CN114903947A - Composition with acne removing effect and application thereof in preparation of medicines or skin care products - Google Patents
Composition with acne removing effect and application thereof in preparation of medicines or skin care products Download PDFInfo
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- CN114903947A CN114903947A CN202210523858.0A CN202210523858A CN114903947A CN 114903947 A CN114903947 A CN 114903947A CN 202210523858 A CN202210523858 A CN 202210523858A CN 114903947 A CN114903947 A CN 114903947A
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 54
- 206010000496 acne Diseases 0.000 title claims abstract description 54
- 230000000694 effects Effects 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000003814 drug Substances 0.000 title claims description 11
- 229940079593 drug Drugs 0.000 title description 8
- 229920002101 Chitin Polymers 0.000 claims abstract description 75
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 75
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 75
- 244000124209 Crocus sativus Species 0.000 claims abstract description 21
- 235000015655 Crocus sativus Nutrition 0.000 claims abstract description 21
- 239000000341 volatile oil Substances 0.000 claims abstract description 21
- 241000241413 Propolis Species 0.000 claims abstract description 19
- 229940069949 propolis Drugs 0.000 claims abstract description 19
- 239000002904 solvent Substances 0.000 claims abstract description 19
- 239000002562 thickening agent Substances 0.000 claims abstract description 11
- 241001122767 Theaceae Species 0.000 claims description 73
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 60
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 60
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 50
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims description 36
- 239000000543 intermediate Substances 0.000 claims description 36
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 33
- 238000001035 drying Methods 0.000 claims description 33
- 230000035484 reaction time Effects 0.000 claims description 27
- 238000005303 weighing Methods 0.000 claims description 26
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 25
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 22
- 229940080258 tetrasodium iminodisuccinate Drugs 0.000 claims description 20
- GYBINGQBXROMRS-UHFFFAOYSA-J tetrasodium;2-(1,2-dicarboxylatoethylamino)butanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC(C([O-])=O)NC(C([O-])=O)CC([O-])=O GYBINGQBXROMRS-UHFFFAOYSA-J 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 229910001868 water Inorganic materials 0.000 claims description 20
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims description 18
- 230000001804 emulsifying effect Effects 0.000 claims description 15
- 238000007710 freezing Methods 0.000 claims description 13
- 230000008014 freezing Effects 0.000 claims description 13
- 238000002390 rotary evaporation Methods 0.000 claims description 13
- WBJINCZRORDGAQ-UHFFFAOYSA-N ethyl formate Chemical compound CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims description 11
- 238000003760 magnetic stirring Methods 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000000967 suction filtration Methods 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 8
- 238000012545 processing Methods 0.000 claims description 7
- XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims 1
- 239000004248 saffron Substances 0.000 abstract description 8
- 235000013974 saffron Nutrition 0.000 abstract description 8
- 239000006071 cream Substances 0.000 abstract description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 244000269722 Thea sinensis Species 0.000 abstract 2
- 230000000052 comparative effect Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 208000032544 Cicatrix Diseases 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 230000037387 scars Effects 0.000 description 2
- 208000020154 Acnes Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002910 effect on acne Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a composition with an acne removing effect, which comprises the following components: 80-90 parts of a solvent; 0.1-0.15 part of thickening agent; 0.2-0.3 part of saffron crocus essential oil; 1-3 parts of modified tea polyphenol; 1-2 parts of modified chitin; 1-5 parts of propolis. The invention has the beneficial effects that: when the modified tea polyphenol, the modified chitin and the saffron essential oil are used simultaneously in the preparation process, the acne treatment cream has a good effect on both whelk and intractable acne, the skin of a volunteer using the acne treatment cream can recover very quickly in the 1 st week, the 6 th week and the 12 th week, the skin of the volunteer can be completely cured in the 16 th week without leaving acne marks, and all the volunteers do not relapse after tracking for 1 year, which shows that the acne treatment cream has a very excellent acne treatment effect.
Description
Technical Field
The invention relates to the field of medicines, and particularly relates to a composition with an acne removing effect and application thereof in preparation of medicines or skin care products.
Background
Acne is easy to appear in adolescence, and skin diseases such as intractable acne and the like sometimes appear in sub-health people, and with the improvement of living standard of human, personal image is more and more valued, a lot of acne removing medicines are available on the market at present, but some acne removing medicines are cured quickly, but scars are easy to leave; some patients can not be cured; some acne treatment medicines can be cured, but are easy to relapse, so that the research on the acne treatment medicine which is high in acne treatment efficiency, not easy to leave scars and not easy to relapse is very necessary.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a composition with an acne removing effect and application thereof in preparing medicines or skin care products.
A composition with acne removing effect comprises the following components:
80-90 parts of a solvent;
0.1-0.15 part of thickening agent;
0.2-0.3 part of saffron crocus essential oil;
1-3 parts of modified tea polyphenol;
1-2 parts of modified chitin;
1-5 parts of propolis.
The composition is used in the field of medicine, especially for removing acne.
Further, the modified tea polyphenol comprises the following components:
1-4 parts of tea polyphenol;
30-200 parts of acetic anhydride;
30-200 parts of ethyl acetate;
0.1-0.5 part of pyridine.
Further, the preparation method of the modified tea polyphenol comprises the following steps:
s1, weighing the tea polyphenol, the acetic anhydride and the pyridine according to the weight parts;
s2, adding tea polyphenol, acetic anhydride and pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 20-80 ℃, the reaction time is 1-4 hours, and after the reaction is finished, performing low-temperature rotary steaming on the solution, freezing and drying to obtain a modified tea polyphenol intermediate 1;
s3: and (4) adding all the modified tea polyphenol intermediate 1 prepared in the step (S2), ethyl acetate and pyridine in a certain weight ratio into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 20-80 ℃, the reaction time is 2-8h, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing, drying and drying to obtain the modified tea polyphenol.
Further, the modified chitin comprises the following components:
30-50 parts of chitin;
10-30 parts of tetrasodium iminodisuccinate;
3-5 parts of ammonium persulfate;
200 portions of water and 1000 portions of water;
10-30 parts of sodium hydroxide;
30-100 parts of isopropanol;
3-8 parts of bromoacetic acid.
Further, the preparation method of the modified chitin comprises the following steps:
s1, weighing chitin, sodium hydroxide and tetrasodium iminodisuccinate according to the weight parts;
s2, adding tetrasodium iminodisuccinate and sodium hydroxide into water under a magnetic stirring state, dissolving, then adding chitin and ammonium persulfate into the solution, stirring uniformly, adding into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 15-50 ℃, the reaction time is 3-72h, and performing suction filtration and drying to obtain a modified chitin intermediate 1;
and S3, adding all the modified chitin intermediate 1 in the step S2, and isopropanol and bromoacetic acid in a certain mass ratio into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 20-80 ℃, and the reaction time is 1-6 hours, so as to obtain the modified chitin.
The preparation process of the composition with acne removing effect comprises the following steps:
s1, weighing the tea polyphenol, the acetic anhydride and the pyridine according to the weight parts; adding tea polyphenol, acetic anhydride and pyridine into a reaction kettle, setting reaction conditions, and drying the solution after the reaction is finished to obtain a modified tea polyphenol intermediate 1; adding all prepared modified tea polyphenol intermediates, ethyl acetate and residual pyridine in a certain weight ratio into a reaction kettle, setting reaction conditions, and drying the solution after the reaction is finished to obtain modified tea polyphenol;
s2, weighing chitin, ammonium persulfate, sodium hydroxide, water and tetrasodium iminodisuccinate according to the weight parts; adding tetrasodium iminodisuccinate and sodium hydroxide into water under the magnetic stirring state, dissolving, then adding chitin and ammonium persulfate into the solution, stirring uniformly and adding into a reaction kettle, setting reaction conditions, carrying out suction filtration and drying to obtain a modified chitin intermediate 1, adding all prepared chitin intermediate 1, isopropanol and bromoacetic acid in a certain mass ratio into the reaction kettle, and setting the reaction conditions to obtain the modified chitin;
s3: weighing a solvent, saffron crocus essential oil, modified tea polyphenol, modified chitin and propolis according to parts by weight, putting the solvent, the saffron crocus essential oil, the modified tea polyphenol, the modified chitin and the propolis into an emulsifying machine, and setting emulsifier parameters to obtain a solution 1; and then putting the solution 1 and the thickening agent into a jacket dissolving pot, setting reaction conditions, and cooling to obtain the composition with the acne removing effect.
The invention has the beneficial effects that: when the modified tea polyphenol, the modified chitin and the saffron essential oil are simultaneously used, the acne removing cream has a good effect on both whelks and intractable acnes, the skin of the volunteers using the acne removing cream is quickly recovered in the 1 st week, the 6 th week and the 12 th week, the skin of the volunteers is completely cured in the 16 th week without leaving acne marks, and all the volunteers do not relapse after tracking for 1 year, so that the acne removing cream is very excellent in acne removing effect.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below with reference to specific embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to clearly illustrate the technical features of the present solution, the present solution is explained below by way of specific embodiments.
Example 1:
s1, weighing 3 parts of tea polyphenol, 100 parts of acetic anhydride and 0.3 part of pyridine according to parts by weight; adding tea polyphenol, acetic anhydride and 0.1 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 50 ℃, the reaction time is 3 hours, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing and drying to obtain a modified tea polyphenol intermediate 1; and adding all prepared modified tea polyphenol intermediates, 100 parts of ethyl acetate and 0.2 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 60 ℃, the reaction time is 5 hours, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing, drying and drying to obtain the modified tea polyphenol.
S2, weighing 40 parts of chitin, 4 parts of ammonium persulfate, 20 parts of sodium hydroxide, 700 parts of water and 20 parts of tetrasodium iminodisuccinate according to parts by weight; adding tetrasodium iminodisuccinate and sodium hydroxide into water under the magnetic stirring state, dissolving, then adding chitin and ammonium persulfate into the solution, stirring uniformly, adding into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 40 ℃, the reaction time is 36 hours, performing suction filtration and drying to obtain a modified chitin intermediate 1, adding all prepared chitin intermediate 1, 80 parts of isopropanol and 6 parts of bromoacetic acid into the reaction kettle, wherein the internal environment temperature of the reaction kettle is 60 ℃, and the reaction time is 4 hours to obtain the modified chitin.
S3: weighing 85 parts of solvent, 0.25 part of saffron essential oil, 2 parts of modified tea polyphenol, 1.5 parts of modified chitin and 2 parts of propolis according to the parts by weight, and putting the solvent, the saffron crocus essential oil, the modified tea polyphenol, the modified chitin and the propolis into an emulsifying machine, wherein the rotating speed of the emulsifying machine is 1000r/min, and the processing time is 1h to obtain a solution 1; and then putting the solution 1 and 0.12 part of thickening agent into a jacket dissolving pot, treating at 90 ℃ for 30min, and cooling to obtain the composition with the acne removing effect.
Example 2:
s1, weighing 1 part of tea polyphenol, 30 parts of acetic anhydride and 0.1 part of pyridine according to parts by weight; adding tea polyphenol, acetic anhydride and 0.05 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 20 ℃, the reaction time is 1h, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing and drying to obtain a modified tea polyphenol intermediate 1; adding all the prepared modified tea polyphenol intermediate 1, 30 parts of ethyl acetate and 0.05 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 20 ℃, the reaction time is 2 hours, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing, drying and drying to obtain the modified tea polyphenol.
S2, weighing 30 parts of chitin, 3 parts of ammonium persulfate, 10 parts of sodium hydroxide, 200 parts of water and 10 parts of tetrasodium iminodisuccinate according to parts by weight; adding tetrasodium iminodisuccinate and sodium hydroxide into water under the magnetic stirring state, dissolving, then adding chitin and ammonium persulfate into the solution, stirring uniformly, adding into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 60 ℃, the reaction time is 72 hours, performing suction filtration and drying to obtain a modified chitin intermediate 1, and adding all the prepared modified chitin intermediate 1, 30 parts of isopropanol and 3 parts of bromoacetic acid into the reaction kettle, wherein the internal environment temperature of the reaction kettle is 20 ℃, and the reaction time is 1 hour to obtain the modified chitin.
S3: weighing 80 parts of solvent, 0.2 part of saffron essential oil, 1 part of modified tea polyphenol, 1 part of modified chitin and 1 part of propolis according to the parts by weight, and putting the solvent, the saffron crocus essential oil, the modified tea polyphenol, the modified chitin and the propolis into an emulsifying machine, wherein the rotating speed of the emulsifying machine is 1000r/min, and the processing time is 1h to obtain a solution 1; and then putting the solution 1 and 0.1 part of thickening agent into a jacket dissolving pot, treating at 90 ℃ for 30min, and cooling to obtain the composition with the acne removing effect.
Experimental example 3:
s1, weighing 4 parts of tea polyphenol, 200 parts of acetic anhydride and 0.5 part of pyridine according to parts by weight; adding tea polyphenol, acetic anhydride and 0.3 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 80 ℃, the reaction time is 4 hours, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing and drying to obtain a modified tea polyphenol intermediate 1; and adding all the prepared modified tea polyphenol intermediate 1, 200 parts of ethyl acetate and 0.2 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 80 ℃, the reaction time is 8 hours, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing, drying and drying to obtain the modified tea polyphenol.
S2, weighing 50 parts of chitin, 5 parts of ammonium persulfate, 30 parts of sodium hydroxide, 1000 parts of water and 30 parts of tetrasodium iminodisuccinate according to parts by weight; adding tetrasodium iminodisuccinate and sodium hydroxide into water under the magnetic stirring state, dissolving, then adding chitin and ammonium persulfate into the solution, stirring uniformly, adding into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 50 ℃, the reaction time is 48 hours, performing suction filtration and drying to obtain a modified chitin intermediate 1, adding all the prepared modified chitin intermediate 1, 100 parts of isopropanol and 8 parts of bromoacetic acid into the reaction kettle, wherein the internal environment temperature of the reaction kettle is 80 ℃, and the reaction time is 6 hours to obtain the modified chitin.
S3: weighing 90 parts of solvent, 0.3 part of saffron essential oil, 3 parts of modified tea polyphenol, 2 parts of modified chitin and 5 parts of propolis according to the parts by weight, and putting the solvent, the saffron crocus essential oil, the modified tea polyphenol, the modified chitin and the propolis into an emulsifying machine, wherein the rotating speed of the emulsifying machine is 1000r/min, and the processing time is 1h to obtain a solution 1; and then putting the solution 1 and 0.15 part of thickening agent into a jacket dissolving pot, treating at 90 ℃ for 30min, and cooling to obtain the composition with the acne removing effect.
Comparative example 1:
s1, weighing 40 parts of chitin, 4 parts of ammonium persulfate, 20 parts of sodium hydroxide, 700 parts of water and 20 parts of tetrasodium iminodisuccinate according to parts by weight; adding tetrasodium iminodisuccinate and sodium hydroxide into water under the magnetic stirring state, dissolving, then adding chitin and ammonium persulfate into the solution, stirring uniformly, adding into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 40 ℃, the reaction time is 36 hours, performing suction filtration and drying to obtain a modified chitin intermediate 1, adding all prepared chitin intermediate 1, 80 parts of isopropanol and 6 parts of bromoacetic acid into the reaction kettle, wherein the internal environment temperature of the reaction kettle is 60 ℃, and the reaction time is 4 hours to obtain the modified chitin.
S2: weighing 85 parts of solvent, 0.25 part of saffron crocus essential oil, 2 parts of tea polyphenol, 1.5 parts of modified chitin and 2 parts of propolis according to the parts by weight, and putting the solvent, the saffron crocus essential oil, the tea polyphenol, the modified chitin and the propolis into an emulsifying machine, wherein the rotating speed of the emulsifying machine is 1000r/min, and the processing time is 1h to obtain a solution 1; and then putting the solution 1 and 0.12 part of thickening agent into a jacket dissolving pot, treating at 90 ℃ for 30min, and cooling to obtain the composition with the acne removing effect.
Comparative example 2:
s1, weighing 3 parts of tea polyphenol, 100 parts of acetic anhydride and 0.3 part of pyridine according to parts by weight; adding tea polyphenol, acetic anhydride and 0.1 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 50 ℃, the reaction time is 3 hours, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing and drying to obtain a modified tea polyphenol intermediate 1; and adding all prepared modified tea polyphenol intermediates, 100 parts of ethyl acetate and 0.2 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 60 ℃, the reaction time is 5 hours, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing, drying and drying to obtain the modified tea polyphenol.
S2: weighing 85 parts of solvent, 0.25 part of saffron essential oil, 2 parts of modified tea polyphenol, 1.5 parts of chitin and 2 parts of propolis according to the parts by weight, and putting the solvent, the saffron crocus essential oil, the modified tea polyphenol, the modified chitin and the propolis into an emulsifying machine, wherein the rotating speed of the emulsifying machine is 1000r/min, and the processing time is 1h to obtain a solution 1; and then putting the solution 1 and 0.12 part of thickening agent into a jacket dissolving pot, treating at 90 ℃ for 30min, and cooling to obtain the composition with the acne removing effect.
Comparative example 3:
s1, weighing 3 parts of tea polyphenol, 100 parts of acetic anhydride and 0.3 part of pyridine according to parts by weight; adding tea polyphenol, acetic anhydride and 0.1 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 50 ℃, the reaction time is 3 hours, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing and drying to obtain a modified tea polyphenol intermediate 1; and adding all prepared modified tea polyphenol intermediates, 100 parts of ethyl acetate and 0.2 part of pyridine into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 60 ℃, the reaction time is 5 hours, and after the reaction is finished, performing low-temperature rotary evaporation on the solution, freezing, drying and drying to obtain the modified tea polyphenol.
S2, weighing 40 parts of chitin, 4 parts of ammonium persulfate, 20 parts of sodium hydroxide, 700 parts of water and 20 parts of tetrasodium iminodisuccinate according to parts by weight; adding tetrasodium iminodisuccinate and sodium hydroxide into water under the magnetic stirring state, dissolving, then adding chitin and ammonium persulfate into the solution, stirring uniformly, adding into a reaction kettle, wherein the internal environment temperature of the reaction kettle is 40 ℃, the reaction time is 36 hours, performing suction filtration and drying to obtain a modified chitin intermediate 1, adding all prepared chitin intermediate 1, 80 parts of isopropanol and 6 parts of bromoacetic acid into the reaction kettle, wherein the internal environment temperature of the reaction kettle is 60 ℃, and the reaction time is 4 hours to obtain the modified chitin.
S3: weighing 85 parts of solvent, 2 parts of modified tea polyphenol, 1.5 parts of modified chitin and 2 parts of propolis according to parts by weight, and putting the solvent, the modified tea polyphenol, the modified chitin and the propolis into an emulsifying machine, wherein the rotating speed of the emulsifying machine is 1000r/min, and the processing time is 1h to obtain a solution 1; and then putting the solution 1 and 0.12 part of thickening agent into a jacket dissolving pot, treating at 90 ℃ for 30min, and cooling to obtain the composition with the acne removing effect.
Examples 1 to 3 and comparative examples 1 to 3 were examined according to the following examination methods, and the results are shown in tables 1 to 5.
Skin test:
whelk patients:
in testing the performance of the combination groups prepared in each example or comparative example, 10 volunteers having skin acne of 15 to 18 years old were selected and tested, and the volunteers applied the compositions prepared in examples 1 to 3 and comparative examples 1 to 3 to the face after cleaning the face in the morning and evening every day for a test period of 4 months, and the skin condition was observed at 1 week, 6 weeks, 12 weeks and 16 weeks after application of the present invention, and followed for 1 year after completion of the treatment.
Patient with intractable acne
In testing the performance of the combination groups prepared in each example or comparative example, 10 volunteers of patients with intractable acne of 25 to 35 years old were selected and tested, and the volunteers applied the compositions prepared in examples 1 to 3 and comparative examples 1 to 3 to the face after cleaning the face in the morning and evening every day for a test period of 4 months, and the skin condition was observed at 1 week, 6 weeks, 12 weeks and 16 weeks after the application of the present invention, and followed for 1 year.
TABLE 1 test results (week 1)
TABLE 2 test results (week 6)
TABLE 3 test results (week 12)
TABLE 4 test results (week 16)
TABLE 5 test results (after 1 year of follow-up)
From the results of examples 1 to 3, it can be seen that the skin of the volunteers using the present invention recovered very rapidly at weeks 1, 6 and 12 and all healed at week 16 without leaving the acne mark, regardless of whether the patients were whelk or intractable acne, and all the volunteers did not recur after tracking for 1 year, indicating that the present invention is very excellent in the acne removing effect.
It can be seen from the results of examples 1 to 3 and comparative example 1 that the skin of the volunteers recovered very slowly without modifying tea polyphenol during the preparation of the invention and the skin of the volunteers, although cured for a long time, were easily left with pox marks.
It can be seen from the results of examples 1-3 and comparative example 2 that when chitin was not modified in the preparation process of the invention, the skin recovery of volunteers was very slow, and patients were easy to relapse after healing and aggravated after drug withdrawal.
It can be seen from the results of examples 1-3 and comparative example 3 that the skin recovery of the volunteers was very slow but there was no substantial recurrence after healing when the saffron essential oil was not used for modification during the preparation of the invention.
In the invention, when the modified tea polyphenol, the modified chitin and the saffron essential oil are used simultaneously, the acne treatment liquid has good effect on acne or intractable acne, and the inventor finds that the modified tea polyphenol has good effect on removing acne marks in the research process, and the modified chitin has good effect on preventing relapse.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (10)
1. The composition with the acne removing effect is characterized by comprising the following components:
80-90 parts of a solvent;
0.1-0.15 part of thickening agent;
0.2-0.3 part of saffron crocus essential oil;
1-3 parts of modified tea polyphenol;
1-2 parts of modified chitin;
1-5 parts of propolis.
2. The composition with the acne removing effect according to claim 1, wherein the modified tea polyphenol comprises the following components:
1-4 parts of tea polyphenol;
30-200 parts of acetic anhydride;
30-200 parts of ethyl acetate;
0.1-0.5 part of pyridine.
3. The composition with the acne removing effect according to claim 2, wherein the modified tea polyphenol is prepared by the following steps:
s1, weighing the tea polyphenol, the acetic anhydride and the pyridine according to the weight parts;
s2, adding tea polyphenol, acetic anhydride and pyridine into a reaction kettle, setting reaction conditions, and carrying out low-temperature rotary evaporation and freeze drying on the solution to obtain a modified tea polyphenol intermediate 1;
s3: and (4) adding all the modified tea polyphenol intermediate 1 prepared in the step (S2), ethyl acetate and pyridine in a certain weight ratio into a reaction kettle, setting reaction conditions, performing low-temperature rotary evaporation on the solution, freezing, drying and drying to obtain the modified tea polyphenol.
4. The composition with the acne removing effect according to claim 3,
the reaction condition of the step S2 is that the temperature is 20-80 ℃ and the time is 1-4 h;
the reaction conditions of the step S3 are that the temperature is 20-80 ℃ and the time is 2-8 h.
5. The composition with the acne removing effect according to claim 1, wherein the modified chitin comprises the following components:
30-50 parts of chitin;
10-30 parts of tetrasodium iminodisuccinate;
3-5 parts of ammonium persulfate;
200 portions of water and 1000 portions of water;
10-30 parts of sodium hydroxide;
30-100 parts of isopropanol;
3-8 parts of bromoacetic acid.
6. The composition with the acne removing effect according to claim 5, wherein the modified chitin is prepared by the following steps:
s1, weighing chitin, sodium hydroxide and tetrasodium iminodisuccinate according to the weight parts;
s2, adding tetrasodium iminodisuccinate and sodium hydroxide into water under the magnetic stirring state, dissolving, then putting chitin and ammonium persulfate into the solution, stirring uniformly and putting into a reaction kettle, setting reaction conditions, and performing suction filtration and drying to obtain a modified chitin intermediate 1;
and S3, adding all the modified chitin intermediate 1 in the step S2, isopropanol and bromoacetic acid in a certain mass ratio into a reaction kettle, and setting reaction conditions to obtain the modified chitin.
7. The composition with the acne removing effect according to claim 6,
the reaction condition of the step S2 is that the temperature is 15-50 ℃ and the time is 3-72 h;
the reaction condition of the step S3 is that the temperature is 20-80 ℃ and the time is 1-6 h.
8. A composition with acne removing effect as claimed in any one of claims 1-7, wherein the composition is used in the field of medicine.
9. A composition with acne removing effect according to any one of claims 1 to 7, wherein the composition is used in the field of acne removal.
10. The composition with the acne removing effect is characterized in that the preparation process of the composition comprises the following steps:
s1, weighing tea polyphenol, acetic anhydride and pyridine according to the parts by weight; adding tea polyphenol, acetic anhydride and pyridine into a reaction kettle, setting reaction conditions, wherein the internal environment temperature of the reaction kettle is 20-80 ℃, and after the reaction is finished for 1-4 hours, drying the solution to obtain a modified tea polyphenol intermediate 1; adding all prepared modified tea polyphenol intermediates, ethyl acetate and residual pyridine in a certain weight ratio into a reaction kettle, setting reaction conditions, controlling the internal environment temperature of the reaction kettle to be 20-80 ℃, controlling the reaction time to be 2-8h, and drying the solution after the reaction is finished to obtain modified tea polyphenol;
s2, weighing chitin, ammonium persulfate, sodium hydroxide, water and tetrasodium iminodisuccinate according to the weight parts; adding tetrasodium iminodisuccinate and sodium hydroxide into water under the magnetic stirring state, dissolving, then adding chitin and ammonium persulfate into the solution, stirring uniformly, adding into a reaction kettle, setting the reaction conditions, wherein the internal environment temperature of the reaction kettle is 40-60 ℃, the reaction time is 36-72 hours, performing suction filtration and drying to obtain a modified chitin intermediate 1, adding all the prepared chitin intermediate 1, isopropanol and bromoacetic acid in a certain mass ratio into the reaction kettle, setting the reaction conditions, wherein the internal environment temperature of the reaction kettle is 20-80 ℃, and the reaction time is 1-6 hours to obtain the modified chitin;
s3: weighing a solvent, saffron crocus essential oil, modified tea polyphenol, modified chitin and propolis according to parts by weight, putting the solvent, the saffron crocus essential oil, the modified tea polyphenol, the modified chitin and the propolis into an emulsifying machine, setting parameters of an emulsifying agent, wherein the rotating speed of the emulsifying machine is 1000r/min, and the processing time is 1h to obtain a solution 1; and then putting the solution 1 and the thickening agent into a jacket dissolving pot, setting reaction conditions, treating at 90 ℃ for 30min, and cooling to obtain the composition with the acne removing effect.
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| CN103601819A (en) * | 2013-12-04 | 2014-02-26 | 武汉大学 | Method for homogeneous preparation of carboxyl chitin with low deacetylation degree and application of carboxyl chitin |
| CN104164754A (en) * | 2014-07-30 | 2014-11-26 | 上海圣得生物工程技术有限公司 | Chitin non-woven fabric and application thereof |
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| CN108815092A (en) * | 2018-07-02 | 2018-11-16 | 芜湖扬展新材料科技服务有限公司 | A kind of preparation method of the anti-acne maintenance Essence containing tea polyphenols |
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| CN103601819A (en) * | 2013-12-04 | 2014-02-26 | 武汉大学 | Method for homogeneous preparation of carboxyl chitin with low deacetylation degree and application of carboxyl chitin |
| CN104164754A (en) * | 2014-07-30 | 2014-11-26 | 上海圣得生物工程技术有限公司 | Chitin non-woven fabric and application thereof |
| CN108294995A (en) * | 2018-04-04 | 2018-07-20 | 刘凡领 | A kind of preparation method of acne eliminating cream |
| CN108815092A (en) * | 2018-07-02 | 2018-11-16 | 芜湖扬展新材料科技服务有限公司 | A kind of preparation method of the anti-acne maintenance Essence containing tea polyphenols |
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