CN114518239B - Cancer tissue section sampling device for tumor treatment - Google Patents
Cancer tissue section sampling device for tumor treatment Download PDFInfo
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- CN114518239B CN114518239B CN202210153514.5A CN202210153514A CN114518239B CN 114518239 B CN114518239 B CN 114518239B CN 202210153514 A CN202210153514 A CN 202210153514A CN 114518239 B CN114518239 B CN 114518239B
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- fixedly connected
- disc
- cancer tissue
- shell
- tumor treatment
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- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 65
- 201000011510 cancer Diseases 0.000 title claims abstract description 36
- 238000005070 sampling Methods 0.000 title claims abstract description 20
- 238000007790 scraping Methods 0.000 claims abstract description 12
- 238000001125 extrusion Methods 0.000 claims abstract description 5
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 9
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 9
- 241001330002 Bambuseae Species 0.000 claims description 9
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 9
- 239000011425 bamboo Substances 0.000 claims description 9
- 230000003028 elevating effect Effects 0.000 claims description 7
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 230000001174 ascending effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 6
- 230000017074 necrotic cell death Effects 0.000 abstract description 3
- 230000001338 necrotic effect Effects 0.000 abstract description 2
- 230000003647 oxidation Effects 0.000 abstract description 2
- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- 238000010301 surface-oxidation reaction Methods 0.000 abstract description 2
- 208000035212 Ring chromosome 19 syndrome Diseases 0.000 description 4
- 210000004881 tumor cell Anatomy 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 1
- 208000035480 Ring chromosome 8 syndrome Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004066 metabolic change Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000010627 oxidative phosphorylation Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention provides a cancer tissue slice sampling device for tumor treatment, and relates to the field of tumors. The cancer tissue slice sampling device for tumor treatment comprises a base station, wherein an auxiliary arm is fixedly connected to the upper end of the base station, a chute shell is slidably connected to the top end of the base station, clamping wrenches are rotatably connected to the two sides of the chute shell, a supporting rod is connected to the lower end of each clamping wrenches in a contact mode, the supporting rod is slidably connected with the auxiliary arm, a top spring is sleeved on the surface of each supporting rod, the top spring is arranged between the auxiliary arm and the chute shell, a telescopic rod is fixedly connected to the lower end of each supporting rod, and a squeezing ring is fixedly connected to the lower end of each telescopic rod. This cancer tissue section sampling device for tumour treatment presses the bracing piece through rotatory clamp wrench, makes the cancer tissue of base top can be pressed by the extrusion ring and fixes, and through scraping the board side-to-side slip of rubbing, makes the tissue of surface oxidation necrosis can peel off, has reached the effect of selecting to peel off the sample cancer tissue, has solved the easy oxidation of cancer tissue surface and necrotic problem.
Description
Technical Field
The invention relates to the field of tumors, in particular to a cancer tissue slice sampling device for tumor treatment.
Background
Tumors refer to new organisms formed by local tissue cell proliferation under the action of various tumorigenic factors, because the new organisms are often in the form of occupying massive protrusions, also called neoplasms. It has been found that tumor cells undergo metabolic changes that differ from normal cells, while tumor cells themselves can adapt to changes in metabolic environment by switching between glycolysis and oxidative phosphorylation.
Most tumors are subjected to slicing study or preservation treatment after excision, however, the inside of the tumor is composed of cancer tissues, and in order to prevent infection caused by direct contact, a device for always avoiding direct release of sampling slices is designed.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a cancer tissue slice sampling device for tumor treatment, which solves the problems that the surface of a cancer tissue is easy to oxidize and necrose, the cancer tissue slice is not in a regular shape, the research and the storage are inconvenient, and the cancer tissue cannot be spread on a loading slice by using forceps.
In order to achieve the above purpose, the invention is realized by the following technical scheme: the utility model provides a cancer tissue section sampling device for tumour treatment, including the base, base upper end fixedly connected with auxiliary arm, base top sliding connection has the spout shell, spout shell both sides are rotated and are connected with the clamp wrench, clamp wrench lower extreme contact connection has the bracing piece, bracing piece and auxiliary arm sliding connection, the bracing piece surface has cup jointed the jack spring, the jack spring is between auxiliary arm and spout shell, bracing piece lower extreme fixedly connected with telescopic link, telescopic link lower extreme fixedly connected with squeeze ring, spout shell's inside groove sliding connection has the sliding to the piece, sliding to piece inside groove threaded connection has the sleeve, sleeve lower extreme hinge has and cuts the plate, sleeve inside groove sliding connection has the ejector pin, ejector pin and cut plate contact connection, sleeve upper end cover is connected with the loosening spring, loosening spring upper end and ejector pin contact connection, spout shell inside groove sliding connection has the spliced pole, spliced pole upper end fixed connection promotes the key, spliced pole lower extreme fixedly connected with an operating cylinder, an operating cylinder inside groove fixedly connected with power motor, power motor output fixedly connected with elevating disc, the one end sliding connection who keeps away from the power motor has the push plate, rotating guide cylinder fixedly connected with the slide plate contact block is connected with the slide plate, the fixed distance slide plate is connected with the slide holder, the fixed connection has the slide plate contact plate to the fixed distance between the slide plate, the slide plate is connected with the slide plate.
Preferably, the shape of the chute shell is a cuboid empty shell, gaps are formed in two sides of the cuboid, the clamping wrench rotates in the gaps, a slide way is formed in the bottom end of the chute shell, and the pushing block slides in the slide way.
Preferably, the shape of the scraping and rubbing plate is elliptical, the upper end of the scraping and rubbing plate is provided with a groove, the ejector rod slides in the groove, and the two groups of scraping and rubbing plates are respectively arranged on two sides of the movable column.
Preferably, the sleeve is a hollow cylinder, a linear groove is formed in the upper end of the cylinder, threads are formed in the outer surface of the upper end of the cylinder, and the threads are meshed with the sliding block.
Preferably, one end of the upper end of the lifting disc, which is close to the power motor, is a disc, and six round rods are fixedly connected with the disc next time, and the surfaces of the round rods are in sliding connection with the torque disc.
Preferably, the top end of the torque disc is a sliding disc, the peripheral surface of the sliding disc is in sliding connection with the operating cylinder, the lower end surface of the sliding disc is fixedly connected with a main shaft, the surface of the main shaft is fixedly connected with a springboard, the springboard is fan-shaped, the cross section of the springboard is triangular, and the lower end of the main shaft is fixedly connected with a disc.
Preferably, the outline of the rotary cutting disc is a spiral ascending plane, the lowest end of the plane is provided with a cutting edge, and the whole overlooking plane is a disc.
Compared with the prior art, the invention has the following beneficial effects:
1. This cancer tissue section sampling device for tumour treatment presses the bracing piece through rotatory clamp wrench, makes the cancer tissue of base top can be pressed by the extrusion ring and fixes, and through scraping the board side-to-side slip of rubbing, makes the tissue of surface oxidation necrosis can peel off, has reached the effect of selecting to peel off the sample cancer tissue, has solved the easy oxidation of cancer tissue surface and necrotic problem.
2. This cancer tissue section sampling device for tumour treatment carries out rotatory section sample to cancer tissue through circular rotary-cut dish, makes regular convenient research of sample shape and storage, through placing loading piece in rotary-cut dish top, makes the influence that reduces the metastasis and bring on the slide glass that the sample wafer after the cutting directly shifts, has reached the effect that direct section carried out the loading, has solved the problem that cancer tissue section is inconvenient research and storage of irregular shape.
3. The cancer tissue slice sampling device for tumor treatment makes contact with the impact guide ring when the rotary-cut disc rotates, so that the rotary-cut disc rotates for a circle and then is lifted upwards, and the sample slice can be directly lifted to the surface of the loading slice after being cut through the rotary-cut disc rotating for a circle, thereby achieving the effect that the slice is not contacted for transfer, and solving the problem that cancer tissues cannot be tiled on the loading slice by using forceps.
Drawings
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a schematic view of the structure of the operating cylinder of the present invention;
FIG. 3 is a schematic view of a chute housing according to the present invention;
FIG. 4 is a schematic view of a support bar according to the present invention;
FIG. 5 is a semi-sectional view of an actuator cylinder according to the present invention;
FIG. 6 is a schematic view of the structure of a rotary cutting disc according to the present invention;
Fig. 7 is a half cross-sectional view of a chute housing according to the invention.
The device comprises a base platform-1, an auxiliary arm-2, a chute shell-3, a clamping wrench-4, a supporting rod-5, a top spring-6, a telescopic rod-7, an extrusion ring-8, a sliding block-9, a sleeve-10, a scratch board-11, a push rod-12, a loosening spring-13, a moving column-14, an operating cylinder-15, a power motor-16, a lifting disc-17, a torque disc-18, a guide ring-19, a baffle plate-20, a contraction spring-21, a rotary cutting disc-22, an pushing block-23, a long rod-24, a loading sheet-25 and a pushing key-26.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
As shown in fig. 1-7, a cancer tissue slice sampling device for tumor treatment comprises a base 1, an auxiliary arm 2 is fixedly connected to the upper end of the base 1, a chute shell 3 is slidably connected to the top end of the base 1, clamping wrenches 4 are rotatably connected to the two sides of the chute shell 3, a supporting rod 5 is connected to the lower end of the clamping wrenches 4 in a contact manner, the supporting rod 5 is slidably connected with the auxiliary arm 2, a top spring 6 is sleeved on the surface of the supporting rod 5, the top spring 6 is arranged between the auxiliary arm 2 and the chute shell 3, a telescopic rod 7 is fixedly connected to the lower end of the supporting rod 5, a squeezing ring 8 is fixedly connected to the lower end of the telescopic rod 7, a sliding block 9 is slidably connected to an inner groove of the chute shell 3, a sleeve 10 is in a hollow cylinder shape, a linear groove is formed in the upper end of the cylinder, threads are formed in the outer surface of the upper end of the cylinder, the threads are meshed with the sliding block 9, and the sleeve 10 can adjust the height in the chute shell 3 by controlling the moving direction of the inner groove mechanism.
The lower extreme of sleeve 10 articulates there is a piece of board 11 of rubbing, sleeve 10 inside groove sliding connection has ejector pin 12, ejector pin 12 and a piece of board 11 contact connection of rubbing, sleeve 10 upper end cover has loosened spring 13, it is connected with ejector pin 12 contact to loosen spring 13 upper end, chute boot 3 inside groove sliding connection has movable column 14, a piece of board 11 appearance of rubbing is oval, a piece of board 11 upper end of rubbing is set up flutedly, ejector pin 12 slides in the recess, a piece of board 11 of rubbing has two sets of respectively in movable column 14 both sides altogether, a piece of board 11 of rubbing can clear away tumor surface necrosis and oxidized cancer tissue.
The upper end fixedly connected with push button 26 of removal post 14, the lower extreme fixedly connected with operation section of thick bamboo 15 of removal post 14, operation section of thick bamboo 15 inside groove fixedly connected with power motor 16, power motor 16 output fixedly connected with elevating disc 17, the one end sliding connection who keeps away from power motor 16 of elevating disc 17 has torque disc 18, the one end that is close to power motor 16 on the elevating disc 17 is the disc, six round bars of disc fixedly connected with next time, round bar surface and torque disc 18 sliding connection, elevating disc 17 can pass through the orbit of cutter reciprocates.
The torque disc 18 is rotationally connected with the operation cylinder 15, the top end of the torque disc 18 is a sliding disc, the peripheral surface of the sliding disc is in sliding connection with the operation cylinder 15, the lower end surface of the sliding disc is fixedly connected with a main shaft, the surface of the main shaft is fixedly connected with a springboard, the springboard is fan-shaped, the cross section of the springboard is triangular, the lower end of the main shaft is fixedly connected with a disc, and the torque disc 18 can enable a cutter to be lifted upwards after rotating for a circle through rotation, so that cancer tissue transfer is facilitated.
The inside groove fixedly connected with guide ring 19 of an operation section of thick bamboo 15, guide ring 19 and torque disc 18 contact connection, operation section of thick bamboo 15 inside groove fixedly connected with baffle 20, torque disc 18 surface has cup jointed shrink spring 21, shrink spring 21 and baffle 20 contact, torque disc 18 bottom fixedly connected with rotary-cut dish 22, rotary-cut dish 22 appearance is the plane of spiral rising, the cutting edge has been seted up to the plane bottommost, the plane is whole to be the disc overlook, rotary-cut dish 22 mainly has the effect of the cancer tissue sample of slice.
The lower extreme sliding connection of spout shell 3 has pushing away piece 23, and spout shell 3 appearance is cuboid empty shell, and the breach has been seted up to cuboid both sides, and clamp wrench 4 rotates in the breach, and the slide has been seted up to spout shell 3 bottom, pushes away piece 23 and slides in the slide, and spout shell 3 has the effect that provides the convenient device control of track slip.
The lower end of the pushing block 23 is fixedly connected with a long rod 24, and one end of the long rod 24 away from the pushing block 23 is fixedly connected with a loading plate 25.
When the rotary cutting machine is used, firstly, tumors are placed above the base 1, the chute shell 3 is adjusted to a proper height, the rotary clamping wrench 4 presses the supporting rod 5, the telescopic rod 7 drives the extrusion ring 8 to clamp the tumors, the push rod 12 is pressed to extrude the scraping plate 11, the scraping plate 11 is vertical, the sliding push rod 12 slides through the sleeve 10 and the sliding block 9, the scraping plate 11 scrapes tissues on the surfaces of the tumors, the pushing key 26 drives the movable column 14 to slide on the chute shell 3, the power motor 16 is started to drive the lifting disc 17 to rotate, the torque disc 18 drives the rotary cutting disc 22 to rotate, the guide ring 19 is touched after the torque disc 18 rotates for a circle, the telescopic rod 21 is contracted after the lifting to extrude the torque disc 18 to reset, the long rod 24 is pushed before the power motor 16 is started to enable the pushing block 23 to slide in the chute shell 3, the loading disc 25 is sleeved above the rotary cutting disc 22, and the rotationally separated cancer tissues are transferred to the surface of the loading disc 25 after the rotary cutting disc 22 is lifted.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The utility model provides a cancer tissue section sampling device for tumour treatment, includes base station (1), its characterized in that: the novel sliding support is characterized in that an auxiliary arm (2) is fixedly connected to the upper end of the base station (1), a chute shell (3) is slidably connected to the top end of the base station (1), clamping spanners (4) are rotatably connected to two sides of the chute shell (3), a supporting rod (5) is connected to the lower end of each clamping spanners (4), the supporting rod (5) is slidably connected with the auxiliary arm (2), a top spring (6) is sleeved on the surface of each supporting rod (5), the top spring (6) is arranged between the auxiliary arm (2) and the chute shell (3), a telescopic rod (7) is fixedly connected to the lower end of each supporting rod (5), an extrusion ring (8) is fixedly connected to the lower end of each telescopic rod (7), a sliding block (9) is slidably connected to an inner groove of each chute shell (3), a sleeve (10) is hinged to the lower end of each sleeve (10), an inner groove of each sleeve (10) is slidably connected with a push rod (12), each push rod (12) is in contact connection with each scraping plate (11), a spring (13) is sleeved on the upper end of each sleeve (10), and the upper end of each releasing spring (13) is connected to each push rod (12) in contact mode.
The utility model provides a chute shell (3) inside groove sliding connection has movable column (14), movable column (14) upper end fixedly connected with push button (26), movable column (14) lower extreme fixedly connected with operation section of thick bamboo (15), operation section of thick bamboo (15) inside groove fixedly connected with motor (16), motor (16) output fixedly connected with elevating disc (17), the one end sliding connection who keeps away from motor (16) elevating disc (17) has torque disc (18), torque disc (18) and operation section of thick bamboo (15) swivelling joint, the inside groove fixedly connected with guide ring (19) of operation section of thick bamboo (15), guide ring (19) and torque disc (18) contact connection, operation section of thick bamboo (15) inside groove fixedly connected with baffle (20), torque disc (18) surface cup joint has shrink spring (21), shrink spring (21) and baffle (20) contact, torque disc (18) bottom fixedly connected with rotary-cut dish (22), the one end sliding connection of chute shell (3) has push block (23), push block (23) lower extreme fixedly connected with stock (24), the one end fixedly connected with stock (24) of keeping away from loading piece (25).
2. The cancer tissue slice sampling apparatus for tumor treatment according to claim 1, wherein: the appearance of spout shell (3) is the cuboid empty shell, and the breach has been seted up to cuboid both sides, and clamp spanner (4) rotate in the breach, and the slide has been seted up to spout shell (3) bottom, pushes away and carries out piece (23) and slides in the slide.
3. The cancer tissue slice sampling apparatus for tumor treatment according to claim 1, wherein: the shape of the scraping and rubbing plate (11) is elliptical, a groove is formed in the upper end of the scraping and rubbing plate (11), the ejector rod (12) slides in the groove, and the scraping and rubbing plate (11) has two groups which are respectively arranged on two sides of the movable column (14).
4. The cancer tissue slice sampling apparatus for tumor treatment according to claim 1, wherein: the sleeve (10) is a hollow cylinder, a linear groove is formed in the upper end of the cylinder, threads are formed in the outer surface of the upper end of the cylinder, and the threads are meshed with the sliding block (9).
5. The cancer tissue slice sampling apparatus for tumor treatment according to claim 1, wherein: the lifting disc (17) is characterized in that one end, close to the power motor (16), of the upper end of the lifting disc is a disc, six round rods are fixedly connected to the lower end of the disc, and the surfaces of the round rods are in sliding connection with the torque disc (18).
6. The cancer tissue slice sampling apparatus for tumor treatment according to claim 1, wherein: the top end of the torque disc (18) is a sliding disc, the peripheral surface of the sliding disc is in sliding connection with the operation cylinder (15), the lower end surface of the sliding disc is fixedly connected with a main shaft, the surface of the main shaft is fixedly connected with a springboard, the springboard is fan-shaped, the cross section of the springboard is triangular, and the lower end of the main shaft is fixedly connected with a disc.
7. The cancer tissue slice sampling apparatus for tumor treatment according to claim 1, wherein: the outline of the rotary cutting plate (22) is a spiral ascending plane, the lowest end of the plane is provided with a cutting edge, and the whole overlooking plane is a disc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210153514.5A CN114518239B (en) | 2022-02-18 | 2022-02-18 | Cancer tissue section sampling device for tumor treatment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210153514.5A CN114518239B (en) | 2022-02-18 | 2022-02-18 | Cancer tissue section sampling device for tumor treatment |
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| Publication Number | Publication Date |
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| CN114518239A CN114518239A (en) | 2022-05-20 |
| CN114518239B true CN114518239B (en) | 2024-06-18 |
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| CN202210153514.5A Active CN114518239B (en) | 2022-02-18 | 2022-02-18 | Cancer tissue section sampling device for tumor treatment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN118464498A (en) * | 2024-05-09 | 2024-08-09 | 徐彦之 | A slicing device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104792571A (en) * | 2014-01-17 | 2015-07-22 | 杨涛 | Breast cancer breast-conserving specimen sampling and measuring platform |
| CN108324326A (en) * | 2018-01-10 | 2018-07-27 | 程晓磊 | A kind of oncology living body sampling conservator |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5703492B2 (en) * | 2010-08-18 | 2015-04-22 | サクラ精機株式会社 | Microtome and cryostat |
| CN205120401U (en) * | 2015-10-20 | 2016-03-30 | 郭培民 | Medical pathological tissue selected table |
| EP3681998A1 (en) * | 2017-09-11 | 2020-07-22 | IMBA-Institut für Molekulare Biotechnologie GmbH | Tumor organoid model |
| CN208228960U (en) * | 2017-12-08 | 2018-12-14 | 南京医科大学 | A kind of medical treatment tumor sampling device |
| CN207881975U (en) * | 2018-02-10 | 2018-09-18 | 王广成 | Tumor biopsy positioning device |
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- 2022-02-18 CN CN202210153514.5A patent/CN114518239B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104792571A (en) * | 2014-01-17 | 2015-07-22 | 杨涛 | Breast cancer breast-conserving specimen sampling and measuring platform |
| CN108324326A (en) * | 2018-01-10 | 2018-07-27 | 程晓磊 | A kind of oncology living body sampling conservator |
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Effective date of registration: 20240521 Address after: 210009 Nanjing, Jiangsu province Xuanwu District 100 Ting 42 Applicant after: JIANGSU CANCER Hospital Country or region after: China Address before: 100000 10 / F, 101, building 1, courtyard 3, fenghuangzui street, Fengtai District, Beijing Applicant before: Shen Chengcheng Country or region before: China |
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