CN114246665A - Sound wave-assisted cryoablation knife - Google Patents
Sound wave-assisted cryoablation knife Download PDFInfo
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- CN114246665A CN114246665A CN202210049160.XA CN202210049160A CN114246665A CN 114246665 A CN114246665 A CN 114246665A CN 202210049160 A CN202210049160 A CN 202210049160A CN 114246665 A CN114246665 A CN 114246665A
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- knife
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B18/0206—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques ultrasonic, e.g. for destroying tissue or enhancing freezing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00041—Heating, e.g. defrosting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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Abstract
本发明公开了一种声波辅助冷冻消融刀，属于医疗器械领域，包括刀本体，所述刀本体的远端成型有刀头，所述刀本体上安装有声波振子，所述声波振子电性连接有输电导线；所述刀本体的内部安装有J‑T槽和翅片管，所述刀本体的近端一侧密封连接有进气管、回气管和中空状的芯轴，所述进气管、所述翅片管和所述J‑T槽依次相连；所述刀本体的内部还安装有测温元件，所述芯轴内穿设有与所述测温元件电性连接的传输导线。本发明结构简单且设计合理，能够有效提高冻融速率和冻融杀伤效果。
The invention discloses a sonic wave-assisted cryoablation knife, belonging to the field of medical equipment, comprising a knife body, a knife head is formed at the distal end of the knife body, a sound wave oscillator is installed on the knife body, and the sound wave oscillator is electrically connected There is a power transmission wire; a J-T groove and a fin tube are installed inside the knife body, and an air inlet pipe, a return air pipe and a hollow mandrel are sealed and connected to the proximal end side of the knife body, and the air inlet pipe, The finned tube and the J-T slot are connected in sequence; a temperature measuring element is also installed inside the knife body, and a transmission wire electrically connected to the temperature measuring element is passed through the mandrel. The invention has simple structure and reasonable design, and can effectively improve the freeze-thaw rate and the freeze-thaw killing effect.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a sound wave-assisted cryoablation knife.
Background
The cryoablation technology is an effective means for treating in-situ tumor, and the basic method is that high-pressure gas or liquefied gas flows through a Joule Thomson groove (J-T groove) inside a cryoablation knife (also called as an ablation needle), the knife head part of the cryoablation knife is cooled to a lower temperature through a gas throttling phenomenon, and the cold knife head contacts tumor tissue to cause the death of the tumor tissue.
When the conventional cryoablation knife, for example, a cryoablation needle with a rewarming function disclosed in patent document CN107714172A, is used, because the knife head cools and freezes tumor tissue by means of heat conduction, and the thermal conductivity of the tumor tissue is small, the temperature gradient inside the frozen tissue is often large, that is, when the tumor tissue near the cold knife head is cooled to-170 ℃, the temperature of the tissue 2cm away from the cold knife head is as high as-20 ℃. Thus causing a reduction in cryoablation efficiency.
In addition, in the actual use process, when the internal temperature of the tumor tissue is reduced to below the freezing point temperature, the tissue cells cannot be rapidly frozen into intracellular ice due to insufficient supercooling, so that the tissue cells cannot be effectively killed through the intracellular ice, and the intracellular ice cannot be generated through multiple freeze-thaw cycles, so that the tumor tissue cannot be killed by freeze-thawing, the treatment effect is not obvious, and the recurrence is easy.
Disclosure of Invention
Aiming at the problems of low freezing and thawing efficiency and low freezing and thawing killing effect of the freezing and ablating knife in the use process in the prior art, the invention aims to provide a sound wave auxiliary freezing and ablating knife.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a sound wave auxiliary cryoablation knife comprises a knife body, wherein a knife head is formed at the far end of the knife body, a sound wave vibrator is mounted on the knife body, and the sound wave vibrator is electrically connected with a power transmission lead; the cutter comprises a cutter body, a cutter head and a cutter head, wherein J-T grooves and finned tubes are arranged inside the cutter body, an air inlet pipe, an air return pipe and a hollow mandrel are hermetically connected to one side of the proximal end of the cutter body, and the air inlet pipe, the finned tubes and the J-T grooves are sequentially connected; the temperature measuring element is further installed inside the knife body, and a transmission lead electrically connected with the temperature measuring element penetrates through the mandrel.
Preferably, the sound wave oscillator is installed inside the knife body, and the power transmission lead penetrates out through the mandrel.
Preferably, the sound wave vibrator is mounted on the outer side wall of the knife body; the power transmission lead is laid along the outer side wall of the knife body, or the power transmission lead extends into the interior of the knife body through a through hole formed in the side wall of the knife body and penetrates out of the core shaft.
Preferably, the sound wave oscillator is annularly sleeved on the outer side of the knife body.
Furthermore, the temperature measurement device also comprises a sound wave generator and a temperature collection module, wherein the temperature collection module is electrically connected with the temperature measurement element through the transmission lead, and the sound wave generator is electrically connected with the sound wave oscillator through the transmission lead.
Preferably, there are two power transmission conductors, distal ends of the two power transmission conductors are electrically connected to the positive electrode and the negative electrode of the acoustic wave oscillator, respectively, and proximal ends of the two power transmission conductors are electrically connected to the positive electrode and the negative electrode of the acoustic wave generator, respectively.
Preferably, one of the positive electrode and the negative electrode of the acoustic wave oscillator is electrically connected to the distal end of the power transmission conductor, the other of the positive electrode and the negative electrode of the acoustic wave oscillator is electrically connected to the cutter head, and the positive electrode and the negative electrode of the acoustic wave generator are respectively electrically connected to the proximal end of the power transmission conductor and the cutter body.
Preferably, the temperature measuring element is a thermocouple.
Preferably, the ultrasonic vibrator, the J-T groove and the finned tube are sequentially arranged from the far end to the near end of the knife body.
Preferably, the acoustic wave transducer is an ultrasonic transducer.
By adopting the technical scheme, the invention has the beneficial effects that:
1. due to the arrangement of the acoustic wave vibrator, the frozen tissues can be vibrated through the acoustic waves emitted by the acoustic wave vibrator, and the contact action among the tissues is increased through vibration, so that the cold quantity is better transferred, the temperature difference in the tissues is reduced, and the freezing rate of the tissues is improved; in addition, forced convection can also occur in intercellular fluid and the interior of the cellular fluid under the action of sound wave vibration, so that the convection heat transfer coefficient is increased, and the cooling rate is further increased;
2. due to the arrangement of the acoustic wave vibrator, the supercooling degree of the tissue can be reduced by utilizing the cavitation effect of the ultrasonic wave emitted by the acoustic wave vibrator, so that ice crystals are quickly generated in the tissue cells at a high temperature, the formed intracellular ice can effectively kill the tissue cells, and the freezing-thawing killing effect on the tissue is improved;
3. due to the arrangement of the acoustic wave oscillator, ultrasonic heating can be carried out on the tissue after freeze thawing is completed through ultrasonic waves emitted by the acoustic wave oscillator, and therefore the effect of quick rewarming is achieved.
Drawings
FIG. 1 is a schematic structural diagram according to a first embodiment of the present invention;
fig. 2 is a schematic structural diagram of a second embodiment of the present invention.
In the figure, 1-knife body, 2-knife head, 3-sound wave vibrator, 4-J-T groove, 5-finned tube, 6-air inlet tube, 7-air return tube, 8-mandrel, 9-transmission wire, 10-temperature measuring element, 11-sound wave generator, 12-transmission wire, and 13-temperature collecting module.
Detailed Description
The following further describes embodiments of the present invention with reference to the drawings. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
It should be noted that in the description of the present invention, the terms "upper", "lower", "left", "right", "front", "rear", and the like indicate orientations or positional relationships based on structures shown in the drawings, and are only used for convenience in describing the present invention, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
In the technical scheme, the terms "first" and "second" are only used for referring to the same or similar structures or corresponding structures with similar functions, and are not used for ranking the importance of the structures, or comparing the sizes or other meanings.
In addition, unless expressly stated or limited otherwise, the terms "mounted" and "connected" are to be construed broadly, e.g., the connection may be a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; the two structures can be directly connected or indirectly connected through an intermediate medium, and the two structures can be communicated with each other. To those skilled in the art, the specific meanings of the above terms in the present invention can be understood in light of the present general concepts, in connection with the specific context of the scheme.
Example one
An acoustic wave-assisted cryoablation knife, as shown in fig. 1, comprises a knife body 1, the knife body 1 is a long strip structure made of metal material, the knife body 1 is hollow as a whole, a knife head 2 made of metal material is formed at the distal end of the knife body 1, and the distal end of the knife body 1 is sealed by the knife head 2, usually, the knife head 2 and the knife body 1 are integrally formed from the same material.
The acoustic wave vibrator 3, the J-T groove 4 and the finned tube 5 are arranged in the knife body 1, and the acoustic wave vibrator 3, the J-T groove 4 and the finned tube 5 are sequentially arranged from the far end to the near end of the knife body 1. In addition, the cutter head 2 is disposed on the distal side of the J-T groove 4. So set up for ultrasonic wave that sound wave oscillator 3 sent can transmit the outside tissue of tool bit 2 better on, and when the high-pressure draught took place the throttle cooling effect in J-T groove 4 department, tool bit 2 can fully obtain cold volume.
The dabber 8 that has intake pipe 6, muffler 7 and cavity form is connected to the near-end one side sealing of sword body 1, and in this embodiment, the distal end one side of intake pipe 6, muffler 7 and dabber 8 stretched into sword body 1, and near-end one side then communicates with the outside, sets up the shutoff stopper simultaneously at the near-end of sword body 1, seals intake pipe 6, muffler 7 and dabber 8 through the shutoff stopper. In the embodiment, the air inlet pipe 6, the finned tube 5 and the J-T groove are sequentially connected, and the finned tube 5 is spirally wound on the outer side of the mandrel 8 so as to reduce the occupied space.
And a power transmission lead 9 for electrically connecting the sound wave vibrator 3 is arranged in the core shaft 8 in a penetrating way. In this embodiment, two power transmission wires 9 are specifically configured, distal ends of the two power transmission wires 9 are electrically connected to the positive electrode and the negative electrode of the acoustic wave transducer 3, respectively, proximal ends of the two power transmission wires 9 are led out from the proximal end of the mandrel 8, and then are electrically connected to the positive electrode and the negative electrode of the acoustic wave generator 11, respectively, where the acoustic wave generator 11 is configured to input a high-frequency alternating current signal to the acoustic wave transducer 3, so as to drive the acoustic wave transducer 3 to operate and generate ultrasonic waves.
In addition, a temperature measuring element 10 is further installed inside the knife body 1, and a transmission lead 12 for electrically connecting with the temperature measuring element 10 is arranged in the core shaft 8 in a penetrating manner. For example, the temperature measuring element 10 is configured as a thermocouple, the acquired signal data is transmitted to the outside through the transmission lead 12, and the temperature data is acquired by the temperature acquisition module 13 and then transmitted to the temperature data of the knife body 1 (specifically, the knife head 2) to a worker or an automatic control system, so that the control of the sonic wave vibrator 3 and the control of the high-pressure air flow are performed according to the temperature data. In order to know the temperature of the tool head 2 more accurately, the temperature measuring element 10 is preferably arranged close to the tool head 2.
When the cutter is used, high-pressure gas is introduced through the gas inlet pipe 6, the high-pressure gas flows through the finned tube 5 and the J-T groove 4 in sequence, throttling phenomenon occurs at the J-T groove 4 to reduce the temperature, the throttled gas flows through the outer side of the finned tube 5 and flows out of the cutter body 1 through the gas return pipe 7, and the cutter head 2 at the far end side of the J-T groove 4 can be continuously cooled through continuous introduction of the high-pressure gas; in the cooling process, the temperature measuring element 10 can accurately know the real-time temperature of the cutter head 2, when the temperature of the cutter head 2 is reduced to a preset temperature, the flow velocity and the flow of high-pressure gas are selectively kept, reduced or suspended according to the freezing requirement, the sound wave generator 11 is used for driving the sound wave oscillator 3 to work, the sound wave oscillator 3 is enabled to send out ultrasonic waves with the frequency exceeding 20KHz, the corresponding sound wave generator 11 is configured as an ultrasonic wave generator, at the moment, the ultrasonic waves sent out by the sound wave oscillator 3 can vibrate the frozen tissues on one hand, the contact action among the tissues is increased through vibration, so that the cold quantity is better transmitted outwards, the temperature difference in the tissues is reduced, the freezing rate of the tissues is improved, on the other hand, the cavitation effect of the ultrasonic waves can be utilized to improve the crystallization temperature, the supercooling degree of the tissues is reduced, so that ice crystals are quickly generated in the tissue cells, and the tissue cells are effectively killed through the formed intracellular ice, thereby improving the effect of freeze thawing and killing tissues; after freezing and thawing, the acoustic wave vibrator 3 can also perform ultrasonic heating on the tissue after freezing and thawing is completed by utilizing the ultrasonic heat effect, so that the effect of rapid rewarming is achieved.
In other preferred embodiments, the acoustic transducer 3 is arranged in the space enclosed by the cutting head 2 in order to enable better ultrasound action on the tissue. And it can be understood that the sound wave emitted by the sound wave vibrator 3 is not limited to ultrasonic wave, and the sound wave with frequency lower than 20KHz can achieve corresponding effect.
Example two
The difference from the first embodiment is that: in this embodiment, as shown in fig. 2, one of the positive electrode and the negative electrode of the acoustic wave oscillator 3 is electrically connected to the distal end of the power transmission lead 9, and the other of the positive electrode and the negative electrode of the acoustic wave oscillator 3 is electrically connected to the tool bit 2 through a short lead, so that the tool bit does not need to pass through the mandrel 8, the lead can be thickened properly, a higher-power ultrasonic oscillator is used, and correspondingly, the positive electrode and the negative electrode of the acoustic wave generator 11 are electrically connected to the proximal end of the power transmission lead 9 and the tool body 2, respectively.
EXAMPLE III
The difference from the first embodiment is that: in this embodiment, the acoustic wave vibrator 3 is fixedly mounted on the outer side wall of the knife body 1. On one hand, the corresponding power transmission lead 9 can be laid along the outer side wall of the knife body 1 and is electrically connected with the sound generator 11; on the other hand, the power transmission lead 9 can also extend into the interior of the knife body 1 through a through hole formed in the side wall of the knife body 1, and then is electrically connected with the sound wave generator 11 after penetrating out through the mandrel 8. Preferably, the acoustic wave vibrator 3 is arranged to annularly cover the exterior of the knife body 1.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (10)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210049160.XA CN114246665A (en) | 2022-01-17 | 2022-01-17 | Sound wave-assisted cryoablation knife |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210049160.XA CN114246665A (en) | 2022-01-17 | 2022-01-17 | Sound wave-assisted cryoablation knife |
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| CN114246665A true CN114246665A (en) | 2022-03-29 |
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| CN202210049160.XA Pending CN114246665A (en) | 2022-01-17 | 2022-01-17 | Sound wave-assisted cryoablation knife |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116898559A (en) * | 2023-09-12 | 2023-10-20 | 首都医科大学附属北京友谊医院 | ablation scalpel |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139496A (en) * | 1990-12-20 | 1992-08-18 | Hed Aharon Z | Ultrasonic freeze ablation catheters and probes |
| US20090221955A1 (en) * | 2006-08-08 | 2009-09-03 | Bacoustics, Llc | Ablative ultrasonic-cryogenic methods |
| US20090306550A1 (en) * | 2008-06-04 | 2009-12-10 | Eilaz Babaev | Ultrasonic Endometrial Cryoablation Method |
| CN107714172A (en) * | 2017-11-10 | 2018-02-23 | 上海导向医疗系统有限公司 | Thermometric and the cryoablation pin of rewarming function are realized by thermocouple wire simultaneously |
| CN107997818A (en) * | 2017-11-10 | 2018-05-08 | 上海导向医疗系统有限公司 | The cryoablation pin of rewarming and thermotherapeutic function is realized by electric heating wire |
| CN218075190U (en) * | 2022-01-17 | 2022-12-20 | 上海理工大学 | A sonic-assisted cryoablation knife |
-
2022
- 2022-01-17 CN CN202210049160.XA patent/CN114246665A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139496A (en) * | 1990-12-20 | 1992-08-18 | Hed Aharon Z | Ultrasonic freeze ablation catheters and probes |
| US20090221955A1 (en) * | 2006-08-08 | 2009-09-03 | Bacoustics, Llc | Ablative ultrasonic-cryogenic methods |
| US20090306550A1 (en) * | 2008-06-04 | 2009-12-10 | Eilaz Babaev | Ultrasonic Endometrial Cryoablation Method |
| CN107714172A (en) * | 2017-11-10 | 2018-02-23 | 上海导向医疗系统有限公司 | Thermometric and the cryoablation pin of rewarming function are realized by thermocouple wire simultaneously |
| CN107997818A (en) * | 2017-11-10 | 2018-05-08 | 上海导向医疗系统有限公司 | The cryoablation pin of rewarming and thermotherapeutic function is realized by electric heating wire |
| CN218075190U (en) * | 2022-01-17 | 2022-12-20 | 上海理工大学 | A sonic-assisted cryoablation knife |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116898559A (en) * | 2023-09-12 | 2023-10-20 | 首都医科大学附属北京友谊医院 | ablation scalpel |
| CN116898559B (en) * | 2023-09-12 | 2023-12-19 | 首都医科大学附属北京友谊医院 | ablation scalpel |
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