CN114392393A - Subcutaneous injection composition for skin self-repair and use method thereof - Google Patents
Subcutaneous injection composition for skin self-repair and use method thereof Download PDFInfo
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- CN114392393A CN114392393A CN202111551932.1A CN202111551932A CN114392393A CN 114392393 A CN114392393 A CN 114392393A CN 202111551932 A CN202111551932 A CN 202111551932A CN 114392393 A CN114392393 A CN 114392393A
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- 238000010254 subcutaneous injection Methods 0.000 title claims abstract description 27
- 239000007929 subcutaneous injection Substances 0.000 title claims abstract description 27
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- 239000011550 stock solution Substances 0.000 claims abstract description 64
- 238000002347 injection Methods 0.000 claims abstract description 55
- 239000007924 injection Substances 0.000 claims abstract description 55
- 238000002156 mixing Methods 0.000 claims abstract description 35
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
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Images
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
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- Animal Behavior & Ethology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a subcutaneous injection composition for skin self-repair and a use method thereof, and the subcutaneous injection composition specifically comprises the following operation steps: s1: injection tissue preconfiguration, S2: purifying stock solution, S3: injection tissue mixing, S4: negative pressure exhaust, S5: the present invention replaces the conventional collagen macromolecules with oligopeptide stock solution of amino acid peptide chain micromolecules, so that the amino acid peptide chain is easy to absorb, and the present invention is different from other peptides in that the collagen peptide chain can be directly absorbed without being digested by a human body. Oligopeptides can be further divided into: oligopeptide-1, oligopeptide-3, oligopeptide-5, etc., oligopeptide-6 is also called hexapeptide or hexapeptide, and has rapid absorption. Compared with the human body, the absorption of macromolecular protein is faster by 129600 seconds, and faster by 64800 seconds, wherein the dermal layer is used for positioning by punctiform injection, so that the process of uniform absorption of the skin can be effectively increased, and the degree of protection of the skin is more uniform.
Description
Technical Field
The invention belongs to the technical field of cosmetology, and particularly relates to a subcutaneous injection composition for skin self-repair and a using method thereof.
Background
Beauty is a life style, and the desire for beauty varies more and more. Although the aesthetic looks of people are constantly changing, the pursuit of beauty is not always changed, thereby creating the beauty industry. Ever since the existence of human beings, there has been beauty treatment. The beauty treatment is to beautify the appearance of people. With the development of society and the improvement of science and technology, the beauty treatment is continuously changed and improved from content to form. In the cosmetic field, anti-aging is one of its most important components. When people age, the change of appearance is reflected in the aspect of face, and there are three main manifestations: wrinkles, prolapse, collapse. That is, the skin of people is aged loose with age, so that it is necessary to beautify, maintain and repair the skin of the face in order to make the face less afraid of aging. For example, the patent application number is CN202111010494.8, the cosmetic injection with anti-aging function and the preparation method thereof relate to the technical field of medical cosmetology, and the cosmetic injection with anti-aging function comprises the following components in parts by weight: 18-25 parts of physiological saline, 19-29 parts of collagen, 23-32 parts of hyaluronic acid, 7-11 parts of poly-L-lactic acid, 5-6 parts of glutathione, 2-3 parts of mannitol and 1-3 parts of vitamin. The invention has the filling effect by adding collagen and hyaluronic acid, and can effectively solve the problem of short-time insufficient secretion of body fluid by adding physiological saline; the polylactic acid mainly has the functions of stimulating an organism to independently generate collagen, activating various enzymes by matching with glutathione, promoting the metabolism of sugar, fat and protein, improving the osmotic pressure of blood plasma by mannitol, improving the activity of cells by vitamins, stimulating the cells to absorb the injection from multiple aspects, and solving the problems that the injection position bulges and the cosmetic effect is poor due to the phenomena of aggregation, uneven absorption and poor absorption effect easily caused by the cosmetic injection in the prior art.
When the technical scheme is used, the molecular diameter of the collagen is too large, so that the collagen is not easy to be directly absorbed by skin, the acting course is long, and a lot of nutrient substances are dissipated.
Disclosure of Invention
The present invention is directed to a subcutaneous injection composition for skin self-healing and a method of using the same, which solves the above-mentioned problems of the background art.
In order to achieve the purpose, the invention provides the following technical scheme: a subcutaneous injection composition for skin self-repair specifically comprises the following operation steps:
s1: injecting a tissue preconfiguration, the injecting the tissue comprising: oligopeptide stock solution, lactobionic acid stock solution, normal saline and vitamin E, wherein the normal saline is prepared by deionized water;
s2: purifying the stock solution, namely circularly concentrating and purifying the oligopeptide stock solution and the lactobionic acid stock solution by a countercurrent falling film concentration evaporator until the concentration volume reaches 80 percent of the original volume, dissolving vitamin E powder in physiological saline, and evaporating and purifying at the temperature of 150-200 ℃ to prepare the vitamin E into viscous stock solution;
s3: mixing the injection tissue, mixing oligopeptide stock solution and lactobionic acid stock solution with physiological saline as base solution, mixing at 70-80 deg.C, irradiating with ultraviolet, adding vitamin E, and mixing;
s4: negative pressure exhaust, namely removing bubbles generated in the mixing process of the stock solution by using the stock solution after the mixing is finished through the negative pressure which is 10-15KPa lower than the standard atmospheric pressure, and maintaining the pressure for 15-18 minutes;
s5: sterilizing and packaging, raising the temperature to 120 ℃ again after mixing, continuing for 1-2 minutes, and evaporating part of the normal saline.
Preferably, the mass part ratio of the raw materials in the step S1 is as follows: 10-15 parts of oligopeptide stock solution, 7-9 parts of lactobionic acid stock solution, 6-9 parts of normal saline and 2-3 parts of vitamin E.
Also disclosed is a method of using a subcutaneous injection composition for skin self-healing, the method comprising:
(a) disinfecting the face with a disinfectant;
(b) local anesthesia is performed on the face by anesthetic;
(c) injecting an injection compounded by injection tissue substances into a skin fascia layer by using an injector for soft stripping, and simultaneously performing point injection positioning on a dermis layer of a single part, wherein the injection amount is determined by the saturation of the skin state;
(d) after the fascia layer is stripped, lattice supplementary injection is carried out to complete the dot injection fixation;
(e) irradiating with red light, coating the skin surface with the infusion solution after injection, and irradiating with medical infrared far light for accelerating absorption;
(f) ice compress for sedation, and then adopt medical relieving mask for repairing and moisturizing;
(g) according to the repairing condition, secondary operation can be carried out after a period of time, and the effect is enhanced.
Preferably, the topical anesthesia in step b is performed by local subcutaneous injection.
Preferably, the syringe used in step c is of small gauge, 1-1.5 ml.
Preferably, the needle caliber of the syringe in the step c is 0.4-0.5 mm.
Preferably, the injection dosage of the dermis layer in the step c is 0.07-0.12 mg.
Preferably, the secondary operation in step g may be performed at intervals of 30 to 45 days.
The invention has the technical effects and advantages that:
the present invention replaces the conventional collagen macromolecules with oligopeptide stock solution of amino acid peptide chain micromolecules, so that the amino acid peptide chain is easy to absorb, and the present invention is different from other peptides in that the collagen peptide chain can be directly absorbed without being digested in a human body. Oligopeptides can be further divided into: oligopeptide-1, oligopeptide-3, oligopeptide-5, etc., oligopeptide-6 is also called hexapeptide or hexapeptide, and has rapid absorption. Compared with the human body, the absorption of macromolecular protein is faster by 129600 seconds, and faster by 64800 seconds, wherein the dermal layer is used for positioning by punctiform injection, so that the process of uniform absorption of the skin can be effectively increased, and the degree of protection of the skin is more uniform.
Drawings
FIG. 1 is a schematic view of the process of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A subcutaneous injection composition for skin self-repair specifically comprises the following operation steps:
s1: injecting a tissue preconfiguration, the injecting the tissue comprising: oligopeptide stock solution, lactobionic acid stock solution, normal saline and vitamin E, wherein the normal saline is prepared by deionized water;
s2: purifying the stock solution, namely circularly concentrating and purifying the oligopeptide stock solution and the lactobionic acid stock solution by a counter-current falling film concentration evaporator until the concentration volume reaches 80 percent of the original volume, dissolving vitamin E powder in physiological saline, and evaporating and purifying at the temperature of 150 ℃ to prepare the vitamin E into viscous stock solution;
s3: mixing the injection tissue, mixing oligopeptide stock solution and lactobionic acid stock solution with physiological saline as base solution, mixing at 70-80 deg.C, irradiating with ultraviolet, adding vitamin E, and mixing;
s4: negative pressure exhaust, namely removing bubbles generated in the mixing process of the stock solution by using the stock solution after the mixing is finished through negative pressure lower than the standard atmospheric pressure of 10KPa, and maintaining the pressure for 15 minutes;
s5: sterilizing, packaging, heating to 100 deg.C again after mixing, maintaining for 1 min, and evaporating part of physiological saline.
Preferably, the mass part ratio of the raw materials in the step S1 is as follows: 10 parts of oligopeptide stock solution, 7 parts of lactobionic acid stock solution, 6 parts of normal saline and 2 parts of vitamin E.
Also disclosed is a method of using a subcutaneous injection composition for skin self-healing, the method comprising:
(a) disinfecting the face with a disinfectant;
(b) c, local anesthesia is carried out on the face by anesthetic, and local subcutaneous injection is adopted for the epidermal anesthesia in the step b;
(c) injecting an injection compounded by injection tissue substances into a skin fascia layer by using an injector to perform soft stripping, and simultaneously performing point injection positioning on a dermis layer of a single part, wherein the injection amount is determined by the saturation of the skin state, the injector in the step c adopts a small size of 1ml, the caliber of a needle head of the injector in the step c is 0.4mm, and the injection dose of the dermis layer in the step c is 0.07 mg;
(d) after the fascia layer is stripped, lattice supplementary injection is carried out to complete the dot injection fixation;
(e) irradiating with red light, coating the skin surface with the infusion solution after injection, and irradiating with medical infrared far light for accelerating absorption;
(f) ice compress for sedation, and then adopt medical relieving mask for repairing and moisturizing;
(g) and g, according to the repairing condition, secondary operation can be performed after a period of time, the effect is enhanced, and the secondary operation can be performed at an interval of 30 days in the step g.
Example 2
A subcutaneous injection composition for skin self-repair specifically comprises the following operation steps:
s1: injecting a tissue preconfiguration, the injecting the tissue comprising: oligopeptide stock solution, lactobionic acid stock solution, normal saline and vitamin E, wherein the normal saline is prepared by deionized water;
s2: purifying the stock solution, namely circularly concentrating and purifying the oligopeptide stock solution and the lactobionic acid stock solution by a counter-current falling film concentration evaporator until the concentration volume reaches 80 percent of the original volume, dissolving vitamin E powder in physiological saline, and evaporating and purifying at the temperature of 200 ℃ to prepare the vitamin E into viscous stock solution;
s3: mixing the injection tissue, mixing oligopeptide stock solution and lactobionic acid stock solution at 80 deg.C with normal saline as base solution, irradiating with ultraviolet, adding vitamin E, and mixing;
s4: negative pressure exhaust, namely removing bubbles generated in the mixing process of the stock solution by using the stock solution after the mixing is finished through negative pressure lower than the standard atmospheric pressure of 15KPa, and maintaining the pressure for 18 minutes;
s5: sterilizing, packaging, heating to 120 deg.C again after mixing, maintaining for 2 min, and evaporating part of physiological saline.
Preferably, the mass part ratio of the raw materials in the step S1 is as follows: 15 parts of oligopeptide stock solution, 9 parts of lactobionic acid stock solution, 9 parts of normal saline and 3 parts of vitamin E.
Also disclosed is a method of using a subcutaneous injection composition for skin self-healing, the method comprising:
(a) disinfecting the face with a disinfectant;
(b) c, local anesthesia is carried out on the face by anesthetic, and local subcutaneous injection is adopted for the epidermal anesthesia in the step b;
(c) injecting an injection compounded by injection tissue substances into a skin fascia layer by using an injector to perform soft stripping, and simultaneously performing point injection positioning on a dermis layer of a single part, wherein the injection amount is determined by the saturation of the skin state, the injector in the step c adopts a small size of 1.5ml, the caliber of a needle head of the injector in the step c is 0.5mm, and the injection amount of the dermis layer in the step c is 0.12 mg;
(d) after the fascia layer is stripped, lattice supplementary injection is carried out to complete the dot injection fixation;
(e) irradiating with red light, coating the skin surface with the infusion solution after injection, and irradiating with medical infrared far light for accelerating absorption;
(f) ice compress for sedation, and then adopt medical relieving mask for repairing and moisturizing;
(g) and g, according to the repairing condition, secondary operation can be performed after a period of time, the effect is enhanced, and the secondary operation can be performed at an interval of 45 days in the step g.
Example 3
A subcutaneous injection composition for skin self-repair specifically comprises the following operation steps:
s1: injecting a tissue preconfiguration, the injecting the tissue comprising: oligopeptide stock solution, lactobionic acid stock solution, normal saline and vitamin E, wherein the normal saline is prepared by deionized water;
s2: purifying the stock solution, namely circularly concentrating and purifying the oligopeptide stock solution and the lactobionic acid stock solution by a counter-current falling film concentration evaporator until the concentration volume reaches 80 percent of the original volume, dissolving vitamin E powder in physiological saline, and evaporating and purifying at the temperature of 170 ℃ to prepare the vitamin E into viscous stock solution;
s3: mixing the injection tissue, mixing oligopeptide stock solution and lactobionic acid stock solution with physiological saline as base solution, mixing at 70-80 deg.C, irradiating with ultraviolet, adding vitamin E, and mixing;
s4: negative pressure exhaust, namely removing bubbles generated in the mixing process of the stock solution by using the stock solution after the completion of mixing through negative pressure lower than a standard atmospheric pressure of 14KPa, and maintaining the pressure for 16 minutes;
s5: sterilizing, packaging, heating to 110 deg.C again after mixing, and evaporating part of physiological saline for 1 min.
Preferably, the mass part ratio of the raw materials in the step S1 is as follows: oligopeptide stock solution 12 parts, lactobionic acid stock solution 8 parts, normal saline 7 parts and vitamin E3 parts.
Also disclosed is a method of using a subcutaneous injection composition for skin self-healing, the method comprising:
(a) disinfecting the face with a disinfectant;
(b) c, local anesthesia is carried out on the face by anesthetic, and local subcutaneous injection is adopted for the epidermal anesthesia in the step b;
(c) injecting an injection compounded by injection tissue substances into a skin fascia layer by using an injector to perform soft stripping, and simultaneously performing point injection positioning on a dermis layer of a single part, wherein the injection amount is determined by the saturation of the skin state, the injector in the step c adopts a small size of 1.4ml, the caliber of a needle head of the injector in the step c is 0.45mm, and the injection amount of the dermis layer in the step c is 0.10 mg;
(d) after the fascia layer is stripped, lattice supplementary injection is carried out to complete the dot injection fixation;
(e) irradiating with red light, coating the skin surface with the infusion solution after injection, and irradiating with medical infrared far light for accelerating absorption;
(f) ice compress for sedation, and then adopt medical relieving mask for repairing and moisturizing;
(g) and d, according to the repairing condition, secondary operation can be carried out after a period of time, the effect is enhanced, and the secondary operation can be carried out at 32 days in the step g.
The present invention replaces the conventional collagen macromolecules with oligopeptide stock solution of amino acid peptide chain micromolecules, so that the amino acid peptide chain is easy to absorb, and the present invention is different from other peptides in that the collagen peptide chain can be directly absorbed without being digested in a human body. Oligopeptides can be further divided into: oligopeptide-1, oligopeptide-3, oligopeptide-5, etc., oligopeptide-6 is also called hexapeptide or hexapeptide, and has rapid absorption. Compared with the human body, the absorption of macromolecular protein is faster by 129600 seconds, and faster by 64800 seconds, wherein the dermal layer is used for positioning by punctiform injection, so that the process of uniform absorption of the skin can be effectively increased, and the degree of protection of the skin is more uniform.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (8)
1. A subcutaneous injection composition for skin self-healing, characterized by: the method specifically comprises the following operation steps:
s1: injecting a tissue preconfiguration, the injecting the tissue comprising: oligopeptide stock solution, lactobionic acid stock solution, normal saline and vitamin E, wherein the normal saline is prepared by deionized water;
s2: purifying the stock solution, namely circularly concentrating and purifying the oligopeptide stock solution and the lactobionic acid stock solution by a countercurrent falling film concentration evaporator until the concentration volume reaches 80 percent of the original volume, dissolving vitamin E powder in physiological saline, and evaporating and purifying at the temperature of 150-200 ℃ to prepare the vitamin E into viscous stock solution;
s3: mixing the injection tissue, mixing oligopeptide stock solution and lactobionic acid stock solution with physiological saline as base solution, mixing at 70-80 deg.C, irradiating with ultraviolet, adding vitamin E, and mixing;
s4: negative pressure exhaust, namely removing bubbles generated in the mixing process of the stock solution by using the stock solution after the mixing is finished through the negative pressure which is 10-15KPa lower than the standard atmospheric pressure, and maintaining the pressure for 15-18 minutes;
s5: sterilizing and packaging, raising the temperature to 120 ℃ again after mixing, continuing for 1-2 minutes, and evaporating part of the normal saline.
2. A subcutaneous injection composition for skin self-repair according to claim 1, wherein: the raw materials in the step S1 have the following mass part ratio: 10-15 parts of oligopeptide stock solution, 7-9 parts of lactobionic acid stock solution, 6-9 parts of normal saline and 2-3 parts of vitamin E.
3. A method of using a subcutaneous injection composition for skin self-healing as claimed in any of claims 1-2, wherein: the method comprises the following steps:
(a) disinfecting the face with a disinfectant;
(b) local anesthesia is performed on the face by anesthetic;
(c) injecting an injection compounded by injection tissue substances into a skin fascia layer by using an injector for soft stripping, and simultaneously performing point injection positioning on a dermis layer of a single part, wherein the injection amount is determined by the saturation of the skin state;
(d) after the fascia layer is stripped, lattice supplementary injection is carried out to complete the dot injection fixation;
(e) irradiating with red light, coating the skin surface with the infusion solution after injection, and irradiating with medical infrared far light for accelerating absorption;
(f) ice compress for sedation, and then adopt medical relieving mask for repairing and moisturizing;
(g) according to the repairing condition, secondary operation can be carried out after a period of time, and the effect is enhanced.
4. The method of using a subcutaneous injection composition for skin self-healing according to claim 3, wherein: the epidermal anesthesia in step b is performed by local subcutaneous injection.
5. The method of using a subcutaneous injection composition for skin self-healing according to claim 3, wherein: the injector in the step c adopts a small size of 1-1.5 ml.
6. The method of using a subcutaneous injection composition for skin self-healing according to claim 3, wherein: the caliber of the syringe needle in the step c is 0.4-0.5 mm.
7. The method of using a subcutaneous injection composition for skin self-healing according to claim 3, wherein: the injection dosage of the dermis layer in the step c is 0.07-0.12 mg.
8. The method of using a subcutaneous injection composition for skin self-healing according to claim 3, wherein: the secondary operation in step g can be carried out at intervals of 30-45 days.
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