CN114732353B - High-resolution fundus optical imaging system - Google Patents
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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- G—PHYSICS
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- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B13/00—Optical objectives specially designed for the purposes specified below
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- G02B13/0015—Miniaturised objectives for electronic devices, e.g. portable telephones, webcams, PDAs, small digital cameras characterised by the lens design
- G02B13/002—Miniaturised objectives for electronic devices, e.g. portable telephones, webcams, PDAs, small digital cameras characterised by the lens design having at least one aspherical surface
- G02B13/0045—Miniaturised objectives for electronic devices, e.g. portable telephones, webcams, PDAs, small digital cameras characterised by the lens design having at least one aspherical surface having five or more lenses
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B13/00—Optical objectives specially designed for the purposes specified below
- G02B13/001—Miniaturised objectives for electronic devices, e.g. portable telephones, webcams, PDAs, small digital cameras
- G02B13/0055—Miniaturised objectives for electronic devices, e.g. portable telephones, webcams, PDAs, small digital cameras employing a special optical element
- G02B13/006—Miniaturised objectives for electronic devices, e.g. portable telephones, webcams, PDAs, small digital cameras employing a special optical element at least one element being a compound optical element, e.g. cemented elements
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B13/00—Optical objectives specially designed for the purposes specified below
- G02B13/06—Panoramic objectives; So-called "sky lenses" including panoramic objectives having reflecting surfaces
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Abstract
The invention discloses a high-resolution fundus optical imaging system, and belongs to the technical field of optical imaging. The lens comprises a plurality of lenses and an aperture diaphragm, and the lens comprises the following components in sequence from an object side to an image side: an ocular objective and secondary imaging group G1; the secondary imaging group G1 is composed of an aperture diaphragm, a fixed mirror group G2, a focusing mirror group G3 and a compensating mirror group G4, the fixed mirror group G2, the focusing mirror group G3 and the compensating mirror group G4 are respectively composed of a plurality of lenses, wherein the focal length of the fixed mirror group G2 is f2, the focal length of the compensating mirror group G4 is f3, the focal length of the whole system is f, and the following relations are required: 26.149 is less than or equal to f2/f is less than or equal to 40.223; f3/f is not less than-8.817 and is not less than-12.117. The diopter adjusting range can reach minus 20D to plus 20D, the system field angle is 50 degrees, the object space resolution can reach 0.185mm, high-resolution imaging is realized, and the acquired fundus image information is clearer and richer.
Description
Technical Field
The invention relates to the technical field of optical imaging, in particular to a fundus imaging optical imaging system technology, and more particularly to a high-resolution fundus optical imaging system.
Background
The human eye is a precise optical imaging system, and the retina is equivalent to a receiver in the optical imaging system and is crucial to acquiring external information, so that the retina is the only tissue of the whole body which can observe blood vessels and the distribution state thereof under the condition of living bodies and non-invasiveness, and becomes an important window for diagnosing eye diseases and related systemic diseases of the whole body at present. Fundus imaging is to shoot retina tissues, and the method can be used for detecting common ophthalmic diseases such as cataract, glaucoma and the like and diagnosing systemic diseases such as early hypertension, diabetes and the like.
The traditional fundus imaging system has a small visual angle which is about 40 degrees, a complex structure and a deficient diopter compensation range. The development of fundus imaging systems is more and more intensive according to different clinical requirements, and the development is generally towards large visual field, miniaturization, high resolution, low energy consumption and color imaging.
Chinese patent application No. 202110538617.9, published 2021, 08.6.3.A fundus imaging optical imaging system with large field of view and free of mydriasis and wide refraction compensation is disclosed, which comprises a net film objective lens group, a focusing lens group and an imaging lens group which are coaxially arranged from left to right, wherein primary imaging is carried out between the net film objective lens group and the focusing lens group; the omentum objective lens group is formed by combining two cemented lenses and a positive lens; the focusing lens group consists of two meniscus lenses, the imaging lens group comprises two quasi-symmetrical cemented lenses and a positive lens, and emergent rays of the positive lens vertically enter an imaging focal plane. The patent adopts a secondary imaging system design, realizes the large visual field non-mydriatic imaging of the eye fundus, can eliminate veiling glare and ghost images, has the minimum shooting pupil diameter of 2mm and the imaging visual field of up to 60 degrees, and is convenient for the diagnosis of eye diseases; however, the omentum objective lens disclosed by the patent is high in processing difficulty, the omentum objective lens adopts a 5-piece structure, the number of objective lenses is large, backscattering ghost images of a system are increased, the difficulty in elimination is high, and the complexity of the system is increased.
China patent application, application number 201810103123.6, application publication date 2018 on 06 month 5, discloses fundus imaging optical imaging system, is equipped with first battery of lenses, second battery of lenses, third battery of lenses, fourth battery of lenses and sensitization chip in proper order from the outside direction optical axis of human retina, and the image process behind first battery of lenses and the second battery of lenses first formation of image between second battery of lenses and the third battery of lenses, then the process behind third battery of lenses, fourth battery of lenses and the sensitization chip image in image plane position department for the second time. The fundus imaging optical imaging system disclosed by the patent is large in visual angle, high in resolution and convenient to operate. Although the visual field of the patent is very big, the working distance is 0, clings to the cornea, mainly aims at neonates and incompletely-developed children, and the measurement and debugging difficulty is very big, and can cause discomfort to human eyes.
Disclosure of Invention
Problems to be solved
Aiming at the problem that the field angle of the traditional fundus imaging system is generally small and is mostly about 40 degrees, the fundus optical imaging system provided by the invention has the system field angle of 50 degrees and the object space resolution of 0.185 mm; aiming at the problems that the traditional fundus imaging system is complex in structure and insufficient in diopter compensation range, the fundus optical imaging system provided by the invention has the diopter adjustment range of-20D to +20D, is wide in compensation range and meets the diopter adjustment of most human eyes.
Technical scheme
In order to solve the problems, the technical scheme adopted by the invention is as follows:
the invention discloses a high-resolution fundus optical imaging system, which comprises a plurality of lenses and an aperture diaphragm, wherein the system comprises the following components in sequence from an object side to an image side: an ocular objective and secondary imaging group G1; the secondary imaging group G1 comprises an aperture diaphragm, a fixed lens group G2, a focusing lens group G3 and a compensating lens group G4, the fixed lens group G2, the focusing lens group G3 and the compensating lens group G4 are respectively composed of a plurality of lenses, wherein the focal length of the fixed lens group G2 is f2, the focal length of the compensating lens group G4 is f3, the focal length of the whole system is f, and the following relations are required: 26.149 is less than or equal to f2/f is less than or equal to 40.223; f3/f is not less than-8.817 and is not less than-12.117. According to the system, an image is imaged for the first time at the primary image surface position after passing through the objective lens, and then imaged for the second time at the secondary image surface position after passing through the secondary imaging group G1.
Furthermore, the fixed lens group G2 of the present invention comprises a fifth lens element, a sixth lens element, a seventh lens element and an eighth lens element; the focusing lens group G3 consists of a ninth lens and a tenth lens; the compensating lens group G4 is composed of an eleventh lens element, a twelfth lens element and a thirteenth lens element. The fifth lens, the tenth lens and the twelfth lens are negative lenses; the sixth lens, the seventh lens, the eighth lens, the ninth lens, the eleventh lens, and the thirteenth lens are positive lenses.
Furthermore, in the present invention, the sixth lens element and the seventh lens element in the fixed lens group G2 are cemented together, the eleventh lens element and the twelfth lens element in the compensating lens group G4 are cemented together, and the main function of the compensating lens group G4 is to correct the residual aberration of the system.
Furthermore, the objective lens of the invention is an aspheric lens, the number of lenses is small, and ghost images of backward scattering of the objective lens are effectively reduced; the aspheric lens has a focal length f1 and a thickness d, and satisfies the following relationship:
1.553≤f1/d≤1.730。
furthermore, the primary image surface of the objective lens is located between the objective lens and the secondary imaging group G1 and is far away from the objective lens, and the distance between the primary image surface and the objective lens is more than 3.5mm, so that the interference on the final image effect caused by imaging the surface of the objective lens to the secondary image surface is avoided.
Furthermore, the system length in the present invention is TTL, which is the distance from the object side surface of the objective lens to the image plane, and satisfies the following relation:
195mm ≤ TTL≤ 205 mm。
further, the distance from the object side to the quadratic image plane of the fifth lens in the present invention is TTL1, and the following relation is satisfied:
TTL1/TTL is not less than 0.415, wherein TTL is the system length, namely the distance from the object side surface of the objective lens to the secondary image surface.
Furthermore, the total focusing stroke of the focusing lens group G3 in the present invention is x, and satisfies the following relation:
9.562mm ≤ x ≤ 10.263mm。
furthermore, the system of the invention can satisfy-20D to +20D diopter adjustment, and MTF satisfies the following magnitude relation under each diopter:
zero field of view, MTF is more than or equal to 0.1@205 lp/mm;
half field of view, MTF is more than or equal to 0.1@120 lp/mm;
the MTF is more than or equal to 0.1@80lp/mm in the full field of view.
Advantageous effects
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention can realize high-resolution fundus imaging, the object space resolution of the system can reach 0.185mm, high-resolution imaging is realized, tissues such as fundus blood vessels and the like are clearly imaged, and more convenience and accuracy are provided for clinical diagnosis.
(2) The invention can realize diopter adjustment in a large range of-20D to +20D, meets high imaging quality, basically covers diopter adjustment requirements of most of normal-vision, myopia and hypermetropia human eyes, and has higher practicability.
(3) The objective lens only uses one aspheric lens, has simple structure, effectively reduces the ghost image of the back scattering of the objective lens, and avoids the imaging of the surface of the objective lens in a system and the bringing of surface flaws into an image plane to bring bad interference to the final image, wherein the primary image plane is far away from the objective lens.
(4) The fundus imaging system can simultaneously realize high resolution, the working distance is about 30mm, and meanwhile, the large visual field (the full field angle FOV =50 degrees) under the diopter of +/-20D is met; compared with the disclosed imaging system with a large field angle, it is difficult to realize high resolution in optical design if the working distance of the conventional imaging system is about 30mm and the large field of view at ± 20D diopters is satisfied. To get a larger field of view or to reduce the working distance; or to change the optical concept, such as confocal scanning, which is completely different from the concept of the present invention. If the working distance is very small, the measurement is inconvenient, even the human eyes are uncomfortable, and the like, and the use is inconvenient.
Drawings
FIG. 1 is a diagram: the invention discloses a structural schematic diagram of a fundus optical imaging system;
FIG. 2 is a diagram: MTF plot at 0D diopter for the optical imaging system of example 1;
FIG. 3 is a diagram of: the MTF plot at-20D diopters for the optical imaging system of example 1;
FIG. 4 shows: MTF plot at +20D diopters for the optical imaging system of example 1;
FIG. 5 is a diagram: MTF plot at 0D diopter for the optical imaging system of example 2;
FIG. 6 is a diagram of: the MTF plot at-20D diopters for the optical imaging system of example 2;
FIG. 7 is a diagram of: MTF plot at +20D diopters for the optical imaging system of example 2;
FIG. 8 is a diagram of: MTF plot at 0D diopter for the optical imaging system of example 3;
FIG. 9 is a diagram of: the MTF plot at-20D diopters for the optical imaging system of example 3;
FIG. 10 is a diagram: MTF plot at +20D diopters for the optical imaging system of example 3;
in the figure: 1. a pupil; 2. an ocular objective lens; 3. a primary image plane; 4. an aperture diaphragm; 5. a fifth lens; 6. a sixth lens; 7. a seventh lens; 8. an eighth lens; 9. a ninth lens; 10. a tenth lens; 11. an eleventh lens; 12. a twelfth lens; 13. a thirteenth lens; 14. a secondary image plane;
g1, secondary imaging group; g2, a fixed mirror group; g3, a focusing mirror group; g4, compensation mirror group.
Detailed Description
The invention is further described with reference to specific examples.
As shown in figure 1, the invention provides a high-resolution fundus optical imaging system which comprises ten lenses and an aperture diaphragm, wherein a pupil 1, an ocular objective 2, a primary image plane 3, a secondary imaging group G1 and a secondary image plane 14 are arranged in sequence from an object side to an image side. The secondary imaging group G1 consists of an aperture diaphragm 4, a fixed lens group G2, a focusing lens group G3 and a compensating lens group G4, and the fixed lens group G2 consists of a fifth lens 5, a sixth lens 6, a seventh lens 7 and an eighth lens 8; the focusing mirror group G3 is constituted by a ninth lens 9 and a tenth lens 10; the compensating lens group G4 is composed of an eleventh lens element 11, a twelfth lens element 12, and a thirteenth lens element 13. The fifth lens 5, the tenth lens 10 and the twelfth lens 12 are negative lenses; the sixth lens 6, seventh lens 7, eighth lens 8, ninth lens 9, eleventh lens 11, and thirteenth lens 13 are positive lenses. Wherein, the focal length of the fixed lens group G2 is f2, the focal length of the compensating lens group G4 is f3, and the focal length of the whole system is f, which satisfies the following relations: 26.149 is less than or equal to f2/f is less than or equal to 40.223; f3/f is not less than-8.817 and is not less than-12.117. According to the system, an image is firstly imaged at the position of the primary image surface 3 after passing through the objective lens, and then is secondly imaged at the position of the secondary image surface 14 after passing through the secondary imaging group G1.
In some embodiments, the sixth lens 6 and the seventh lens 7 in the fixed lens group G2 are cemented, and the eleventh lens 11 and the twelfth lens 12 in the compensating lens group G4 are cemented.
In some embodiments, the objective lens 2 of the optical imaging system is an aspheric lens, which effectively reduces the ghost image of the backscattering of the objective lens, and the primary image plane 3 is located between the objective lens 2 and the secondary imaging group G1, and is far away from the objective lens 2, and the distance between the primary image plane 3 and the objective lens is more than 3.5mm, so as to avoid the interference of the imaging of the surface of the objective lens to the secondary image plane 14, which causes the final image effect. The focal length of the eye objective lens is f1, the thickness is d, and the following relation is satisfied:
1.553≤f1/d≤1.730。
in some embodiments, the optical imaging system of the present invention has a length TTL, which is the distance from the object-side surface of the objective lens 2 to the secondary image surface 14, and satisfies the following relationship:
195mm≤TTL≤205mm。
in some embodiments, the distance from the object side of the fifth lens 5 to the secondary image plane 14 in the optical imaging system of the present invention is TTL1, and the following relation is satisfied:
0.385≤TTL1/TTL≤0.415。
in some embodiments, the total focusing stroke of the focusing lens group G3 in the optical imaging system of the present invention is x, and satisfies the following relation:
9.562mm≤x≤10.263mm。
in some embodiments, the optical imaging system of the present invention, the photographing light source is visible light, the working wavelength is 430nm to 680nm, and the central wavelength is 587 nm; the preview light source is infrared light, and the working wavelength is 760nm-800 nm. Preferably, the preview light source is infrared light having a wavelength of 780 nm.
In some embodiments, the optical imaging system of the present invention, full field angle FOV =50 °.
In some embodiments, the optical imaging system of the present invention can satisfy the adjustment of-20D to +20D diopters, and the MTF satisfies the following magnitude relationship at each diopter:
zero field of view, MTF is more than or equal to 0.1@205 lp/mm;
half field of view, MTF is more than or equal to 0.1@120 lp/mm;
the MTF is more than or equal to 0.1@80lp/mm in the full field of view.
On the premise that the above conditions are satisfied, 3 specific embodiments are given.
Example 1
In example 1, the optical imaging system parameters satisfy the following table:
table 1 parametric conditions for the system in example 1
Additionally, f1=27.672 mm; f = -8.300; fov =50 °; TTL =200 mm; TTL1=77 mm; d =10.263 mm; FNO =5.922
FIGS. 2-4 show the MTF curves of example 1 at 0D, -20D, +20D diopters, respectively, and it can be seen that the maximum field of view of the system is 50 DEG, and zero field of view, the MTF is more than or equal to 0.1@205 lp/mm; half field of view, MTF is more than or equal to 0.1@120 lp/mm; the MTF is more than or equal to 0.1@80lp/mm in the full field of view. The smallest resolvable fundus 0.13 μm vessel detail. The system object space resolution of the embodiment can reach 0.185mm, and due to the imaging amplification effect of human eyes, the blood vessel details of 0.13 mu m of fundus can be resolved at minimum, so that high-resolution imaging is realized.
Example 2
In example 2, the optical imaging system parameters satisfy the following table:
table 2 parameter conditions for the system in example 2
Additionally, f1=25.639 mm; f = -8.300; fov =50 °; TTL =195 mm; TTL1=75 mm; d =9.562 mm; FNO =5.918
FIGS. 5-7 show the MTF curves at 0D, -20D, +20D diopters for example 2, respectively, and it can be seen that the maximum field of view of the system is 50 DEG, and zero field of view, the MTF is more than or equal to 0.1@205 lp/mm; half field of view, MTF is more than or equal to 0.1@120 lp/mm; the MTF is more than or equal to 0.1@80lp/mm in the full field of view. The minimum resolvable eyeground is 0.13 mu m of blood vessel details, and high-resolution imaging is realized.
Example 3
In example 3, the optical imaging system parameters satisfy the following table:
table 3 conditions of parameters of the system in example 3
Additionally, f1=24.855 mm; f = -8.300; fov =50 °; TTL =205 mm; TTL1=85 mm; d =9.622 mm; FNO =5.920
FIGS. 8-10 show the MTF curves at 0D, -20D, +20D diopters for example 3, respectively, and it can be seen that the maximum field of view of the system is 50 DEG, and zero field of view, the MTF is more than or equal to 0.1@205 lp/mm; half field of view, MTF is more than or equal to 0.1@120 lp/mm; the MTF is more than or equal to 0.1@80lp/mm in the whole field of view. The minimum resolvable fundus is 0.13 μm blood vessel detail, and high resolution imaging is realized.
Claims (8)
1. A high resolution fundus optical imaging system is characterized in that the system comprises a plurality of lenses and an aperture diaphragm, and the system comprises the following components in sequence from an object side to an image side: an ocular objective and secondary imaging group G1; the secondary imaging group G1 consists of an aperture diaphragm, a fixed mirror group G2, a focusing mirror group G3 and a compensating mirror group G4, and the fixed mirror group G2 consists of a fifth lens, a sixth lens, a seventh lens and an eighth lens; the focusing lens group G3 consists of a ninth lens and a tenth lens, the compensating lens group G4 consists of an eleventh lens, a twelfth lens and a thirteenth lens, the sixth lens and the seventh lens in the fixed lens group G2 are cemented, and the eleventh lens and the twelfth lens in the compensating lens group G4 are cemented; wherein, the focal length of the fixed lens group G2 is f2, the focal length of the compensating lens group G4 is f3, and the focal length of the whole system is f, which satisfies the following relations: 26.149 is less than or equal to f2/f is less than or equal to 40.223; f3/f is not less than-8.817 and is not less than-12.117; the eye objective lens is an aspheric lens, the first lens to the sixth lens are all standard lenses, and the fifth lens, the tenth lens and the twelfth lens are negative lenses; the sixth lens, the seventh lens, the eighth lens, the ninth lens, the eleventh lens, and the thirteenth lens are positive lenses.
2. The high resolution fundus optical imaging system of claim 1, wherein: the objective lens is an aspheric lens with a focal length f1 and a thickness d, and satisfies the following relation:
1.553≤f1/d≤1.730。
3. the high resolution fundus optical imaging system of claim 1 wherein: the primary image surface of the system is located between the objective lens and the secondary imaging group G1 and is far away from the objective lens, and the distance between the primary image surface and the objective lens is more than 3.5 mm.
4. The high resolution fundus optical imaging system of claim 1, wherein: the system length is TTL, namely the distance from the object side surface of the objective lens to the secondary image surface, and the following relational expression is satisfied:
195mm ≤ TTL≤ 205 mm。
5. the high resolution fundus optical imaging system of claim 1, wherein: the distance from the object side to the secondary image plane of the fifth lens is TTL1, and the following relation is satisfied:
0.385 ≤ TTL1/TTL ≤ 0.415 ，
wherein, TTL is the system length, namely the distance from the object side surface of the objective lens to the secondary image surface.
6. The high resolution fundus optical imaging system of claim 1, wherein: the total focusing stroke of the focusing mirror group G3 is x, and the following relational expression is satisfied:
9.562mm ≤ x ≤ 10.263mm。
7. the high resolution fundus optical imaging system of any of claims 1-6 wherein: the photographing light source of the optical imaging system is visible light, the working wavelength is 430nm-680nm, and the central wavelength is 587 nm; the preview light source is infrared light, and the working wavelength is 760nm-800 nm.
8. The high resolution fundus optical imaging system of claim 1, wherein: the system meets-20D to +20D diopter adjustment, and MTF meets the following size relation under each diopter:
zero field of view, MTF is more than or equal to 0.1@205 lp/mm;
half field of view, MTF is more than or equal to 0.1@120 lp/mm;
the MTF is more than or equal to 0.1@80lp/mm in the full field of view.
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| US5805349A (en) * | 1995-10-13 | 1998-09-08 | Nikon Corporation | Retrofocus type lens |
| DE10111068B4 (en) * | 2000-04-07 | 2018-01-18 | Heidelberger Druckmaschinen Ag | Roller lock for releasably securing a roller in a printing machine |
| US7286303B2 (en) * | 2005-06-21 | 2007-10-23 | Tamron Co., Ltd. | Macro lens |
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| JP2012163678A (en) * | 2011-02-04 | 2012-08-30 | Ricoh Co Ltd | Zoom lens, camera, and portable information terminal device |
| WO2014024962A1 (en) * | 2012-08-08 | 2014-02-13 | 株式会社ニコン | Zoom lens, optical device, and production method for zoom lens |
| WO2018198840A1 (en) * | 2017-04-28 | 2018-11-01 | 株式会社ニコン | Ophthalmological device |
| CN210639334U (en) * | 2019-09-30 | 2020-05-29 | 江西特莱斯光学有限公司 | Ultrathin lens of single lens reflex |
| CN211796406U (en) * | 2020-01-17 | 2020-10-30 | 福建福特科光电股份有限公司 | Portable fundus imaging device |
| CN112433341A (en) * | 2020-10-21 | 2021-03-02 | 舜宇光学(中山)有限公司 | Imaging system |
| CN112630935B (en) * | 2020-12-28 | 2024-08-27 | 厦门力鼎光电股份有限公司 | Iris recognition optical lens matched with liquid lens |
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