CN114949092A - Traditional Chinese medicine ointment and plaster for treating rheumatic ostealgia and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine ointment, a patch for treating rheumatic bone pain and a preparation method thereof. In the present invention, the process of mixing S. vulgaris, five-flowered seven, Angelica dahurica, silkworm, raw Pinellia, tulsi, nocturnal vine, copper bone seven, dog ridge and salt, soaking in water, repeating the boiling and extracting process for several times, Concentrating the obtained extract into a thick substance with a relative density of 1.0 to 1.2 at 60° C.; adding mugwort velvet to the thick substance, stirring evenly at 2000 rpm/min to obtain a thick substance; mixing frankincense and talcum powder, Under stirring, heat and melt at 100°C to 130°C to obtain a melt, add the thick substance and fry for 10 to 15 minutes to obtain a paste-like ointment, which is coated on a non-woven fabric to obtain a paste. The ointment and plaster of the present invention can play a good therapeutic effect and preventive effect without affecting the normal life of the patient, and the medicinal property is relatively mild, and will not cause skin allergy, redness, itching and other problems.

Description

A kind of traditional Chinese medicine ointment, patch for treating rheumatism and bone pain and preparation method thereof

technical field

The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine ointment, a patch for treating rheumatic bone pain and a preparation method thereof.

Background technique

Rheumatic arthritis is a common acute or chronic inflammation of connective tissue. Commonly referred to as rheumatoid arthritis is one of the main manifestations of rheumatic fever, clinically characterized by migratory soreness, redness, and pain in joints and muscles. It is related to group A beta-hemolytic streptococcus infection, and factors such as cold and humidity can induce the disease. Large joints of the lower extremities such as knees and ankles are most commonly affected.

Joint pain is the primary symptom of rheumatoid arthritis. Pain may occur in joints all over the body, but it is more common to involve large joints, such as knee joints, ankle joints, shoulder joints, and wrist joints. The typical presentation is symmetrical, migratory pain accompanied by inflammatory manifestations of redness, swelling, and heat. Usually, the symptoms of acute inflammation subside for 2 to 4 weeks, and the symptoms of the disease are characterized by the subsidence of symptoms in one joint and the reappearance of symptoms in another joint. In addition, rheumatoid arthritis is greatly affected by climate change, and joint pain often occurs before the weather turns cold or it rains.

The plaster for the treatment of rheumatoid arthritis in the prior art is generally manifested as:

(1) It is highly irritating to apply sticking treatment to the lesion site, and local redness, swelling, itching and even ulceration may occur after a long sticking time; , causing itching and swelling of the skin;

(2) From a practical clinical point of view, the existing drugs can only temporarily play a therapeutic effect, and the therapeutic drugs that claim to be able to cure or not recur are in fact exaggerated and cannot solve the problem of recurrent rheumatoid arthritis. The problem is that few drugs can solve the problem from the perspective of treatment combined with prevention and it recurs.

SUMMARY OF THE INVENTION

The primary purpose of the present invention is to provide a traditional Chinese medicine ointment for treating rheumatic bone pain.

Another object of the present invention is to provide a method for preparing the above-mentioned traditional Chinese medicine ointment.

Another object of the present invention is to provide a patch prepared from the above-mentioned traditional Chinese medicine ointment.

The present invention is achieved in this way, a preparation method of a traditional Chinese medicine ointment for the treatment of rheumatic bone pain, the method comprises the following steps:

(1) Mix 100-120 parts by mass of Spermone, 80-100 parts by mass of five flowers, 40-50 parts by mass of Angelica dahurica, 40-50 parts by mass of silkworm, 40-50 parts by mass of raw Pinellia sinensis, and 20-30 parts by mass of 20-30 parts by mass of C. japonica, 10-20 parts by mass of Tonggu seven, 10-20 parts by mass of dog ridge, and 2-4 parts by mass of table salt, add water to soak, repeat the process of boiling and extraction several times, Concentrating the obtained extract into a thick substance with a relative density of 1.0-1.2 at 60°C;

(2) adding 40～60 parts by mass of wormwood to the thick substance, stirring evenly at 2000rpm/min to obtain the thick substance;

(3) mixing 5-6 parts by mass of frankincense and 20-30 parts by mass of talc powder, under stirring, heating and melting at 100°C～130°C to obtain a melt, adding the thick substance and frying for 10～15min to obtain a paste ointment.

Preferably, in the step (1), 110 parts by mass of Radix peregrine, 90 parts by mass of five flowers seven, 45 parts by mass of Angelica dahurica, 45 parts by mass of silkworm, 45 parts by mass of unripe Pinellia, 25 parts by mass of interrupted, 25 parts by mass of Parts by mass of Corydalis chinensis, 15 parts by mass of Tonggu seven, 15 parts by mass of dog ridges, and 3 parts by mass of table salt were mixed.

Preferably, in step (2), 50 parts by mass of mugwort velvet is added to the thick substance.

Preferably, in step (3), 4 parts by mass of frankincense and 2.5 parts by mass of talc are mixed.

Preferably, in step (3), the paste-like ointment 3 is dried and pulverized to 200-300 mesh, added to 60-100 parts by mass of ethanol, stirred evenly, sealed and stored to obtain a paste-like ointment.

The invention further discloses the traditional Chinese medicine ointment obtained by the preparation method.

The invention further discloses a traditional Chinese medicine plaster for treating rheumatic bone pain. The traditional Chinese medicine plaster includes a base material layer, the center position of one side of the base material layer is coated with the above-mentioned traditional Chinese medicine ointment, and the outer edge of the center position is coated with a base material layer. Adhesive that temporarily assists sticking on the surface of human skin.

Preferably, the substrate is a non-woven fabric.

The present invention overcomes the deficiencies of the prior art, and provides a traditional Chinese medicine ointment, a patch for treating rheumatic bone pain and a preparation method thereof. In the field of traditional Chinese medicine, there are many traditional Chinese medicines that can dispel dampness and relieve pain. However, the efficacy of each traditional Chinese medicine is reflected in many aspects. The selection and compatibility of drugs and the preparation process play a decisive role in stimulating the desired efficacy. effect. On the basis of very clinical experience, the present invention starts with various commonly used Chinese medicinal materials, and on the basis of continuous screening, replacement, and repeated verification, selects the combination of Tougucao and Wuhuaqi as the monarch medicine. When applying for treatment, it can overcome the mutual stimulation of the effects of removing dampness, relieving pain, promoting blood circulation and dredging collaterals in the case of non-tang The opening of the hole promotes the dissolution and precipitation of the drug, and plays a major role in the formation of the thick substance of the ointment. It plays the role of fibrous skeleton and ventilation and blood circulation. Frankincense and talcum powder in the ointment not only play a role in promoting the curative effect, but also can form uniform chapped fine lines in the ointment layer after the surface layer of the ointment is dried, and dissipate heat in the ointment layer. , sweat absorption, stomata patency played the role of traditional Chinese medicine. The effect of edible salt (sodium chloride) can not only reduce inflammation and sterilization, but also can promote blood circulation, and should be combined with wormwood, frankincense crystal particles, and talc after cooling and recrystallization. The solidified ointment layer plays an important role in dissolving the drug components, forming a film layer channel, absorbing sweat and expelling the skin to keep the skin dry.

The ointment of the present invention can be directly applied to the joint site of the disease for the purpose of treatment, and can also be applied to the skin surface before the disease is present for the purpose of preventing the disease. It can be well pasted on the skin at human body temperature, and a non-sticky film can be formed on the outside at room temperature, or talc powder can be applied to eliminate stickiness when the room temperature is higher.

In addition, the ointment of the present invention can also be directly made into the form of a plaster, the traditional Chinese medicine plaster comprises a base material layer of non-woven material, the center position of one side of the base material layer is coated with the above-mentioned traditional Chinese medicine ointment, and the center position of the traditional Chinese medicine ointment is coated. The outer edge is coated with adhesive temporarily to assist in sticking on the surface of human skin. The traditional Chinese medicine plaster is directly applied to the joint site of the disease for the purpose of treatment, and it can also be applied to the surface of the skin before the disease is present for the purpose of preventing the disease. The ointment forms a flexible patch on the skin surface.

Compared with the shortcomings and deficiencies of the prior art, the present invention has the following beneficial effects:

(1) ointment and plaster of the present invention can play good therapeutic effect and preventive effect;

(2) ointment and plaster of the present invention are relatively mild in nature, do not promote the passive absorption of the active ingredient of the medicine by the skin through irritating drugs, and do not cause problems such as tingling, redness and swelling;

(3) The film layer formed on the skin surface of the ointment of the present invention has good air permeability and heat dissipation, and will not cause problems such as skin itching; and the film layer has good wear resistance, and the film layer is flexible and can be very Good fit to the surface of human skin, free from shedding problems caused by changes in skin surface morphology during exercise;

(4) The ointment of the present invention can effectively promote the continuous precipitation of the active ingredients of the medicine under the state of body temperature and sweat melting.

Detailed ways

In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

Example 1

(1) 100 parts by mass of Siberia vulgaris, 80 parts by mass of five flowers seven, 40 parts by mass of Angelica dahurica, 40 parts by mass of dead silkworm, 40 parts by mass of unripe Pinellia sinensis, 20 parts by mass of succulent, 20 parts by mass of night vine, 10 parts by mass of Mass parts of copper bone seven, 10 mass parts of dog ridge, and 4 mass parts of salt are mixed, soaked in water, repeated boiling and extraction process several times, and the obtained extract is concentrated into a thick substance with a relative density of 1.0 to 1.2 at 60 ° C;

(2) adding 40 parts by mass of wormwood to the thick substance, stirring at 2000 rpm/min to obtain the thick substance;

(3) 5 parts by mass of frankincense and 2 parts by mass of talc were mixed, heated and melted at 130° C. under stirring to obtain a melt, and 100 parts by mass of the thick substance was added and fried for 15 minutes to obtain a paste-like ointment 1.

Example 2

(1) 120 parts by mass of Syringa, 100 parts by mass of Five Flowers Seven, 50 parts by mass of Angelica dahurica, 50 parts by mass of Silkworm, 50 parts by mass of unripe Pinellia ternata, 30 parts by mass of Interrupted, 30 parts by mass of Nocturne vine, 20 parts by mass of Mass parts of copper bone seven, 20 mass parts of dog ridge, and 2 mass parts of salt are mixed, soaked in water, repeated boiling and extraction process several times, and the obtained extract is concentrated into a thick substance with a relative density of 1.0 to 1.2 at 60 ° C;

(2) 60 parts by mass of wormwood velvet were added to the thick substance, and stirred at 2000 rpm/min to obtain the thick substance;

(3) Mix 6 parts by mass of frankincense and 3 parts by mass of talc, and under stirring, heat and melt at 100° C. to obtain a melt, add 100 parts by mass of the thick substance, and stir-fry for 10 minutes to obtain a paste-like ointment 2 .

Example 3

(1) 110 parts by mass of Siberia vulgaris, 90 parts by mass of five flowers seven, 45 parts by mass of Angelica dahurica, 45 parts by mass of silkworm, 45 parts by mass of unripe Pinellia sinensis, 25 parts by mass of interrupted, 25 parts of Mass parts of copper bone seven, 15 mass parts of dog ridge, and 3 mass parts of salt are mixed, soaked in water, repeated boiling and extraction process several times, and the obtained extract is concentrated into a thick substance with a relative density of 1.0 to 1.2 at 60 ° C;

(2) adding 50 parts by mass of wormwood to the thick substance, stirring at 2000 rpm/min to obtain the thick substance;

(3) 5.5 parts by mass of frankincense and 2.5 parts by mass of talc were mixed, heated and melted at 120° C. under stirring to obtain a melt, and 100 parts by mass of the thick substance was added and fried for 12 minutes to obtain a paste-like ointment 3 .

Example 4

This Example 4 is basically the same as Example 3, the difference is that in step (3), the paste-like ointment 3 is dried and pulverized to 200-300 mesh, added to 100 parts by mass of ethanol, stirred evenly, and sealed for storage. Get the creamy ointment 4.

Example 5

This Example 5 is basically the same as Example 3, the difference is that in step (3), the paste-like ointment 3 is dried and pulverized to 200-300 mesh, added to 60 parts by mass of ethanol, stirred evenly, and sealed for storage. Get the creamy ointment 5.

Example 6

Apply the ointment 3 prepared in the above embodiment to the center of the non-woven fabric by using a roller, and coat the outer edge of the center position with adhesive to obtain the traditional Chinese medicine plaster 1 .

Example 7

The ointment 5 prepared in the above embodiment is applied to the center of the non-woven fabric by a roller, and glue is applied to the outer edge of the center position to obtain a traditional Chinese medicine plaster 2. After sticking a plastic film, it is bagged and sealed, and stored in a cool place.

Comparative Example 1

This comparative example 1 is basically the same as that of Example 3, the difference is that in step (1), the five flowers seven are not added, and finally a paste-like ointment 6 is obtained.

Comparative Example 2

This Comparative Example 1 is basically the same as Example 3, the difference is that in step (1), no silkworm and raw Pinellia are added, and a paste-like ointment 7 is finally obtained.

Comparative Example 3

This Comparative Example 1 is basically the same as Example 3, the difference is that in step (1), no tick, Nocturne, Tonggu seven, and dog ridge are not added, and finally a paste-like ointment 8 is obtained.

Comparative Example 4

This Comparative Example 1 is basically the same as Example 3, the difference is that no salt is added in step (1), and a paste-like ointment 9 is finally obtained.

Comparative Example 5

This Comparative Example 1 is basically the same as Example 3, except that step (3) is omitted, and the thick substance obtained in step (2) is identified as ointment 10.

Effect Example 1

This effect embodiment is tested for the relevant physical properties of the ointment prepared in the above-mentioned embodiment, and the test content includes the following aspects:

(1) Adhesion

Coat the ointment on the surface of human skin with a thickness of 1 to 2 mm. After natural drying or hot air drying, peel it off through the nails. If it peels off in flakes, cracks and falls off, it indicates poor adhesion; otherwise, it indicates stickiness. Good attachment.

(2) Film-forming properties

Coat the ointment on the surface of human skin with a coating thickness of 1-2mm. After natural drying or hot air drying, visually observe whether the coating layer forms a film layer and whether there are fine cracks on the film layer.

(3) flexibility

Coat the ointment on the skin surface of the knee joint (meniscus) of the human body, and the coating thickness is between 1 and 2 mm. After natural drying or hot air drying, the human body performs squatting and standing movements for 10 minutes, 10 times/min, and the film is observed with the naked eye. Whether the layer is peeled off or cracked, if so, it indicates that the flexibility is poor, if not, it indicates that the flexibility is good.

(4) Wear resistance

Coat the ointment on the surface of human skin with a coating thickness of 1 to 2mm. After natural drying or hot air drying, wrap the non-woven fabric on the rotor. When the rotor rotates at 30 rpm/min, the non-woven The free end of the cloth is in contact with the film layer, and the wear of the film layer is detected after 30 minutes. If the film layer is not damaged, cracked or rolled up, it indicates that the wear resistance is good, otherwise it is poor.

(5) Water-soluble

Take a small amount of ointment and apply it to the surface of the dry and smooth substrate. The coating thickness is between 1 and 2 mm and the area is about 6 cm × 8 cm. After drying to form a film, keep the surface of the film in a moist state, and heat the surface of the film to 36°C to 37°C. ℃, after 30 to 40 minutes, touch the skin with the fingertips to check whether the film can be lifted smoothly and kept from falling within 10S. If so, it indicates that the water solubility is good, otherwise it is poor.

(6) Breathability

Coat the ointment on the non-woven fabric with a coating thickness of 1-2 mm. After drying to form a film, wrap the non-woven fabric on the air suction cylinder. The wrapping position is well sealed and there is no air leakage. Pull the piston to make the air suction needle. Keep the negative pressure in the cylinder, keep the position of the piston stationary for 5-8 minutes, release the force applied to the piston, and detect the return of the piston to detect the air permeability of the air from the non-woven film layer. If the piston does not move in place or the displacement is small, it indicates that the air permeability of the membrane layer is good. If the piston returns more than 1/3, it indicates that the air permeability of the membrane layer is not good.

(7) irritating

Take 20 people (adults) as a group, apply the ointment on the surface of human skin with a thickness of 1 to 2 mm, and check whether the skin has itching, stinging, redness, allergies and other adverse conditions within 3 days after application. If the statistical rate of adverse conditions is between 5% and 10%, it means that the irritation is general, if it exceeds 10%, it is highly irritating, and if it is less than 5%, it means that it is not irritating.

Select the ointment prepared in the above-described embodiment to carry out the performance detection of the above items, and the results are as shown in Table 1 below:

Table 1 Performance test results

In Table 1, the adhesion index is reflected in the degree of adhesion to the skin surface after film formation, more in the overall structure formed with the epidermis and hair on the skin surface after film formation, and the water solubility is reflected in the dissolution rate of the drug.

As can be seen from the above table 1, the compatibility of each component in the ointment of the present invention has played a very important role in the physical properties of the product, not only in the function of a certain component, but also in the formation of the composition after the components are matched. on the collaborative function. The ointment 7 has the problems of poor adhesion, poor flexibility, and poor wear resistance, and is prone to breakage, falling off, and cracking in practical applications. The ointment 8 has the problems of poor flexibility and poor wear resistance. Airtight, airtight is the biggest cause of its irritation; ointment 10 has problems of poor adhesion, poor flexibility, and poor wear resistance. Obviously, the results of ointment 8 and ointment 10 can be inferred that frankincense, stiffness The compatibility relationship between silkworm and raw Pinellia plays an important role in adhesion, flexibility and wear resistance. The compatibility relationship between salt, frankincense and talcum powder has a significant causal relationship for water solubility.

Effect Example 2

1. Therapeutic effect

1. How to use

Coat the ointment on the skin surface of the affected joint of the human body, the coating thickness is between 1 and 2mm, and dry it naturally, dry it with hot air or apply talcum powder on the surface for de-sticking treatment.

After the plaster is applied to the skin surface of the affected joint of the human body for 1-2 hours, the non-woven fabric of the plaster is torn off, and the ointment layer on the non-woven fabric is pasted on the skin.

Three months is a course of treatment, with six doses in each course: Day 1, Day 3, Day 7, Day 15, Day 30, Day 45, Day 60, Day 90.

2. Efficacy evaluation standard

Cure: take medicine until the patient's pain symptoms disappear, that is, cure;

Improvement: The main symptoms disappeared, the pain and discomfort disappeared obviously, but mild symptoms still appeared;

Invalid: no significant change in symptoms and characteristics.

3. Treatment object and symptom statistics

The present invention treats a total of more than 40 patients, aged between 30 and 70 years old, whose symptoms are mainly manifested in rheumatoid arthritis of the knee joint, bone hyperplasia, deformation and related complications, including pain, dizziness, chest tightness and the like. In actual clinical experiment, the present invention selects ointment 3, ointment 4, ointment 6 and traditional Chinese medicine patch 2 to carry out treatment experiment respectively, and statistical result is as shown in table 2 below:

4. Introduction of typical clinical cases

(1) Zhong Moumei, 55 years old, female, suffering from rheumatic bone disease for nearly 8 years, toe crystal deformation, using ointment 3 according to the course of treatment, the heat sensation is obvious 2 to 3 hours after each medication, and the work and life are not affected after the medication , There is no problem of redness, swelling, tingling, itching and itching in the place where the plaster is applied. You can take a normal bath. When changing the dressing, apply an alcohol tissue to wipe it off. During the course of treatment, the pain is gradually relieved and finally disappeared, achieving the effect of clinical cure.

(2) Chen Mouxing, 54 years old, male, family inherited gout, gout caused by long-term drinking, mild pain, used ointment 6 according to the course of treatment, the symptoms did not improve significantly after the third medication, after the fourth medication, the patch 2 was used , the pain gradually relieved after two doses and finally disappeared.

(3) Jiang Mouping, 61 years old, male, with rheumatoid arthritis and bone hyperplasia, was treated with Patch 2 according to the course of treatment, the pain disappeared obviously during the course of treatment, and he could work normally after the fourth treatment.

2. Prevention and control effect

Continuously track the condition of the treatment objects of ointment 3, ointment 4 and traditional Chinese medicine plaster 2. During the tracking period, use plaster 2 every month or before the rainy weather changes, and plaster 2 is attached to the primary disease site or other joints or related acupoints The disease of the parts (such as Mingmen, Huantiao, Yinmen, etc.) was tracked for one year, and the number of people who completed the disease tracking was 10. The statistical results of disease tracking showed that no patient's disease recurred or repeated within a year.

The above descriptions are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention shall be included in the protection of the present invention. within the range.

Claims (8)

1. a preparation method of the traditional Chinese medicine ointment for the treatment of rheumatic bone pain, is characterized in that, the method comprises the following steps: (1) Mix 100-120 parts by mass of Spermone, 80-100 parts by mass of five flowers, 40-50 parts by mass of Angelica dahurica, 40-50 parts by mass of silkworm, 40-50 parts by mass of raw Pinellia sinensis, and 20-30 parts by mass of 20-30 parts by mass of C. japonica, 10-20 parts by mass of Tonggu seven, 10-20 parts by mass of dog ridge, and 2-4 parts by mass of table salt, add water to soak, repeat the boiling and extraction process several times, Concentrating the obtained extract into a thick substance with a relative density of 1.0-1.2 at 60°C; (2) adding 40～60 parts by mass of wormwood to the thick substance, stirring evenly at 2000rpm/min to obtain the thick substance; (3) mixing 5-6 parts by mass of frankincense and 2-3 parts by mass of talc powder, under stirring, heating and melting at 100 ℃～130 ℃ to obtain a melt, adding 100 parts by mass of the thick substance and frying for 10-15 min, Get a creamy ointment. 2. preparation method as claimed in claim 1, is characterized in that, in step (1), by 110 mass parts of Radix Radix, 90 mass parts of Five Flowers Seven, 45 mass parts of Angelica, 45 mass parts of silkworm, 45 mass parts of Parts by mass of raw Pinellia, 25 parts by mass of broccoli, 25 parts by mass of Nocturne vines, 15 parts by mass of Tonggu seven, 15 parts by mass of dog ridges, and 3 parts by mass of table salt are mixed. 3. The preparation method according to claim 2, characterized in that, in step (2), 50 parts by mass of mugwort velvet is added to the thick substance. 4. The preparation method of claim 1, wherein in step (3), 4 parts by mass of frankincense and 2 parts by mass of talc are mixed. 5. The preparation method according to claim 1, characterized in that, in step (4), the paste-like ointment 3 is dried and pulverized to 200-300 mesh, added to 60-100 parts by mass of ethanol, stirred evenly, Sealed and stored to obtain a creamy ointment. 6. The traditional Chinese medicine ointment obtained by the preparation method according to any one of claims 1 to 5. 7. A traditional Chinese medicine plaster for the treatment of rheumatic bone pain, it is characterized in that, this traditional Chinese medicine plaster comprises a base material layer, and the center position of one side of this base material layer is coated with the described Chinese medicine ointment of claim 5, and the center position The outer edge is coated with adhesive that temporarily assists in sticking on the surface of human skin. 8. The traditional Chinese medicine plaster of claim 7, wherein the base material is a non-woven fabric.