CN114343170A - A kind of effervescent tablet containing creatine and preparation method thereof - Google Patents

Abstract

The present application relates to an effervescent tablet containing creatine and a preparation method thereof. The creatine-containing effervescent tablet comprises the following components: 10-30 parts by weight of creatine, 10-30 parts by weight of synergistic filler, 40-80 parts by weight of disintegrant, 2-5 parts by weight of lubricant, sweetener 0-10 parts by weight of the flavoring agent, and 0-10 parts by weight of the corrective agent, wherein the disintegrating agent includes an acid agent and an alkali agent. The effervescent tablet can improve the absorption rate of creatine in the human body and the stability of the product system, and solve the problems of browning and attenuation during the shelf life of the product. The preparation method according to the present application is simple and quick, and can provide an effervescent tablet containing creatine with better stability.

Description

A kind of effervescent tablet containing creatine and preparation method thereof

Technical field:

The application belongs to the field of food and health care products, and in particular, relates to an effervescent tablet containing creatine and a preparation method thereof.

Background technique:

Creatine is a precursor of phosphocreatine, a muscle strength enhancer widely used in sports nutrition. Creatine phosphate is a "backup source" of energy, which enables ATP to be resynthesized when ATP levels drop. Studies have shown that creatine supplementation can increase muscle phosphocreatine reserves and help improve the resynthesis of ATP and phosphocreatine during exercise, thereby improving exercise performance. Sexual exercise has a potentiating effect.

Meta-analysis showed that oral creatine and resistance training at the same time can make the subjects increase muscle and strength more significantly. In addition to resistance training, which can affect creatine absorption, athletes may benefit from supplementing fast-absorbing carbohydrates for a shorter period of time during creatine intake, since insulin also promotes intramuscular creatine storage.

However, due to the nature of creatine itself, the raw material has been subject to many restrictions in product application. First of all, the raw material of creatine is synthesized from arginine, methionine and glycine. It is a compound containing amino groups. When it is directly mixed with carbohydrates containing carbonyl groups, Maillard reaction is very likely to occur under certain temperature conditions. ), resulting in non-enzymatic browning, which affects the appearance of the product and reduces the nutritional value of the product; secondly, the solubility of creatine in aqueous solution at room temperature is very low, and it will be attenuated during storage in neutral or acidic solutions and converted into muscle Acid anhydrides, which lose their role in muscle cells, are excreted in urine.

Chinese patent application CN107035C discloses a creatine beverage and its production method. The production method of the invention includes: heating water to be weakly alkaline; adding crystalline creatine powder to the hot In water; the creatine powder is dissolved by stirring to form a creatine aqueous solution, which is then flavored and sterilized to obtain a creatine beverage. The method can improve the stability of the creatine solution during storage by adjusting the pH of the creatine solution, but weakly alkaline beverages usually have poor palatability, and the problem of yeast and bacteria exceeding the standard due to incomplete sterilization is likely to occur during the production process.

Therefore, it is necessary to develop a health product that can improve the absorption rate of creatine in the human body and the stability of the product system.

Invention content:

In view of the deficiencies in the above-mentioned prior art, an object of the present application is to provide an effervescent tablet containing creatine. The effervescent tablet can improve the absorption rate of creatine in the human body and the stability of the product system, and solve the problems of browning and attenuation during the shelf life of the product. In addition, the effervescent tablet form is also a new dosage form of creatine products, which fills the market gap.

Another object of the present application is to provide a preparation method of the above-mentioned effervescent tablet containing creatine. The preparation method is simple and quick, and can provide effervescent tablets containing creatine with better stability.

In order to achieve the above object, in a first aspect, the application provides an effervescent tablet containing creatine, which comprises the following components:

Wherein, the disintegrating agent includes an acid agent and an alkali agent.

With reference to the first aspect, in a feasible embodiment, the synergistic filler comprises glucose, Curcumin, Black Pepper Extract and Zinc Sulfate.

With reference to the first aspect, in a feasible embodiment, in the disintegrating agent, the weight ratio of the acid agent to the alkali agent is (1-2):(2-1).

Further, the acid agent is at least one selected from tartaric acid, malic acid and citric acid.

Further, the alkali agent is at least one selected from sodium carbonate, sodium bicarbonate and potassium bicarbonate.

In combination with the first aspect, in a feasible embodiment, the lubricant is at least one selected from polyethylene glycol 6000, silicon dioxide, sodium stearyl fumarate, leucine and sodium benzoate.

In combination with the first aspect, in a feasible embodiment, the sweetener is at least one selected from the group consisting of sucralose, acesulfame potassium, aspartame and steviol glycosides.

In combination with the first aspect, in a feasible embodiment, the flavoring agent is at least one selected from the group consisting of orange flavor essence, lemon flavor essence, apple flavor essence, cantaloupe flavor essence and banana flavor essence.

In the second aspect, the application provides a preparation method of the above-mentioned effervescent tablet containing creatine, comprising:

(1) mix creatine and alkali agent with 5% PVP ethanol solution, granulate, and dry the wet granules afterwards;

(2) mixing the synergistic filler and acid agent with the ethanol solution of 5% PVP, granulating, and drying the wet granules afterwards;

(3) coating the results of step (1) and step (2) respectively, and controlling the weight gain of the coating layer to be between 2% and 4%;

(4) Mix the coated material in step (3) evenly, add sweetener and flavoring agent and mix well, then add lubricant, continue to mix evenly, and press into tablets.

In combination with the second aspect, in a feasible embodiment, in the step (1), the dosage of the 5% PVP ethanol solution is (0.15-0.25) mL/g creatine, preferably 0.20 mL/g muscle acid.

In combination with the second aspect, in a feasible embodiment, in the step (1), the materials are uniformly mixed and then granulated with a 14-mesh sieve.

In combination with the second aspect, in a feasible embodiment, in the step (1), the drying is at 45°C to 55°C, preferably 50°C for 1.5h to 2.5h, preferably 2h.

With reference to the second aspect, in a feasible embodiment, the step (1) further includes: placing the dried granules in a dryer for natural cooling, and then 20-mesh granulation.

In combination with the second aspect, in a feasible embodiment, in the step (2), the dosage of the 5% PVP ethanol solution is (0.20-0.25) mL/g synergistic filler, preferably 0.235 mL/g g Synergistic filler.

In combination with the second aspect, in a feasible embodiment, in the step (2), the materials are uniformly mixed and then granulated with a 14-mesh sieve.

In combination with the second aspect, in a feasible embodiment, in the step (2), the drying is at 45°C to 55°C, preferably 50°C for 1.5h to 2.5h, preferably 2h.

With reference to the second aspect, in a feasible embodiment, the step (2) further includes: placing the dried granules in a dryer for natural cooling, and then 20-mesh granulation.

In combination with the second aspect, in a feasible embodiment, in the step (3), the coating is: spraying the coating liquid on the results of the step (1) and the step (2) respectively, and at the same time at 40r /min ~ 60r/min, preferably blow drying at a rotating speed of 50min.

Further, the coating solution is a solution with a concentration of 3% prepared by dissolving at least one selected from hydroxypropyl methylcellulose, ethyl cellulose and polyacrylic acid resin in 95v/v% alcohol .

Further, the air temperature of the blast is controlled at 40°C to 60°C, preferably 50°C.

With reference to the second aspect, in a feasible embodiment, the environment temperature and humidity conditions of the preparation method are: the temperature is controlled below 25° C., and the humidity is controlled below 30Rh%.

According to the technical solution provided by the application, compared with the prior art, at least the following beneficial effects are included:

The effervescent tablet containing creatine according to the present application can improve the absorption rate of creatine in the human body and the stability of the product system, and solve the problems of browning and attenuation during the shelf life of the product.

In addition, the preparation method according to the present application is simple and quick, and can provide an effervescent tablet containing creatine with better stability.

Description of drawings

FIG. 1 is the appearance comparison result of the stability test of the creatine effervescent tablet of Experimental Example 1 according to an embodiment of the present application.

Detailed ways

In order to enable those skilled in the art to understand the present application more clearly, the present application will be described in detail below with reference to the embodiments. Before proceeding with the description, it should be understood that the terms used in this specification and the appended claims should not be construed to be limited to ordinary and dictionary meanings, but should be used in the context of allowing the inventor to properly define the terms for best interpretation On the basis of the principles of the present application, interpretations are made according to the meanings and concepts corresponding to the technical aspects of the present application. Accordingly, the description set forth herein is for illustrative purposes only of preferred examples and is not intended to limit the scope of the application, whereby it is to be understood that other equivalents may be derived therefrom without departing from the spirit and scope of the application The scope of protection claimed in this application shall be subject to the scope defined by the claims. Unless otherwise specified, the reagents and instruments used in the following examples are commercially available products.

This application is achieved through the following technical solutions:

In a first aspect, the application provides an effervescent tablet containing creatine, comprising the following components:

Wherein, the disintegrating agent includes an acid agent and an alkali agent.

In the present application, the effervescent tablet containing creatine can improve the absorption rate of creatine in the human body and the stability of the product system, and solve the problems of browning and attenuation during the shelf life of the product.

In the present application, according to a feasible embodiment, in the effervescent tablet containing creatine, the content of the creatine may be 10 to 30 parts by weight, for example, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight parts, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 28 parts by weight, 29 parts by weight or 30 parts by weight, or other specific values within the range; the content of the synergistic filler can be 10-30 Parts by weight, for example, can be 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight , 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 29 parts by weight or 30 parts by weight, or other specific parts within the range The content of the disintegrant can be 40 to 80 parts by weight, for example, it can be 40 parts by weight, 41 parts by weight, 42 parts by weight, 43 parts by weight, 44 parts by weight, 45 parts by weight, 46 parts by weight, 47 parts by weight parts by weight, 48 parts by weight, 49 parts by weight, 50 parts by weight, 51 parts by weight, 52 parts by weight, 53 parts by weight, 54 parts by weight, 55 parts by weight, 56 parts by weight, 57 parts by weight, 58 parts by weight, 59 parts by weight , 60 parts by weight, 61 parts by weight, 62 parts by weight, 63 parts by weight, 64 parts by weight, 65 parts by weight, 66 parts by weight, 67 parts by weight, 68 parts by weight, 69 parts by weight, 70 parts by weight, 71 parts by weight, 72 parts by weight parts by weight, 73 parts by weight, 74 parts by weight, 75 parts by weight, 76 parts by weight, 77 parts by weight, 78 parts by weight, 79 parts by weight or 80 parts by weight, or other specific values within the range; the lubricant The content of the sweetener can be 2 to 5 parts by weight, for example, it can be 2 parts by weight, 3 parts by weight, 4 parts by weight or 5 parts by weight, or other specific values within the range; the content of the sweetener can be 0 to 10 parts by weight, for example, 0 parts by weight, 1 part by weight, 2 parts by weight, 3 parts by weight, 4 parts by weight, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 parts by weight or 10 parts by weight, or other specific values within the range; and the content of the flavoring agent can be 0 to 10 parts by weight, for example, 0 parts by weight, 1 part by weight, 2 parts by weight, 3 parts by weight , 4 parts by weight, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 parts by weight or 10 parts by weight, or other specific values within the stated range. Within the range, the functions of each component can be effectively exerted, and the effect of improving the absorption rate and stability can be achieved synergistically.

With reference to the first aspect, in a feasible embodiment, the synergistic filler comprises glucose, Curcumin, Black Pepper Extract and Zinc Sulfate.

In the present application, the synergistic filler can be selected from compounds that can promote insulin release or improve insulin sensitivity, such as glucose, curcumin, black pepper extract and zinc sulfate, which can enable the body to better utilize the body to obtain creatine, so as to ensure that more creatine molecules enter the muscle system and improve the effect of creatine absorption. According to a feasible embodiment, the weight ratio of glucose, curcumin, black pepper extract and zinc sulfate may be (30, 35, 40, 45, 50, 55, 60, 65, 70, 75 or 80):( 10, 15, 20, 25 or 30): (0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10): (10, 15, 20, 25 or 30), or whatever other specific ratios within the stated range.

With reference to the first aspect, in a feasible embodiment, in the disintegrating agent, the weight ratio of the acid agent to the alkali agent is (1-2):(2-1), for example, it can be 1:1, 1:2, or 2:1, or other specific ratios within the stated range.

Further, the acid agent is at least one selected from tartaric acid, malic acid and citric acid.

Further, the alkali agent is at least one selected from sodium carbonate, sodium bicarbonate and potassium bicarbonate.

In combination with the first aspect, in a feasible embodiment, the lubricant is at least one selected from polyethylene glycol 6000, silicon dioxide, sodium stearyl fumarate, leucine and sodium benzoate.

In combination with the first aspect, in a feasible embodiment, the sweetener is at least one selected from the group consisting of sucralose, acesulfame potassium, aspartame and steviol glycosides. By adding a sweetener, the mouthfeel of the effervescent tablet can be improved.

In combination with the first aspect, in a feasible embodiment, the flavoring agent is at least one selected from the group consisting of orange flavor essence, lemon flavor essence, apple flavor essence, cantaloupe flavor essence and banana flavor essence. However, the present application is not limited to this.

In the second aspect, the application provides a preparation method of the above-mentioned effervescent tablet containing creatine, comprising:

(1) mix creatine and alkali agent with 5% PVP ethanol solution, granulate, and dry the wet granules afterwards;

(2) mixing the synergistic filler and acid agent with the ethanol solution of 5% PVP, granulating, and drying the wet granules afterwards;

(3) coating the results of step (1) and step (2) respectively, and controlling the weight gain of the coating layer to be between 2% and 4%;

(4) Mix the coated material in step (3) evenly, add sweetener and flavoring agent and mix well, then add lubricant, continue to mix evenly, and press into tablets.

In this application, because creatine has good stability under alkaline conditions, creatine is granulated with the alkali source, then coated, sieved and granulated to isolate the acid raw material and carbohydrates; Granulate with synergistic fillers (carbohydrates, etc.), then coat, sieve and granulate; finally, the obtained two granules are fully mixed with sweetener, flavoring agent and lubricant, and pressed by a tablet machine. The tablet is a finished product, thereby improving the stability of the effervescent tablet.

In combination with the second aspect, in a feasible embodiment, in the step (1), the dosage of the 5% PVP ethanol solution is (0.15-0.25) mL/g creatine, for example, 0.15 mL /g creatine, 0.16mL/g creatine, 0.17mL/g creatine, 0.18mL/g creatine, 0.19mL/g creatine, 0.20mL/g creatine, 0.21mL/g creatine, 0.22mL/ g creatine, 0.23 mL/g creatine, 0.24 mL/g creatine, or 0.25 mL/g creatine, or other specific values within the stated range, and preferably 0.20 mL/g creatine. The ethanolic solution of PVP is used as a binder to aid in granulation.

In combination with the second aspect, in a feasible embodiment, in the step (1), the materials are uniformly mixed and then granulated with a 14-mesh sieve. Thereby, the granulation size can be made uniform.

In combination with the second aspect, in a feasible embodiment, in the step (1), the drying is performed at 45°C to 55°C (for example, it may be 45°C, 46°C, 47°C, 48°C, 49°C, 50°C, 51°C, 52°C, 53°C, 54°C or 55°C, or other specific temperature values within the range), and preferably drying at 50°C for 1.5h to 2.5h (for example, it can be 1.5h, 1.6h, 1.7h, 1.8h, 1.9h, 2.0h, 2.1h, 2.2h, 2.3h, 2.4h or 2.5h, or other specific time values within the range), preferably 2h. Under this condition, the particles can be dried sufficiently.

With reference to the second aspect, in a feasible embodiment, the step (1) further includes: placing the dried granules in a dryer for natural cooling, and then 20-mesh granulation. The resulting granules are prevented from absorbing moisture by cooling in a desiccator.

In combination with the second aspect, in a feasible embodiment, in the step (2), the amount of the 5% PVP ethanol solution is (0.20-0.25) mL/g of a synergistic filler, for example, it can be 0.20mL/g synergistic filler, 0.205mL/g synergistic filler, 0.210mL/g synergistic filler, 0.215mL/g synergistic filler, 0.220mL/g synergistic filler, 0.225mL/g synergistic filler synergistic filler, 0.230mL/g synergistic filler, 0.235mL/g synergistic filler, 0.240mL/g synergistic filler, 0.245mL/g synergistic filler or 0.25mL/g synergistic filler, or are other specific values within the stated range, and preferably 0.235 mL/g of synergistic filler. The ethanolic solution of PVP is used as a binder to aid in granulation.

In combination with the second aspect, in a feasible embodiment, in the step (2), the materials are uniformly mixed and then granulated with a 14-mesh sieve. Thereby, the granulation size can be made uniform.

In combination with the second aspect, in a feasible embodiment, in the step (2), the drying is performed at 45°C to 55°C (for example, 45°C, 46°C, 47°C, 48°C, 49°C, 50°C, 51°C, 52°C, 53°C, 54°C or 55°C, or other specific temperature values within the range), and preferably drying at 50°C for 1.5h to 2.5h (for example, it can be 1.5h, 1.6h, 1.7h, 1.8h, 1.9h, 2.0h, 2.1h, 2.2h, 2.3h, 2.4h or 2.5h, or other specific time values within the range), preferably 2h. Under this condition, the particles can be dried sufficiently.

With reference to the second aspect, in a feasible embodiment, the step (2) further includes: placing the dried granules in a dryer for natural cooling, and then 20-mesh granulation. The resulting granules are prevented from absorbing moisture by cooling in a desiccator.

In combination with the second aspect, in a feasible embodiment, in the step (3), the coating is: spraying the coating liquid on the results of the step (1) and the step (2) respectively, and at the same time at 40r /min～60r/min (for example, can be 40r/min, 45r/min, 50r/min, 55r/min or 60r/min, or other specific values within the range), preferably blowing at a rotational speed of 50min dry.

Further, the coating solution is a solution with a concentration of 3% prepared by dissolving at least one selected from hydroxypropyl methylcellulose, ethyl cellulose and polyacrylic acid resin in 95v/v% alcohol . Coating by Cao Yong coating liquid can further effectively isolate creatine, and isolate acid and alkali.

Further, the air temperature of the blast is controlled at 40°C to 60°C (for example, it can be 40°C, 45°C, 50°C, 55°C or 60°C, or other specific temperature values within the range), 50°C is preferred. Coating can be effectively achieved by blowing hot air.

With reference to the second aspect, in a feasible embodiment, the environment temperature and humidity conditions of the preparation method are: the temperature is controlled below 25° C., and the humidity is controlled below 30Rh%. At this temperature, the deterioration and moisture absorption of the material can be delayed.

The effervescent tablet containing creatine according to the present application can improve the absorption rate of creatine in the human body and the stability of the product system, and solve the problems of browning and attenuation during the shelf life of the product. In addition, the preparation method according to the present application is simple and quick, and can provide an effervescent tablet containing creatine with better stability.

Example

Example 1

The creatine-containing effervescent tablet according to the present application was prepared using the following preparation method:

(1) Mix 250g of creatine and alkaline agent (200g of sodium bicarbonate and 50g of sodium carbonate) with 50mL of 5% PVP ethanol solution, granulate with a 14-mesh sieve, and then dry the wet granules at 50°C 2h, then placed in a desiccator for natural cooling, and then 20 mesh granules;

(2) 170 g of synergistic filler (120 g of glucose, 30 g of curcumin, 10 g of black pepper extract, and 40 g of zinc sulfate) and acid agent (120 g of citric acid and 100 g of tartaric acid) were mixed with 40 mL of 5% PVP ethanol solution Evenly, granulate with a 14-mesh sieve, then dry the wet granules at 50 °C for 2 hours, then place them in a dryer to cool naturally, and then granulate with a 20-mesh;

(3) spray the coating liquid (the solution with the concentration of 3% prepared by dissolving hydroxypropyl methylcellulose in 95v/v% alcohol) to the result of step (1) and step (2) respectively, and simultaneously Blow drying under the rotating speed of 50min, the air temperature is 50℃, and the weight gain of the coating layer is controlled at 3%;

(4) mix the material after step (3) coating, add the sweetener (aspartame) of 25g and the corrective (orange flavor essence) of 25g and mix fully, then add the lubricant of 30g ( polyethylene glycol 6000), continue to mix evenly, and press into tablets.

Example 2

The creatine-containing effervescent tablet according to the present application was prepared using the following preparation method:

(1) Mix 250g of creatine and alkaline agent (200g of sodium bicarbonate and 25g of sodium carbonate) with 50mL of 5% PVP ethanol solution, granulate with a 14-mesh sieve, and then dry the wet granules at 50°C 2h, then placed in a desiccator for natural cooling, and then 20 mesh granules;

(2) Mix 170 g of synergistic filler (100 g of glucose, 30 g of curcumin, 10 g of black pepper extract, and 60 g of zinc sulfate) and acid agent (250 g of citric acid) with 40 mL of 5% PVP ethanol solution, and use Granulate with a 14-mesh sieve, then dry the wet granules at 50°C for 2 hours, then place them in a desiccator for natural cooling, and then granulate with a 20-mesh;

(3) spray the coating liquid (the solution with the concentration of 3% prepared by dissolving hydroxypropyl methylcellulose in 95v/v% alcohol) to the result of step (1) and step (2) respectively, and simultaneously Blow drying under the rotating speed of 50min, the air temperature is 50℃, and the weight gain of the coating layer is controlled at 3%;

(4) mix the material after the coating of step (3), add 15g of sweeteners (10g of acesulfame potassium and 5g of sucralose) and 30g of correctives (lemon flavor essence) and fully mix, then add 30g of lubricant (10g of sodium benzoate and 20g of leucine), continue to mix evenly, and press into tablets.

Experimental example

The beneficial effects of the present application are further described below through experiments:

The creatine-containing effervescent tablets prepared in Examples 1 and 2 were subjected to the following evaluation experiments.

Experimental Example 1 Stability Test of Creatine Effervescent Tablets

1.1 Experimental sample: experimental group: the sample prepared in Example 1; control group: the formula is the same as in Example 1, and the material is directly mixed and compressed without granulation and coating.

1.2 Specifications and packaging material information:

Specification: 4g/tablet*18tablets/support; Packing material information: Oral solid medicinal low-density polyethylene moisture-proof combination bottle cap and polypropylene tube.

1.3 Accelerated test conditions:

The temperature is 37±2℃, the relative humidity is 75±5%, the experiment period is three months, and it is stored under the condition of avoiding direct light.

1.4 Accelerated test observation and item measurement:

Table 1 Accelerated Test Observation and Item Determination

1.5 Accelerated test conclusion:

As shown in Figure 1, during the stability test of the experimental group sample (Example 1), the color and luster are stable, and the color of one side is white to light yellow, and the color is uniform; After three months, the overall color of the tablet was dark brown, and the color changed obviously.

The flavor of the samples in the experimental group (Example 1) was stable during the stability test. After three months of the accelerated test, the orange flavor was slightly attenuated, but the overall flavor was within the acceptable range; during the accelerated test, the flavor of the samples in the control group had a burnt taste. The aggravating trend is considered to be caused by the Maillard reaction product.

The tissue state of the samples in the experimental group (Example 1) is firm, not loose, tight in profile, and not sticky; in the samples in the control group, the tablets are loose and the formability is not good. good.

During the stability test of the samples in the experimental group (Example 1), the creatine content decreased slightly, but the overall level was within the acceptable range; during the accelerated test, the creatine content of the control group samples decreased significantly, and the creatinine content was significantly increased, and the creatine content decreased by more than 30% after three months of accelerated testing.

To sum up, after comparison, the experimental group (Example 1) can significantly improve the stability of the product during the accelerated test period compared with the control group, and can solve the problems of browning and creatine decay during the shelf life of the product.

Experimental Example 2 Efficacy Test of Creatine Effervescent Tablets

2.1 Research objects

This study selected 24 male basketball players from a university as the research object. It has been reported that creatine levels in skeletal muscle returned to baseline levels about 30 days after supplementation was stopped. To ensure reliable experimental data, all subjects were required to have not taken anabolic steroid supplements and had not taken anabolic steroid supplements within 5 weeks before the experiment. Have not taken protein or creatine supplements. Before the experiment, the subjects filled out the informed consent form and agreed to obey the experimental arrangement.

According to the different supplements to be taken, the subjects were randomly divided into two groups, the experimental group (group A, n=8) and the control group (group B, n=8). All subjects did not drink alcohol, caffeine and other drug intake, stay up late, high-protein diet and other behaviors during the experiment. During the experiment, the subjects' daily activities were continuously monitored by information feedback, and the possible interference factors during the experiment were strictly controlled.

2.2 Research methods

2.2.1 Sports Supplements Taking and Testing Program

The experimental group A was given 2 pieces of the sample of Example 2 (the effervescent tablet containing creatine according to the present application), which was soaked in water to make a drink and taken in two doses, 30 minutes before exercise and after exercise. Control group B took pure creatine powder with the same efficacy dose, 30 minutes before exercise and after exercise in 2 doses. Subjects were required to test the basic indicators first, and then test each indicator at the same time after training before, 4 weeks, and 8 weeks after taking nutritional supplements. During the entire experimental period, the athletes carried out routine training according to the coach's plan, and no additional training was added.

2.2.3 Main test indicators and test methods

①Body composition index: X-SCAN PLUS II body composition analyzer (Beijing Kangbit Sports Technology Co., Ltd.) was used to measure body weight and lean body mass index.

②Indices of athletic ability: standing long jump, use the standing long jump measuring instrument (Beijing Xindong Huateng) to measure 2 times in a row, and take the longest distance.

2.3 Statistical methods

The statistical data of this experiment was analyzed and processed by SPSS 22.0 software. All results are expressed as mean ± standard deviation (mean ± SD). All indicators between and within groups were analyzed by one-way ANOVA, and the statistical results showed that the level of significant difference was P<0.05, and the level of very significant difference was P<0.01.

2.4 Research results

2.4.1 The effect of different supplements on the body composition index of subjects

Table 2 Changes in body weight of athletes (kg)

It can be seen from Table 2 that there was no significant difference in body weight indexes in the same group at each stage and in the comparison between each group (P>0.05).

Table 3 Changes in lean body mass of athletes (kg)

Note: */** means p<0.05/0.01 compared with the base value.

As can be seen from Table 3, in the comparison of each stage of the same group, the lean body mass of group A was significantly higher than the basal value after taking the supplement (the effervescent tablet containing creatine according to the present application) for 4 weeks (P<0.05). ), the lean body mass was significantly higher than the basal value after taking the supplement for 8 weeks (P<0.01), and the lean body mass of the control group B after taking the supplement (pure creatine powder) for 8 weeks was significantly higher than the basal value (P <0.05).

2.4.2 The effect of different supplements on the exercise ability index of subjects

Table 4 Athletes standing long jump test results (m)

Note: * means p < 0.05 compared with the baseline value; # means p < 0.05 compared with taking supplements for 4 weeks; superscript B means p < 0.05 compared with group B.

As can be seen from Table 4, the standing long jump performance of group A was significantly higher than the baseline value when taking supplements (effervescent tablets containing creatine according to the present application) for 8 weeks and when taking 4 weeks, and was comparable to control group B (pure muscle). Acid powder) also increased significantly (P < 0.05); the standing long jump score of group B after taking supplements (pure creatine powder) for 8 weeks was significantly higher than the baseline value of this group (P < 0.05).

2.5 Analysis and discussion

2.5.1 The effect of different supplements on the body composition index of the subjects

Body composition is an indicator that reflects the proportions of the internal structure of the human body, mainly referring to the content of various components in the body (such as muscle, fat, water and minerals, etc.), and is often expressed by the composition and proportion of various substances in the body.

In this study, there was no significant change in the body weight indicators of the two groups, but the lean body mass of the two groups A and B increased significantly after taking the supplement for 4 weeks (P < 0.05). The lean body mass of the effervescent tablet containing creatine of the present application has been significantly increased at 4 weeks, and there is a significant difference compared with the negative control group when taking 8 weeks. This shows that the supplements of both groups A and B have a relatively obvious effect of promoting the increase of body lean body mass, but the supplement of group A (the effervescent tablet containing creatine according to the present application) is better in terms of speed. The inventors believe that this is due to the influence of the absorption-promoting effect of the synergistic filler ingredients (glucose, curcumin, black pepper extract, caprylic acid) added to the Group A supplement.

2.5.2 The effect of different supplements on the exercise ability index of subjects

The standing long jump is the main method to evaluate the lower limb movement ability, muscle strength and explosive power of the body.

In this experiment, compared with the basal value before taking the supplement, the standing long jump scores of both groups A and B were significantly increased after taking the supplement for 8 weeks (p < 0.05), which means that the two groups of sports supplements were both significantly higher. Can promote the increase of muscle strength, while the group A took the supplement (the effervescent tablet containing creatine according to the present application) for 8 weeks and showed a significant improvement (p<0.05) compared with 4 weeks, indicating that the increase in muscle strength was promoted. In terms of speed, Group A supplements outperformed Group B supplements (pure creatine powder).

The reason for this effect of supplements A and B is mainly due to the creatine component contained in them. It has been reported that taking creatine can increase the storage of creatine phosphate in skeletal muscle, increase the rate of creatine phosphate resynthesis during the recovery period, and can significantly increase the muscle strength of fatigued isolated muscle tissue. In addition, the synergistic effect of adding synergistic fillers (glucose, curcumin, black pepper extract, octanosulfuric acid) and creatine in group A to enhance muscle strength increased the speed of muscle strength improvement in group A.

The above-mentioned specific embodiments of the present application are only preferred embodiments for explaining the present application, rather than limiting the present application. Those skilled in the art can make modifications without creative contribution as needed after reading this specification. However, any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this application shall be included within the protection scope of this application.

Claims (10)

1. an effervescent tablet containing creatine, is characterized in that, comprises the following components:

Wherein, the disintegrating agent includes an acid agent and an alkali agent. 2. The effervescent tablet according to claim 1, wherein the synergistic filler comprises a weight ratio of (30～80):(10～30):(0～10):(10～30) of glucose, curcumin, black pepper extract and zinc sulfate. 3. effervescent tablet according to claim 1, is characterized in that, in described disintegrating agent, the weight ratio of described acid agent and described alkali agent is (1～2): (2～1), Further, the acid agent is at least one selected from tartaric acid, malic acid and citric acid, Further, the alkali agent is at least one selected from sodium carbonate, sodium bicarbonate and potassium bicarbonate. 4. effervescent tablet according to claim 1, is characterized in that, The lubricant is at least one selected from polyethylene glycol 6000, silicon dioxide, sodium stearyl fumarate, leucine and sodium benzoate, The sweetener is at least one selected from sucralose, acesulfame potassium, aspartame and steviol glycosides, and The flavoring agent is at least one selected from orange flavor, lemon flavor, apple flavor, cantaloupe flavor and banana flavor. 5. a preparation method of the effervescent tablet containing creatine according to any one of claims 1 to 4, is characterized in that, comprises: (1) mix creatine and alkali agent with 5% PVP ethanol solution, granulate, and dry the wet granules afterwards; (2) mixing the synergistic filler and acid agent with the ethanol solution of 5% PVP, granulating, and drying the wet granules afterwards; (3) coating the results of step (1) and step (2) respectively, and controlling the weight gain of the coating layer to be between 2% and 4%; (4) Mix the coated material in step (3) evenly, add sweetener and flavoring agent and mix well, then add lubricant, continue to mix evenly, and press into tablets. 6. preparation method according to claim 5, is characterized in that, in described step (1), The dosage of the 5% PVP ethanol solution is (0.15-0.25) mL/g creatine, preferably 0.20 mL/g creatine, After the material is evenly mixed, it is granulated with a 14-mesh sieve. The drying is drying at 45°C～55°C, preferably 50°C for 1.5h～2.5h, preferably 2h, and The step (1) also includes: placing the dried granules in a desiccator for natural cooling, and then 20-mesh granulation. 7. preparation method according to claim 5, is characterized in that, in described step (2), The dosage of the 5% PVP ethanol solution is (0.20-0.25) mL/g synergistic filler, preferably 0.235mL/g synergistic filler, After the material is evenly mixed, it is granulated with a 14-mesh sieve. The drying is drying at 45°C～55°C, preferably 50°C for 1.5h～2.5h, preferably 2h, and The step (2) also includes: placing the dried granules in a dryer for natural cooling, and then 20-mesh granulation. 8. preparation method according to claim 5, is characterized in that, in described step (3), described coating is: spray coating liquid to the result of step (1) and step (2) respectively, simultaneously Blow dry at a rotating speed of 40r/min～60r/min, preferably 50min. 9. preparation method according to claim 8, is characterized in that, The coating solution is a solution with a concentration of 3% prepared by dissolving at least one selected from hydroxypropyl methylcellulose, ethyl cellulose and polyacrylic acid resin in 95v/v% alcohol, and The air temperature of the blast is controlled at 40°C to 60°C, preferably 50°C. 10 . The preparation method according to claim 5 , wherein the environment temperature and humidity conditions of the preparation method are: the temperature is controlled below 25° C. and the humidity is controlled below 30Rh%. 11 .

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