CN115120788B - Medical hydrophilic coating solution and coating method thereof - Google Patents
Medical hydrophilic coating solution and coating method thereof Download PDFInfo
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- CN115120788B CN115120788B CN202210533409.4A CN202210533409A CN115120788B CN 115120788 B CN115120788 B CN 115120788B CN 202210533409 A CN202210533409 A CN 202210533409A CN 115120788 B CN115120788 B CN 115120788B
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/04—Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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Abstract
The application relates to the technical field of hydrophilic coatings, in particular to a medical hydrophilic coating solution and a coating method thereof. The medical hydrophilic coating solution consists of a primer composition and a top-coat composition; the primer composition comprises the following components in parts by weight: 10-25 parts of aqueous bonding base material, 0.2-0.3 part of first photoinitiator, 2-5 parts of cross-linking agent and 75-95 parts of first solvent; the finishing paint composition comprises the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 0-2 parts of silane coupling agent, 0-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent. The application ensures the lubricating and wetting effects of the paint through the compound use of the primer composition and the face paint composition, and simultaneously remarkably improves the adhesive force of the paint, and is not easy to peel off from the ox horn expander.
Description
Technical Field
The application relates to the technical field of hydrophilic coatings, in particular to a medical hydrophilic coating solution and a coating method thereof.
Background
The medical hydrophilic coating is a technology for modifying the surface of a medical instrument, meets the medical standard requirement, has good biocompatibility, and is special for modifying the surface of a ox horn expander because the medical hydrophilic coating can reduce the friction between the medical instrument and a human body, is beneficial to reducing the operation difficulty of doctors, reduces the pain of patients and the like.
The medical hydrophilic coating solution in the related art discloses a hydrophilic coating solution containing hydrophilic high molecular polymers such as polyvinylpyrrolidone, polyalcohol and the like, has good toughness in a dry state, can be uniformly adhered on the surface of a ox horn expander, is colorless and transparent, and is not easy to observe by naked eyes;
in the wet state, the coating can be rapidly activated and hydrated by water and forms a colorless transparent hydrogel which is highly lubricious and can withstand repeated rubbing, thereby imparting excellent lubricity and wettability to the surface of the bullhorn dilator.
The medical hydrophilic coating solution can meet the basic application requirements of people, has excellent lubrication and wetting properties, but has poor general cohesiveness and adhesive force, and the cured coating is easy to peel off under the action of internal stress or external force, so that the lubrication and wetting effects are greatly reduced.
Disclosure of Invention
In order to ensure the lubricating and wetting effects of the coating and improve the adhesive force of the coating so that the coating is not easy to peel off, the application provides a medical hydrophilic coating solution and a coating method thereof.
In a first aspect, the present application provides a medical hydrophilic coating solution, which adopts the following technical scheme:
a medical hydrophilic coating solution consists of a primer composition and a face paint composition;
the primer composition comprises the following components in parts by weight: 10-25 parts of aqueous bonding base material, 0.2-0.3 part of first photoinitiator, 2-5 parts of cross-linking agent and 75-95 parts of first solvent;
the aqueous bonding base material is prepared by blending and modifying saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide;
the finishing paint composition comprises the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 0-2 parts of silane coupling agent, 0-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent.
By adopting the technical scheme, the medical hydrophilic coating solution obtained by mixing the primer composition and the finish composition is stable in coating structure formed by curing the primer composition and the finish composition, and high performance can be kept for a long time, and the adhesion of the medical hydrophilic coating solution is improved through the primer composition after the medical hydrophilic coating solution is respectively coated on the surface of the ox horn dilator, so that the coating structure is not easy to fall off, and meanwhile, the excellent lubricating and wetting effects can be given to the coating composition through the finish composition.
The reasons for this analysis may be:
the water-based adhesive base material is formed by blending saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide, the components have a synergistic effect, a compact composite reticular structure can be formed by bonding double bonds and polar groups, the reticular structure is stacked layer by layer and crosslinked with each other, the viscosity and the adhesion performance of the coating are obviously enhanced, and in addition, the composite reticular structure can be further crosslinked with hydrophilic polyurethane under the action of a crosslinking agent, so that the combination property and the stability of a primer composition and a finish composition are enhanced.
Preferably, the ratio of the saturated polyester resin to the unsaturated acrylic resin to the polyamide wax to the polyamide imide is 1 (0.8-1.5) (0.2-0.3) (0.3-0.5).
By adopting the technical scheme, the water-based adhesive base material formed by blending the saturated polyester resin, the unsaturated acrylic resin, the polyamide wax and the polyamide imide according to the proportion has better synergistic effect among the components, and the crosslinked composite reticular structure is more compact and complex, so that the primer composition has excellent viscosity and adhesion performance.
Preferably, the first photoinitiator and the second photoinitiator are respectively selected from one or more of 1-hydroxycyclohexyl phenyl ketone, diphenyl ketone and 2, 4-dihydroxybenzophenone.
By adopting the technical scheme, the photoinitiator with the components and the proportion can effectively absorb the wavelength in the ultraviolet region and generate a large amount of free radicals and cations, so that the crosslinking and curing of the primer composition and the top-coat composition are promoted.
Preferably, the cross-linking agent is one or more of ethylene glycol dimethacrylate, polyethylene glycol diacrylate and 1, 4-butanediol diacrylate.
By adopting the technical scheme, the cross-linking agent with the components and the proportion can effectively provide double free radicals and active groups, and form a bridge bond with a polymer molecular chain and a double bond, thereby being beneficial to forming a compact and complex three-dimensional cross-linked network structure.
Preferably, the first solvent is one or more of ethanol, glycerol and ethyl acetate; the second solvent consists of two or more of ethanol, isopropanol, ethyl acetate and water.
Preferably, the primer composition comprises the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 1-2 parts of silane coupling agent, 2-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent.
By adopting the technical scheme, the finishing paint composition with the components and the proportion can further enhance the mechanical property under the action of nano silicon dioxide and a silane coupling agent, and can obviously reduce the surface energy of the surface of a coating after being compounded with hydrophilic polyurethane and polyvinylpyrrolidone, thereby achieving better lubrication and wetting effects.
In a second aspect, the present application provides a method for coating a medical hydrophilic coating solution, which adopts the following technical scheme: a coating method of medical hydrophilic coating solution comprises the following coating steps:
s1, firstly, soaking a ox horn expander to be coated in a primer composition, and after the primer composition finishes coating, lifting the ox horn expander to be coated and carrying out irradiation curing at the next stage of an ultraviolet lamp to obtain the ox horn expander coated with the bottom layer;
s2, soaking the ox horn expander coated with the bottom layer in the finishing paint composition, and after finishing coating of the finishing paint composition, lifting the ox horn expander coated with the bottom layer and carrying out secondary irradiation curing under an ultraviolet lamp to obtain the ox horn expander coated with the hydrophilic coating.
Preferably, the specific coating steps are as follows:
s1, firstly soaking a ox horn expander to be coated in a primer composition for 30-60S, after the primer composition finishes coating, extracting the ox horn expander to be coated at a constant speed of 0.5-1.0cm/S, and carrying out irradiation curing at the next stage of a 1200W ultraviolet lamp for 60-90S to obtain the ox horn expander coated with the bottom layer;
s2, soaking the ox horn expander coated with the bottom layer in the finishing paint composition for 20-30S, after finishing coating of the finishing paint composition, extracting the ox horn expander coated with the bottom layer at a constant speed of 0.5-1.0cm/S, and performing secondary irradiation curing for 90-180S under a 600W ultraviolet lamp to finish coating, thereby obtaining the ox horn expander coated with the hydrophilic coating.
By adopting the technical scheme, the medical hydrophilic coating solution sequentially coated on the surface of the ox horn expander by the coating method can improve the integral adhesive force of the ox horn expander while guaranteeing the lubricating and wetting effects of the surface, the operation condition is easy to control, the energy consumption is lower, and the obtained product has stable and uniform performance and is suitable for industrialized processing and production.
In summary, the present application has the following beneficial effects:
1. the adhesive force of the primer composition and the surface paint composition is improved, the coating structure is not easy to fall off, the surface of the primer composition and the surface paint composition have excellent lubricating and wetting effects, the compatibility of the primer composition and the surface paint composition is good, the coating structure formed by curing the primer composition and the surface paint composition is stable, and the high performance can be kept for a long time;
2. according to the preparation method, the nano silicon dioxide and the silane coupling agent are doped, so that the mechanical property of the coating structure is enhanced, and the surface energy of the surface of the coating can be obviously reduced after the coating is compounded with hydrophilic polyurethane and polyvinylpyrrolidone, so that better lubricating and wetting effects are achieved;
3. according to the medical hydrophilic coating solution sequentially coated on the surface of the ox horn expander by the coating method, the whole adhesive force of the coating structure can be improved while the lubricating and wetting effects of the surface are ensured, and the energy consumption is low, so that the method is suitable for industrialized processing and production.
Detailed Description
The present application is described in further detail below with reference to examples.
The raw materials used in the examples of the present application are commercially available except for the following specific descriptions:
hydrophilic polyurethane, brand WanSponeFPT, purchased from Suzhou Yuan Tai wetting chemical Co., ltd;
polyvinylpyrrolidone, CAS registry number 9003-39-8;
saturated polyester resin, brand polyester resin 930, model CW-Zn-002, purchased from Shanghai Kaiyin chemical Co., ltd;
polyamide wax, brand DuPont, purchased from kappyinfi chemical company, shanghai;
polyamide imide, trade name 4301, purchased from Hongshou Limited in Dongguan City;
unsaturated acrylic resin, model ALK150-2, purchased from Yuxuan, inc. of Dongguan;
polyethylene glycol diacrylate, CAS 26570-48-9;
silane coupling agent, model KH-550, dewar/DOUWAR, available from Dewar chemical industry (Shanghai) Co., ltd;
the nano silicon dioxide has an average particle diameter of 20nm and a specific surface area of 200m2/g, and is purchased from Nanjing Baoket New Material Co.
Preparation example
Preparation example 1
A medical hydrophilic coating solution consists of a primer composition and a top-coat composition, wherein the components and parts by weight of the primer composition and the top-coat composition are shown in table 1;
wherein the water-based bonding base material consists of saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide according to the weight ratio of 1:0.5:0.1:0.2;
the first photoinitiator and the second photoinitiator are 1-hydroxycyclohexyl phenyl ketone;
the cross-linking agent is ethylene glycol dimethacrylate;
the silane coupling agent is KH-550;
the first solvent is ethanol; the second solvent consists of ethanol and ethyl acetate according to the weight ratio of 1:0.5.
The medical hydrophilic coating solution is prepared by the following preparation steps: mixing the components in the primer composition and the face paint composition for 30min at 2500r/min respectively, and stirring the components into uniform slurry to obtain the medical hydrophilic coating solution.
Preparation examples 2 to 6
A medical hydrophilic coating solution is different from that of preparation example 1 in that the components of the aqueous binder base stock and their respective weights are shown in Table 1.
TABLE 1 preparation examples 1-6 hydrophilic coating solutions for TCM each component and weight (kg)
Preparation example 7
The medical hydrophilic coating solution is the same as in preparation example 1 except that the water-based adhesive base material consists of saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide according to the weight ratio of 1:0.8:0.2:0.3.
Preparation example 8
The medical hydrophilic coating solution is the same as in preparation example 1 except that the water-based adhesive base material consists of saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide according to the weight ratio of 1:1.2:0.2:0.4.
Preparation example 9
The medical hydrophilic coating solution is the same as in preparation example 1 except that the water-based adhesive base material consists of saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide according to the weight ratio of 1:1.5:0.3:0.5.
Preparation example 10
The medical hydrophilic coating solution is the same as in preparation example 1 except that the water-repellent adhesive base material consists of saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide according to the weight ratio of 1:2:0.5:1.
PREPARATION EXAMPLE 11
A medical hydrophilic coating solution was prepared in the same manner as in preparation example 1 except that the first photoinitiator and the second photoinitiator were diphenylethanone.
Preparation example 12
A medical hydrophilic coating solution was prepared in the same manner as in preparation example 1 except that the first photoinitiator was 1-hydroxycyclohexyl phenyl ketone and the second photoinitiator was diphenylethanone.
Preparation example 13
A medical hydrophilic coating solution is prepared from 1-hydroxycyclohexyl phenyl ketone and 2, 4-dihydroxybenzophenone in a weight ratio of 1:0.3 as a first photoinitiator, and diphenylethanone as a second photoinitiator, wherein the first photoinitiator is the same as that of preparation example 1.
PREPARATION EXAMPLE 14
A medical hydrophilic coating solution is the same as in preparation example 1 except that the crosslinking agent is polyethylene glycol diacrylate.
Preparation example 15
A medical hydrophilic coating solution was prepared in the same manner as in preparation example 1 except that the crosslinking agent was 1, 4-butanediol diacrylate.
PREPARATION EXAMPLE 16
A medical hydrophilic coating solution is the same as in preparation example 1 except that the crosslinking agent consists of ethylene glycol dimethacrylate and 1, 4-butanediol diacrylate in a weight ratio of 1:2.
Preparation example 17
A medical hydrophilic coating solution except that the first solvent is ethyl acetate; the second solvent was the same as in preparation example 1 except that it consisted of ethanol and water in a weight ratio of 1:0.1.
PREPARATION EXAMPLE 18
A medical hydrophilic coating solution was the same as in preparation example 1 except that the first solvent and the second solvent were both composed of ethanol and ethyl acetate in a weight ratio of 1:0.3.
Performance test
The ox horn dilators coated with the medical hydrophilic coating in examples and comparative examples were selected as detection objects, and the adhesion and the hydrophilic wettability of each group were respectively tested, and the detection steps were as follows, and reference may be made to GB-T5210-2006 "paint and varnish pull-off adhesion test" and DB 44/T1232-2013 "test method contact angle method for measuring surface tension of solid coating, substrate and pigment".
1) Adhesion detection
According to the specification of GB/T5210-2006, a test column with the diameter of 20mm is adopted, an upper test column and a lower test column are in coaxial butt joint with a test plate for testing, three groups of medical hydrophilic coating solutions are arranged in parallel in each group, and the average value of test results is recorded.
2) Hydrophilic wettability (coating contact angle)
And detecting according to the rule of DB 44/T1232-2013, wherein three groups are arranged in parallel in each group, after pure water is dripped on the surface of the ox horn expander, recording the three-phase contact points of liquid, solid and gas and the internal included angle between a base line and a tangent line, taking an average value and recording the average value as a coating contact angle, and representing the hydrophilic wetting property of the coating.
Examples
Example 1
A method for coating a medical hydrophilic coating solution using the medical hydrophilic coating solution prepared in preparation example 1, comprising the following coating steps:
s1, soaking a ox horn expander to be coated in a primer composition for 30S, after the primer composition finishes coating, lifting the ox horn expander to be coated at a constant speed of 1.0cm/S, and carrying out irradiation curing at the next stage of a 1200W ultraviolet lamp for 60S to obtain the ox horn expander coated with the bottom layer;
s2, soaking the ox horn expander coated with the bottom layer in the finish paint composition for 20S, after the finish paint composition finishes coating, lifting the ox horn expander coated with the bottom layer at a constant speed of 1.0cm/S, and carrying out secondary irradiation curing for 90S under a 600W ultraviolet lamp to finish coating, thereby obtaining the ox horn expander coated with the hydrophilic coating.
Examples 2 to 6
A method for coating a medical hydrophilic coating solution is different from example 1 in that the medical hydrophilic coating solution used is different in use condition, and specific correspondence is shown in the following table.
Table: examples 2-6 comparative tables of use of hydrophilic coating solutions in medicine
| Group of | Medical hydrophilic coating solution |
| Example 2 | Prepared from preparation example 2 |
| Example 3 | Prepared from preparation example 3 |
| Example 4 | Prepared from preparation 4 |
| Example 5 | Prepared from preparation 5 |
| Example 6 | From preparation 6 |
Comparative example 1
The coating method of the medical hydrophilic coating solution is different from the coating method of the embodiment 1 in that the medical hydrophilic coating solution comprises the following components in parts by weight: 8 parts of waterborne polyurethane, 5 parts of polyvinylpyrrolidone, 0.1 part of photoinitiator and 90 parts of solvent;
wherein the photoinitiator is 1-hydroxycyclohexyl phenyl ketone, and the solvent is ethanol and ethyl acetate according to the weight ratio of 1:0.5.
The ox horn dilators coated with the medical hydrophilic coating solution of examples 1-6 and comparative example 1 were withdrawn, tested for adhesion, hydrophilic wettability according to the above-described measurement procedure and measurement criteria, and the average value of the test results was recorded in the following table.
As can be seen from the table, the adhesive force of the medical hydrophilic coating solution prepared in the examples 1-6 is stronger and is as high as 5.6-6.6MPa, and compared with the traditional Chinese medicine hydrophilic coating solution in the comparative example 1, the adhesive force is improved by 33-55%; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 3-5 degrees;
the medical hydrophilic coating solution with the components can improve the adhesive force of the coating solution through the primer composition after being coated on the surface of the ox horn expander, can endow the surface of the ox horn expander with excellent lubrication and wetting effects through the finish composition, has good compatibility between the primer composition and the finish composition, has a stable coating structure formed by curing the primer composition and the finish composition, and can keep high performance for a long time.
In particular, the medical hydrophilic coating solution prepared in examples 3-4 has strong adhesive force, which is as high as 6.5-6.6MPa; and the contact angle of the coating is only 3 degrees, which is reduced by 2 degrees compared with the example 1-2 without adding the nano silicon dioxide and the silane coupling agent;
it can be seen that the composition and the ratio of the medical hydrophilic coating solution have the optimal compounding effect, and when the dosage of the aqueous adhesive base material or the cross-linking agent is continuously increased, the performance of the coating is not increased as expected, and the analysis of the reason is probably due to the fact that the cross-linking state among the components tends to be saturated, see application examples 5-6.
In summary, the reason for this is probably due to the synergistic effect of the components of the aqueous binder, a dense composite network structure can be formed by bonding of double bonds and polar groups, and the network structures are stacked layer by layer and crosslinked with each other, so that the viscosity and adhesion properties of the coating are remarkably enhanced, and in addition, the composite network structure can further undergo a crosslinking reaction with hydrophilic polyurethane under the action of a crosslinking agent, so that the bonding property and stability of the primer composition and the top coating composition are enhanced.
Examples 7 to 10
A method for coating a medical hydrophilic coating solution is different from example 1 in that the medical hydrophilic coating solution used is different in use condition, and specific correspondence is shown in the following table.
Table: examples 7-10 comparative tables of use of hydrophilic coating solutions in medicine
| Group of | Medical hydrophilic coating solution |
| Example 7 | Prepared from preparation 7 |
| Example 8 | Prepared from preparation 8 |
| Example 9 | Prepared in preparation example 9 |
| Example 10 | Prepared from preparation 10 |
Comparative example 2
A coating method of medical hydrophilic coating solution is different from example 1 in that the aqueous adhesive base material consists of saturated polyester resin and unsaturated acrylic resin according to the weight ratio of 1:1.5.
Comparative example 3
A coating method of medical hydrophilic coating solution is different from example 1 in that the aqueous adhesive base material consists of unsaturated acrylic resin, polyamide wax and polyamide imide according to the weight ratio of 1:0.2:0.3.
The ox horn dilators coated with the medical hydrophilic coating solutions of examples 7-10 and comparative examples 2-3 were extracted, and the adhesion, hydrophilic wettability, and the average value of the test results were measured according to the above-mentioned measurement procedure and measurement standard, and are shown in the following table.
As can be seen from the table, the medical hydrophilic coating solutions prepared in the examples 1 and 7-10 have stronger adhesive force, which is up to 5.6-6.5MPa, and is improved by 17-22% compared with the comparative examples 2-3; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 5 degrees;
the water-based adhesive base material formed by blending the saturated polyester resin, the unsaturated acrylic resin, the polyamide wax and the polyamide imide according to the proportion has better synergistic effect among the components, and the crosslinked and formed composite net structure is more compact and complex, so that the primer composition is endowed with excellent viscosity and adhesion performance, and the adhesion performance is reduced after a certain component is absent, see comparative examples 2-3.
In particular, the medical hydrophilic coating solutions prepared in examples 7-9 have strong adhesion, up to 6.3-6.5MPa; the coating contact angle is only 5 degrees, and the visible water-based adhesive base material has better compounding effect when the coating contact angle is composed of saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide according to the dosage ratio of 1 (0.8-1.5) (0.2-0.3) (0.3-0.5).
Examples 11 to 13
A method for coating a medical hydrophilic coating solution is different from example 1 in that the medical hydrophilic coating solution used is different in use condition, and specific correspondence is shown in the following table.
Table: examples 11-13 comparative Table of use of hydrophilic coating solutions in medicine
| Group of | Medical hydrophilic coating solution |
| Example 11 | Prepared from preparation 11 |
| Example 12 | From preparation 12 |
| Example 13 | Prepared in preparation example 13 |
The ox horn dilators coated with the medical hydrophilic coating solutions of examples 11-13 above were extracted, and the adhesion, hydrophilic wettability, and the average value of the results of the measurements were measured according to the above-mentioned measurement procedures and measurement criteria and are shown in the following table.
As can be seen from the above table, the medical hydrophilic coating solutions prepared in examples 1 and 11-13 have strong adhesive force, which is as high as 5.5-5.8MPa; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 5 degrees;
the photoinitiator with the components and the proportion can effectively absorb the wavelength of ultraviolet light region and generate a large amount of free radicals and cations, so that the crosslinking and curing of the primer composition and the face paint composition are promoted, the influence on the actual wetting property and the adhesive force performance of the paint is weak, and the adhesive force is only slightly improved when the paint is compounded and used.
Examples 14 to 16
A method for coating a medical hydrophilic coating solution is different from example 1 in that the medical hydrophilic coating solution used is different in use condition, and specific correspondence is shown in the following table.
Table: examples 14-16 comparative tables of use of hydrophilic coating solutions in medicine
| Group of | Medical hydrophilic coating solution |
| Example 14 | From preparation 14 |
| Example 15 | Prepared in preparation 15 |
| Example 16 | From preparation 16 |
The ox horn dilators coated with the medical hydrophilic coating solution of examples 14-16 above were extracted, tested for adhesion, hydrophilic wettability, and the average of the test results was recorded in the following table, according to the above-described measurement procedure and measurement criteria.
As can be seen from the above table, the medical hydrophilic coating solutions prepared in examples 1 and 14-16 have strong adhesive force, which is as high as 5.5-6.0MPa; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 5 degrees;
the components and the proportion of the cross-linking agent can effectively provide double free radicals and active groups, form a bridge bond with a polymer molecular chain and a double bond, are favorable for forming a compact and complex three-dimensional cross-linked network structure, have influence on the actual adhesive force performance and viscosity of the coating, and can improve the adhesive force by 7-9% when the cross-linking agent is compounded and used by ethylene glycol dimethacrylate and 1, 4-butanediol diacrylate.
Examples 17 to 18
A method for coating a medical hydrophilic coating solution is different from example 1 in that the medical hydrophilic coating solution used is different in use condition, and specific correspondence is shown in the following table.
Table: examples 17-18 comparison Table of use of the hydrophilic coating solution in the medical science
| Group of | Medical hydrophilic coating solution |
| Example 17 | Prepared in preparation example 17 |
| Example 18 | From preparation 18 |
The ox horn dilators coated with the medical hydrophilic coating solution of examples 17-18 above were extracted, tested for adhesion, hydrophilic wettability according to the above measurement procedure and measurement criteria, and the average value of the test results was recorded in the following table.
As can be seen from the above table, the medical hydrophilic coating solutions prepared in examples 1 and 17-18 have strong adhesive force, which is as high as 5.6-5.7MPa; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 5 degrees;
the components and the solvent in the proportion can effectively ensure the compounding effect of the components, the selection of the components and the compounding have no influence on the performance of the coating basically, and the cost regulation and the quality control are convenient while the actual production is facilitated.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (8)
1. A medical hydrophilic coating solution, which is characterized by consisting of a primer composition and a top-coat composition;
the primer composition comprises the following components in parts by weight: 10-25 parts of aqueous bonding base material, 0.2-0.3 part of first photoinitiator, 2-5 parts of cross-linking agent and 75-95 parts of first solvent;
the aqueous bonding base material is prepared by blending and modifying saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide;
the finishing paint composition comprises the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 0-2 parts of silane coupling agent, 0-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent.
2. The medical hydrophilic coating solution according to claim 1, wherein the ratio of the amounts of the saturated polyester resin, the unsaturated acrylic resin, the polyamide wax and the polyamide imide is 1 (0.8-1.5): 0.2-0.3): 0.3-0.5.
3. The medical hydrophilic coating solution according to claim 1, wherein the first photoinitiator and the second photoinitiator are each selected from one or more of 1-hydroxycyclohexyl phenyl ketone, diphenyl ethanone, 2, 4-dihydroxybenzophenone.
4. The medical hydrophilic coating solution according to claim 1, wherein the cross-linking agent is one or more of ethylene glycol dimethacrylate, polyethylene glycol diacrylate, 1, 4-butanediol diacrylate.
5. The medical hydrophilic coating solution according to claim 1, wherein the first solvent is one or more of ethanol, glycerol, ethyl acetate; the second solvent consists of two or more of ethanol, isopropanol, ethyl acetate and water.
6. The medical hydrophilic coating solution according to claim 1, wherein the top coat composition is composed of the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 1-2 parts of silane coupling agent, 2-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent.
7. A method for applying a medical hydrophilic coating solution according to any one of claims 1 to 6, characterized by comprising the following application steps:
s1, firstly, soaking a ox horn expander to be coated in a primer composition, and after the primer composition finishes coating, lifting the ox horn expander to be coated and carrying out irradiation curing at the next stage of an ultraviolet lamp to obtain the ox horn expander coated with the bottom layer;
s2, soaking the ox horn expander coated with the bottom layer in the finishing paint composition, and after finishing coating of the finishing paint composition, lifting the ox horn expander coated with the bottom layer and carrying out secondary irradiation curing under an ultraviolet lamp to obtain the ox horn expander coated with the hydrophilic coating.
8. The method for coating a medical hydrophilic coating solution according to claim 7, wherein the specific coating steps are as follows:
s1, firstly soaking a ox horn expander to be coated in a primer composition for 30-60S, after the primer composition finishes coating, extracting the ox horn expander to be coated at a constant speed of 0.5-1.0cm/S, and carrying out irradiation curing at the next stage of a 1200W ultraviolet lamp for 60-90S to obtain the ox horn expander coated with the bottom layer;
s2, soaking the ox horn expander coated with the bottom layer in the finishing paint composition for 20-30S, after finishing coating of the finishing paint composition, extracting the ox horn expander coated with the bottom layer at a constant speed of 0.5-1.0cm/S, and performing secondary irradiation curing for 90-180S under a 600W ultraviolet lamp to finish coating, thereby obtaining the ox horn expander coated with the hydrophilic coating.
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