CN114948286B - Tooth appliance with caries preventing function and preparation method - Google Patents

Abstract

The application discloses a dental appliance with a caries prevention function and a preparation method thereof, wherein the components for preparing the silica gel dental appliance comprise A-component adhesive, B-component adhesive and fluoride which are combined according to a preset proportion. Namely, when the dental appliance is prepared, fluoride is added into raw materials for preparing the silica gel dental appliance, so that the prepared silica gel dental appliance contains fluoride, and when a user wears the dental appliance, the fluoride in the dental appliance is continuously released to the tooth surface through saliva in the oral cavity, so that the effect of preventing dental caries is achieved.

Description

Dental appliance with anti-caries function and preparation method thereof

technical field

The invention relates to the technical field of medical supplies, in particular to a dental appliance with an anti-caries function and a preparation method.

Background technique

Malocclusion is a common oral disease in children, which will affect the appearance, growth and development, chewing and language functions of children's maxillofacial area. Surveys show that the incidence of malocclusion among children in my country exceeds 60%. In the early stages of children's growth and development, timely and correct treatment and correction of possible and existing malocclusions is very necessary. However, because the wearing of the appliance will hinder the oral hygiene, children are very prone to dental caries during the orthodontic process. Studies have shown that the number of cariogenic bacteria increased significantly 6 months after the placement of fixed appliances in the oral cavity. Simultaneously, saliva flow rate and buffering capacity are also altered. When using the most common fixed appliance, 46.2% of patients developed chalky spots or worsened chalky spots 6 months after starting orthodontics; 20.2% of patients developed caries or worsened dental caries 6 months after starting orthodontics. Even with strict oral hygiene, patients are prone to caries during orthodontic treatment. However, when active appliances were used, the number of carious, missing, and filled teeth in children increased significantly (the caries became more serious), and the accumulation of plaque on the tongue side also increased.

In view of the above problems, the current solution is to apply a fluorine film formed by fluoride on the inner side of the dental appliance when making the appliance, so that when the user wears the appliance, fluoride ions pass through the saliva from the appliance. released from the fluoride membrane. However, since the fluorine film formed by the fluoride is in direct contact with saliva in the oral cavity, the fluoride is rapidly released in a short time. Therefore, the effect of sustained release of fluorine cannot be achieved. And because the fluoride ions are released from the fluoride film into the oral cavity within a short time, the concentration of fluoride ions in the oral cavity is higher than the safe concentration, which is harmful to human health.

Contents of the invention

This application provides a dental appliance with the function of preventing dental caries to solve the problem in the prior art that the rate of fluoride ion release from the fluoride film on the surface of the dental appliance is uncontrollable, and further solve the problem that the appliance cannot continuously release fluoride ions to prevent dental caries. The problem. The present application also provides a method for preparing a dental appliance with the function of preventing dental caries.

The present application provides a dental appliance with the function of preventing dental caries, comprising: the components of the silica gel used to prepare the dental appliance include A component glue, B component glue, and fluoride combined according to a predetermined ratio.

Optionally, the proportion of fluoride in the silica gel is in the following range: 0.01%≤fluoride≤15%, and the A-component glue and the B-component glue occupy the remaining proportion.

Optionally, the fluorine compounds include fluorine-containing organic or inorganic compounds.

Optionally, the ratio of the A-component glue and the B-component glue is determined according to preset requirements.

Optionally, the colloidal silica has micropores with different diameters opening on the contact surface between the appliance and the teeth, and the fluoride is released to the tooth surface through the micropores.

Optionally, the average diameter of the micropores with different diameters is obtained by adjusting the manufacturing process, wherein the adjusting the manufacturing process includes: adjusting the pressure during injection molding during the manufacturing process. Optionally, by making the micropores have different average diameters or different proportions of fluoride, dental appliances with different fluoride release rates can be obtained.

In addition, the present application provides a method for preparing a dental appliance with the function of preventing dental caries, including: step 1: material selection, according to a predetermined ratio, selecting component A glue and component B glue for synthesizing gum glue, and adding The fluoride of the synthetic silica gel; step 2: mixing, mixing the A component glue, the B component glue and the fluoride evenly; step 3: injection molding, injecting the mixed material into the mold; Step 4: Drying and shaping, drying and shaping the mold after injection molding; Step 5: Trimming, taking out the shaped dental appliance from the mold and performing post-shaping processing.

Optionally, the dental appliance enables the fluoride to have a predetermined release rate through at least one of the following methods:

adjusting the proportion of fluoride in the predetermined ratio;

In the injection molding step, the silica gel has different average pore diameters through the pressurization of different pressures, and the different average pore diameters cause the fluoride to have different release rates; by adjusting the pressurization pressure, thereby The average pore diameter is adjusted to obtain a predetermined release rate.

Optionally, by adjusting the predetermined ratio and the average micropore diameter, the fluoride has different release rates, so that the appliance has a caries-preventing function during treatment.

Compared with the prior art, the present application has the following advantages:

According to the dental appliance with anti-caries function of the present application, the components for preparing the silicone dental appliance include component A glue, component B glue, and fluoride combined according to a predetermined ratio. In the process of preparing a dental appliance with an anti-caries function, according to a predetermined ratio, select A-component glue and B-component glue for the synthetic gelatin dental appliance, and add fluoride to the synthetic silica gel; The A-component glue, the B-component glue and the fluoride are mixed uniformly; the mixed materials are injected into a mold; and the injection molded mold is dried and shaped. The manufactured silicone dental appliance contains fluoride, and when the user wears the dental appliance, the fluoride in the dental appliance is continuously released to the tooth surface through the saliva in the oral cavity, thereby achieving the effect of preventing dental caries.

Description of drawings

In order to facilitate the understanding of those skilled in the art, the present invention will be further described below in conjunction with the accompanying drawings.

Fig. 1 shows a schematic diagram of a dental appliance provided according to an embodiment of the present application.

Fig. 2 shows a graph showing the relationship between the concentration of fluoride in a deionized aqueous solution and time (day) in a dental appliance sample provided according to an embodiment of the present application.

Fig. 3 shows a flowchart of a method for preparing a dental appliance according to an embodiment of the present application.

Detailed ways

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the application. However, the present application can be implemented in many other ways different from those described here, and those skilled in the art can make similar promotions without violating the connotation of the present application. Therefore, the present application is not limited by the specific implementation disclosed below.

Please refer to Figure 1, which is a schematic diagram of a dental appliance with an anti-caries function provided by this application, and H1, H2, H3, and L1 in Figure 1 can have different size combinations to adapt to different patient needs . The components of the dental appliance include A-component glue, B-component glue, and fluoride combined according to a predetermined ratio. Specifically, select a predetermined proportion of fluoride and the A-component glue and B-component glue used for synthesizing silicone products into a mixing container, wherein the A-component glue and B-component glue in the mixture undergo a curing reaction to form silica gel products. And the fluoride in the mixture will not chemically react with the A-component glue and the B-component glue, therefore, the fluoride is mixed into the resulting mixture of the A-component glue and the B-component glue In silicone products. In addition, the A-component glue and the B-component glue are two fluid substances used for mixing to form silica gel. When the two are mixed, they can react in a short time to form a solidified silica gel state, which is convenient for molding; It is often used in the field of dentistry, and the specific component materials of the two have many possible implementations in this field; since they are not the focus of this application, they will not be introduced in detail here.

It should be noted that the silica gel has micropores with different diameters opening on the contact surface between the appliance and the teeth, and the fluoride is released to the tooth surface through the micropores. Specifically, the average diameter of the micropores with different diameters is obtained by adjusting the conditions in the preparation process, wherein the adjustment of the conditions in the preparation process includes: adjusting the pressure during injection molding during the preparation process The diameter of the pores in the appliance.

Specifically, mix the A-component glue, the B-component glue and the fluoride evenly. The fluoride is evenly distributed inside the mixture. At this time, the A-component glue in the mixture reacts with the B-component glue to form a silica gel product with a microporous structure inside, and because the fluorine The compound does not react with the A-component glue and the B-component glue, so the fluoride is just uniformly adsorbed into the micropores of the silica gel in a solid state, and because the fluoride in the dental appliance The proportion of fluoride is very small, therefore, the fluoride in the dental appliance will not affect the process of the chemical reaction between the A component glue and the B component to form a silicone product. During specific implementation, the ratio of the fluorides is determined according to product specification requirements. After the A-component glue, the B-component glue, and the fluoride are evenly mixed, inject the mixed material into the mold through a glue injection machine, and check whether there is Impurities or air bubbles, if any, remove the impurities or air bubbles. After the glue injection machine is finished injecting glue, apply different pressures to the mixed materials in the mold through the pressurizing equipment and keep the pressure until the silicone products in the mold are dried and shaped, so that through the above process to generate Silicone aligners have different pore diameters.

It should be noted that when the user wears the dental appliance, saliva will penetrate into the microporous structure of the silica gel, and the diameter of the micropores will affect the penetration speed of saliva, and the diameter of the micropores will also affect the microporous structure of the silica gel. The contact area between fluoride and saliva in the hole, it can be seen that the release rate of fluoride in the dental appliance is directly related to the diameter of the micropore. Therefore, in the process of preparing the dental appliance, the pressure applied by the pressure-applying device in the injection molding step can be adjusted, and then the micropore diameter of the prepared silicone appliance can be adjusted. According to experiments, the release rate of fluoride in the dental appliance is not only related to the diameter of the internal micropores of the silica gel, but also related to the content ratio of the fluoride in the appliance. The higher the proportion of the fluoride content, the faster the release rate of the fluoride, the lower the proportion of the content, the slower the release rate of the fluoride, and because the fluoride is contained in the dental appliance It is filled in the microporous structure of the silica gel in a solid state. Therefore, after the user wears the appliance, due to the continuous release of the fluoride, the fluoride content in the appliance will gradually decrease. Therefore, the release of fluoride in the appliance The speed will gradually decrease. Please refer to FIG. 2 for details. FIG. 2 shows a graph showing the relationship between the concentration of fluoride in the deionized water solution and the time (day) of the dental appliance sample. Specifically, prepare disc samples with a diameter of 10mm and a thickness of 2.5mm, and prepare 6 samples, soak each sample in 0.2ml deionized water at the same time, and change the sample to the next soaking solution at the same time every day , until 21 days, calculate the daily fluoride ion release (ppm/d) per unit area of each sample and plot the average value as a "time-fluoride ion concentration" curve. As shown in Figure 2, in the early stage of the user wearing the dental appliance, the prepared dental appliance releases fluoride ions. At this time, the high-speed released fluoride ions just react with the user's teeth to remineralize the user's teeth Therefore, at the initial stage of wearing, the high-speed release of fluoride ions in the dental appliance will not have adverse effects on the user's body. As the wearing time increases, the rate at which the dental appliance releases fluoride ions becomes lower and lower. At this time, the low-speed release of fluoride ions can replenish the lost fluoride ions in time, and can avoid the side effects of excessive fluoride. It should be noted that for each user's dental condition, it is necessary to wear a dental appliance with a corresponding predetermined release speed that matches the user's dental condition, and details will not be repeated here.

Based on the above situation, it can be seen that for each user's tooth condition, it is necessary to match the dental appliance with different release rates for the user, and the release rate of fluoride in the dental appliance can be adjusted in the following three ways.

(1) When the diameter of the micropore is constant, adjust the release ratio of fluoride in the dental appliance by adjusting the predetermined ratio of the fluoride selection material, so that the dental appliance has different release speed.

(2) When the predetermined ratio of the selected fluoride is constant, adjust the release rate of fluoride in the dental appliance by adjusting the diameter of the micropore, so that the dental appliance has different release rates during the correction. speed.

(3) Simultaneously adjusting the diameter of the micropores and the predetermined ratio of the fluoride material to adjust the release speed of the fluoride in the dental appliance during the orthodontic treatment.

It should be noted that the present invention can select an appropriate predetermined ratio and micropore diameter according to the tooth condition of each user who needs to correct the teeth, so that the dental appliance has different release rates of fluoride during the correction period, and then Have different anti-caries effects on the wearer's teeth. Specifically, in the early stage of the user wearing the dental appliance, the prepared dental appliance releases fluoride ions at a high speed. At this time, the concentration of fluoride ions in the oral cavity is kept in a relatively high range, just to remineralize the user's teeth. As the wearing time increases, the rate at which the appliance releases fluoride ions becomes lower and lower, and then in the later period of wearing, the fluoride released from the appliance can replenish the lost fluoride ions in time, and avoid Side effects of too much fluoride. Therefore, dental appliances with different predetermined ratios and pore diameters can be selected according to the user's tooth conditions to meet the requirements for preventing and controlling dental caries.

Preferably, the fluorides include fluorine-containing organic or inorganic compounds, for example, not limited to one or more of the following molecules: sodium fluoride, sodium monofluorophosphate, stannous fluoride, fluorosilicic acid, fluorine Sodium silicate, fluorophosphate, fluorosilane, etc.

Optionally, the ratio of the A-component glue and the B-component glue is determined according to preset requirements, specifically, in the predetermined ratio during the preparation of the dental appliance with anti-caries function The content of fluoride is determined according to the condition of the wearer's teeth. Specifically, the proportion of fluoride in the dental appliance is adjusted according to the diagnostic results of the wearer's teeth. For example, the proportion of fluoride content is in the following range: 0.01% ≤ fluoride ≤ 15%; the A-component glue and the B-component glue occupy the remaining proportion.

Optionally, in order to make the dental appliance have a good anti-caries treatment effect, the release rate is at least 24 hours or more.

Optionally, the A-component glue and the B-component glue respectively include the following combination: the ratio of the A-component glue to the B-component glue is equal to 1:1 or other ratios.

Corresponding to the above-mentioned dental appliance with an anti-caries function, the present application also provides a preparation method for a dental appliance with an anti-caries function. Please refer to FIG. 3 for details. What FIG. 3 shows is a flow chart of the preparation method of the dental appliance in this embodiment. The same parts of this embodiment as the above-mentioned dental appliance with an anti-caries function will not be repeated. Please refer to the above-mentioned The corresponding part of the dental appliance with anti-caries function. The present application provides a method for preparing a dental appliance with an anti-caries function, including:

Step 1: material selection, according to a predetermined ratio, select component A glue and component B glue for synthesizing the rubber, and add the fluoride to the synthetic silica gel. When the production is implemented, the fluoride includes Organic or inorganic compounds of fluorine, for example, but not limited to one or more of the following molecules: sodium fluoride, sodium monofluorophosphate, stannous fluoride, fluorosilicic acid, sodium fluorosilicate, fluorophosphate, fluorine Silane etc.

Step 2: Mix, mix the A-component glue, the B-component glue and the fluoride evenly. Under the premise that the A-component glue and the B-component glue in this step can fully react, make the The fluoride is evenly distributed inside the mixture. The specific mixing process is as follows: Stir for 20-45 seconds with a glue mixing stick, and then put it into a glue mixer. Set stirring parameters, for example, rotation speed: 1500-3000 rpm, time: 200-300 seconds. Start the glue mixing machine. After the glue mixing is completed, put it into the mixing container, stir it manually for 20-45 seconds, and pour the mixed silica gel into the glue injection equipment.

Step 3: Injection molding, inject the mixed material into the mold, and check whether there are impurities or air bubbles in the silicone during the injection process, and if there are, remove the impurities or air bubbles. After the glue injection machine has finished injecting glue, apply different pressures to the mixed materials in the mold through the pressurizing equipment and keep the pressure to proceed to the next step, so that the mixed materials will generate silica gel in the next reaction During the process, the resulting silica gel has different pore diameters.

Step 4: Drying and shaping. Dry and shape the mold after injection molding. Specifically, put the mold filled with glue into the drying oven. When drying, you can choose the appropriate temperature and time according to the specific situation. A possible parameter selection is : Set the drying and setting temperature to 50-250 degrees, and the drying and setting time to 10-60 minutes. Cool to room temperature after taking out the mold, disassemble the mold and take out the aligner.

Step 5: trimming, taking out the shaped appliance from the mold and performing post-molding processing.

Optionally, the dental appliance enables the fluoride to have a predetermined release rate through at least one of the following methods:

adjusting the proportion of fluoride in the predetermined ratio;

In the injection molding step, the silica gel has different average pore diameters through the pressurization of different pressures, and the different average pore diameters cause the fluoride to have different release rates; by adjusting the pressurization pressure, thereby The average pore diameter is adjusted to obtain a predetermined release rate.

Optionally, by adjusting the predetermined ratio and the average micropore diameter, the fluoride has different release rates, so that the appliance has a caries-preventing function during treatment.

Although the present invention is disclosed above with preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make possible changes and modifications without departing from the spirit and scope of the present invention. Therefore, the present invention The scope of protection should be based on the scope defined by the claims of the present invention.

Claims (9)

1. A dental appliance with an anti-caries function, characterized in that the components of the silica gel for preparing the dental appliance include A component glue, B component glue, and fluoride combined in a predetermined ratio; The silica gel has micropores with different diameters that are open on the contact surface of the dental appliance and the teeth, and the fluoride is adsorbed into the micropores of the silica gel in a solid state and released to the tooth surface through the micropores. 2. The dental appliance with anti-caries function according to claim 1, characterized in that the proportion of fluoride in the silica gel is in the following range: 0.01%≤fluoride≤15%; the component A glue , The B component glue occupies the remaining proportion. 3. The dental appliance with anti-caries function according to claim 1, characterized in that the fluoride comprises organic or inorganic compounds containing fluorine. 4. The dental appliance with anti-caries function according to claim 1, characterized in that, the ratio of the A-component glue and the B-component glue is determined according to preset requirements. 5. The dental appliance with anti-caries function according to claim 1, the average diameter of the micropores with different diameters is obtained by adjusting the preparation process, wherein the adjustment preparation process comprises: by adjusting the preparation process Pressure during injection molding. 6. The dental appliance with anti-caries function according to claim 2, characterized in that, by making the micropores have different average diameters or different proportions of fluoride, dental correction with different fluoride release speeds can be obtained device. 7. A method for preparing a dental appliance with an anti-caries function as claimed in claim 1, characterized in that: Step 1: material selection, according to a predetermined ratio, select A-component glue, B-component glue for synthetic silica gel, and fluoride added to the synthetic silica gel; Step 2: Mix, mix the A component glue, the B component glue and the fluoride evenly; Step 3: Injection molding, inject the mixed material into the mold; Step 4: drying and shaping, drying and shaping the mold after injection molding; Step 5: trimming, taking out the shaped appliance from the mold and performing post-molding processing. 8. The method for preparing a dental appliance with an anti-caries function according to claim 7, wherein the dental appliance enables the fluoride to have a predetermined release rate by at least one of the following methods: adjusting the proportion of fluoride in the predetermined ratio; In the injection molding step, the silica gel has different average pore diameters through the pressurization of different pressures, and the different average pore diameters cause the fluoride to have different release rates; by adjusting the pressurization pressure, thereby The average pore diameter is adjusted to obtain a predetermined release rate. 9. The preparation method of the dental appliance with anti-caries function according to claim 8, by adjusting the predetermined ratio and the average pore diameter, the fluoride has different release speeds, so that the appliance can be treated During the period, it has the function of preventing dental caries.