CN114376625A - Biopsy data visualization system and biopsy device - Google Patents

Abstract

The present application relates to a biopsy data visualization system and a biopsy device, the biopsy data visualization system comprising a computer control system, and: a tissue marker for marking a lesion location; the radiography system is used for radiography of the focus tissues, acquiring focus position images and biopsy sampling image data in real time and sending the focus position images and the biopsy sampling image data to the computer control system; the temperature sensing system is used for acquiring the real-time temperature of the lesion tissue and/or the cutting sleeve and/or the cryogenic cooling adhesion probe and sending the real-time temperature to the computer control system; a display for receiving and displaying the lesion location image and biopsy sampling image data and real-time temperature data. Through the radiography and the temperature monitoring of the focus tissue, the action, the temperature parameter and the like in the biopsy process can be visually processed, so that a doctor can obtain effective data feedback, know the position of the focus tissue in real time and carry out the operation process of biopsy sampling on the focus, and the accuracy of low-temperature biopsy sampling is improved.

Description

Biopsy data visualization system and biopsy device

technical field

The present application relates to the technical field of data visualization, and in particular, to a biopsy data visualization system and a biopsy device.

Background technique

A biopsy, or biopsy, is an important tool for diagnosing a patient's cancerous mass, initial deterioration, and other diseases and disorders.

Among the existing biopsy techniques, the technique of sampling the lesion tissue by means of a low-temperature biopsy needle is relatively popular. Generally, an attached probe with liquid cryogen is used to perform rotary coring biopsy. For example, a patented technology with a publication number of CN100571649C provides a rotary core biopsy device with a liquid cryogen attached probe. The device includes a probe having a configuration that allows a surgeon to immobilize a suspicious mass or mass in focal tissue during a biopsy procedure; the probe is provided with a rigid tube and a sharpened tip; for securing the mass to the probe , the surgeon uses the tip to pierce the mass; compressed gas is passed through the coolant supply ductwork, delivering cool air into the biopsy instrument, and through the ductwork extending within the probe's rigid tube to direct the coolant to the tip to cool the tip , and then the mass was attached to the cooled probe; finally the mass-like core was obtained through the cutting cannula of the corer.

During the technical implementation process, the applicant found the following technical problems:

During the biopsy procedure, the probe is used to fix the suspicious mass or mass in the focal tissue, and in the stage of sampling the mass with the tip piercing, whether it is the physical data value and motion characteristics of the device, or There is no real-time monitoring and feedback on the pathological symptoms of the lesion tissue, so that no effective data feedback can be obtained during the sampling process. Therefore, in view of this situation, it is necessary to visualize it to facilitate the sampling process and improve the sampling accuracy.

SUMMARY OF THE INVENTION

In view of this, the present application proposes a biopsy data visualization system and a biopsy device, which have solved the technical defects of the above-mentioned published patents.

A first aspect of the present application proposes a biopsy data visualization system, including a computer control system, and further including:

Tissue markers to mark the location of lesions;

an imaging system, used for imaging the lesion tissue, acquiring the lesion position image and biopsy sampling image data in real time, and sending it to the computer control system;

a temperature sensing system for acquiring the real-time temperature of the lesion tissue and/or the cutting cannula and/or the cryogenically cooled attachment probe, and sending it to the computer control system;

a display for receiving and displaying the image of the lesion position, the image data of the biopsy sampling and the real-time temperature data;

The imaging system, the temperature sensing system and the display are respectively connected to the computer control system in communication.

As an optional embodiment of the present application, optionally, the material of the tissue marker is a material that is imaged under the exploration of the contrast system.

As an optional embodiment of the present application, optionally, the imaging system includes:

The image acquisition module is used for real-time acquisition and transmission of angiography images;

an image processing module, configured to receive the angiography image, and preprocess the angiography image through an image preprocessing algorithm to obtain a preprocessed angiography image; ;

The image storage module is used for receiving and storing the digital encrypted image, and sending the digital encrypted image to the computer control system through a digital encryption channel.

As an optional embodiment of the present application, optionally, the temperature sensing system includes:

A temperature detection chip, which is arranged on the lesion tissue and/or the cutting cannula and/or the cryogenically cooled attachment probe, and is used for corresponding acquisition and transmission of real-time temperature data;

The communication chip is electrically connected with the temperature detection chip, and is used for receiving the real-time temperature data and sending the real-time temperature data to the computer control system.

A second aspect of the present application provides a biopsy device, comprising a housing and a pneumatic system, wherein the pneumatic system is arranged in the housing, and further includes:

The above-mentioned biopsy data visualization system is used for real-time image angiography to guide biopsy sampling;

A cryogenically cooled attachment probe, used for moving to the position of the lesion with the assistance of the biopsy data visualization system, and performing cryogenic cooling and fixing of the lesion;

a cutting cannula for moving to the fixed lesion position and performing low-temperature biopsy sampling with the assistance of the biopsy data visualization system;

The cryogenic cooling attachment probe coaxially moves in the cutting sleeve and is driven by the pneumatic system.

As an optional embodiment of the present application, optionally, it also includes:

a delivery needle for delivering tissue markers in the biopsy data visualization system to the lesion tissue position with the assistance of the biopsy data visualization system; and, after the biopsy is completed, with the assistance of the biopsy data visualization system Next, the tissue markers in the biopsy data visualization system are removed from the lesion tissue location to the outside of the body surface.

As an optional embodiment of the present application, optionally, the material of the delivery needle or the needle tip portion of the delivery needle is a material that is visualized under the detection of the contrast system of the biopsy data visualization system.

As an optional embodiment of the present application, optionally, it also includes:

a biopsy tool, which is sealed and fitted in the installation cavity of the housing, and the cutting sleeve is sealed and fitted in the cutting sleeve;

a canister, which is fixed on the outer shell;

a compressed air tank, fitted in the tank;

The valve group is fixed on the casing, the input end is connected with the compressed air tank, and the output end is connected with the pneumatic system.

As an optional embodiment of the present application, optionally, it also includes:

a piercing pin connector, which is arranged at the channel between the canister and the valve group, and the gas outlet of the compressed air tank is fitted on the piercing pin connector;

When the compressed gas canister is fitted into the canister, the gas outlet of the compressed gas canister is pierced through the piercing pin connector to release the compressed gas into the valve group.

As an optional embodiment of the present application, optionally, the pneumatic system is a servo drive system, including a computer control system, a battery, a motor and a gear box, and the battery is electrically connected to the computer control system and the motor, respectively, and the The motor is connected to the gear box, and the output end is arranged on the gear box and keeps rotating at a constant speed.

Technical effects of this application:

This solution includes a computer control system, and: tissue markers for marking the position of the lesion; an imaging system for imaging the lesion tissue, acquiring image data of the lesion position and biopsy sampling in real time, and sending them to the computer control system; temperature; a sensing system for acquiring real-time temperature of the lesion tissue and/or cutting cannula and/or cryogenically cooled attachment probe and sending to the computer control system; a display for receiving and displaying the lesion location image and biopsy Sampling image data as well as real-time temperature data. Using tissue markers to locate the lesion, as well as imaging and temperature monitoring of the lesion tissue, the actions and temperature parameters of the biopsy process can be visualized, so that doctors can get effective data feedback, know the location of the lesion tissue in real time, and perform biopsy of the lesion. The sampling operation process improves the accuracy of cryogenic biopsy sampling.

Description of drawings

The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate exemplary embodiments, features and aspects of the application and together with the description, serve to explain the principles of the application.

Fig. 1 shows the composition schematic diagram of the biopsy data visualization system of the present application;

Fig. 2 shows the structural schematic diagram of the present application placed on the tissue marker;

FIG. 3 shows a schematic cross-sectional structure diagram of the biopsy needle of the present application.

Detailed ways

Various exemplary embodiments, features and aspects of the present application will be described in detail below with reference to the accompanying drawings. The same reference numbers in the figures denote elements that have the same or similar functions. While various aspects of the embodiments are shown in the drawings, the drawings are not necessarily drawn to scale unless otherwise indicated.

Among them, it should be understood that the terms "center", "portrait", "horizontal", "length", "width", "top", "bottom", "front", "rear", "left", "right" ", "Vertical", "Horizontal", "Top", "Bottom", "Inner", "Outer", "Clockwise", "Counterclockwise", "Axial", "Radial", "Circumferential" The orientation or positional relationship indicated by "" etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention or simplifying the description, rather than indicating or implying that the indicated device or element must have a specific orientation, a specific orientation, or a specific orientation. The orientation configuration and operation of the device should not be construed as a limitation of the present invention.

In addition, the terms "first" and "second" are only used for descriptive purposes, and should not be construed as indicating or implying relative importance or implying the number of indicated technical features. Thus, a feature defined as "first" or "second" may expressly or implicitly include one or more of that feature. In the description of the present invention, "plurality" means two or more, unless otherwise expressly and specifically defined.

The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration." Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.

In addition, in order to better illustrate the present application, numerous specific details are given in the following detailed description. It should be understood by those skilled in the art that the present application may be practiced without certain specific details. In some instances, methods, means, components and circuits well known to those skilled in the art have not been described in detail so as not to obscure the subject matter of the present application.

Example 1

This technology, by placing the lesion tissue on a tissue marker to locate the lesion, as well as imaging and temperature monitoring of the lesion tissue, can visualize the location of the lesion tissue, the action and temperature parameters of the biopsy process, etc., so that doctors can effectively Data feedback, real-time knowledge of the location of the lesion tissue and the operation process of biopsy sampling of the lesion, improve the accuracy of low temperature biopsy sampling.

As shown in FIG. 1 , the present application provides a biopsy data visualization system proposed in the first aspect of the present application, including a computer control system, and also includes:

The tissue marker is used to mark the location of the lesion; the tissue marker can be metal Ti, which is easily detected by the imaging system and facilitates imaging, thereby displaying the specific location of the lesion tissue. By placing a tissue marker, repositioning of the lesion during later treatment can be avoided, and with imaging systems such as ultrasound, magnetic resonance imaging (MRI) or x-ray, the location of the marker can be detected and a biopsy can be located. As shown in FIG. 2 , a cylindrical tissue marker 101 with a barb on its outer surface is placed in the lesion 103 through a delivery needle 102 . In this embodiment, the specific shape of the tissue marker is not limited here.

The imaging system is used for imaging the lesion tissue, acquires the lesion position image and biopsy sampling image data in real time, and sends it to the computer control system; the imaging system is mainly used for imaging the tissue markers of the lesion tissue, After the image is sent to the computer control system for processing, it is sent to the monitor for real-time display, so that the doctor can know the location of the lesion tissue in real time. In addition, the imaging system also performs imaging on the steps in multiple processes, and can perform real-time imaging on the rubbing of the delivery needle placed on the tissue marker, as well as the cutting cannula and probe of the biopsy. Therefore, correspondingly, the tip of the cutting cannula and the tip of the puncture segment to which the probe is attached need to be made of special materials that can be identified by angiography. In this embodiment, metal titanium is preferred. In this way, the imaging system can be used to perform imaging before and after the biopsy to realize the visualization of the biopsy operation, which is convenient for doctors to identify the location and perform accurate biopsy.

A temperature sensing system, used to acquire the real-time temperature of the lesion tissue and/or the cutting cannula and/or the cryogenically cooled attachment probe, and send it to the computer control system; in this embodiment, it is necessary to know the lesion tissue and biopsy needle in real time It is convenient to control the temperature environment required for a series of operations in the biopsy process. For example, the acquisition of the temperature of the lesion tissue can let the doctor know the pathological temperature of the lesion tissue, which is convenient to control the cooling time of the output cooling gas of the activation system, change the cooling time, etc.; The monitoring of temperature can facilitate the judgment of whether the temperature of the sampling facility for sampling the lesion tissue is appropriate, and avoid insufficient cooling temperature to affect cell activity. The temperature sensing system requires tiny temperature detection chip facilities or temperature sensing probes, etc., as long as it meets the temperature detection required for biopsy.

The display is used to receive and display the image of the lesion position, biopsy sampling image data and real-time temperature data; the impact data of the imaging system on the biopsy process is processed by the computer and sent to the display for display, so that the doctor can know the specific details of the biopsy process in real time. Information, accurate biopsy sampling of lesions.

The imaging system, the temperature sensing system and the display are respectively connected to the computer control system in communication.

As an optional embodiment of the present application, optionally, the material of the tissue marker is a material that is imaged under the exploration of the contrast system. In this embodiment, the tissue marker is preferably Ti.

As an optional embodiment of the present application, optionally, the imaging system includes:

The image acquisition module is used for real-time acquisition and transmission of angiography images;

an image processing module, configured to receive the angiography image, and preprocess the angiography image through an image preprocessing algorithm to obtain a preprocessed angiography image; ;

The image storage module is used for receiving and storing the digital encrypted image, and sending the digital encrypted image to the computer control system through a digital encryption channel.

In this embodiment, the imaging system is preferably an ultrasonic imaging system, and the image acquisition module is an image data acquisition facility of the ultrasonic imaging system, which can be an acquisition circuit composed of a piezoelectric transducer, an electronic circuit, and a processing chip. The processing algorithm preprocesses the angiography image to obtain the preprocessed angiography image; and performs digital image encryption on the preprocessed angiography image, and sends the image. The specific specifications and selection of piezoelectric transducers, electronic circuits, and processing chips are not limited here, and users can choose the combination according to their own needs. The interface of the processing chip is also not limited.

The image processing module, which can be replaced by image processing software, preprocesses the angiography image through an image preprocessing algorithm to obtain a preprocessed angiography image; and performs digital image encryption on the preprocessed angiography image, and sends the image; The storage module may use an electronic storage facility, which may be ROM or cloud storage, which is not limited here.

The medical image data is confidential data, therefore, the image digital encryption technology is used to process and save the processed image. When the terminal facility needs to call these image materials, it needs to be obtained through authority authentication and digital encryption and decryption. The method of authority authentication and decryption to obtain digital encrypted images will not be described in detail here.

As an optional embodiment of the present application, optionally, the temperature sensing system includes:

A temperature detection chip, which is arranged on the lesion tissue and/or the cutting cannula and/or the cryogenically cooled attachment probe, and is used for corresponding acquisition and transmission of real-time temperature data;

The communication chip is electrically connected with the temperature detection chip, and is used for receiving the real-time temperature data and sending the real-time temperature data to the computer control system.

In this embodiment, a temperature detection chip is installed on the tissue marker of the lesion tissue, the cutting end of the cutting cannula, and the end of the cryogenically cooled attachment probe, respectively, to obtain the respective working temperatures; at the same time, a communication chip is attached. The chip transmits the temperature data in real time. The specific choice of the communication chip is determined by the user, which is not limited here.

In this embodiment, if an ultrasonic imaging system is used, the supporting DICOM (Digital Imaging and Communication in Medicine) may be used for communication.

Each module or each step of the present invention can be implemented by a general-purpose computing device, and they can be centralized on a single computing device, or distributed on a network composed of multiple computing devices. Executed program code so that they can be stored in a storage device and executed by a computing device, or they can be fabricated separately into individual integrated circuit modules, or multiple modules or steps in them into a single integrated circuit module. to fulfill. As such, the present invention is not limited to any particular combination of hardware and software.

Therefore, the present invention locates the lesion through tissue markers, as well as angiographic imaging and temperature monitoring of the lesion tissue, so that the action and temperature parameters of the biopsy process can be visualized, so that the doctor can obtain effective data feedback and know the location of the lesion tissue and the temperature in real time. The operation process of biopsy sampling of lesions improves the accuracy of low temperature biopsy sampling.

Example 2

Based on the biopsy data visualization system of Embodiment 1, in this embodiment, the biopsy data visualization system is used in the biopsy in combination with the technology disclosed in Publication No. CN100571649C.

A second aspect of the present application proposes a biopsy device, which includes a housing 1 and a pneumatic system, wherein the pneumatic system is provided in the housing 1 .

As shown in Figure 3, in this embodiment, the biopsy device further includes:

The above-mentioned biopsy data visualization system is used for real-time image angiography to guide biopsy sampling;

A cryogenically cooled attachment probe, used for moving to the position of the lesion 103 with the assistance of the biopsy data visualization system, and performing cryogenic cooling and fixing of the lesion;

The cutting cannula 17 is used to move to the position of the fixed lesion 103 and perform low-temperature biopsy sampling with the assistance of the biopsy data visualization system;

The cryogenic cooling attachment probe coaxially moves in the cutting sleeve and is driven by the pneumatic system.

As an optional embodiment of the present application, optionally, it also includes:

The delivery needle 102 is used for delivering the tissue marker 101 in the biopsy data visualization system to the tissue position of the lesion 103 with the assistance of the biopsy data visualization system; and, after the biopsy is completed, in the biopsy data With the aid of the visualization system, the tissue markers in the biopsy data visualization system are removed from the lesion tissue location to the outside of the body surface. The specific type of delivery needle 102 is not limited here.

As an optional embodiment of the present application, optionally, the material of the delivery needle or the needle tip portion of the delivery needle is a material that is visualized under the detection of the contrast system of the biopsy data visualization system. Preferably it is Ti.

As an optional embodiment of the present application, optionally, it also includes:

The biopsy tool 16 is sealingly fitted in the installation cavity of the housing 1, and the cutting sleeve 17 is sealingly fitted within the biopsy tool 16;

The canister 5 is fixed on the casing;

The compressed air tank 18 is matched in the tank barrel 5;

The valve group 15 is fixed on the casing 1, its input end is connected to the compressed air tank 18, and its output end is connected to the pneumatic system.

As an optional embodiment of the present application, optionally, it also includes:

The piercing pin connector 4 is arranged at the channel between the canister and the valve group, and the gas outlet of the compressed air tank is fitted on the piercing pin connector;

When the compressed gas canister is fitted into the canister, the gas outlet of the compressed gas canister is pierced through the piercing pin connector to release the compressed gas into the valve group.

As shown in Figure 3, in this embodiment, the casing 1 is also provided with:

The intake end 10, located at the right end of the housing 1, communicates with the piston cylinder of the biopsy instrument 16 through a pipeline, and provides aerodynamic force for driving the movement of the attached probe; It is the movement force of the screw rod, so that the screw rod gas enters the piston cylinder through the intake end 10 and drives the screw rod to move. Through the air circulation, the reciprocating motion of the screw can be realized.

The air inlet is provided on the biopsy tool 16, and the cooling liquid output from the coolant supply pipeline system is guided into the attachment probe through the pipeline; a part of the cooling gas is distributed through the valve group for cooling the attachment probe , part of the pneumatic power used to cut the cannula distributed through the valve group, attach the probe and then enter the lesion 103 tissue for cooling sampling.

The valve 6 is arranged on the valve group 15, on which a first intake pipe 3 and a second intake pipe 7 are connected in parallel; wherein, the outlet end of the first intake pipe 3 is connected to the casing 1 and is attached to the The air inlet on the probe is connected to provide cooling gas for the attached probe; the second air inlet pipe 7 is connected to the air inlet end 10 to provide the pneumatic gas for the cutting sleeve; the outlet of the valve group 15 , the screw driven by a motor is opened and closed. After opening, the gas reaches the valve 6 through the gas pipe 8, and is distributed to the first intake pipe 3 and the second intake pipe 7, and then has their own gas circulation system for cooling and guiding, so The air outlet end of the first air inlet pipe 3 is connected to the housing 1 and communicated with the air inlet to provide cooling gas for the attached probe; the second air inlet pipe 7 is connected to the air inlet end 10 , providing the pneumatic gas for the attached probe. The air pipe 8 is connected between the valve group 15 and the valve 6 .

As an optional embodiment of the present application, optionally, the pneumatic system is a servo drive system, including a computer control system, a battery, a motor and a gear box, and the battery is electrically connected to the computer control system and the motor, respectively, and the The motor is connected to the gear box, and the output end is arranged on the gear box and keeps rotating at a constant speed.

For the specific structure of the pneumatic system and the supporting pneumatic facilities, please refer to the above-mentioned published patent, which will not be repeated here.

Using the biopsy data visualization system described in Example 1, the corresponding temperature sensor chips and communication chips are pre-processed and installed on the corresponding components of the biopsy device in Figure 3, and the imaging system and display are used to perform low-temperature biopsy sampling. That’s all it takes; during this period, the output and temperature of the cryogenic cooling gas can be adjusted according to the temperature data.

Various embodiments of the present application have been described above, and the foregoing descriptions are exemplary, not exhaustive, and not limiting of the disclosed embodiments. Numerous modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terminology used herein was chosen to best explain the principles of the various embodiments, the practical application or improvement over the technology in the marketplace, or to enable others of ordinary skill in the art to understand the various embodiments disclosed herein.

Claims (10)

1. A biopsy data visualization system, comprising a computer control system, and further comprising:

a tissue marker for marking a lesion location;

the radiography system is used for radiography of the focus tissues, acquiring focus position images and biopsy sampling image data in real time and sending the focus position images and the biopsy sampling image data to the computer control system;

the temperature sensing system is used for acquiring the real-time temperature of the lesion tissue and/or the cutting sleeve and/or the cryogenic cooling adhesion probe and sending the real-time temperature to the computer control system;

a display for receiving and displaying the lesion location image and biopsy sampling image data and real-time temperature data;

the radiography system, the temperature sensing system and the display are respectively in communication connection with the computer control system.

2. The biopsy data visualization system of claim 1, wherein the tissue marker is of a material that is visualized under the contrast system.

3. The biopsy data visualization system of claim 1, wherein the visualization system comprises:

the image acquisition module is used for acquiring and sending the photographic image in real time;

the image processing module is used for receiving the contrast image and preprocessing the contrast image through an image preprocessing algorithm to obtain a preprocessed contrast image; and digitally encrypting the preprocessed contrast image and transmitting the image;

and the image storage module is used for receiving and storing the digital encrypted image and sending the digital encrypted image to the computer control system through a digital encryption channel.

4. The biopsy data visualization system of claim 1, wherein the temperature sensing system comprises:

the temperature detection chip is arranged on the focal tissue and/or the cutting sleeve and/or the cryogenic cooling adhesion probe and is used for correspondingly acquiring and sending real-time temperature data;

and the communication chip is electrically connected with the temperature detection chip and is used for receiving the real-time temperature data and sending the real-time temperature data to the computer control system.

5. The utility model provides a biopsy device, includes shell and pneumatic system, pneumatic system locates in the shell, its characterized in that still includes:

the biopsy data visualization system of any one of claims 1-4, for real-time image visualization, guiding biopsy sampling;

the cryogenically-cooled adhesion probe is used for moving to a focus position and cryogenically cooling and fixing the focus under the assistance of the biopsy data visualization system;

the cutting sleeve is used for moving to the position of the fixed lesion and carrying out low-temperature biopsy sampling under the assistance of the biopsy data visualization system;

the cryogenic cooling adhesion probe is coaxially and movably arranged in the cutting sleeve and is driven by the pneumatic system.

6. The biopsy device of claim 5, further comprising:

a delivery needle for delivering a tissue marker in the biopsy data visualization system to the focal tissue location with the assistance of the biopsy data visualization system; and after the biopsy is finished, moving the tissue marker in the biopsy data visualization system out of the body surface from the lesion tissue position with the assistance of the biopsy data visualization system.

7. The biopsy device of claim 6, wherein the delivery needle or the tip portion of the delivery needle is made of a material that is visualized under the contrast system of the biopsy data visualization system.

8. The biopsy device of claim 6 or 7, further comprising:

a biopsy instrument sealingly fitted within the mounting cavity of the housing, the cutting cannula sealingly fitted within the cutting cannula;

the tank is fixedly arranged on the shell;

the compressed gas tank is matched in the tank cylinder;

the valve group is arranged and fixedly arranged on the shell, the input end of the valve group is connected with the compressed gas tank, and the output end of the valve group is connected with the pneumatic system.

9. The biopsy device of claim 8, further comprising:

a pierce pin connector provided at a passage between the canister and the valve block, a gas outlet of the compressed gas tank being fitted on the pierce pin connector;

releasing compressed gas into the valve block by the pierce pin connector piercing a gas outlet of the compressed gas tank when the compressed gas tank is mated within the canister.

10. The biopsy device of claim 8, wherein the pneumatic system is a servo-driven system, and comprises a computer control system, a battery, a motor, and a gear box, the battery is electrically connected to the computer control system and the motor, respectively, the motor is connected to the gear box, and the output end is disposed on the gear box and keeps rotating at a constant speed.

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