CN114832238A - System and method for determining transcranial magnetic stimulation target - Google Patents

Abstract

The invention discloses a transcranial magnetic stimulation target point determining system and a method, wherein the system comprises: the device comprises a signal acquisition module, a signal processing module and a target point determination module; the signal acquisition module is used for acquiring electrocardiosignals of a target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation targets and sending the electrocardiosignals to the signal processing module; the signal processing module is connected with the signal acquisition module and used for receiving the electrocardiosignals, processing the electrocardiosignals to obtain R peak detection signals and sending the R peak detection signals to the target point determination module; and the target point determining module is connected with the signal processing module and is used for acquiring the R peak detection signal and determining a target point from at least two stimulation target points for performing transcranial magnetic stimulation on the target object according to the R peak detection signal. Through the technical scheme of the embodiment of the invention, the technical effect of accurately determining the position of the target point according to the electrocardiosignal is realized.

Description

Transcranial magnetic stimulation target determination system and method

technical field

The invention relates to the technical field of transcranial magnetic stimulation, in particular to a system and method for determining a target point of transcranial magnetic stimulation.

Background technique

Repetitive transcranial magnetic stimulation (rTMS) can relieve symptoms in patients with treatment-resistant depression. At present, clinical treatment usually places a transcranial magnetic stimulation coil in the dorsolateral prefrontal cortex (DLPFC), and a magnetic field is generated by the rapidly changing current in the coil, and the current is induced in the DLPFC cortex, so that the cortex of the corresponding area is induced. Neurons generate evoked potentials due to induced firing, which are conducted along axons to neurons. Through non-invasive means to adjust the local cortex and brain network of the cerebral cortex, reduce the symptoms of depression patients.

The therapeutic effect of repetitive transcranial magnetic stimulation has a strong correlation with the stimulation target. Currently, transcranial magnetic stimulation localization can be performed by the "5 cm" method. However, because this approach does not take into account differences in head size or anatomy, it can lead to stimulation of unrelated cortical layers, which can lead to poor outcomes when treated with rTMS.

SUMMARY OF THE INVENTION

The invention provides a system and method for determining the target point of transcranial magnetic stimulation, so as to solve the problem of inaccurate determination of the target point position during transcranial magnetic stimulation, and realize the technical effect of accurately determining the target point position according to the electrocardiographic signal.

According to an aspect of the present invention, a system for determining a target point of transcranial magnetic stimulation is provided. The system includes: a signal acquisition module, a signal processing module, and a target point determination module; wherein,

The signal acquisition module is configured to acquire the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation targets, and send the ECG signal to the signal processing module;

The signal processing module, connected with the signal acquisition module, is used for receiving the ECG signal, processing the ECG signal, obtaining an R peak detection signal, and sending the R peak detection signal to the target Click to confirm the module;

The target point determination module is connected with the signal processing module, and is used for acquiring the R peak detection signal, and according to the R peak detection signal, from at least two objects that perform transcranial magnetic stimulation on the target object. Determine the target target in the stimulation target.

According to another aspect of the present invention, there is provided a method for determining a target point of transcranial magnetic stimulation, the method comprising:

Based on the signal acquisition module, acquire the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation targets, and send the ECG signal to the signal processing module;

Based on the signal processing module, receive the ECG signal, process the ECG signal to obtain an R peak detection signal, and send the R peak detection signal to the target point determination module;

Based on the target point determination module, the R peak detection signal is acquired, and according to the R peak detection signal, a target target point is determined from at least two stimulation target points for transcranial magnetic stimulation for the target object.

According to the technical solution of the embodiment of the present invention, the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points is acquired through the signal acquisition module, and the ECG signal is received based on the signal processing module, and the ECG signal is processed on the ECG signal. Process, obtain the R peak detection signal, obtain the R peak detection signal based on the target point determination module, and determine the target target point from at least two stimulation targets for transcranial magnetic stimulation for the target object according to the R peak detection signal, which solves the problem of The problem of inaccurate target location during transcranial magnetic stimulation achieves the technical effect of accurately determining the target location according to the ECG signal.

It should be understood that the content described in this section is not intended to identify key or critical features of the embodiments of the invention, nor is it intended to limit the scope of the invention. Other features of the present invention will become readily understood from the following description.

Description of drawings

In order to illustrate the technical solutions in the embodiments of the present invention more clearly, the following briefly introduces the accompanying drawings used in the description of the embodiments. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can also be obtained from these drawings without creative effort.

FIG. 1 is a schematic structural diagram of a system for determining a target point of transcranial magnetic stimulation provided by Embodiment 1 of the present invention;

FIG. 2 is a schematic structural diagram of a system for determining a target point of transcranial magnetic stimulation provided by Embodiment 2 of the present invention;

3 is a schematic structural diagram of another transcranial magnetic stimulation target determination system provided in Embodiment 2 of the present invention;

4 is a schematic waveform diagram of a method for determining a target point according to Embodiment 2 of the present invention;

FIG. 5 is a schematic flowchart of a method for determining a target point of transcranial magnetic stimulation provided by Embodiment 3 of the present invention.

Detailed ways

In order to make those skilled in the art better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only Embodiments are part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

It should be noted that the terms "preset", "target" and the like in the description and claims of the present invention and the above drawings are used to distinguish similar objects, and are not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used may be interchanged under appropriate circumstances such that the embodiments of the invention described herein can be practiced in sequences other than those illustrated or described herein. Furthermore, the terms "comprising" and "for", and any variations thereof, are intended to cover non-exclusive inclusion, eg, a process, method, system, product or device comprising a series of steps or units not necessarily limited to those expressly listed but may include other steps or units not expressly listed or inherent to these processes, methods, products or devices.

It can be understood that the data involved in this technical solution (including but not limited to the data itself, the acquisition or use of the data) shall comply with the requirements of the corresponding laws and regulations and relevant regulations.

Example 1

FIG. 1 is a schematic structural diagram of a system for determining a transcranial magnetic stimulation target point according to Embodiment 1 of the present invention. This embodiment can be applied to the situation of determining the target point of transcranial magnetic stimulation, and the system can execute the target point of transcranial magnetic stimulation. The point determination method, the transcranial magnetic stimulation target determination system can be implemented in the form of hardware and/or software, and the transcranial magnetic stimulation target determination system can be configured in the transcranial magnetic stimulation system. As shown in FIG. 1 , the system includes: a signal acquisition module 1 , a signal processing module 2 and a target point determination module 3 .

Among them, the signal acquisition module 1 is used to acquire the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points, and send the ECG signal to the signal processing module 2; the signal processing module 2, It is connected with the signal acquisition module 1, used to receive the ECG signal, process the ECG signal, obtain the R peak detection signal, and send the R peak detection signal to the target point determination module 3; the target point determination module 3, and the signal The processing module 2 is connected to obtain an R peak detection signal, and according to the R peak detection signal, determine a target point from at least two stimulation targets for transcranial magnetic stimulation for the target object.

The signal acquisition module 1 is used for acquiring the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation targets, and sending the ECG signal to the signal processing module 2 .

Among them, the stimulation target can be an alternative target selected in the subsequent transcranial magnetic stimulation, for example: stimulating three different positions of the left dorsolateral prefrontal cortex (DLPFC) of the cortex (International 10-20 Brain F3, FC3, C3) in the electrogram system, etc., the specific stimulation targets can be selected according to the stimulation needs. The target subject may be a subject undergoing transcranial magnetic stimulation. The electrocardiographic signal may be a bioelectrical signal obtained by measuring the target object via an electrocardiographic device, and is used to record the electrical activity generated by the heart in each cardiac cycle.

Specifically, when transcranial magnetic stimulation is performed, at least two stimulation targets can be selected for the target object in advance, and transcranial magnetic stimulation can be performed at the position of each stimulation target by the transcranial magnetic stimulator. Furthermore, the ECG signal during the transcranial magnetic stimulation can be collected by the ECG device, and the collected ECG signal can be sent to the signal processing module 2 to process and analyze the ECG signal.

The signal processing module 2 is used to receive the ECG signal, process the ECG signal, obtain the R peak detection signal, and send the R peak detection signal to the target point determination module 3 .

The R peak detection signal may be a signal that highlights the R wave in the ECG signal.

Specifically, the signal processing module 2 can obtain the ECG signal from the signal acquisition module 1, and perform processing such as removing 50Hz power frequency interference, baseline drift, and high and low frequency noise on the ECG signal, so as to analyze the R wave in the ECG signal. Highlighting facilitates subsequent detection of each R-peak so that selection from each stimulus target can be based on the R-peak.

The target point determination module 3 is used for acquiring the R peak detection signal, and according to the R peak detection signal, determining the target target point from at least two stimulation target points for performing transcranial magnetic stimulation on the target object.

Wherein, the target can be a target suitable for subsequent transcranial magnetic stimulation among the at least two stimulation targets.

Specifically, the target point determination module 3 can obtain the R peak detection signal from the signal processing module 2, and analyze it according to the R peak detection signal, so as to determine the stimulation target point that can effectively reduce the heart rate of the target object as the target target point.

According to the technical solution of the embodiment of the present invention, the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points is acquired through the signal acquisition module, and the ECG signal is received based on the signal processing module, and the ECG signal is processed on the ECG signal. Process, obtain the R peak detection signal, obtain the R peak detection signal based on the target point determination module, and determine the target target point from at least two stimulation targets for transcranial magnetic stimulation for the target object according to the R peak detection signal, which solves the problem of The problem of inaccurate target location during transcranial magnetic stimulation achieves the technical effect of accurately determining the target location according to the ECG signal.

Embodiment 2

2 is a schematic structural diagram of a transcranial magnetic stimulation target determination system provided in Embodiment 2 of the present invention. On the basis of the above embodiment, the The specific structure will be described.

As shown in FIG. 2 , the signal processing module 1 is specifically used for: receiving an ECG signal, filtering the ECG signal based on a pre-designed notch filter, and obtaining an R peak detection signal corresponding to the ECG signal.

The notch filter may be designed based on FIR (Finite Impulse Response, finite unit impulse response), that is, a low-pass filter and a high-pass filter are connected in series.

Specifically, a notch filter can be designed for the ECG signal to remove 50Hz power frequency interference, baseline drift and high and low frequency noise. The ECG signal is filtered through a notch filter, and the filtered ECG signal is determined as the R peak detection signal.

Optionally, the system further includes: a waveform correction module 4 .

The waveform correction module 4 is connected to the signal processing module 2, and is used for acquiring the R peak detection signal from the signal processing module 2, correcting the waveform spacing of the R peak detection signal, and updating the R peak detection signal based on the corrected signal.

Specifically, the ECG signal can be differentiated by the waveform correction module 4, so that the difference between the R wave peaks forms a positive and negative value pair. In the difference operation result, find the positive and negative values of the largest modulus as the R wave threshold, that is, the R wave positive threshold and the R wave negative threshold. Multiply the R wave threshold by a preset coefficient (for example, a coefficient 0.5 determined according to a statistical test) to obtain a new R wave threshold. The ECG signal is processed according to the R wave threshold, and the part greater than the positive R wave threshold is determined as a positive peak, and the part less than the negative R wave threshold is determined as a negative peak. Take the midpoint of the adjacent positive and negative peaks as the current R wave position. Furthermore, according to the physiological characteristics of the QRS complex, the interval between the detected waveforms (ie, the RR interval) is corrected to remove the waveforms that are much smaller than the average value of the RR interval; Detection, in order to achieve the purpose of waveform correction of the R peak detection signal, and update the R peak detection signal.

Optionally, the signal acquisition module 1 includes: a stimulation intensity determination unit 11 , a transcranial magnetic stimulator 12 and an electrocardiograph 13 .

Wherein, the stimulation intensity determination unit 11 is used to obtain the resting motion threshold of the target object, and determine the stimulation intensity of the transcranial magnetic stimulation according to the resting motion threshold; the transcranial magnetic stimulator 12 is connected to the stimulation intensity determination unit 11, Used to obtain the stimulation intensity, and based on the stimulation intensity, preset stimulation duration, preset stimulation interval and at least two stimulation targets, perform transcranial magnetic stimulation on the target object; the electrocardiograph 13 is used to measure and collect the target object during Electrocardiographic signals during transcranial magnetic stimulation.

The stimulation intensity determination unit 11 is configured to acquire the resting motion threshold of the target object, and determine the stimulation intensity of the transcranial magnetic stimulation according to the resting motion threshold.

The resting motor threshold can be the minimum stimulation intensity required for transcranial magnetic stimulation to stimulate the motor cortex, and at least 5 out of 10 stimulations evoke a target muscle (usually abductor pollicis brevis) motor evoked potential with an amplitude exceeding 50 μv. The stimulation intensity may be the intensity that is subsequently used for transcranial magnetic stimulation.

Specifically, the resting motion threshold corresponding to the target object may be determined by measuring the resting motion threshold. Further, the resting motion threshold is multiplied by a preset multiple to obtain the stimulation intensity. Exemplarily, the stimulus intensity may be 110% of the resting motion threshold.

The transcranial magnetic stimulator 12 is used for acquiring stimulation intensity, and performing transcranial magnetic stimulation on the target object based on the stimulation intensity, preset stimulation duration, preset stimulation interval and at least two stimulation targets.

The preset stimulation duration may be the duration of continuous stimulation during transcranial magnetic stimulation. The preset stimulation interval can be the time interval between two adjacent transcranial magnetic stimulations.

Specifically, the transcranial magnetic stimulator 12 can acquire the stimulation intensity determined by the stimulation intensity determination unit 11, and at each stimulation target point of the target object, perform transcranial magnetic stimulation with a preset stimulation duration with the stimulation intensity. The interval between sub-transcranial magnetic stimulation was preset stimulation interval.

The electrocardiograph 13 is used to measure and collect the electrocardiogram signal of the target object during the transcranial magnetic stimulation.

Specifically, the electrocardiograph 13 can continuously measure the electrocardiographic signal of the target object, that is, the electrocardiographic signal of the target object during transcranial magnetic stimulation.

Optionally, the target point determination module 3 includes: a stimulation time period determination submodule 31 , a RR interval difference determination submodule 32 , and a target target point determination submodule 33 .

Among them, the stimulation time period determination sub-module 31 is used to obtain at least two stimulation targets for transcranial magnetic stimulation for the target object and the stimulation period corresponding to each stimulation target point; the RR interval difference determination sub-module 32, connected with the stimulation time period determination sub-module 31, for obtaining the stimulation time period corresponding to each stimulation target point, for each stimulation time period, from the R peak detection signal to determine the corresponding stimulation time period; RR interval difference; send each stimulation target and the RR interval difference corresponding to each stimulation target to the target target determination submodule 33; the target target determination submodule 33, and the RR interval difference The determination sub-module 32 is connected to obtain each stimulation target point and the RR interval difference value corresponding to each stimulation target point, determine the target difference value according to each RR interval difference value, and calculate the corresponding target difference value. Stimulate the target as the target target.

The stimulation time period determination sub-module 31 is used for acquiring at least two stimulation targets for transcranial magnetic stimulation for the target object and a stimulation period corresponding to each stimulation target point.

The stimulation time period can be the time period during which transcranial magnetic stimulation is performed for any stimulation target. For example, for stimulation target A, if transcranial magnetic stimulation is performed at 0-5s, then 0-5s can be used as stimulation The stimulation time period corresponding to target A; if transcranial magnetic stimulation is performed at 0-5s and 30-35s, both 0-5s and 30-35s can be used as the stimulation time period corresponding to target A.

Specifically, based on the stimulation time period sub-module 31 can obtain the stimulation time period for performing transcranial magnetic stimulation, that is, the time period during which stimulation is continuously performed at each stimulation target.

The RR interval difference determination submodule 32 is used to obtain the stimulation time period corresponding to each stimulation target point, and for each stimulation time period, determine the RR interval corresponding to the stimulation time period from the R peak detection signal Difference value; send each stimulation target point and the RR interval difference value corresponding to each stimulation target point to the target target point determination sub-module 33 .

Wherein, the RR interval difference can be the difference between the maximum value and the minimum value of the RR interval in the stimulation time period. The RR interval can be the interval time between each heart beat, that is, the time interval between two heart beats can be obtained according to the distance between two R waves.

Specifically, the stimulation time period corresponding to each stimulation target point is determined, and each stimulation time period is processed separately. Therefore, a stimulation time period is used as an example for description. Determine each RR interval in the stimulation time period, and obtain the difference between the maximum value and the minimum value from the maximum value and the minimum value in the determined RR interval as the RR interval difference. Furthermore, after the RR interval difference corresponding to each stimulation target point is determined, the corresponding stimulation target point and the RR interval difference are sent to the target target point determination sub-module 33 .

The target target point determination sub-module 33 is connected with the RR interval difference determination sub-module 32, and is used to obtain each stimulation target point and the RR interval difference value corresponding to each stimulation target point. value, determine the target difference, and use the stimulus target corresponding to the target difference as the target.

Wherein, the target difference may be the maximum value among the RR interval differences.

Specifically, the maximum value is determined from the acquired RR interval differences as the target difference, and further, the stimulation target corresponding to the target difference is used as the target for subsequent transcranial magnetic stimulation.

It should be noted that patients with depression have impaired autonomic regulation and are clinically manifested by higher heart rate and lower heart rate variability. The dysregulated DLPFC and SGC (subgenual cingulate cortex, subgenual cingulate cortex) in depression are connected to cardiac function through the vagus nerve (VN). Using the DLPFC-VN neural network, rTMS stimulation of the DLPFC can reduce the patient's heart rate. The stimulation site with the most significant reduction in heart rate was the most functionally connected to the DLPFC-VN neural network, thereby identifying the optimal stimulation target for rTMS in the treatment of depression.

Optionally, the RR interval difference determination sub-module 32 includes: an RR interval determination unit 321 , an RR interval difference determination unit 322 and a sending unit 323 .

Wherein, the RR interval determination unit 321 is configured to acquire the R peak detection signal, and determine at least two maximum peaks corresponding to the R peak detection signal, and determine at least one RR interval and each RR according to the at least two maximum peaks The time position corresponding to the interval; the RR interval difference determination unit 322 is connected with the RR interval determination unit 321, and is used to obtain the stimulation time period corresponding to each stimulation target point, and for each stimulation time period, Determine at least two time positions corresponding to the stimulation time period from each time position, and determine the RR interval corresponding to the stimulation time period according to the maximum RR interval and the minimum RR interval corresponding to the at least two time positions difference; the sending unit 323 is connected to the RR interval difference determination unit 322, and is used to obtain the RR interval difference corresponding to the stimulation time period, and send each RR interval difference to the target target point determiner Module 33.

The RR interval determination unit 321 is configured to acquire the R peak detection signal, determine at least two maximum peaks corresponding to the R peak detection signal, and determine at least one RR interval and each RR interval according to the at least two maximum peaks corresponding time position.

The maximum peak may be the maximum value of each R wave in the R peak detection signal. The temporal position may be the moment corresponding to the largest peak.

Specifically, the RR interval determination unit 321 determines each maximum peak in the R peak detection signal according to the R peak detection signal, and determines the time position corresponding to each maximum peak.

The RR interval difference determination unit 322 is configured to obtain a stimulation time period corresponding to each stimulation target point, and for each stimulation time period, determine at least two time positions corresponding to the stimulation time period from each time position , and the RR interval difference corresponding to the stimulation time period is determined according to the maximum RR interval and the minimum RR interval corresponding to at least two time positions.

Wherein, the maximum RR interval may be the maximum value among the time difference values determined via two adjacent time positions. The minimum RR interval may be the minimum value of the time difference values determined via two adjacent time positions.

Specifically, for the stimulation time period corresponding to each stimulation target, determine each time position in the stimulation time period, determine the RR interval according to any two adjacent time positions, and determine the maximum value from each RR interval is the maximum RR interval, and the minimum value is determined from each RR interval as the minimum RR interval. Furthermore, the difference between the maximum RR interval and the minimum RR interval is determined as the RR interval difference corresponding to the stimulation time period.

The sending unit 323 is configured to acquire the RR interval difference values corresponding to the stimulation time period, and send each RR interval difference value to the target target point determination sub-module 33 .

Optionally, the target target point determination sub-module 33 includes: a target difference value determination unit 331 and a target target point determination unit 332 .

Among them, the target difference determination unit 331 is used to obtain the RR interval difference value corresponding to each stimulation target point, and determine the minimum value of each RR interval difference value as the target difference value; the target target point determination unit 332, It is connected with the target difference value determining unit 331, and is used to obtain each stimulation target point, obtain the target difference value, and determine the stimulation target point corresponding to the target difference value as the target target point.

The target difference determination unit 331 is configured to acquire the RR interval difference corresponding to each stimulation target point, and determine the minimum value of each RR interval difference as the target difference.

Specifically, the target difference determination unit 331 obtains the RR interval difference value corresponding to each stimulation target point for each stimulation target point, and takes the minimum value of the RR interval difference values corresponding to each stimulation target point as the target difference value.

The target target determination unit 332 is configured to acquire each stimulation target point, obtain the target difference value, and determine the stimulation target point corresponding to the target difference value as the target target point.

Specifically, the target target determination unit 332 is configured to acquire and determine the stimulation target corresponding to the target difference as the target target.

Optionally, the system further includes: a signal synchronization module 5 .

Among them, the signal synchronization module 5 is connected with the signal acquisition module 1 and the signal processing module 2 respectively, and is used for acquiring the high-frequency trigger signal when transcranial magnetic stimulation is performed on the target object, the ECG signal collected by the signal acquisition module, and the signal processing. The R-peak detection signal in the module synchronizes the high-frequency trigger signal, ECG signal and R-peak detection signal according to the signal acquisition time.

The high-frequency trigger signal can be a trigger signal used for transcranial magnetic stimulation, and the high-frequency trigger signal can be sent out at a preset stimulation frequency and stimulation intensity, for example, the stimulation frequency is 10 Hz, and the stimulation intensity is 110% static Inhalation motion threshold.

Specifically, the high-frequency trigger signal during transcranial magnetic stimulation for the target object, the ECG signal collected by the signal acquisition module, and the R peak detection signal in the signal processing module are acquired, and the three signals are synchronized according to the signal acquisition time.

Optionally, the system further includes: a display module 6 .

The display module 6 is connected to the signal synchronization module 5, and is used for acquiring and displaying the synchronized high-frequency trigger signal, ECG signal and R peak detection signal.

Specifically, the display module 6 may be a device such as a display screen for displaying various waveforms of multiple channels. The display module 6 can obtain the synchronized high-frequency trigger signal, ECG signal and R peak detection signal from the signal synchronization module 5, and display these signals, so that the test personnel can observe the waveforms of these three signals synchronously, and Make reasonable judgments about transcranial magnetic stimulation.

FIG. 3 is a schematic structural diagram of another transcranial magnetic stimulation target determination system according to Embodiment 2 of the present invention. As shown in Figure 3, it includes: a transcranial magnetic stimulator, an electrocardiograph, a multi-channel model acquisition card, and a synchronous real-time display system (display module).

When the target object of the repetitive transcranial magnetic stimulation is determined for the target object, the electrocardiographic signal of the target object is collected synchronously. Then, output the ECG signal of the target object and the trigger sequence (high-frequency trigger signal) output by the transcranial magnetic stimulator respectively to the multi-channel signal acquisition card, and convert the ECG signal into the RR interval, and only take the trough of the signal and filter it. In addition to the respiration signal (R peak detection signal). Furthermore, a programming language (eg, python/C++ mixed programming) can be used to build a TMS-ECG recording synchronous display system (synchronous real-time display system). Based on the synchronously displayed ECG signal, trigger sequence and R peak detection signal in the synchronous real-time display system, it is possible to quickly identify the degree of ECG signal change (ie R interval difference) corresponding to each stimulation target, and determine the best rTMS treatment Target (target target).

Exemplarily, the heart rate data of the target object under repetitive transcranial magnetic stimulation ( ECG signal). Repeated transcranial magnetic stimulation was performed on the left DLPFC of the target subject according to the 10-20 scalp EEG electrode positioning system. Filter the ECG signal. Since the QRS signal has significant waveform characteristics, a notch filter is designed based on FIR, that is, a low-pass filter and a high-pass filter are connected in series to remove 50Hz power frequency interference, baseline drift and high and low frequencies. noise. At the same time, keep the difference operation result of the waveform during filtering, find the maximum positive and negative value multiplied by the coefficient 0.5 (statistical result) in the difference result as the threshold of R wave detection, and update the maximum and minimum peak values in real time, taking the positive and negative peak values The midpoint of the two positions is used as the current R wave position. According to the physiological characteristics of the waveform, the interval of the detected waveform is corrected, and the waveform far smaller than the average value is removed; for the waveform far larger than the average value of the interval, the threshold value is lowered and then detected. And display the filtering results in real time. The waveform diagram of the target determination method is shown in Figure 4. The heart rate was recorded at 3 different positions (F3, FC3, C3) of the left DLPFC of the stimulated cortex, and each position lasted for 5 seconds. Here, the y-axis represents the interval between two consecutive R-peaks recorded by the ECG (RR interval). It can be seen from Figure 4 that when the F3 target is stimulated, the RR interval is prolonged (that is, the RR interval difference is the largest), and the target's heart rate is significantly reduced, so F3 can be determined as the target's therapeutic target (target target). ).

It should be noted that the peaks (eg, point a in Figure 4) and troughs (eg, point b in Figure 4) of the RR signal can reflect the heart rate regulation caused by breathing. The difference between the peaks and troughs of the RR signal (RR interval difference) can be used to limit the observation range of subsequent analysis, that is, to maximize the space for detecting RR deceleration, thus effectively eliminating the effect of respiration.

According to the technical solution of the embodiment of the present invention, the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points is acquired through the signal acquisition module, and the ECG signal is received based on the signal processing module, and the ECG signal is processed on the ECG signal. Process, obtain the R peak detection signal, obtain the R peak detection signal based on the target point determination module, and determine the target target point from at least two stimulation targets for transcranial magnetic stimulation for the target object according to the R peak detection signal, which solves the problem of The problem of inaccurate target location during transcranial magnetic stimulation achieves the technical effect of accurately determining the target location according to the ECG signal.

Embodiment 3

FIG. 5 is a schematic flowchart of a method for determining a transcranial magnetic stimulation target according to Embodiment 3 of the present invention. This embodiment can be applied to the case of determining a transcranial magnetic stimulation target. Click OK to execute the system.

As shown in Figure 5, the method of this embodiment specifically includes the following steps:

S510. Based on the signal acquisition module, acquire the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points, and send the ECG signal to the signal processing module.

S520. Based on the signal processing module, receive the ECG signal, process the ECG signal, obtain an R peak detection signal, and send the R peak detection signal to the target point determination module.

S530. Based on the target point determination module, obtain an R peak detection signal, and according to the R peak detection signal, determine a target target point from at least two stimulation target points for transcranial magnetic stimulation on the target object.

Optionally, the ECG signal is received based on the signal processing module, and the ECG signal is filtered based on a pre-designed notch filter to obtain an R peak detection signal corresponding to the ECG signal.

Optionally, the system further includes a waveform correction module; based on the waveform correction module, the R-peak detection signal is obtained from the signal processing module, and the waveform spacing of the R-peak detection signal is corrected, based on the corrected value. The signal updates the R peak detection signal.

Optionally, the target point determination module includes: a stimulation time period determination submodule, a RR interval difference determination submodule, and a target target determination submodule; At least two stimulation targets of magnetic stimulation and the stimulation time period corresponding to each stimulation target; determine the sub-module based on the RR interval difference, obtain the stimulation time period corresponding to each stimulation target, for each Stimulation time period, determine the RR interval difference corresponding to the stimulation time period from the R peak detection signal; send each stimulation target point and the RR interval difference corresponding to each stimulation target point to the Target determination sub-module; based on the target determination sub-module, obtain each stimulation target and the RR interval difference corresponding to each stimulation target, determine the target difference according to each RR interval difference, and The stimulation target point corresponding to the target difference value is used as the target target point.

Optionally, the RR interval difference determination sub-module includes: an RR interval determination unit, an RR interval difference determination unit, and a sending unit; and based on the RR interval determination unit, acquires the R peak detection signal, and determines the R peak detection signal, and determines the R peak detection signal. at least two maximum peaks corresponding to the R peak detection signal, determine at least one RR interval and a time position corresponding to each RR interval according to the at least two maximum peaks; determine the unit based on the RR interval difference, Obtain a stimulation time period corresponding to each stimulation target point, and for each stimulation time period, determine at least two time positions corresponding to the stimulation time period from each time position, and determine at least two time positions corresponding to the stimulation time period according to the at least two times The maximum RR interval and the minimum RR interval corresponding to the position are determined, and the RR interval difference corresponding to the stimulation time period is determined; based on the sending unit, the RR interval difference corresponding to the stimulation time period is obtained, and send each RR interval difference to the target target determination sub-module.

Optionally, the target target point determination sub-module includes: a target difference value determination unit and a target target point determination unit; based on the target difference value determination unit, the RR interval difference value corresponding to each stimulation target point is obtained, and each RR is determined. The minimum value in the interval difference value is the target difference value; based on the target target point determination unit, the stimulation target points are obtained, and the target difference value is obtained, and the stimulation target point corresponding to the target difference value is determined as target target.

Optionally, the signal acquisition module includes: a stimulation intensity determination unit, a transcranial magnetic stimulator, and an electrocardiograph; based on the stimulation intensity determination unit, the resting motion threshold of the target object is acquired, and the resting motion threshold is determined according to the resting motion threshold. The stimulation intensity of cranial magnetic stimulation; based on the transcranial magnetic stimulator, the stimulation intensity is obtained, and based on the stimulation intensity, the preset stimulation duration, the preset stimulation interval and the at least two stimulation targets, the target object is subjected to Transcranial Magnetic Stimulation: Based on an electrocardiograph, measure and collect the ECG signal of the target object during transcranial magnetic stimulation.

Optionally, the system further includes: a signal synchronization module; based on the signal synchronization module, acquiring a high-frequency trigger signal when performing transcranial magnetic stimulation on the target object, the ECG signal collected by the signal collection module, and The R peak detection signal in the signal processing module synchronizes the high frequency trigger signal, the ECG signal and the R peak detection signal according to the signal acquisition time.

Optionally, the system further includes: a display module; based on the display module, acquire and display the synchronized high-frequency trigger signal, the ECG signal, and the R-peak detection signal.

According to the technical solution of the embodiment of the present invention, the ECG signal of the target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points is acquired through the signal acquisition module, and the ECG signal is received based on the signal processing module, and the ECG signal is processed on the ECG signal. Process, obtain the R peak detection signal, obtain the R peak detection signal based on the target point determination module, and determine the target target point from at least two stimulation targets for transcranial magnetic stimulation for the target object according to the R peak detection signal, which solves the problem of The problem of inaccurate target location during transcranial magnetic stimulation achieves the technical effect of accurately determining the target location according to the ECG signal.

It should be understood that steps may be reordered, added or deleted using the various forms of flow shown above. For example, the steps described in the present invention can be performed in parallel, sequentially or in different orders, and as long as the desired results of the technical solutions of the present invention can be achieved, no limitation is imposed herein.

The above-mentioned specific embodiments do not constitute a limitation on the protection scope of the present invention. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions may occur depending on design requirements and other factors. Any modifications, equivalent replacements and improvements made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims (10)

1. A transcranial magnetic stimulation target determination system, comprising: the device comprises a signal acquisition module, a signal processing module and a target point determination module; wherein,

the signal acquisition module is used for acquiring electrocardiosignals of a target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points and sending the electrocardiosignals to the signal processing module;

the signal processing module is connected with the signal acquisition module and used for receiving the electrocardiosignals, processing the electrocardiosignals to obtain R peak detection signals and sending the R peak detection signals to the target point determination module;

the target point determining module is connected with the signal processing module and used for acquiring the R peak detection signal and determining a target point from at least two stimulation target points for performing transcranial magnetic stimulation on the target object according to the R peak detection signal.

2. The system of claim 1, wherein the signal processing module is specifically configured to:

and receiving the electrocardiosignals, and filtering the electrocardiosignals based on a pre-designed notch filter to obtain R peak detection signals corresponding to the electrocardiosignals.

3. The system of claim 2, further comprising: a waveform modification module, wherein,

the waveform correction module is connected with the signal processing module and used for acquiring the R peak detection signal from the signal processing module, correcting the waveform interval of the R peak detection signal and updating the R peak detection signal based on the corrected signal.

4. The system of claim 1, wherein the target determination module comprises: a stimulation time period determining submodule, an RR interval difference determining submodule and a target point determining submodule; wherein,

the stimulation time period determination submodule is used for acquiring at least two stimulation target points for performing transcranial magnetic stimulation on the target object and a stimulation time period corresponding to each stimulation target point;

the RR interval difference determining submodule is connected with the stimulation time period determining submodule and is used for acquiring a stimulation time period corresponding to each stimulation target point, and determining an RR interval difference corresponding to the stimulation time period from the R peak detection signal aiming at each stimulation time period; sending each stimulation target point and the RR interval difference value corresponding to each stimulation target point to the target point determining submodule;

the target point determining submodule is connected with the RR interval difference determining submodule and is used for obtaining each stimulation target point and the RR interval difference corresponding to each stimulation target point, determining a target difference according to each RR interval difference, and taking the stimulation target point corresponding to the target difference as the target point.

5. The system of claim 4, wherein the RR interval difference determination submodule comprises: an RR interval determining unit, an RR interval difference determining unit and a sending unit; wherein,

the RR interval determining unit is used for acquiring the R peak detection signal, determining at least two maximum peaks corresponding to the R peak detection signal, and determining at least one RR interval and a time position corresponding to each RR interval according to the at least two maximum peaks;

the RR interval difference determining unit is connected with the RR interval determining unit and is used for acquiring a stimulation time period corresponding to each stimulation target point, determining at least two time positions corresponding to the stimulation time period from each time position aiming at each stimulation time period, and determining RR interval differences corresponding to the stimulation time periods according to the maximum RR intervals and the minimum RR intervals corresponding to the at least two time positions;

the sending unit is connected with the RR interval difference value determining unit and used for obtaining RR interval difference values corresponding to the stimulation time periods and sending the RR interval difference values to the target point determining submodule.

6. The system of claim 4, wherein the target determination submodule comprises: a target difference determining unit and a target point determining unit; wherein,

the target difference determining unit is used for acquiring RR interval differences corresponding to each stimulation target point and determining the minimum value in the RR interval differences as a target difference;

and the target point determining unit is connected with the target difference value determining unit and used for acquiring each stimulation target point, acquiring the target difference value and determining the stimulation target point corresponding to the target difference value as the target point.

7. The system of claim 1, wherein the signal acquisition module comprises: the device comprises a stimulation intensity determination unit, a transcranial magnetic stimulation instrument and an electrocardiograph; wherein,

the stimulation intensity determination unit is used for acquiring a resting motion threshold of the target object and determining the stimulation intensity of transcranial magnetic stimulation according to the resting motion threshold;

the transcranial magnetic stimulation instrument is connected with the stimulation intensity determination unit and is used for acquiring the stimulation intensity and carrying out transcranial magnetic stimulation on the target object based on the stimulation intensity, preset stimulation duration, preset stimulation intervals and at least two stimulation target points;

the electrocardiograph is used for measuring and acquiring electrocardiosignals of the target object during transcranial magnetic stimulation.

8. The system of claim 1, further comprising: a signal synchronization module; wherein,

the signal synchronization module is respectively connected with the signal acquisition module and the signal processing module, and is used for acquiring a high-frequency trigger signal when the target object is subjected to transcranial magnetic stimulation, the electrocardiosignal acquired by the signal acquisition module and an R peak detection signal in the signal processing module, and synchronizing the high-frequency trigger signal, the electrocardiosignal and the R peak detection signal according to signal acquisition time.

9. The system of claim 8, further comprising: a display module; wherein,

and the display module is connected with the signal synchronization module and is used for acquiring and displaying the synchronized high-frequency trigger signal, the electrocardiosignal and the R peak detection signal.

10. A transcranial magnetic stimulation target determination method is characterized by comprising the following steps:

based on a signal acquisition module, acquiring electrocardiosignals of a target object when the target object is subjected to transcranial magnetic stimulation through at least two stimulation target points, and sending the electrocardiosignals to a signal processing module;

based on the signal processing module, receiving the electrocardiosignals, processing the electrocardiosignals to obtain R peak detection signals, and sending the R peak detection signals to a target point determining module;

and based on the target point determination module, acquiring the R peak detection signal, and determining a target point from at least two stimulation target points for performing transcranial magnetic stimulation on the target object according to the R peak detection signal.

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