CN114504525A - A kind of acne cream containing components of North American witch hazel and preparation method thereof - Google Patents
A kind of acne cream containing components of North American witch hazel and preparation method thereof Download PDFInfo
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- CN114504525A CN114504525A CN202210321186.5A CN202210321186A CN114504525A CN 114504525 A CN114504525 A CN 114504525A CN 202210321186 A CN202210321186 A CN 202210321186A CN 114504525 A CN114504525 A CN 114504525A
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- Prior art keywords
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- acne
- extract
- hamamelis virginiana
- peg
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 44
- 206010000496 acne Diseases 0.000 title claims abstract description 44
- 239000006071 cream Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 241000208680 Hamamelis mollis Species 0.000 title claims description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 36
- 241000208681 Hamamelis virginiana Species 0.000 claims abstract description 26
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 240000004534 Scutellaria baicalensis Species 0.000 claims abstract description 14
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims abstract description 14
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 13
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 12
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 12
- 229940036350 bisabolol Drugs 0.000 claims abstract description 12
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940081733 cetearyl alcohol Drugs 0.000 claims abstract description 12
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930182478 glucoside Natural products 0.000 claims abstract description 12
- 150000008131 glucosides Chemical class 0.000 claims abstract description 12
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims abstract description 12
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940100460 peg-100 stearate Drugs 0.000 claims abstract description 12
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 12
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 10
- XYTHHAXRVHHXKO-JIUYZRCGSA-N 18-[(2r,3s,4r,5r)-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxyoctadecanoic acid;ethanol Chemical compound CCO.COC1O[C@H](CO)[C@@H](OCCCCCCCCCCCCCCCCCC(O)=O)[C@H](O)[C@H]1O XYTHHAXRVHHXKO-JIUYZRCGSA-N 0.000 claims abstract description 10
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 10
- SSISHJJTAXXQAX-ZETCQYMHSA-N L-ergothioneine Chemical compound C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-ZETCQYMHSA-N 0.000 claims abstract description 10
- 229940093497 ergothioneine Drugs 0.000 claims abstract description 10
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000230 xanthan gum Substances 0.000 claims abstract description 10
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 10
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 10
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 10
- 241000202807 Glycyrrhiza Species 0.000 claims abstract description 9
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000010684 cajeput oil Substances 0.000 claims abstract description 8
- 229960001915 hexamidine Drugs 0.000 claims abstract description 7
- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000003755 preservative agent Substances 0.000 claims abstract description 7
- 230000002335 preservative effect Effects 0.000 claims abstract description 7
- 229940084750 sophora flavescens root extract Drugs 0.000 claims abstract description 6
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract 3
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 24
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 20
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 13
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 12
- 229960005323 phenoxyethanol Drugs 0.000 claims description 12
- 229960003415 propylparaben Drugs 0.000 claims description 12
- 229940075529 glyceryl stearate Drugs 0.000 claims description 11
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 9
- 239000005944 Chlorpyrifos Substances 0.000 claims description 9
- SBPBAQFWLVIOKP-UHFFFAOYSA-N chlorpyrifos Chemical compound CCOP(=S)(OCC)OC1=NC(Cl)=C(Cl)C=C1Cl SBPBAQFWLVIOKP-UHFFFAOYSA-N 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 8
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 8
- 229960002216 methylparaben Drugs 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 7
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 6
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 6
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 6
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 4
- 238000000265 homogenisation Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000005086 pumping Methods 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 3
- 229940118846 witch hazel Drugs 0.000 claims description 3
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 claims description 2
- NMAQSOQOKDHXGW-NOVBDOAMSA-N C(CCCCCCCCCCCCCCCCC)(=O)O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C(CCCCCCCCCCCCCCCCC)(=O)O.C(CCCCCCCCCCCCCCCCC)(=O)O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO Chemical compound C(CCCCCCCCCCCCCCCCC)(=O)O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C(CCCCCCCCCCCCCCCCC)(=O)O.C(CCCCCCCCCCCCCCCCC)(=O)O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO NMAQSOQOKDHXGW-NOVBDOAMSA-N 0.000 claims description 2
- 241000378467 Melaleuca Species 0.000 claims description 2
- 230000003255 anti-acne Effects 0.000 claims description 2
- 229960003993 chlorphenesin Drugs 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003086 colorant Substances 0.000 claims 2
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 claims 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 claims 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 claims 1
- 241000721623 Myzus Species 0.000 claims 1
- 241000207929 Scutellaria Species 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000003020 moisturizing effect Effects 0.000 abstract description 7
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 230000004054 inflammatory process Effects 0.000 abstract description 5
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 4
- 208000026935 allergic disease Diseases 0.000 abstract description 4
- 230000007815 allergy Effects 0.000 abstract description 4
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 abstract description 3
- 229940100524 ethylhexylglycerin Drugs 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 8
- 210000003491 skin Anatomy 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 241000246044 Sophora flavescens Species 0.000 description 4
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 3
- 241000186427 Cutibacterium acnes Species 0.000 description 3
- 240000003553 Leptospermum scoparium Species 0.000 description 3
- 235000015459 Lycium barbarum Nutrition 0.000 description 3
- 208000003351 Melanosis Diseases 0.000 description 3
- 229940055019 propionibacterium acne Drugs 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- SSISHJJTAXXQAX-UHFFFAOYSA-N 5-[2-carboxy-2-(trimethylazaniumyl)ethyl]-1h-imidazole-2-thiolate Chemical compound C[N+](C)(C)C(C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-UHFFFAOYSA-N 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 description 2
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 229940011871 estrogen Drugs 0.000 description 2
- 239000000262 estrogen Substances 0.000 description 2
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000003405 preventing effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229940084760 glycyrrhiza inflata root extract Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an acne-removing cream containing hamamelis virginiana components, which comprises 4-8 parts of propylene glycol, 2-5 parts of ethylhexyl palmitate, 1-4 parts of cetearyl alcohol, 1-3 parts of cetearyl glucoside, 0.5-1 part of glycerol stearate, 0.25-0.75 part of PEG-100 stearate, 0.6-1 part of PEG-20 methyl glucose sesquistearate, 0.4-0.8 part of butanediol, 0.1-0.3 part of glycyrrhiza inflate extract, 0.2-0.5 part of scutellaria baicalensis root extract, 2-4 parts of hamamelis virginiana extract and 0.5-0.8 part of ethylhexylglycerin, 0.4-0.7 parts of sophora flavescens root extract, 0.2-0.5 parts of bisabolol, 0.4-0.6 parts of ergothioneine, 0.3-0.8 parts of 1, 2-hexanediol, 0.2-0.4 parts of tocopherol acetate, 0.1-0.2 parts of salicylic acid, 0.2-0.5 parts of xanthan gum, 0.05-0.1 parts of pH regulator, 0.1-0.4 parts of cajeput oil, 0.1-0.2 parts of hexamidine dihydrochloride, 0.75-1.38 parts of preservative and the balance of water. The invention also discloses a corresponding preparation method of the acne-removing cream. The invention has synergistic effect, and has the effects of resisting inflammation, removing acne, tranquilizing, resisting allergy, moisturizing, locking water and the like.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to acne-removing face cream and a preparation method thereof.
Background
In adolescent human body, the male hormone is easy to be over-secreted, the sebaceous gland is hypertrophic, the sebum is over-secreted, the pore is easy to be excreted unsmoothly, and the sebum is accumulated in the hair follicle to form the lipid plug. Prolonged secondary bacterial infection causes inflammatory reactions around the pilosebaceous glands, forming papules or pustules. At present, tea tree essential oil is generally used as a main functional raw material in the traditional acne removing products, but the tea tree essential oil has the characteristics of oiliness, dryness, neutrality and mixability in skin classification, and the tea tree essential oil has a poor acne removing effect on oiliness skin.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the face cream which takes the ingredients of Hamamelis virginiana as main functional raw materials and has certain acne removing effect on various skins.
The second purpose of the invention is to provide a preparation method of the acne-removing cream.
In order to solve the technical problems, the invention adopts the following technical scheme: an acne-removing cream containing hamamelis virginiana components is prepared from the following components in percentage by weight:
4 to 8 parts of propylene glycol, 2 to 5 parts of ethylhexyl palmitate, 1 to 4 parts of cetearyl alcohol, 1 to 3 parts of cetearyl glucoside, 0.5 to 1 part of glyceryl stearate, 0.25 to 0.75 part of PEG-100 stearate, 0.6 to 1 part of PEG-20 methyl glucose sesquistearate, 0.4 to 0.8 part of butylene glycol, 0.1 to 0.3 part of licorice root (IGCYRRHIZA INFLATA) root extract, 0.2 to 0.5 part of Scutellaria BAICALENSIS (SCUTELLARIA BAICALENSIS) root extract, 2 to 4 parts of Hamamelis Virginiana (HAMAMELIS VIRGINIANA) extract, 0.5 to 0.8 part of ethylhexylglycerin, 0.4 to 0.7 part of Sophora flavescens root (SOROAANGUSTIFOLIA) root extract, 0.2 to 0.5 part of bisabolol, 0.4 to 0.6 part of ergothionein, 0.3 to 0.8 part of 1, 0.2.4 to 0.0.5 part of salicylic acid acetate, 0.1.0.0.0.0.1 to 0.5 part of salicylic acid, 0.0.1 to 0.05 part of citric acid, 0.0.1 to 0.1.8 parts of FOLIPEAK oil, 0.05 to 0.0.0.0.0.1 part of FOLIPA, 0.8 parts of FOLIP-0.0.0.0.0.0.0.0.1 part of FOLIP-1-2-1-2-1-ethyl-1-2-1-2-ethyl-1-2-1-2-1-2-1-2-ethyl-2-1-2-1-ethyl-1-2-ethyl-1-2-D-2-D, The balance being water. Wherein the water is deionized water or distilled water.
According to the scheme, propylene glycol, butanediol, ethylhexyl palmitate, cetearyl alcohol, cetearyl glucoside, glyceryl stearate, PEG-100 stearate and PEG-20 methyl glucose sesquistearate are used as oil phase substrates, so that the moisturizing cream has good moisturizing effect, and is economical and cheap in raw materials and free of toxic and side effects; the acne-removing and freckle-removing composition is matched with the Hamamelis virginiana, the glycyrrhiza inflate root extract and the scutellaria baicalensis root extract, can improve the local estrogen level of the cortex, can enhance the metabolism of skin cells, has the effects of resisting oxidation, ageing and inflammation, preventing allergy, relaxing and astringing, can maintain the elasticity and wrinkle of the skin, and has good water holding capacity; and finally, the skin conditioning agents such as ethyl hexyl glycerol, the extract of the roots of the sophora flavescens, bisabolol, ergothioneine, 1, 2-hexanediol, tocopheryl acetate, salicylic acid, xanthan gum, disodium EDTA, cajeput oil, hexamidine dihydrochloride and the like are matched to enhance the effects of moisturizing, anti-allergy, antioxidation, restoration, whitening, acne resistance, acne removal and the like of the product.
Preferably, the preservative is one or more of p-hydroxyacetophenone, phenoxyethanol, chlorpyrifos, methylparaben and propylparaben. Further, the preservative comprises 0.2-0.3 of p-hydroxyacetophenone, 0.2-0.3 of phenoxyethanol, 0.05-0.08 of chlorpyrifos, 0.2-0.4 of methyl hydroxybenzoate and 0.1-0.3 of propyl hydroxybenzoate.
Preferably, the pH regulator adopts EDTA disodium.
Preferably, the color agent also comprises 0.001-0.002 of color agent, wherein the color agent adopts CI19140 (lemon yellow).
Preferably, the acne cream comprises the following components: propylene glycol 5, ethylhexyl palmitate 3, cetearyl alcohol 2, cetearyl glucoside 2, glyceryl stearate 0.5, PEG-100 stearate 0.5, PEG-20 methylglucamine sesquistearate 0.6, butylene glycol 0.5, glycyrrhiza inflate extract 0.1, scutellaria baicalensis root extract 0.2, Hamamelis virginiana extract 2, ethylhexylglycerol 0.5, radix Sophorae Flavescentis extract 0.5, bisabolol 0.3, ergothioneine 0.5, 1, 2-hexanediol 0.5, p-hydroxyacetophenone 0.4, tocopheryl acetate 0.2, phenoxyethanol 0.2, chlorphenesin 0.05, methylparaben 0.2, propylhydroxybenzoate 0.1, salicylic acid 0.1, xanthan gum 0.2, EDTA disodium 0.05, hexidine dihydrochloride 0.1, melaleuca pentandra 0.1, CI191400.001, and the balance water.
The invention also discloses a preparation method of the acne-removing cream, which comprises the following steps:
s1, accurately weighing various raw materials in a formula, and placing the raw materials in a clean and sterilized utensil;
s2, uniformly dispersing the disodium EDTA with the propylene glycol, adding the hexamidine dihydrochloride, stirring and dissolving, and heating to 80-83 ℃;
s3, adding the ethylhexyl palmitate, the cetearyl alcohol, the cetearyl glucoside, the glyceryl stearate, the PEG-100 stearate, the PEG-20 methyl glucose sesquistearate, the ethyl hexyl glycerol, the bisabolol, the p-hydroxyacetophenone, the tocopheryl acetate, the phenoxyethanol, the chlorpyrifos, the methylparaben, the propylhydroxybenzoate, the xanthan gum and the cajeput oil into an oil phase pot, mixing and heating to 80-83 ℃, uniformly stirring and completely dissolving the materials, and keeping the temperature for 5-7 minutes;
s4, pumping the material prepared in the step S3 into an emulsifying pot, vacuumizing, stirring and homogenizing at the rotating speed of 2700RPM for 6-10 minutes, and then stirring and cooling to 48 ℃; adding the glycyrrhiza inflate extract, the scutellaria baicalensis root extract, the hamamelis virginiana extract, the sophora flavescens root extract, the ergothioneine, the 1, 2-hexanediol and the aqueous solution prepared in the step S2, continuously vacuumizing, stirring and homogenizing at 2700RPM for 4-6 minutes, and preserving heat for 6-10 minutes;
s5, adding the salicylic acid and CI19140 into the system, carrying out vacuum homogenization for 3 minutes at the rotating speed of 2700RPM, then continuing stirring and cooling to 35-38 ℃, discharging, and standing to normal temperature.
Compared with the prior art, the invention has the following beneficial effects: the components of the acne cream are mild in formula, free of stimulation, synergistic, good in skin permeability, capable of quickly and effectively moistening skin, and capable of resisting inflammation, removing acne, calming, resisting allergy, preserving moisture and locking water and the like.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
In order to better illustrate the present disclosure, several preferred embodiments are described below. However, these specific examples are only for illustrating the present invention and are not intended to limit the present invention.
An acne-removing cream containing hamamelis virginiana components is prepared from the following components in percentage by weight: 4 to 8 parts of propylene glycol, 2 to 5 parts of ethylhexyl palmitate, 1 to 4 parts of cetearyl alcohol, 1 to 3 parts of cetearyl glucoside, 0.5 to 1 part of glyceryl stearate, 0.25 to 0.75 part of PEG-100 stearate, 0.6 to 1 part of PEG-20 methyl glucose sesquistearate, 0.4 to 0.8 part of butylene glycol, 0.1 to 0.3 part of licorice root (IGCYRRHIZA INFLATA) root extract, 0.2 to 0.5 part of Scutellaria BAICALENSIS (SCUTELLARIA BAICALENSIS) root extract, 2 to 4 parts of Hamamelis Virginiana (HAMAMELIS VIRGINIANA) extract, 0.5 to 0.8 part of ethylhexylglycerin, 0.4 to 0.7 part of Sophora flavescens root (SOROAANGUSTIFOLIA) root extract, 0.2 to 0.5 part of bisabolol, 0.4 to 0.6 part of ergothionein, 0.3 to 0.8 part of 1, 0.2.4 to 0.0.5 part of salicylic acid acetate, 0.1.0.0.0.0.1 to 0.5 part of salicylic acid, 0.0.1 to 0.05 part of citric acid, 0.0.1 to 0.1.8 parts of FOLIPEAK oil, 0.05 to 0.0.0.0.0.1 part of FOLIPA, 0.8 parts of FOLIP-0.0.0.0.0.0.0.0.1 part of FOLIP-1-2-1-2-1-ethyl-1-2-1-2-ethyl-1-2-1-2-1-2-1-2-ethyl-2-1-2-1-ethyl-1-2-ethyl-1-2-D-2-D, The balance being water. Wherein the water is deionized water or distilled water.
Preferably, the preservative is one or more of p-hydroxyacetophenone, phenoxyethanol, chlorpyrifos, methylparaben and propylparaben. Further, the preservative comprises 0.2-0.3 of p-hydroxyacetophenone, 0.2-0.3 of phenoxyethanol, 0.05-0.08 of chlorpyrifos, 0.2-0.4 of methyl hydroxybenzoate and 0.1-0.3 of propyl hydroxybenzoate.
Preferably, the pH regulator adopts EDTA disodium.
Preferably, the color agent also comprises 0.001-0.002 of color agent, wherein the color agent adopts CI19140 (lemon yellow).
According to the scheme, propylene glycol, butanediol, ethylhexyl palmitate, cetearyl alcohol, cetearyl glucoside, glyceryl stearate, PEG-100 stearate and PEG-20 methyl glucose sesquistearate are used as oil phase substrates, so that the moisturizing cream has good moisturizing effect, and is economical and cheap in raw materials and free of toxic and side effects; the acne-removing and freckle-removing composition is matched with the Hamamelis virginiana, the glycyrrhiza inflate root extract and the scutellaria baicalensis root extract, can improve the local estrogen level of the cortex, can enhance the metabolism of skin cells, has the effects of resisting oxidation, ageing and inflammation, preventing allergy, relaxing and astringing, can maintain the elasticity and wrinkle of the skin, and has good water holding capacity; and finally, the skin conditioning agents such as ethyl hexyl glycerol, the extract of the roots of the sophora flavescens, bisabolol, ergothioneine, 1, 2-hexanediol, tocopheryl acetate, salicylic acid, xanthan gum, disodium EDTA, cajeput oil, hexamidine dihydrochloride and the like are matched to enhance the effects of moisturizing, anti-allergy, antioxidation, restoration, whitening, acne resistance, acne removal and the like of the product.
The invention also discloses a preparation method of the acne-removing cream, which comprises the following steps:
s1, accurately weighing various raw materials in a formula, and placing the raw materials in a clean and sterilized utensil;
s2, uniformly dispersing the disodium EDTA with the propylene glycol, adding the hexamidine dihydrochloride, stirring and dissolving, and heating to 80-83 ℃;
s3, adding the ethylhexyl palmitate, the cetearyl alcohol, the cetearyl glucoside, the glyceryl stearate, the PEG-100 stearate, the PEG-20 methyl glucose sesquistearate, the ethyl hexyl glycerol, the bisabolol, the p-hydroxyacetophenone, the tocopheryl acetate, the phenoxyethanol, the chlorpyrifos, the methylparaben, the propylhydroxybenzoate, the xanthan gum and the cajeput oil into an oil phase pot, mixing and heating to 80-83 ℃, uniformly stirring and completely dissolving the materials, and keeping the temperature for 5-7 minutes;
s4, pumping the material prepared in the step S3 into an emulsifying pot, vacuumizing, stirring and homogenizing at the rotating speed of 2700RPM for 6-10 minutes, and then stirring and cooling to 48 ℃; adding the glycyrrhiza inflate extract, the scutellaria baicalensis root extract, the hamamelis virginiana extract, the sophora flavescens root extract, the ergothioneine, the 1, 2-hexanediol and the aqueous solution prepared in the step S2, continuously vacuumizing, stirring and homogenizing at 2700RPM for 4-6 minutes, and preserving heat for 6-10 minutes;
s5, adding the salicylic acid and the CI19140 into the system, carrying out vacuum homogenization for 3 minutes at the rotating speed of 2700RPM, then continuing stirring and cooling to 35-38 ℃, discharging, and standing to normal temperature.
Example 1
The preparation method comprises the following steps:
s1, accurately weighing various raw materials in a formula, and placing the raw materials in a clean and sterilized utensil;
s2, uniformly dispersing the disodium EDTA with the propylene glycol, adding the hexamidine dihydrochloride, stirring and dissolving, and heating to 80-83 ℃;
s3, adding the ethylhexyl palmitate, the cetearyl alcohol, the cetearyl glucoside, the glyceryl stearate, the PEG-100 stearate, the PEG-20 methyl glucose sesquistearate, the ethyl hexyl glycerol, the bisabolol, the p-hydroxyacetophenone, the tocopheryl acetate, the phenoxyethanol, the chlorpyrifos, the methylparaben, the propylhydroxybenzoate, the xanthan gum and the cajeput oil into an oil phase pot, mixing and heating to 80-83 ℃, uniformly stirring and completely dissolving the materials, and keeping the temperature for 5-7 minutes;
s4, pumping the material prepared in the step S3 into an emulsifying pot, vacuumizing, stirring and homogenizing at the rotating speed of 2700RPM for 6-10 minutes, and then stirring and cooling to 48 ℃; adding the glycyrrhiza inflate extract, the scutellaria baicalensis root extract, the hamamelis virginiana extract, the sophora flavescens root extract, the ergothioneine, the 1, 2-hexanediol and the aqueous solution prepared in the step S2, continuously vacuumizing, stirring and homogenizing at 2700RPM for 4-6 minutes, and preserving heat for 6-10 minutes;
s5, adding the salicylic acid and the CI19140 into the system, carrying out vacuum homogenization for 3 minutes at the rotating speed of 2700RPM, then continuing stirring and cooling to 35-38 ℃, discharging, and standing to normal temperature.
Example 2
The preparation method is similar to example 1.
Safety and efficacy evaluation test
The safety and efficacy of the acne cream of the invention are evaluated as follows:
the safety test method of the acne-removing cream comprises the following steps: 30 test subjects were selected to perform the spot test on the acne cream products of example 1 and example 2, and the skin reaction was observed after 24 hours by visual observation:
through the patch test, the test subjects of the above example 1 and example 2 have no adverse reaction.
The efficacy test of the acne-removing cream is to detect and evaluate the effect of the acne-removing cream on propionibacterium acnes through an inhibition test, namely, the propionibacterium acnes is put into a culture medium containing the acne-removing cream products of the above example 1 and example 2, then the growth and the reproduction of the propionibacterium acnes are observed,
the test results show that the acne-removing and freckle-removing composition prepared from the witch hazel, the glycyrrhiza inflata root extract and the scutellaria baicalensis root extract has good anti-inflammatory and acne-removing effects.
It is to be noted that the sources of the raw materials and reagents used in the present invention are commercially available, and the experimental method of the present invention, in which the specific conditions are not specified, is generally carried out according to the conventional conditions or the conditions recommended by the manufacturers.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents and are included in the scope of the present invention.
Claims (9)
1. An acne-removing cream containing hamamelis virginiana components is characterized by being prepared from the following components in percentage by weight:
4-8 parts of propylene glycol, 2-5 parts of ethylhexyl palmitate, 1-4 parts of cetearyl alcohol, 1-3 parts of cetearyl glucoside, 0.5-1 part of glyceryl stearate, 0.25-0.75 part of PEG-100 stearate, 0.6-1 part of PEG-20 methyl glucose sesquistearate, 0.4-0.8 part of butanediol, 0.1-0.3 part of liquorice root extract, 0.2-0.5 part of scutellaria root extract, 2-4 parts of witch hazel extract, 0.5-0.8 part of ethyl hexyl glycerol, 0.4-0.7 part of sophora flavescens root extract, 0.2-0.5 part of bisabolol, 0.4-0.6 part of ergothioneine, 0.3-0.8 part of 1, 2-hexanediol, 0.2-0.4 part of tocopherol acetate, 0.1-0.2 part of salicylic acid, 0.2-0.5 part of xanthan gum, 0.05-0.1 part of pH regulator, 0.1 part of cajeput oil, 0.1-0.38 parts of chlorhexidine dihydrochloride and the balance of preservative.
2. The acne-removing cream containing hamamelis virginiana components according to claim 1, wherein the acne-removing cream comprises the following components in percentage by weight: the antiseptic is one or more of p-hydroxyacetophenone, phenoxyethanol, chlorpyrifos, methyl hydroxybenzoate and propyl hydroxybenzoate.
3. The acne cream containing hamamelis virginiana components according to claim 1 or 2, wherein the acne cream comprises the following components in percentage by weight: the preservative comprises 0.2-0.3 of p-hydroxyacetophenone, 0.2-0.3 of phenoxyethanol, 0.05-0.08 of chlorobenzene myzus cumini, 0.2-0.4 of methyl hydroxybenzoate and 0.1-0.3 of propyl hydroxybenzoate.
4. The acne-removing cream containing hamamelis virginiana components according to claim 1, wherein the acne-removing cream comprises the following components in percentage by weight: the pH regulator adopts EDTA disodium.
5. The acne-removing cream containing hamamelis virginiana components according to claim 1, wherein the acne-removing cream comprises the following components in percentage by weight: also comprises 0.001-0.002 of colorant.
6. The acne-removing cream containing hamamelis virginiana components according to claim 5, wherein the acne-removing cream comprises the following components in percentage by weight: the colorant was CI 19140.
7. The acne cream containing hamamelis virginiana ingredients in claim 1, which is prepared from the following components in percentage by weight: propylene glycol 5, ethylhexyl palmitate 3, cetearyl alcohol 2, cetearyl glucoside 2, glyceryl stearate 0.5, PEG-100 stearate 0.5, PEG-20 methylglucamine sesquistearate 0.6, butylene glycol 0.5, glycyrrhiza inflate extract 0.1, scutellaria baicalensis root extract 0.2, Hamamelis virginiana extract 2, ethylhexylglycerol 0.5, radix Sophorae Flavescentis extract 0.5, bisabolol 0.3, ergothioneine 0.5, 1, 2-hexanediol 0.5, p-hydroxyacetophenone 0.4, tocopheryl acetate 0.2, phenoxyethanol 0.2, chlorphenesin 0.05, methylparaben 0.2, propylhydroxybenzoate 0.1, salicylic acid 0.1, xanthan gum 0.2, EDTA disodium 0.05, hexidine dihydrochloride 0.1, melaleuca pentandra 0.1, CI191400.001, and the balance water.
8. The anti-acne cream containing hamamelis virginiana components according to claim 1 or 7, wherein the water is deionized water or distilled water.
9. The preparation method of the acne cream containing the hamamelis virginiana component according to any one of claims 1 to 7, wherein the steps are as follows:
s1, accurately weighing various raw materials in a formula, and placing the raw materials in a clean and sterilized utensil;
s2, uniformly dispersing the disodium EDTA with the propylene glycol, adding the hexamidine dihydrochloride, stirring for dissolving, and heating to 80-83 ℃;
s3, adding the ethylhexyl palmitate, the cetearyl alcohol, the cetearyl glucoside, the glyceryl stearate, the PEG-100 stearate, the PEG-20 methyl glucose sesquistearate, the ethylhexyl glycerol, the bisabolol, the p-hydroxyacetophenone, the tocopherol acetate, the phenoxyethanol, the chlorpyrifos, the methylparaben, the propylparaben, the xanthan gum and the cajeput oil into an oil phase pot, mixing and heating to 80-83 ℃, uniformly stirring and completely dissolving the mixture, and keeping the temperature for 5-7 minutes;
s4, pumping the material prepared in the step S3 into an emulsifying pot, vacuumizing, stirring and homogenizing at 2700RPM for 6-10 minutes, and then stirring and cooling to 48 ℃; adding the glycyrrhiza inflate root extract, the scutellaria baicalensis root extract, the witch hazel extract, the sophora flavescens root extract, the ergothioneine, the 1, 2-hexanediol and the aqueous solution prepared in the step S2, continuously vacuumizing, stirring and homogenizing at 2700RPM for 4-6 minutes, and preserving heat for 6-10 minutes;
s5, adding the salicylic acid and the CI19140 into the system, carrying out vacuum homogenization for 3 minutes at the rotating speed of 2700RPM, then continuing stirring and cooling to 35-38 ℃, discharging, and standing to normal temperature.
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| CN116509782A (en) * | 2023-05-11 | 2023-08-01 | 百肽德医药生物科技(广东)有限公司 | Acne-removing factor and cosmetics thereof |
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