CN1152707C - pill for treating diarrhea - Google Patents

Abstract

A pill for treating diarrhea is characterized in that the weight ratio of the raw material medicaments is as follows: 5-15 parts of codonopsis pilosula; 5-15 parts of raw astragalus; 5-15 parts of rhizoma atractylodis; 5-15 parts of bighead atractylodes rhizome; 5-15 parts of poria cocos; 5-15 parts of Chinese yam; 5-10 parts of fructus amomi; 3-10 parts of amomum tsao-ko; 3-7 parts of nutmeg; 3-10 parts of cooked sliced aconite; 3-7 parts of cinnamon; 3-7 of piper longum; 3-10 parts of fructus alpiniae oxyphyllae; 5-15 parts of Chinese polyphaga; 5-15 parts of pangolin scales; 5-15 parts of fried white peony root; 3-7 of Sichuan coptis root; 3-10 parts of raw liquorice; 10-15 parts of pomegranate rind; 10-30 parts of Chinese pulsatilla root; 10-15 parts of divaricate saposhnikovia root; fructus Psoraleae 10-15 parts and herba Portulacae 10-30 parts. Aiming at the particularity and complexity of chronic diarrhea, the invention regulates and regulates the spleen and the kidney, strengthens the functions of the spleen and the kidney, balances qi, blood and yin and yang in the body, ensures normal ascending, descending, dredging and running of gas, leads the vital qi to be stored in the body, leads the pathogenic factors to go away, has comprehensive medication and wide application range.

Description

Treatment diarrheal pill

Technical field

The present invention relates to a kind of is the preparation that raw material is made with the animals and plants Chinese crude drug, specifically a kind of treatment diarrheal pill.

Background technology

Chronic diarrhea is a kind of common disease, comprises that chronic colitis, chronic dysentery, gastrointestinal dysfunction, irritable bowel syndrome and diet raw food, meat or fish are greasy, is affected by the cold, allergy, psychentonia etc. causes gastroenteropathy.Common sympton has diarrhoea, stool urgent, the suffer from diarrhoea loose stool and the watery stool that weighs, or the sticking peptone of folder, inferior or ten several of day line number, and the course of disease reached more than 3 months.

Though patent medicine and Western medicine among some treatment chronic diarrheas are also arranged, because DeGrain, or have only short-term effect and do not have at a specified future date and basic curative effect, taking for a long time increases the Liver and kidney burden, and toxic side effect should not be taken for a long time.

Summary of the invention

The present invention's purpose is to provide a kind of intestinal environment of improvement that has, promote the intestinal mucosa reparative regeneration, resist harmful microbe invasion and attack and intestinal to the absorption of moisture content with improve the function of digestive system, tonifying speen and tonifying kidney, strengthening the body resistance, treating both the principal and secondary aspects of a disease is cured the diarrheal pill.

Solution of the present invention is a performance Chinese medicine chronic diarrhea advantage, theory of Chinese medical science is taken as the leading factor, the clinical experience of collection more than two decades and folk remedy, successive dynasties empirical formula, state of Chinese medicine in Japan etc., the dialectical combination of creationary proposition is executed and is controlled this traditional Chinese medical science new approaches, particularity and complexity at chronic diarrhea, it is dirty to nurse one's health spleen kidney two emphatically, strengthen the spleen renal function, negative and positive of qi and blood in the balanced body, ensure the normal lifting mediation of gas operation, make in healthy energy deposits that heresy has the outlet, medication is comprehensive, wide accommodation.

Material medicine weight proportion of the present invention is:

Radix Codonopsis 5-15 Radix Astragali 5-15 Rhizoma Atractylodis 5-15 Rhizoma Atractylodis Macrocephalae 5-15 Poria 5-15

Rhizoma Dioscoreae 5-15 Fructus Amomi 5-10 Fructus Tsaoko 3-10 Semen Myristicae 3-7 RADIX ACONITILATERALIS PREPARATA 3-10

Cortex Cinnamomi 3-7 Fructus Piperis Longi 3-7 Fructus Alpiniae Oxyphyllae 3-10 Eupolyphaga Seu Steleophaga 5-15 stir-baked SQUAMA MANITIS 5-15

Radix Paeoniae Alba (parched) 5-15 Rhizoma Coptidis 3-7 Radix Glycyrrhizae 3-10 Pericarpium Granati 10-15 Radix Pulsatillae 10-30

Radix Saposhnikoviae 10-15 Fructus Psoraleae 10-15 Herba Portulacae 10-30

The preferred weight ratio range of material medicine of the present invention is:

Radix Codonopsis 10-15 Radix Astragali 10-15 Rhizoma Atractylodis 10-15 Rhizoma Atractylodis Macrocephalae 10-15 Poria 10-15

Rhizoma Dioscoreae 10-15 Fructus Amomi 5-10 Fructus Tsaoko 3-7 Semen Myristicae 3-7 RADIX ACONITILATERALIS PREPARATA 3-7

Cortex Cinnamomi 3-7 Fructus Piperis Longi 3-7 Fructus Alpiniae Oxyphyllae 3-7 Eupolyphaga Seu Steleophaga 10-15 stir-baked SQUAMA MANITIS 10-15

Radix Paeoniae Alba (parched) 10-15 Rhizoma Coptidis 3-7 Radix Glycyrrhizae 3-7 Pericarpium Granati 10-30 Radix Pulsatillae 10-30

Radix Saposhnikoviae 10-15 Fructus Psoraleae 10-15 Herba Portulacae 10-30

The optimum weight proportioning of material medicine of the present invention is:

Radix Codonopsis 10 Radix Astragali 10 Rhizoma Atractylodis 10 Rhizoma Atractylodis Macrocephalaes 10 Poria 10 Rhizoma Dioscoreaes 10

Fructus Amomi 10 Fructus Tsaokos 10 Semen Myristicaes 5 RADIX ACONITILATERALIS PREPARATA 5 Cortex Cinnamomis 5 Fructus Piperis Longi 5

Eupolyphaga Seu Steleophaga 10 stir-baked SQUAMA MANITISs 10 Radix Paeoniae Alba (parched)s 10 Rhizoma Coptidis 5 Radix Glycyrrhizae 5 Pericarpium Granatis 15

The Radix Pulsatillae 15 Radix Saposhnikoviaes 10 Fructus Psoraleaes 15 Herba Portulacaes 15 Fructus Alpiniae Oxyphyllae 5

The above each raw material is made method for producing medicines of the present invention is:

1, said medicine is dried after with flushing with clean water;

Get Radix Codonopsis, Radix Astragali, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Fructus Amomi, Fructus Tsaoko, Semen Myristicae, RADIX ACONITILATERALIS PREPARATA, Cortex Cinnamomi, Fructus Piperis Longi, Fructus Alpiniae Oxyphyllae, Eupolyphaga Seu Steleophaga, stir-baked SQUAMA MANITIS, Radix Paeoniae Alba (parched), Rhizoma Coptidis processing pulverizing, cross 120 order fineness powder;

2, get Radix Glycyrrhizae, Pericarpium Granati, the Radix Pulsatillae, Radix Saposhnikoviae, Fructus Psoraleae, Herba Portulacae and decoct with water 30 minutes, taking liquid is retained;

3, get vinegar and calculate by every kilogram of medicamental pulverata 100ml, with fry in shallow oil among the medicinal liquid body mix;

4, Chinese medicinal powder is made the water pill agent jointly with the liquid that Chinese herbs decoction mixes with vinegar, behind the drying and sterilizing treatment diarrheal pill.

The clinical use result of medicine of the present invention shows that following advantage is arranged:

1, to select the natural animal-plant medical material for use be raw material in the present invention, and each component meets tcm theory, meets the pharmaceutical control law regulation.Utilize combination that medicine is executed and control, be used for the treatment of chronic diarrhea, nontoxic to human body.

2, the chronic diarrhea state of an illness is heavy, and the course of treatment, elder's effect was obvious, was not only short-term effect, and its long-term effect is also good, follows up a case by regular visits to surplus the part patient ten year not show effect.

3, the present invention is through clinical application, can replace other treatment chronic diarrhea medicine, and is cheap, and general patient all can bear (every month expenses for medicine with 100 surplus yuan), and the present invention emphasizes to effect a permanent cure, and reaches the purpose of radical cure.

For showing the therapeutic effect of medicine of the present invention to chronic diarrhea, the present invention selects 260 routine chronic diarrhea patients, all is to adopt other Chinese medicine and western medicine not have obvious curative effects person.

Concrete scheme:

1.1 object

260 examples are the outpatient.Male's 182 examples wherein, women's 78 examples, 46.6 ± 8.2 years old mean age.Inclusion criteria: defecate every day more than 2 times, the course of disease had stomachache, diarrhoea loose stool and Mucous Stool or accompanies symptoms such as sticking peptone, abdominal swelling more than 3 months.Chronic colitis 156 examples wherein, chronic dysentery 12 examples, irritable bowel syndrome 8 examples, gastrointestinal dysfunction 68 examples, other reason 16 examples.Risk factor: diet raw food meat or fish is greasy, is affected by the cold allergy, psychentonia etc.

1.2 take treatment diarrheal pill of the present invention, every day 3 times, each 6g takes after the decoction, 30 days was 1 course of treatment, general 1-3 course of treatment, added 1-2 the course of treatment in case of necessity.

1.3 observational technique

Clinical symptoms: observe situations such as diarrhoea number of times, character, performance, anus, the position of stomachache, character, the cold and hot situation of chance, abdominal distention, borborygmus, inappetence, tenesmus and General Symptoms, tongue fur pulse condition.Necessary physical examination and physico-chemical examination.

To the time is long or the state of an illness is heavier and doubtful case, make fibercolonscopy, get rid of polyp, tumor etc., as changing the place of examination, in order to avoid delay treatment for polyp or tumor.

1.4 sick the effect observed

Whole effective-the symptoms that disappear of produce effects-symptom disappear substantially

Invalid-symptom does not have change

2 results

2.1 after taking treatment diarrheal pill, the diarrhoea number of times obviously reduces, and is reduced to average 1.6 ± 1.1 times of treatment back preceding average 6.0 ± 4.2 times by treatment.260 routine patients have 236 examples (accounting for 90.77%) to begin to take a turn for the better in January.Treat to March, only 24 examples still have times of defecation to increase or other symptom, and the diarrhoea disappearance rate is 96.92%.

2.2 the change of stool character

After taking treatment diarrheal pill, the stool character is clearly better.

Stool character before and after table 1 treatment diarrheal pill is cured

	Rare water just	Mushy stool	The mucus example	Bloody purulent stool	Soft stool	Formed stool
							Before curing	58	157	65	8	26	0
After curing	0	12	2	0	10	236

Rare water just disappearance rate is 100%, and the mushy stool disappearance rate is 92.36%, and the Mucous Stool disappearance rate is 96.92%, and the bloody purulent stool disappearance rate is 100%.

2.3 clinical symptoms is improved situation

The improvement situation of clinical symptoms before and after table 2 treatment diarrheal pill is cured

	Total routine number	Produce effects	Effectively	Invalid	Total effectively (%)
						Stomachache	182	143	34	5	177(97.25)
Abdominal distention	146	132	12	2	144(98.63)
						Inappetence	82	68	13	1	81(98.78)
Abdominal tenderness	69	61	4	4	65(94.20)
						Behind the pain in the abdomen	57	49	7	5	87(94.25)
Passage of gas by anus	92	73	14	5	87(94.57)

2.4 the course of treatment, curative effect was added up

Table 3 treatment diarrheal pill curative effect situation

	Total routine number	Produce effects	Effectively	Invalid	Total effectively (%)
						30 days	260	72	164	24	236(90.70)
60 days		78	74	12	248(95.38)
						90 days		62	16	8	252(96.92)

2.5 result

Table 4 treatment diarrheal pill therapeutic outcome

	Total routine number	Produce effects	Effectively	Invalid	Effectively total
						Case load	260	236	16	8	252
(％)	100	90.77	6.15	3.08	96.92

2.6 other doing well,improving

Chronic diarrhea patient is because of the long-term nutrition incomplete absorption, still becomes thin, other symptom such as tired unable, fatiguability, easy catching a cold.By relaxing recipe after the treatment, nutrition can be absorbed fully widely.Edible Fructus Musae of constipation with dry stool patient or the food that can not take usually adapt to gradually, form benign cycle thereby strengthen gastrointestinal function.

2.7 untoward reaction

260 examples in taking treatment diarrheal pill process, xerostomia 16 examples (6.15%), constipation with dry stool 18 examples (6.92%) do not influence treatment.

If matched group and the treatment of this group are observed, matched group adopts Western medicine and Chinese medicine or Chinese patent drugs for treatment.Need to prove that especially the present invention treats the patient and all accepted western medicines in treatment, proved that the present invention treats chronic diarrhea and is better than other medicines.

Table 5 medicine of the present invention and matched group medicine statistics

	Case load	Produce effects	Effectively	Invalid	Total effectively (%)
						Treatment diarrheal pill	260	236	16	8	252(96.92)
Matched group	62	10	22	30	32(51.61)

The specific embodiment

Embodiment one:

By following proportioning weighting raw materials thing (kilogram)

Radix Codonopsis 10 Radix Astragali 10 Rhizoma Atractylodis 10 Rhizoma Atractylodis Macrocephalaes 10 Poria 10 Rhizoma Dioscoreaes 10

Fructus Amomi 10 Fructus Tsaokos 10 Semen Myristicaes 5 RADIX ACONITILATERALIS PREPARATA 5 Cortex Cinnamomis 5 Fructus Piperis Longi 5

Eupolyphaga Seu Steleophaga 10 stir-baked SQUAMA MANITISs 10 Radix Paeoniae Alba (parched)s 10 Rhizoma Coptidis 5 Radix Glycyrrhizae 5 Pericarpium Granatis 15

The Radix Pulsatillae 15 Radix Saposhnikoviaes 10 Fructus Psoraleaes 15 Herba Portulacaes 15 Fructus Alpiniae Oxyphyllae 7

To dry after the said medicine flushing with clean water, get Radix Codonopsis, Radix Astragali, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Fructus Amomi, Fructus Tsaoko, Semen Myristicae, RADIX ACONITILATERALIS PREPARATA, Cortex Cinnamomi, Fructus Piperis Longi, Fructus Alpiniae Oxyphyllae, Eupolyphaga Seu Steleophaga, stir-baked SQUAMA MANITIS, Radix Paeoniae Alba (parched), Rhizoma Coptidis processing powder and be broken into 120 order fineness powder; Get Radix Glycyrrhizae, Pericarpium Granati, the Radix Pulsatillae, Radix Saposhnikoviae, Fructus Psoraleae, Herba Portulacae and decoct with water 30 minutes, taking liquid adds 14 liters of mixing of vinegar, Chinese medicinal powder is made the water pill agent jointly with the liquid of Chinese medicine decocting liquid and vinegar mixing, and drying and sterilizing is promptly obtained treatment diarrheal pill.

Embodiment two: by following proportioning weighting raw materials thing (kilogram)

Radix Codonopsis 5 Radix Astragali 5 Rhizoma Atractylodis 5 Rhizoma Atractylodis Macrocephalaes 5 Poria 5 Rhizoma Dioscoreaes 5

Fructus Amomi 5 Fructus Tsaokos 3 Semen Myristicaes 3 RADIX ACONITILATERALIS PREPARATA 3 Cortex Cinnamomis 3 Fructus Piperis Longi 3

Eupolyphaga Seu Steleophaga 5 stir-baked SQUAMA MANITISs 5 Radix Paeoniae Alba (parched)s 5 Rhizoma Coptidis 3 Radix Glycyrrhizae 3 Pericarpium Granatis 10

The Radix Pulsatillae 10 Radix Saposhnikoviaes 10 Fructus Psoraleaes 10 Herba Portulacaes 10 Fructus Alpiniae Oxyphyllae 3

To dry after the said medicine flushing with clean water, get Radix Codonopsis, Radix Astragali, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Fructus Amomi, Fructus Tsaoko, Semen Myristicae, RADIX ACONITILATERALIS PREPARATA, Cortex Cinnamomi, Fructus Piperis Longi, Fructus Alpiniae Oxyphyllae, Eupolyphaga Seu Steleophaga, stir-baked SQUAMA MANITIS, Radix Paeoniae Alba (parched), Rhizoma Coptidis processing powder and be broken into 120 order fineness powder; Get Radix Glycyrrhizae, Pericarpium Granati, the Radix Pulsatillae, Radix Saposhnikoviae, Fructus Psoraleae, Herba Portulacae and decoct with water 30 minutes, taking liquid adds 7 liters of mixing of vinegar, Chinese medicinal powder is made the water pill agent jointly with the liquid of Chinese medicine decocting liquid and vinegar mixing, and drying and sterilizing is promptly obtained treatment diarrheal pill.

Embodiment three: take by weighing raw material (kilogram) by following proportioning

Radix Codonopsis 15 Radix Astragali 15 Rhizoma Atractylodis 15 Rhizoma Atractylodis Macrocephalaes 15 Poria 15 Rhizoma Dioscoreaes 15

Fructus Amomi 10 Fructus Tsaokos 7 Semen Myristicaes 7 RADIX ACONITILATERALIS PREPARATA 7 Cortex Cinnamomis 7 Fructus Piperis Longi 7

Eupolyphaga Seu Steleophaga 15 stir-baked SQUAMA MANITISs 15 Radix Paeoniae Alba (parched)s 15 Rhizoma Coptidis 7 Radix Glycyrrhizae 10 Pericarpium Granatis 30

The Radix Pulsatillae 30 Radix Saposhnikoviaes 15 Fructus Psoraleaes 15 Herba Portulacaes 30 Fructus Alpiniae Oxyphyllae 10

To dry after the said medicine flushing with clean water, get Radix Codonopsis, Radix Astragali, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Fructus Amomi, Fructus Tsaoko, Semen Myristicae, RADIX ACONITILATERALIS PREPARATA, Cortex Cinnamomi, Fructus Piperis Longi, Fructus Alpiniae Oxyphyllae, Eupolyphaga Seu Steleophaga, stir-baked SQUAMA MANITIS, Radix Paeoniae Alba (parched), Rhizoma Coptidis processing powder and be broken into 120 order fineness powder; Get Radix Glycyrrhizae, Pericarpium Granati, the Radix Pulsatillae, Radix Saposhnikoviae, Fructus Psoraleae, Herba Portulacae and decoct with water 30 minutes, taking liquid adds 20 liters of mixing of vinegar, Chinese medicinal powder is made the water pill agent jointly with the liquid of Chinese medicine decocting liquid and vinegar mixing, and drying and sterilizing is promptly obtained treatment diarrheal pill.

Claims (3)

1, a kind of treatment diarrheal pill is characterized in that its material medicine weight proportion is:

Radix Codonopsis 5-15 Radix Astragali 5-15 Rhizoma Atractylodis 5-15 Rhizoma Atractylodis Macrocephalae 5-15 Poria 5-15

Rhizoma Dioscoreae 5-15 Fructus Amomi 5-10 Fructus Tsaoko 3-10 Semen Myristicae 3-7 RADIX ACONITILATERALIS PREPARATA 3-10

Cortex Cinnamomi 3-7 Fructus Piperis Longi 3-7 Fructus Alpiniae Oxyphyllae 3-10 Eupolyphaga Seu Steleophaga 5-15 stir-baked SQUAMA MANITIS 5-15

Radix Paeoniae Alba (parched) 5-15 Rhizoma Coptidis 3-7 Radix Glycyrrhizae 3-10 Pericarpium Granati 10-15 Radix Pulsatillae 10-30

Radix Saposhnikoviae 10-15 Fructus Psoraleae 10-15 Herba Portulacae 10-30

The above each raw material is made method for producing medicines of the present invention is:

1), said medicine is dried after with flushing with clean water;

Get Radix Codonopsis, Radix Astragali, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Fructus Amomi, Fructus Tsaoko, Semen Myristicae, RADIX ACONITILATERALIS PREPARATA, Cortex Cinnamomi, Fructus Piperis Longi, Fructus Alpiniae Oxyphyllae, Eupolyphaga Seu Steleophaga, stir-baked SQUAMA MANITIS, Radix Paeoniae Alba (parched), Rhizoma Coptidis processing pulverizing, cross 120 order fineness powder;

2), get Radix Glycyrrhizae, Pericarpium Granati, the Radix Pulsatillae, Radix Saposhnikoviae, Fructus Psoraleae, Herba Portulacae and decoct with water 30 minutes, taking liquid is retained;

3), get vinegar and calculate by every kilogram of medicamental pulverata 100ml, with fry in shallow oil among the medicinal liquid body mix;

4), Chinese medicinal powder is made the water pill agent jointly with the liquid that Chinese herbs decoction mixes with vinegar, behind the drying and sterilizing treatment diarrheal pill.

2,, it is characterized in that the weight proportion of its material medicine is according to the described medicine of claim 1:

Radix Codonopsis 10-15 Radix Astragali 10-15 Rhizoma Atractylodis 10-15 Rhizoma Atractylodis Macrocephalae 10-15 Poria 10-15

Rhizoma Dioscoreae 10-15 Fructus Amomi 5-10 Fructus Tsaoko 3-7 Semen Myristicae 3-7 RADIX ACONITILATERALIS PREPARATA 3-7

Cortex Cinnamomi 3-7 Fructus Piperis Longi 3-7 Fructus Alpiniae Oxyphyllae 3-7 Eupolyphaga Seu Steleophaga 10-15 stir-baked SQUAMA MANITIS 10-15

Radix Paeoniae Alba (parched) 10-15 Rhizoma Coptidis 3-7 Radix Glycyrrhizae 3-7 Pericarpium Granati 10-30 Radix Pulsatillae 10-30

Radix Saposhnikoviae 10-15 Fructus Psoraleae 10-15 Herba Portulacae 10-30.

3,, it is characterized in that the weight proportion of its material medicine is according to the described medicine of claim 1:

Radix Codonopsis 10 Radix Astragali 10 Rhizoma Atractylodis 10 Rhizoma Atractylodis Macrocephalaes 10 Poria 10 Rhizoma Dioscoreaes 10

Fructus Amomi 10 Fructus Tsaokos 10 Semen Myristicaes 5 RADIX ACONITILATERALIS PREPARATA 5 Cortex Cinnamomis 5 Fructus Piperis Longi 5

Eupolyphaga Seu Steleophaga 10 stir-baked SQUAMA MANITISs 10 Radix Paeoniae Alba (parched)s 10 Rhizoma Coptidis 5 Radix Glycyrrhizae 5 Pericarpium Granatis 15

The Radix Pulsatillae 15 Radix Saposhnikoviaes 10 Fructus Psoraleaes 15 Herba Portulacaes 15 Fructus Alpiniae Oxyphyllae 5.