CN1150027A - Method for extracting available composition of chrysanthemum flower - Google Patents
Method for extracting available composition of chrysanthemum flower Download PDFInfo
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- CN1150027A CN1150027A CN 95117457 CN95117457A CN1150027A CN 1150027 A CN1150027 A CN 1150027A CN 95117457 CN95117457 CN 95117457 CN 95117457 A CN95117457 A CN 95117457A CN 1150027 A CN1150027 A CN 1150027A
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- ethanol
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Abstract
A process for extracting active components from white chrysanthemum flower includes extracting twice with 55-75% of alcohol at 50-70 deg.C respectively for 3-3.5 hr and then 20-30 min, extracting with water, merging three liquid extracts, filtering, and pressure-reducing concentration, and features high extract rate of total flavone up to 85% or more and adapting to industrial production.
Description
The present invention relates to a kind of ethanol and moisture step extraction process of utilizing, extract the method for effective ingredient in the Flos Chrysanthemi.
Flos Chrysanthemi contains multiple composition, and what wherein have the curative effect effect is the total flavones thing.At present, Flos Chrysanthemi is extensively introduced in the health food.Therefore, the method how research extract medicable composition in the Flos Chrysanthemi receives much attention.
" Wuhan light science and technology " 1985, (4) have introduced the manufacturing process of chrysanthemum crystals in " Flos Chrysanthemi beverage " literary composition of Ye Hua etc.Reported the test that different process extracts effective ingredient in the Flos Chrysanthemi simultaneously, method is the normal pressure decocting in water, the decocting in water that pressurizes, add water distillation, ethanol extraction and ethanol extracting in water, by relatively beverage quality, Flos Chrysanthemi effective component extraction rate and equipment investment etc., determined that ethanol adds the technology that water extracts altogether, this method be with Flos Chrysanthemi in ethanol more than the lixiviate 96h, about residue reuse water extraction 2h, merge secondary raffinate.Its weak point is that the production cycle is long, and being used for actual production has certain difficulty; And in the method concentration of ethanol, solid-liquid ratio, extraction temperature are not all reported, and these influence the key factor of extraction ratio exactly; In addition in this article also the efficiency index of undeclared extraction be what thing.
" Food Science " 1994, (8) have reported Liao Liang etc. " research of Folium Ginkgo total flavones extracting method ".Their Fen Do adopts water reflux extraction, 70% ethanol to overflow lifting manipulation 95% ethanol extraction and 3 batches of 95% ethanol alternately to overflow means such as lifting manipulation, the total flavones extraction ratio that draws ethanol extraction high conclusion during than water extraction.This method is only to be index and definite with the total flavones, does not understand for the extraction of other composition in the raw material.
Chinese patent application numbers 931124700, publication number CN1096937A, " Chinese medicine health beverage ".Promptly the medicine juice made from Chinese medicines such as containing Flos Chrysanthemi is equipped with other compositions and makes beverage., be to wrap up it wherein, put into pot and add water and hot plate and form with three layers of white cotton crocus cloth to the Flos Chrysanthemi extracts active ingredients.Though this method is easy and simple to handle, be unfavorable for the extraction of total flavones in the Flos Chrysanthemi significantly.
The purpose of this invention is to provide a kind of process that is suitable for the extraction available composition of chrysanthemum flower of batch production production, for the production of Flos Chrysanthemi class health food provides foundation.
The present invention is achieved in that
1, ethanol extracts for the first time: adopt existing extractive technique, under heating condition Flos Chrysanthemi overflow and carry.Earlier the extra dry white wine Flos Chrysanthemi powder is broken to 1/4 petal size, again by flower: alcohol=1: 30 preimpregnation Flos Chrysanthemi.Preimpregnation is identical with concentration of ethanol with ethanol and when extracting.General its concentration range is at 25%-95%.The pre-12h that overflows.Behind pre-casual the end, pre-flood irrigation is heated up, temperature is controlled at 50 ℃-70 ℃, and time dimension is held in 3-3.5h.Total flavones extraction ratio 74.24%.
2, ethanol extracts for the second time: the feed liquid that will extract is for the first time carried out melt cinder and is separated.Extracting solution after the separation is squeezed into pump and is store in the liquid filling, and residue under same heating condition, extracts 0.5h by the ethanol that adds same concentrations at 1: 15 again, after extraction finishes, carries out the melt cinder separation, merges filtrate twice.Total flavones extraction rate reached 87.15%.
3, water extraction: after the said extracted, residue added distilled water by 1: 15 and boil 20min under normal pressure, separated then, and was the detection index with the amino nitrogen.The amino nitrogen extraction ratio is 59.63%.
4, merging filtrate: after three extracting solution merging, stir, filter, obtain clarifying extracting solution.
5, concentrating under reduced pressure: with said extracted liquid (450mmHg) under reduced pressure, keep 50 ℃-55 ℃ of temperature, reclaim organic solvent, get concentrated extracting solution, this concentrated solution can be preserved 10 months no denaturalization phenomenons and produce after sterilization, fill.Can be used as the mother solution of various Flos Chrysanthemi health foods.
Advantage of the present invention and good effect:
1, the present invention adopts ethanol and water extraction, helps the effective ingredient total flavones in the Flos Chrysanthemi and water soluble ingredient such as amino nitrogen are extracted.
2, the present invention adopts the method for preimpregnation and heating extraction, has saved the time greatly, and equipment is accelerated turnover period, has therefore accelerated the cycle of producing.
3, the present invention utilizes ethanol extraction Flos Chrysanthemi gained extracting solution, and it is deposited and is difficult for going mouldy, and extracting liquid filtering and solvent recovery are easy to carry out.
4, easy to use: the concentrated solution in this method only is 1/3 of a former extracting solution, for depositing and transport the condition of facilitating.Medium and small producer can directly buy this concentrated solution and produce various Flos Chrysanthemi health foods.
Embodiments of the invention:
1, the dried piece of 0.2kg Flos Chrysanthemi is smashed to 1/4 petal with pulverizer, placed to extract and irritate, to the ethanol that wherein adds 6000ml 55%-75%, the pre-12h that overflows under the room temperature; To extract to irritate and heat to 60 ℃, and keep 3h, and separate melt cinder then, extracting solution is gone into to store liquid and is irritated preservation.
2, add 3000ml same concentrations ethanol again to extracting to irritate in the residue, extract 0.5h again under 60 ℃, separate melt cinder, merge filtrate twice, the total flavones extraction ratio can reach more than 85% in this extracting solution.
3, add the 3000ml distilled water in residue behind the secondary ethanol extraction, boil 20min under normal pressure, separate then, the amino nitrogen extraction ratio is more than 50%.
4, with after three extracting solution merging, fully stir 15min, leave standstill after-filtration, must clarify extracting solution.
5, above-mentioned trip's liquid concentrating under reduced pressure under 55 ℃ of conditions is removed ethanol, gets concentrated extracting solution.This extracting solution can be used for various Flos Chrysanthemi health care food production.
Claims (4)
1, a kind of method with ethanol and water extraction available composition of chrysanthemum flower is characterized in that extracting stock solution behind merging, filtration, concentrating under reduced pressure with ethanol and moisture step heating extraction, obtains concentrated solution.
2,, it is characterized in that branch two step carries out according to the described ethanol extraction of claim 1.The first step, Flos Chrysanthemi and ethanol solid-liquid ratio are 1: 30, and concentration of alcohol is preferably in 55%-75%, and reheat overflows and carries behind the room temperature preimpregnation 1Zh, and temperature is at 50-70 ℃, and the time is 3-3.5h; In second step, solid-liquid ratio is 1: 15, and concentration of alcohol and heating-up temperature are respectively 55%-75% and 50-70 ℃, time 20min-0.5h.
3, according to the described water extraction of using of claim 1, it is characterized in that carrying out after ethanol extracts for the second time, solid-liquid ratio 1: 15 boils 20min.
4, according to claim 1,2,3 described extracting method, it is characterized in that three extracting solution mix after, carry out filtration treatment, and under 80 ℃ of-85 ℃ of conditions decompression recycling ethanol, finish leaching process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95117457 CN1150027A (en) | 1995-11-15 | 1995-11-15 | Method for extracting available composition of chrysanthemum flower |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95117457 CN1150027A (en) | 1995-11-15 | 1995-11-15 | Method for extracting available composition of chrysanthemum flower |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1150027A true CN1150027A (en) | 1997-05-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95117457 Pending CN1150027A (en) | 1995-11-15 | 1995-11-15 | Method for extracting available composition of chrysanthemum flower |
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| CN (1) | CN1150027A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304018C (en) * | 2003-07-29 | 2007-03-14 | 天津宝洁生物制品有限公司 | Cough-stopping throat-clearing medicament made from chrysanthemum flower |
| CN102188469A (en) * | 2011-05-27 | 2011-09-21 | 河南大学 | Chrysanthemum morifolium extractive with live protection function, extraction method and applications thereof |
| CN102669679A (en) * | 2012-05-11 | 2012-09-19 | 广东汇香源生物科技股份有限公司 | Method for preparing chrysanthemum morifolium ramat extract in microwave-assisted way |
| CN102973628A (en) * | 2012-12-04 | 2013-03-20 | 安徽菊泰滁菊草本科技有限公司 | Chuzhou chrysanthemum general flavone grains as well as preparation method and application thereof |
| CN104490968A (en) * | 2014-12-08 | 2015-04-08 | 张旭 | Extracting method of chamomile extract |
| CN111789877A (en) * | 2019-04-09 | 2020-10-20 | 会昌实业股份有限公司 | Method for extracting total flavonoids from Fructus Chrysanthemum and method for preparing preparation for improving dry eye |
-
1995
- 1995-11-15 CN CN 95117457 patent/CN1150027A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304018C (en) * | 2003-07-29 | 2007-03-14 | 天津宝洁生物制品有限公司 | Cough-stopping throat-clearing medicament made from chrysanthemum flower |
| CN102188469A (en) * | 2011-05-27 | 2011-09-21 | 河南大学 | Chrysanthemum morifolium extractive with live protection function, extraction method and applications thereof |
| CN102669679A (en) * | 2012-05-11 | 2012-09-19 | 广东汇香源生物科技股份有限公司 | Method for preparing chrysanthemum morifolium ramat extract in microwave-assisted way |
| CN102973628A (en) * | 2012-12-04 | 2013-03-20 | 安徽菊泰滁菊草本科技有限公司 | Chuzhou chrysanthemum general flavone grains as well as preparation method and application thereof |
| CN102973628B (en) * | 2012-12-04 | 2014-10-08 | 安徽菊泰滁菊草本科技有限公司 | Chuzhou chrysanthemum general flavone grains as well as preparation method and application thereof |
| CN104490968A (en) * | 2014-12-08 | 2015-04-08 | 张旭 | Extracting method of chamomile extract |
| CN111789877A (en) * | 2019-04-09 | 2020-10-20 | 会昌实业股份有限公司 | Method for extracting total flavonoids from Fructus Chrysanthemum and method for preparing preparation for improving dry eye |
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