CN114344560A - Roughening treatment technology for surface of bone implant prosthesis - Google Patents
Roughening treatment technology for surface of bone implant prosthesis Download PDFInfo
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- CN114344560A CN114344560A CN202111653188.6A CN202111653188A CN114344560A CN 114344560 A CN114344560 A CN 114344560A CN 202111653188 A CN202111653188 A CN 202111653188A CN 114344560 A CN114344560 A CN 114344560A
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- bone implant
- implant prosthesis
- roughening treatment
- treatment technology
- bone
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 74
- 239000007943 implant Substances 0.000 title claims abstract description 63
- 238000007788 roughening Methods 0.000 title claims abstract description 20
- 238000005516 engineering process Methods 0.000 title claims abstract description 18
- 238000002791 soaking Methods 0.000 claims abstract description 25
- 238000005507 spraying Methods 0.000 claims abstract description 21
- 239000011148 porous material Substances 0.000 claims abstract description 20
- 239000012670 alkaline solution Substances 0.000 claims abstract description 11
- 238000002347 injection Methods 0.000 claims abstract description 8
- 239000007924 injection Substances 0.000 claims abstract description 8
- 239000011261 inert gas Substances 0.000 claims abstract description 6
- 238000004140 cleaning Methods 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 12
- 239000010936 titanium Substances 0.000 claims description 11
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 229910017604 nitric acid Inorganic materials 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 5
- 229910052719 titanium Inorganic materials 0.000 claims description 5
- MTHLBYMFGWSRME-UHFFFAOYSA-N [Cr].[Co].[Mo] Chemical compound [Cr].[Co].[Mo] MTHLBYMFGWSRME-UHFFFAOYSA-N 0.000 claims description 2
- 239000007769 metal material Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 6
- 239000004576 sand Substances 0.000 description 4
- 238000004381 surface treatment Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000005422 blasting Methods 0.000 description 3
- 230000007797 corrosion Effects 0.000 description 3
- 238000005260 corrosion Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000010883 osseointegration Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 208000032984 Intraoperative Complications Diseases 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- UMUXBDSQTCDPJZ-UHFFFAOYSA-N chromium titanium Chemical compound [Ti].[Cr] UMUXBDSQTCDPJZ-UHFFFAOYSA-N 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 229910000476 molybdenum oxide Inorganic materials 0.000 description 1
- PQQKPALAQIIWST-UHFFFAOYSA-N oxomolybdenum Chemical group [Mo]=O PQQKPALAQIIWST-UHFFFAOYSA-N 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
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- Prostheses (AREA)
Abstract
The invention provides a roughening treatment technology for the surface of a bone implant prosthesis, which comprises the following steps: s1, carrying out injection treatment on the bone implant prosthesis; s2, removing the oxide layer on the surface of the substance obtained in the step S1; and S3, soaking the bone implant prosthesis processed in the step S2 to form pores in the formed pores, taking out the bone implant prosthesis, spraying inert gas environment, and putting the bone implant prosthesis into alkaline solution for cleaning and storing. The advantages are that: the multi-stage holes formed on the surface of the prosthesis can form a bone combination area between bone tissues and the prosthesis, namely, the strength of the prosthesis is not influenced, and meanwhile, the bone combination efficiency is improved.
Description
Technical Field
The invention relates to the technical field of prosthesis manufacturing, in particular to a roughening treatment technology for the surface of a bone implanted prosthesis.
Background
The surfaces of osseous implant products are currently treated by various surface treatment techniques, with the aim of making the prosthesis rough and at the same time providing sufficient space for the osseous tissue to complete the osseous ingrowth. The osseointegration of the implant is an important reason for the contact between the implant and the bone tissue and for maintaining a stable structure. Host factors (physiological conditions, bone mass and the like of a patient) and iatrogenic factors (surgical injury, load opportunity and the like) are removed, and the most important influencing factor influencing the osseointegration is the surface treatment of the implant;
however, the prior art for rough treatment of the surface of the bone implant prosthesis still has many disadvantages, such as the problem of coating detachment for clinical end feedback cannot be solved, and the surface of the product after surface treatment still has an oxide layer, which seriously affects the healing cycle of the product, and so on.
Disclosure of Invention
The invention provides a roughening treatment technology for the surface of a bone implant prosthesis, which aims to overcome at least one technical defect, provide more bone combination space for bone tissues after the bone implant prosthesis is implanted and shorten the healing period.
In order to achieve the above purpose, the invention provides the following technical scheme:
a roughening treatment technique for the surface of a bone implant prosthesis, comprising:
s1, carrying out jet treatment on the bone implant prosthesis, and forming a plurality of holes with unequal spans on the surface of the bone implant prosthesis;
s2, removing the oxide layer on the surface of the substance obtained in the step S1;
and S3, soaking the bone implant prosthesis processed in the step S2 to form pores in the formed pores, taking out the bone implant prosthesis, spraying inert gas environment, and putting the bone implant prosthesis into alkaline solution for cleaning and storing.
Preferably, in the step S1, the injection pressure is greater than or equal to 0.5MPa and less than or equal to 3MPa, and the injection time is 0.5-3 min; the medium is 5-100 meshes.
Preferably, in step S1, the bone implant prosthesis is made of one of pure titanium, cobalt chromium molybdenum or titanium-grade metal material.
Preferably, in step S2, the bone implant prosthesis obtained in step S1 is soaked in solution A prepared by mixing concentrated nitric acid, concentrated hydrofluoric acid and water according to the ratio of x: y: 100-x-y;
wherein x is 1-5, and y is 1-5.
Preferably, the soaking time of the solution A in the step S2 is 10-25 min, and the temperature is 20-40 ℃.
Preferably, in step S3, the bone implant prosthesis obtained in step S2 is soaked in a solution B prepared by mixing concentrated hydrochloric acid, concentrated sulfuric acid and water at a ratio of x: y:100-x-y to form pores of 2um to 20um in the pores;
wherein x is 15-35, and y is 15-35.
Preferably, the soaking time of the solution A in the step S3 is 25-40 min, and the temperature is 65-85 ℃.
Preferably, in step S3, Na is contained in the alkaline solution2HCO3And Na2HCO3The concentration of (A) is 0.2-0.8%.
Preferably, the time from taking out to putting into the alkaline solution in step S3 is 3min or less.
Preferably, the media used for the ejection process in step S1 are: the bone is implanted with oxide particles of prosthetic material.
The invention relates to a roughening treatment technology for the surface of a bone implant prosthesis, which has the advantages that:
1. the method comprises the steps of firstly forming an oxide layer on the surface of the bone implant prosthesis and simultaneously forming a multi-stage hole structure (namely forming a plurality of holes with different spans on the surface of the bone implant prosthesis, wherein the span range is 2-50um), then removing the oxide layer on the surface and residual sand grains, then soaking the surface of the bone implant prosthesis by a soaking solution to form holes (the hole span is 2-20um) in the hole structure, providing a space for the growth of bone tissues, and finally spraying the holes without a professional workshop, wherein the roughening surface treatment can be completed without independently establishing a special workshop, so that the production cost is greatly reduced;
2. the selection of the special medium in the step S1 prevents the medium from being bonded with the prosthesis, and other element materials cannot be introduced into the same material; in the step S2, the strong corrosivity of the solution A is utilized to remove the surface oxide layer, and meanwhile, the problem of sand residue caused by the first-step spraying can be solved; in the step S3, the surface of the implant is corroded by using the corrosivity of the solution B, the soaking time mainly influences the surface hole forming effect, and the soaking temperature mainly influences the reaction rate;
3. the roughening treatment technology of the invention does not worry about the falling problem of the coating during implantation; other elements except the body cannot be introduced in the processing process, so that the biological risk is reduced, and the risk of escaping of the spraying material is reduced; an oxide layer is not formed on the surface of the finally formed product, so that the bone healing period is accelerated, and the long-term stability is facilitated;
4. the roughening treatment technology of the invention ensures that the multilevel holes formed on the surface of the prosthesis can form a bone combination area (2 um-50 um) between the bone tissue and the prosthesis, namely, the strength of the prosthesis is not influenced, and simultaneously, the bone combination efficiency is also improved.
Drawings
The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention. In the drawings:
FIG. 1, FIG. 2 and FIG. 3 are schematic views of holes with different spans on the surface of a product obtained by the method according to the embodiment;
fig. 4, 5, 6, and 7 are the topography maps of the fourth embodiment, the fifth embodiment, the sixth embodiment, and the seventh embodiment after step S3, respectively, wherein the etching effect is mainly embodied.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly or indirectly secured to the other element. When an element is referred to as being "connected to" another element, it can be directly or indirectly connected to the other element. The terms "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positions based on the orientations or positions shown in the drawings, and are for convenience of description only and not to be construed as limiting the technical solution. The terms "first", "second" and "first" are used merely for descriptive purposes and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features. The meaning of "plurality" is two or more unless specifically limited otherwise.
Book (I)
The first embodiment is as follows:
s1, spraying the bone implant prosthesis made of pure titanium for 0.5min at the normal temperature under the pressure of 0.5Mpa, wherein the spraying medium is titanium oxide particles with the particle size of 5 meshes; forming a layer of oxide film on the surface of the prosthesis after high-pressure spraying;
in the concrete implementation process, dry spraying (directly adopting compressed air as power to form high-speed spray beams to spray Ti) can be selected during the injection in the step2O-jet) or wet blasting (using compressed air as a motive force to form a high velocity jet of Ti2Mixture of O and water is sprayed);
s2, soaking the bone implant prosthesis obtained in the step S1 in solution A prepared by mixing concentrated nitric acid, concentrated hydrofluoric acid and water according to the ratio of x: y:100-x-y (wherein x is 1, and y is 1) at 20 ℃ for 10min, removing an oxide layer on the surface of the prosthesis by utilizing the strong corrosivity of the solution A, and simultaneously solving the problem of sand grain residue caused by the first-step spraying;
s3, soaking the bone implant prosthesis processed in the step S2 in a solution B prepared by mixing concentrated hydrochloric acid, concentrated sulfuric acid and water according to the proportion of x: y:100-x-y (wherein x is 15, and y is 15) at 65 ℃ for 25min, corroding the surface of the implant by utilizing the corrosivity of the solution B, forming pores in the pores, providing space for bone tissue growth, wherein the length of soaking time mainly influences the formation effect of the surface pores, and the soaking temperature mainly influences the reaction rate;
taking out, injecting inert gas environment, and adding Na with concentration of 0.2%2HCO3The alkaline solution (the time required for taking out and putting in the process is 2min) is cleaned, and then the alkaline solution is taken out and put in NaCl solution with the concentration of 8% for preservation (the topographic map of the product obtained in the embodiment is shown in figures 1-3, which is a topographic map of holes with different spans).
Example two:
s1, spraying the bone implant prosthesis prepared from cobalt, chromium and molybdenum at 2Mpa and normal temperature for 1.5min, wherein the spraying medium is molybdenum oxide particles with the particle size of 60 meshes; forming a layer of oxide film on the surface of the prosthesis after high-pressure spraying;
in the concrete implementation process, dry spraying (directly adopting compressed air as power to form high-speed spray beams to spray Ti) can be selected during the injection in the step2O-jet) or wet blasting (using compressed air as a motive force to form a high velocity jet of Ti2Mixture of O and water is sprayed);
s2, soaking the bone implant prosthesis obtained in the step S1 for 18min at 30 ℃ by using solution A prepared by mixing concentrated nitric acid, concentrated hydrofluoric acid and water according to the ratio of x: y:100-x-y (wherein x is 3, and y is 3), removing an oxide layer on the surface of the prosthesis by using the strong corrosivity of the solution A, and simultaneously solving the problem of sand grain residue caused by the first-step spraying;
s3, soaking the bone implant prosthesis processed in the step S2 in a solution B which is prepared by mixing concentrated hydrochloric acid, concentrated sulfuric acid and water according to the proportion of x: y:100-x-y (wherein x is 25, y is 25) at 65 ℃ for 25min, corroding the surface of the implant by utilizing the corrosivity of the solution B, forming pores of 10um in the pores, providing space for the growth of bone tissues, wherein the length of the soaking time mainly influences the formation effect of the pores on the surface, and the soaking temperature mainly influences the reaction rate;
taking out, injecting inert gas environment, and adding Na with concentration of 0.5%2HCO3Washing with alkaline solution (2 min for the process), and storing in 13% NaCl solution.
Example three:
s1, spraying the bone implant prosthesis made of pure titanium for 3min at normal temperature under 3Mpa, wherein the spraying medium is titanium oxide particles with the particle size of 100 meshes; forming a layer of oxide film on the surface of the prosthesis after high-pressure spraying;
in the concrete implementation process, dry spraying (directly adopting compressed air as power to form high-speed spray beams to spray Ti) can be selected during the injection in the step2O-jet) or wet blasting (using compressed air as a motive force to form a high velocity jet of Ti2Mixture of O and water is sprayed);
s2, soaking the bone implant prosthesis obtained in the step S1 for 25min at 40 ℃ by using solution A prepared by mixing concentrated nitric acid, concentrated hydrofluoric acid and water according to the ratio of x: y:100-x-y (wherein x is 5, and y is 5), removing an oxide layer on the surface of the prosthesis by using the strong corrosivity of the solution A, and simultaneously solving the problem of sand grain residue caused by the first-step spraying;
s3, soaking the bone implant prosthesis processed in the step S2 in a solution B which is prepared by mixing concentrated hydrochloric acid, concentrated sulfuric acid and water according to the proportion of x: y:100-x-y (wherein x is 35, and y is 35) at 65 ℃ for 25min, corroding the surface of the implant by utilizing the corrosivity of the solution B, forming pores of 20um in the pores, providing space for the growth of bone tissues, wherein the length of the soaking time mainly influences the formation effect of the pores on the surface, and the soaking temperature mainly influences the reaction rate;
taking out, injecting inert gas environment, and adding Na with concentration of 0.8%2HCO3Washing with alkaline solution (2 min for the process), and storing in 20% NaCl solution.
Example four:
the difference from the first embodiment is that:
in step S3, the solution B is soaked at 50 ℃ for 10min, and titanium oxide particles are used for the bone implant prosthesis, as shown in fig. 4, Ti2O remains on the surface, and no suitable pores are formed.
Example five:
the difference from the first embodiment is that:
in step S3, the solution B is soaked at 65 ℃ for 10min, and the titanium oxide particles are used for the bone implant prosthesis, as shown in fig. 5, the surface of the bone implant prosthesis has Ti2O residues, and no suitable holes are formed, which is better than that in fig. 1, but the multi-level holes are not obvious.
Example six:
the difference from the first embodiment is that:
in step S3, the solution B is soaked at 50 ℃ for 50min, and the titanium oxide particles are used for the bone implant prosthesis, as shown in fig. 6, which shows a strong corrosion effect pattern, some holes are formed, but no suitable multi-stage holes are formed.
Example seven:
the difference from the first embodiment is that:
in step S3, the solution B is soaked at 65 ℃ for 50min, and the bone implant prosthesis uses titanium oxide particles, as shown in fig. 7, a strong corrosion effect pattern is obtained, and no holes are formed, but only a large corrosion effect is obtained.
The principles or steps explicitly described in the present invention are all available to those skilled in the art through conventional technical solutions, and therefore, are not described in detail.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (10)
1. A roughening treatment technology for the surface of a bone implant prosthesis is characterized in that: comprises the following steps
S1, carrying out jet treatment on the bone implant prosthesis, and forming a plurality of holes with unequal spans on the surface of the bone implant prosthesis;
s2, removing the oxide layer on the surface of the substance obtained in the step S1;
and S3, soaking the bone implant prosthesis processed in the step S2 to form pores in the formed pores, taking out the bone implant prosthesis, spraying inert gas environment, and putting the bone implant prosthesis into alkaline solution for cleaning and storing.
2. The roughening treatment technology for the surface of bone implant prosthesis according to claim 1, wherein: in the step S1, the injection pressure is more than or equal to 0.5Mpa and less than or equal to 3Mpa, and the injection time is 0.5-3 min; the medium is 5-100 meshes.
3. The roughening treatment technology for the surface of bone implant prosthesis according to claim 1, wherein: in step S1, the bone implant prosthesis is made of one of pure titanium, cobalt chromium molybdenum or titanium grade metal material.
4. The roughening treatment technology for the surface of bone implant prosthesis according to claim 1, wherein: in step S2, soaking the bone implant prosthesis obtained in step S1 in solution A prepared by mixing concentrated nitric acid, concentrated hydrofluoric acid and water according to the ratio of x: y: 100-x-y;
wherein x is 1-5, and y is 1-5.
5. The roughening treatment technology for the surface of bone implant prosthesis according to claim 4, wherein: in the step S2, the solution A is used for soaking for 10-25 min at the temperature of 20-40 ℃.
6. The roughening treatment technology for the surface of bone implant prosthesis according to claim 1, wherein: in step S3, soaking the bone implant prosthesis obtained in step S2 in a solution B prepared by mixing concentrated hydrochloric acid, concentrated sulfuric acid and water according to the ratio of x: y:100-x-y to form pores of 2-20um in the pores;
wherein x is 15-35, and y is 15-35.
7. The roughening treatment technology for the surface of bone implant prosthesis according to claim 6, wherein: in the step S3, the solution A is used for soaking for 25-40 min at the temperature of 65-85 ℃.
8. The roughening treatment technology for the surface of bone implant prosthesis according to claim 1, wherein: in step S3, the alkaline solution contains Na2HCO3And Na2HCO3The concentration of (A) is 0.2-0.8%.
9. The roughening treatment technology for the surface of bone implant prosthesis according to claim 1, wherein: in step S3, the time from taking out to putting in the alkaline solution is less than or equal to 3 min.
10. The roughening treatment technology for the surface of bone implant prosthesis according to claim 1, wherein: the media used for the ejection process in step S1 are: the bone is implanted with oxide particles of prosthetic material.
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| CN202111653188.6A CN114344560A (en) | 2021-12-30 | 2021-12-30 | Roughening treatment technology for surface of bone implant prosthesis |
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| CN202111653188.6A CN114344560A (en) | 2021-12-30 | 2021-12-30 | Roughening treatment technology for surface of bone implant prosthesis |
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Cited By (1)
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