CN115097074A - A simulation device and experimental method for the release of harmful substances in cosmetics - Google Patents

Abstract

The invention discloses a cosmetic harmful substance release simulation device, which comprises: the simulation medium storage pool is internally provided with a first simulation medium, and the bottom of the simulation medium storage pool is provided with a second simulation medium for simulating a real water environment; the simulated skin release device is positioned on the upper part of the second simulated medium, and part of the medical simulated skin is kept to be immersed in the first simulated medium in the whole process, so that the motion state of a person in the first simulated medium under different environmental scenes and the condition that the skin of the person releases cosmetic harmful substances are simulated; the simulated skin release device comprises a motor and a speed regulator which are fixed at the top of the simulated medium storage pool, PVC pipes which are fixed at two sides of the simulated medium storage pool, and medical simulated skin which is fixed on the PVC pipes. The device can simulate the dynamic condition of cosmetics released by human skin in water environment, meet the requirement of dynamic analysis on harmful substances released by samples and evaluate environmental risks of different cosmetic components more objectively and truly.

Description

A simulation device and experimental method for the release of harmful substances in cosmetics

technical field

The invention relates to the field of simulated detection of environmental pollution, in particular to a simulation device and an experimental method for the release of harmful substances in cosmetics.

Background technique

In recent years, the use scale of cosmetics has been increasing year by year, especially with the improvement of people's awareness of sun protection, as a cosmetic for ultraviolet (UVA/UVB) protection, sunscreen has been widely accepted and used by the public. Cosmetics, as composite biochemical products, involve various additives such as emulsifiers, antioxidant preservatives, surfactants, and adhesives added in the production process. Many of these additives have been proven to directly threaten environmental health. In the fields of medical safety and hygiene, the release of harmful substances in cosmetics has been incorporated into the government supervision system, and there are corresponding detection methods and simulation devices. In the field of environmental monitoring, the detection and risk assessment of harmful substances released by cosmetics is still in its infancy, but it has also received extensive attention from countries around the world.

Due to the large difference between the simulation of environmental conditions and the simulation of storage conditions of pharmaceuticals and cosmetics, the more mature related simulation devices cannot meet the expectations of simulated environmental conditions. There are two main reasons: First, the environmental factors are complex and diverse. Once the harmful substances in cosmetics enter the environment, their exposure time in the environment is long, so the simulated release device is required to simulate the actual environmental factors as much as possible to evaluate the dynamic changes and fate of harmful substances released by cosmetics. Second, people are often in motion in the water environment, and the harmful substances in cosmetics are mainly released into the environment from the skin. Traditional simulation devices often ignore the motion state during release, and the sample carrier used is far from human skin. This can lead to changes in the behavior, concentration, fate, etc. of hazardous substances entering the environment. Therefore, a simulation device that can not only meet the simulation of various types of environmental factors, but also more closely matches the motion state of the human body and the release of cosmetics from the skin in the real environment, still belongs to the gap in the detection field that needs to be filled.

SUMMARY OF THE INVENTION

In order to solve the above-mentioned technical problems in this field, the primary purpose of the present invention is to provide a simulation device for the release of harmful substances in cosmetics, which can simulate the dynamic situation of cosmetics released from human skin in a water environment and meet the requirements for the release of harmful substances from samples. The need for dynamic analysis and a more objective and realistic environmental risk assessment for different cosmetic ingredients.

Another object of the present invention is to provide an experimental method using the above-mentioned cosmetic harmful substance release simulation device.

In order to achieve the above object, the present invention adopts the following technical solutions:

A cosmetic harmful substance release simulation device, comprising:

A simulation medium storage pool, with a first simulation medium placed inside and a second simulation medium placed at the bottom for simulating a real water environment;

The simulated skin release device is located on the upper part of the second simulation medium, and keeps part of the medical simulation skin immersed in the first simulation medium throughout the whole process, which is used to simulate the movement state of people in the first simulation medium under different environmental scenarios and the harmful cosmetics released by human skin. material condition;

Wherein, the simulated skin release device includes a motor and a governor fixed on the top of the simulated medium storage pool, PVC pipes fixed on both sides of the simulated medium storage pool, and a medical device fixed on the PVC pipe Simulation skin.

In some preferred technical solutions, the PVC pipe is fixed on both sides of the simulation medium storage pool through an optical axis and a bearing, and is placed in the middle of the simulation medium storage pool; the medical simulation skin is fixed on the PVC pipe by a nylon tie, and the The motor drives the optical axis through the synchronous wheel and the synchronous belt to drive the PVC pipe to rotate, and the PVC pipe is immersed in the first simulation medium for half of the whole process.

In some preferred technical solutions, the simulating medium storage tank is a cuboid glass container; the first simulating medium is selected from at least one of deionized water, natural river water, and natural sea water; the second simulating medium is a bottom At least one of mud and bottom sand.

In some preferred technical solutions, the above-mentioned cosmetic harmful substance release simulation device further includes:

a wave-making pump connected to the simulated medium storage tank through a suction cup, for adjusting the flow speed, flow rate and wave length of the first simulated medium in the simulated medium storage tank;

a thermostat connected to the simulated medium storage pool through a suction cup, for adjusting different temperatures of the simulated environment in the simulated medium storage pool;

The LED lamp fixed on the simulated medium storage tank by the holder is used to simulate the release of harmful substances in cosmetics under different light types and irradiation intensities in the environment;

The automatic water replenisher connected with the simulation medium storage tank through the suction cup is used for maintaining the water level of the first simulation medium in the simulation medium storage tank.

In some preferred technical solutions, the wave making pump includes a water pump and a controller; the water pump is located on the surface layer and the bottom of the first simulation medium respectively, and requires full immersion in the first simulation medium stored in the simulation medium storage tank.

In some preferred technical solutions, the temperature controller includes a heating plate and a controller; the heating plate is located on one side of the simulation medium storage pool, and requires full immersion in the first simulation medium.

In some preferred technical solutions, the LED lamp includes an LED lamp bead and a controller; the LED lamp bead is located on the upper part of the simulation medium storage tank, and the controller is fixed on a wooden board on the top of the simulation medium storage tank.

In some preferred technical solutions, the automatic water replenisher includes a floating ball device and a water pump; the floating ball device is located on one side of the simulated medium storage tank, and the floating ball device is immersed in the first simulated medium throughout the entire process. The water pump is placed in the water bucket outside the simulated medium storage tank, the water pump is completely immersed in the supplementary medium in the water bucket throughout the whole process, and the floating ball device and the water pump are connected through the rubber pipeline.

The present invention also provides an experimental method using the above-mentioned cosmetic harmful substance release simulation device, comprising the following steps:

S1, apply a cosmetic product sample on the surface of the medical simulation skin, and then fix the medical simulation skin on the PVC pipe through a nylon tie;

S2, simulating the flow velocity, flow rate and wave length of the first simulated medium under different environmental scenarios by the wave making pump;

S3, simulating the temperature of different environmental scenarios through the thermostat;

S4, simulating illumination types and irradiance intensities in different environmental scenarios through the LED lights;

S5, simulating the motion state of people in the first simulation medium under different environmental scenarios and the release of cosmetic harmful substances from human skin through the simulated skin release device;

S6. Connect the water pump through the floating ball device in the automatic water replenisher to realize automatic water replenishment and keep the water level consistent;

S7. Collect the harmful substances released by the samples by sampling the first simulation medium and the second simulation medium in real time, and then perform dynamic analysis.

Compared with the prior art, the present invention has the following technical effects:

In the present invention, a simulation medium storage tank including a first simulation medium and a second simulation medium is used to simulate a real water environment, and a simulation skin release device located on the upper part of the second simulation medium is used to keep part of the medical simulation skin immersed in the first simulation medium throughout the whole process. In the simulation medium, it is used to simulate the movement state of people in the first simulation medium under different environmental scenarios and the release of harmful substances in cosmetics from human skin, which can realize a more realistic simulation of environmental conditions, especially the simulation of human skin and human skin. The simulation of the motion state in the water environment can analyze the dynamic process and the fate of harmful substances released from cosmetics, and can more efficiently discover harmful substances that are not currently under key monitoring, so as to meet the dynamic analysis of the release of harmful substances from samples demand and a more objective and realistic environmental risk assessment for different cosmetic ingredients.

Description of drawings

FIG. 1 is a schematic structural diagram of a cosmetic harmful substance release simulation device according to an embodiment of the present invention.

2 is a schematic structural diagram of the simulated skin release device in the cosmetic harmful substance release simulation device according to an embodiment of the present invention;

In the figure: 1. Simulated medium storage tank; 1.1. The first simulated medium; 1.2, The second simulated medium; 2. The wave pump; 2.1, the water pump; 2.2, the controller; 3, the thermostat; 3.2, controller; 4, LED light; 4.1, light bulb; 4.2, controller; 4.3, wooden board; 5, simulated skin release device; 5.1, motor; 5.1.1, synchronous wheel; 5.1.2, synchronous belt; 5.2, Governor; 5.3, PVC pipe; 5.3.1, optical axis; 5.3.2, bearing; 5.4, medical simulation skin; 5.4.1, nylon cable tie; 5.5, product sample; 6, automatic water replenisher; 6.1, float Ball device; 6.2, water pump; 6.3, bucket; 6.4, supplementary medium; 6.5, rubber pipeline.

Detailed ways

The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention. In addition, it should be noted that, for the convenience of description, the drawings only show some but not all structures related to the present invention.

As shown in Figure 1, a simulation device for the release of harmful substances in cosmetics includes:

The simulation medium storage pool 1 has a first simulation medium 1.1 placed inside and a second simulation medium 1.2 placed at the bottom for simulating a real water environment;

The wave pump 2 connected with the simulated medium storage pool 1 through the suction cup is used to adjust the flow speed, flow rate and wave length of the first simulated medium 1.1 in the simulated medium storage pool 1;

a temperature controller 3 connected to the simulated medium storage pool 1 through a suction cup, for adjusting different temperatures of the simulated environment in the simulated medium storage pool 1;

The LED lamp 4 fixed on the simulated medium storage tank 1 by the fixture is used to simulate the release of harmful substances in cosmetics under different light types and irradiation intensities in the environment;

The automatic water replenisher 6 connected with the simulation medium storage pool 1 through the suction cup is used to maintain the water level of the first simulation medium 1.1 in the simulation medium storage pool 1;

The simulated skin release device 5 is located on the upper part of the second simulation medium 1.2, and keeps part of the medical simulation skin 5.4 immersed in the first simulation medium 1.1 throughout the whole process, so as to simulate the motion state of a person in the first simulation medium 1.1 under different environmental scenarios and The release of cosmetic harmful substances from human skin;

In a preferred embodiment of the present invention, the simulated skin releasing device 5 includes a motor 5.1 and a governor 5.2 fixed on the top of the simulated medium storage pool 1 , and a motor 5.1 and a speed governor 5.2 fixed on both sides of the simulated medium storage pool 1 . The PVC pipe 5.3, and the medical simulation skin 5.4 fixed on the PVC pipe 5.3; the medical simulation skin 5.4 is fixed on the PVC pipe 5.3 with nylon cable ties 5.4.1 to simulate human skin, and the sample product 5.5 is evenly applied to the medical simulation skin to simulate the release of harmful substances in cosmetic samples from the skin in different environmental scenarios.

In a preferred embodiment of the present invention, the storage tank is a coverless glass (or acrylic) storage tank; the inside of the tank is the first simulation medium 1.1, and the specific type can be selected according to different environmental scenarios. Deionized water, natural river water, natural seawater, etc. Different media, the water storage capacity is about 30L; the specific type of the second simulated medium 1.2 in the pool can be selected according to different environmental scenarios, such as bottom mud, bottom sand, etc.; the simulated medium storage pool 1 is provided with a wave pump 2 and a temperature controller 3, The two are respectively equipped with suction cups to connect with the simulated medium storage pool 1. The wave making pump 2 can control the flow rate and flow of the water pump 2.1 through the controller 2.2, and the thermostat 3 can control the temperature of the heating plate through the controller 3.2; the top of the simulated medium storage pool 1 There is also an LED light 4, which is connected with the storage pool 1 through a buckle; the simulated skin release device 5 is located in the middle of the simulated medium storage pool 1, which is connected and fixed with the simulated medium storage pool 1 through a wooden board 4.3 and a corner code; There is also an automatic water replenisher 6 outside the storage tank 1. The automatic water replenisher 6 is fixed in the simulated medium storage tank 1 through a suction cup, and is connected to the water bucket 6.3 through the floating ball device 6.1 and the rubber pipeline 6.5, and the supplementary medium 6.4 is automatically added during the experiment. .

As shown in FIG. 2 , the simulated skin release device 5 includes a motor 5.1, a governor 5.2, a PVC pipe 5.3 and a medical simulated skin 5.4; wherein, the motor 5.1 and the governor 5.2 are fixed to the simulated medium storage tank 1. On the wooden board 4.3 at the top, the PVC pipe 5.3 is fixed to the wooden board 4.3 on both sides of the simulated medium storage pool 1 through the optical axis 5.3.1 and the bearing 5.3.2, placed in the middle of the simulated medium storage pool 1, and the medical simulation skin 5.4 is tied by nylon. The belt 5.4.1 is fixed on the PVC pipe 5.3 to simulate human skin, and the cosmetic sample 5.5 is applied on the medical simulation skin 5.4. The motor 5.1 drives the optical axis 5.3.1 through the synchronous wheel 5.1.1 and the synchronous belt 5.1.2, and then drives the PVC pipe 5.3 to rotate, which is used to simulate the movement of a person in the first simulation medium 1.1. At the same time, the PVC pipe 5.3 is required to be halfway through the whole process. Immerse in the first simulation medium 1.1 to realize the dynamic analysis of harmful substances in cosmetics in different environmental media.

In a preferred embodiment of the present invention, the present invention also provides a simulation experiment method using the above device, comprising the following steps:

S1. Configure water samples corresponding to the water environment to be simulated. For example, artificial seawater needs to be prepared if the seawater environment is to be simulated. The main components are: NaCl24.5g/L, MgCl224g/L, KCl0.73g/L, MgSO43.3g/L L, NaHCO 30.2g/L, CaCl ₂ 1.1g/L, NaBr 0.28g/L, pH=7.02, or prepare natural seawater, and inject into simulated medium storage tank 1 after preparation; apply sunscreen as cosmetic sample product 5.5 on On the surface of the medical simulation skin 5.4, after the cosmetic is formed into a film, the medical simulation skin 5.4 is fixed on the PVC pipe 5.3 through a nylon cable tie 5.4.1 to simulate human skin;

S2. Adjust the wave making pump 2, and adjust the water pump 2.1 through the controller 2.2 to simulate the flow speed, flow rate and wave length of the first simulated medium 1.1 under the target environment scenario;

S3, adjust the thermostat 3, and adjust the heating plate 3.1 through the controller 3.2 to simulate the temperature of the target environment scene;

S4, adjust the LED light 4, and adjust the light bulb 4.1 through the controller 4.2 to simulate the illumination type and irradiance intensity under the target environment scene;

S5, adjust the speed of the motor 5.1 through the simulated skin release device 5, and adjust the motor 5.1 through the speed controller 5.2 to simulate the movement state, movement speed of people in the simulated medium under different environmental scenarios and the situation that human skin releases cosmetic harmful substances;

S6. Connect the water pump 6.2 with the floating ball device 6.1 in the automatic water replenisher 6 to realize automatic water replenishment and keep the water level consistent;

S7. Real-time sampling of the simulation medium 1.1 and simulation medium 2 1.2 after reaching the custom simulation time, collecting sunscreen as the harmful substances released by the cosmetic sample product 5.5, and then dynamically analyzing the content of the sunscreen.

It was found that with the increasing popularity of physical sunscreens containing nano-metal oxides (nano-titanium dioxide, zinc oxide) and chemical sunscreens containing oxybenzone and other substances, the pollution of these substances to the water environment may continue to rise. By simulating the release of the cosmetic harmful substance release simulation device of the present invention, the amount of the harmful substance released into the water body by the sunscreen can be estimated, and then the harmful substance can be supervised.

The above content is a further detailed description of the present invention in combination with specific preferred embodiments, and it cannot be considered that the specific implementation of the present invention is limited to these descriptions. For those of ordinary skill in the technical field of the present invention, without departing from the concept of the present invention, some simple deductions or substitutions can be made, which should be regarded as belonging to the protection scope of the present invention.

Claims (9)

1. a cosmetic harmful substance release simulation device, is characterized in that, comprises: A simulation medium storage pool (1), a first simulation medium (1.1) is placed inside and a second simulation medium (1.2) is placed at the bottom, for simulating a real water environment; The simulated skin release device (5) is located on the upper part of the second simulation medium (1.2), and keeps part of the medical simulation skin (5.4) immersed in the first simulation medium (1.1) throughout the whole process, so as to simulate the human being in the first simulation medium (1.1) under different environmental scenarios Simulate the state of motion in the medium (1.1) and the release of cosmetic harmful substances from human skin; Wherein, the simulated skin release device (5) comprises a motor (5.1) and a governor (5.2) fixed on the top of the simulated medium storage pool (1), and two fixed on the simulated medium storage pool (1) The PVC pipe (5.3) on the side, and the medical simulation skin (5.4) fixed on the PVC pipe (5.3). 2. The cosmetic harmful substance release simulation device according to claim 1, wherein the PVC pipe (5.3) is fixed to the simulation medium storage tank (1) through an optical axis (5.3.1) and a bearing (5.3.2). ) on both sides of the simulation medium storage pool (1); the medical simulation skin (5.4) is fixed on the PVC pipe (5.3) by the nylon tie (5.4.1), and the motor (5.1) is passed through the synchronous wheel (5.1.1) and the timing belt (5.1.2) drive the optical axis (5.3.1) and then drive the PVC pipe (5.3) to rotate, and the PVC pipe (5.3) is immersed in the first simulation medium (1.1) halfway through. 3. The cosmetic harmful substance release simulation device according to claim 1, wherein the simulation medium storage tank (1) is a rectangular parallelepiped glass container; the first simulation medium (1.1) is selected from deionized water, At least one of natural river water and natural seawater; the second simulation medium (1.2) is at least one of bottom mud and bottom sand. 4. The cosmetic harmful substance release simulation device according to claim 1, further comprising: a wave-making pump (2) connected to the simulated medium storage tank (1) through a suction cup, for adjusting the flow speed, flow rate and wave length of the first simulated medium (1.1) in the simulated medium storage tank (1); a temperature controller (3) connected to the simulated medium storage pool (1) through a suction cup, for adjusting different temperatures of the simulated environment in the simulated medium storage pool (1); The LED lamp (4) fixed on the simulated medium storage tank (1) by the fixture is used to simulate the release of harmful substances in cosmetics under different illumination types and radiation intensities in the environment; An automatic water replenisher (6) connected to the simulation medium storage pool (1) through a suction cup is used to maintain the water level of the first simulation medium (1.1) in the simulation medium storage pool (1). 5. The cosmetic harmful substance release simulation device according to claim 4, wherein the wave making pump (2) comprises a water pump (2.1) and a controller (2.2); the water pump (2.1) is located in the first The surface and bottom of the first simulation medium (1.1) are required to be immersed in the first simulation medium (1.1) stored in the simulation medium storage pool (1) throughout the entire process. 6. The cosmetic harmful substance release simulation device according to claim 4, wherein the temperature controller (3) comprises a heating plate (3.1) and a controller (3.2); the heating plate (3.1) is located at the The simulation medium storage tank (1) side is required to be immersed in the first simulation medium (1.1) throughout the whole process. 7. The cosmetic harmful substance release simulation device according to claim 4, wherein the LED lamp (4) comprises an LED lamp bead (4.1) and a controller (4.2); the LED lamp bead (4.1) is located in the On the upper part of the simulation medium storage pool (1), the controller (4.2) is fixed on the wooden board (4.3) on the top of the simulation medium storage pool (1). 8. The cosmetic harmful substance release simulation device according to claim 4, wherein the automatic water replenisher (6) comprises a float device (6.1) and a water pump (6.2); the float device (6.1) is located in the On one side of the simulated medium storage pool (1), the floating ball device (6.1) is fully immersed in the first simulated medium (1.1), and the water pump (6.2) is placed outside the simulated medium storage pool (1) In the water bucket (6.3), the water pump (6.2) is completely immersed in the supplementary medium (6.4) in the water bucket (6.3), and the float device (6.1) and the water pump (6.2) pass through the Connect the rubber tubing (6.5). 9. a kind of experiment method that adopts the cosmetic harmful substance release simulation device described in any one of claim 1-8, comprises the steps: S1. Apply the cosmetic product sample (5.6) on the surface of the medical simulation skin (5.4), and then fix the medical simulation skin (5.4) on the PVC pipe (5.3) through a nylon tie (5.5); S2, simulating the flow velocity, flow rate and wave length of the first simulated medium (1.1) under different environmental scenarios by using the wave making pump (2); S3. The temperature of different environmental scenarios is simulated by the temperature controller (3); S4, simulating illumination types and irradiance intensities under different environmental scenarios through the LED lamp (4); S5. The simulated skin releasing device (5) simulates the motion state of a person in the first simulated medium (1.1) under different environmental scenarios and the situation that the human skin releases cosmetic harmful substances; S6. Connect the water pump (6.2) through the floating ball device (6.1) in the automatic water replenisher (6) to realize automatic water replenishment and keep the water level consistent; S7. Collect the harmful substances released by the samples by sampling the first simulation medium (1.1) and the second simulation medium (1.2) in real time, and then perform dynamic analysis.

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