CN114778626B - Glucose sensor signal conditioning circuit - Google Patents
Glucose sensor signal conditioning circuit Download PDFInfo
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- CN114778626B CN114778626B CN202210456246.4A CN202210456246A CN114778626B CN 114778626 B CN114778626 B CN 114778626B CN 202210456246 A CN202210456246 A CN 202210456246A CN 114778626 B CN114778626 B CN 114778626B
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 60
- 239000008103 glucose Substances 0.000 title claims abstract description 60
- 230000003750 conditioning effect Effects 0.000 title claims abstract description 29
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 7
- 239000003990 capacitor Substances 0.000 claims description 31
- 230000005669 field effect Effects 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 239000008280 blood Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 15
- 238000013461 design Methods 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 230000003321 amplification Effects 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a glucose sensor signal conditioning circuit, which comprises: the glucose sensor comprises a sensor S1, a constant potential rectifier circuit, a third resistor R3, a second operational amplifier, a transimpedance amplifier circuit and a low-pass filter circuit, wherein the constant potential rectifier circuit is used for ensuring constant potential of a reference electrode RE and a counter electrode CE, the third resistor R3 is used for collecting current signals, the transimpedance amplifier circuit is used for converting current into voltage output, a negative feedback circuit is used for converting the current into amplified multiple and stabilizing effect of a current output value, the low-pass filter circuit is used for filtering high-frequency signals and clutter signals to obtain clean voltage signals Vout, and the glucose sensor can be adapted to glucose sensors with different formulas by modifying the voltage values of a first bias voltage Vref1 and a second bias voltage Vref2, so that the Vout output by the glucose sensor is in a linear range, and is beneficial to the concentration of glucose by the voltage value.
Description
Technical Field
The invention relates to the technical field of glucometer equipment, in particular to a signal conditioning circuit of a glucose sensor.
Background
The blood sugar detector is an essential tool for monitoring blood sugar of a human body, and is suitable for diabetics and pregnant women in gestation period. In the hardware circuit design of blood glucose meters, electrochemical sensors have made them a dominant choice for blood glucose meter design due to their superior performance. The design of the sensor signal conditioning circuit is particularly critical, and the sensor signal conditioning circuit is used for accurately detecting the blood sugar concentration value by the blood sugar detector and enabling the blood sugar detector to react according to the detected gas blood sugar concentration value.
In the existing design of blood glucose meter products, a signal conditioning circuit can only be applied to one blood glucose sensor, when the blood glucose sensor needs to be replaced by another sensor, and the whole signal conditioning circuit needs to be redesigned. This necessarily causes problems such as an increase in development cost and a great variety of raw materials required for designing a circuit. In addition, the design quality of the signal conditioning circuit is directly related to certain key parameters of the blood glucose meter, such as the response time.
Therefore, existing conditioning circuits are mostly unsuitable for different types of glucose electrochemical sensors. A dedicated conditioning circuit needs to be customized for different kinds of electrochemical sensors. The different bias voltages required for electrochemical sensors with different inner enzyme layers means that the conditioning circuit needs to be redesigned if the inner enzyme layer formulation of the electrochemical sensor needs to be changed.
Accordingly, the prior art is in need of improvement.
Disclosure of Invention
The conditioning circuit of the glucometer in the prior art is not suitable for different types of glucose electrochemical sensors, and further causes the problem of increased cost.
The present invention aims to at least partially alleviate or solve at least one of the above mentioned problems. The invention provides a glucose sensor signal conditioning circuit, which comprises:
a sensor S1 comprising a working electrode WE, a reference electrode RE and a counter electrode CE;
the potentiostat circuit is connected with the first bias voltage Vref1 and is used for ensuring that the potential of the reference electrode RE and the potential of the counter electrode CE are constant;
the acquisition circuit is connected with the working electrode WE and is used for acquiring current signals,
the transimpedance amplifier circuit is connected with the second bias voltage Vref2 and used for converting current into voltage output;
the negative feedback circuit is used for converting the current into amplified times and stabilizing the current output value;
the low-pass filter circuit is used for filtering the high-frequency signals and clutter signals to obtain a clean voltage signal Vout.
In one embodiment, the potentiostat circuit comprises: the first operational amplifier U1A, the first capacitor C1, the fourth capacitor C4, the first resistor R1, the fifth resistor R5, the sixth resistor R6 and the eighth resistor R8;
the positive input end of the first operational amplifier U1A is connected with the first bias voltage Vref1 through the first resistor R1;
the negative input end of the first operational amplifier U1A is sequentially connected with the sixth resistor R6, the fifth resistor R5 and the reference electrode RE;
the output end of the first operational amplifier U1A is connected to the counter electrode CE through the eighth resistor R8.
In one embodiment, the positive power supply VCC of the first operational amplifier U1A is connected to the negative power supply of the first operational amplifier U1A through a fifth capacitor C5.
In one embodiment, the acquisition circuit comprises: a third resistor R3 and a second operational amplifier U1B;
the working electrode WE is connected to the negative input end of the second operational amplifier U1B through the third resistor R3, and the third resistor R3 is used for collecting a current signal.
In one embodiment, the transimpedance amplifier circuit comprises: and the positive input end of the second operational amplifier U1B is connected with the second bias voltage Vref2 through the second resistor R2.
In one embodiment, the negative feedback circuit includes: the negative input end of the second operational amplifier U1B is respectively connected with one end of the fourth resistor R4 and one end of the second capacitor C2, and the other end of the fourth resistor R4 and the other end of the second capacitor C2 are both connected with the output end of the second operational amplifier U1B.
In one embodiment, the glucose sensor signal conditioning circuit further comprises a first field effect transistor Q1 and a sixth capacitor C6;
the source electrode S of the first field effect transistor Q1 is connected with the working electrode WE;
the drain electrode D of the first field effect transistor Q1 is connected with the reference electrode RE;
the gate G of the first fet Q1 is connected to one end of the sixth capacitor C6.
In one embodiment, the low-pass filter circuit includes a seventh resistor R7 and a third capacitor C3;
the output end of the second operational amplifier U1B is connected to the output voltage signal end Vout through the seventh resistor R7.
The other end of the sixth capacitor C6 is connected to the output voltage signal terminal Vout through the third capacitor C3.
In one embodiment, the first field effect transistor Q1 is a p-channel JFET.
In one embodiment, the second operational amplifier U1B employs an operational amplifier LPV802.
In one embodiment, the first operational amplifier U1B employs an operational amplifier LPV802.
The glucose sensor signal conditioning circuit provided by the invention has the beneficial effects that:
the invention provides a glucose sensor signal conditioning circuit, which comprises: the glucose sensor comprises a sensor S1, a constant potential rectifier circuit, a third resistor R3, a second operational amplifier, a transimpedance amplifier circuit and a low-pass filter circuit, wherein the constant potential rectifier circuit is used for ensuring constant potential of a reference electrode RE and a counter electrode CE, the third resistor R3 is used for collecting current signals, the transimpedance amplifier circuit is used for converting current into voltage output, a negative feedback circuit is used for converting the current into amplified multiple and stabilizing effect of a current output value, the low-pass filter circuit is used for filtering high-frequency signals and clutter signals to obtain clean voltage signals Vout, and the glucose sensor can be adapted to glucose sensors with different formulas by modifying the voltage values of a first bias voltage Vref1 and a second bias voltage Vref2, so that the Vout output by the glucose sensor is in a linear range, and is beneficial to the concentration of glucose by the voltage value.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments or the description of the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a signal conditioning circuit for a glucose sensor according to a preferred embodiment of the present invention.
Detailed Description
In order to make the technical problems, technical schemes and beneficial effects to be solved more clear, the invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The signal conditioning circuit in the prior art blood glucose meter is only applicable to one blood glucose sensor, when the blood glucose sensor needs to be replaced by another sensor, and the whole signal conditioning circuit needs to be redesigned, which inevitably leads to the problems of increased research and development cost, various raw materials required for designing the circuit, and the like.
Referring to fig. 1, a signal conditioning circuit of a glucose sensor includes: the sensor S1 comprises a working electrode WE, a reference electrode RE and a counter electrode CE, the potentiostat circuit is connected with a first bias voltage Vref1 and used for guaranteeing constant potential of the reference electrode RE and the counter electrode CE, the acquisition circuit is connected with the working electrode WE and used for acquiring current signals, the transimpedance amplifier circuit is connected with a second bias voltage Vref2 and used for converting current into voltage output, the negative feedback circuit is used for converting current into amplified multiple and stabilizing effect of current output value, and the low-pass filter circuit is used for filtering high-frequency signals and clutter signals and obtaining clean voltage signals Vout. The invention can adapt to glucose sensors with different formulas by modifying the voltage values of the first bias voltage Vref1 and the second bias voltage Vref2, so that the output Vout of the glucose sensors is in a linear range, and the glucose concentration can be reversely deduced by the voltage value
Preferably, the potentiostat circuit comprises: the first operational amplifier U1A, the first capacitor C1, the fourth capacitor C4, the first resistor R1, the fifth resistor R5, the sixth resistor R6 and the eighth resistor R8;
the positive input end of the first operational amplifier U1A is connected with the first bias voltage Vref1 through the first resistor R1;
the negative input end of the first operational amplifier U1A is sequentially connected with the sixth resistor R6, the fifth resistor R5 and the reference electrode RE;
the output end of the first operational amplifier U1A is connected to the counter electrode CE through the eighth resistor R8.
Preferably, the positive power supply VCC of the first operational amplifier U1A is connected to the negative power supply of the first operational amplifier U1A through a fifth capacitor C5.
Preferably, the acquisition circuit includes: a third resistor R3 and a second operational amplifier U1B;
the working electrode WE is connected to the negative input end of the second operational amplifier U1B through the third resistor R3, and the third resistor R3 is used for collecting a current signal.
Preferably, the transimpedance amplifier circuit includes: and the positive input end of the second operational amplifier U1B is connected with the second bias voltage Vref2 through the second resistor R2.
Preferably, the negative feedback circuit includes: the negative input end of the second operational amplifier U1B is respectively connected with one end of the fourth resistor R4 and one end of the second capacitor C2, and the other end of the fourth resistor R4 and the other end of the second capacitor C2 are both connected with the output end of the second operational amplifier U1B. The resistance of the fourth resistor R4 and the capacitance of the second capacitor C2 determine the amplification factor and the stabilizing effect of the circuit output value, the resistance of the fourth resistor R4 determines the amplification factor after the current is converted, and the second capacitor C2 is used for filtering the ac part in the current signal.
Preferably, the glucose sensor signal conditioning circuit further includes a first field effect transistor Q1 and a sixth capacitor C6;
the source electrode S of the first field effect transistor Q1 is connected with the working electrode WE;
the drain electrode D of the first field effect transistor Q1 is connected with the reference electrode RE;
the gate G of the first fet Q1 is connected to one end of the sixth capacitor C6.
Preferably, the low-pass filter circuit includes a seventh resistor R7 and a third capacitor C3, for filtering out high-frequency signals and clutter signals to obtain a clean voltage signal Vout;
the output end of the second operational amplifier U1B is connected to the output voltage signal end Vout through the seventh resistor R7.
The other end of the sixth capacitor C6 is connected to the output voltage signal terminal Vout through the third capacitor C3.
Preferably, the first field effect transistor Q1 is a p-channel JFET.
Preferably, the second operational amplifier U1B employs an operational amplifier LPV802.
Preferably, the first operational amplifier U1B employs an operational amplifier LPV802.
In this embodiment, the first bias voltage Vref1 and the second bias voltage Vref2 may be output by using a DAC port of the single-chip microcomputer, and the voltage signal thereof may be directly measured by using a multimeter, or may be collected by using an ADC in the single-chip microcomputer system.
In this example, the voltage value after conversion from the corresponding electrochemical sensor S1 of the glucose solution with the concentration of x mmol/L can be calculated as follows:
conversion voltage value v=ref+s×x×y for glucose solution of x mmol/L concentration
Wherein x is the concentration of the glucose solution, and the unit is mmol/L; s is the sensitivity of the electrochemical sensor (the magnitude of the current response value caused by glucose in unit concentration, and the unit is nA/mmol multiplied by L-1); y is the resistance value of the feedback fourth resistor R4, the unit is ohm (omega), and Ref is the voltage magnitude of the second bias voltage Vref2, the unit is volt (V).
Because the manufacturing processes of the glucose electrochemical sensor are different, namely, the enzyme layer formulas on the working electrode WE are different, the redox potential differences of the glucose sensors of different types are different, and the bias voltage value is also modified in order to enable the current response of the glucose sensor to be in a linear range. According to the invention, through modifying the voltage values of the first bias voltage Vref1 and the second bias voltage Vref2, glucose sensors with different formulas can be adapted, so that the output Vout of the glucose sensors is in a linear range, and the glucose concentration can be reversely pushed by the voltage value.
In this embodiment, glucose concentration measurements of different concentration levels may be adapted by modifying the resistance value of the fourth resistor R4.
In this embodiment, the sensor S1 is a glucose electrochemical sensor based on glucose oxidase. May be adapted to other gas sensors, such as (CO, NO, NH3, etc.), wherein the glucose sensor in the present invention is preferably a secondary oxidase type sensor,
in this embodiment, the first operational amplifier U1A and the second operational amplifier U1B form a dual-channel operational amplifier, wherein the first operational amplifier U1A and the second operational amplifier U1B can each use the LPV802 with the model TI.
In this embodiment, the first fet Q1 is a p-channel JFET, which is used to prevent polarization of the sensor S1, reduce response time, and quickly respond after power-on, and start operation.
In this embodiment, the potential difference between the first bias voltage Vref1 and the second bias voltage Vref2 may be implemented by using a voltage divider circuit, or may be provided by using a DAC of a single-chip microcomputer, for example, a single-chip microcomputer with a model STM32RCT 6; the voltage acquisition of Vout can also be performed using a high-precision analog-to-digital conversion chip.
In summary, the present invention provides a glucose sensor signal conditioning circuit, which includes: the glucose sensor comprises a sensor S1, a constant potential rectifier circuit, a third resistor R3, a second operational amplifier, a transimpedance amplifier circuit and a low-pass filter circuit, wherein the constant potential rectifier circuit is used for ensuring constant potential of a reference electrode RE and a counter electrode CE, the third resistor R3 is used for collecting current signals, the transimpedance amplifier circuit is used for converting current into voltage output, a negative feedback circuit is used for converting the current into amplified multiple and stabilizing effect of a current output value, the low-pass filter circuit is used for filtering high-frequency signals and clutter signals to obtain clean voltage signals Vout, and the glucose sensor can be adapted to glucose sensors with different formulas by modifying the voltage values of a first bias voltage Vref1 and a second bias voltage Vref2, so that the Vout output by the glucose sensor is in a linear range, and is beneficial to the concentration of glucose by the voltage value.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.
Claims (6)
1. A glucose sensor signal conditioning circuit, comprising:
a sensor S1 comprising a working electrode WE, a reference electrode RE and a counter electrode CE;
a potentiostat circuit connected to the first bias voltage Vref1 for ensuring constant potentials of the reference electrode RE and the counter electrode CE, the potentiostat circuit comprising: the first operational amplifier U1A, the first capacitor C1, the fourth capacitor C4, the first resistor R1, the fifth resistor R5, the sixth resistor R6 and the eighth resistor R8; the positive input end of the first operational amplifier U1A is connected with the first bias voltage Vref1 through the first resistor R1; the negative input end of the first operational amplifier U1A is sequentially connected with the sixth resistor R6, the fifth resistor R5 and the reference electrode RE; the output end of the first operational amplifier U1A is connected with the counter electrode CE through the eighth resistor R8;
the acquisition circuit, the acquisition circuit with working electrode WE is connected for gather the current signal, the acquisition circuit includes: a third resistor R3 and a second operational amplifier U1B; the working electrode WE is connected with the negative input end of the second operational amplifier U1B through the third resistor R3, and the third resistor R3 is used for collecting current signals;
a transimpedance amplifier circuit connected to a second bias voltage Vref2 for converting a current into a voltage output, the transimpedance amplifier circuit comprising: the positive input end of the second operational amplifier U1B is connected with the second bias voltage Vref2 through the second resistor R2;
a negative feedback circuit for current conversion to a post-amplified multiple and a stabilizing effect of a current output value, the negative feedback circuit comprising: the negative input end of the second operational amplifier U1B is respectively connected with one end of the fourth resistor R4 and one end of the second capacitor C2, and the other end of the fourth resistor R4 and the other end of the second capacitor C2 are both connected with the output end of the second operational amplifier U1B;
the low-pass filter circuit is used for filtering the high-frequency signals and clutter signals to obtain clean voltage signals Vout;
the first bias voltage Vref1 and the second bias voltage Vref2 are output by using a DAC port of the singlechip, or voltage signals of the first bias voltage Vref1 and the second bias voltage Vref2 are directly measured by using a universal meter, or are acquired by using an ADC in the singlechip system.
2. The glucose sensor signal conditioning circuit of claim 1, wherein the positive power supply VCC of the first operational amplifier U1A is connected to the negative power supply of the first operational amplifier U1A through a fifth capacitor C5.
3. The glucose sensor signal conditioning circuit of claim 1, further comprising a first field effect transistor Q1 and a sixth capacitance C6;
the source electrode S of the first field effect transistor Q1 is connected with the working electrode WE;
the drain electrode D of the first field effect transistor Q1 is connected with the reference electrode RE;
the gate G of the first fet Q1 is connected to one end of the sixth capacitor C6.
4. The glucose sensor signal conditioning circuit of claim 3, wherein the low pass filter circuit comprises a seventh resistor R7 and a third capacitor C3;
the output end of the second operational amplifier U1B is connected with an output voltage signal end Vout through the seventh resistor R7;
the other end of the sixth capacitor C6 is connected to the output voltage signal terminal Vout through the third capacitor C3.
5. The glucose sensor signal conditioning circuit of claim 3, wherein the first field effect transistor Q1 is a p-channel JFET.
6. The glucose sensor signal conditioning circuit of claim 1, wherein the second operational amplifier U1B employs an operational amplifier LPV802.
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| CN202210456246.4A CN114778626B (en) | 2022-04-28 | 2022-04-28 | Glucose sensor signal conditioning circuit |
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| CN112334867A (en) * | 2018-05-24 | 2021-02-05 | 纽约州立大学研究基金会 | Capacitive sensor |
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