CN114699073A - Three-way pipeline and monitoring system for monitoring concentration of substances in blood - Google Patents
Three-way pipeline and monitoring system for monitoring concentration of substances in blood Download PDFInfo
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- CN114699073A CN114699073A CN202210377035.1A CN202210377035A CN114699073A CN 114699073 A CN114699073 A CN 114699073A CN 202210377035 A CN202210377035 A CN 202210377035A CN 114699073 A CN114699073 A CN 114699073A
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- 239000008280 blood Substances 0.000 title claims abstract description 49
- 210000004369 blood Anatomy 0.000 title claims abstract description 49
- 239000000126 substance Substances 0.000 title claims abstract description 36
- 238000012544 monitoring process Methods 0.000 title claims abstract description 26
- 238000001514 detection method Methods 0.000 claims abstract description 50
- 210000001124 body fluid Anatomy 0.000 claims abstract description 37
- 239000010839 body fluid Substances 0.000 claims abstract description 37
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 34
- 239000000523 sample Substances 0.000 claims abstract description 28
- 238000001228 spectrum Methods 0.000 claims abstract description 8
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims description 16
- 239000002699 waste material Substances 0.000 claims description 13
- 239000011521 glass Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 7
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 7
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 5
- 230000003204 osmotic effect Effects 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims description 3
- 230000003444 anaesthetic effect Effects 0.000 claims description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 2
- 239000010453 quartz Substances 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 230000001678 irradiating effect Effects 0.000 claims 1
- 238000010241 blood sampling Methods 0.000 abstract description 2
- 238000011897 real-time detection Methods 0.000 abstract description 2
- 238000001764 infiltration Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 3
- 238000010183 spectrum analysis Methods 0.000 description 3
- -1 Polytetrafluoroethylene Polymers 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002906 medical waste Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a three-way pipeline for monitoring the concentration of substances in blood and a monitoring system. A Y-shaped pipe is arranged in the three-way connecting piece, two branch pipes at the same end of the Y-shaped pipe are respectively connected with the probe pipe and the body fluid pipe, and the other end of the Y-shaped pipe is connected with the detection pipe; the preset position on the detection tube is provided with an irradiation tube. The substance concentration monitoring system comprises a reagent booster, a micro-permeation tube, a spectrum analyzer, a display, a laser emitter, a shading box and the three-way pipeline. The reagent booster is connected with a detection reagent tube, and the other end of the detection reagent tube is connected with a probe tube; one end of the micro-infiltration pipe is used for embedding in the blood vessel of the human body and collecting blood, and the other end is connected with the body fluid pipe. The three-way pipeline can be simultaneously connected with the blood vessel of the patient and the detection reagent, the blood of the patient and the detection reagent are collected together, real-time detection is convenient, and repeated pricking needle blood sampling is avoided.
Description
Technical Field
The invention relates to the technical field of blood substance concentration detection, in particular to a three-way pipeline and a monitoring system for monitoring the concentration of substances in blood.
Background
Hospitalized patients, particularly severe patients and perioperative patients, may have severe clinical consequences and affect the prognosis of patients due to rapid fluctuation of some substances in their blood caused by critical conditions and various stress reactions. At present, medical staff mostly adopt the mode of drawing blood by veins to detect the concentration of blood sugar, antibiotics or narcotics of a patient, firstly use an injector to draw the blood of the patient, then add the blood and a detection reagent into the same detection tube, and then put the detection tube into a detection instrument for detection.
However, the substance concentration in the human body is a variable which changes with time and is influenced by a plurality of factors such as mood, diet, blood sampling amount, proficiency of operators and the like, so that the blood substance concentration value measured in a single time has great randomness. In order to make the measured blood substance concentration value representative, medical staff needs to repeatedly take blood samples by needle puncture for patients, but the intermittent concentration measurement also causes medical pain for patients.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a three-way pipeline and a monitoring system for monitoring the concentration of substances in blood.
In order to realize the purpose of the invention, the following scheme is adopted:
a three-way pipeline for monitoring the concentration of substances in blood comprises a three-way connecting piece, and a probe tube, a body fluid tube and a detection tube which are respectively connected with the three-way connecting piece.
A Y-shaped pipe is arranged in the three-way connecting piece, two branch pipes at the same end of the Y-shaped pipe are respectively connected with the probe pipe and the body fluid pipe, the other end of the Y-shaped pipe is connected with the detection pipe, and female luer connectors are arranged at the other ends of the probe pipe and the body fluid pipe;
the detection tube is provided with an irradiation tube at a preset position, the irradiation tube is a quartz tube or a PMMA tube, a glass tube fixing block is arranged outside the irradiation tube, and a through hole is formed in the side wall of the glass tube fixing block.
Furthermore, the inner diameters of the probe tube, the body fluid tube and the detection tube are all 30-300 mu m, and the wall thickness of the tube is 0.5-2.5 mm.
Furthermore, the three-way pipeline is made of a PTFE (Polytetrafluoroethylene) pipe or other high-strength modified plastic pipes with the material bearing capacity of 3N-15N.
Furthermore, the lengths of the probe tube and the body fluid tube are both within the interval of 0.5m-2.5m, and the length of the detection tube is 0.5m-1.5 m.
A real-time on-line monitoring system for substance concentration comprises a reagent booster, a micro-permeation tube, a spectrum analyzer, a display, a laser emitter, a shading box and the three-way pipeline for monitoring the substance concentration in blood.
The reagent booster is connected with a detection reagent tube, the other end of the detection reagent tube is connected with the probe tube through a female luer connector, and the reagent booster is used for bearing a reagent for detecting the concentration of a substance and pushing the detection reagent into the probe tube;
one end of the micro-osmotic tube is provided with an osmotic membrane, the micro-osmotic tube at the other end is used for embedding into a human body blood vessel and collecting blood, the other end of the micro-osmotic tube is connected with a body fluid tube through a female luer connector, and the micro-osmotic tube is provided with a body fluid driver which is used for pushing the collected blood into the body fluid tube;
furthermore, glass pipe fixed block, irradiation tube are located in the shading box, and laser emitter is connected to the spectral analysis appearance, and the shading box is connected to the laser emitter other end, and matches with the irradiation tube for shine at the irradiation tube through the through-hole under the shading environment, detect the analysis material concentration value.
Furthermore, the other end of the detection tube is connected with a waste liquid treatment mechanism, and the waste liquid treatment mechanism is used for treating waste liquid flowing out of the irradiation tube.
Furthermore, the kit is used for detecting any one of blood sugar concentration, antibiotic concentration and narcotic concentration in blood.
The invention has the beneficial effects that:
1. the three-way pipeline is provided with a probe pipe, a body fluid pipe and a detection pipe, the probe pipe and the body fluid pipe are respectively used for collecting a substance detection reagent and blood of a patient, the reagent and the blood flow into the detection pipe after being mixed by the three-way connecting piece, real-time detection is convenient, the structure is simple, the use is convenient, the inner diameter of the pipe of the three-way pipeline is between 30 and 300 mu m, and a PTFE pipe or other high-strength modified plastic pipes with the bearing capacity between 3 and 15N are used;
2. the body fluid tube is connected with the micro-permeation tube, the permeation film at one end of the micro-permeation tube is used for embedding into a human body blood vessel and collecting blood, the permeation film can enable small molecules such as glucose, water and the like in the blood to pass through, so that the collected blood flows into the body fluid tube under the action of the body fluid driver, and compared with the intermittent blood collection for detecting the substance concentration, the micro-permeation tube is always embedded into the blood vessel of a patient, so that the frequent blood collection operation is reduced;
3. the method utilizes the spectrum analyzer to irradiate the irradiation tube to detect the concentration value of the substance in the blood, and compared with the conventional test paper detection method, the method has the advantages that the detected blood sugar value is more accurate, and the consumed materials are less; the invention is also additionally provided with a waste liquid treatment mechanism which is used for treating the blood waste liquid flowing out of the irradiation tube and treating the medical waste liquid in time, thereby effectively reducing the risk of cross infection in a hospital.
Drawings
FIG. 1 is a plan view of a three-way pipe according to example 1;
FIG. 2 is an enlarged partial perspective view of A in FIG. 1;
FIG. 3 is a plan perspective view of the three-way connection member of embodiment 1;
FIG. 4 is a schematic plan view of the real-time on-line monitoring system for substance concentration in example 2;
FIG. 5 is a flow chart of the liquid flow in example 2.
Detailed Description
Example 1
As shown in fig. 1, the present embodiment provides a three-way pipeline for monitoring the concentration of a substance in blood, which includes a three-way connector 4, and a probe tube 1, a body fluid tube 2, and a detection tube 3 respectively connected to the three-way connector 4.
Specifically, as shown in fig. 3, a Y-shaped tube 41 is arranged in the three-way connecting piece 4, two branch tubes at the same end of the Y-shaped tube 41 are respectively connected with the probe tube 1 and the body fluid tube 2, the other end of the Y-shaped tube 41 is connected with the detection tube 3, the other ends of the probe tube 1 and the body fluid tube 2 are both provided with female luer connectors 11, and for convenience of use, the two female luer connectors 11 are different in color.
Specifically, as shown in fig. 2, an irradiation tube 31 is arranged at a preset position on the detection tube 3, the distance between the irradiation tube 31 and the three-way connecting piece 4 is 15cm-30cm, a glass tube fixing block 32 is arranged outside the irradiation tube 31, a through hole 321 is arranged on the side wall of the glass tube fixing block 32, and the irradiation tube 31 is matched with a spectrum analyzer and used for detecting the concentration of a substance.
More specifically, the probe tube 1, the body fluid tube 2 and the detection tube 3 are all 30-300 μm, the wall thickness of the tubes is 0.5-2.5 mm, the three-way pipeline is made of PTFE tubes or other high-strength modified plastic tubes with the material bearing capacity of 3-15N, the length of the probe tube 1 and the length of the body fluid tube 2 are all within the range of 0.5-2.5 m, and the length of the detection tube 3 is 0.5-1.5 m.
As one preferred embodiment, the three-way pipeline is a PTFE (Polytetrafluoroethylene) pipe made of a material with the bearing capacity of 10N, the inner diameters of the probe pipe 1, the body fluid pipe 2 and the detection pipe 3 are all 300 mu m, the wall thicknesses of the pipes are all 1.3mm, the lengths of the probe pipe 1 and the body fluid pipe 2 are all 0.59m, and the length of the detection pipe 3 is 1.2 m.
Example 2
As shown in fig. 4, the present embodiment provides a real-time online monitoring system for substance concentration, which comprises a reagent booster 5, a micro-permeation tube 6, a spectrum analyzer, a display, a laser emitter, a light-shielding box and the three-way tube for monitoring the substance concentration in blood in embodiment 1.
Specifically, the reagent booster 5 is connected to a detection reagent tube 51, the other end of the detection reagent tube 51 is connected to the probe tube 1 via a female luer 11, and the reagent booster 5 is used for loading a reagent for detecting the concentration of a substance and pushing the detection reagent into the probe tube 1.
Specifically, one end of the micro-osmotic tube 6 is provided with an osmotic membrane 62, the micro-osmotic tube 6 at the one end is used for embedding into a human blood vessel and collecting blood, the osmotic membrane 62 can enable small molecules such as glucose and water in the blood to pass through, the other end of the micro-osmotic tube 6 is connected with the body fluid tube 2 through a female luer connector 11, the micro-osmotic tube 6 is provided with a body fluid driver 61, and the body fluid driver 61 is used for pushing the collected blood into the body fluid tube 2.
Specifically, shading box both ends are equipped with the through-hole, and laser emitter is connected to the lateral wall, and the spectral analysis appearance is connected to the laser emitter other end, and the other end is inserted from shading box one end to detecting tube 3, and glass pipe fixed block 32, irradiation tube 31 set up in the shading box, and glass pipe fixed block 32 is used for fixed irradiation tube 31, and laser emitter sets up towards through-hole 321, and under the shading environment, laser emitter passes through-hole 321 and shines at irradiation tube 31, and the spectral analysis appearance just can detect the material concentration value.
More specifically, the other end of the detection tube 3 is connected to a waste liquid treatment mechanism 7, and the waste liquid treatment mechanism 7 is used for treating waste liquid flowing out from the irradiation tube 31.
More specifically, the method is used for detecting any one of blood glucose concentration, antibiotic concentration and anesthetic concentration in blood.
As shown in fig. 5, the liquid flow route of the present embodiment is: the blood passes through the osmotic membrane 62 and the micro-osmotic tube 6 in sequence and then flows into the body fluid tube 2 and the three-way connecting piece 4 under the assistance of the body fluid driver 61; the detection reagent flows into the detection reagent pipe 51, the probe pipe 1 and the three-way connecting piece 4 from the reagent booster 5 in sequence; the blood and the detection reagent flow into the detection tube 3 together after being mixed in the three-way connecting piece 4.
When in use, the control switch of the spectrum analyzer is opened, the laser irradiates the irradiation tube 31 through the through hole 321, the concentration value of the substance in the blood can be detected, and the concentration value of the substance can be directly seen on the display; the waste liquid flowing out from the irradiation tube 31 continues to flow along the detection tube 3 into the waste liquid treatment mechanism 7.
The above embodiments are only for illustrating the technical ideas and features of the present invention, and are not meant to be exclusive or limiting of the present invention. It will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the scope of the invention.
Claims (7)
1. A three-way pipeline for monitoring the concentration of substances in blood is characterized by comprising a three-way connecting piece (4), and a probe tube (1), a body fluid tube (2) and a detection tube (3) which are respectively connected with the three-way connecting piece (4);
a Y-shaped pipe (41) is arranged in the three-way connecting piece (4), two branch pipes at the same end of the Y-shaped pipe (41) are respectively connected with the probe pipe (1) and the body fluid pipe (2), the other end of the Y-shaped pipe (41) is connected with the detection pipe (3), and female luer connectors (11) are arranged at the other ends of the probe pipe (1) and the body fluid pipe (2);
an irradiation tube (31) is arranged at a preset position on the detection tube (3), the irradiation tube (31) is a quartz tube or a PMMA tube, a glass tube fixing block (32) is arranged outside the irradiation tube (31), and a through hole (321) is formed in the side wall of the glass tube fixing block (32).
2. The three-way tube for monitoring the concentration of substances in blood according to claim 1, wherein the inner diameters of the probe tube (1), the body fluid tube (2) and the detection tube (3) are all 30 μm to 300 μm, and the wall thickness of the tube is all 0.5mm to 2.5 mm.
3. The three-way tube for monitoring the concentration of substances in blood according to claim 1 or 2, wherein the three-way tube is made of PTFE tube or other high-strength modified plastic tube with the material bearing capacity of 3N-15N.
4. The three-way tube for monitoring the concentration of substances in blood according to claim 3, wherein the probe tube (1) and the body fluid tube (2) have lengths within the interval of 0.5m to 2.5m, and the detection tube (3) has a length within the interval of 0.5m to 1.5 m.
5. A real-time on-line monitoring system for substance concentration is characterized by comprising a reagent booster (5), a micro-permeation tube (6), a spectrum analyzer, a display, a laser emitter, a shading box and a three-way pipeline for monitoring the substance concentration in blood according to claim 4;
the reagent booster (5) is connected with a detection reagent tube (51), the other end of the detection reagent tube (51) is connected with the probe tube (1) through a female luer connector (11), and the reagent booster (5) is used for loading a reagent for detecting the concentration of a substance and pushing the detection reagent into the probe tube (1);
one end of the micro-osmotic tube (6) is provided with an osmotic membrane (62), the micro-osmotic tube (6) at the other end is used for embedding into a human body blood vessel and collecting blood, the other end of the micro-osmotic tube (6) is connected with the body fluid tube (2) through a female luer connector (11), the micro-osmotic tube (6) is provided with a body fluid driver (61), and the body fluid driver (61) is used for pushing the collected blood into the body fluid tube (2);
the glass tube fixing block (32) and the irradiation tube (31) are arranged in the shading box, the spectrum analyzer is connected with the laser emitter, the other end of the laser emitter is connected with the shading box and matched with the irradiation tube (31) and used for irradiating the irradiation tube (31) through the through hole (321) in the shading environment to detect the concentration value of the substance to be analyzed.
6. The system for real-time online monitoring of the concentration of a substance according to claim 5, wherein the other end of the detection tube (3) is connected with a waste liquid treatment mechanism (7), and the waste liquid treatment mechanism (7) is used for treating waste liquid flowing out of the irradiation tube (31).
7. The system for real-time on-line monitoring of substance concentration according to claim 5 or 6, is used for detecting any one of blood glucose concentration, antibiotic concentration and anesthetic concentration in blood.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2021111865560 | 2021-10-12 | ||
| CN202111186556.0A CN113768500A (en) | 2021-10-12 | 2021-10-12 | Three-way pipeline and monitoring system for monitoring concentration of substances in blood |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114699073A true CN114699073A (en) | 2022-07-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111186556.0A Pending CN113768500A (en) | 2021-10-12 | 2021-10-12 | Three-way pipeline and monitoring system for monitoring concentration of substances in blood |
| CN202210377035.1A Pending CN114699073A (en) | 2021-10-12 | 2022-04-12 | Three-way pipeline and monitoring system for monitoring concentration of substances in blood |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111186556.0A Pending CN113768500A (en) | 2021-10-12 | 2021-10-12 | Three-way pipeline and monitoring system for monitoring concentration of substances in blood |
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| Country | Link |
|---|---|
| CN (2) | CN113768500A (en) |
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2021
- 2021-10-12 CN CN202111186556.0A patent/CN113768500A/en active Pending
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2022
- 2022-04-12 CN CN202210377035.1A patent/CN114699073A/en active Pending
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| Publication number | Publication date |
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| CN113768500A (en) | 2021-12-10 |
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