flow channel (12), and the connecting pipe (3) penetrates through the control groove (13);

the speed regulator (4) is arranged in the control groove (13), and the speed regulator (4) is abutted against the connecting pipe (3) to regulate the flow of the connecting pipe (3).

2. The well-sealed multi-channel controllable microfluidic chip according to claim 1, wherein the speed regulator (4) comprises:

the support (41), the support (41) is arranged in the control groove (13), and a chute (411) which is obliquely arranged is arranged on the side wall of the support (41);

a roller (42), wherein the roller (42) is arranged in the support (41) in a rolling manner, the axle of the roller (42) is matched in the sliding groove (411), and the roller (42) is pressed on the connecting pipe (3).

3. The well-sealed multi-channel controllable micro-fluidic chip according to claim 2, wherein said sliding grooves (411) are provided on two opposite side walls of said support (41).

4. The well-sealed multi-channel controllable micro-fluidic chip according to any of claims 1 to 3, wherein the cover plate (2) is a circular plate, and the liquid inlet holes (21) and the liquid outlet holes (22) are uniformly distributed at intervals along the circumferential direction of the cover plate (2).

5. The well-sealed multi-channel controllable micro-fluidic chip according to any of claims 1 to 3, wherein the avoidance grooves (23) are arranged at equal intervals.

6. The well-sealed multi-channel controllable micro-fluidic chip according to any of claims 1 to 3, wherein the base plate (1) is a resin plate, and the connecting tube (3) is embedded in the base plate (1).

7. A well-sealed multi-channel controllable micro fluidic chip according to any of claims 1-3, characterized in that the cover plate (2) is a glass plate.

8. The multi-channel controllable micro-fluidic chip with good tightness as recited in any one of claims 1 to 3, wherein the bottom plate (1) is a circular plate, and the liquid outlet channel (12) comprises a liquid outlet (121) aligned with the liquid outlet hole (22) and a liquid outlet channel (122) connected to the connecting tube (3).

9. A well-sealed multi-channel controllable micro-fluidic chip according to any one of claims 1 to 3, wherein the bottom plate (1) is a circular plate, and the liquid inlet channel (11) comprises a liquid inlet (111) aligned with the liquid inlet hole (21) and a liquid inlet channel (112) connected to the connecting tube (3).

10. The multichannel controllable microfluidic chip with good tightness according to claim 9, wherein the liquid inlet channel (112) comprises a plurality of sections of sequentially connected sub-channels, and the extending directions of two adjacent sections of the sub-channels form an included angle.

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