CN115300762A - Manufacturing process of superfine multi-strand memory alloy guide wire - Google Patents

Abstract

The invention discloses a manufacturing process of an ultra-fine multi-strand memory alloy guide wire, comprising the steps of: first, selecting a plurality of titanium-nickel-based memory alloy wires for stiffening treatment; second, selecting a plurality of stiffened titanium-nickel-based memory alloy wires, Arrange in a circular array, and make one end flush with each other; 3. Pulling multiple wires, during the pulling process, make each wire rotate along its own central axis, and at the same time revolve along the central axis of the circular array, so that the multiple wires are twisted in 4. Perform three-stage heat treatment to shape the twisted wire; 5. Cut the shaped twisted wire to obtain the core wire of the guide wire; 6. Weld one end of the core wire of the guide wire to the distal end member of the guide wire, Weld the push rod on the other end. Beneficial effects: the ultra-fine multi-strand memory alloy guide wire produced by the process of the present invention has precise and smooth external dimensions, good tensile force and torque conduction performance, and high flexible bending degree; and meets the needs of stent interventional therapy for coronary CTO. condition.

Description

A manufacturing process of ultra-fine multi-strand memory alloy guide wire

technical field

The invention relates to the field of medical surgery, in particular to a manufacturing process of an ultrafine multi-strand memory alloy guide wire.

Background technique

The guide wire is also a guide wire or guide wire, which is one of the main tools for percutaneous intubation. The guide wire guides and supports the catheter, helps the catheter enter blood vessels and other cavities, and guides the catheter to reach the lesion smoothly.

The material of the existing guide wire is mostly made of single-strand stainless steel wire with a diameter greater than 0.3 mm, and the grade of the stainless steel is 304 stainless steel. Due to the limitations of its material and diameter, it has the disadvantages of poor force and moment transmission and difficult operation. Especially when there is CTO blockage in the coronary artery of the heart, the interventional stent treatment cannot be implemented with the existing guide wire, so that the patient can only be operated on by open chest bypass surgery.

The existing guide wire also has the problems of poor flexibility, poor passability to curved pipelines, easy puncture of blood vessels to cause false lumen, and injury to other human tissues. Especially when the rotation angle is less than 90 degrees, it is basically impossible to turn, and the positive and negative torques are very different, so it is impossible to complete the surgical situation where the guide wire has no length deformation and torsional force change.

Contents of the invention

In order to solve the above problems, the present invention provides a manufacturing process of ultra-fine multi-strand memory alloy guide wire.

The present invention is achieved through the following technical solutions:

A manufacturing process of an ultra-fine multi-strand memory alloy guide wire, comprising the following steps:

1.1 Select a number of titanium-nickel-based memory alloy wires, pull them into a straight line, and keep them in a 300-400°C environment for 5-10 minutes to make them in a tonic state, and then cool them to room temperature for later use;

1.2 Select x pieces of titanium-nickel-based memory alloy wires after annealing treatment, arrange them in a circular array, and make one end of them flush with each other; where x is a positive integer greater than or equal to 4;

1.3 Pull the flush end of x titanium-nickel-based memory alloy wires. The pulling direction is the axial direction of the titanium-nickel-based memory alloy wires. The central axis of the circular array revolves around, so that x titanium-nickel-based memory alloy wires are twisted together to obtain a twisted wire with a hollow structure; wherein, the rotation direction of the rotation and the revolution are the same;

1.4 Perform three-stage heat treatment on the twisted wire to shape it;

1.5 Cut the shaped twisted wire according to the length of 1000mm-3000mm to obtain a core wire of the guide wire, which is the support section of the guide wire;

1.6 Weld one end of the guide wire core wire to the guide wire distal member, and weld the other end to the push rod to obtain an ultra-fine multi-strand memory alloy guide wire.

A manufacturing process of an ultra-fine multi-strand memory alloy guide wire, comprising the following steps:

2.1 Select several titanium-nickel-based memory alloy wires, pull them into a straight line, keep them in a 300-400°C environment for 5-10 minutes, make them in a tonic state, and then cool them to room temperature for later use;

2.2 Select n+m titanium-nickel-based memory alloy wires after annealing treatment, arrange them in a circular array, form a concentric circle structure with n inner rings and m outer rings, and make one end of them flush with each other; where 2×n =m, n is a positive integer greater than or equal to 4;

2.3 Pull the flush end of n+m titanium-nickel-based memory alloy wires. The pulling direction is the axial direction of the titanium-nickel-based memory alloy wires. During the traction process, each titanium-nickel-based memory alloy wire rotates along its own central axis. At the same time, it revolves along the central axis of the circular array, so that n+m titanium-nickel-based memory alloy wires are twisted together to obtain a hollow twisted wire with a double-layer structure; wherein, the rotation direction of the inner ring is the same as that of the revolution, and the outer ring The rotation direction of rotation and revolution is the same, and the rotation direction of inner ring and outer ring is opposite;

2.4 Perform three-stage heat treatment on the twisted wire to shape it;

2.5 Cut the shaped twisted wire according to the length of 1500mm-2500mm to obtain a core wire of the guide wire, which is the support section of the guide wire;

2.6 Weld one end of the guide wire core wire to the guide wire distal member, and weld the other end to the push rod to obtain an ultra-fine multi-strand memory alloy guide wire.

A manufacturing process of an ultra-fine multi-strand memory alloy guide wire, comprising the following steps:

3.1 Select several titanium-nickel-based memory alloy wires, pull them into a straight line, and keep them in a 300-400°C environment for 5-10 minutes to make them in a tonic state, and then cool them to room temperature for later use;

3.2 Select o+p+q titanium-nickel-based memory alloy wires after annealing treatment, and arrange them in a circular array to form a concentric circle structure with o roots in the inner circle, p roots in the middle circle, and q roots in the outer circle, and make one end mutually Flush; where 4×o=2×p=q, o is a positive integer greater than or equal to 4;

3.3 Pull o+p+q pieces of titanium-nickel-based memory alloy wires at the same end, the pulling direction is the axial direction of the titanium-nickel-based memory alloy wires, and make each titanium-nickel-based memory alloy wire along its own central axis during the traction process Rotate and revolve along the central axis of the circular array at the same time, so that o+p+q titanium-nickel-based memory alloy wires are twisted together to obtain a hollow twisted wire with a three-layer structure; among them, the rotation direction of the inner ring's rotation and revolution Same, the middle ring rotates in the same direction as the revolution, the outer ring rotates in the same direction as the outer ring, the inner ring and the middle ring rotate in the opposite direction, and the inner ring and the outer ring rotate in the same direction;

3.4 Perform three-stage heat treatment on the twisted wire to shape it;

3.5 Cut the shaped twisted wire according to the length of 1500mm-2500mm to obtain a core wire of the guide wire, which is the support section of the guide wire;

3.6 Weld one end of the guide wire core wire to the guide wire distal member, and weld the other end to the push rod to obtain an ultra-fine multi-strand memory alloy guide wire.

Preferably, the above-mentioned titanium-nickel-based memory alloy wire has a diameter of 0.01-0.03 mm.

Preferably, the above-mentioned three-stage heat treatment setting is to draw the twisted wire rod through a three-stage heat box heat treatment and then cool to room temperature; the above-mentioned three-stage heat box is a far-infrared ray or laser heating box, and the temperature at the inlet end of the heat box is 167°C, the temperature at the middle section is 199.5°C, and the temperature at the outlet end is 232°C; the time for any point of the twisted wire from entering the three-stage heat box to leaving it is 6-8 minutes.

Preferably, when the titanium-nickel-based memory alloy wire rotates and revolves, the rotation torque is 6.7N·m, the revolution torque is 17.3N·m, and the traction force is 212N.

Preferably, the above-mentioned ultra-fine multi-strand memory alloy guide wire welded with the distal end member of the guide wire and the push rod is provided with a post-processing step, and the post-processing includes the following steps:

a. Soak the ultra-fine multi-strand memory alloy guide wire in a polytetrafluoroethylene solution, so that its surface is uniformly covered with a polytetrafluoroethylene coating;

b. Then place it in an oven and bake it at 160-190°C, then cool it naturally, and the baking time is 12-20 minutes;

b. Repeat the above steps 1-2 times to obtain the coated ultra-fine multi-strand memory alloy guide wire;

d. Clean the coated ultra-fine multi-strand memory alloy guide wire with an ultrasonic cleaner for 1-2 times and then dry it completely;

e. After complete sterilization by irradiation, the aseptic packaging is put into storage.

The beneficial effect of the present invention is that: the ultra-fine multi-strand memory alloy guide wire produced by the process of the present invention is precise and smooth in shape and size, has good tensile force and torque conduction performance, and can ensure that the elastic deformation is approximately equal to zero under the action of the limit working tension and torque; And the flexible bending within the radius of 0.5mm can reach 90-180 degrees; and it meets the required conditions for stent interventional treatment of cardiac coronary artery CTO.

Description of drawings

Figure 1: Schematic diagram of the structure of the ultra-fine multi-strand memory alloy guide wire in Embodiment 1 of the present invention;

Figure 2: Schematic diagram of the structure of the ultra-fine multi-strand memory alloy guide wire in Example 2 of the present invention;

Fig. 3: Schematic diagram of the structure of the ultra-fine multi-strand memory alloy guide wire in Example 3 of the present invention.

Detailed ways

The present invention will be further described below in conjunction with accompanying drawing and specific embodiment:

Embodiment 1: A kind of manufacturing process of ultra-fine multi-strand memory alloy guide wire, comprises the following steps:

1. Select a number of titanium-nickel-based memory alloy wires with a diameter of 0.02mm, pull them into a straight line, and keep them at 350°C for 8 minutes to make them in a tonic state, and then cool them to room temperature for later use;

2. Select 4 titanium-nickel-based memory alloy wires after annealing treatment, arrange them in a circular array, and make one end of them flush with each other;

3. Pull the flush ends of 4 titanium-nickel-based memory alloy wires. The pulling direction is the axial direction of the titanium-nickel-based memory alloy wires. During the traction process, each titanium-nickel-based memory alloy wire rotates along its own central axis, and at the same time Revolving along the central axis of the circular array, 4 titanium-nickel-based memory alloy wires are twisted together to obtain a twisted wire with a hollow structure;

Among them, the rotation direction of rotation and revolution is the same, the rotation torque is 6.7N m, the revolution torque is 17.3N m, and the traction force is 212N; due to the torsional stress generated by the rotation of the titanium-nickel-based memory alloy wire, coupled with the compound motion of the revolution, Multiple titanium-nickel-based memory alloy wires can be twisted together to form a multi-strand single rope;

4. The twisted wire rod is carried out to three-stage heat treatment and finalization; the process of three-stage heat treatment finalization is: after the twisted wire is pulled through the three-stage heat box heat treatment and finalized, then cool to room temperature; the above-mentioned three-stage heat box is far-infrared or Laser heating box, the temperature at the inlet end of the hot box is 167°C, the temperature at the middle section is 199.5°C, and the temperature at the outlet end is 232°C; the time for any point of the twisted wire from entering the three-stage heating box to leaving it is 8 minutes;

5. Cut the shaped twisted wire according to the length of 1500mm to obtain a core wire of the guide wire, which is the support section of the guide wire;

6. Weld one end of the guide wire core wire to the guide wire distal member, and weld the other end to the push rod to obtain an ultra-fine multi-strand memory alloy guide wire;

The distal component includes a guide wire transition section, a guide wire shaping belt, a guide wire tip and a developing coil, and the above distal components are arranged coaxially with the core wire of the guide wire; the transition section is a tapered conical structure with a diameter of The larger end is connected to the core wire of the guide wire, and the other end is connected to the shaping belt; the peripheral surface of the shaping belt is connected to a developing coil made of platinum, and the end is connected to a guide head;

7. Perform post-processing, the steps are as follows: a. Soak the ultra-fine multi-strand memory alloy guide wire in a polytetrafluoroethylene solution for soaking treatment, so that the surface is evenly covered with a polytetrafluoroethylene coating;

b. Then place it in an oven and bake it at 180°C, then cool it naturally, and the baking time is 18 minutes;

c. Repeat the above steps once to obtain the coated ultra-fine multi-strand memory alloy guide wire;

d. Clean the coated ultra-fine multi-strand memory alloy guide wire with an ultrasonic cleaning machine for 2 times and then dry it completely;

e. After complete sterilization by irradiation, the aseptic packaging is put into storage.

Embodiment 2: a kind of manufacturing process of ultra-fine multi-strand memory alloy guide wire, comprises the following steps:

1. Select a number of titanium-nickel-based memory alloy wires with a diameter of 0.02mm, pull them into a straight line, and keep them at 350°C for 8 minutes to make them in a tonic state, and then cool them to room temperature for later use;

2. Select 12 titanium-nickel-based memory alloy wires after annealing treatment, and arrange them in a circular array to form a concentric circle structure with 4 inner rings and 8 outer rings, and make one end of them flush with each other;

3. Pull the flush ends of 12 titanium-nickel-based memory alloy wires. The pulling direction is the axial direction of the titanium-nickel-based memory alloy wires. During the traction process, each titanium-nickel-based memory alloy wire rotates along its own central axis, and at the same time Revolving along the central axis of the circular array, 12 titanium-nickel-based memory alloy wires are twisted together to obtain twisted wires with a hollow structure;

Among them, the rotation direction of the inner ring is the same as that of the revolution, the rotation direction of the outer ring is the same as that of the revolution, and the rotation direction of the inner ring and the revolution of the outer ring is opposite; the rotation torque is 6.7N m, the revolution torque is 17.3N m, the traction force It is 212N; due to the torsional stress generated by the rotation of the titanium-nickel-based memory alloy wire, coupled with the compound motion of the revolution, multiple titanium-nickel-based memory alloy wires can be twisted together to form a multi-strand double-layer single rope;

4. The twisted wire rod is carried out to three-stage heat treatment and finalization; the process of three-stage heat treatment finalization is: after the twisted wire is pulled through the three-stage heat box heat treatment and finalized, then cool to room temperature; the above-mentioned three-stage heat box is far-infrared or Laser heating box, the temperature at the inlet end of the hot box is 167°C, the temperature at the middle section is 199.5°C, and the temperature at the outlet end is 232°C; the time for any point of the twisted wire from entering the three-stage heating box to leaving it is 8 minutes;

5. Cut the shaped twisted wire according to the length of 1500mm to obtain a core wire of the guide wire, which is the support section of the guide wire;

6. Weld one end of the guide wire core wire to the guide wire distal member, and weld the other end to the push rod to obtain an ultra-fine multi-strand memory alloy guide wire;

The distal component includes a guide wire transition section, a guide wire shaping belt, a guide wire tip and a developing coil, and the above distal components are arranged coaxially with the core wire of the guide wire; the transition section is a tapered conical structure with a diameter of The larger end is connected to the core wire of the guide wire, and the other end is connected to the shaping belt; the peripheral surface of the shaping belt is connected to a developing coil made of platinum, and the end is connected to a guide head;

7. Perform post-processing, the steps are as follows: a. Soak the ultra-fine multi-strand memory alloy guide wire in a polytetrafluoroethylene solution for soaking treatment, so that the surface is evenly covered with a polytetrafluoroethylene coating;

b. Then place it in an oven and bake it at 180°C, then cool it naturally, and the baking time is 18 minutes;

c. Repeat the above steps once to obtain the coated ultra-fine multi-strand memory alloy guide wire;

d. Clean the coated ultra-fine multi-strand memory alloy guide wire with an ultrasonic cleaning machine for 2 times and then dry it completely;

e. After complete sterilization by irradiation, the aseptic packaging is put into storage.

Embodiment 3: a kind of manufacturing process of ultra-fine multi-strand memory alloy guide wire, comprises the following steps:

1. Select a number of titanium-nickel-based memory alloy wires with a diameter of 0.02mm, pull them into a straight line, and keep them at 350°C for 8 minutes to make them in a tonic state, and then cool them to room temperature for later use;

2. Select 28 titanium-nickel-based memory alloy wires after annealing treatment, arrange them in a circular array, form a concentric circle structure with 4 inner rings, 8 middle rings, and 16 outer rings, and make one end of them flush with each other;

3. Pull the flush ends of 28 titanium-nickel-based memory alloy wires. The pulling direction is the axial direction of the titanium-nickel-based memory alloy wires. During the traction process, each titanium-nickel-based memory alloy wire rotates along its own central axis, and at the same time Revolving along the central axis of the circular array, 28 titanium-nickel-based memory alloy wires are twisted together to obtain twisted wires with a hollow structure;

Among them, the inner ring rotates in the same direction as the revolution, the middle ring rotates in the same direction as the revolution, the outer ring rotates in the same direction as the revolution, the inner ring and the middle ring rotate in the opposite direction, and the inner ring and the outer ring rotate in the same direction. The direction of rotation is the same; the rotation torque is 6.7N·m, the revolution torque is 17.3N·m, and the traction force is 212N; due to the torsional stress generated by the rotation of the titanium-nickel-based memory alloy wire, coupled with the compound motion of the revolution, multiple titanium-nickel-based memory alloy wires can be made The base memory alloy wires are twisted together to form a multi-strand three-layer single rope;

4. The twisted wire rod is carried out to three-stage heat treatment and finalization; the process of three-stage heat treatment finalization is: after the twisted wire is pulled through the three-stage heat box heat treatment and finalized, then cool to room temperature; the above-mentioned three-stage heat box is far-infrared or Laser heating box, the temperature at the inlet end of the hot box is 167°C, the temperature at the middle section is 199.5°C, and the temperature at the outlet end is 232°C; the time for any point of the twisted wire from entering the three-stage heating box to leaving it is 8 minutes;

5. Cut the shaped twisted wire according to the length of 1500mm to obtain a core wire of the guide wire, which is the support section of the guide wire;

6. Weld one end of the guide wire core wire to the guide wire distal member, and weld the other end to the push rod to obtain an ultra-fine multi-strand memory alloy guide wire;

The distal component includes a guide wire transition section, a guide wire shaping belt, a guide wire tip and a developing coil, and the above distal components are arranged coaxially with the core wire of the guide wire; the transition section is a tapered conical structure with a diameter of The larger end is connected to the core wire of the guide wire, and the other end is connected to the shaping belt; the peripheral surface of the shaping belt is connected to a developing coil made of platinum, and the end is connected to a guide head;

7. Perform post-processing, the steps are as follows: a. Soak the ultra-fine multi-strand memory alloy guide wire in a polytetrafluoroethylene solution for soaking treatment, so that the surface is evenly covered with a polytetrafluoroethylene coating;

b. Then place it in an oven and bake it at 180°C, then cool it naturally, and the baking time is 18 minutes;

c. Repeat the above steps once to obtain the coated ultra-fine multi-strand memory alloy guide wire;

d. Clean the coated ultra-fine multi-strand memory alloy guide wire with an ultrasonic cleaning machine for 2 times and then dry it completely;

e. After complete sterilization by irradiation, the aseptic packaging is put into storage.

Finally, it should be noted that: the above is only a preferred embodiment of the present invention, and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, it still The technical solutions recorded in the foregoing embodiments may be modified, or some of the technical features may be replaced equivalently, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the within the protection scope of the present invention.

Claims (7)

1. A manufacturing process of ultrafine multi-strand memory alloy guide wire, is characterized in that, comprises the following steps: Select a number of titanium-nickel-based memory alloy wires, pull them into a straight line, and keep them in a 300-400°C environment for 5-10 minutes to make them in a tonic state, and then cool them to room temperature for later use; Select x pieces of titanium-nickel-based memory alloy wires after annealing treatment, arrange them in a circular array, and make one end of them flush with each other; where x is a positive integer greater than or equal to 4; Pull the flush end of x titanium-nickel-based memory alloy wires. The pulling direction is the axial direction of the titanium-nickel-based memory alloy wires. The central axis of the array revolves, so that x titanium-nickel-based memory alloy wires are twisted together to obtain a twisted wire with a hollow structure; wherein, the rotation direction of the rotation and the revolution are the same; The twisted wire is subjected to three-stage heat treatment to shape; Cut the shaped twisted wire according to the length of 1000mm-3000mm to obtain a core wire of the guide wire, which is the support section of the guide wire; One end of the core wire material of the guide wire is welded to the distal end member of the guide wire, and the other end is welded to the push rod to obtain an ultra-fine multi-strand memory alloy guide wire. 2. A manufacturing process of an ultra-fine multi-strand memory alloy guide wire, characterized in that, comprising the following steps: Select a number of titanium-nickel-based memory alloy wires, pull them into a straight line, and keep them in a 300-400°C environment for 5-10 minutes to make them in a tonic state, and then cool them to room temperature for later use; Select n+m titanium-nickel-based memory alloy wires after annealing treatment, arrange them in a circular array, form a concentric circle structure with n inner rings and m outer rings, and make one end of them flush with each other; where 2×n= m and n are positive integers greater than or equal to 4; Pull the flush end of n+m titanium-nickel-based memory alloy wires. The pulling direction is the axial direction of the titanium-nickel-based memory alloy wires. During the traction process, each titanium-nickel-based memory alloy wire rotates along its own central axis, and at the same time Revolving along the central axis of the circular array, twisting n+m titanium-nickel-based memory alloy wires together to obtain a hollow and double-layer twisted wire; wherein, the inner ring rotates in the same direction as the revolution, and the outer ring rotates The rotation direction is the same as the revolution, and the rotation direction of the inner ring and the outer ring is opposite; The twisted wire is subjected to three-stage heat treatment to shape; Cut the shaped twisted wire according to the length of 1500mm-2500mm to obtain a core wire of the guide wire, which is the support section of the guide wire; One end of the core wire material of the guide wire is welded to the distal end member of the guide wire, and the other end is welded to the push rod to obtain an ultra-fine multi-strand memory alloy guide wire. 3. A manufacturing process of an ultra-fine multi-strand memory alloy guide wire, characterized in that, comprising the following steps: Select a number of titanium-nickel-based memory alloy wires, pull them into a straight line, and keep them in a 300-400°C environment for 5-10 minutes to make them in a tonic state, and then cool them to room temperature for later use; Select o+p+q titanium-nickel-based memory alloy wires after annealing treatment, and arrange them in a circular array to form a concentric circle structure with o wires in the inner ring, p wires in the middle ring, and q wires in the outer ring, and make one end of them aligned with each other flat; where 4×o=2×p=q, o is a positive integer greater than or equal to 4; Pull o+p+q titanium-nickel-based memory alloy wires at the same end, the pulling direction is the axial direction of the titanium-nickel-based memory alloy wires, and make each titanium-nickel-based memory alloy wire rotate along its own central axis during the traction process , while revolving along the central axis of the circular array, so that o+p+q titanium-nickel-based memory alloy wires are twisted together to obtain a hollow twisted wire with a three-layer structure; wherein, the rotation direction of the inner ring is the same as that of the revolution , the rotation direction of the middle ring is the same as that of the revolution, the rotation direction of the outer ring is the same as that of the revolution, the rotation direction of the inner ring is opposite to that of the middle ring, and the rotation direction of the inner ring is the same as that of the outer ring; The twisted wire is subjected to three-stage heat treatment to shape; Cut the shaped twisted wire according to the length of 1500mm-2500mm to obtain a core wire of the guide wire, which is the support section of the guide wire; One end of the core wire material of the guide wire is welded to the distal end member of the guide wire, and the other end is welded to the push rod to obtain an ultra-fine multi-strand memory alloy guide wire. 4. The manufacturing process of the ultra-fine multi-strand memory alloy guide wire according to any one of claims 1-3, characterized in that: the diameter of the titanium-nickel-based memory alloy wire is 0.01-0.03 mm. 5. The manufacturing process of the ultra-fine multi-strand memory alloy guide wire according to any one of claims 1-3, characterized in that: the three-stage heat treatment is shaped by pulling the twisted wire through a three-stage heat box heat treatment Then, cool to room temperature; The three-stage heating box is a far-infrared or laser heating box. The temperature at the inlet end of the heating box is 167°C, the temperature at the middle section is 199.5°C, and the temperature at the outlet end is 232°C; any point of the twisted wire enters the three-stage heat box The elapsed time to departure was 6-8 minutes. 6. The manufacturing process of the ultra-fine multi-strand memory alloy guide wire according to any one of claims 1-3, characterized in that: when the titanium-nickel-based memory alloy wire rotates and revolves, the rotation torque is 6.7N·m , the revolution torque is 17.3N·m, and the traction force is 212N. 7. The manufacturing process of the ultra-fine multi-strand memory alloy guide wire according to any one of claims 1-3, characterized in that: the ultra-fine multi-strand memory alloy guide wire welded with the distal end member of the guide wire and the push rod is set There are post-processing steps, and post-processing includes the following steps: Soak the ultra-fine multi-strand memory alloy guide wire in the polytetrafluoroethylene solution to make the surface evenly covered with polytetrafluoroethylene coating; Then put it into an oven and bake it under the condition of 160-190°C, then cool it naturally, and the baking time is 12-20 minutes; Repeat the above steps 1-2 times to obtain a coated ultra-fine multi-strand memory alloy guide wire; Clean the coated ultra-fine multi-strand memory alloy guide wire with an ultrasonic cleaner for 1-2 times and then dry it completely; Then they are completely sterilized by irradiation and put into storage in aseptic packaging.

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