CN115154492A - Preparation method of ginkgo leaf extract - Google Patents
Preparation method of ginkgo leaf extract Download PDFInfo
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- CN115154492A CN115154492A CN202211020593.9A CN202211020593A CN115154492A CN 115154492 A CN115154492 A CN 115154492A CN 202211020593 A CN202211020593 A CN 202211020593A CN 115154492 A CN115154492 A CN 115154492A
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- 239000009429 Ginkgo biloba extract Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 59
- 238000001035 drying Methods 0.000 claims abstract description 27
- 239000000284 extract Substances 0.000 claims abstract description 26
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 24
- 241000218628 Ginkgo Species 0.000 claims abstract description 24
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 24
- 230000002441 reversible effect Effects 0.000 claims abstract description 20
- 238000000605 extraction Methods 0.000 claims abstract description 14
- 238000007599 discharging Methods 0.000 claims abstract description 13
- 230000002195 synergetic effect Effects 0.000 claims abstract description 13
- 238000005485 electric heating Methods 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 42
- 230000005540 biological transmission Effects 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 238000010025 steaming Methods 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 11
- 229940068052 ginkgo biloba extract Drugs 0.000 claims description 11
- 235000020686 ginkgo biloba extract Nutrition 0.000 claims description 11
- 238000010298 pulverizing process Methods 0.000 claims description 11
- 238000010992 reflux Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 239000008234 soft water Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 238000009423 ventilation Methods 0.000 claims description 2
- 229940126680 traditional chinese medicines Drugs 0.000 claims 1
- 239000012535 impurity Substances 0.000 abstract description 4
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 3
- 230000007721 medicinal effect Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 description 8
- 238000000638 solvent extraction Methods 0.000 description 5
- 230000005484 gravity Effects 0.000 description 3
- 210000001503 joint Anatomy 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 2
- 230000003028 elevating effect Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/08—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers
- B02C18/12—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers with drive arranged below container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/16—Details
- B02C18/24—Drives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- Natural Medicines & Medicinal Plants (AREA)
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- Pharmacology & Pharmacy (AREA)
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Abstract
The invention discloses a preparation method of a ginkgo leaf extract, which comprises a crushing bin, an airflow type drying mechanism, a swinging type synergistic mechanism, a power type reverse mechanism and a twisting type collecting mechanism, wherein the lower side of the crushing bin is connected with a support frame, the crushing bin is connected with a feeding and discharging pipe, the airflow type drying mechanism is arranged in the crushing bin and is used for assisting the drying of traditional Chinese medicinal materials, the airflow type drying mechanism comprises a pressure dividing air bin, an electric heating wire is connected in the pressure dividing air bin, an air pump is connected on the crushing bin, and the swinging type synergistic mechanism is arranged in the crushing bin and is used for increasing the contact area between the traditional Chinese medicinal materials and drying airflow. The invention reduces the loss of the effective components of the ginkgo leaf extract, greatly improves the medicinal value of the ginkgo leaf, improves the extraction speed, is more suitable for large-scale production, reduces the impurities in the extract, improves the medicinal effect of the ginkgo leaf extract and improves the quality of the ginkgo leaf extract by improving the ginkgo leaf extraction method.
Description
Technical Field
The invention belongs to the technical field of crushers, and particularly relates to a preparation method of a ginkgo leaf extract.
Background
Traditional chinese medicine rubbing crusher is a machine for smashing traditional chinese medicine, and traditional chinese medicine material grinder generally adopts hypervelocity single phase motor as power, can smash various soft and hard medicinal materials fast, is the indispensable instrument of pounding medicine in pharmacy in modern, can replace traditional mortar of pounding medicine, and work efficiency promotes greatly in manual pounding medicine, and most traditional chinese medicine all need dry before going into medicine and smash, and this not only convenient storage can also reduce the loss of drug effect.
The traditional methods for extracting the effective components from the medicinal plants include solvent extraction, steam distillation, sublimation, etc.
At present, a solvent extraction method is generally adopted when folium ginkgo components are extracted, although the solvent extraction method is simple in operation and low in cost, the effective components of the folium ginkgo extracted by the method are seriously lost, the medicinal value of the folium ginkgo is greatly reduced, the extraction efficiency is low generally and is not suitable for large-scale production, and meanwhile, the extract with the solvent extraction method contains more impurities, the medicinal effect of the folium ginkgo extract is seriously influenced, and the quality of the folium ginkgo extract is influenced.
Therefore, in order to solve the above technical problems, it is necessary to provide a method for preparing ginkgo biloba extract.
Disclosure of Invention
The invention aims to provide a preparation method of a ginkgo leaf extract, which aims to solve the problems that the ginkgo leaf extract extracted by a solvent extraction method has serious loss of effective components and more impurities.
In order to achieve the above object, an embodiment of the present invention provides the following technical solutions:
a preparation method of a ginkgo leaf extract is characterized by comprising the following steps:
s1, taking 31-33 parts of ginkgo leaves according to parts by weight, taking 156-164 parts of ethanol solution with the concentration of 70-75% according to the weight volume ratio of kg/L, carrying out reflux extraction on the ginkgo leaves for 2-3 hours, and collecting an extracting solution; taking 124-132 parts of ethanol solution with the concentration of 70-75% to carry out reflux extraction on the ginkgo leaves for 1-2.5 hours again, and collecting extracting solution; then 156-164 parts of ethanol solution with the concentration of 70-75% is taken to carry out reflux extraction on the ginkgo leaves for 1-2 hours again, and extract liquid is collected;
s2, performing steaming recovery on ethanol in the ginkgo leaf residues until the concentration of the condensed ethanol liquid after steaming is lower than 20%, collecting steaming liquid, removing the leaf residues, combining the three extracting solutions and the steaming liquid, recovering the ethanol, and concentrating the extracting solution to an extract with the relative density of 1.15-1.20;
s3, heating the extract to dissolve in water, then circularly stirring for 30-120min by using cold water, maintaining the temperature of the cooling circulating water at 10-20 ℃, standing for 2-4 hours, separating supernatant to obtain water-precipitated clear liquid, and removing precipitates;
s4, eluting the water-precipitated clear liquid by soft water through a resin column, then resolving by using an ethanol solution with the concentration of 60-80%, deacidifying the resolved solution through a deacidification resin column, and collecting a deacidification solution;
s5, concentrating the deacidification solution to obtain an extract with the relative density of 1.15-1.20, drying the extract, and crushing the extract by a crusher to obtain ginkgo leaf extract dry extract powder.
Further, the pulverizer in S5 includes: the device comprises a crushing bin, an airflow type drying mechanism, a swinging type synergistic mechanism, a power type reverse mechanism and a torsion type collecting mechanism;
the lower side of the crushing bin is connected with a support frame, and the crushing bin is connected with a feeding and discharging pipe;
an airflow type drying mechanism is arranged in the crushing bin and is used for assisting in drying the traditional Chinese medicinal materials;
the airflow type drying mechanism comprises a pressure-dividing air bin, an electric heating wire is connected in the pressure-dividing air bin, and an air pump is connected to the crushing bin;
a swinging type synergistic mechanism is arranged in the crushing bin and used for increasing the contact area of the medicinal materials and the drying airflow;
the throwing type synergistic mechanism comprises a throwing disc, a plurality of convex ridges which are uniformly distributed are connected on the throwing disc, and an impact ring is connected in the crushing bin;
the crushing bin is connected with a power type reversing mechanism for improving the using effect of the swinging type synergistic mechanism;
one side of smashing the storehouse is equipped with torsional type and collects the mechanism for the collection of chinese-medicinal material.
Furthermore, a plurality of uniformly distributed vent holes are drilled in the partial pressure gas bin, so that gas in the partial pressure gas bin can enter the crushing bin more uniformly, and the airflow in the crushing bin is more stable;
the air pump runs through and smashes the storehouse setting, makes the air pump can inject the air into to partial pressure gas storehouse, makes the air in the partial pressure gas storehouse can obtain sufficient replenishment, the air pump is linked together with partial pressure gas storehouse.
Furthermore, a support ring is arranged in the crushing bin, so that the balance of the throwing disc is improved, the throwing disc can be supported, and the possibility of inclination of the throwing disc is effectively reduced;
when the throwing disc rotates, the balls can reduce the friction force between the throwing disc and the pressure dividing air bin and between the throwing disc and the support ring, so that the obstruction on the rotation of the throwing disc is effectively reduced, and the stability of the throwing disc is improved;
the support ring can support the support ring by being connected with between the support ring and the crushing storehouse, has promoted the stability of support ring, can also reduce the hindrance to the air current simultaneously, in addition, can also reduce the possibility that kibbling medicinal material falls into the bottom of crushing storehouse, has reduced the waste of medicinal material.
Furthermore, the power type reversing mechanism comprises a motor which can drive the electric shaft to rotate and provide corresponding power for the rotation of the electric shaft;
be connected with electronic axle on the motor, can rotate through the drive of motor to drive the rotation of smashing sword and positive bevel gear, electronic axle runs through and smashes the storehouse and gets rid of the dish setting.
Furthermore, a bearing is connected between the electric shaft and the throwing disc, so that the electric shaft is prevented from driving the throwing disc, and the friction force between the throwing disc and the electric shaft is reduced;
the last a plurality of crushing sword that are connected with of electronic axle can smash the medicinal material, makes the medicinal material can reach when smashing the purpose bigger area contact with the air current.
Furthermore, the electric shaft is connected with a forward bevel gear, and the reverse bevel gear can be driven to turn over through the transmission of the transmission bevel gear, so that the rotating directions of the throwing disc and the electric shaft are opposite, the medicinal material crushing effect is improved, the medicinal material can be better contacted with drying air flow, and the auxiliary drying effect on the medicinal material is effectively improved;
the throwing disc is connected with a reverse bevel gear, so that the driving of the transmission bevel gear is facilitated, the throwing disc can be driven to rotate synchronously, the transmission bevel gear is connected between the forward bevel gear and the reverse bevel gear, the transmission effect is achieved, and the rotation directions of the forward bevel gear and the reverse bevel gear are opposite.
Furthermore, the forward bevel gear and the reverse bevel gear are meshed with the transmission bevel gear, so that the accuracy among the forward bevel gear, the reverse bevel gear and the transmission bevel gear is improved, the installation part is connected between the transmission bevel gear and the crushing bin, the stability of the transmission bevel gear is improved, and the inclination probability of the transmission bevel gear is reduced.
Furthermore, the torsional collecting mechanism comprises a collecting pipe, and a user can sleeve the cloth bag on the collecting pipe, so that the medicinal materials can be conveniently collected;
a pair of collecting frames is connected between the collecting pipe and the supporting frame, so that the stability of the collecting pipe is improved, and the probability of inclination or separation of the collecting pipe is reduced;
the collecting pipe is connected with a collecting pipeline, and the position of the lifting pipeline can be adjusted through rotation, so that the lifting pipeline can be in butt joint with the feeding and discharging pipe or be far away from the feeding and discharging pipe.
Furthermore, one side of the collecting pipeline, which is close to the material inlet and outlet pipe, is connected with a lifting pipeline, the lifting pipeline can be lifted and butted with the material inlet and outlet pipe, when the lifting pipeline is butted with the material inlet and outlet pipe, medicinal materials can be collected, and when the lifting pipeline is not butted with the material inlet and outlet pipe, the material inlet and outlet pipe is used for feeding;
the lifting pipeline penetrates through the collecting pipeline, so that the lifting pipeline can be lifted;
the lifting pipeline is internally connected with the stretching frame, so that a user can conveniently control the position of the lifting pipeline, and the user can control the lifting of the lifting pipeline.
Further, the stretching frame runs through the collecting pipeline, a stretching spring is connected between the stretching frame and the collecting pipeline, the lifting pipeline can be extruded, the lifting pipeline is more tightly butted with the feeding and discharging pipe, and the possibility that the lifting pipeline is separated from the feeding and discharging pipe is reduced.
Compared with the prior art, the invention has the following advantages:
the invention reduces the loss of the effective components of the ginkgo leaf extract, greatly improves the medicinal value of the ginkgo leaf, improves the extraction speed, is more suitable for large-scale production, reduces the impurities in the extract, improves the medicinal effect of the ginkgo leaf extract and improves the quality of the ginkgo leaf extract by improving the ginkgo leaf extraction method.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the description of the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present invention, and it is also possible for those skilled in the art to obtain other drawings based on the drawings without creative efforts.
FIG. 1 is a sectional view of an embodiment of the present invention illustrating a method for preparing a ginkgo biloba extract;
FIG. 2 is a schematic view of the structure at A in FIG. 1;
FIG. 3 is a schematic view of the structure at B in FIG. 1;
FIG. 4 is a schematic view of the structure of FIG. 1 at C;
FIG. 5 is a schematic view of the structure of FIG. 1 at D;
fig. 6 is a perspective view of a method for preparing ginkgo biloba extract according to an embodiment of the present invention.
In the figure: 1. the device comprises a crushing bin, 101, a support frame, 102, a material inlet and outlet pipe, 2, an airflow type drying mechanism, 201, a partial pressure air bin, 202, an electric heating wire, 203, an air pump, 3, a swinging type efficiency-increasing mechanism, 301, a swinging disc, 302, a convex edge, 303, an impact ring, 304, a support ring, 305, a ball, 306, an anti-falling net, 4, a dynamic type reverse rotation mechanism, 401, an electric motor, 402, an electric shaft, 403, a bearing, 404, a crushing edge, 405, a forward bevel gear, 406, a reverse bevel gear, 407, a transmission bevel gear, 408, a mounting piece, 5, a torsional type collecting mechanism, 501, a collecting pipe, 502, a collecting frame, 503, a collecting pipe, 504, a lifting pipe, 505, a stretching frame, 506 and a stretching spring.
Detailed Description
The present invention will be described in detail below with reference to embodiments shown in the drawings. The embodiments are not intended to limit the present invention, and structural, methodological or functional changes made by those skilled in the art according to the embodiments are included in the scope of the present invention.
The invention discloses a preparation method of a ginkgo leaf extract, which is shown in figures 1-6 and comprises the following steps:
s1, taking 31-33 parts of ginkgo leaves according to parts by weight, taking 156-164 parts of ethanol solution with the concentration of 70-75% according to the weight volume ratio of kg/L, carrying out reflux extraction on the ginkgo leaves for 2-3 hours, and collecting an extracting solution; taking 124-132 parts of ethanol solution with the concentration of 70-75% to carry out reflux extraction on the ginkgo leaves for 1-2.5 hours again, and collecting extracting solution; then 156-164 parts of ethanol solution with the concentration of 70-75% is taken to carry out reflux extraction on the ginkgo leaves for 1-2 hours again, and extract liquid is collected;
s2, performing steaming recovery on ethanol in the ginkgo leaf residues until the concentration of the condensed ethanol liquid after steaming is lower than 20%, collecting steaming liquid, removing the leaf residues, combining the three extracting solutions and the steaming liquid, recovering the ethanol, and concentrating the extracting solution to an extract with the relative density of 1.15-1.20;
s3, heating and dissolving the extract in water, then circularly stirring for 30-120min by using cold water, maintaining the temperature of cooling circulating water at 10-20 ℃, standing for 2-4 hours, separating supernatant to obtain water-precipitated clear liquid, and removing precipitates;
s4, eluting the water-precipitated clear liquid by soft water through a resin column, then resolving by using an ethanol solution with the concentration of 60-80%, deacidifying the resolved solution through a deacidification resin column, and collecting a deacidification solution;
s5, concentrating the deacidification solution to obtain an extract with the relative density of 1.15-1.20, drying the extract, and crushing the extract by a crusher to obtain ginkgo leaf extract dry extract powder.
Referring to fig. 1 to 6, the pulverizer of S5 includes: the device comprises a crushing bin 1, an airflow type drying mechanism 2, a swinging type synergistic mechanism 3, a power type reverse mechanism 4 and a torsion type collecting mechanism 5.
Referring to fig. 1, the lower side of the crushing bin 1 is connected with a support frame 101, which facilitates the installation of the crushing bin 1, improves the stability of the crushing bin 1, and ensures the balance of the crushing bin 1.
Wherein, smash and be connected with into discharging pipe 102 on the storehouse 1, when with the butt joint of lift pipeline 504, as the ejection of compact that is used for the medicinal material, when not with the butt joint of lift pipeline 504, be used for the feeding of medicinal material.
Referring to fig. 1-4, an airflow drying mechanism 2 is disposed in the pulverizing bin 1 for assisting drying of the traditional Chinese medicinal materials, wherein the airflow drying mechanism 2 includes a partial pressure air bin 201, and can temporarily store air, so that the air can enter the pulverizing bin 1 more conveniently, and the heating wire 202 can be installed conveniently.
In addition, be connected with heating wire 202 in the partial pressure gas storehouse 201, can heat the air in the partial pressure gas storehouse 201, the effectual auxiliary action that has promoted the medicinal material stoving.
In addition, an air pump 203 is connected to the pulverizing chamber 1, and can pump the outside air, so that the air can enter the partial pressure chamber 201 to replenish the air in the partial pressure chamber 201 at any time.
Referring to fig. 1-4, a plurality of ventilation holes are uniformly distributed on the partial pressure gas bin 201, so that the gas in the partial pressure gas bin 201 can more uniformly enter the crushing bin 1, and the gas flow in the crushing bin 1 is more stable.
Wherein, the air pump 203 runs through crushing storehouse 1 setting, makes air pump 203 can inject the air into partial pressure gas storehouse 201, makes the air in the partial pressure gas storehouse 201 can obtain sufficient replenishment, and air pump 203 is linked together with partial pressure gas storehouse 201.
Referring to fig. 1-5, a swinging type synergistic mechanism 3 is arranged in the crushing bin 1 and used for increasing the contact area between the medicinal materials and the drying airflow, wherein the swinging type synergistic mechanism 3 comprises a swinging disc 301 and can bear the medicinal materials, so that the medicinal materials can rotate along with the swinging disc 301, and when the medicinal materials do not reach the crushing mesh number, the medicinal materials can slide to the bottom of the swinging disc 301 under the influence of gravity and are crushed by a crushing blade 404.
Wherein, when the weight of medicinal material is little to certain degree, can receive the whipping of flail dish 301, is thrown away protruding stupefied 302 and is strikeed with impingement ring 303, carries out further smashing, can contact with the stoving air current simultaneously, the effectual efficiency that has promoted supplementary stoving.
In addition, the swing disc 301 is connected with a plurality of uniformly distributed convex ridges 302, so that the medicinal materials on the swing disc 301 can vibrate, the friction force between the swing disc 301 and the medicinal materials is reduced, and the medicinal materials can be better influenced by gravity.
In addition, smash 1 in-connection of storehouse and have striking ring 303, can carry out striking each other with the medicinal material, make the crushing effect of medicinal material more ideal, the medicinal material can receive the support of air current simultaneously, gets into in the collecting duct 503 through inlet and outlet pipe 102.
Referring to fig. 1-4, the support ring 304 is disposed in the pulverizing bin 1, so that the balance of the flail disc 301 is improved, the flail disc 301 can be supported, and the possibility of inclination of the flail disc 301 is effectively reduced.
Wherein, the support ring 304 and partial pressure gas storehouse 201 all with get rid of and be connected with a plurality of balls 305 between the dish 301, when getting rid of the dish 301 and rotate to the time, the ball 305 can reduce the friction that gets rid of between dish 301 and partial pressure gas storehouse 201 and the support ring 304, the effectual hindrance that receives that has reduced and has got rid of the rotation of dish 301, promoted the stability of getting rid of dish 301.
In addition, support ring 304 and smash and be connected with between the storehouse 1 and prevent falling net 306, can support ring 304, promoted support ring 304's stability, can also reduce the hindrance to the air current simultaneously, in addition, can also reduce the possibility that kibbling medicinal material falls into and smashes storehouse 1 bottom, reduced the waste of medicinal material.
Referring to fig. 1-6, a power-driven reversing mechanism 4 is connected to the pulverizing bin 1 for improving the using effect of the swinging type synergistic mechanism 3, and the power-driven reversing mechanism 4 includes a motor 401 capable of driving the rotation of an electric shaft 402 to provide corresponding power for the rotation of the electric shaft 402.
Wherein, be connected with electronic axle 402 on the motor 401, can rotate through the drive of motor 401 to drive the rotation of smashing sword 404 and positive bevel gear 405, electronic axle 402 runs through and smashes storehouse 1 and throws the setting of dish 301.
Referring to fig. 1-6, a bearing 403 is connected between the electric shaft 402 and the flail disk 301, so as to avoid the electric shaft 402 from driving the flail disk 301, and reduce the friction between the flail disk 301 and the electric shaft 402.
In addition, be connected with a plurality of crushing sword 404 on the electronic axle 402, can smash the medicinal material, make the medicinal material can reach when smashing the purpose bigger area and air current contact.
Referring to fig. 1-5, the electric shaft 402 is connected with a spur bevel gear 405, and the transmission of the transmission bevel gear 407 can drive a reverse bevel gear 406 to overturn, so that the rotation direction of the swing disc 301 is opposite to that of the electric shaft 402, thereby not only improving the effect of crushing the medicinal material, but also enabling the medicinal material to better contact with the drying airflow, and effectively improving the auxiliary drying effect on the medicinal material.
In other words, the reverse bevel gear 406 is connected to the swing disc 301, so that the driving of the transmission bevel gear 407 is facilitated, the swing disc 301 can be driven to rotate synchronously, the transmission bevel gear 407 is connected between the forward bevel gear 405 and the reverse bevel gear 406, the transmission effect is achieved, and the rotation directions of the forward bevel gear 405 and the reverse bevel gear 406 are opposite.
Referring to fig. 1-5, the bevel spur gear 405 and the bevel reverse gear 406 are engaged with the bevel drive gear 407, so that the accuracy among the bevel spur gear 405, the bevel reverse gear 406 and the bevel drive gear 407 is improved, and the mounting member 408 is connected between the bevel drive gear 407 and the crushing bin 1, so that the stability of the bevel drive gear 407 is improved, and the probability of the bevel drive gear 407 tilting is reduced.
Referring to fig. 1-5, one side of smashing storehouse 1 is equipped with torsion type and collects mechanism 5 for the collection of chinese-medicinal material, and torsion type collection mechanism 5 includes collecting pipe 501, and the user can make things convenient for the collection of chinese-medicinal material with the sack cover on collecting pipe 501.
Wherein, a pair of collecting frames 502 is connected between the collecting pipe 501 and the supporting frame 101, which improves the stability of the collecting pipe 501 and reduces the probability of inclination or separation of the collecting pipe 501.
Preferably, the collecting pipe 501 is connected with a collecting pipe 503, and the position of the lifting pipe 504 can be adjusted by rotation, so that the lifting pipe 504 can be butted with the feeding and discharging pipe 102 or be far away from the feeding and discharging pipe 102.
Referring to fig. 1-6, a lifting pipe 504 is connected to a side of the collecting pipe 503 close to the inlet/outlet pipe 102, and can lift and butt with the inlet/outlet pipe 102, when the lifting pipe 504 is butt-jointed with the inlet/outlet pipe 102, the medicinal material can be collected, and when the lifting pipe 504 is not butt-jointed with the inlet/outlet pipe 102, the inlet/outlet pipe 102 is used for feeding.
The elevating duct 504 is provided to penetrate the collecting duct 503 so that the elevating duct 504 can be elevated.
Optionally, a stretching frame 505 is connected in the lifting pipe 504, so that a user can conveniently control the position of the lifting pipe 504, and the user can control the lifting of the lifting pipe 504.
Referring to fig. 1 to 6, the stretching frame 505 penetrates through the collecting pipe 503, and the stretching spring 506 is connected between the stretching frame 505 and the collecting pipe 503, so that the lifting pipe 504 can be squeezed, the lifting pipe 504 can be more tightly butted with the feeding and discharging pipe 102, and the possibility that the lifting pipe 504 is separated from the feeding and discharging pipe 102 is reduced.
Specifically, the user puts into the medicinal material through inlet outlet pipe 102 and smashes storehouse 1 in, opens motor 401, makes electronic axle 402 drive smash the sword 404 rotatory, and is synchronous, through transmission bevel gear 407, makes disc 301 and electronic axle 402 counter-rotation get rid of, and disc 301, impact ring 303 and the mesh of smashing the effect of having played the promotion this moment and having smashed the sword 404, can strengthen the efficiency that the drug effect was dried.
At this moment, when the medicinal material does not reach crushing mesh number, can receive the influence of gravity and slide to getting rid of a set 301 bottom, receive the crushing of smashing sword 404, when the weight of medicinal material is little to certain degree, can receive the whipping of getting rid of a set 301, it strikes with impingement ring 303 to be thrown out protruding stupefied 302, carry out further crushing, can contact with the stoving air current simultaneously, the effectual efficiency of supplementary stoving that has promoted, medicinal material after the completion of smashing gets into collecting pipe 501 through collecting pipe 503 in, collect through the sack.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the specification has been described in terms of embodiments, not every embodiment includes every single embodiment, and such description is for clarity purposes only, and it will be appreciated by those skilled in the art that the specification as a whole can be combined as appropriate to form other embodiments as will be apparent to those skilled in the art.
Claims (10)
1. The preparation method of the ginkgo leaf extract is characterized by comprising the following steps:
s1, taking 31-33 parts of ginkgo leaves according to parts by weight, taking 156-164 parts of ethanol solution with the concentration of 70-75% according to kg/L weight volume ratio, carrying out reflux extraction on the ginkgo leaves for 2-3 hours, and collecting an extracting solution; taking 124-132 parts of ethanol solution with the concentration of 70-75% to carry out reflux extraction on the ginkgo leaves for 1-2.5 hours again, and collecting extracting solution; then 156-164 parts of ethanol solution with the concentration of 70-75% is taken to carry out reflux extraction on the ginkgo leaves for 1-2 hours again, and extract liquid is collected;
s2, performing steaming recovery on ethanol in the ginkgo leaf residues until the concentration of the condensed ethanol liquid after steaming is lower than 20%, collecting steaming liquid, removing the leaf residues, combining the three extracting solutions and the steaming liquid, recovering the ethanol, and concentrating the extracting solution to an extract with the relative density of 1.15-1.20;
s3, heating the extract to dissolve in water, then circularly stirring for 30-120min by using cold water, maintaining the temperature of the cooling circulating water at 10-20 ℃, standing for 2-4 hours, separating supernatant to obtain water-precipitated clear liquid, and removing precipitates;
s4, eluting the water-precipitated clear liquid by soft water through a resin column, then resolving by using an ethanol solution with the concentration of 60-80%, deacidifying the resolved solution through a deacidification resin column, and collecting a deacidification solution;
s5, concentrating the deacidification solution to obtain an extract with the relative density of 1.15-1.20, drying the extract, and crushing the extract by a crusher to obtain ginkgo leaf extract dry extract powder.
2. The method of claim 1, wherein the pulverizer of S5 comprises:
the device comprises a crushing bin (1), wherein a support frame (101) is connected to the lower side of the crushing bin (1), and a feeding and discharging pipe (102) is connected to the crushing bin (1);
the airflow type drying mechanism (2) is arranged in the crushing bin (1) and is used for assisting in drying the traditional Chinese medicinal materials;
the airflow type drying mechanism (2) comprises a pressure dividing air bin (201), an electric heating wire (202) is connected in the pressure dividing air bin (201), and an air pump (203) is connected to the crushing bin (1);
the swinging type synergistic mechanism (3) is arranged in the crushing bin (1) and is used for increasing the contact area of the medicinal materials and the drying airflow;
the swinging type synergistic mechanism (3) comprises a swinging disc (301), a plurality of uniformly distributed convex ridges (302) are connected to the swinging disc (301), and an impact ring (303) is connected to the crushing bin (1);
the power type reversing mechanism (4) is connected to the crushing bin (1) and is used for improving the using effect of the swinging type synergistic mechanism (3);
the torsional type collecting mechanism (5) is arranged on one side of the crushing bin (1) and is used for collecting the traditional Chinese medicines.
3. The method for preparing ginkgo biloba extract according to claim 1, wherein the partial pressure air chamber (201) is provided with a plurality of uniformly distributed ventilation holes, the air pump (203) is disposed through the pulverizing chamber (1), and the air pump (203) is communicated with the partial pressure air chamber (201).
4. The method for preparing ginkgo biloba extract according to claim 1, wherein a support ring (304) is arranged in the pulverizing bin (1), a plurality of balls (305) are connected between the support ring (304) and the throwing disk (301) and between the pressure dividing air bin (201) and the support ring (304), and an anti-dropping net (306) is connected between the support ring (304) and the pulverizing bin (1).
5. The method for preparing ginkgo biloba extract according to claim 1, wherein the powered reversing mechanism (4) comprises an electric motor (401), the electric motor (401) is connected with an electric shaft (402), the electric shaft (402) is arranged to penetrate through the pulverizing bin (1) and the throwing disk (301), a bearing (403) is connected between the electric shaft (402) and the throwing disk (301), and a plurality of pulverizing blades (404) are connected to the electric shaft (402).
6. The method for preparing ginkgo biloba extract according to claim 5, wherein a forward bevel gear (405) is connected to the electric shaft (402), a reverse bevel gear (406) is connected to the swing disc (301), and a transmission bevel gear (407) is connected between the forward bevel gear (405) and the reverse bevel gear (406).
7. The method for preparing ginkgo biloba extract according to claim 6, wherein the forward bevel gear (405) and the reverse bevel gear (406) are engaged with a transmission bevel gear (407), and a mounting member (408) is connected between the transmission bevel gear (407) and the pulverizing bin (1).
8. The method for preparing ginkgo biloba extract according to claim 1, wherein the twisting type collection mechanism (5) comprises a collection pipe (501), a pair of collection racks (502) is connected between the collection pipe (501) and the support frame (101), and a collection pipeline (503) is connected to the collection pipe (501).
9. The method for preparing ginkgo biloba extract according to claim 8, wherein a lifting pipe (504) is connected to one side of the collecting pipe (503) close to the feeding and discharging pipe (102), the lifting pipe (504) is disposed through the collecting pipe (503), and a stretching frame (505) is connected to the lifting pipe (504).
10. The method for preparing ginkgo biloba extract according to claim 9, wherein the stretching frame (505) is disposed through the collection pipe (503), and a stretching spring (506) is connected between the stretching frame (505) and the collection pipe (503).
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US5322688A (en) * | 1989-12-04 | 1994-06-21 | Dr. Willmar Schwabe Gmbh & Co. | Method of preparation of an extract from Ginkgo biloba leaves and pharmaceuticals containing the extract |
DE102017204379A1 (en) * | 2016-03-16 | 2017-09-21 | Zhejiang Xinchang Natural Health Products Co., Ltd. | Preparation process of a water-soluble ginko leaf extract and water-soluble ginko leaf extract |
CN107753529A (en) * | 2017-11-09 | 2018-03-06 | 重庆科瑞南海制药有限责任公司 | A kind of preparation method of ginkgo biloba p.e |
CN109045076A (en) * | 2018-10-24 | 2018-12-21 | 江苏金纳多生物科技有限公司 | A kind of preparation method of ginkgo biloba p.e |
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2022
- 2022-08-24 CN CN202211020593.9A patent/CN115154492A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US5322688A (en) * | 1989-12-04 | 1994-06-21 | Dr. Willmar Schwabe Gmbh & Co. | Method of preparation of an extract from Ginkgo biloba leaves and pharmaceuticals containing the extract |
DE102017204379A1 (en) * | 2016-03-16 | 2017-09-21 | Zhejiang Xinchang Natural Health Products Co., Ltd. | Preparation process of a water-soluble ginko leaf extract and water-soluble ginko leaf extract |
CN107753529A (en) * | 2017-11-09 | 2018-03-06 | 重庆科瑞南海制药有限责任公司 | A kind of preparation method of ginkgo biloba p.e |
CN109045076A (en) * | 2018-10-24 | 2018-12-21 | 江苏金纳多生物科技有限公司 | A kind of preparation method of ginkgo biloba p.e |
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