CN114720713A

CN114720713A - Sample analyzer and sample analyzing method

Info

Publication number: CN114720713A
Application number: CN202110012745.XA
Authority: CN
Inventors: 孙娟娟
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2021-01-06
Filing date: 2021-01-06
Publication date: 2022-07-08

Abstract

The invention relates to a sample analyzer and a sample analyzing method. The sample analyzer is provided with a sample sucking station, a cleaning station and a sample adding station, and further comprises a controller, a sample dispensing mechanism and a cleaning mechanism, wherein the sample dispensing mechanism comprises a sample needle and a driving assembly; the controller controls the sample needle to suck a first preset amount of samples to be detected at the sample sucking station, controls the cleaning mechanism to clean the outer wall of the sample needle at the cleaning station after controlling the sample needle to discharge a second preset amount of samples to be detected, and controls the cleaned sample needle to inject a third preset amount of samples to be detected into a reaction container of the sample adding station, wherein the second preset amount is smaller than the first preset amount, and the third preset amount is smaller than or equal to the difference between the first preset amount and the second preset amount. So as to reduce the influence of the interfering substance on the accuracy of the detection result.

Description

Sample analyzer and sample analyzing method

Technical Field

The invention relates to the technical field of sample detection equipment, in particular to a sample analyzer and a sample analysis method.

Background

Sample analyzers are commonly used to detect and analyze specific components contained in a sample to be tested, and during the detection process, a sample needle typically draws the sample to be tested from a sample container and injects the sample to be tested into a reaction container for subsequent testing. However, some interfering substances, such as lipoproteins and the like, which affect the detection result, may exist in the sample to be detected, and some interfering substances have a low density and are liable to float on the surface of the sample to be detected, so when the sample needle extends into the sample container to absorb the sample to be detected, these interfering substances are liable to be sucked or adhered to the outer wall of the sample needle together with the sample needle, so that when the sample needle injects the sample to be detected into the reaction container, these interfering substances are brought into the reaction system together, and the accuracy of the final detection result is affected.

Disclosure of Invention

Therefore, it is necessary to provide a sample analyzer and a sample analysis method capable of reducing the influence of the interfering substance on the detection result of the sample to be detected, in order to solve the problem that the interfering substance on the outer wall of the sample needle affects the detection result.

A sample analyzer is provided with a sample sucking station, a cleaning station and a sample adding station, and further comprises a controller, a sample dispensing mechanism and a cleaning mechanism, wherein the sample dispensing mechanism is electrically connected with the controller and comprises a sample needle and a driving assembly in transmission connection with the sample needle, and the controller controls the driving assembly to drive the sample needle to move among the sample sucking station, the cleaning station and the sample adding station;

the controller controls the sample needle to suck a first preset amount of samples to be detected at the sample sucking station, controls the cleaning mechanism to clean the outer wall of the sample needle at the cleaning station after controlling the sample needle to discharge a second preset amount of samples to be detected, and controls the cleaned sample needle to inject a third preset amount of samples to be detected into a reaction container of the sample adding station, wherein the second preset amount is smaller than the first preset amount, and the third preset amount is smaller than or equal to the difference between the first preset amount and the second preset amount.

In one embodiment, after the controller controls the sample needle to discharge the third preset amount of sample to be measured, the controller further controls the cleaning mechanism to clean the inner wall and the outer wall of the sample needle at the cleaning station.

In one embodiment, the cleaning mechanism comprises a first cleaning pool, a second cleaning pool and a cleaning pipeline, wherein the first cleaning pool and the second cleaning pool are used for cleaning the outer wall of the sample needle, the cleaning pipeline is communicated with the sample needle, and cleaning liquid flows into the sample needle through the cleaning pipeline;

after the controller controls the sample needle to discharge the second preset amount of sample to be measured, the controller controls the first cleaning pool to clean the outer wall of the sample needle;

after the controller controls the sample needle to discharge the third preset amount of sample to be measured, the controller controls the second cleaning pool to clean the outer wall of the sample needle, and controls the cleaning pipeline to clean the inner wall of the sample needle.

In one embodiment, the cleaning mechanism comprises a first cleaning pool and a cleaning pipeline, the first cleaning pool is used for cleaning the outer wall of the sample needle, the cleaning pipeline is communicated with the sample needle, and cleaning liquid flows into the sample needle through the cleaning pipeline;

after the controller controls the sample needle to discharge the third preset amount of sample to be measured, the controller controls the first cleaning pool to clean the outer wall of the sample needle, and controls the cleaning pipeline to clean the inner wall of the sample needle.

In one embodiment, the first cleaning cell has a first cleaning position and a second cleaning position, the controller controls the sample needle discharging the second preset amount of the sample to be measured to clean the outer wall at the first cleaning position, the controller controls the sample needle discharging the third preset amount of the sample to be measured to clean the outer wall and the inner wall at the second cleaning position, and the first cleaning position is higher than the second cleaning position.

In one embodiment, the sample analyzer further comprises a liquid discharge station provided with a liquid discharge container, and the sample needle discharges the second preset amount of the sample to be tested to the liquid discharge container;

or the sample needle discharges the second preset amount of sample to be measured into the cleaning mechanism at the cleaning station.

In one embodiment, the controller controls the sample needle to suck a first preset volume of air after sucking a first preset amount of sample to be measured at the sample sucking station;

after the sample needle discharges the second preset amount of sample to be detected, the controller further controls the sample needle to suck a second preset volume of air;

after the sample needle discharges the third preset amount of sample to be measured, the controller further controls the sample needle to suck a third preset volume of air.

In one embodiment, the controller is further configured to obtain a detection item of a sample to be detected, and control a sample application operation of the sample needle according to the detection item of the sample to be detected, where the sample application operation of the sample needle includes: the sample needle sucks a first preset amount of samples to be detected at the sample sucking station; the sample needle discharges a second preset amount of samples to be detected; the cleaning mechanism cleans the outer wall of the sample needle at the cleaning station; moving the cleaned sample needle to the sample adding station, and adding a third preset amount of sample to be detected into the reaction container;

or, the sample adding operation of the sample needle comprises: and the sample needle directly moves to the sample adding station after sucking the sample to be detected at the sample sucking station, and injects the sample to be detected into the reaction container. .

In one embodiment, the sample analyzer further includes a sample transport mechanism for transporting a sample to be measured, a reagent dispensing mechanism for transferring a reagent, a reaction mechanism for incubating a reaction solution formed by mixing the sample to be measured with the reagent, a reagent storage mechanism for storing the reagent, a transfer mechanism for transferring the reaction container, and a sample measurement mechanism for measuring the sample to be measured.

A sample analysis method for use with a sample analyzer, the sample analysis method comprising the steps of:

the sample needle sucks a first preset amount of samples to be detected at a sample sucking station;

the sample needle discharges a second preset amount of samples to be detected;

the cleaning mechanism cleans the outer wall of the sample needle at a cleaning station;

moving the cleaned sample needle to a sample adding station, and adding a third preset amount of sample to be detected into the reaction container;

and measuring the sample to be measured in the reaction container.

In one embodiment, after the step of moving the cleaned sample needle to the loading station and adding the third preset amount of the sample to be tested to the reaction container, the sample analysis method further comprises the following steps:

the cleaning mechanism cleans the outer wall and the inner wall of the sample needle at the cleaning station.

In one embodiment, the sample analysis method further comprises the steps of:

after the sample needle discharges the second preset amount of sample to be measured, the cleaning mechanism cleans the outer wall of the sample needle at a first cleaning position;

after the sample needle discharges the third preset amount of sample to be measured, the cleaning mechanism cleans the outer wall and the inner wall of the sample needle at a second cleaning position;

the first cleaning position is higher than the second cleaning position.

In one embodiment, the method for discharging the second preset amount of the sample to be measured by the sample needle specifically includes the following steps:

the sample needle moves to a liquid discharge station, and discharges the second preset amount of sample to be detected into a liquid discharge container of the liquid discharge station;

In one embodiment, the sample analysis method further comprises the steps of:

after the sample needle sucks the first preset amount of samples to be detected at the sample sucking station, sucking air with a first preset volume;

after the sample needle discharges the second preset amount of sample to be detected, sucking air with a second preset volume;

and after the third preset amount of sample to be detected is added into the reaction container by the sample needle, sucking a third preset volume of air.

A method of sample analysis comprising the steps of:

obtaining detection items of a sample to be detected;

determining the sample adding operation of the sample needle according to the detection items of the sample to be detected;

measuring a sample to be measured;

when the detection item of the sample to be detected meets a preset condition, the sample adding operation of the sample needle comprises the following steps: the sample needle sucks a first preset amount of samples to be detected at a sample sucking station; the sample needle discharges a second preset amount of samples to be detected; the cleaning mechanism cleans the outer wall of the sample needle at a cleaning station; moving the cleaned sample needle to a sample adding station, and adding a third preset amount of sample to be detected into the reaction container;

when the detection item of the sample to be detected does not meet the preset condition, the sample adding operation of the sample needle comprises the following steps: and the sample needle directly moves to the sample adding station after sucking the sample to be detected at the sample sucking station, and injects the sample to be detected into the reaction container.

After the technical scheme is adopted, the invention at least has the following technical effects:

according to the sample analyzer and the sample analyzing method, when a sample to be detected is detected, the controller controls the sample needle to absorb the sample to be detected with a first preset amount at the sample absorbing station, and after the controller controls the sample needle to discharge the sample to be detected with a second preset amount, the controller controls the cleaning mechanism of the cleaning station to clean the outer wall of the sample needle so as to remove interfering substances attached to the outer wall of the sample needle. And the controller controls the sample needle to discharge a second preset amount of sample to be measured, and then the controller can discharge the interfering substances at the tip of the sample needle. Therefore, when the controller controls the sample needle to add a third preset amount of sample to be detected to the reaction container at the sample adding station, because the outer wall of the sample needle is cleaned, the interference substance at the needle point of the sample needle is discharged, the interference substance attached to the outer wall of the sample needle and the interference substance at the needle point of the sample needle cannot enter the reaction container again, the influence of the interference substance on the accuracy of the detection result is reduced, the problem that the interference substance on the outer wall of the sample needle influences the detection result at present is effectively solved, and the accuracy of the detection result of the sample to be detected is ensured.

Drawings

FIG. 1 is a block diagram of a sample analyzer according to an embodiment of the present invention;

FIG. 2 is a top view of the sample analyzer shown in FIG. 1;

FIG. 3 is a schematic view of the sample analyzer of FIG. 2 with the sample needle extended into a first wash position of the first wash reservoir;

FIG. 4 is a schematic view of the sample analyzer of FIG. 2 with the sample needle extended into the first wash chamber in a second wash position;

FIG. 5 is a schematic view of the first cleaning tank shown in FIG. 4;

FIG. 6 is a schematic diagram of the sample dispensing mechanism in the sample analyzer of FIG. 2 in cooperation with a controller and a first wash tank;

FIG. 7 is a schematic diagram of the sample analyzer shown in FIG. 2 illustrating the process of performing a sample loading operation;

FIG. 8 is a flowchart of a sample analysis method according to an embodiment of the invention.

Wherein: A. a sample analyzer; 10. a functional module; 110. a sample transport mechanism; 120. a sample dispensing mechanism; 121. a sample needle; 122. a drive assembly; 130. a reagent storage mechanism; 140. a reagent dispensing mechanism; 150. a reaction mechanism; 160. a sample measuring mechanism; 170. a first cleaning tank; 171. cleaning the pool body; 172. a nozzle; 173. cleaning a pipeline; 174. a first on-off valve; 175. a second on-off valve; 20. an input module; 30. a display module; 40. a memory; 50. a controller; 60. and an alarm module.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature "under," "beneath," and "under" a second feature may be directly under or obliquely under the second feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.

Referring to fig. 1 and 2, the present invention provides a sample analyzer a. The sample analyzer A is used for analyzing and detecting a sample to be detected to obtain a corresponding detection result, and the use requirement is met. It should be noted that the specific type of the sample to be tested is not limited, and in some embodiments, the sample to be tested includes a solid sample or a liquid sample. It can be understood that the liquid sample needs to be placed on the sample holder for detection. Further liquid samples include, but are not limited to, blood samples. When the sample analyzer a of the present invention is used to test a blood sample, the blood sample is stored in a test tube and sequentially placed on a test tube rack.

It can be understood that, at present, interfering substances which affect the detection result exist in the sample to be detected. When the sample needle sucks a sample to be measured, the interfering substance is sucked by the sample needle or adheres to the outer wall of the sample needle. When the sample needle injects the sample to be detected into the reaction container, an interfering substance is brought into the reaction system, and the accuracy of the detection result is affected.

To this end, the present invention provides a novel sample analyzer a. The sample analyzer a can clean the outer wall of the sample needle 121 and reduce interfering substances in a sample to be measured. Therefore, after the sample to be detected is added into the reaction container, the influence of interference substances on the detection result of the sample to be detected can be reduced, and the accuracy of the detection result of the sample to be detected is ensured. The specific structure of the sample analyzer a is described below.

Referring to fig. 1, in one embodiment, a sample analyzer a includes at least one functional module 10 (or one or more functional modules 10), an input module 20, a display module 30, a memory 40, a controller 50, and an alarm module 60, each described below. Each functional module 10 is used for performing at least one function required in the sample analysis process, and the functional modules 10 cooperate together to perform the sample analysis to obtain the result of the sample analysis. Referring to fig. 2, a sample analyzer a according to an embodiment is shown, in which some examples are given to the functional module 10.

Referring to fig. 2, for example, the functional module 10 may include a sample transport mechanism 110, a sample dispensing mechanism 120, a reagent storage mechanism 130, a reagent dispensing mechanism 140, a transfer mechanism (not shown), a reaction mechanism 150, a sample measurement mechanism 160, and the like. The sample transport mechanism 110 is used for transporting a sample to be tested, the reagent dispensing mechanism 140 is used for transferring a reagent, the reaction mechanism 150 is used for incubating a reaction solution formed by mixing the sample to be tested and the reagent, the reagent storage mechanism 130 is used for storing the reagent, the transfer mechanism is used for transferring a reaction container, and the sample determination mechanism 160 is used for determining the sample to be tested. For example, in other embodiments of the present invention, the functional module 10 may further include a reaction vessel conveying mechanism or the like.

The sample transport mechanism 110 is used to transport a sample to be tested. The sample transport mechanism 110 can transport a sample tube of a sample to be tested to a predetermined position, and the sample dispensing mechanism 120 can suck the sample to be tested in the sample tube. In some examples, the Sample transport mechanism 110 may include a Sample Delivery Module (SDM) and a front end rail; in other examples, the sample transport mechanism 110 may be a sample tray that includes a plurality of sample sites for placing samples, such as sample tubes, and the sample tray may be configured to transport the samples to corresponding locations by rotating the tray, such as locations for the sample dispensing mechanism 120 to aspirate the samples.

Referring to fig. 2 and 6, the sample dispensing mechanism 120 is used to suck a sample to be measured and discharge the sample into a reaction vessel to be loaded. For example, the sample dispensing mechanism 120 may include a sample needle 121 and a drive unit 122 connected to the sample needle 121. The drive assembly 122 is capable of outputting two-dimensional or three-dimensional motion. The sample needle 121 is spatially moved in two or three dimensions by the two or three dimensional driving assembly 122, so that the sample needle 121 can be moved to suck a sample to be measured carried by the sample transport mechanism and to a reaction container to be loaded with the sample, and discharge the sample to the reaction container.

Referring to fig. 2, the reagent storage mechanism 130 is used to store reagents. It can be understood that in the process of performing sample analysis on a sample to be detected, a reagent needs to be added, so that the sample to be detected can generate a corresponding reaction, and the later-stage sample detection is facilitated. The reagent storage mechanism 130 stores various reagents required for testing the sample to be tested. In one embodiment, the reagent storage mechanism 130 may be a reagent disk, the reagent disk is configured in a disk-shaped structure and has a plurality of positions for carrying reagent containers, and the reagent storage mechanism 130 can rotate and drive the reagent containers carried by the reagent storage mechanism to rotate to a specific position, for example, a position for sucking reagent by the reagent dispensing mechanism 140. The number of the reagent storage mechanism 130 may be one or more.

The reagent dispensing mechanism 140 is used to aspirate and discharge a reagent into a reaction vessel to which the reagent is to be added. In one embodiment, the reagent dispensing mechanism 140 may include a reagent needle and a motion mechanism coupled to the reagent needle. The motion mechanism is capable of outputting two-dimensional or three-dimensional motion. The reagent needle performs a two-dimensional or three-dimensional motion in space by a two-dimensional or three-dimensional motion assembly, so that the reagent needle can move to suck the reagent carried by the reagent storage mechanism 130 and to the reaction container to which the reagent is to be added, and discharge the reagent to the reaction container.

The reaction mechanism 150 has at least one placement position for placing a reaction vessel and incubating a reaction solution in the reaction vessel. The reaction solution herein refers to a solution formed by adding a sample to be measured and a reagent to a reaction vessel. For example, the reaction mechanism 150 may be a reaction tray, which is configured in a disc-shaped structure and has one or more placing positions for placing reaction containers, and the reaction tray can rotate and drive the reaction containers in the placing positions to rotate, so as to schedule the reaction containers in the reaction tray and incubate the reaction solutions in the reaction containers.

The sample measuring unit 160 is configured to perform optical measurement on the incubated reaction solution to obtain reaction data of the sample. Alternatively, the sample measuring means 160 includes a photodetector that detects the light emission intensity of the reaction solution to be measured, and calculates the concentration of the component to be measured in the sample from the calibration curve. Of course, in another embodiment of the present invention, the sample measuring mechanism 160 further includes a magnetic bead detection unit or the like.

Alternatively, the sample measuring section 160 is separately provided outside the reaction section 150. Of course, in the embodiment of the present invention, the sample measuring unit 160 may be disposed inside the reaction unit 150.

Referring to fig. 2, in an embodiment, the sample analyzer a further includes a test bench, the sample transport mechanism 110, the sample dispensing mechanism 120, the reagent storage mechanism 130, the reagent dispensing mechanism 140, the transfer mechanism, the reaction mechanism 150, and the sample measurement mechanism 160 are disposed on the test bench, and the controller 50 is disposed in the test bench and electrically connected to the sample transport mechanism 110, the sample dispensing mechanism 120, the reagent storage mechanism 130, the reagent dispensing mechanism 140, the transfer mechanism, the reaction mechanism 150, and the sample measurement mechanism 160, respectively, to control the operation of each mechanism.

The reaction mechanism 150 and the sample transport mechanism 110 are located on the movement locus of the sample dispensing mechanism 120, the reaction mechanism 150 and the reagent storage mechanism 130 are located on the movement locus of the reagent dispensing mechanism 140, and a certain distance exists between the movement loci of the sample dispensing mechanism 120 and the reagent dispensing mechanism 140, so that interference between the sample dispensing mechanism 120 and the reagent dispensing mechanism 140 is avoided, and reliable operation of the sample dispensing mechanism 120 and the reagent dispensing mechanism 140 is ensured.

The sample measuring unit 160 is disposed outside the reaction unit 150, so that the reaction container incubated by the reaction unit 150 can be directly transferred to the sample measuring unit 160, and the transfer path can be shortened. The transfer mechanism is movably disposed above the reaction mechanism 150 and the sample measuring mechanism 160 for effecting transfer of the reaction container between the reaction mechanism 150 and the sample measuring mechanism 160.

Further, the sample analyzer a has a disposal station for storing the reaction containers to be disposed of after the detection by the sample measuring unit 160. The transfer mechanism can also move to a discarding station to realize the transfer of the reaction container. Further, when the sample analyzer a has a reaction container carrying mechanism, the transfer mechanism can also be moved to the reaction container carrying mechanism. The reaction container transfer mechanism can store unused reaction containers, and the transfer mechanism can transfer the reaction containers in the reaction container transfer mechanism to the reaction mechanism 150. Optionally, the reaction vessel is a reaction cup. Of course, in other embodiments of the present invention, the reaction container may also be other components capable of carrying the sample to be tested and performing the later detection, such as a slide.

In use of the sample analyzer a of the present invention, the sample transport mechanism 110 transports a sample tube to be tested, and sucks a sample to be tested in the sample tube by the sample needle 121, and then the sample needle 121 adds the sample to be tested to the reaction vessel. After the reagent needle sucks up the reagent in the reagent storage mechanism 130, the reagent is added to the reaction vessel. It is understood that the reagent needle adds a reagent to the reaction vessel before or after the sample needle 121, depending on the test items of the sample to be tested.

After the sample to be detected and the reagent are added into the reaction container, the sample to be detected and the reagent form a reaction solution in the reaction container. The reaction mechanism 150 performs an incubation reaction on the reaction solution in the reaction vessel. After the incubation is completed, the transfer mechanism transfers the incubated reaction container from the reaction mechanism 150 to the sample measurement mechanism 160, and the sample measurement mechanism 160 measures the reaction solution to obtain the relevant parameters of the sample to be measured. The reaction container measured by the sample measuring unit 160 is transferred and discarded by the transfer unit.

Referring to fig. 2, 6 and 7, in an embodiment, the sample analyzer a has a sample sucking station, a cleaning station and a sample adding station, and further includes a controller 50, a sample dispensing mechanism 120 electrically connected to the controller 50, and a cleaning mechanism, wherein the sample dispensing mechanism 120 includes a sample needle 121 and a driving assembly 122 drivingly connected to the sample needle 121, and the controller 50 controls the driving assembly 122 to drive the sample needle 121 to move among the sample sucking station, the cleaning station and the sample adding station. The controller 50 controls the sample needle 121 to suck a first preset amount of sample to be tested at the sample sucking station, the controller 50 controls the cleaning mechanism to clean the outer wall of the sample needle 121 at the cleaning station after controlling the sample needle 121 to discharge a second preset amount of sample to be tested, the controller 50 also controls the cleaned sample needle 121 to inject a third preset amount of sample to be tested into the reaction container at the sample adding station, the second preset amount is smaller than the first preset amount, and the third preset amount is smaller than or equal to the difference value between the first preset amount and the second preset amount.

After the sample transport mechanism 110 carries the sample tube of the sample to be sucked, the sample tube to be sucked can be transported to the sample sucking station. The sample needle 121 can suck a sample to be measured in the sample tube at the sample sucking station. After the sample needle 121 finishes the sample suction, the sample transport mechanism 110 removes the sample tube after the sample suction from the sample suction station, and transports the sample tube to be detected to the sample suction station to perform the sample suction operation on the sample tube to be detected. Thus, continuous sampling by the sample needle 121 is continuously performed.

The cleaning mechanism is arranged at the cleaning station. The cleaning mechanism can clean the sample needle 121. Here, the cleaning of the cleaning mechanism may be cleaning of the outer wall of the sample needle 121; of course, the cleaning mechanism may also clean the inner wall and the outer wall of the sample needle 121, which will be described in detail later. After the sample needle 121 sucks a sample to be measured in the sample tube, the outer wall of the sample needle 121 is cleaned by the cleaning mechanism. The application of sample station is used for bearing the weight of the reaction vessel, and sample needle 121 adds the sample to be measured to the reaction vessel in application of sample station department to in the operation such as incubation and detection in later stage of carrying out.

The sample needle 121 can be movably arranged on the test bed, and respectively moves to a sample sucking station, a cleaning station and a sample adding station to perform corresponding operations. Alternatively, the sample needle 121 is rotatably disposed on the test stand, and the sample sucking station, the washing station, and the sample application station are disposed on a rotation trajectory of the sample needle 121. Moreover, the rotation of the sample needle 121 is realized by the controller 50 and the driving assembly 122, and the controller 50 can control the driving assembly 122 to rotate the sample needle 121, so that the sample needle 121 is switched to the work position. It should be noted that the sample needle 121 can be driven by a conventional driving assembly 122 to perform a rotational movement, which is not described herein again. Of course, in other embodiments of the present invention, the driving component may also drive the sample needle 121 to translate in the X-axis and Y-axis directions, so as to switch the sample needle 121.

In the present invention, only the sample needle 121 is rotated for explanation. Moreover, the driving assembly 122 can also drive the sample needle 121 to move up and down along the Z-axis direction. When the sample needle 121 moves to the sample sucking station, the cleaning station and the sample adding station to perform corresponding operations, the driving assembly 122 drives the sample rack to descend; after the corresponding operation is performed, the driving assembly 122 drives the sample needle 121 to ascend, and then the driving assembly 122 drives the sample needle 121 to switch stations. Specifically, the sample needle 121 can rotate to the sample suction station, and suck the sample to be measured in the sample tube at the sample suction station. After the sample sucking of the sample needle 121 is completed, the sample needle 121 can rotate to the cleaning station, the cleaning mechanism in the cleaning station cleans the sample needle 121, the cleaned sample needle 121 rotates to the sample adding station, and the sample to be measured is added to the reaction container at the sample adding station.

It can be understood that after the sample to be detected is stored in the sample tube, the sample to be detected may be layered in the sample tube, and generally, the sample to be detected in the sample tube may be divided into an upper layer, a middle layer and a lower layer. The middle layer sample is a better sample to be detected, and the upper layer sample has interfering substances with lower density, which affects the accuracy of the detection result of the sample to be detected. When the sample needle 121 extends into the sample tube to suck up the sample to be tested, the tip of the sample needle 121 extends into the middle layer of the sample to be tested in the sample tube. However, the sample needle 121 penetrates through the upper layer sample while penetrating into the middle layer sample, so that the outer wall of the sample needle 121 adheres to the interfering substances in the upper layer sample.

Moreover, after the sample needle 121 sucks the middle sample to be measured, the interfering substance in the upper sample gradually approaches the tip of the sample needle 121 due to the decrease of the liquid level in the sample tube. At the end period of the sample sucking of the sample needle 121, the interferent in the upper layer sample may be sucked to the needle tip position inside the sample needle 121. If the sample to be detected in the sample needle 121 is directly added into the reaction container for reaction, interfering substances are brought into the reaction system together, which affects the accuracy of the detection result of the sample to be detected.

Therefore, the sample analyzer a of the present invention performs the cleaning operation on the outer wall of the sample needle 121 before the sample needle 121 performs the sample application. Specifically, before the sample needle 121 after sample suction is moved to the sample application station, the sample needle 121 is moved to a cleaning station, and the sample needle 121 is cleaned by a cleaning mechanism in the cleaning station to remove interfering substances on the outer wall of the sample needle 121. In this way, after the sample to be measured is added to the reaction container of the sample adding station by the sample needle 121, since the interfering substance on the outer wall of the sample needle 121 is removed, the interfering substance on the outer wall is not added to the sample to be measured in the reaction container.

Moreover, since the interfering substance is also present in the sample to be measured at the tip position of the sample needle 121, in order to reduce the interfering substance in the sample needle 121, the sample analyzer a of the present application discharges a portion of the sample to be measured from the sample needle 121 by the controller 50 before the cleaning mechanism cleans the outer wall of the sample needle 121, so as to discharge the interfering substance at the tip position of the sample needle 121. This can reduce the amount of interfering substances in the sample to be tested. When the sample needle 121 adds a sample to be detected to the reaction container at the sample adding station, the content of interference substances in the reaction container can be reduced as much as possible, so that the interference of the interference substances to the detection process of the sample to be detected is reduced, and the accuracy of the detection result of the sample to be detected is ensured.

When the sample analyzer a of the present invention is in use, the controller 50 drives the sample needle 121 to move to the sample suction station through the driving assembly 122, and then controls the sample needle 121 to extend into the sample container at the sample suction station, so as to suck a first preset amount of sample to be measured. After the sample suction of the sample needle 121 is completed, the controller 50 controls the sample needle 121 to move upward to move out of the sample tube. Subsequently, the controller 50 controls the sample needle 121 to discharge a second preset amount of the sample to be measured to discharge the sample to be measured containing the interfering substance at the needle tip position of the sample needle 121.

Then, the controller 50 controls the sample needle 121 at the cleaning station, and controls the cleaning mechanism to clean the outer wall of the sample needle 121 to remove the interfering substances on the outer wall of the sample needle 121. After the cleaning of the outer wall of the sample needle 121 is completed, the controller 50 controls the sample needle 121 to move to the sample application station through the driving assembly 122, and controls the sample needle 121 to inject a third preset amount of the sample to be measured into the reaction container. Thus, the sample application operation is completed, and then, the reaction vessel is followed by the detection processing at the later stage.

Moreover, the second predetermined amount is less than the first predetermined amount. Therefore, the excessive samples to be detected discharged by the sample needle 121 can be avoided, and the residual samples to be detected in the sample needle 121 can meet the sample detection requirement in the later period. Moreover, after the sample needle 121 discharges the internal sample to be detected containing the interfering substance, the content of the interfering substance in the sample to be detected can be reduced, thereby reducing the influence of the interfering substance on the detection process of the sample to be detected and ensuring the accuracy of the detection result of the sample to be detected.

The third preset amount is less than or equal to the difference between the first preset amount and the second preset amount. It can be understood that, after the sample needle 121 first discharges the sample to be tested containing the interfering substance at the tip portion, the remaining sample to be tested may be used for the test in whole or in part. The sample needle 121 can be controlled to add the sample according to the required amount of the actual test items of the sample to be tested. Of course, in other embodiments of the present invention, a plurality of reaction containers may be disposed at the sample adding station, and the controller 50 may control the sample needle 121 to add the sample to be tested to the plurality of reaction containers, respectively, so as to perform different item tests on the sample to be tested.

In the sample analyzer a of the above embodiment, the sample needle 121 after the sample is sucked is controlled to discharge the second preset amount of sample to be measured, and the cleaning mechanism is controlled to clean the outer wall of the sample needle 121, so as to reduce the interfering substances carried by the sample needle 121. Therefore, after the sample to be detected is added to the reaction container by the cleaned sample needle 121 at the sample adding station, the interference substance attached to the outer wall of the sample needle 121 and the interference substance at the needle point of the sample needle 121 cannot enter the reaction container again, the influence of the interference substance on the accuracy of the detection result is reduced, the problem that the interference substance on the outer wall of the sample needle influences the detection result at present is effectively solved, and the accuracy of the detection result of the sample to be detected is ensured.

In one embodiment, the sample application station is disposed on the reaction mechanism 150. That is, the reaction mechanism 150 has a sample application station inside, and the sample needle 121 applies a sample to be measured to the reaction container at the sample application station in the reaction mechanism 150. The sample application station is a fixed location in the reaction mechanism 150. The reaction tray of the reaction mechanism 150 can carry the reaction container and drive the reaction container to move to the sample application station. At this time, the controller 50 can control the sample needle 121 to add a third preset amount of the sample to be measured into the reaction container. After the sample is added, the reaction tray of the reaction mechanism 150 drives the reaction container to rotate, the reaction container is removed, and the next reaction container to be added with the sample to be tested is moved to the sample adding station.

In one embodiment, the sample application station is disposed outside of the reaction mechanism 150. That is, the sample application station is provided separately from the reaction mechanism 150, as two distinct components. After the controller 50 controls the sample needle 121 to add a third preset amount of sample to be tested to the reaction container at the sample adding station, the controller 50 controls the transfer mechanism to transfer the reaction container after sample adding to the reaction mechanism 150, and the reaction mechanism 150 incubates the reaction solution in the reaction container.

Optionally, the sample application station is located on the peripheral side of the reaction mechanism 150. This can shorten the transfer path of the reaction vessel. Of course, in other embodiments of the present invention, the sample application station may be disposed at other positions of the test bed as long as it is ensured that the sample application station is located in the movement track of the sample needle 121 and the movement range of the transfer mechanism.

In one embodiment, after the controller 50 controls the sample needle 121 to discharge the third predetermined amount of the sample to be measured, the controller 50 further controls the cleaning mechanism to clean the inner wall and the outer wall of the sample needle 121 at the cleaning station. That is, after the controller 50 controls the sample needle 121 to add the sample to be measured to the reaction container, the controller 50 can control the sample needle 121 to move to the cleaning station through the driving assembly 122, and control the cleaning mechanism to clean the inner wall and the outer wall of the sample needle 121.

After the cleaning mechanism cleans the inner wall and the outer wall of the sample needle 121, the sample to be measured attached to the sample needle 121 can be effectively removed, and the tidiness of the sample needle 121 is ensured. Thus, the controller 50 can control the sample needle 121 for cleaning the outer wall and the inner wall to perform the transfer operation of the next sample to be measured. Through the cleaning of the cleaning mechanism, the cross infection among samples to be detected can be avoided, and the accuracy of the sample detection result is ensured.

Referring to fig. 2, 3 and 7, in an embodiment, the cleaning mechanism includes a first cleaning tank 170, a second cleaning tank 170, and a cleaning pipeline 173, the first cleaning tank 170 and the second cleaning tank are used for cleaning the outer wall of the sample needle 121, the cleaning pipeline 173 communicates with the sample needle 121, and the cleaning liquid flows into the sample needle 121 through the cleaning pipeline 173. After the controller 50 controls the sample needle 121 to discharge the second preset amount of the sample to be measured, the controller 50 controls the first cleaning cell 170 to clean the outer wall of the sample needle 121. After the controller 50 controls the sample needle 121 to discharge a third predetermined amount of the sample to be measured, the controller 50 controls the second cleaning tank to clean the outer wall of the sample needle 121 and controls the cleaning pipeline 173 to clean the inner wall of the sample needle 121.

That is, the cleaning mechanism cleans the sample needle 121 after the sample suction and the sample needle 121 after the sample addition by different members. The first cleaning tank 170 and the second cleaning tank are independently provided, and the first cleaning tank 170 and the second cleaning tank can clean the outer wall of the sample needle 121. Specifically, the first cleaning tank 170 and the second cleaning tank can spray cleaning liquid, so that the cleaning liquid cleans the outer wall of the sample needle 121, and waste liquid after cleaning is discharged from the first cleaning tank 170 and the second cleaning tank.

Also, a cleaning line 173 is connected to the end of the sample needle 121, and one end of the cleaning line 173 communicates with the interior of the sample needle 121, so that the cleaning line 173 communicates with the cleaning liquid storage container. A first on-off valve 174 is provided in the cleaning line 173, and the on-off of the cleaning line 173 is controlled by the first on-off valve 174. When the first switching valve 174 opens the cleaning line 173, the cleaning liquid in the cleaning liquid storage container enters the sample needle 121 through the cleaning line 173, and cleaning of the inside of the sample needle 121 is achieved. When the first switching valve 174 closes the cleaning line 173, the cleaning liquid in the cleaning liquid storage container does not enter the sample needle 121. After the cleaning of the sample needle 121 is completed, the waste liquid inside the sample needle 121 is discharged into the second cleaning tank, and is discharged through the second cleaning tank.

The first cleaning tank 170 and the second cleaning tank are both disposed on the movement locus of the sample needle 121. During cleaning, the controller 50 can determine whether the sample needle 121 moves to the first cleaning tank 170 to clean the outer wall or to the second cleaning tank to clean the inner wall and the outer wall in cooperation with the cleaning pipeline 173 according to the previous station of the sample needle 121.

Specifically, when the controller 50 controls the sample needle 121 to discharge the second preset amount of the sample to be measured, which indicates that the sample needle 121 has just finished aspirating, it is necessary to clean the outer wall of the sample needle 121 to remove the interfering substance adhered to the outer wall of the sample needle 121. At this time, the controller 50 controls the sample needle 121 to move to the first washing pool 170, and controls the sample needle 121 to extend into the first washing pool 170, and then, the controller 50 controls the first washing pool 170 to eject the washing liquid to wash the outer wall of the sample needle 121.

When the controller 50 controls the sample needle 121 to discharge a third predetermined amount of sample to be tested, it indicates that the sample needle 121 has just completed the sample loading operation, the sample needle 121 completes one cycle of sample transferring operation, and the next sample to be tested needs to be dedicated, so the outer wall and the inner wall of the sample needle 121 need to be cleaned to remove the sample to be tested on the inner wall and the outer wall of the sample needle 121, thereby avoiding cross contamination. At this time, the controller 50 controls the sample needle 121 to move to the second washing tank, and controls the sample needle 121 to extend into the second washing tank. Subsequently, the controller 50 controls the second cleaning tank to eject the cleaning liquid to clean the outer wall of the sample needle 121; and, the controller 50 controls the first switching valve 174 to be opened, so that the cleaning liquid enters the inside of the sample needle 121 through the cleaning line 173, and cleans the inner wall of the sample needle 121.

Referring to fig. 2 to 4, in an embodiment, the cleaning mechanism includes a first cleaning tank 170 and a cleaning pipeline 173, the first cleaning tank 170 is used for cleaning the outer wall of the sample needle 121, the cleaning pipeline 173 is communicated with the sample needle 121, and the cleaning liquid flows into the sample needle 121 through the cleaning pipeline 173. After the controller 50 controls the sample needle 121 to discharge the second preset amount of the sample to be measured, the controller 50 controls the first cleaning cell 170 to clean the outer wall of the sample needle 121. After the controller 50 controls the sample needle 121 to discharge a third predetermined amount of the sample to be measured, the controller 50 controls the first cleaning tank 170 to clean the outer wall of the sample needle 121 and controls the cleaning pipeline 173 to clean the inner wall of the sample needle 121.

That is, the cleaning mechanism cleans the sample needle 121 after the sample suction and the sample needle 121 after the sample addition by the same member. Therefore, the size of the cleaning mechanism can be reduced, the occupied space is further reduced, and the whole part of the sample analyzer A is convenient. The first washing tank 170 can wash the outer wall of the sample needle 121. Specifically, the first cleaning tank 170 can eject a cleaning liquid, so that the cleaning liquid cleans the outer wall of the sample needle 121, and the waste liquid after cleaning is discharged from the first cleaning tank 170.

Also, a cleaning line 173 is connected to the end of the sample needle 121, and one end of the cleaning line 173 communicates with the interior of the sample needle 121, communicating the cleaning line 173 to the cleaning liquid storage container. A first on-off valve 174 is provided in the cleaning line 173, and the on-off of the cleaning line 173 is controlled by the first on-off valve 174. When the first switching valve 174 opens the cleaning line 173, the cleaning liquid in the cleaning liquid storage container enters the sample needle 121 through the cleaning line 173, and cleaning of the inside of the sample needle 121 is achieved. When the first switching valve 174 closes the cleaning line 173, the cleaning liquid in the cleaning liquid storage container does not enter the sample needle 121. After the cleaning of the sample needle 121 is completed, the waste liquid inside the sample needle 121 is discharged into the first cleaning tank 170, and is discharged through the first cleaning tank 170.

The first washing tank 170 is disposed on the movement locus of the sample needle 121. During the cleaning, the controller 50 can determine whether the sample needle 121 is to clean the outer wall of the sample needle 121 through the first cleaning tank 170 or to clean the inner wall and the outer wall of the sample needle 121 through the first cleaning tank 170 and the cleaning pipeline 173 in cooperation with each other according to the previous station of the sample needle 121.

When the controller 50 controls the sample needle 121 to discharge a third predetermined amount of sample to be tested, it indicates that the sample needle 121 has just completed the sample loading operation, the sample needle 121 completes one cycle of sample transferring operation, and the next sample to be tested needs to be dedicated, so the outer wall and the inner wall of the sample needle 121 need to be cleaned to remove the sample to be tested on the inner wall and the outer wall of the sample needle 121, thereby avoiding cross contamination. At this time, the controller 50 controls the sample needle 121 to move to the first washing tank 170, and controls the sample needle 121 to extend into the first washing tank 170. Subsequently, the controller 50 controls the first cleaning tank 170 to eject the cleaning liquid to clean the outer wall of the sample needle 121; and, the controller 50 controls the first switching valve 174 to be opened, so that the cleaning liquid enters the inside of the sample needle 121 through the cleaning line 173, and cleans the inner wall of the sample needle 121.

Referring to fig. 3 and 4, in an embodiment, the first cleaning cell 170 has a first cleaning position and a second cleaning position, the controller 50 controls the sample needle 121 discharging the second predetermined amount of the sample to be measured to clean the outer wall at the first cleaning position, and the controller 50 controls the sample needle 121 discharging the third predetermined amount of the sample to be measured to clean the outer wall and the inner wall at the second cleaning position, where the first cleaning position is higher than the second cleaning position.

That is, when the sample needles 121 in different states are cleaned using the same component, the controller 50 controls the sample needles 121 to be in different cleaning positions, to perform cleaning of the outer wall, or to perform cleaning of the inner and outer walls. The first cleaning tank 170 has a first cleaning position where the outer wall of the sample needle 121 is cleaned, and a second cleaning position where the inner wall and the outer wall of the sample needle 121 are cleaned.

Specifically, after the controller 50 controls the sample needle 121 to discharge the second preset amount of the sample to be measured, the controller 50 controls the sample needle 121 to move to the first cleaning position in the first cleaning pool 170, and controls the first cleaning pool 170 to spray the cleaning liquid to clean the outer wall of the sample needle 121. The sample needle 121 extends into the first cleaning position as shown in fig. 3, and after the sample needle 121 is at the first cleaning position, the height between the tip of the sample needle 121 and the bottom of the first cleaning tank 170 is h.

After the controller 50 controls the sample needle 121 to discharge a third predetermined amount of the sample to be measured, the controller 50 controls the sample needle 121 to move to the second cleaning position in the first cleaning tank 170, controls the first cleaning tank 170 to eject the cleaning liquid to clean the outer wall of the sample needle 121, and controls the cleaning pipeline 173 to clean the inner wall of the sample needle 121. The sample needle 121 extends into the second cleaning position as shown in fig. 4, and after the sample needle 121 is in the second cleaning position, the height between the tip of the sample needle 121 and the bottom of the first cleaning pool 170 is H.

Also, the first cleaning position is higher than the second cleaning position. That is, the controller 50 controls the descending height of the sample needle 121 discharging the second preset amount of the sample to be measured to be smaller than the descending height of the sample needle 121 discharging the third preset amount of the sample to be measured by the controller 50. Therefore, after the sample needle 121 moves to the second position, the cleaning mechanism can be guaranteed to comprehensively clean the sample needle 121, the cleaning is guaranteed, and cross contamination is avoided.

Referring to fig. 5, in an embodiment, the first cleaning tank 170 includes a cleaning tank body 171, a nozzle 172, a vacuum pump and a liquid storage tank, the cleaning tank body 171 has a cleaning cavity and a cleaning hole communicated with the cleaning cavity, the nozzle 172 is disposed in the cleaning hole and is used for injecting a cleaning liquid into the cleaning cavity, and the vacuum pump is used for sucking the cleaned cleaning liquid into the liquid storage tank.

The nozzle 172 is connected to the cleaning solution storage container, and a second on-off valve 175 is also provided in a connection line of the nozzle 172. After the sample needle 121 extends into the cleaning tank body 171, the controller 50 controls the second on-off valve 175 to open, and the cleaning liquid can be sprayed out through the nozzle 172 to spray the cleaning liquid on the outer wall of the sample needle 121, so as to clean the outer wall of the sample needle 121. Optionally, the number of the nozzles 172 is plural, and the plural nozzles 172 are arranged at intervals along the circumference of the cleaning chamber.

Moreover, the bottom of the cleaning cavity is also provided with a vacuum pump which can suck the waste liquid in the cleaning tank body 171 and store the waste liquid in the liquid storage tank to be discharged. Through the suction effect of vacuum pump, can effectually get rid of the waste liquid after wasing in the washing cavity, can also weather the washing liquid of sample needle 121 outer wall simultaneously, avoid the sample liquid of sample needle 121 outer wall to remain, guarantee the accuracy of the sample testing result that awaits measuring.

It can be understood that the structure of the second cleaning tank is identical to the structure of the first cleaning tank 170, and the detailed description is omitted here.

Referring to fig. 2 and 7, in one embodiment, the sample analyzer a further includes a liquid discharge station provided with a liquid discharge container to which the sample needle 121 discharges a second preset amount of the sample to be measured. That is, the liquid discharge station is provided separately from the cleaning station, and the liquid discharge station is located on the movement locus of the sample needle 121. After the controller 50 controls the sample needle 121 to suck the first preset amount of sample to be measured, the controller 50 can control the sample needle 121 to move to the liquid discharge station. Subsequently, the controller 50 can control the sample needle 121 to discharge a second preset amount of the sample to be measured into the drainage container of the drainage station. After the liquid discharge is completed, the controller 50 controls the sample needle 121 to move to the cleaning station, and the outer wall of the sample needle 121 is cleaned by the first cleaning tank 170.

Alternatively, the drain container is a reaction cup or a waste liquid tank or the like capable of storing waste liquid. Alternatively, the drainage container may be replaced with a single use, or may be replaced with multiple uses.

Of course, in other embodiments of the invention, the sample needle 121 discharges a second preset amount of the sample to be measured into the cleaning mechanism at the cleaning station. That is, the sample needle 121 discharges the second preset amount of the sample to be measured directly at the cleaning station. After the controller 50 controls the sample needle 121 to suck the first preset amount of sample to be measured, the controller 50 can control the sample needle 121 to move to the cleaning station, and control the sample needle 121 to extend into the first cleaning position of the first cleaning pool 170. Subsequently, the controller 50 can control the sample needle 121 to discharge a second preset amount of the sample to be measured into the first washing tank 170. After the liquid discharge is completed, the controller 50 controls the first cleaning tank 170 to clean the outer wall of the sample needle 121.

Referring to fig. 2 and 7, in an embodiment, the controller 50 controls the sample needle 121 to suck a first preset volume of air after sucking a first preset amount of sample to be measured at the sample sucking station. After the sample needle 121 discharges the second preset amount of the sample to be measured, the controller 50 further controls the sample needle 121 to suck a second preset volume of air. After the sample needle 121 discharges a third preset amount of the sample to be measured, the controller 50 further controls the sample needle 121 to suck a third preset volume of air.

The controller 50 controls the sample needle 121 to suck a first preset amount of sample to be measured, and then sucks a first preset volume of air. After the controller 50 controls the sample needle 121 to move to the sample sucking station through the driving component 122, the controller can also drive the sample needle 121 to descend so as to extend into the sample tube to suck a first preset amount of sample to be detected. After the sample sucking of the sample needle 121 is completed, the controller 50 controls the sample needle 121 to ascend, and then, the controller 50 controls the sample needle 121 to suck the first preset volume of air. The controller 50 then controls the sample needle 121 to switch stations via the driving assembly 122.

After the sample needle 121 sucks the first preset volume of air, a certain distance can exist between the sample to be measured in the sample needle 121 and the needle tip of the sample needle 121. Like this, when controller 50 control sample needle 121 moved, the sample that awaits measuring in the sample needle 121 can not thrown away, guarantees the reliability of the sample transfer process that awaits measuring, avoids appearing the weeping problem, guarantees the neatness in the testing process, avoids appearing the sample pollution.

The controller 50 controls the sample needle 121 to discharge a second predetermined amount of the sample to be measured, and then sucks a second predetermined volume of air. The controller 50 controls the movement of the sample needle 121 through the driving assembly 122, and also can drive the sample needle 121 to descend and control the sample needle 121 to discharge a second preset amount of sample to be measured. After the liquid discharge of the sample needle 121 is completed, the controller 50 controls the sample needle 121 to ascend, and then, the controller 50 controls the sample needle 121 to suck a second preset volume of air. The controller 50 then controls the sample needle 121 to switch stations via the driving assembly 122.

After the sample needle 121 sucks the second preset volume of air, a certain distance can exist between the sample to be measured in the sample needle 121 and the needle tip of the sample needle 121. Like this, when controller 50 control sample needle 121 moved, the sample that awaits measuring in the sample needle 121 can not thrown away, guarantees the reliability of the sample transfer process that awaits measuring, avoids appearing the weeping problem, guarantees the neatness in the testing process, avoids appearing the sample pollution.

The controller 50 controls the sample needle 121 to discharge a third preset amount of the sample to be measured, and then sucks a third preset volume of air. After the controller 50 controls the sample needle 121 to move to the sample application station through the driving assembly 122, the controller can also drive the sample needle 121 to descend, and control the sample needle 121 to discharge a third preset amount of sample to be tested to the reaction container. After the sample needle 121 is completely loaded, the controller 50 controls the sample needle 121 to ascend, and then the controller 50 controls the sample needle 121 to suck a third preset volume of air, and controls the sample needle 121 to load the sample to be tested into the reaction container again. After the sample application is completed, the controller 50 controls the sample needle 121 to ascend.

After the sample needle 121 sucks the third preset volume of air, the sample to be measured in the sample needle 121 can be sufficiently mixed with the air. Thus, when the controller 50 controls the sample needle 121 to add the sample to be detected into the reaction container again, the sample to be detected attached to the inner wall of the sample needle 121 can be completely discharged, the sample to be detected remaining in the sample needle 121 is avoided, the loss of the sample to be detected is reduced, and the sufficient sample to be detected is ensured to be detected; meanwhile, the later cleaning of the sample needle 121 can be facilitated.

Referring to fig. 7, in the sample analyzer a of the present invention, when in use, the controller 50 controls the sample needle 121 to move to the sample sucking station, and then controls the sample needle 121 to suck the sample to be measured in the sample tube, as shown in fig. 7 (a). Subsequently, the controller 50 controls the sample needle 121 to move to the first washing pool 170, and then controls the sample needle 121 to extend into the first washing position of the first washing pool 170. After the sample needle 121 is moved to the proper position, the controller 50 controls the sample needle 121 to discharge a second preset amount of the sample to be measured, as shown in (b) of fig. 7. After the controller 50 controls the sample needle 121 to discharge the second preset amount of the sample to be measured, the controller 50 controls the first cleaning cell 170 to clean the sample needle 121, as shown in (c) of fig. 7.

The controller 50 controls the sample needle 121 after cleaning the outer wall to move to the sample application station, and controls the sample needle 121 to apply a third preset amount of the sample to be measured to the reaction container, as shown in fig. 7 (d). After the controller 50 controls the sample needle 121 to complete the sample loading operation at the sample loading station, the controller 50 controls the sample needle 121 to move to the first cleaning pool 170, controls the sample needle 121 to extend into the second cleaning position of the first cleaning pool 170, and controls the first cleaning pool 170 and the cleaning pipeline 173 to clean the outer wall and the inner wall of the sample needle 121, as shown in fig. 7 (e).

Referring to fig. 2, in an embodiment, the sample analyzer a further includes a scanning component electrically connected to the controller 50, the scanning component is configured to scan an identification code corresponding to a sample to be tested, and the controller 50 is configured to obtain a testing item of the sample to be tested according to a scanning result of the scanning component and control a sample application operation of the sample needle according to the testing item of the sample to be tested. The sample application operation of the sample needle 121 includes: the sample needle 121 sucks a first preset amount of samples to be detected at a sample sucking station; the sample needle 121 discharges a second preset amount of the sample to be measured; the cleaning mechanism cleans the outer wall of the sample needle 121 at a cleaning station; moving the cleaned sample needle 121 to a sample adding station, and adding a third preset amount of sample to be detected into the reaction container; alternatively, the sample adding operation of the sample needle 121 includes: the sample needle 121 sucks a sample to be tested at the sample sucking station, then directly moves to the sample adding station, and injects the sample to be tested into the reaction container.

The sample tube carrying the sample to be tested is typically tagged with an identification code in which information relating to the patient can be stored. The sample analyzer A is in communication connection with a hospital system, and corresponding detection item information can be stored in the hospital system corresponding to patient information. The controller 50 can determine whether the sample needle 121 after the sample aspiration needs to clean the outer wall based on the detection item information.

The scanning component can scan the identification code on the sample tube to obtain the patient information represented by the identification code. The controller 50 can receive the patient information fed back by the scanning unit and acquire the corresponding detection item information according to the patient information.

It can be understood that the medical system is provided with a project library, and preset projects are stored in the project library in advance. The judgment standard of the preset item refers to the sensitivity of the interference substance on the influence of the sample to be detected in the detection. And (3) the interference substances are sensitive to the influence of the sample to be detected, namely the interference substances have larger influence on the detection result of the sample to be detected, and the item is a preset item and is included in the item library. And the interference substances are insensitive to the influence of the sample to be detected, namely the interference substances have small detection influence on the sample to be detected, and the item is not included in the item library.

After acquiring the test item information according to the patient information, the controller 50 compares the test items of the patient with preset items in the item library. If the detection item is matched with the preset item in the item library, it is indicated that the interference substance has a relatively large influence on the detection result of the sample to be detected. Therefore, after the controller 50 controls the sample needle 121 to completely suck the sample, the controller 50 also needs to control the cleaning mechanism to clean the outer wall of the sample needle 121, so as to reduce the influence of the interfering object on the accuracy of the detection result of the sample to be detected.

And if the detection item is not matched with the preset item in the item library, indicating that the influence of the interference substance on the detection result of the sample to be detected is small. Therefore, after the controller 50 controls the sample needle 121 to suck the sample, the controller can directly control the sample needle 121 to move to the sample adding station to perform the sample adding operation, and the outer wall of the sample needle 121 does not need to be cleaned. Therefore, the detection time of the sample to be detected can be shortened, and the detection efficiency is improved.

That is to say, through the cooperation of the identification code of scanning component and sample pipe, transfer the patient information of the sample that awaits measuring, controller 50 can transfer corresponding detection item information according to patient information, and then judges that the sample needle 121 after the absorption of sample directly moves to the application of sample station or need move to the washing station to guarantee the accuracy of the sample testing result that awaits measuring. In some embodiments, the patient information and the test item information corresponding to the sample may be manually input by a human or locally imported through a storage medium such as a USB.

Referring to fig. 2 and 8, the present invention also provides a sample analysis method applied to the sample analyzer a in any one of the above embodiments, the sample analysis method including the steps of:

the sample needle 121 sucks a first preset amount of samples to be detected at a sample sucking station;

the sample needle 121 discharges a second preset amount of the sample to be measured;

the cleaning mechanism cleans the outer wall of the sample needle 121 at a cleaning station;

moving the cleaned sample needle 121 to a sample adding station, and adding a third preset amount of sample to be detected into the reaction container;

and measuring the sample to be measured in the reaction container.

The sample analysis method of the present embodiment is based on the sample analyzer a of the above-described embodiment. When the sample analyzer a operates according to the sample analysis method, the controller 50 drives the sample needle 121 to move to the sample suction station through the driving assembly 122, and then controls the sample needle 121 to extend into the sample container at the sample suction station to suck a first preset amount of sample to be measured. After the sample suction of the sample needle 121 is completed, the controller 50 controls the sample needle 121 to move upward to move out of the sample tube. Subsequently, the controller 50 controls the sample needle 121 to discharge a second preset amount of the sample to be measured to discharge the sample to be measured containing the interfering substance at the needle tip position of the sample needle 121.

Then, the controller 50 controls the sample needle 121 at the cleaning station, and controls the cleaning mechanism to clean the outer wall of the sample needle 121 to remove the interfering substances on the outer wall of the sample needle 121. After the cleaning of the outer wall of the sample needle 121 is completed, the controller 50 controls the sample needle 121 to move to the sample application station through the driving assembly 122, and controls the sample needle 121 to inject a third preset amount of the sample to be measured into the reaction container. Thus, the sample adding operation is completed, and then, the sample to be detected can be detected.

In one embodiment, the step of determining the sample to be tested in the reaction container comprises the following steps:

adding a reagent to the reaction vessel;

controlling the reaction mechanism 150 to incubate a reaction solution formed by a sample to be tested and a reagent in the reaction container;

the sample measuring means 160 is controlled to detect the incubated reaction solution.

After the controller 50 controls the sample needle 121 to add a third preset amount of the sample to be detected to the reaction vessel, the controller 50 controls the reagent dispensing mechanism 140 to add the reagent to the reaction vessel, incubates the reaction solution in the reaction cup through the reaction mechanism 150, transfers the incubated reaction vessel to the sample measuring mechanism 160, and detects the incubated reaction solution through the sample measuring mechanism 160 to obtain the detection result of the sample to be detected.

In an embodiment, after the step of moving the cleaned sample needle 121 to the sample adding station and adding the third preset amount of the sample to be tested to the reaction container, the sample analyzing method further includes the following steps:

the cleaning mechanism cleans the outer wall and the inner wall of the sample needle 121 at the cleaning station.

That is, after the controller 50 controls the sample needle 121 to add the sample to be measured to the reaction container, the controller 50 can control the sample needle 121 to move to the cleaning station through the driving assembly 122, and control the cleaning mechanism to clean the inner wall and the outer wall of the sample needle 121.

After the cleaning mechanism cleans the inner wall and the outer wall of the sample needle 121, the sample to be measured attached to the sample needle 121 can be effectively removed, and the tidiness of the sample needle 121 is ensured. In this way, the controller 50 can control the sample needle 121 cleaning the outer wall and the inner wall to perform the transfer operation of the next sample to be measured. Through the cleaning of the cleaning mechanism, the cross infection among samples to be detected can be avoided, and the accuracy of the sample detection result is ensured.

In one embodiment, the sample analysis method further comprises the steps of:

after the sample needle 121 discharges the second preset amount of the sample to be measured, the cleaning mechanism cleans the outer wall of the sample needle 121 at the first cleaning position;

after the sample needle 121 discharges the third preset amount of sample to be measured, the cleaning mechanism cleans the outer wall and the inner wall of the sample needle 121 at the second cleaning position;

the first cleaning position is higher than the second cleaning position.

The sample analyzer a can clean the sample needle 121 by the same cleaning member. When the same component is used for cleaning the sample needle 121 in different states, the controller 50 controls the sample needle 121 to be in different cleaning positions, so as to clean the outer wall, or clean the inner wall and the outer wall. The first cleaning tank 170 has a first cleaning position where the outer wall of the sample needle 121 is cleaned, and a second cleaning position where the inner wall and the outer wall of the sample needle 121 are cleaned.

In one embodiment, the cleaning mechanism comprises a first cleaning cell 170 and a cleaning pipeline 173, the first cleaning cell 170 is used for cleaning the outer wall of the sample needle 121, the cleaning pipeline 173 is communicated with the sample needle 121, and the cleaning liquid flows into the sample needle 121 through the cleaning pipeline 173; the sample analysis method comprises the following steps:

after the second preset amount of the sample to be measured is discharged from the sample needle 121, the first cleaning tank 170 cleans the outer wall of the sample needle 121;

after the third preset amount of the sample to be measured is discharged from the sample needle 121, the first cleaning tank 170 cleans the outer wall of the sample needle 121, and the cleaning pipeline 173 cleans the inner wall of the sample needle 121.

Specifically, after the controller 50 controls the sample needle 121 to discharge the second preset amount of the sample to be measured, the controller 50 controls the sample needle 121 to move to the first cleaning position in the first cleaning tank 170, and controls the first cleaning tank 170 to spray the cleaning solution to clean the outer wall of the sample needle 121. After the controller 50 controls the sample needle 121 to discharge a third predetermined amount of the sample to be measured, the controller 50 controls the sample needle 121 to move to the second cleaning position in the first cleaning tank 170, controls the first cleaning tank 170 to eject the cleaning liquid to clean the outer wall of the sample needle 121, and controls the cleaning pipeline 173 to clean the inner wall of the sample needle 121.

In an embodiment, the discharging of the second preset amount of the sample to be measured by the sample needle 121 specifically includes the following steps:

the sample needle 121 moves to a liquid discharge station, and discharges the second preset amount of sample to be measured into a liquid discharge container of the liquid discharge station;

alternatively, the sample needle 121 discharges the second preset amount of the sample to be measured into the cleaning mechanism at the cleaning station.

Alternatively, a liquid discharge station is provided separately from the cleaning station, the liquid discharge station being located on the movement locus of the sample needle 121. After the controller 50 controls the sample needle 121 to suck the first preset amount of sample to be measured, the controller 50 can control the sample needle 121 to move to the liquid discharge station. Subsequently, the controller 50 can control the sample needle 121 to discharge a second preset amount of the sample to be measured into the drainage container of the drainage station. After the liquid discharge is completed, the controller 50 controls the sample needle 121 to move to the cleaning station, and the outer wall of the sample needle 121 is cleaned by the first cleaning tank 170.

Alternatively, the drain container is a reaction cup or a waste liquid tank or the like capable of storing waste liquid. Alternatively, the drainage container may be replaced with one use, or may be replaced with multiple uses.

Of course, in other embodiments of the present invention, the sample needle 121 discharges the second preset amount of the sample to be measured directly at the cleaning station. After the controller 50 controls the sample needle 121 to suck the first preset amount of sample to be measured, the controller 50 can control the sample needle 121 to move to the cleaning station, and control the sample needle 121 to extend into the first cleaning position of the first cleaning pool 170. Subsequently, the controller 50 can control the sample needle 121 to discharge a second preset amount of the sample to be measured into the first washing tank 170. After the liquid discharge is completed, the controller 50 controls the first cleaning tank 170 to clean the outer wall of the sample needle 121.

In one embodiment, the sample analysis method further comprises the steps of:

after the sample needle 121 sucks the first preset amount of sample to be detected at the sample sucking station, sucking a first preset volume of air;

after the sample needle 121 discharges the second preset amount of the sample to be measured, sucking air with a second preset volume;

after the third preset amount of the sample to be measured is added into the reaction container by the sample needle 121, a third preset volume of air is sucked.

The controller 50 controls the sample needle 121 to suck a first preset amount of sample to be measured, and then sucks a first preset volume of air. After the controller 50 controls the sample needle 121 to move to the sample sucking station through the driving component 122, the controller can also drive the sample needle 121 to descend so as to extend into the sample tube to suck a first preset amount of sample to be detected. After the sample sucking of the sample needle 121 is completed, the controller 50 controls the sample needle 121 to ascend, and then, the controller 50 controls the sample needle 121 to suck the first preset volume of air. The controller 50 then controls the sample needle 121 to switch the stations via the driving assembly 122.

The invention also provides a sample analysis method, which comprises the following steps:

obtaining detection items of a sample to be detected;

determining the sample adding operation of the sample needle 121 according to the detection items of the sample to be detected;

measuring a sample to be measured;

when the detection item of the sample to be detected satisfies the preset condition, the sample adding operation of the sample needle 121 includes: the sample needle 121 sucks a first preset amount of samples to be detected at a sample sucking station; the sample needle 121 discharges a second preset amount of the sample to be measured; the cleaning mechanism cleans the outer wall of the sample needle 121 at a cleaning station; moving the cleaned sample needle 121 to a sample adding station, and adding a third preset amount of sample to be detected into the reaction container;

when the detection item of the sample to be detected does not satisfy the preset condition, the sample adding operation of the sample needle 121 includes: the sample needle 121 sucks a sample to be tested at the sample sucking station, then directly moves to the sample adding station, and injects the sample to be tested into the reaction container.

The sample tube bearing the sample to be detected is pasted with an identification code, and the relevant information of the patient can be stored in the identification code. The sample analyzer A is in communication connection with a hospital system, and corresponding detection item information can be stored in the hospital system corresponding to patient information. The controller 50 can determine whether the sample needle 121 after the sample aspiration needs to clean the outer wall based on the detection item information.

The scanning component is arranged on the test bed and is arranged corresponding to the sample adding station. The scanning component can scan the identification code on the sample tube to obtain the patient information represented by the identification code. The controller 50 can receive the patient information fed back by the scanning component and detect the item information according to the patient information. Moreover, after the scanning component scans the sample tube, the sample conveying mechanism 110 conveys the sample tube to a sample suction station for the sample needle 121 to suck a sample, so as to ensure that the patient information can correspond to the sample to be measured one by one.

It can be understood that a project library with preset conditions is provided in the medical system, and preset projects are stored in the project library in advance. The judgment standard of the preset item refers to the sensitivity of the interference substance on the influence of the sample to be detected in the detection. And (3) the interference substances are sensitive to the influence of the sample to be detected, namely the interference substances have larger influence on the detection result of the sample to be detected, and the item is a preset item and is included in the item library. And the interference substances are insensitive to the influence of the sample to be detected, namely the interference substances have small detection influence on the sample to be detected, and the item is not included in the item library.

The controller 50 compares the examination items of the patient with preset items in an item library after acquiring examination item information based on the patient information. If the detection items are matched with the preset items in the item library, namely the detection items of the sample to be detected meet the preset conditions, it is indicated that the influence of the interference substances on the detection result of the sample to be detected is large. Therefore, after the controller 50 controls the sample needle 121 to suck the first predetermined amount of the sample to be tested at the first position, the controller 50 controls the sample needle 121 to discharge the second predetermined amount of the sample to be tested, and then controls the cleaning mechanism to clean the outer wall of the sample needle 121, so as to reduce the influence of the interfering object on the accuracy of the test result of the sample to be tested. Then, the controller 50 controls the sample needle 121 with the outer wall cleaned to move to the sample application station, so as to add a third preset amount of the sample to be tested into the reaction container.

If the detection item is not matched with the preset item in the item library, that is, the detection item of the sample to be detected does not meet the preset condition, it is indicated that the influence of the interfering substance on the detection result of the sample to be detected is small, and the interfering substance carried by the sample needle 121 does not need to be removed. Therefore, after the controller 50 controls the sample needle 121 to suck the sample, the controller can directly control the sample needle 121 to move to the sample adding station to perform the sample adding operation, and the outer wall of the sample needle 121 does not need to be cleaned. Therefore, the detection time of the sample to be detected can be shortened, and the detection efficiency is improved.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. A sample analyzer is characterized by comprising a sample sucking station, a cleaning station and a sample adding station, and further comprising a controller, a sample injecting mechanism and a cleaning mechanism, wherein the sample injecting mechanism is electrically connected with the controller, the sample injecting mechanism comprises a sample needle and a driving component in transmission connection with the sample needle, and the controller controls the driving component to drive the sample needle to move among the sample sucking station, the cleaning station and the sample adding station;

the controller controls the sample needle to suck a first preset amount of samples to be detected at the sample sucking station, controls the cleaning mechanism to clean the outer wall of the sample needle at the cleaning station after controlling the sample needle to discharge a second preset amount of samples to be detected, and controls the cleaned sample needle to inject a third preset amount of samples to be detected into a reaction container at the sample adding station, wherein the second preset amount is smaller than the first preset amount, and the third preset amount is smaller than or equal to the difference between the first preset amount and the second preset amount.

2. The sample analyzer of claim 1, wherein after the controller controls the sample needle to discharge the third predetermined amount of sample to be tested, the controller further controls the cleaning mechanism to clean the inner and outer walls of the sample needle at the cleaning station.

3. The sample analyzer of claim 2, wherein the cleaning mechanism comprises a first cleaning cell, a second cleaning cell, and a cleaning conduit, the first cleaning cell and the second cleaning cell are used for cleaning the outer wall of the sample needle, the cleaning conduit communicates with the sample needle, and a cleaning liquid flows into the sample needle through the cleaning conduit;

after the controller controls the sample needle to discharge the third preset amount of sample to be measured, the controller controls the second cleaning pool to clean the outer wall of the sample needle and controls the cleaning pipeline to clean the inner wall of the sample needle.

4. The sample analyzer of claim 2, wherein the cleaning mechanism comprises a first cleaning cell for cleaning an outer wall of the sample needle and a cleaning conduit communicating with the sample needle, wherein a cleaning solution flows into the sample needle through the cleaning conduit;

5. The sample analyzer as claimed in claim 4, wherein the first washing tank has a first washing position and a second washing position, the controller controls the sample needle discharging the second preset amount of the sample to be measured to wash the outer wall at the first washing position, the controller controls the sample needle discharging the third preset amount of the sample to be measured to wash the outer wall and the inner wall at the second washing position, and the first washing position is higher than the second washing position.

6. The sample analyzer of claim 1, further comprising a liquid discharge station provided with a liquid discharge container to which the sample needle discharges the second preset amount of sample to be tested;

7. The sample analyzer as claimed in claim 1, wherein the controller controls the sample needle to draw a first preset volume of air after a first preset amount of sample to be measured is drawn by the sample needle at the sample drawing station;

8. The sample analyzer as claimed in claim 1, wherein the controller is further configured to obtain a test item of a sample to be tested, and to control the loading operation of the sample needle according to the test item of the sample to be tested, the loading operation of the sample needle comprising: the sample needle sucks a first preset amount of samples to be detected at the sample sucking station; the sample needle discharges a second preset amount of samples to be detected; the cleaning mechanism cleans the outer wall of the sample needle at the cleaning station; moving the cleaned sample needle to the sample adding station, and adding a third preset amount of sample to be detected into the reaction container;

or, the sample loading operation of the sample needle comprises: and the sample needle directly moves to the sample adding station after sucking the sample to be detected at the sample sucking station, and injects the sample to be detected into the reaction container.

9. The sample analyzer as claimed in claim 1, further comprising a sample transport mechanism for transporting the sample to be measured, a reagent dispensing mechanism for transferring a reagent, a reaction mechanism for incubating a reaction solution formed by mixing the sample to be measured with the reagent, a reagent storage mechanism for storing the reagent, a transfer mechanism for transferring the reaction vessel, and a sample measurement mechanism for measuring the sample to be measured.

10. A sample analysis method applied to a sample analyzer, the sample analysis method comprising the steps of:

the sample needle discharges a second preset amount of samples to be detected;

and measuring the sample to be measured in the reaction container.

11. The sample analysis method according to claim 10, wherein after the step of moving the cleaned sample needle to the loading station to add a third preset amount of the sample to be tested to the reaction vessel, the sample analysis method further comprises the steps of:

12. The sample analysis method of claim 11, further comprising the steps of:

the first cleaning position is higher than the second cleaning position.

13. The method for analyzing a sample according to claim 10, wherein the sample needle discharges a second predetermined amount of the sample to be tested, comprising the following steps:

14. The sample analysis method of claim 10, further comprising the steps of:

15. A method of analyzing a sample, comprising the steps of:

obtaining detection items of a sample to be detected;

measuring a sample to be measured;