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CN115201470A - Antigen detection reagent card with more stable connectivity - Google Patents

Antigen detection reagent card with more stable connectivity Download PDF

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Publication number
CN115201470A
CN115201470A CN202211118467.7A CN202211118467A CN115201470A CN 115201470 A CN115201470 A CN 115201470A CN 202211118467 A CN202211118467 A CN 202211118467A CN 115201470 A CN115201470 A CN 115201470A
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CN
China
Prior art keywords
upper shell
pressing block
test paper
shell
connecting column
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Granted
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CN202211118467.7A
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Chinese (zh)
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CN115201470B (en
Inventor
闵少颖
孙睿佳
郭宣城
高精梓
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Shandong Biobase Diagnosis Technology Co ltd
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Shandong Biobase Diagnosis Technology Co ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54386Analytical elements
    • G01N33/54387Immunochromatographic test strips

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention discloses an antigen detection reagent card with more stable connectivity, belonging to the field of microbial detection; the test paper detection device comprises an upper shell, a lower shell and test paper, wherein at least one window is formed in the upper shell, and a detection area on the test paper is aligned with the window; a connecting component is arranged between the lower shell and the upper shell; the connecting component comprises a connecting column arranged on the upper shell and a connecting cylinder arranged on the lower shell; the connecting column is rotatably connected with the upper shell, a spiral bulge with a large inclination angle is arranged on the connecting column, and a spiral groove is formed in the inner wall of the connecting cylinder; the lower surface of the upper shell is also provided with a pressing block, the pressing block can move along the width direction of the upper shell, one end of the pressing block is arranged close to the edge of the upper shell, and the other end of the pressing block can be pressed on the test paper; the spliced pole cover is equipped with the drive block, and drive block and spliced pole threaded connection, the in-process drive briquetting lateral shifting that the drive block can move down. The test paper fixing device has the effect of enabling the upper shell, the lower shell and the test paper to be installed more stably.

Description

Antigen detection reagent card with more stable connectivity
Technical Field
The invention relates to the field of microbial detection, in particular to an antigen detection reagent card with more stable connectivity.
Background
The new crown epidemic situation is serious at present, and in order to facilitate detection, the detection of antigens can be carried out besides nucleic acid detection; in order to facilitate personal detection, a reagent card is generally adopted for detection, a collected sample is smeared on a detection area on the reagent card, and the purpose of detection is achieved by observing the color change reaction of the detection area.
The existing reagent card generally comprises an upper shell and a lower shell, the test paper is positioned between the upper shell and the lower shell, the upper shell and the lower shell fix the test paper, and a supporting structure in the lower shell supports the test paper, so that the test paper is easy to sink under thrust in the smearing process, and smearing of a sample is influenced.
Disclosure of Invention
In order to facilitate the use of the reagent card, the application provides an antigen detection reagent card with more stable connectivity, which adopts the following technical scheme:
an antigen detection reagent card with more stable connectivity comprises an upper shell, a lower shell and test paper, wherein the upper shell is provided with at least one window, and a detection area on the test paper is aligned with the window; a connecting assembly is arranged between the lower shell and the upper shell;
the connecting assembly comprises a connecting column arranged on the upper shell and a connecting cylinder arranged on the lower shell, and at least one connecting column and at least one connecting cylinder are arranged on the connecting column;
the connecting column is rotatably connected with the upper shell, so that the connecting column can rotate along the axis of the connecting column, the outer wall of the connecting column is spirally and fixedly connected with a spiral bulge with a large inclination angle, and the inner wall of the connecting cylinder is provided with a spiral groove with a large inclination angle;
the lower end of the connecting column is fixedly connected with a coaxially arranged threaded column, the bottom surface of the connecting cylinder is provided with a threaded hole, and the threaded column is in threaded connection with the threaded hole;
the lower surface of the upper shell is also provided with a pressing block, the pressing block can move along the width direction of the upper shell, one end of the pressing block is arranged close to the edge of the upper shell, and the other end of the pressing block can be pressed on the test paper;
the spliced pole cover is equipped with the drive block, and drive block and spliced pole threaded connection, the in-process drive briquetting lateral shifting that the drive block can move down.
By adopting the technical scheme, when the upper shell and the lower shell are buckled together, the connecting column can rotate, and the connecting column rotates in the process of entering the connecting cylinder due to the matching of the guide thread groove and the guide thread bulge, so that the threaded column is driven to rotate, the threaded column rotates into the threaded hole, and the threaded column is in threaded connection with the threaded hole, so that the connecting cylinder and the connecting column are stably connected together, and the lower shell and the upper shell cannot be easily separated;
meanwhile, the driving block can move downwards when the connecting column rotates due to the threaded fit of the driving block and the connecting column, the moving block is driven to move downwards to drive the pressing block to move transversely, the end part of the pressing block can move above the test paper due to the transverse movement of the pressing block, so that the test paper is pressed and fixed, the test paper is prevented from sinking when a sample is smeared, and the use of a reagent card is not influenced;
the briquetting gets the upper surface that the lower surface is less than on the test paper, so when the briquetting compressed tightly the test paper, the briquetting pressed simultaneously on the bearing structure on last casing, can apply an ascending power to last casing, and screw post and screw hole link together this moment, the holding power that the briquetting produced is opposite with screw post, the power that the screw hole produced, can produce the interact power, and then make the briquetting fixed more stable to fixed subassembly, and at the in-process of lock, still can not produce too big resistance.
Optionally, the threaded hole penetrates through the lower shell, and a cross-shaped stress groove is formed in the lower end of the threaded column.
By adopting the technical scheme, the threaded column can rotate out of the threaded hole through the stress groove, and the connecting column is pushed to move away from the connecting cylinder, so that a gap is generated between the upper shell and the lower shell, and the lower shell and the upper shell can be conveniently opened.
Optionally, the lower surface of the driving block is an inclined surface, the inclined lower end of the inclined surface is arranged close to the edge of the upper shell, and the inclined surface can be abutted to the end of the pressing block.
Through adopting above-mentioned technical scheme, the drive block that has the inclined plane can exert thrust to the one end of briquetting at the in-process that descends to promote the briquetting and remove towards the direction of test paper, the briquetting realizes the fixed to the test paper, and this in-process goes on simultaneously along with the lock of last casing, lower casing, need not go alone and orders about the drive block, need not carry out extra operation, convenient and fast more.
Optionally, a T-shaped groove is formed in the upper surface of the pressing block, a T-shaped block is fixedly connected to the inner top surface of the upper shell, and the T-shaped block is in sliding fit with the T-shaped groove.
Through adopting above-mentioned technical scheme, through the cooperation in T type piece and T type groove, can make briquetting and last casing sliding connection together, the drive block can drive the briquetting and remove, still can not lead to briquetting and last casing to produce the separation, makes briquetting and last casing connect more stable.
Optionally, a yielding groove is formed in the upper surface of one end, far away from the driving block, of the pressing block, and the upper surface of the pressing block can not interfere with the protruding part of the top of the upper shell through the yielding groove.
Through adopting above-mentioned technical scheme, because the window has been seted up to last casing, so the inside top surface of going up the casing has the arch, and the groove of stepping down can make the briquetting can not produce with the outstanding part of last casing and interfere to the removal that makes the briquetting can not receive the influence.
Optionally, the end of the pressing block close to one end of the driving block is fixedly connected with a plurality of springs, and one end of each spring far away from the driving block is fixedly connected to the side wall inside the upper shell.
Through adopting above-mentioned technical scheme, when the briquetting removed, the spring atress was tensile, and the spring holds the power, and when the test paper was changed to needs, the reversal spliced pole can make screw thread post and screw hole break away from to make casing and lower casing physical separation down, and at spliced pole pivoted in-process, the drive block rose, no longer to the briquetting application of force, the spring can stimulate the briquetting answer normal position, makes things convenient for the follow-up reuse of briquetting.
Optionally, a plurality of round holes are formed in the end portion, close to one end of the driving block, of the pressing block, the spring is located in the round hole, and the spring is fixedly connected to the bottom face of the round hole.
Through adopting above-mentioned technical scheme, the existence of round hole can make the longer spring of installation length on the briquetting to make the life of spring longer.
In view of the above, it is desirable to provide,
1. after the upper shell and the lower shell are buckled, the driving block can drive the press block to move to the test paper for fixing, the lower surface of the press block is lower than the upper surface of the test paper, so that the press block can fix the test paper, the test paper cannot sink, and meanwhile, because the press block is perpendicular to the force generated by the threaded column and the threaded hole, the press block can fix the test paper more tightly, and excessive resistance cannot be caused to the buckling of the upper shell and the lower shell;
2. the groove of stepping down on the briquetting can make the in-process that the briquetting removed can not produce with outstanding part on the last casing and interfere, makes the briquetting normally remove, is equipped with the spring on the briquetting simultaneously, and when going up casing and casing separation down, the spring can make the briquetting get back to initial position.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a reagent card according to the first embodiment.
FIG. 2 is an exploded view of a reagent card according to the first embodiment.
FIG. 3 is a sectional view of a highlighted compact in the second example.
Figure 4 is a cross-sectional view highlighting the relationship of the connector barrel and the connecting post of the second embodiment.
FIG. 5 is a sectional view showing the position of the fixing member according to the second embodiment.
Fig. 6 is an enlarged view of a portion a in fig. 5.
FIG. 7 is a schematic structural diagram of the highlighted T-block in the embodiment.
Description of reference numerals:
1. a lower housing; 11. a connecting cylinder; 111. a guide thread groove; 112. a threaded hole; 12. supporting ribs; 13. positioning a plate; 14. a flange plate; 2. an upper housing; 21. a window; 22. connecting columns; 221. a guide thread bulge; 222. a threaded post; 223. a stress slot; 23. a T-shaped block; 3. test paper; 4. a fixing component; 41. pressing into blocks; 411. a T-shaped groove; 412. a groove; 413. a yielding groove; 414. chamfering; 42. a drive block; 421. a bevel; 43. a circular hole; 44. a spring.
Detailed Description
Example one
An antigen detection reagent card with more stable connectivity, referring to fig. 1 and 2, comprises a lower casing 1, an upper casing 2, and a test paper 3 arranged between the lower casing 1 and the upper casing 2; the lower case 1 and the upper case 2 can be buckled together, thereby clamping the test paper 3; at least one window 21 is formed in the upper shell 2, and a detection area on the test paper 3 is just aligned with the window 21, so that a cotton swab with a sample is smeared on the test paper through the window 21 during detection, and the reaction of the test paper is observed.
Referring to fig. 2, the upper surface of the lower casing 1 is fixedly connected with a plurality of connecting cylinders 11, the lower surface of the upper casing 2 is fixedly connected with a plurality of connecting columns 22, the connecting cylinders 11 and the connecting columns 22 are correspondingly inserted one by one, and the connecting cylinders 11 and the connecting columns 22 are uniformly distributed around the edge of the upper casing 2; connecting cylinder 11 and spliced pole 22 interference fit to can link together upper casing 2 and lower casing 1, be convenient for carry out the centre gripping to test paper 3 and fix.
Referring to fig. 2, a support rib 12 is further fixedly connected to the upper surface of the lower housing 1, the support rib 12 is located in the middle of the lower housing 1 in the width direction, and the support rib 12 can support the test paper 3, so that the test paper 3 can be conveniently mounted and fixed. The both ends of test paper 3 still are equipped with a plurality of locating plates 13 of fixed connection on casing 1 down, and a plurality of locating plates 13 are located the tip and the both sides of test paper 3 to can carry on spacingly to test paper 3, reduce the probability that test paper 3 produced the removal, thereby make the detection zone on the test paper 3 can align with window 21.
Referring to fig. 2, the homogeneous body shaping in edge of casing 1 and last casing 2 has flange 14 down, flange 14 is located casing 1 and last casing 2 each other near on the surface down, and flange 14 is perpendicular to casing 1 down, go up casing 2's surface, flange 14 centers on casing 1 down, go up casing 2's marginal round, go up casing 2, casing 1 lock back down, the tip laminating of two flange 14, can be to last casing 2, the space in casing 1 shape groove shelters from sealedly down, increase the aesthetic property, can also prevent the entering of dust, make the use of test paper can not receive the influence.
Example two
Referring to fig. 3 and 4, the present embodiment is different from the previous embodiment in that:
in this example, the connection column 22 is rotatably connected to the upper casing 2 such that the connection column 22 can rotate along its axis. The connecting cylinder 11 is internally provided with a guide thread groove 111, the connecting column 22 is fixedly connected with a guide thread bulge 221, and the inclination angles of the guide thread groove 111 and the guide thread bulge 221 are large, so that in the process of inserting the connecting column 22 into the connecting cylinder 11, the guide thread groove 111 and the guide thread bulge 221 are matched to drive the connecting column 22 to rotate.
Referring to fig. 3 and 4, a threaded hole 112 is formed in the bottom surface of the connecting cylinder 11, the threaded hole 112 penetrates through the bottom of the lower shell 1, a threaded post 222 is fixedly connected to one end, away from the upper shell 2, of the connecting post 22, and the threaded post 222 can rotate along with the connecting post 22, so that the connecting post 22 rotates to drive the threaded post 222 to rotate into the threaded hole 112, the threaded post 222 is in threaded connection with the threaded hole 112, the connecting post 22 can be installed in the connecting cylinder 11, and the upper shell 2 and the lower shell 1 are stably connected together.
Referring to fig. 3 and 4, the cross-shaped stress groove 223 is opened at the end of the threaded column 222 far away from the connection column 22, when the upper shell 2 needs to be disassembled and the lower shell 1 needs to be disassembled, only the force is applied to the threaded column 222 through the stress groove 223, the threaded column 222 is driven to rotate, the threaded column 222 is rotated out of the threaded hole 112, meanwhile, the connection column 22 is driven to move far away from the lower shell 1, namely, when the threaded column 222 rotates out of the threaded hole 112, the connection column 22 can also be driven to move, the lower shell 1 and the upper shell 2 are enabled to generate a gap, and the lower shell 1 and the upper shell 2 are also convenient to open.
Referring to fig. 4 and 5, the inside of the upper shell 2 is provided with a plurality of groups of fixing components 4, and the fixing components 4 can assist in fixing the test paper 3, so that the test paper 3 can be installed more stably, and the movement in the process of smearing a sample is avoided.
Referring to fig. 5 and 6, the fixing assembly 4 includes two pressing blocks 41 and two driving blocks 42, the pressing blocks 41 are symmetrically arranged, the pressing blocks 41 are slidably connected to the inner top surface of the upper casing 2, one ends of the two pressing blocks 41, which are close to each other, can press the upper surface of the test paper 3, the two driving blocks 42 are respectively located at one ends of the two pressing blocks 41, which are away from each other, and the driving blocks 42 can drive the pressing blocks 41 to move so as to press the test paper 3.
Referring to fig. 7, a T-shaped groove 411 is formed in the upper surface of the pressing block 41, a T-shaped block 23 is fixedly connected to the inner top surface of the upper housing 2, and the T-shaped block 23 and the T-shaped groove 411 are matched with each other, so that the pressing block 41 is slidably connected with the upper housing 2.
Referring to fig. 6 and 7, the driving block 42 is sleeved on the connecting column 22, the driving block 42 is in threaded fit with the connecting column 22, a groove 412 is formed in one end, close to the flange plate 14, of the pressing block 41, the lower end of the driving block 42 is located in the groove 412, so that the driving block 42 is limited by the pressing block 41, the driving block 42 cannot rotate along with the connecting column 22, and therefore the driving block 42 can move downwards in the rotating process of the connecting column.
Referring to fig. 6 and 7, the lower surface of the driving block 42 is an inclined surface 421, and the inclined lower end of the inclined surface 421 is disposed close to the flange 14, so that in the process that the driving block 42 moves downward, under the action of the inclined surface 421, the pressing block 41 can be pushed to move, the end portion of the pressing block 41 far from the flange 14 is pressed on the test paper 3, the test paper 3 is fixed, and the test paper 3 is prevented from moving.
Referring to fig. 6 and 7, a plurality of circular holes 43 are further formed in one end of the driving block 42 close to the flange 14, springs 44 are fixedly connected in the circular holes 43, and one ends of the springs 44 protruding out of the end of the driving block 42 are fixedly connected with the flange 14. After the driving block 42 drives the pressing block 41 to move towards the direction of the test paper 3, the pressing block 41 is pressed on the test paper, meanwhile, the spring 44 is stressed to extend, when the test paper 3 needs to be replaced, the connecting column 22 is driven to rotate reversely through the stress groove 223, the connecting column 22 is separated from the connecting cylinder 11, the driving block 42 is in threaded fit with the connecting column 22 at the moment, the driving block 42 does not apply thrust to the pressing block 41 any more, and then the pressing block 41 can return to the initial position again under the action of the spring 44 in a contracting mode.
Referring to fig. 7, the upper surface of one end of the pressing block 41 close to the test paper 3 is provided with an abdicating groove 413, and the abdicating groove 413 can prevent the end of the pressing block 41 from interfering with the protruding part at the top of the upper shell 2 in the moving process, so that the moving of the pressing block 41 is not affected.
Referring to fig. 7, a chamfer 414 is formed at an edge of a lower surface of the pressing block 41 near the end of the test paper 3, and the lower surface of the pressing block is lower than the upper surface of the test paper 3, so that the pressing block 41 can press the test paper more stably, and the chamfer 414 can prevent the pressing block 41 and the test paper 3 from interfering.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: equivalent changes in structure, shape and principle of the present application shall be covered by the protection scope of the present application.

Claims (7)

1. An antigen detection reagent card with more stable connectivity comprises an upper shell (2), a lower shell (1) and test paper (3), wherein at least one window (21) is formed in the upper shell (2), and a detection area on the test paper (3) is aligned to the window (21); the method is characterized in that: a connecting component is arranged between the lower shell (1) and the upper shell (2);
the connecting assembly comprises a connecting column (22) arranged on the upper shell (2) and a connecting cylinder (11) arranged on the lower shell (1), and at least one of the connecting column (22) and the connecting cylinder (11) is arranged;
the connecting column (22) is rotatably connected with the upper shell (2), so that the connecting column (22) can rotate along the axis of the connecting column (22), the outer wall of the connecting column (22) is spirally and fixedly connected with a spiral bulge with a large inclination angle, and the inner wall of the connecting cylinder (11) is provided with a spiral groove (412) with a large inclination angle;
the lower end of the connecting column (22) is fixedly connected with a coaxially arranged threaded column (222), the bottom surface of the connecting cylinder (11) is provided with a threaded hole (112), and the threaded column (222) is in threaded connection with the threaded hole (112);
the lower surface of the upper shell (2) is further provided with a pressing block (41), the pressing block (41) can move along the width direction of the upper shell (2), one end of the pressing block (41) is arranged close to the edge of the upper shell (2), and the other end of the pressing block (41) can be pressed on the test paper (3);
the connecting column (22) is sleeved with a driving block (42), the driving block (42) is in threaded connection with the connecting column (22), and the driving block (42) can drive the pressing block (41) to transversely move in the downward moving process.
2. The antigen detection reagent card with more stable connectivity according to claim 1, wherein: the threaded hole (112) penetrates through the lower shell (1), and the lower end of the threaded column (222) is provided with a cross-shaped stress groove (223).
3. The antigen detection reagent card with more stable connectivity according to claim 1, wherein: the lower surface of the driving block (42) is an inclined surface (421), the inclined lower end of the inclined surface (421) is arranged close to the edge of the upper shell (2), and the inclined surface (421) can be abutted to the end of the pressing block (41).
4. The reagent card for antigen detection with more stable connectivity according to claim 1, wherein: t type groove (411) have been seted up to the upper surface of briquetting (41), go up the inside top surface fixedly connected with T type piece (23) of casing (2), T type piece (23) and T type groove (411) sliding fit.
5. The antigen detection reagent card with more stable connectivity according to claim 1, wherein: the upper surface of one end, far away from the driving block (42), of the pressing block (41) is provided with a yielding groove (413), and the yielding groove (413) can enable the upper surface of the pressing block (41) not to interfere with the protruding part of the top of the upper shell (2).
6. The reagent card for antigen detection with more stable connectivity according to claim 1, wherein: the end part of the pressing block (41) close to one end of the driving block (42) is fixedly connected with a plurality of springs (44), and one end, far away from the driving block (42), of each spring (44) is fixedly connected to the side wall inside the upper shell (2).
7. The antigen detection reagent card with more stable connectivity according to claim 6, wherein: a plurality of round holes (43) are formed in the end portion, close to one end of the driving block (42), of the pressing block (41), the spring (44) is located in the round holes (43), and the spring (44) is fixedly connected to the bottom face of the round holes (43).
CN202211118467.7A 2022-09-15 2022-09-15 Antigen detection reagent card with more stable connectivity Active CN115201470B (en)

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CN115201470B CN115201470B (en) 2022-12-13

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