CN114392000B - Laboratory mouse temporomandibular joint positioning device - Google Patents

Abstract

The utility model provides a laboratory mouse temporomandibular joint positioner, includes the working plate, is provided with mounting and support column on the working plate, connects ear hole setting element on the support column, and ear hole setting element is used for inserting laboratory mouse's external auditory canal and joint to laboratory mouse's ear hole, is provided with the connecting strip on the ear hole setting element, is connected with the buckle that is used for joint to laboratory mouse's zygomatic arch root on the connecting strip. The invention can position the position of the ear hole by using the ear hole positioning piece, is favorable for quickly positioning the zygomatic arch and the zygomatic arch root of the experimental rat, can simultaneously fix the relative positions of the zygomatic bone and the skin by using the buckle, ensures that two points, namely the auditory canal and the zygomatic bone, outside the whole device are fixed, further realizes the projection of important osseous dissection points on the surface of the experimental rat body, indirectly positions the osseous marking points on the body surface, ensures that the positions during operation and injection do not obviously move along with the displacement of the skin, has accurate positioning of the joint cavity and high repeatability, and obviously improves the reliability and the experimental efficiency of experimental results.

Description

Experimental rat temporomandibular joint positioning device

technical field

The invention relates to the field of experimental rat test equipment, in particular to an experimental rat temporomandibular joint positioning device.

Background technique

The temporomandibular joint is the most complex joint in the human body, including the articular surface of the temporal bone, the articular disc, the condyle, the joint capsule, and the joint ligaments. The temporomandibular joint is linked left and right to support jaw movements such as chewing, swallowing, language and some expressions. Compared to other joints in the body, the temporomandibular joint has different morphological, functional, biomechanical, and biological properties, and bears only a limited load-bearing capacity.

Temporomandibular disorder syndrome (TMD) is the most common disease in the oral and maxillofacial region. The main clinical manifestations are pain in the joint area, joint snapping during exercise, and mandibular movement disorder, but the pathogenesis is not fully understood.

The experimental mouse is an animal model for the study of TMD, which helps researchers to have a deeper understanding of the pathogenesis, pathogenic factors, disease progression process of TMD and find effective treatment measures, so as to improve the treatment effect, slow down the disease progression and protect joint function.

At present, the temporomandibular joint cavity surgery or temporomandibular joint cavity injection is mainly performed on the experimental mice by fixing the experimental mice on the experimental table. However, because the anatomical tissue of the temporomandibular joint is more delicate and smaller than other joints, it is difficult to locate by directly touching the important bony anatomical structures, and the temporomandibular joint of the experimental mouse is wrapped by a joint capsule composed of fibrous tissue and synovial lining. Therefore, the animal skin will be significantly displaced during injection, and the traditional method of drawing markers on the body surface is also inaccurate. Inaccurate positioning can easily damage the important blood vessels of the experimental mice, resulting in damage to the articular cartilage itself, irritating the surrounding tissues and causing other joint diseases. Moreover, the temporomandibular joint disorder syndrome is mostly a chronic disease, and the injection cycle in animal models is generally longer. Variable control is difficult, and ineffective or even wrong injection treatments lead to poor sample uniformity and unreliable experimental results.

SUMMARY OF THE INVENTION

The object of the present invention is to provide a device for locating the temporomandibular joint of an experimental mouse, so as to solve the problem of injury to the experimental mouse, joint pathological changes caused by difficulty in accurately locating the temporomandibular joint of the experimental mouse in the prior art, as well as unreliable experimental results and low experimental efficiency. question.

The present invention is achieved through the following technical solutions:

An experimental rat temporomandibular joint positioning device, comprising an ear hole positioning member, the ear hole positioning member is used for inserting into the external auditory canal of the experimental mouse and being clamped to the ear hole of the experimental mouse, the ear hole positioning member is provided with a connecting strip, and the connection The strip is attached with a clip for clipping to the root of the zygomatic arch of the experimental mouse.

In this technical solution, the size of the lower end of the ear hole positioning member matches the size of the external auditory canal of the experimental mouse, and is used for inserting into the external auditory canal of the experimental mouse and snapping at the position of the bony ear canal of the experimental mouse during the operation.

A connecting bar is set on the ear hole positioning column. Since the length of the connecting bar is certain, after the ear hole positioning piece is inserted into the ear hole, the staff can quickly find the approximate position of the zygomatic arch through the connecting bar, and use the connecting bar and its connecting rods. The clip locates the base of the zygomatic arch and secures it.

After the experimental mouse is anesthetized, the limbs and head of the experimental mouse can be fixed on the work board with the fixing parts, and the ear hole of the experimental mouse is facing upward. After positioning the bony ear hole of the experimental mouse to the position of the zygomatic arch through a metal or rubber connecting strip, use the buckle to find the position of the root of the zygomatic arch and fix it. It affects the sight of surgery and injection. At the same time, the connecting strips attached to the root of the zygomatic arch and the clamping point of the buckle can be positioned to show the course of the rear half of the zygomatic arch, expand the positioning range and improve the accuracy of positioning. The joint cavity is located at the root of the zygomatic arch connected by the buckle and the connecting strip, the ear hole positioned by the ear hole positioning piece, and the palpable concave area between the condyles, thereby realizing fast and accurate joint cavity positioning.

In this technical solution, the ear hole positioning piece can be used to locate the position of the ear hole, which is beneficial to quickly locate the zygomatic arch and the root of the zygomatic arch of the experimental mouse, and the relative position of the zygomatic bone and the skin can be fixed at the same time by using the buckle, so as to ensure the external auditory canal and zygomatic bone of the whole device. These two points are fixed, so as to project important bony anatomical points on the body surface of the experimental mouse, indirectly locate the bony marker points on the body surface, and ensure that the position during surgery and injection does not move significantly with the displacement of the skin , the joint cavity positioning is accurate and the repeatability is high, which significantly improves the reliability of the experimental results and the experimental efficiency, and can perform a variety of invasive operations on the joint.

As a preferred embodiment of the present invention, a guide ring handle is provided on the ear hole positioning member, an injection guide ring is connected to the guide ring handle, and the bottom of the injection guide ring is used to be embedded in the joint cavity of the experimental rat .

In this technical solution, on the basis of the ear hole positioning member, the buckle and the connecting strip, the positioning device further includes an injection guide ring. Specifically, the guide ring handle of the injection guide ring is arranged on the guide ring handle. In some embodiments, the guide ring handle can move back and forth, up and down relative to the injection guide ring to adjust the relative positions of the injection guide ring and the ear hole positioning member. The injection guide ring is a ring structure, the bottom of which can be embedded into the joint cavity of the experimental mouse. In one or more embodiments, the bottom end of the injection guide ring extends downwardly and beyond the guide ring shank, forming a raised portion. After the position of the ear hole positioning member and the buckle is fixed, the position of the concave joint cavity can be easily and quickly determined by using the bottom of the injection guide ring, and the bottom of the injection guide ring can be directly embedded into the joint cavity to form a fixed point, so as to combine the positioning of the ear hole There are three fixed points in total, including the ear hole, the root of the zygomatic arch, and the joint cavity, which not only significantly improves the stability of positioning, but also effectively improves the accuracy of positioning, especially for the accurate injection of temporomandibular joint cavity. The experimental efficiency and the reliability of the experimental results are further improved, the operation difficulty is reduced, and the pain of the experimental mice is alleviated.

As a preferred structure of the injection guide ring in the present invention, a rubber ring is sleeved at the bottom of the injection guide ring, and the diameter of the rubber ring gradually increases from top to bottom. In this technical solution, the bottom of the injection guide ring is sleeved with a rubber ring, and the rubber ring replaces the bottom of the injection guide ring to clamp the joint cavity, which can not only prevent the bottom of the injection guide ring from scratching the experimental mouse, but also can use the elasticity of the rubber itself to better It fits with the joint cavity, improves the stability of fixation, and can increase the size range of the joint cavity that the injection guide ring can stably snap to a certain extent, and is suitable for experimental mice with different joint cavity sizes. Further, in this technical solution, the diameter of the rubber ring is set to gradually increase from top to bottom, so that the outer wall of the rubber ring has an annular protrusion. After the rubber ring is finally snapped into the joint cavity, the condyle, the root of the zygomatic arch and the ear canal will be able to squeeze the protrusion, thereby effectively increasing the The stability of the positioning of the injection guide ring in the joint cavity.

As another preferred structure of the injection guide ring in the present invention, the injection guide ring includes a first half ring and a second half ring, and an airway is arranged in the first half ring and/or the second half ring, so The air passage is communicated with a jet hole, an inflatable piece is arranged between the first half ring and the second half ring, the inflatable piece is connected with the air passage and the inflatable hole, and the inflatable piece can be expanded when the external air enters through the inflatable hole , and push the first half ring and the second half ring to move back.

In this technical solution, the injection guide ring includes two semi-circular rings, one of which is provided with an air passage and an air injection hole, or both semi-circular rings are provided with an air passage and an air injection hole. The air passage and the air injection hole are communicated with the interior of the inflatable piece connecting the first half ring and the second half ring, and the inflatable piece is provided with an inflatable hole, so that the air flow of the external air source can pass through the inflatable hole, the inflatable piece, the gas in turn. The inflatable part can be inflated to a certain extent when the air flow passes through, so as to push apart the first half ring and the second half ring, so that the size of the injection guide ring increases, thereby promoting the injection The outer wall of the guide ring fits and abuts against the side wall of the joint cavity, so as to improve the stability of positioning.

When in use, the injection guide ring is put into the joint cavity after the ear hole positioning member and the buckle are positioned. The initial size of the injection guide ring can be set small enough to meet the size of the joint cavity of small mice. After the injection guide ring is put in, the inflatable hole is connected to an external air source, such as a steel cylinder. After being decompressed by the pressure reducing valve, the gas continues to enter the inflatable part through the inflatable hole, and the inflatable part expands to push the first half ring and the second half ring. Moving back, the size of the injection guide ring increases and is firmly snapped into the joint cavity; at the same time, the gas continues to pass through the airway and the air injection hole, and finally exits the injection guide ring. After the operation is completed, the gas source valve is closed, When the inflatable member is not filled with gas, the first half ring and the second half ring move toward each other under the pressing action of the joint cavity, and the size of the injection guide ring is reduced so that it can be taken out from the joint cavity. The above-mentioned structure can effectively increase the scope of the object of use of the injection guide ring, and can stably locate the joint cavity of rats and mice.

Further, the air injection holes are located inside the first half ring and/or the second half ring. By arranging the air injection holes on the inner side of the first half ring and the second half ring, after the air is ejected through the air injection holes, the surface of the joint cavity inside the injection guide ring can be blown, so as to continuously clean the area and reduce the impact of hair on the field of vision. Occlusion, better field of vision for joint cavity surgery and injection.

Further, an airway is provided in the first half ring or the second half ring. Preferably, only setting the air channel in the first half ring or the second half ring can further simplify the structure of the injection guide ring, and at the same time, the purpose of increasing the size of the injection guide ring and stably connecting it under the action of the air flow can be achieved; When the air flow in the hole is purging, it will be purged from the first half ring to the second half ring, or the second half ring to the first half ring, and the direction of the purging is controllable, so that the staff can adjust the direction of the purging according to the needs. At the same time, when the first half ring and the second half ring are purged at the same time, the airflow convection in the injection guide ring causes the airflow disorder inside the injection guide ring, and even interferes with the operation or injection.

Further, the injection guide ring can be moved relative to the ear hole locator and fixed to a desired position on the ear hole locator. Specifically, the ear hole positioning member is provided with a third sliding groove, the guide ring handle can move in the third sliding groove, the third sliding groove is communicated with a third locking groove, and the third locking groove A third locking piece is arranged in the tightening groove, and the third locking piece is used to fix the position of the guide ring handle in the third sliding groove. The guide ring handle can move in the up and down, front and rear directions in the chute of the ear hole positioning member, and after the positioning of the ear hole positioning member, the bottom of the injection guide ring can be quickly embedded into the joint cavity, and the third locking Through the third locking groove into the third chute, the guide ring handle is clamped in the third chute, so as to realize the fixed connection between the injection guide ring and the ear hole positioning piece, and improve the positioning efficiency and accuracy .

Further, it also includes a base on which a work plate is hingedly connected, and a support column for connecting the ear hole positioning member and a fixing member for fixing the experimental mouse are provided on the work plate, and a sleeve is provided on the base. The sleeve is internally threaded with a jacking column, and the top end of the jacking column is slidably arranged in the jacking chute provided on the bottom surface of the working plate.

In the technical solution, the working board is a platform for fixing the experimental mice and performing surgery and injection. In order to fix the experimental mouse, a fixing piece is arranged on the working board, and the fixing piece can be fixed by using the rubber band, belt and ring of the prior art. The working plate is also provided with a support column, and the support column is directly or indirectly connected with an ear hole positioning piece. The working plate can be turned relative to the base around the hinged end, so as to realize the adjustment of the angle of the working plate to meet the needs of surgery and injection. The jacking mechanism provided on the base includes a sleeve and a jacking column that can rotate relative to the sleeve, the jacking column and the sleeve are connected by threads, and the top of the jacking column is located in the jacking chute on the bottom surface of the working plate . When adjusting the working plate angle, only need to rotate the jacking column clockwise or counterclockwise, then the jacking column can be screwed out or screwed into the sleeve, so as to adjust the total length of the sleeve and the jacking column, and realize the adjustment of the working plate angle. And, the threaded lifting column and the sleeve can realize the fine adjustment of the angle to meet the precision requirements of surgery and injection.

Further, the support column is provided with a cantilever, the cantilever is provided with a collar for being sleeved on the support column, the collar is threadedly connected with a first locking member, and the first lock The fastener is used to fix the position of the collar on the support column. The cantilever set on the support column can be rotated relative to the support column by using the collar, and after rotating to the required position, the collar can be fixed on the support column by the first locking piece, thereby facilitating the fixing of the experimental mouse to the workbench After installation, after rotating and adjusting the position of the cantilever, the relative position of the cantilever and the support column is fixed to improve the flexibility of the positioning device.

Further, the ear hole positioning member can move relative to the cantilever and be fixed at a desired position on the cantilever. Specifically, the cantilever is provided with a second chute, the ear hole positioning member can move in the second chute, the second chute communicates with a second locking groove, and the second locking groove A second locking piece is arranged inside, and the second locking piece is used to fix the position of the ear hole positioning piece in the second sliding groove. The ear hole positioning member can move in the up and down, front and rear directions in the second chute of the cantilever, and after the relative position of the cantilever and the support column is fixed, the positioning ball at the bottom end of the ear hole positioning member can be quickly extended into the external auditory canal. After the positioning ball is fixed, use the second locking piece to enter the second chute through the second locking slot, and clamp the ear hole positioning piece in the second chute, so as to realize the fixation between the ear hole positioning piece and the cantilever. connection to further improve positioning efficiency and accuracy.

Compared with the prior art, the present invention has the following advantages and beneficial effects:

1. The present invention can locate the position of the ear hole by using the ear hole positioning piece, which is beneficial to quickly locate the zygomatic arch and the root of the zygomatic arch of the experimental mouse, and can fix the relative position of the zygomatic bone and the skin at the same time by using the buckle and the connecting strip, so as to ensure that the external auditory canal and The two points of the zygomatic bone are fixed, so as to realize the projection of important bony anatomical points on the body surface of the experimental mouse, and indirectly locate the bony marker points on the body surface, and ensure that the position during surgery and injection is not caused by skin displacement. Significant movement, accurate joint cavity positioning and high repeatability, significantly improve the reliability of experimental results and experimental efficiency, and can perform a variety of invasive surgeries on joints;

2. In the present invention, after the position of the ear hole positioning member and the buckle is fixed, the position of the concave joint cavity can be conveniently and quickly determined by using the bottom of the injection guide ring, and the bottom of the injection guide ring can be directly embedded into the joint cavity to form a fixed point, Therefore, combined with the ear hole positioning piece and the buckle to form three fixed points, the ear hole, the root of the zygomatic arch, and the joint cavity, which not only significantly improves the stability of positioning, but also effectively improves the accuracy of positioning, which is especially beneficial to the temporomandibular joint cavity. Accurate injection, further improving the experimental efficiency and reliability of experimental results, while reducing the difficulty of operation and reducing the pain of experimental mice;

3. In the present invention, the diameter of the rubber ring is set to a structure that gradually increases from top to bottom, so that the outer wall of the rubber ring has an annular protrusion. After the rubber ring is finally snapped into the joint cavity, the condyles, the root of the zygomatic arch and the ear canal will be able to squeeze the bulge, thereby effectively improving the injection guide. the stability of the positioning of the ring in the joint cavity;

4. In the present invention, the injection guide ring formed by the inflatable member and the two semicircular rings can effectively increase the scope of the use object of the injection guide ring, and can stably locate the joint cavity of rats and mice. The ejected gas can purge the inside of the injection guide ring in a directional way, continuously clean the area and reduce the occlusion of the vision by the hair, and the vision of joint cavity surgery and injection is better;

5. The relative positions of the support column, the cantilever, the ear hole positioning member and the guide ring handle of the present invention can be adjusted, which is beneficial to improve the flexibility of the device, and can further improve the efficiency and accuracy of positioning.

Description of drawings

The accompanying drawings described herein are used to provide further understanding of the embodiments of the present invention, and constitute a part of the present application, and do not constitute limitations to the embodiments of the present invention. In the attached image:

Fig. 1 is a schematic diagram of the anatomical structure of an experimental mouse;

2 is a schematic structural diagram of a positioning device in a specific embodiment of the present invention;

3 is a schematic top view of a positioning device in a specific embodiment of the present invention;

4 is a schematic diagram of a connection structure between a support column and a cantilever in a specific embodiment of the present invention;

5 is a schematic diagram of the connection structure of the ear hole positioning member and the guide ring handle in the specific embodiment of the present invention;

6 is a schematic structural diagram of an injection guide ring of a structure in a specific embodiment of the present invention;

7 is a schematic structural diagram of an injection guide ring of another structure in a specific embodiment of the present invention;

8 is a schematic structural diagram of a jacking mechanism in a specific embodiment of the present invention;

FIG. 9 is a schematic diagram of locating the temporomandibular joint cavity of an experimental rat in a specific embodiment of the present invention.

The marks in the attached drawings and the corresponding parts names:

1-base, 2-work plate, 3-support column, 31-first locking piece, 4-cantilever, 41-collar, 42-second chute, 43-second locking piece, 44-second Locking groove, 5-ear hole positioning piece, 51-third locking groove, 52-third locking piece, 53-third sliding groove, 6-injection guide ring, 61-guide ring handle, 62-rubber ring, 63-first half ring, 64-second half ring, 65-inflatable piece, 66-inflatable hole, 67-airway, 68-air injection hole, 69-protrusion, 7-positioning ball, 8-connecting strip, 9- Buckle, 10- Fixing piece, 11- Sleeve, 12- Lifting column, 13- Lifting chute, 14- Fixing hole;

21- ear hole, 22- condyle, 23- root of zygomatic arch, 24- joint cavity.

Detailed ways

In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments and the accompanying drawings. as a limitation of the present invention.

In the description of the present invention, it should be understood that the terms "front", "rear", "left", "right", "upper", "lower", "vertical", "horizontal", "high", The orientation or positional relationship indicated by "low", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying the indicated device. Or elements must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as limiting the scope of protection of the present invention.

Example 1:

The experimental rat temporomandibular joint positioning device as shown in FIG. 2 to FIG. 5 includes a working board 2, on which a fixing member 10 for fixing the experimental rat is provided, and a supporting column 3 is provided on the working board 2 , the support column 3 is connected to the ear hole positioning member 5, the ear hole positioning member 5 is used for inserting the external auditory canal of the experimental mouse and clipped to the ear hole 21 of the experimental mouse, and the ear hole positioning member 5 is provided with a connecting strip 8, so The connecting bar 8 is connected with a clip 9 for clipping to the root 23 of the zygomatic arch of the experimental mouse.

In this embodiment, the operation difficulty can be reduced by combining with the work board, which is suitable for beginners. When the workload is heavy or the operation needs to be completed quickly by skilled hands, the ear hole positioning member 5, the connecting strip 8 and the buckle 9 can be directly used. After positioning the ear hole, the injection or operation can be completed by snapping the buckle to the root of the zygomatic arch.

In one or more embodiments, as shown in FIG. 3 , a plurality of fixing holes 14 are provided on the working plate, and the fixing members 10 bypassing the limbs of the experimental rat can be connected through the fixing holes 14, thereby realizing the experimental Any position of the table can be fixed according to the size of the experimental mouse, which improves the universality of the positioning device and can adjust the tightness of the fixation. In some embodiments, as shown in FIG. 3 , the fixing member includes a limb fixing member and a head fixing member, so that during the operation and injection process, the head of the experimental mouse is turned to one side, so that the side of the head is The joint cavity is facing upwards, which is convenient for observation and operation.

In one or more embodiments, the lower end of the ear hole positioning member is provided with a positioning ball 7, and the positioning ball is preferably made of medical rubber material, so as to prevent the ear hole positioning member from damaging the deep tissue of the external auditory canal during the process of inserting the ear hole positioning member. , the rubber has a certain deformation ability, can better fit to the inner wall of the ear hole through its own deformation, and improve the positioning stability of the ear hole positioning member.

In one or more embodiments, the connecting strip adopts metal wire or rubber strip with higher hardness, preferably, the connecting strip adopts rubber strip, so as to better fit in the process of locating the position of the root of the zygomatic arch In the vicinity of the joint cavity, avoid affecting the field of vision for surgery and injection. Not only that, but more importantly, as shown in Figure 9, the zygomatic arch is an arched bony structure consisting of the temporal process of the zygomatic bone and the zygomatic process of the temporal bone. The junction of the two is the root of the zygomatic arch, and the lower part is the The position of the joint cavity, the buckle can fix and locate a point on the zygomatic arch, for example, a certain point at the root of the zygomatic arch, and the connecting strip with certain deformability can be attached to the lower part of the zygomatic arch, and then the buckle can be used. Positioning this complete bony structure directly shows the course of the posterior half of the zygomatic arch on the body surface, allowing the needle and knife to be performed directly below the line of the connecting strip, which effectively improves the positioning efficiency and Accuracy; and, for more delicate procedures, which usually require openings, punctures or injections in different positions of the joint cavity, such as only the anterior or posterior parts, the use of deformable connecting strips to attach the zygomatic arch can directly confirm this site The contour range is further improved, and the accuracy of the operation for different parts of the joint cavity is further improved.

In one or more embodiments, the connecting bar is detachably connected to the ear hole positioning post, so that the connecting bar can be replaced after stress fatigue or damage. In one or more embodiments, the buckle can be any existing fixing clip that does not damage the epidermis of the experimental mouse.

After the experimental mouse is anesthetized, the limbs and head of the experimental mouse can be fixed on the work board with the fixing parts, and the ear hole of the experimental mouse is facing upward. After positioning the bony ear hole of the experimental mouse to the position of the zygomatic arch with a metal or rubber connecting strip, use the buckle to find the position of the root of the zygomatic arch and fix it, and then adjust the position of the connecting strip so that it is attached to the root of the zygomatic arch to assist in positioning And to avoid affecting the sight of surgery and injection, after the adjustment, the joint cavity is located at the root of the zygomatic arch connected by the buckle and the connecting strip, the ear hole positioned by the ear hole positioning piece, and the palpable concave area between the condyles, so as to achieve rapid, Accurate joint cavity positioning.

In this embodiment, the ear hole positioning piece can be used to locate the position of the ear hole, which is beneficial to quickly locate the zygomatic arch and the root of the zygomatic arch of the experimental mouse, and the relative positions of the zygomatic bone and the skin can be fixed at the same time by using the buckle, so as to ensure that the external auditory canal and the zygomatic bone of the whole device are both located. By fixing each point, the important bony anatomical points can be projected on the body surface of the experimental mouse, and the bony marker points can be positioned on the body surface indirectly, and the position during surgery and injection will not be significantly moved with the displacement of the skin. The positioning is accurate and the repeatability is high, which significantly improves the reliability of the experimental results and the experimental efficiency.

The two-point positioning method in this embodiment is more suitable for joint cavity surgery, and can provide a wider field of vision.

Example 2:

On the basis of Embodiment 1, as shown in FIGS. 2 to 5 , the ear hole positioning member 5 is provided with a third chute 53 , and the guide ring handle 61 can move in the third chute 53 , so The third chute 53 communicates with a third locking groove 51 , and a third locking member 52 is arranged in the third locking groove 51 , and the third locking member 52 is used to fix the guide ring handle 61 The position in the third chute 53; the support column 3 is provided with a cantilever 4, and the cantilever 4 is provided with a collar 41 for being sleeved on the support column 3, the collar 41 The upper thread is connected with a first locking piece 31, and the first locking piece (31) is used to fix the position of the collar 41 on the support column 3; the cantilever 4 is provided with a second chute 42, The ear hole positioning member 5 can move in the second sliding slot 42, the second sliding slot 42 is communicated with a second locking groove 44, and a second locking member 43 is arranged in the second locking groove 44 , the second locking member 43 is used to fix the position of the ear hole positioning member 5 in the second sliding groove 42 .

During use, adjust the angle of the cantilever relative to the support column according to the deviation of the head of the experimental mouse, and then adjust the position of the ear hole positioning member on the cantilever to ensure that the ear hole positioning member is stably positioned in the ear hole. Next, adjust the buckle After the position of the injection guide ring is snapped into the joint cavity, and the position of the guide ring handle relative to the ear hole positioning member is fixed.

In this embodiment, the relative positions of the support column, the cantilever, the ear hole positioning member, and the guide ring handle can be adjusted, which is beneficial to improve the flexibility of the device and further improve the efficiency and accuracy of positioning.

In some embodiments, as shown in FIG. 2 and FIG. 8 , it further includes a base 1 , the work board 2 is hingedly connected to the base 1 , and a sleeve 11 is provided on the base 1 , and the sleeve 11 A jacking column 12 is connected with the internal thread, and the top end of the jacking column 12 is slidably arranged in the jacking chute 13 provided on the bottom surface of the working plate 2 . When adjusting the working plate angle, only need to rotate the jacking column clockwise or counterclockwise, then the jacking column can be screwed out or screwed into the sleeve, so as to adjust the total length of the sleeve and the jacking column, and realize the adjustment of the working plate angle. .

Example 3:

On the basis of the above embodiment, the ear hole positioning member 5 is provided with a guide ring handle 61, the guide ring handle 61 is connected with an injection guide ring 6, and the bottom of the injection guide ring 6 is used for embedding the experiment In the joint cavity 24 of the rat.

In one or more embodiments, the bottom end of the injection guide ring extends downwardly and beyond the guide ring shank, forming a boss 69 .

In this embodiment, as shown in FIGS. 1 and 9 , after the positions of the ear hole positioning member 5 and the buckle 9 are fixed, the bottom of the injection guide ring 6 can conveniently and quickly determine the position of the concave joint cavity, that is, the condyle 22 , the area between the root of the zygomatic arch 23 and the ear hole 21, and the bottom of the injection guide ring 6 can be directly embedded into the joint cavity 24 to form a fixed point, so as to combine the ear hole positioning piece and the buckle to form the ear hole, the root of the zygomatic arch, and the joint cavity. The three fixed points not only significantly improve the stability of the positioning, but also effectively improve the accuracy of the positioning, especially for the accurate injection of the temporomandibular joint cavity, which further improves the experimental efficiency and the reliability of the experimental results, while reducing the It reduces the difficulty of operation and reduces the pain of experimental mice.

Example 4:

On the basis of the above embodiment, as shown in FIG. 6 , a rubber ring 62 is sleeved at the bottom of the injection guide ring 6 , and the diameter of the rubber ring 62 gradually increases from top to bottom. In this embodiment, the diameter of the rubber ring is set to gradually increase from top to bottom, so that the outer wall of the rubber ring has annular protrusions. During the clamping process of the injection guide ring, the protrusions on the outer wall of the rubber ring After the rubber ring is finally snapped into the joint cavity, the condyles, the root of the zygomatic arch and the ear canal will be able to squeeze the bulge, thereby effectively improving the injection guide. Stability of ring positioning in the joint cavity.

Example 5:

On the basis of the above embodiment, the injection guide ring 6 includes a first half ring 63 and a second half ring 64, and an air passage 67 is provided in the first half ring 63 and/or the second half ring 64, so The air passage 67 is communicated with an air injection hole 68, an inflatable member 65 is arranged between the first half ring 63 and the second half ring 64, the inflatable member 65 is connected with the air passage 67 and the inflatable hole 66, and the inflatable member 65 can The first half ring 63 and the second half ring 64 are pushed to move back when the external air flow enters through the inflation hole 66 and expands.

When in use, the injection guide ring is put into the joint cavity after the ear hole positioning member and the buckle are positioned. The initial size of the injection guide ring can be set small enough to meet the size of the joint cavity of small mice. After the injection guide ring is put in, the inflatable hole is connected to an external air source, such as a steel cylinder. After being decompressed by the pressure reducing valve, the gas continues to enter the inflatable part through the inflatable hole, and the inflatable part expands to push the first half ring and the second half ring. Moving back, the size of the injection guide ring increases and is firmly snapped into the joint cavity; at the same time, the gas continues to pass through the airway and the air injection hole, and finally exits the injection guide ring. After the operation is completed, the gas source valve is closed, When the inflatable member is not filled with gas, the first half ring and the second half ring move toward each other under the pressing action of the joint cavity, and the size of the injection guide ring is reduced so that it can be taken out from the joint cavity. The above-mentioned structure can effectively increase the scope of the object of use of the injection guide ring, and can stably locate the joint cavity of rats and mice.

In one or more embodiments, the air injection holes 68 are located inside the first half-ring 63 and/or the second half-ring 64 .

In some embodiments, an air channel 67 is provided in the first half ring 63 or the second half ring 64 to realize directional purging.

As used herein, "first," "second," "third," etc. (eg, first chute, second chute, third chute, first locking member, second locking member, first Three locking pieces, etc.) are only used to differentiate corresponding components for the sake of clarity of description, and are not intended to limit any order or emphasize importance or the like. In addition, the term "connected" used herein may be directly connected or indirectly connected via other components unless otherwise specified.

The specific embodiments described above further describe the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above descriptions are only specific embodiments of the present invention, and are not intended to limit the scope of the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims (9)

1. The experimental mouse temporomandibular joint positioning device is characterized by comprising an ear hole positioning piece (5), wherein the ear hole positioning piece (5) is used for being inserted into an external auditory canal of an experimental mouse and clamped to an ear hole (21) of the experimental mouse, a connecting strip (8) is arranged on the ear hole positioning piece (5), and a buckle (9) used for being clamped to a zygomatic arch root (23) of the experimental mouse is connected to the connecting strip (8); be provided with guide ring handle (61) on earhole setting element (5), be connected with injection guide ring (6) on guide ring handle (61), the bottom of injection guide ring (6) is arranged in imbedding in the joint chamber (24) of laboratory mouse.

2. The temporomandibular joint positioning device of claim 1, wherein a rubber ring (62) is sleeved on the bottom of the injection guide ring (6), and the diameter of the rubber ring (62) increases gradually from top to bottom.

3. The experimental rat temporomandibular joint positioning device according to claim 1, wherein the injection guide ring (6) comprises a first half ring (63) and a second half ring (64), an air passage (67) is provided in the first half ring (63) and/or the second half ring (64), the air passage (67) is communicated with an air injection hole (68), an inflation member (65) is provided between the first half ring (63) and the second half ring (64), the inflation member (65) is communicated with the air passage (67) and an inflation hole (66), and the inflation member (65) can expand when external air enters through the inflation hole (66) and push the first half ring (63) and the second half ring (64) to move back.

4. A laboratory mouse temporomandibular joint positioning device according to claim 3, wherein the air injection holes (68) are located on the inside of the first half ring (63) and/or the second half ring (64).

5. A laboratory mouse temporomandibular joint positioning device according to claim 3, wherein an airway (67) is provided in either the first half collar (63) or the second half collar (64).

6. The experimental rat temporomandibular joint positioning device according to any one of claims 1 to 5, characterized in that a third sliding slot (53) is provided on the ear hole positioning member (5), the guide ring handle (61) can move in the third sliding slot (53), the third sliding slot (53) is communicated with a third locking groove (51), a third locking member (52) is provided in the third locking groove (51), and the third locking member (52) is used for fixing the position of the guide ring handle (61) in the third sliding slot (53).

7. The experimental rat temporomandibular joint positioning device according to claim 6, further comprising a base (1), wherein the base (1) is hinged to a working plate (2), the working plate (2) is provided with a supporting pillar (3) for connecting with an ear hole positioning piece (5) and a fixing piece (10) for fixing the experimental rat, the base (1) is provided with a sleeve (11), the sleeve (11) is internally threaded with a jacking pillar (12), and the top end of the jacking pillar (12) is slidably arranged in a jacking sliding groove (13) arranged on the bottom surface of the working plate (2).

8. The temporomandibular joint positioning device for laboratory mice according to claim 7, characterized in that a cantilever (4) is arranged on the supporting column (3), a collar (41) for sleeving the supporting column (3) is arranged on the cantilever (4), a first locking member (31) is screwed on the collar (41), and the first locking member (31) is used for fixing the position of the collar (41) on the supporting column (3).

9. The temporomandibular joint positioning device of claim 8, wherein a second sliding slot (42) is provided on the cantilever (4), the ear hole positioning element (5) is movable in the second sliding slot (42), the second sliding slot (42) is connected with a second locking slot (44), a second locking element (43) is provided in the second locking slot (44), and the second locking element (43) is used for fixing the position of the ear hole positioning element (5) in the second sliding slot (42).

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