CN115245554A - A kind of Poria medicinal composition with the effect of invigorating the stomach and eliminating the spleen and application thereof - Google Patents

Abstract

The invention relates to a Poria medicinal composition with the functions of strengthening the stomach and eliminating the spleen, comprising the following raw materials in parts by weight: 4-8 parts of Poria cocos, 2-5 parts of yam, 2-5 parts of white lentils, 2-4 parts of Coix seed, 1-3 parts of jujube, 1-3 parts of Gorgon, 1-3 parts of Amomum, 1-3 parts of dried ginger, 1-4 parts of red bean, 1-5 parts of orange peel, 1-3 parts of hawthorn, 1-2 parts of malt 1 to 4 parts of Agaricus, 1 to 3 parts of Xiangshu, 1 to 3 parts of Houttuynia cordata, 1 to 3 parts of dandelion, 1 to 3 parts of mint, 1 to 3 parts of purslane, 1 to 3 parts of chicory, purple 1 to 3 parts of Su Ye and 1 to 3 parts of Gardenia. The composition of the present invention regulates the human body to a certain extent from various angles of the heart, liver, lung, spleen and kidney, and has remarkable effects on strengthening the spleen and removing dampness, strengthening the stomach and eliminating food.

Description

A kind of Poria medicinal composition with the effect of strengthening the stomach and eliminating the spleen and its application

technical field

The invention relates to the field of biomedicine, in particular to a Poria cocos medicinal composition with the functions of invigorating the stomach and eliminating the spleen and its application, its preparation method and its application.

Background technique

The main function of the stomach is two points: one is to digest food, the food ingested by the human body needs to enter the stomach through the esophagus, then be digested by the stomach, and then transferred to the small intestine; the other is to transport nutrients, the stomach digests the food and extracts it Nutrients in food are transmitted to all parts of the body through the blood. If the stomach can complete the work of absorbing nutrients, it can not only deliver nutrients to other organs in the body on time, but also increase appetite and invigorate the spirit. If the digestive function of the stomach decreases, it will not only affect appetite, but also cause bad breath. Weak spleen and stomach and indigestion are mostly manifested as upper abdominal discomfort or pain, fullness, heartburn, nausea and other phenomena, often due to chest tightness, Satiety, bloating and other discomforts and unwilling to eat or eat a small amount of food, most of the existing digestive aids cure the symptoms but not the root cause, can not play a good role in regulating the human body, and have different degrees of toxic and side effects, long-term use can easily lead to the body The imbalance of the microenvironment affects the health of the body.

Poria is a fungus belonging to the Poria family. It has the functions of diuretic and dampness, invigorating the spleen, calming the heart and soothing the nerves. It is widely used to prevent and treat edema, oliguria, phlegm and dizziness, spleen deficiency and lack of food, loose stools and diarrhea, restlessness, and palpitation. Insomnia embolism. The carboxymethyl tuckahoe polysaccharide extracted from Poria cocos has excellent pharmacological effects: 1) It depends on the immune system of the host, enhances the immunity of the body (specific and non-specific), and inhibits and kills tumor cells. By activating complement, a variety of lymphocyte activity factors are induced, and the activity of macrophages, NK cells, T lymphocytes and B lymphocytes is enhanced, and the multi-channel synergistic synergy plays an anti-tumor and anti-viral effect; 2) Inhibits tumor cell DNA , RNA synthesis, directly kill and kill tumor cells; 3) Increase the content of sialic acid (SA) on the tumor cell membrane, inhibit the conversion of PI, reduce the content of arachidonic acid (C ₂₀ ), and inhibit the division and proliferation of tumor cells in multiple ways ;

4) Enhance liver SOD activity, scavenge oxygen free radicals, dissolve carcinogens, and prevent DNA mutation in normal cells.

Chinese yam is a good product for invigorating the lungs, invigorating the spleen and invigorating the kidneys. Yam contains amylase, polyphenol oxidase and other substances, which are beneficial to the digestion and absorption function of the spleen and stomach. Regardless of spleen yang deficiency or stomach yin deficiency, it can be eaten. Clinically, it is commonly used to treat spleen and stomach weakness, lack of appetite, fatigue, diarrhea and other symptoms. Yam contains a variety of nutrients, which can strengthen the body and nourish the kidney and essence. It can be used for any symptoms such as kidney deficiency and nocturnal emission, women with more leucorrhea and frequent urination. Chinese yam contains saponins and mucus, which have lubricating and moisturizing effects, so it can benefit lung qi, nourish lung yin, and treat lung deficiency and phlegm and chronic cough.

The main functions of white lentils are to invigorate the spleen, relieve dampness, and stop diarrhea. White lentils can strengthen the spleen and stomach, clear summer dampness, and are very effective for patients with weak spleen and stomach, diarrhea due to summer heat, and leucorrhea.

Raw barley is cold and cool, and it is the most effective in diverting water and dampness. It can remove dampness and wind, clear heat and expel pus, remove arthralgia and relieve pain.

Chixiaodou is used as medicine, which has the effect of invigorating blood, invigorating spleen and removing dampness, diuresis and swelling. It has a long history of application in diuresis, drench, dehumidification and yellowing, and there are many prescriptions, such as Chixiaodou soup in "Shengji Zonglu", Mahuang Lianqiao Chixiaodou soup in "Treatise on Febrile Diseases", and Chixiaodou powder in "Shenghui Fang". Modern research has found that it has a good effect in the treatment of acute nephritis, liver cirrhosis, ascites, chickenpox, mumps, inflammatory external hemorrhoids, skin diseases and other diseases, and also has various effects such as antioxidant and estrogen-like.

SUMMARY OF THE INVENTION

The object of the present invention is to provide a Poria medicinal composition with the effect of invigorating the stomach and eliminating the spleen, comprising the following raw materials by weight: 4-8 parts of Poria cocos, 2-5 parts of Chinese yam, 2-5 parts of white lentils, 2-5 parts of Coix seed 4 servings, 1-3 servings of jujube, 1-3 servings of Gorgon, 1-3 servings of Amomum, 1-3 servings of dried ginger, 1-4 servings of red bean, 1-5 servings of orange peel, 1-3 servings of hawthorn, malt 1-2 parts, 1-4 parts of Agaricus, 1-3 parts of Xiangshu, 1-3 parts of Houttuynia cordata, 1-3 parts of dandelion, 1-3 parts of mint, 1-3 parts of purslane, 1-3 parts of chicory 1 to 3 servings of perilla leaves, and 1 to 3 servings of gardenia.

In the preferred technical solution of the present invention, the content of Poria in the composition is 1-2.5 parts, preferably 1.5-2 parts.

In a preferred technical solution of the present invention, the Poria cocos in the composition is any one of the Poria cocos coarse powder, the alkalized extract of the polysaccharide of the polysaccharide, the polysaccharide of the polysaccharide, and the polysaccharide of the high degree of substitution carboxymethyl polysaccharide (CMP).

In the preferred technical solution of the present invention, the preparation method of the high-substitution carboxymethyl tuckahoe polysaccharide includes the following steps: 1) The tuckahoe polysaccharide is added to the water or water-alcohol mixed solution, and after stirring evenly, the tuckahoe polysaccharide quality 1-8 is added % alkaline solution, stirred until completely dissolved, to obtain Poria cocos polysaccharide alkaline solution; 2) after 1.0-10mol/L chloroacetic acid and an appropriate excess of 2.0-10mol/L alkaline solution are fully reacted, add to 1) step obtained In the alkaline solution of Poria cocos polysaccharide, carry out a substitution reaction, separate and purify, and then obtain, the appropriate excess means that the actual amount of the alkaline substance in the alkaline solution is 0.5- to 40%.

In the preferred technical solution of the present invention, the tuckahoe polysaccharide described in step 1 is selected from the tuckahoe polysaccharide alkalized extract prepared by the alkalization extraction method or the crude tuckahoe polysaccharide prepared by the alkali extraction acid precipitation method.

In a preferred technical solution of the present invention, the preparation method of the alkalized extract of Poria cocos polysaccharide comprises the following steps: adding an alkaline solution with a concentration of 1.0-4.0mol/L to the Poria cocos powder for alkalization extraction, centrifugation, and taking the supernatant liquid, that is.

In the preferred technical solution of the present invention, the preparation method of the Poria polysaccharide comprises the following steps: the Poria powder is extracted by stirring with an alkaline solution with a concentration of 1.0-4.0 mol/L, centrifuged, and the supernatant is taken; the supernatant is added with acid, the obtained acid precipitate is centrifuged and washed with water to obtain Poria cocos polysaccharide, wherein the acid is selected from any one of acetic acid, hydrochloric acid, sulfuric acid and nitric acid.

In a preferred technical solution of the present invention, the concentration of the alkaline solution is 2.0-3.0 mol/L.

In the preferred technical scheme of the present invention, the water-alcohol mixed solution is a solution prepared by adding water to an alcohol solvent, and the alcohol solvent is selected from methanol, ethanol, propylene glycol, ethyl acetate, acetone, dimethyl sulfoxide, diethyl ether, isotope Any one or a combination of propanol, dimethylformamide.

In the preferred technical solution of the present invention, the alkaline solution added in step 1) is 2-6% of the mass of Poria cocos polysaccharide, and preferably the alkaline solution added in step 1) is 3-5% of the mass of Poria cocos polysaccharide.

In a preferred technical solution of the present invention, the alkaline solution is prepared by dissolving an alkaline substance in water, and the alkaline substance is selected from any one of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate or a combination thereof.

In a preferred technical solution of the present invention, the alkaline substance is selected from any one of sodium hydroxide or potassium hydroxide or a combination thereof.

In the preferred technical solution of the present invention, the concentration of the chloroacetic acid solution is 2.0-9.0 mol/L, preferably 3.0-8.0 mol/L, more preferably 4.0-7.0 mol/L, still preferably 4.5-6.0 mol/L L.

In the preferred technical solution of the present invention, the concentration of the alkaline solution in step 2) is 3.0-9.0 mol/L, preferably 4.0-8.0 mol/L, more preferably 5.0-7.0 mol/L, and preferably 5.5- 6.5mol/L.

In the preferred technical solution of the present invention, the appropriate excess means that the actual amount of the alkaline substance in the alkaline solution is 5-30% more than the theoretical amount required for the neutralization reaction with chloroacetic acid, preferably 10-25%, More preferably it is 15-20%.

In the preferred technical solution of the present invention, the reaction solution in step 2) is subjected to substitution reaction at 30-100° C. for 1-5 hours.

In the preferred technical solution of the present invention, the reaction time in step 2) is 2-4h, preferably 2.5-3.5h.

In the preferred technical solution of the present invention, the reaction temperature in step 2) is 40-90°C, preferably 50-85°C, more preferably 60-82°C, and still preferably 75-80°C.

In the preferred technical solution of the present invention, the separation includes the following steps: adding 1.0-10 mol/L acid solution to the reaction product in step 2), adjusting its pH to 5.0-7.0, adding 3-5 times the volume of an alcohol solvent, and the CMP crude product is precipitated, and the alcohol solvent is selected from any one or a combination of methanol, ethanol, propylene glycol, ethyl acetate, isopropanol, diethyl ether, and acetone.

In a preferred technical solution of the present invention, the acidic solution is prepared by dissolving an acidic substance in water, and the acidic substance is selected from any one of acetic acid, hydrochloric acid, sulfuric acid or nitric acid or a combination thereof.

In the preferred technical solution of the present invention, the purification includes the following steps: adding water to the CMP to be purified to prepare a 1.0-6.0% aqueous solution, adding 1.0-10 mol/L alkaline solution to adjust the pH to 9.0-12.0, and stirring until CMP is completely dissolved; add 30% H ₂ O ₂ solution, the amount of which is 0.1‰-2.0‰ of the total volume of the solution, to carry out decolorization reaction; add 1.0-10mol/L acid solution to adjust pH to 5.0-7.0, remove molecular weight by ultrafiltration CMP and other small molecule impurities less than 0.7×10 ⁴ Daltons.

In a preferred technical solution of the present invention, the concentration of the CMP aqueous solution to be purified is 2.0-5.0%, preferably 3-4%.

In the preferred technical solution of the present invention, the concentration of the alkaline solution used in the purification step is 2.0-9.0 mol/L, preferably 3.0-8.0 mol/L, more preferably 4.0-7.0 mol/L, still preferably 5.0-6.0 mol/L /L.

In the preferred technical solution of the present invention, the dosage of the 30% H ₂ O ₂ solution is 0.5‰-1.0‰ of the total volume of the solution.

In a preferred technical solution of the present invention, the decolorization reaction temperature is 10°C-70°C, preferably 15°C-60°C, more preferably 20°C-50°C.

In the preferred technical solution of the present invention, the time of the decolorization reaction is 2-48h, preferably 5-40h, more preferably 10-30h, still preferably 15-25h.

In a preferred technical solution of the present invention, the concentration of the acidic solution is 1.0-9.0 mol/L, preferably 2.0-8.0 mol/L, more preferably 3.0-7.0 mol/L, preferably 4.0-6.0 mol/L.

In the preferred technical solution of the present invention, the ultrafiltration medium is a DH-UF hollow fiber ultrafilter.

In a preferred technical solution of the present invention, the separation and purification are multiple times of separation and purification.

In the preferred technical solution of the present invention, the substitution degree of CMP is not less than 1.05, preferably not less than 1.10, more preferably not less than 1.2.

In a preferred technical solution of the present invention, the molecular weight of the CMP is 0.7×10 ⁴ -1.0×10 ⁶ Daltons, preferably 3.0×10 ⁴ -8×10 ⁵ Daltons, more preferably 6.0×10 ⁴ - 5.0×10 ⁵ Daltons, preferably 8.0×10 ⁴ to 3.0×10 ⁵ Daltons.

In a preferred technical solution of the present invention, the degree of polymerization of the CMP is 32<n<4545, preferably 136<n<3636, more preferably 272<n<2272, and still preferably 363<n<1363.

In a preferred technical solution of the present invention, the composition also contains a required amount of a pharmaceutically acceptable carrier.

In a preferred technical solution of the present invention, the pharmaceutically acceptable carrier is selected from fillers (also known as diluents), lubricants (also known as glidants or anti-adhesives), dispersants, wetting agents, and adhesives , any one or a combination of regulators, solubilizers (also known as stabilizers), antioxidants, emulsifiers, flavoring agents, and flavoring agents.

In the preferred technical scheme of the present invention, the binder is selected from syrup, gum arabic, gelatin, sorbitol, tragacanth, cellulose, microcrystalline cellulose, sodium carboxymethyl cellulose, ethyl cellulose, hydroxy Any of propyl methylcellulose, gelatin slurry, syrup, starch, sodium carboxymethyl starch, sodium starch glycolate, pregelatinized starch, modified starch, hydroxypropyl starch, corn starch, starch slurry, polyvinylpyrrolidone or a combination thereof.

In the preferred technical scheme of the present invention, the filler is selected from lactose, powdered sugar, dextrin, starch or its derivatives, cellulose, microcrystalline cellulose, sodium carboxymethyl cellulose, ethyl cellulose, hydroxy Propylmethylcellulose, calcium sulfate, calcium phosphate, calcium hydrogen phosphate, precipitated calcium carbonate, sorbitol, glycine, sodium carboxymethyl starch, sodium starch glycolate, pregelatinized starch, modified starch, hydroxypropyl starch, corn Any one or a combination of starches.

In a preferred technical solution of the present invention, the lubricant is selected from any one or a combination of micropowder silica gel, magnesium stearate, talc, aluminum hydroxide, boric acid, hydrogenated vegetable oil, and polyethylene glycol.

In the preferred technical scheme of the present invention, the disintegrating agent is selected from starch, sodium carboxymethyl starch, sodium starch glycolate, pregelatinized starch, modified starch, hydroxypropyl starch, corn starch, polyvinylpyrrolidone, Any one of bipolyvinylpyrrolidone, microcrystalline cellulose, or a combination thereof.

In the preferred technical scheme of the present invention, the wetting agent is selected from any one of sodium lauryl sulfate, water, and alcohol or a combination thereof.

In a preferred technical scheme of the present invention, the emulsifier is selected from any one of polysorbate-80, sorbitan bisulfate, pluronic F-68, lecithin, soybean lecithin, or a combination thereof.

In the preferred technical scheme of the present invention, the acid-base regulator is selected from any one of inorganic acids and organic acids or a combination thereof, preferably selected from citric acid, sodium citrate, malic acid, sodium malic acid, hydrochloric acid, acetic acid , Sodium acetate, phosphoric acid, sodium hydrogen phosphate, sodium dihydrogen phosphate, carbonic acid, sodium carbonate, sulfonic acid, sodium sulfonate, glutamic acid, tartaric acid, sodium tartrate, lactic acid, sodium lactate, fumaric acid, sodium fumarate, coating Aconic acid, ascorbic acid, sodium ascorbate, niacin, sodium nicotinate, fumaric acid, alpha-ketoglutaric acid, fruit acid, sodium fruit acid, acetic acid, oxalic acid, succinic acid, carbon dioxide, citric acid, sodium citrate one or a combination thereof.

In the preferred technical solution of the present invention, the concentration of the acid-base regulator is 0.5-8 mol/L, preferably 0.8-6 mol/L, more preferably 1-5 mol/L, and still preferably 2-4 mol/L.

In a preferred technical solution of the present invention, the stabilizer (solubilizer) is selected from any one of glycerol, Tween-80 or a combination thereof.

In the preferred technical scheme of the present invention, the antioxidant is selected from any one of potassium sorbate, sodium sulfite, sodium bisulfite, sodium metabisulfite, and dibutyl benzoic acid or a combination thereof.

In a preferred technical solution of the present invention, the flavoring agent is selected from any one of spice, edible flavor, and edible essence or a combination thereof.

The compositions of the present invention can be in various dosage forms well known in the art, and can be prepared by conventional formulation techniques in the art.

In a preferred technical solution of the present invention, the composition is an oral preparation.

In the preferred technical scheme of the present invention, the oral preparation is selected from oral liquid (liquid preparation), syrup, suspension, tablet, capsule, granule, pill, powder, dropping pill, mixture, dew, Any of effervescent, paste, emulsion, and tea.

In the preferred technical solution of the present invention, the active ingredient can also be mixed with a pharmaceutically acceptable sustained and controlled release carrier according to its preparation requirements, and then according to the preparation method of sustained and controlled release preparations well known in the art, such as adding a blocking agent bag Coating or microencapsulating the active ingredients and then making slow-release pellets or controlled-release pellets; the slow-release and controlled-release carriers include but are not limited to oleaginous admixtures, hydrocolloids or coating blockers, etc., Described oleaginous admixture is selected from any one or its combination of glycerol monostearate, hydrogenated castor oil, mineral oil, polysiloxane, dimethylsiloxane; Any one or a combination of sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, PVP, acacia, tragacanth, and carbopol; the coating retards The agent is selected from any one of ethyl cellulose (EC), hydroxypropyl methyl cellulose (HMPC), polyvinyl pyrrolidone (PVP), cellulose acetate phthalate (CAP), acrylic resin, or a combination thereof.

In the preferred technical solution of the present invention, the composition comprises the following raw materials by weight: 4 parts of Poria, 2 parts of Chinese yam, 2 parts of white lentils, 2 parts of Coix seed, 1 part of jujube, 1 part of Gorgon Fructus, 1 part of Amomum glutinosa, 1 part of dried ginger, 2 parts of red bean, 2 parts of orange peel, 1 part of hawthorn, 1 part of malt, 2 parts of Agaricus, 1 part of coriander, 1 part of Houttuynia cordata, 1 part of dandelion, 1 part of mint, 1 part of purslane , 1 part of chicory, 1 part of perilla leaves, 1 part of gardenia.

Another object of the present invention is to provide a preparation method of a Poria cocos medicinal composition with the effect of strengthening the stomach and invigorating the spleen. The composition comprises the following raw materials in parts by weight: 4-8 parts of Poria cocos, 2-5 parts of yam, 2-5 parts of white lentils 5 servings, 2-4 servings of coix seed, 1-3 servings of jujube, 1-3 servings of Gorgon, 1-3 servings of Amomum, 1-3 servings of dried ginger, 1-4 servings of red bean, 1-5 servings of orange peel, 1-3 parts of hawthorn, 1-2 parts of malt, 1-4 parts of Agaricus, 1-3 parts of Xiangshu, 1-3 parts of Houttuynia cordata, 1-3 parts of dandelion, 1-3 parts of mint, 1-3 parts of purslane 3 parts, 1 to 3 parts of chicory, 1 to 3 parts of perilla leaves, and 1 to 3 parts of gardenia, the specific preparation method includes the following steps: mix all raw materials evenly, pulverize to 60-140 mesh, and sterilize.

Another object of the present invention is to provide the application of the Poria cocos medicinal composition provided by the present invention with the effect of invigorating the stomach and eliminating the spleen for preparing a product for improving gastrointestinal function.

In a preferred technical solution of the present invention, the improving gastrointestinal function is selected from any one of enhancing immunity, anti-virus, protecting liver, antibacterial, diuretic, anti-fatigue, preventing and treating constipation, gastrointestinal inflammation and indigestion.

In the preferred technical scheme of the present invention, the dosage of the composition is related to factors such as the patient's age, gender, health status, treatment status, and concomitant medication, and the recommended dosage is 5-10 g/time, 2-3 times/day.

Unless otherwise specified, when the present invention relates to the percentage between liquid and liquid, the percentage is volume/volume percentage; when the present invention relates to the percentage between liquid and solid, the percentage is volume/weight percentage; the present invention When referring to percentages between solids and liquids, the percentages are weight/volume percentages; the remainder are weight/weight percentages.

Compared with the prior art, the present invention has the following beneficial technical effects:

(1) The composition of the present invention is scientifically screened for the composition and proportioning of the raw materials, with Poria as the main ingredient, and Poria has a certain effect in invigorating the spleen and removing dampness, but when used alone or only with several raw materials in combination, its effect It is not ideal, and the operating mechanism of the human body is complicated. The present invention continuously adjusts the test formula and finds that several main ingredients such as yam, white lentils, coix seed, and red bean are added, and Amomum glutinosa, dried ginger, orange peel, hawthorn, malt, After the accessories such as Agaricus, Fragrance, Houttuynia cordata, dandelion, mint, purslane, chicory, perilla leaves, and gardenia, the ingredients of the ingredients are compounded to produce a synergistic effect. The spleen and kidneys adjust the human body to a certain extent from all angles, and have significant effects on strengthening the spleen and eliminating dampness, strengthening the stomach and digesting food.

Poria, sweet in taste, mild in nature, calm in nature, returns to the heart, lung, spleen, and kidney meridians, diuresis and dampness, invigorates the spleen, calms the heart; Chinese yam, sweet in nature, warm, calm, non-toxic, invigorates deficiency, removes cold and heat pathogenic qi, nourishes Zhong, invigorating energy, invigorating the spleen and nourishing the stomach, invigorating body fluid and benefiting the lung, invigorating the kidney and astringent essence; white lentils, invigorating the spleen and removing dampness, and relieving heat stroke; Coix seed, invigorating the spleen and draining dampness, eliminating arthralgia and stopping diarrhea, clearing heat and expelling pus; jujube, Invigorating the middle and benefiting qi, nourishing the blood and soothing the nerves; Gorgon fruit, invigorating the kidney and solidifying the essence, invigorating the spleen and stopping diarrhea, removing dampness and stopping the belt; Amomum glutinosa, acrid in taste, warm in nature, returning to the spleen, stomach, and kidney meridians, fragrant and expelling, lowering the middle Rising, dispelling dampness and appetizing, warming the spleen and stopping diarrhea; dry ginger, warming the middle and dispelling cold, Huiyang and Tongmai, drying dampness and eliminating phlegm; Chixiaodou, reducing water and swelling, detoxifying and expelling pus; Phlegm; hawthorn, digestion and stomach, promoting qi and dissipating blood stasis; malt, promoting qi and digestion, invigorating spleen and appetizing, reducing milk and distension; Huoxiang, pungent, slightly warm, returning to spleen, stomach, lung meridian, aromatic and dampness, and stomach-stopping Vomiting, dispelling filth and neutralizing, dispelling summer heat and relieving table, have good bactericidal and antiseptic effect; Xiangzhu, sweating to relieve table, neutralize dampness; , antiviral, improve immunity, diuretic and other effects; dandelion, enter the liver and stomach meridians, clear heat and detoxify, reduce swelling and dissipate knots, detoxify food, disperse stagnant qi; peppermint, dispelling wind-heat, clearing the head, clearing the rash, Peppermint contains menthol, which has antiseptic and sterilizing, diuretic, phlegm-reducing, stomach-strengthening and digestive-aiding effects; purslane, clearing heat and detoxifying, cooling blood and stopping bleeding; chicory, clearing liver and gallbladder, strengthening spleen and digestion, diuresis and swelling; perilla Leaf, dispelling external cold, promoting qi and stomach; gardenia, purging fire and eliminating vexation, clearing heat and diuretic, cooling blood and detoxifying.

(2) The pharmaceutical composition of the present invention has rich raw materials, is easy to produce, has a clear mouthfeel, and has a fresh fragrance. After taking it for a period of time, it can play the effects of strengthening the spleen and calming the heart, reducing food and stomach, promoting qi and dissipating blood stasis, and has a beneficial effect on the human body. It has a good health care effect, and has significant economic and social benefits.

(3) The pharmaceutical composition of the present invention is fully considered not only in terms of efficacy, but also in terms of smell, taste and safety, and its raw material components and formulations have been obtained through long-term tests and verifications.

(3) All the raw materials described in the present invention are of the same origin as medicine and food, and each component and combination have been carefully considered and tested, without any toxic and side effects. The preparation method has the advantages of simple operation, remarkable cost-effectiveness, and is suitable for large-scale industrial production.

Detailed ways

The present invention will be described below with reference to Examples. However, the present invention is not limited to the examples.

Example 1

The Poria cocos composition described in this embodiment includes the following raw materials: 4kg of Poria cocos, 2kg of Chinese yam, 2kg of white lentils, 2kg of Coix seed, 1kg of jujube, 1kg of Gorgon fruit, 1kg of Amomum chinensis, 1kg of dried ginger, 2kg of red bean, 2kg of orange peel, Hawthorn 1kg, Malt 1kg, Agaricus 2kg, Fragrance 1kg, Houttuynia cordata 1kg, Dandelion 1kg, Mint 1kg, Purslane 1kg, Chicory 1kg, Perilla leaf 1kg, Gardenia 1kg, mix all the raw materials and grind to 60 ~140 mesh to get mixed powder, divide the mixed powder into bags and sterilize.

Example 2

The Poria health granules described in this embodiment include the following raw materials: Poria 4kg, Chinese yam 2kg, white lentils 2kg, Coix seed 2kg, jujube 1kg, Gorgon fruit 1kg, Amomum glutinosa 1kg, dried ginger 1kg, red bean 2kg, orange peel 2kg, Hawthorn 1kg, Malt 1kg, Agaricus 2kg, Fragrance 1kg, Houttuynia cordata 1kg, Dandelion 1kg, Mint 1kg, Purslane 1kg, Chicory 1kg, Perilla leaf 1kg, Gardenia 1kg.

Its preparation method comprises the following steps:

1) Soaking: add water that accounts for 8 times the mass of the Poria compound into the Poria compound, and soak the Poria compound for 60min after stirring and soaking;

2) Extraction: Continue to add water that accounts for 8 times the mass of the Poria compound material, start timing after heating to boiling, keep the micro-boiling extraction for 60 min, and filter to obtain the first extract; continue to add water that accounts for 6 times the mass of the Poria compound material to the filter residue , start timing after heating to boiling, keep the micro-boiling extraction for 50 min, and filter to obtain the second extract; continue to add water that accounts for 5 times the mass of the Poria composite material into the filter residue, start timing after heating to boiling, keep the micro-boiling extraction for 40 min, filter The third extraction solution is obtained, the first extraction solution, the second extraction solution and the third extraction solution are combined and passed through a 300-mesh screen to obtain a mixed extraction solution for subsequent use;

3) Concentration and drying: the mixed extract is heated and concentrated until the quality of the mixed extract is 1 times the quality of the Poria cocos composite material to obtain a concentrated solution, the concentrated solution is spray-dried to obtain the Poria cocos composite powder, and the Zhan Poria composite powder is added in the spray drying process. 8 parts by mass of soluble starch or maltodextrin or a mixture of both;

4) Seasoning: Mix the Poria compound powder and seasonings evenly. The seasonings include aspartame, 1.03% sodium cyclamate and 15% xylitol, which account for 1.03% of the weight of the Poria compound powder. When adding, mix the Poria compound powder with Aspartame, sodium cyclamate and xylitol can be mixed evenly, and the seasoning can also be white granulated sugar or sucrose which accounts for 200% of the mass of Poria compound powder;

5) Granulation: Add soluble starch or maltodextrin or a mixture of the two to the seasoned Poria compound powder so that the overall mass is 20 times the mass of the Poria compound powder, and then use 60% to 80% ethanol solution in a wet process. The Poria health-care granules are obtained by granulating in a mixing granulator, and the Poria health-care granules are sterilized and then packaged in bags.

Example 3

The Poria health drink described in this embodiment includes the following raw materials: Poria 4kg, Chinese yam 2kg, white lentils 2kg, Coix seed 2kg, jujube 1kg, Gorgon Fructus 1kg, Amomum chinensis 1kg, dried ginger 1kg, Chixiaodou 2kg, orange peel 2kg, Hawthorn 1kg, Malt 1kg, Agaricus 2kg, Fragrance 1kg, Houttuynia cordata 1kg, Dandelion 1kg, Mint 1kg, Purslane 1kg, Chicory 1kg, Perilla leaf 1kg, Gardenia 1kg.

Its preparation method comprises the following steps:

1) Soaking: add water that accounts for 8 times the mass of the Poria compound into the Poria compound, and soak the Poria compound for 60min after stirring and soaking;

2) Extraction: Continue to add water that accounts for 8 times the mass of the Poria compound material, start timing after heating to boiling, keep the micro-boiling extraction for 60 min, and filter to obtain the first extract; continue to add water that accounts for 6 times the mass of the Poria compound material to the filter residue , start timing after heating to boiling, keep the micro-boiling extraction for 50 min, and filter to obtain the second extract; continue to add water that accounts for 5 times the mass of the Poria composite material into the filter residue, start timing after heating to boiling, keep the micro-boiling extraction for 40 min, filter The third extraction solution is obtained, the first extraction solution, the second extraction solution and the third extraction solution are combined and passed through a 300-mesh screen to obtain a mixed extraction solution for subsequent use;

3) concentration: the mixed extract is heated and concentrated until the quality of the mixed extract is 0.8 times the quality of the Poria composite material to obtain a concentrated solution;

4) Seasoning: mix the concentrate and seasonings, sterilize them and pack them separately, wherein the seasonings include aspartame, 1.03% sodium cyclamate and 12% xylitol, which account for 1.03% of the mass of the concentrate. Mix the concentrate with aspartame, cyclamate and xylitol evenly.

Example 4

The composition of the present invention is prepared from the following components in parts by weight:

CMP 6kg, yam 3kg, white lentil 3kg, coix seed 3kg, jujube 1.5kg, gorgonian 1.5kg, Amomum 1.5kg, dried ginger 1.5kg, red bean 3kg, orange peel 3kg, hawthorn 1.5kg, malt 1.5kg, Agaricus 3kg, Fragrance 1.5kg, Houttuynia cordata 1.5kg, dandelion 1.5kg, mint 1.5kg, purslane 1.5kg, chicory 1.5kg, perilla leaf 1.5kg, gardenia 1.5kg.

The preparation method of the composition of the present invention comprises the following steps:

S1, 75kg of Poria cocos is coarsely pulverized to 10-200 mesh with a traditional Chinese medicine crusher, to obtain Poria cocos coarse powder, take by weighing the required amount of Poria cocos coarse powder;

1) Put the coarse powder of Poria cocos into the soaking tank, pump 400L of water, stir evenly, and soak for 12h;

2) Slowly pump 400L of sodium hydroxide solution with a concentration of 2.25mol/L into the soaking tank, stir and react for 1h, filter, and take the filtrate;

3) after dropping into the chloroacetic acid solution that 300L concentration is 5.3mol/L in the neutralization tank, slowly add the sodium hydroxide solution that 300L concentration is 6.25mol/L, stir until the reaction is sufficient, be cooled to room temperature;

4) Pump the reaction solution of step 3) into the filtrate obtained in step 2), after fully mixing, slowly heat up to 75°C, and react at constant temperature for 2.5h;

5) adjust the pH value 5.0-7.0 of the reaction solution obtained in step 4) with the hydrochloric acid solution of 6 mol/L, add 95% ethanol equivalent to 3 times the volume of the reaction solution, stir, filter, wash, and get the CMP alcohol eluate;

6) After drying the CMP alcohol eluate at 60°C for 4h, then drying at 105°C for 2h, 37.5kg of CMP crude product was obtained;

7) Disperse 7.5kg of CMP crude product in 250L of double distilled water, add 6mol/L sodium hydroxide solution to adjust the pH to 10.0-13.0; add 1.25L of H ₂ O ₂ solution with a concentration of 30%, decolorize at 15°C for 36h, Remove colored impurities; add 6mol/L hydrochloric acid solution to adjust the pH value to 6.0, centrifuge at 3000 rpm for 30min, take the filtrate, filter the filtrate with a DH-UF hollow fiber ultrafilter to remove CMP with a molecular weight below 0.7×104, and trace amounts of After impurities such as sodium chloride, sodium chloroacetate and sodium glycolate, add 3 times the volume of 95% ethanol to the filtrate, carry out alcohol precipitation, filter or centrifuge, take the CMP alcohol extract and dry it at 60°C for 4 hours, then dry at 105°C 2h, pulverized to obtain 6.0kg pure CMP product with carboxymethyl substitution degree of 1.0:

S2. Pulverize the pure CMP product, pass it through a 60-mesh sieve, add the required amount of other raw materials, mix evenly, and pulverize to 60-140 mesh to obtain a mixed powder, which can be divided into bags and sterilized.

Example 5

The composition of the present invention is prepared from the following components in parts by weight:

CMP 6kg, yam 3kg, white lentil 3kg, coix seed 3kg, jujube 1.5kg, gorgonian 1.5kg, Amomum 1.5kg, dried ginger 1.5kg, red bean 3kg, orange peel 3kg, hawthorn 1.5kg, malt 1.5kg, Agaricus 3kg, Fragrance 1.5kg, Houttuynia cordata 1.5kg, dandelion 1.5kg, mint 1.5kg, purslane 1.5kg, chicory 1.5kg, perilla leaf 1.5kg, gardenia 1.5kg.

The preparation method of the composition of the present invention comprises the following steps:

S1, 75kg of Poria cocos is coarsely pulverized to 10-200 mesh with a traditional Chinese medicine crusher, to obtain Poria cocos coarse powder, take by weighing the required amount of Poria cocos coarse powder;

1) Put the coarse powder of Poria cocos into the soaking tank, pump 400L of water, stir evenly, and soak for 12h;

2) Slowly pump 400L of sodium hydroxide solution with a concentration of 2.25mol/L into the soaking tank, stir and react for 1h, filter, and take the filtrate;

3) after dropping into the chloroacetic acid solution that 300L concentration is 5.3mol/L in the neutralization tank, slowly add the sodium hydroxide solution that 300L concentration is 6.25mol/L, stir until the reaction is sufficient, be cooled to room temperature;

4) Pump the reaction solution of step 3) into the filtrate obtained in step 2), after fully mixing, slowly heat up to 75°C, and react at constant temperature for 2.5h;

5) adjust the pH value 5.0-7.0 of the reaction solution obtained in step 4) with the hydrochloric acid solution of 6 mol/L, add 95% ethanol equivalent to 3 times the volume of the reaction solution, stir, filter, wash, and get the CMP alcohol eluate;

6) After drying the CMP alcohol eluate at 60°C for 4h, then drying at 105°C for 2h, 37.5kg of CMP crude product was obtained;

7) Disperse 7.5kg of CMP crude product in 250L of double distilled water, add 6mol/L sodium hydroxide solution to adjust the pH to 10.0-13.0; add 1.25L of H ₂ O ₂ solution with a concentration of 30%, decolorize at 15°C for 36h, Remove colored impurities; add 6mol/L hydrochloric acid solution to adjust the pH value to 6.0, centrifuge at 3000 rpm for 30min, take the filtrate, and filter the filtrate with a DH-UF hollow fiber ultrafilter to remove CMP with a molecular weight below 0.7×10 ⁴ , and trace amounts After removing impurities such as sodium chloride, sodium chloroacetate and sodium glycolate, add 3 times of filtrate volume of 95% ethanol to the filtrate, carry out alcohol precipitation, filter or centrifuge, take the CMP alcohol extract and dry it at 60 °C for 4 hours, then dry it at 105 °C. Dry for 2h and pulverize to obtain 6.0kg of CMP pure product with a degree of carboxymethyl substitution of 1.0:

S2. Pulverize the pure CMP product and pass through a 60-mesh sieve.

S3, other raw materials of required amount in the CMP, add water that accounts for 8 times of the quality of the Poria cocos composite, and soak the Poria mixture for 60min after stirring and soaking;

S4. Continue to add water that accounts for 8 times the mass of the Poria composite material, start timing after heating to boiling, keep the micro-boiling extraction for 60 min, and filter to obtain the first extract; continue to add water that accounts for 6 times the mass of the Poria composite material to the filter residue, and heat Start timing after boiling, keep the micro-boiling extraction for 50 min, and filter to obtain the second extract; continue to add water that accounts for 5 times the mass of the Poria composite material to the filter residue, heat to boiling and start timing, keep the micro-boiling extraction for 40 min, and filter to obtain the first solution. Three extraction solutions, combine the first extraction solution, the second extraction solution and the third extraction solution and pass through a 300-mesh sieve to obtain a mixed extraction solution for subsequent use;

S5, the mixed extract is heated and concentrated until the quality of the mixed extract is 0.8 times the quality of the Poria composite material to obtain a concentrated solution;

S6. Mix the concentrate and seasonings, sterilize them, and pack them separately. The seasonings include 1.03% aspartame, 1.03% cyclamate and 12% xylitol, which account for 1.03% of the quality of the concentrate. The concentrate is mixed with aspartame, cyclamate and xylitol.

Example 6

The composition of the present invention is prepared from the following components in parts by weight:

CMP 6kg, yam 3kg, white lentil 3kg, coix seed 3kg, jujube 1.5kg, gorgonian 1.5kg, Amomum 1.5kg, dried ginger 1.5kg, red bean 3kg, orange peel 3kg, hawthorn 1.5kg, malt 1.5kg, Agaricus 3kg, Fragrance 1.5kg, Houttuynia cordata 1.5kg, dandelion 1.5kg, mint 1.5kg, purslane 1.5kg, chicory 1.5kg, perilla leaf 1.5kg, gardenia 1.5kg.

The preparation method of the composition of the present invention comprises the following steps:

S1, 75kg of Poria cocos is coarsely pulverized to 10-200 mesh with a traditional Chinese medicine crusher, to obtain Poria cocos coarse powder, take by weighing the required amount of Poria cocos coarse powder;

1) Put the coarse powder of Poria cocos into the soaking tank, pump 400L of water, stir evenly, and soak for 12h;

2) Slowly pump 400L of sodium hydroxide solution with a concentration of 2.25mol/L into the soaking tank, stir and react for 1h, filter, and take the filtrate;

3) drop into the chloroacetic acid solution that 300L concentration is 5.3mol/L in the neutralization tank, then slowly add the sodium hydroxide solution that 300L concentration is 6.25mol/L, stir until the reaction is sufficient, be cooled to room temperature;

4) Pump the reaction solution of step 3) into the filtrate obtained in step 2), after fully mixing, slowly heat up to 75°C, and react at constant temperature for 2.5h;

5) adjust the pH value 5.0-7.0 of the reaction solution obtained in step 4) with the hydrochloric acid solution of 6 mol/L, add 95% ethanol equivalent to 3 times the volume of the reaction solution, stir, filter, wash, and get the CMP alcohol eluate;

6) After drying the CMP alcohol eluate at 60°C for 4h, then drying at 105°C for 2h, 37.5kg of CMP crude product was obtained;

7) Disperse 7.5kg of CMP crude product in 250L of double distilled water, add 6mol/L sodium hydroxide solution to adjust the pH to 10.0-13.0; add 1.25L of H ₂ O ₂ solution with a concentration of 30%, decolorize at 15°C for 36h, Remove colored impurities; add 6mol/L hydrochloric acid solution to adjust the pH value to 6.0, centrifuge at 3000 rpm for 30min, take the filtrate, filter the filtrate with a DH-UF hollow fiber ultrafilter to remove CMP with a molecular weight below 0.7×104, and trace amounts of After impurities such as sodium chloride, sodium chloroacetate and sodium glycolate, add 3 times the volume of 95% ethanol to the filtrate, carry out alcohol precipitation, filter or centrifuge, take the CMP alcohol extract and dry it at 60°C for 4 hours, then dry at 105°C 2h, pulverized to obtain 6.0kg pure CMP product with carboxymethyl substitution degree of 1.0:

S2. Pulverize the pure CMP product and pass through a 60-mesh sieve.

S3, other raw materials of required amount in the CMP, add water that accounts for 8 times of the quality of the Poria cocos composite, and soak the Poria mixture for 60min after stirring and soaking;

S4. Continue to add water that accounts for 8 times the mass of the Poria composite material, start timing after heating to boiling, keep the micro-boiling extraction for 60 min, and filter to obtain the first extract; continue to add water that accounts for 6 times the mass of the Poria composite material to the filter residue, heat Start timing after boiling, keep the micro-boiling extraction for 50 min, and filter to obtain the second extract; continue to add water that accounts for 5 times the mass of the Poria cocos composite material to the filter residue, start timing after heating to boiling, keep the micro-boiling extraction for 40 min, and filter to obtain the first solution. Three extraction solutions, combine the first extraction solution, the second extraction solution and the third extraction solution and pass through a 300-mesh sieve to obtain a mixed extraction solution for subsequent use;

S5, the mixed extract is heated and concentrated until the quality of the mixed extract is 0.8 times the quality of the Poria composite material to obtain a concentrated solution;

S6. Mix the concentrate and seasonings, sterilize them and pack them separately. The seasonings include 1.03% of aspartame, 1.03% of sodium cyclamate and 12% of xylitol, which account for 1.03% of the quality of the concentrate. The concentrate is mixed with aspartame, cyclamate and xylitol.

S7. Add soluble starch or maltodextrin or a mixture of the two to the seasoned Poria compound powder so that the overall mass is 20 times that of the Poria compound powder, and then use 60% to 80% ethanol solution to granulate by wet mixing The Poria health-care granules are obtained by granulating in the machine, and the Poria health-care granules are sterilized and then packaged in bags.

Test Example 1 Taste Test

1. Drinking crowd: the general population

2. Drinking time: 10 am

3. Number of people drinking: 200 people, 100 people in each group

4. Method: Take 10g of the compositions obtained in Example 1 and Example 4, and need 200mL of boiling water for brewing. The brewing time is 15-20min in the thermos cup, taste at ten o'clock in the morning, and fast for one hour before tasting. food.

5. Indicators: After drinking, it is obvious that it is clear and slightly bitter and has a sweet taste. It is good to have a fresh aroma. After drinking, it is clear and slightly bitter and sweet, and the aroma is not obvious. It is recorded as normal. What is unacceptable is recorded as poor.

6. The results of the taste test are shown in Table 1.

Table 1

good taste (crowd) Average taste (crowd) Bad taste (crowd) Example 1 80 18 2 Example 4 92 8 0

Test Example 2 Efficacy Comparison Test

1. Drinking crowd: People who are prone to abdominal distension and indigestion after meals

2. Drinking time: take one bag in the morning and half an hour later in the evening, for 15 consecutive days

3. Number of people drinking: 100 people in total, 50 people in each group

4. Method: Take 10g of each of the compositions obtained in Example 1 and Example 4, 200mL of boiling water is required for brewing, the brewing time is 15-20min in a thermos cup, and the drinking time is once in the morning and once in the evening, half an hour after meals drink.

5. Indicators: After 15 days of continuous use, the symptoms of abdominal distension and indigestion have disappeared completely, and the mental state has been improved, which is significantly effective; after 15 days of continuous use, the phenomenon of abdominal distension and indigestion is relieved, and the mental state is the same as before, it is generally effective; continuous use After 15 days, the symptoms of abdominal distension and indigestion are not relieved or even aggravated, and the mental state deteriorates as invalid.

The data were expressed as mean±standard deviation (X±S), enumeration data using X2 test, rank data using Ridit analysis, measurement data using t test. The results are shown in Table 2.

Table 2

group Number of cases Temporary control (example) Effective (example) Valid (example) invalid (example) Total Efficiency (%) Example 1 50 0 28 15 7 86* Example 4 50 0 39 11 0 100*

Note: *P<0.01

The above description of the specific embodiments of the present invention does not limit the present invention, and those skilled in the art can make various changes or deformations according to the present invention, as long as they do not depart from the spirit of the present invention, they should all belong to the scope of protection of the claims of the present invention.

Claims (10)

1. The poria cocos medicinal composition with the effects of invigorating stomach and eliminating spleen is characterized by comprising the following raw materials in parts by weight: 4-8 parts of poria cocos, 2-5 parts of Chinese yam, 2-5 parts of white hyacinth bean, 2-4 parts of coix seed, 1-3 parts of Chinese date, 1-3 parts of gordon euryale seed, 1-3 parts of fructus amomi, 1-3 parts of dried ginger, 1-4 parts of phaseolus calcaratus, 1-5 parts of orange peel, 1-3 parts of hawthorn, 1-2 parts of malt, 1-4 parts of wrinkled gianthyssop herb, 1-3 parts of elsholtzia, 1-3 parts of heartleaf houttuynia herb, 1-3 parts of dandelion, 1-3 parts of mint, 1-3 parts of purslane, 1-3 parts of chicory, 1-3 parts of perilla leaf and 1-3 parts of cape jasmine.

2. The composition according to claim 1, wherein the poria cocos in the composition is any one of poria cocos coarse powder, pachyman alkalized extract, pachyman, and high-substitution-degree carboxymethyl pachyman (CMP).

3. The composition according to any one of claims 1-2, wherein said highly substituted carboxymethyl pachyman is prepared by a method comprising the steps of: 1) Adding pachymaran into water or water-alcohol mixed solution, stirring, adding alkaline solution with a mass of 1-8% of pachymaran, and stirring to completely dissolve to obtain pachymaran alkalized solution; 2) And (2) after fully reacting 1.0-10mol/L chloroacetic acid with proper excess 2.0-10mol/L alkaline solution, adding the obtained product into the pachyman alkalization solution obtained in the step 1), and performing substitution reaction, separation and purification to obtain the pachyman alkalization solution, wherein the proper excess is that the actual dosage of alkaline substances in the alkaline solution is 0.5-40% more than the theoretical dosage required by the neutralization reaction between the alkaline substances and chloroacetic acid.

4. The composition according to any one of claims 1-3, wherein the pachyman in step 1) is selected from the group consisting of an alkalized extract of pachyman obtained by alkalization extraction or a crude pachyman obtained by acid precipitation with alkali extraction.

5. The composition according to any one of claims 1 to 4, wherein the pachyman alkalizing extract is prepared by adding Poria cocos powder into an alkaline solution having a concentration of 1.0-4.0mol/L to conduct alkalizing extraction, centrifuging, and collecting the supernatant.

6. The composition according to any one of claims 1 to 5, wherein the pachyman is prepared by extracting Poria cocos powder with an alkaline solution having a concentration of 1.0-4.0mol/L under stirring, centrifuging, and collecting the supernatant; adding acid into the supernatant, centrifuging the obtained acid precipitate, and washing with water to obtain pachyman, wherein the acid is selected from one of acetic acid, hydrochloric acid, sulfuric acid, and nitric acid.

7. The composition according to any one of claims 1 to 6, wherein the composition further comprises a desired amount of a pharmaceutically acceptable carrier selected from any one of or a combination of fillers, lubricants, dispersants, wetting agents, binders, conditioning agents, solubilizers, antioxidants, emulsifiers, flavoring agents, and perfuming agents.

8. The composition according to any one of claims 1 to 7, wherein the composition comprises the following raw materials in parts by weight: 4 parts of poria cocos, 2 parts of Chinese yam, 2 parts of white hyacinth beans, 2 parts of coix seeds, 1 part of Chinese dates, 1 part of gordon euryale seeds, 1 part of fructus amomi, 1 part of dried ginger, 2 parts of phaseolus calcaratus, 2 parts of orange peels, 1 part of hawthorn fruits, 1 part of malt, 2 parts of agastache rugosus, 1 part of elsholtzia, 1 part of houttuynia cordata, 1 part of dandelion, 1 part of mint, 1 part of purslane, 1 part of chicory, 1 part of perilla leaves and 1 part of cape jasmine fruits.

9. The preparation method of the poria cocos medicinal composition with stomach and spleen invigorating effects according to any one of claims 1 to 8, wherein the composition comprises the following raw materials in parts by weight: 4-8 parts of poria cocos, 2-5 parts of Chinese yam, 2-5 parts of white hyacinth bean, 2-4 parts of coix seed, 1-3 parts of Chinese date, 1-3 parts of gordon euryale seed, 1-3 parts of fructus amomi, 1-3 parts of dried ginger, 1-4 parts of phaseolus calcaratus, 1-5 parts of orange peel, 1-3 parts of hawthorn, 1-2 parts of malt, 1-4 parts of wrinkled gianthyssop herb, 1-3 parts of elsholtzia, 1-3 parts of heartleaf houttuynia herb, 1-3 parts of dandelion, 1-3 parts of mint, 1-3 parts of purslane, 1-3 parts of chicory, 1-3 parts of perilla leaf and 1-3 parts of gardenia, and the specific preparation method comprises the following steps: all the raw materials are evenly mixed and crushed to 60 to 140 meshes, and then the mixture is sterilized to obtain the feed.

10. Use of the poria cocos pharmaceutical composition as defined in any one of claims 1-8 or the composition prepared by the method as defined in claim 9 for the preparation of a product for improving gastrointestinal function.