CN115106142B - Multi-channel spacing adjustable pipetting device and cup dispensing system - Google Patents

Abstract

The invention discloses a multichannel interval-adjustable pipetting device, which comprises an adjusting mechanism and a pipetting mechanism, wherein the adjusting mechanism comprises an elastomer and an inflation and deflation device, and the pipetting mechanism comprises a plurality of pipetting guns and a negative pressure pipetting device; according to the invention, the elastic body is inflated and deflated by utilizing the inflation and deflation device, the matrix formed by arranging a plurality of rigid structures is controlled to be enlarged or contracted in equal proportion, the intervals of a plurality of rows and a large number of pipette guns can be rapidly adjusted, and the requirements of the intervals of test tubes on a sampling tube rack and the intervals of holes on a pipette plate are met, so that the problem that the interval adjustment of the plurality of rows of pipette guns cannot be realized in the existing multichannel pipette guns is solved. The multichannel interval adjustable pipetting device is novel and simple in structure, convenient to operate and beneficial to greatly improving the efficiency of a cup separating system. The invention also provides a cup separating system which comprises the transfer mechanism and the multichannel interval-adjustable pipetting device, so that the interval of a plurality of rows of pipetting guns and a large amount of pipetting guns can be quickly adjusted, and the efficiency of the cup separating system is greatly improved.

Description

Multi-channel spacing adjustable pipetting device and cup dispensing system

Technical Field

The invention relates to the field of medical devices, and in particular to a multi-channel spacing-adjustable pipetting device and a cup dividing system.

Background technique

Viral nucleic acid testing requires processes such as sample collection, sample pretreatment, viral nucleic acid extraction, nucleic acid testing, and result interpretation. Among them, before nucleic acid extraction, the sample needs to be inactivated, transferred to a plate, and other processes. Conventional inactivation and transfer work requires manual operation, including a series of complicated tasks such as information verification, opening the lid, pipetting, and closing the lid. The above process is referred to as "cup separation". In order to increase the throughput of nucleic acid testing, it is crucial to speed up the rate of the cup separation system. In order to further increase the detection throughput and reduce the workload of medical staff, the cup separation system is usually completed in an automated manner, that is, an automatic cup separation system. Among them, the pipetting step is the most time-consuming part of the operation of the cup separation system.

The specific implementation of pipetting is generally to use a manipulator to hold the pipette and move it to an open sampling tube, and then immerse the pipette tip into the sampling tube through a vertical feeding movement. A negative pressure is applied to the air pipe connected to the pipette, so that the pipette absorbs a certain amount of the liquid to be measured in the sampling tube. The pipette is then moved to the top of the pipetting plate through the manipulator, and the negative pressure is removed to inject the liquid to be measured. The corresponding hole in the pipetting plate completes the pipetting operation.

In order to further improve the throughput of the pipetting step and improve the efficiency of nucleic acid detection, it is necessary to use multiple pipettes at the same time to complete the above work, that is, a multi-channel pipette. However, since the spacing of the nucleic acid sampling tube rack (5-10ml sampling tube rack spacing is 20mm, 20-30ml sampling tube rack spacing is about 30mm) is different from the spacing of the commonly used 96-well plate (9mm), the pipetting operation cannot be achieved only by installing multiple fixed-position gun tips on the robotic arm, but requires the multi-channel pipette used to be able to be adjusted while maintaining the same spacing.

Currently, there are two main ways to achieve adjustable spacing of multi-channel pipetting guns: one is through certain mechanical structures, such as springs or linkage mechanisms; the other is through adding a motor. However, the application scope of the above two methods is generally a single-row pipette structure. Once a few pipettes are expanded to a multi-row pipette structure or a large number of pipettes, it will cause internal damage in the adjustment mechanism. There are problems such as too many parts, too complex structure, and high instability in use. Therefore, it is necessary to design a multi-channel spacing adjustable pipetting device that is simple in structure, highly stable in use, and suitable for adjusting the spacing of multiple rows of pipette guns.

Contents of the invention

The purpose of the present invention is to provide a multi-channel spacing adjustable liquid transfer device and a cup separation system to solve the problem that the spacing between multiple rows of liquid transfer guns cannot be adjusted in the existing multi-channel liquid transfer guns.

In order to achieve the above objects, the present invention provides the following solutions:

The invention provides a multi-channel spacing adjustable pipetting device, which includes:

Adjustment mechanism, the adjustment mechanism includes an elastomer and an inflation and deflation device. The elastomer is embedded with a number of rigid structures distributed in a matrix, and the outer contour geometric center of the matrix is consistent with the outer contour geometry of the elastomer. The centers coincide; the inflation and deflation device is connected to the elastomer, and the inflation and deflation device can cause the elastomer to inflate and expand or deflate and contract, so as to realize any two adjacent rows of the rigid structures in the matrix. The spacing between them and the spacing between any two adjacent columns of the rigid structures are enlarged or reduced equally;

A liquid suction mechanism, the liquid suction mechanism includes a plurality of pipette guns and a negative pressure liquid suction device, the pipette guns are arranged on the rigid structure, and the pipette guns are arranged in one-to-one correspondence with the rigid structure; Any pipette gun is provided with a gas transmission channel, and the gas transmission channel is connected to the negative pressure liquid suction device.

Optionally, the elastic body is a rectangular elastic airbag.

Optionally, the rigid structure is a rigid pipe, any one of the rigid pipes is provided through the top and bottom surfaces of the rectangular elastic airbag, and the outer wall of any one of the rigid pipes is sealingly connected to the rectangular elastic airbag, A radial convex ring is provided at the bottom of the inner wall of any of the rigid pipe fittings to fix the pipette gun.

Optionally, any side of the rectangular elastic airbag is configured as a telescopic accordion structural surface, and any one of the accordion structural surfaces can expand and contract in a direction perpendicular to the rigid pipe.

Optionally, a guide mechanism is also included, and the guide mechanism includes:

Support plate, the support plate is arranged above the rectangular elastic airbag, and two pairs of slide rails are provided on the support plate. Two of the slide rails in each pair of slide rails are located on the same straight line. The projection of the slide rail on the rectangular elastic airbag coincides with the two diagonals of the rectangular elastic airbag respectively;

Slide block, the slide block is slidingly matched with the slide rail, and one slide block is slidably installed on each of the slide rails;

Connecting rod, the top end of the connecting rod is connected to the slider, and the bottom end is connected to the corner of the rectangular elastic airbag.

Optionally, the support plate is a rectangular support plate.

Optionally, the four corners of the rectangular elastic airbag are provided with connecting ears, and the connecting ears are connected to the bottom end of the connecting rod.

Optionally, the connecting rod is a stud bolt, and the two ends of the stud bolt are respectively provided through the slide block and the connecting ear, and are locked and matched with the nut.

Optionally, the inflation and deflation device includes a gas pipeline and a gas source. One end of the gas pipeline is connected to the elastomer, and the other end is connected to the gas source.

Optionally, the negative pressure liquid suction device is a negative pressure air source, and each of the air delivery channels is connected to the negative pressure air source.

At the same time, the present invention proposes a cup dividing system, which includes a transfer mechanism and a multi-channel spacing adjustable pipetting device as described above. The transfer mechanism is used to lift and transfer the multi-channel spacing adjustable pipetting device.

Optionally, the transfer mechanism is a robot arm.

Compared with the prior art, the present invention has achieved the following technical effects:

The multi-channel spacing-adjustable pipetting device proposed by the present invention uses an inflation and deflation device to inflate and deflate the elastomer, and controls the equal-proportioned enlargement or reduction of a matrix arranged by several rigid structures, which can quickly enable multi-row and large-volume pipetting. The spacing of the guns can be quickly adjusted to meet the requirements of the spacing between the test tubes on the sampling tube rack and the spacing between the holes on the pipetting plate, thus solving the problem of the existing multi-channel pipetting guns that cannot adjust the spacing between multiple rows of pipetting guns. The above-mentioned multi-channel spacing-adjustable pipetting device has a novel and simple structure, is easy to operate, and is conducive to greatly improving the efficiency of the cup dividing system.

In addition, the present invention proposes a cup dividing system, which includes a transfer mechanism and the above multi-channel spacing adjustable pipetting device. The transfer mechanism is used to lift and transfer the multi-channel spacing adjustable pipetting device. By setting up the above-mentioned multi-channel spacing-adjustable pipetting device, the cup-dividing system can quickly adjust the spacing of multiple rows and large batches of pipetting guns, greatly improving the efficiency of the cup-dividing system.

Description of drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

FIG1 is a schematic structural diagram of an elastic body in an inflated state in a multi-channel spacing adjustable liquid transfer device disclosed in an embodiment of the present invention;

Figure 2 is a schematic structural diagram of the elastic body in a deflated and contracted state of the multi-channel spacing adjustable pipetting device disclosed in the embodiment of the present invention;

Figure 3 is a schematic structural diagram of the guide mechanism disclosed in the embodiment of the present invention;

FIG4 is a schematic structural diagram of a liquid aspiration mechanism disclosed in an embodiment of the present invention;

Figure 5 is a schematic structural diagram of the adjustment mechanism disclosed in the embodiment of the present invention;

Figure 6 is a finite element analysis result diagram of the elastomer filling and deflation process disclosed in the embodiment of the present invention.

Among them, the reference marks are:

100. Multi-channel spacing adjustable pipetting device;

1. Adjustment mechanism; 11. Elastomer; 111. Organ structural surface; 12. Rigid structure; 121. Radial convex ring; 13. Gas pipe;

2. Liquid suction mechanism; 21. Pipette gun; 211. Pipette tip; 22. Gas delivery channel;

3. Guide mechanism; 31. Support plate; 32. Slide rail; 33. Slide block; 34. Connecting rod; 35. Nut;

4. Connect the ears.

Detailed ways

The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

One of the objects of the present invention is to provide a multi-channel pipetting device with adjustable spacing to solve the problem of the existing multi-channel pipetting guns being unable to adjust the spacing of multiple rows of pipetting guns.

Another object of the present invention is to provide a cup-dividing system, which includes a transfer mechanism and a multi-channel spacing-adjustable pipetting device as described above, which can solve the problem of low working efficiency of the current cup-dividing system.

In order to make the above objects, features and advantages of the present invention more obvious and understandable, the present invention will be described in further detail below with reference to the accompanying drawings and specific embodiments.

Embodiment 1

As shown in Figures 1 to 2, this embodiment provides a multi-channel spacing adjustable pipetting device 100, which mainly includes an adjustment mechanism 1 and a liquid suction mechanism 2. The adjustment mechanism 1 includes an elastic body 11 and a gas filling and deflating device. , the elastic body 11 is embedded with a number of rigid structures 12 distributed in a matrix, and the outer contour geometric center of the matrix coincides with the outer contour geometric center of the elastic body 11; the inflation and deflation device is connected to the elastic body 11, and the inflation and deflation device can The elastic body 11 is inflated, expanded or deflated to achieve equal proportional enlargement or reduction of the spacing between any two adjacent rows of rigid structures 12 in the matrix and the spacing between any two adjacent columns of rigid structures 12; the liquid suction mechanism 2 It includes several pipette guns 21 and negative pressure suction devices. The pipette guns 21 are arranged on the rigid structure 12, and the pipette guns 21 and the rigid structure 12 are arranged in one-to-one correspondence; any pipette gun 21 is provided with a gas delivery device. Channel 22, the air delivery channel 22 is connected with the negative pressure liquid suction device. The above-mentioned multi-channel spacing adjustable pipetting device 100 specifically utilizes the elastic body 11 to enlarge or reduce the horizontal plane (lateral direction) in equal proportions during the process of inflating or deflating, thereby driving the multiple rows of pipetting guns placed therein to discharge. The spacing and column spacing can be enlarged or reduced in equal proportions to realize the adjustable spacing of multi-row and multi-channel pipetting guns.

In this embodiment, the elastomer 11 is preferably a rectangular elastic airbag. The rigid structure 12 is a rigid pipe, and any rigid pipe is set to penetrate the top and bottom surfaces of the rectangular elastic airbag. The outer wall of any rigid pipe is sealed and connected to the rectangular elastic airbag, and the setting of the rigid pipe does not affect the connectivity of the internal air cavity of the rectangular elastic airbag. A radial convex ring 121 is set at the bottom of the inner wall of any rigid pipe to form a stepped hole structure, so as to support the pipette 21 through the shoulder formed by the radial convex ring 121, so as to realize the axial fixation of the pipette 21 in the rigid pipe. The above-mentioned rectangular elastic airbag undergoes proportional deformation during the process of inflation and deflation, and the spacing is kept equal; the rigid structure 12 will not be deformed due to changes in pressure during the process of inflation and deflation of the rectangular elastic airbag.

In this embodiment, any side of the rectangular elastic airbag, that is, any side around it except the top surface and the bottom surface, is set as a telescopic accordion structural surface 111. Any one of the accordion structural surfaces 111 can move along the direction perpendicular to the rigid pipe. Directional telescoping. The axial direction of the rigid pipe is the vertical deformation direction, and the direction perpendicular to the vertical deformation direction is the transverse deformation direction. Since the rectangular elastic airbag of this embodiment is provided with organ structural surfaces 111 on the outer peripheral surface, it expands or contracts. When , there is basically no vertical deformation, but only horizontal deformation.

In this embodiment, it also includes a guide mechanism 3. The guide mechanism 3 includes a support plate 31, a slider 33 and a connecting rod 34. The support plate 31 is arranged above the rectangular elastic airbag. There are two pairs of slide rails 32 on the support plate 31. Two slide rails 32 in each pair of slide rails 32 are located on the same straight line, and the projections of the two pairs of slide rails 32 on the rectangular elastic airbag respectively coincide with the two diagonals of the rectangular elastic airbag. That is, the two pairs of slide rails 32 are arranged according to the rectangular shape. The two diagonal lines of the elastic airbag are arranged; the slider 33 is slidingly matched with the slide rail 32, and a slider 33 is slidably installed on each slide rail 32; the top end of the connecting rod 34 is connected to the slider 33, and the bottom end is connected to the rectangular Corner connections for elastic airbags. Wherein, the support plate 31 is preferably a rectangular support plate 31, and the center of the rectangular support plate 31 is coaxially arranged with the center of the rectangular elastic airbag. The above-mentioned guide mechanism 3 is to further limit the deformation of the rectangular elastic airbag, ensure the proportional deformation of the rectangular elastic airbag, and at the same time realize the axial fixing and guiding function of the rectangular elastic airbag. Among them, the axial fixing is to prevent the rectangular elastic airbag from deforming. When the airbag falls, the guide is to make the deformation of the rectangular elastic airbag more controllable and stable.

As a further preferred solution, limiting structures can be provided at both ends of the slide rail 32. When the slider 33 slides to the extreme positions at both ends, it corresponds to two adjustable spacings.

In this embodiment, the four corners of the rectangular elastic airbag are provided with connecting ears 4, and the connecting ears 4 are connected to the bottom end of the connecting rod 34. As a preferred method, the aforementioned connecting rod 34 adopts stud bolts, and the two ends of the stud bolts are disposed through the slider 33 and the connecting lug 4 respectively, and are locked and matched with the nuts 35 .

In this embodiment, the aforementioned inflation and deflation device includes a gas pipe 13 and a gas source. One end of the gas pipe 13 is connected to the elastic body 11 and the other end is connected to the gas source. As a preferred method, the air-conveying pipe 13 and the elastic body 11 are preferably sealed and connected by hot-melt bonding or a sealing gasket.

In this embodiment, the aforementioned negative pressure liquid suction device is preferably a negative pressure air source. The air delivery channel 22 of each pipette gun 21 is connected to the negative pressure air source. Each air delivery channel 22 may correspond to a negative pressure air source. The air source may also be a negative pressure air source shared by multiple air delivery channels 22 .

In this embodiment, the elastic body 11 undergoes rapid and obvious deformation during the process of inflation and deflation due to its high elasticity. Elastomer 11 requires high tensile rebound rate and high elongation at break, and natural latex can be selected as its production material. In order to clarify the principle of elastomer 11 to achieve equal spacing changes and clarify the application range of equal spacing, a rectangle is used for finite element analysis. As shown in Figure 6, the theory of equal-spaced deformation of the elastomer 11 during the inflation and deflation process was carried out in COMSOL. In the structure on the left in Figure 6, each edge is exerted perpendicular to the corresponding edge outward. The unit length is equal to the tensile force, and the center is set as the fixed point. The resulting expanded structure is as shown in the structure on the right in Figure 6. It can be found that the spacing between the rigid structures 12 in the figure is almost kept proportionally expanded. Therefore, it can be proved that as long as the arrangement center of the rigid structure 12 array coincides with the geometric center of the boundary pattern of the elastic body 11, the elastic body 11 can maintain equidistant deformation, further reducing the difficulty of designing the elastic body 11.

In this embodiment, the organ structural surface 111 (which can also be called a "folding structure") can ensure that the size of the rectangular elastic airbag only changes in the transverse direction during the inflating and deflation process; the rectangular elastic airbag can ensure the distance between the liquid suction mechanisms. are equal, and shrink or expand in equal proportion when the air bag pressure changes; the guide mechanism can increase the stability of the rectangular elastic air bag when it is deformed. When in use, the rectangular elastic air bag can be adjusted to switch between the two set pressures. The multi-channel spacing-adjustable pipetting device 100 of this embodiment has a simple structure and can simultaneously adjust the spacing of multiple rows and a large number of pipetting guns while keeping the spacing consistent. Taking the rigid structure 12 on the rectangular elastic air bag uniformly distributed in a 5×5 matrix as an example, the working principle of the above-mentioned multi-channel spacing adjustable pipetting device 100 in this embodiment is described in detail below. The main method is to adjust the multi-channel spacing. The pipetting device 100 adjusts the 5×5 matrix distribution of the pipetting guns from the test tube row spacing on the sampling tube rack to the spacing of a 96-well plate (a 96-well plate is a kind of pipetting plate and is an existing technology). Only 2 stable spacings are needed. The specific operating steps and processes are as follows:

Taking the deflation process as an example, in the initial state, the rectangular elastic airbag is filled with gas (higher pressure), the accordion structure surface 111 is propped up and wrinkle-free, and the structural dimensions and spacing dimensions of the rigid structure 12 on the rectangular elastic airbag are designed so that the row spacing of the rigid structure 12 is the row spacing of the test tubes on the sampling tube rack (assuming it is 20 mm), and the spacing between two adjacent rigid structures 12 in each row of rigid structures 12 is equal to the spacing between two adjacent test tubes in each row of test tubes on the sampling tube rack, the spacing of the pipette gun 21 installed in the rigid structure 12 is also the same as the above two spacings, and at this time the slider 33 is at the starting position (outer edge position) of the slide rail 32. The multi-channel spacing adjustable liquid transfer device 100 is moved as a whole by corresponding moving auxiliary devices, such as a manipulator, so that the tips 211 of the multiple liquid transfer guns 21 are inserted into the corresponding test tubes, and negative pressure is applied to the corresponding liquid transfer guns 21 through the gas supply channel 22, so that the liquid transfer guns 21 absorb the liquid to be tested in the corresponding test tubes, and then the entire multi-channel spacing adjustable liquid transfer device 100 is moved upward to the initial position; at the same time, the gas supply pipe 13 extracts the gas in the rectangular elastic airbag, so that the rectangular elastic airbag shrinks in the horizontal direction in equal proportion, and each accordion structure surface 111 begins to fold according to the original fold surface, so that the matrix formed by the rigid structure 12 The ratio is reduced, and the spacing between the pipette guns 21 begins to decrease proportionally until, under a certain pressure (at this time, the slider 33 generally runs to the innermost end of the slide rail 32), the row spacing of the pipette guns 21 and the spacing between two adjacent pipette guns 21 in each row of the pipette guns 21 are respectively the same as the row spacing (for example, 9 mm) and column spacing of the holes on the 96-well plate. At this time, the entire multi-channel adjustable spacing pipetting device 100 is moved downward, and the pipette guns 21 are inserted into the corresponding holes of the 96-well plate. Then, the negative pressure in the gas transmission channel 22 is removed, so that the liquid to be tested stored in the pipette gun 21 is released into the corresponding holes of the 96-well plate, and the pipetting process is completed.

It can be seen from the above that by using the multi-channel spacing adjustable pipetting device 100 to adjust the 5×5 matrix distribution of pipetting guns from the test tube row spacing on the sampling tube rack to the spacing of the 96-well plate, only two stable spacings are needed, so The specific pressures of two different spacings can be tested in advance. When using, you only need to control the pressure to switch between these two values. The overall adjustment mechanism may not have high accuracy. Since the hole diameter of the 96-well plate is 8.5mm, the accuracy requirements are not high, so the rectangular elastic airbag can complete the above-mentioned spacing adjustment work. Compared with the existing technology, the multi-channel spacing adjustable pipetting device 100 of this technical solution can quickly adjust the spacing of multiple rows and a large number of pipetting guns, and pipetting from the sampling tube rack to the 96-well plate only takes one time. It can complete the pipetting work of 25 pipette guns 21 or even more pipette guns 21. It has a simple structure and is easy to operate, which greatly improves the efficiency of the cup dividing system.

Embodiment 2

This embodiment proposes a cup dividing system, which includes a transfer mechanism and the multi-channel spacing adjustable pipetting device 100 as described in Embodiment 1. The transfer mechanism is used to lift and transfer the multi-channel spacing adjustable pipetting device 100 to assist The multi-channel spacing-adjustable pipetting device 100 completes the cup dividing operation. Among them, the transfer mechanism can be a manipulator or an existing two-dimensional or three-dimensional adjustment platform.

The above-mentioned cup-dividing system proposed in this embodiment can realize rapid adjustment of the distance between multiple rows and large batches of pipetting guns by setting up a multi-channel distance-adjustable pipetting device 100, which greatly improves the efficiency of the cup-dividing system.

It should be noted that it is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention, and any figure mark in the claims should not be regarded as limiting the claims involved.

Specific examples are used in the present invention to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method and the core idea of the present invention; at the same time, for those of ordinary skill in the art, based on this The idea of the invention will be subject to change in the specific implementation and scope of application. In summary, the contents of this description should not be construed as limitations of the present invention.

Claims (10)

1. A multi-channel spacing adjustable pipetting device, which is characterized in that it includes: The regulating mechanism comprises an elastic body and an inflation and deflation device, wherein a plurality of rigid structures distributed in a matrix are embedded on the elastic body, and the outer contour geometric center of the matrix coincides with the outer contour geometric center of the elastic body; the inflation and deflation device is connected to the elastic body, and the inflation and deflation device can inflate or deflate the elastic body, so as to realize that the spacing between any two adjacent rows of the rigid structures in the matrix and the spacing between any two adjacent columns of the rigid structures are equally enlarged or reduced; The liquid suction mechanism includes a plurality of pipettes and a negative pressure liquid suction device. The pipettes are arranged on the rigid structure, and the pipettes and the rigid structure are arranged one by one. Any of the pipettes is provided with an air supply channel, and the air supply channel is connected to the negative pressure liquid suction device. 2. The multi-channel spacing-adjustable pipetting device according to claim 1, wherein the elastic body is a rectangular elastic air bag. 3. The multi-channel spacing adjustable pipetting device according to claim 2 is characterized in that the rigid structure is a rigid tube, any one of the rigid tubes is arranged to pass through the top and bottom surfaces of the rectangular elastic airbag, the outer wall of any one of the rigid tubes is sealed and connected to the rectangular elastic airbag, and the bottom of the inner wall of any one of the rigid tubes is provided with a radial convex ring to fix the pipette gun. 4. The multi-channel spacing adjustable pipetting device according to claim 3, characterized in that any side of the rectangular elastic air bag is set as a telescopic accordion structural surface, and any one of the accordion structural surfaces can Expand and contract in a direction perpendicular to the rigid pipe. 5. The multi-channel spacing-adjustable pipetting device according to any one of claims 2 to 4, characterized in that it also includes a guide mechanism, and the guide mechanism includes: Support plate, the support plate is arranged above the rectangular elastic airbag, and two pairs of slide rails are provided on the support plate. Two of the slide rails in each pair of slide rails are located on the same straight line. The projection of the slide rail on the rectangular elastic airbag coincides with the two diagonals of the rectangular elastic airbag respectively; Slide block, the slide block is slidingly matched with the slide rail, and one slide block is slidably installed on each of the slide rails; Connecting rod, the top end of the connecting rod is connected to the slider, and the bottom end is connected to the corner of the rectangular elastic airbag. 6. The multi-channel spacing-adjustable pipetting device according to claim 5, characterized in that four corners of the rectangular elastic air bag are provided with connecting ears, and the connecting ears are connected to the bottom end of the connecting rod. 7. The multi-channel spacing adjustable pipetting device according to claim 6, wherein the connecting rod is a stud bolt, and both ends of the stud bolt penetrate the slider and the connecting ear respectively. Set and tighten with nut. 8. The multi-channel spacing-adjustable pipetting device according to any one of claims 1 to 4, characterized in that the inflation and deflation device includes a gas pipe and a gas source, and one end of the gas pipe is connected to the elastic The other end is connected to the gas source. 9. The multi-channel spacing adjustable liquid transfer device according to any one of claims 1 to 4, characterized in that the negative pressure liquid suction device is a negative pressure air source, and each of the air transmission channels is connected to the negative pressure air source. 10. A cup dividing system, characterized by comprising a transfer mechanism and a multi-channel spacing adjustable pipetting device according to any one of claims 1 to 9, the transfer mechanism being used to lift and transfer the multi-channel Pipetting device with adjustable spacing.