CN114177246A - Height-increasing traditional Chinese medicine pellet and preparation method thereof - Google Patents
Height-increasing traditional Chinese medicine pellet and preparation method thereof Download PDFInfo
- Publication number
- CN114177246A CN114177246A CN202111323034.0A CN202111323034A CN114177246A CN 114177246 A CN114177246 A CN 114177246A CN 202111323034 A CN202111323034 A CN 202111323034A CN 114177246 A CN114177246 A CN 114177246A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- traditional chinese
- chinese medicine
- heightening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 111
- 239000008188 pellet Substances 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims description 17
- 229920000805 Polyaspartic acid Polymers 0.000 claims abstract description 52
- 229920006037 cross link polymer Polymers 0.000 claims abstract description 31
- 240000005373 Panax quinquefolius Species 0.000 claims abstract description 30
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 30
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 27
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 16
- 229920002472 Starch Polymers 0.000 claims abstract description 16
- 239000008101 lactose Substances 0.000 claims abstract description 16
- 210000002826 placenta Anatomy 0.000 claims abstract description 16
- 239000008107 starch Substances 0.000 claims abstract description 16
- 235000019698 starch Nutrition 0.000 claims abstract description 16
- 240000006766 Cornus mas Species 0.000 claims abstract description 15
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 15
- 241000405414 Rehmannia Species 0.000 claims abstract description 15
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 15
- 210000003056 antler Anatomy 0.000 claims abstract description 15
- 235000008434 ginseng Nutrition 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 14
- 241000427159 Achyranthes Species 0.000 claims abstract description 13
- 229940079593 drug Drugs 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 239000006187 pill Substances 0.000 claims description 45
- 238000000576 coating method Methods 0.000 claims description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 32
- 235000007215 black sesame Nutrition 0.000 claims description 32
- 239000011248 coating agent Substances 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 31
- 238000001035 drying Methods 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 21
- 108010064470 polyaspartate Proteins 0.000 claims description 19
- 210000003038 endothelium Anatomy 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 17
- 239000005711 Benzoic acid Substances 0.000 claims description 16
- 235000010233 benzoic acid Nutrition 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 14
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 14
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 14
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 14
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 14
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 14
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 14
- 240000000171 Crataegus monogyna Species 0.000 claims description 14
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 14
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 14
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 14
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 14
- 240000001008 Dimocarpus longan Species 0.000 claims description 14
- 235000002722 Dioscorea batatas Nutrition 0.000 claims description 14
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims description 14
- 240000001811 Dioscorea oppositifolia Species 0.000 claims description 14
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims description 14
- 235000000235 Euphoria longan Nutrition 0.000 claims description 14
- 108010010803 Gelatin Proteins 0.000 claims description 14
- 240000000950 Hippophae rhamnoides Species 0.000 claims description 14
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims description 14
- 240000000249 Morus alba Species 0.000 claims description 14
- 235000008708 Morus alba Nutrition 0.000 claims description 14
- 244000248557 Ophiopogon japonicus Species 0.000 claims description 14
- 239000007888 film coating Substances 0.000 claims description 14
- 238000009501 film coating Methods 0.000 claims description 14
- 229920000159 gelatin Polymers 0.000 claims description 14
- 239000008273 gelatin Substances 0.000 claims description 14
- 235000019322 gelatine Nutrition 0.000 claims description 14
- 235000011852 gelatine desserts Nutrition 0.000 claims description 14
- 239000011812 mixed powder Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- 229920001661 Chitosan Polymers 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 11
- 238000005507 spraying Methods 0.000 claims description 11
- 241000045403 Astragalus propinquus Species 0.000 claims description 10
- 241000007126 Codonopsis pilosula Species 0.000 claims description 10
- 235000006533 astragalus Nutrition 0.000 claims description 10
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 235000017784 Mespilus germanica Nutrition 0.000 claims description 8
- 244000182216 Mimusops elengi Species 0.000 claims description 8
- 235000000560 Mimusops elengi Nutrition 0.000 claims description 8
- 235000007837 Vangueria infausta Nutrition 0.000 claims description 8
- -1 drying Substances 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 8
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims description 7
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims description 7
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 238000000502 dialysis Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000005096 rolling process Methods 0.000 claims description 7
- 235000015468 Lycium chinense Nutrition 0.000 claims description 6
- 235000008422 Schisandra chinensis Nutrition 0.000 claims description 6
- 244000237330 gutta percha tree Species 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 244000197580 Poria cocos Species 0.000 claims description 5
- 235000008599 Poria cocos Nutrition 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
- 238000005360 mashing Methods 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 240000000031 Achyranthes bidentata Species 0.000 claims description 4
- 240000005856 Lyophyllum decastes Species 0.000 claims description 4
- 235000013194 Lyophyllum decastes Nutrition 0.000 claims description 4
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 3
- 238000000861 blow drying Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- 244000241838 Lycium barbarum Species 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 abstract description 15
- 241000208688 Eucommia Species 0.000 abstract description 9
- 239000000126 substance Substances 0.000 abstract description 8
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 6
- 241001116742 Drynaria Species 0.000 abstract description 5
- 230000012010 growth Effects 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 210000000988 bone and bone Anatomy 0.000 abstract description 4
- 235000015097 nutrients Nutrition 0.000 abstract description 4
- 150000001413 amino acids Chemical class 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 230000004060 metabolic process Effects 0.000 abstract description 2
- 230000035790 physiological processes and functions Effects 0.000 abstract description 2
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 2
- 239000011573 trace mineral Substances 0.000 abstract description 2
- 235000013619 trace mineral Nutrition 0.000 abstract description 2
- 239000011782 vitamin Substances 0.000 abstract description 2
- 235000013343 vitamin Nutrition 0.000 abstract description 2
- 229940088594 vitamin Drugs 0.000 abstract description 2
- 229930003231 vitamin Natural products 0.000 abstract description 2
- 239000009636 Huang Qi Substances 0.000 abstract 1
- 240000002948 Ophiopogon intermedius Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003826 tablet Substances 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- 244000241872 Lycium chinense Species 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 241000287828 Gallus gallus Species 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 229940107666 astragalus root Drugs 0.000 description 4
- 230000000975 bioactive effect Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 102000018997 Growth Hormone Human genes 0.000 description 3
- 108010051696 Growth Hormone Proteins 0.000 description 3
- 239000000122 growth hormone Substances 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 239000007941 film coated tablet Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000005243 fluidization Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 229940126673 western medicines Drugs 0.000 description 2
- 238000008157 ELISA kit Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000021332 multicellular organism growth Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a height-increasing traditional Chinese medicine pellet, which belongs to the technical field of traditional Chinese medicines, and the raw material medicines comprise the following traditional Chinese medicine components: ginseng, American ginseng, dogwood, pilose antler, Chinese magnoliavine fruit, eucommia bark, achyranthes root, dwarf lilyturf tuber, fortune's drynaria rhizome, pilose asiabell root, membranous milkvetch root, prepared rehmannia root and the like, wherein the pharmaceutic adjuvant comprises starch, lactose and chitosan-benzoic acid-polyaspartic acid cross-linked polymer; according to the heightening traditional Chinese medicine pellet, active ingredients of the achyranthes and the human placenta are extracted and then directly mixed with the rest crushed active ingredients to prepare the pellet, so that the heightening traditional Chinese medicine pellet is convenient to take, children can not generate rejection psychology when taking the heightening traditional Chinese medicine pellet, and the problem that the traditional Chinese medicine decoction is poor in taste is solved; the heightening traditional Chinese medicine pellet adopts medicinal and edible traditional Chinese medicinal materials, contains various nutrient substances required by human body heightening, such as protein, amino acid, vitamins and various trace elements, can provide nutrient substances for organisms, promote the metabolism of the organisms, regulate various physiological functions of physiological systems, enhance immunity, improve physique and promote the development and the growth of bones of the bodies after being taken consistently.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine micro-pill for increasing height and a preparation method thereof.
Background
The requirements of people in modern society on height are higher and higher, people with lower statures are not paid attention to the height, the height-adjustable pillow has no advantages in the aspects of working, studying, family establishment, social interaction and the like, the self character is influenced, and people often feel inferior. In the growth process of children, the height of the children is influenced by many factors, such as heredity, dietary nutrition, living environment and stress, which influence the growth speed of the children during growth and development and influence the final height of the children.
The adolescence is 10-16 years old, the golden time for the height of the child is the age of the child, and some people have the possibility of growing after the age of the child exceeds 20 years old, so that when the height of the child is obviously different from that of the same-age people, the child can be promoted to grow high through external conditioning. At present, the mode of assisting children in growing tall generally comprises western medicines and traditional Chinese medicines, but the heightened western medicines generally contain hormone components, so that the stimulation to the bodies of the children is large, the endocrine dyscrasia and the metabolic disorder of the bodies can be seriously caused, the traditional Chinese medicines are decocted into decoction, the taste is poor, the traditional Chinese medicines are inconvenient to take, the children are not easy to accept, the effect is slow, and the popularization of the heightened traditional Chinese medicines is influenced.
The quality of the traditional Chinese medicine auxiliary materials is not uniform, the traditional auxiliary materials are all used for matching the roundness range of the raw material medicines and the fluid performance of the plain pills, so that the pellets can be smoothly coated with a film, but the auxiliary materials also provide higher requirements for the slow release, the affinity and the load rate of the raw material medicines besides the basic functions as the requirements of people on the pellets are improved.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine micro-pill for increasing height and a preparation method thereof.
In order to achieve the purpose, the invention is realized by the following technical scheme:
the height-increasing traditional Chinese medicine pellet comprises starch, lactose and a chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 1-3: 1-4: 1, preparing a composition;
the chitosan-benzoic acid-polyaspartic acid cross-linked polymer is prepared by the following steps:
taking 12-18 parts by weight of benzoic acid and 8-10 parts by weight of polyaspartic acid, adding the benzoic acid and the polyaspartic acid into 100-120 parts by weight of dimethyl sulfoxide, adding 20-45 parts by weight of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride and 15-50 parts by weight of N-hydroxysuccinimide under stirring, stirring and reacting for 1-5 hours at 10-30 ℃, adding 50-60 parts by weight of chitosan, heating to 50-70 ℃, stirring and reacting for 12-15 hours, dialyzing with a dialysis bag with the molecular weight of 3500, and freeze-drying to obtain the chitosan-benzoic acid-polyaspartic acid cross-linked polymer.
Preferably, the bulk drugs of the heightening traditional Chinese medicine pellet comprise the following raw materials in parts by weight: 6-10 parts of ginseng, 3-6 parts of American ginseng, 6-10 parts of dogwood, 1-3 parts of pilose antler, 6-10 parts of schisandra chinensis, 10-15 parts of eucommia ulmoides, 6-10 parts of achyranthes bidentata, 6-10 parts of ophiopogon japonicus, 6-15 parts of rhizoma drynariae, 6-10 parts of codonopsis pilosula, 6-15 parts of astragalus membranaceus, 6-10 parts of prepared rehmannia root, 6-10 parts of mulberry, 6-10 parts of wolfberry, 3-10 parts of endothelium corneum gigeriae galli, 3-10 parts of hawthorn, 3-15 parts of Chinese yam, 6-10 parts of longan pulp, 6-10 parts of donkey-hide gelatin, 6-10 parts of poria, 3-6 parts of sea buckthorn, 6-10 parts of black sesame and 6-15 parts of human placenta; the heightening traditional Chinese medicine pellet contains 120-150 parts of pharmaceutical excipients.
Preferably, the pharmaceutical excipients are prepared from starch, lactose and chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 2: 3: 1.
The invention also comprises a preparation method of the heightening traditional Chinese medicine pellet, which comprises the following steps:
firstly, stir-frying the black sesame by a stir-frying method until the black sesame is exploded, and cooling to obtain stir-fried black sesame for later use;
secondly, frying the cleaned endothelium corneum gigeriae galli with slow fire until the surface color is deepened to obtain fried endothelium corneum gigeriae galli for later use;
thirdly, 6-10 parts by weight of ginseng to be dried, 3-6 parts by weight of American ginseng, 6-10 parts by weight of dogwood, 1-3 parts by weight of pilose antler, 6-10 parts by weight of schisandra chinensis, 10-15 parts by weight of eucommia ulmoides, 6-10 parts by weight of ophiopogon japonicus, 6-15 parts by weight of rhizoma drynariae, 6-10 parts by weight of codonopsis pilosula, 6-15 parts by weight of astragalus membranaceus, 6-10 parts by weight of prepared rehmannia root, 6-10 parts by weight of mulberry, 6-10 parts by weight of medlar, 3-10 parts by weight of hawthorn, 3-15 parts by weight of Chinese yam, 6-10 parts by weight of dried longan pulp, 6-10 parts by weight of donkey-hide gelatin, 6-10 parts by weight of poria cocos, 3-6 parts by weight of sea-buckthorn, 6-10 parts by weight of cooked black sesame obtained in the first step and 3-10 parts by weight of fried chicken's gizzard-membrane obtained in the step are added into a mashing machine to be crushed and ground to 100-200 meshes to obtain mixed powder for later use;
mixing and crushing 6-10 parts of achyranthes and 6-15 parts of human placenta to 20-50 meshes, adding water with the mass being 5-10 times of that of the mixture, boiling and extracting for 15-20 minutes, filtering, concentrating the filtrate, and drying to obtain dry extract powder;
fifthly, uniformly mixing the mixed powder obtained in the third step, the dry extract powder obtained in the fourth step and 120-150 parts of pharmaceutical excipients to obtain a traditional Chinese medicine mixture, preparing plain pills with the diameter of 2-3 mm by water, drying, and coating with a film coat to obtain the heightening traditional Chinese medicine pellets.
Preferably, in the fifth step, the film coating solution used in the film coating is composed of 4 to 8 parts by weight of hydroxypropyl methylcellulose, 0.1 to 0.5 part by weight of pore-forming agent polyethylene glycol, 0.1 to 0.3 part by weight of plasticizer glycerol and 100 parts by weight of water.
Preferably, the step of preparing the vegetarian meat balls with the diameter of 2-3 mm by water comprises the following steps:
granulating the traditional Chinese medicine mixture, granulating the prepared granules with a 25-mesh sieve, rolling the granules in a coating pan, spraying water in sequence, scattering the rest traditional Chinese medicine mixture, blow-drying, repeating the operation, and sieving to obtain pellets with the diameter of 2-3 mm.
Preferably, in the fifth step, the process parameters of the film coating are as follows: the flow rate is 0.1-0.12 kg/min, and the pressure is 0.2-0.3 MPa; the drying temperature is 40-50 ℃.
Compared with the prior art, the invention has the following advantages:
the heightening traditional Chinese medicine pellet adopts starch, lactose and a chitosan-benzoic acid-polyaspartic acid cross-linked polymer as auxiliary materials, wherein the chitosan-benzoic acid-polyaspartic acid cross-linked polymer takes polyaspartic acid as a cross-linking agent to prepare cross-linked chitosan, on one hand, the polyaspartic acid contains a large amount of carboxyl groups and can be condensed with amino groups in chitosan to form a compact net structure so as to further wrap bioactive substances in a traditional Chinese medicine extract; on the other hand, carboxyl in benzoic acid reacts with partial amino in chitosan, and aromatic groups are introduced into the drug carrier, so that the chitosan-polyaspartic acid molecule has a hydrophobic structure, has better affinity to aromatic active substances in the traditional Chinese medicine extract, and has higher drug loading rate.
The heightening traditional Chinese medicine pellet adopts medicinal and edible traditional Chinese medicinal materials, contains various nutrient substances required by human body heightening, such as protein, amino acid, vitamins and various trace elements, can provide nutrient substances for organisms, promote the metabolism of the organisms, regulate various physiological functions of physiological systems, enhance immunity, and can improve physique and promote the development and the growth of bones of the bodies after being taken; the heightening traditional Chinese medicine pellet provided by the invention does not generate the problem of endocrine disturbance caused by western medicine heightening hormone, is safe and reliable, has no toxic or side effect, and can be taken for a long time.
According to the preparation method of the heightening traditional Chinese medicine micro-pill, active ingredients of the achyranthes and the human placenta are extracted and then directly mixed with the rest crushed active ingredients to prepare the micro-pill, so that the heightening traditional Chinese medicine micro-pill is convenient to take, children can not reject psychology when taking the heightening traditional Chinese medicine micro-pill, and the problem that the traditional Chinese medicine decoction is poor in taste is solved.
Detailed Description
The invention aims to provide a traditional Chinese medicine pellet for increasing height and a preparation method thereof, and the traditional Chinese medicine pellet is realized by the following technical scheme:
the height-increasing traditional Chinese medicine pellet comprises starch, lactose and a chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 1-3: 1-4: 1, preparing a composition;
the chitosan-benzoic acid-polyaspartic acid cross-linked polymer is prepared by the following steps:
taking 12-18 parts by weight of benzoic acid and 8-10 parts by weight of polyaspartic acid, adding the benzoic acid and the polyaspartic acid into 100-120 parts by weight of dimethyl sulfoxide, adding 20-45 parts by weight of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride and 15-50 parts by weight of N-hydroxysuccinimide under stirring, stirring and reacting for 1-5 hours at 10-30 ℃, adding 50-60 parts by weight of chitosan, heating to 50-70 ℃, stirring and reacting for 12-15 hours, dialyzing with a dialysis bag with the molecular weight of 3500, and freeze-drying to obtain the chitosan-benzoic acid-polyaspartic acid cross-linked polymer.
According to the chitosan-benzoic acid-polyaspartic acid cross-linked polymer as the auxiliary material, polyaspartic acid is used as a cross-linking agent to prepare cross-linked chitosan, on one hand, polyaspartic acid contains a large amount of carboxyl and can be condensed with amino in chitosan to form a compact net structure so as to wrap bioactive substances in a traditional Chinese medicine extract, and the polyaspartic acid contains a large amount of carbonyl and amido bonds, so that the bioactive substances in the traditional Chinese medicine extract can be combined through the action of hydrogen bonds, the bioactive substances are slowly released, and the slow release effect is achieved; on the other hand, carboxyl in benzoic acid reacts with partial amino in chitosan, and aromatic groups are introduced into the drug carrier, so that the chitosan-polyaspartic acid molecule has a hydrophobic structure, has better affinity to aromatic active substances in the traditional Chinese medicine extract, and has higher drug loading rate.
Preferably, the bulk drugs of the heightening traditional Chinese medicine pellet comprise the following raw materials in parts by weight: 6-10 parts of ginseng, 3-6 parts of American ginseng, 6-10 parts of dogwood, 1-3 parts of pilose antler, 6-10 parts of schisandra chinensis, 10-15 parts of eucommia ulmoides, 6-10 parts of achyranthes bidentata, 6-10 parts of ophiopogon japonicus, 6-15 parts of rhizoma drynariae, 6-10 parts of codonopsis pilosula, 6-15 parts of astragalus membranaceus, 6-10 parts of prepared rehmannia root, 6-10 parts of mulberry, 6-10 parts of wolfberry, 3-10 parts of endothelium corneum gigeriae galli, 3-10 parts of hawthorn, 3-15 parts of Chinese yam, 6-10 parts of longan pulp, 6-10 parts of donkey-hide gelatin, 6-10 parts of poria, 3-6 parts of sea buckthorn, 6-10 parts of black sesame and 6-15 parts of human placenta; the heightening traditional Chinese medicine pellet contains 120-150 parts of pharmaceutical excipients.
The roundness range of the compound pharmaceutic adjuvant adopted by the invention is 0.92-0.97, while the roundness of the starch and the lactose which are adopted independently in the test is 0.80-0.83 and 0.82-0.85 respectively, so that the starch and the lactose are difficult to round and are mostly in the shape of short bars, therefore, the starch, the lactose and the chitosan-benzoic acid-polyaspartic acid cross-linked polymer are selected according to the mass ratio of 1-3: 1-4: 1 to obtain the compound pharmaceutic adjuvant.
Preferably, the pharmaceutical excipients are prepared from starch, lactose and chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 2: 3: 1, the preferable pharmaceutic adjuvant can control the roundness of the pellet to be more than 0.95, and has better roundness of the pellet.
The invention also comprises a preparation method of the heightening traditional Chinese medicine pellet, which comprises the following steps:
firstly, stir-frying the black sesame by a stir-frying method until the black sesame is exploded, and cooling to obtain stir-fried black sesame for later use;
secondly, frying the cleaned endothelium corneum gigeriae galli with slow fire until the surface color is deepened to obtain fried endothelium corneum gigeriae galli for later use;
thirdly, 6-10 parts by weight of ginseng to be dried, 3-6 parts by weight of American ginseng, 6-10 parts by weight of dogwood, 1-3 parts by weight of pilose antler, 6-10 parts by weight of schisandra chinensis, 10-15 parts by weight of eucommia ulmoides, 6-10 parts by weight of ophiopogon japonicus, 6-15 parts by weight of rhizoma drynariae, 6-10 parts by weight of codonopsis pilosula, 6-15 parts by weight of astragalus membranaceus, 6-10 parts by weight of prepared rehmannia root, 6-10 parts by weight of mulberry, 6-10 parts by weight of medlar, 3-10 parts by weight of hawthorn, 3-15 parts by weight of Chinese yam, 6-10 parts by weight of dried longan pulp, 6-10 parts by weight of donkey-hide gelatin, 6-10 parts by weight of poria cocos, 3-6 parts by weight of sea-buckthorn, 6-10 parts by weight of cooked black sesame obtained in the first step and 3-10 parts by weight of fried chicken's gizzard-membrane obtained in the step are added into a mashing machine to be crushed and ground to 100-200 meshes to obtain mixed powder for later use;
mixing and crushing 6-10 parts of achyranthes and 6-15 parts of human placenta to 20-50 meshes, adding water with the mass being 5-10 times of that of the mixture, boiling and extracting for 15-20 minutes, filtering, concentrating the filtrate, and drying to obtain dry extract powder;
fifthly, uniformly mixing the mixed powder obtained in the third step, the dry extract powder obtained in the fourth step and 120-150 parts of pharmaceutical excipients to obtain a traditional Chinese medicine mixture, preparing plain pills with the diameter of 2-3 mm by water, drying, and coating with a film coat to obtain the heightening traditional Chinese medicine pellets.
In the process of coating and fluidizing the pellets, materials on the surfaces of the pellets are likely to be broken and peeled off in the process of impact due to impact between the plain pellets and a coating pan, so that the loss of the materials is caused, the pellets are required to have certain hardness, the plain pellets m1g are accurately weighed and placed into a rolling cylinder of a friability meter, the rolling cylinder is rotated 100 times at a set rotating speed of 25r/min, after the rotation is finished, the pellets are taken out and pass through a 24-mesh sieve, the mass of the rest pellets is m2g, the parallel test is carried out for 3 times each time, and the friability is (m1-m2)/m1 × 100%;
in the fluidized bed coating process, the bulk density is different from the process conditions required to achieve the desired fluidization state, and therefore the bulk density of the vegetarian pellets needs to be tested.
The angle of repose is also an important index of the properties of the granular fluid, and it is generally considered that the fluidity of the granules is relatively good when the angle of repose is 30 ° or less.
The results of tests on the friability, the bulk density and the angle of repose of the plain pills prepared by water show that the friability, the bulk density and the angle of repose of the plain pills obtained by adopting the proportion of the raw materials and the pharmaceutical excipients and the preparation process are below 0.60, the bulk density is 0.60-0.65 g/ml, the angle of repose is 26-28 degrees, and the roundness range is 0.91-0.95, so that the plain pills have good roundness, proper friability and bulk density and good particle flowability, and can be subjected to the next coating operation.
Preferably, in the fifth step, the film coating solution used in the film coating is composed of 4 to 8 parts by weight of hydroxypropyl methylcellulose, 0.1 to 0.5 part by weight of pore-forming agent polyethylene glycol, 0.1 to 0.3 part by weight of plasticizer glycerol and 100 parts by weight of water, and the technological parameters of the film coating are as follows: the flow rate is 0.1-0.12 kg/min, and the pressure is 0.2-0.3 MPa; the drying temperature is 40-50 ℃;
the concentration of the film coating liquid is scientific and reasonable, the problems that the coating liquid cannot be dried completely in a short time due to overlarge concentration of the polymer and the coating efficiency is low are solved, and the problems that the concentration is too low, the volume of the coating liquid is large and the coating time is long are solved; the optimized coating process parameters have good fluidization state in the coating process, and the pellets are not adhered.
Preferably, the step of preparing the vegetarian meat balls with the diameter of 2-3 mm by water comprises the following steps:
granulating the traditional Chinese medicine mixture, granulating the prepared granules with a 25-mesh sieve, rolling the granules in a coating pan, spraying water in sequence, scattering the rest traditional Chinese medicine mixture, blow-drying, repeating the operation, and sieving to obtain pellets with the diameter of 2-3 mm.
The invention also comprises a method for taking the heightening traditional Chinese medicine micro-pill, which is taken twice a day with 10-20 pills each time by warm boiled water.
The invention is further described with reference to specific examples.
Example 1
A traditional Chinese medicine pellet for increasing height is composed of the following raw material medicines: 6g of ginseng, 3g of American ginseng, 6g of dogwood, 1g of pilose antler, 6g of Chinese magnoliavine fruit, 10g of eucommia bark, 6g of achyranthes root, 6g of dwarf lilyturf tuber, 6g of fortune's drynaria rhizome, 6g of pilose asiabell root, 6g of astragalus root, 6g of prepared rehmannia root, 6g of mulberry, 6g of Chinese wolfberry, 3g of chicken's gizzard-membrane, 3g of hawthorn fruit, 3g of Chinese yam, 6g of longan pulp, 6g of donkey-hide gelatin, 6g of poria, 3g of sea-buckthorn, 6g of black sesame and 6g of human placenta; the heightening traditional Chinese medicine micro-pill also contains 120g of pharmaceutic adjuvant;
the pharmaceutical excipients are prepared from starch, lactose and chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 1: 1: 1, preparing a composition;
the chitosan-benzoic acid-polyaspartic acid cross-linked polymer is prepared by the following steps:
taking 12 parts by weight of benzoic acid and 8 parts by weight of polyaspartic acid, adding the benzoic acid and the polyaspartic acid into 100 parts by weight of dimethyl sulfoxide, adding 20 parts by weight of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride and 15 parts by weight of N-hydroxysuccinimide under stirring, stirring and reacting for 1 hour at 10 ℃, adding 50 parts by weight of chitosan, heating to 50 ℃, stirring and reacting for 12 hours, dialyzing by using a dialysis bag with the molecular weight of 3500, and freeze-drying to obtain the chitosan-benzoic acid-polyaspartic acid cross-linked polymer.
Example 2
A traditional Chinese medicine pellet for increasing height is composed of the following raw material medicines: 10g of ginseng, 6g of American ginseng, 10g of dogwood, 3g of pilose antler, 10g of Chinese magnoliavine fruit, 15g of eucommia bark, 10g of achyranthes root, 10g of dwarf lilyturf tuber, 15g of fortune's drynaria rhizome, 10g of pilose asiabell root, 15g of astragalus root, 10g of prepared rehmannia root, 10g of mulberry, 10g of medlar, 10g of chicken's gizzard-membrane, 10g of hawthorn fruit, 15g of Chinese yam, 10g of longan pulp, 10g of donkey-hide gelatin, 10g of poria, 6g of sea-buckthorn, 10g of black sesame and 15g of human placenta; the heightening traditional Chinese medicine micro-pill also contains 150g of pharmaceutic adjuvant;
the pharmaceutical excipients are prepared from starch, lactose and chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to the mass ratio of 3: 4: 1, preparing a composition;
the chitosan-benzoic acid-polyaspartic acid cross-linked polymer is prepared by the following steps:
taking 18 parts by weight of benzoic acid and 10 parts by weight of polyaspartic acid, adding the benzoic acid and the polyaspartic acid into 120 parts by weight of dimethyl sulfoxide, adding 45 parts by weight of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride and 50 parts by weight of N-hydroxysuccinimide under stirring, stirring and reacting for 5 hours at the temperature of 30 ℃, adding 60 parts by weight of chitosan, heating to 70 ℃, stirring and reacting for 15 hours, dialyzing by using a dialysis bag with the molecular weight of 3500, and freeze-drying to obtain the chitosan-benzoic acid-polyaspartic acid cross-linked polymer.
Example 3
A traditional Chinese medicine pellet for increasing height is composed of the following raw material medicines: : 8g of ginseng, 5g of American ginseng, 7g of dogwood, 2g of pilose antler, 8g of Chinese magnoliavine fruit, 12g of eucommia, 9g of achyranthes root, 8g of dwarf lilyturf root, 9g of fortune's drynaria rhizome, 9g of pilose asiabell root, 8g of astragalus root, 8g of prepared rehmannia root, 7g of mulberry, 7g of medlar, 5g of chicken's gizzard-membrane, 4g of hawthorn fruit, 12g of Chinese yam, 8g of longan pulp, 9g of donkey-hide gelatin, 7g of poria, 4g of sea-buckthorn, 7g of black sesame and 8g of human placenta; the heightening traditional Chinese medicine pellet also contains 140g of pharmaceutic adjuvant;
the pharmaceutical excipients are prepared from starch, lactose and chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 2: 2: 1, preparing a composition;
the chitosan-benzoic acid-polyaspartic acid cross-linked polymer is prepared by the following steps:
taking 15 parts by weight of benzoic acid and 9 parts by weight of polyaspartic acid, adding the benzoic acid and the polyaspartic acid into 105 parts by weight of dimethyl sulfoxide, adding 30 parts by weight of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride and 20 parts by weight of N-hydroxysuccinimide under stirring, stirring and reacting for 2 hours at 20 ℃, adding 54 parts by weight of chitosan, heating to 55 ℃, stirring and reacting for 14 hours, dialyzing by using a dialysis bag with the molecular weight of 3500, and freeze-drying to obtain the chitosan-benzoic acid-polyaspartic acid cross-linked polymer.
Example 4
A traditional Chinese medicine pellet for increasing height is composed of the following raw material medicines: : 9g of ginseng, 4g of American ginseng, 8g of dogwood, 5g of pilose antler, 7g of Chinese magnoliavine fruit, 14g of eucommia, 7g of achyranthes root, 7g of dwarf lilyturf root, 12g of fortune's drynaria rhizome, 7g of pilose asiabell root, 12g of astragalus root, 9g of prepared rehmannia root, 8g of mulberry, 8g of Chinese wolfberry, 8g of chicken's gizzard-membrane, 8g of hawthorn fruit, 6g of Chinese yam, 9g of longan pulp, 8g of donkey-hide gelatin, 9g of poria, 5g of sea-buckthorn, 9g of black sesame and 12g of human placenta; the heightening traditional Chinese medicine micro-pill also contains 125g of pharmaceutic adjuvant;
the pharmaceutical excipients are prepared from starch, lactose and chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 2: 3: 1, preparing a composition;
the preparation method of the chitosan-benzoic acid-polyaspartic acid cross-linked polymer is the same as that of example 3.
Example 5
The preparation method of the heightening traditional Chinese medicine pellet described in example 1 comprises the following steps:
firstly, stir-frying the black sesame by a stir-frying method until the black sesame is exploded, and cooling to obtain stir-fried black sesame for later use;
secondly, frying the cleaned endothelium corneum gigeriae galli with slow fire until the surface color is deepened to obtain fried endothelium corneum gigeriae galli for later use;
③ adding 6g of dried ginseng, 3g of American ginseng, 6g of dogwood, 1g of pilose antler, 6g of Chinese magnoliavine fruit, 10g of eucommia bark, 6g of dwarf lilyturf tuber, 6g of rhizoma drynariae, 6g of codonopsis pilosula, 6g of astragalus mongholicus, 6g of prepared rehmannia root, 6g of mulberry, 6g of medlar, 3g of hawthorn, 3g of Chinese yam, 6g of longan aril, 6g of donkey-hide gelatin, 6g of poria cocos and 3g of sea buckthorn, crushing the cooked black sesame obtained in the step I and the fried chicken's gizzard-membrane obtained in the step II in a crusher, and grinding the materials to 100 meshes to obtain mixed powder for later use;
mixing and crushing 6g of achyranthes root and 6g of human placenta to 20-50 meshes, adding water with the mass being 5 times of that of the mixture, boiling and extracting for 15 minutes, filtering, concentrating the filtrate, and drying to obtain dry extract powder;
fifthly, uniformly mixing the mixed powder obtained in the third step, the dry extract powder obtained in the fourth step and 120g of pharmaceutic adjuvant to obtain a traditional Chinese medicine mixture, preparing plain pills with the diameter of 2-3 mm by water, drying, and coating with a film coat to obtain the heightening traditional Chinese medicine pellets.
Example 6
The preparation method of the heightening traditional Chinese medicine pellet described in example 2 comprises the following steps:
firstly, stir-frying the black sesame by a stir-frying method until the black sesame is exploded, and cooling to obtain stir-fried black sesame for later use;
secondly, frying the cleaned endothelium corneum gigeriae galli with slow fire until the surface color is deepened to obtain fried endothelium corneum gigeriae galli for later use;
③ adding 10g of dried ginseng, 6g of American ginseng, 10g of dogwood, 3g of pilose antler, 10g of Chinese magnoliavine fruit, 15g of eucommia bark, 10g of dwarf lilyturf tuber, 15g of rhizoma drynariae, 10g of codonopsis pilosula, 15g of astragalus mongholicus, 10g of prepared rehmannia root, 10g of mulberry fruit, 10g of medlar, 10g of hawthorn fruit, 15g of Chinese yam, 10g of longan pulp, 10g of donkey-hide gelatin, 10g of poria cocos and 6g of sea-buckthorn to a mashing machine for crushing and grinding the materials to 100-200 meshes to obtain mixed powder for later use;
mixing 10g of achyranthes root and 15g of human placenta, crushing to 20-50 meshes, adding 10 times of water, boiling and extracting for 20 minutes, filtering, concentrating the filtrate, and drying to obtain dry extract powder;
fifthly, uniformly mixing the mixed powder obtained in the third step, the dry extract powder obtained in the fourth step and 150g of pharmaceutical excipients to obtain a traditional Chinese medicine mixture, preparing plain pills with the diameter of 2-3 mm by water, drying, and coating with a film coat to obtain the heightening traditional Chinese medicine pellets.
Example 7
The preparation method of the heightening traditional Chinese medicine pellet comprises the following steps:
firstly, stir-frying the black sesame by a stir-frying method until the black sesame is exploded, and cooling to obtain stir-fried black sesame for later use;
secondly, frying the cleaned endothelium corneum gigeriae galli with slow fire until the surface color is deepened to obtain fried endothelium corneum gigeriae galli for later use;
③ adding 8g of prepared dried ginseng, 5g of American ginseng, 7g of dogwood, 2g of pilose antler, 8g of Chinese magnoliavine fruit, 12g of eucommia bark, 8g of dwarf lilyturf root, 9g of rhizoma drynariae, 9g of codonopsis pilosula, 8g of astragalus mongholicus, 8g of prepared rehmannia root, 7g of mulberry, 7g of medlar, 4g of hawthorn, 12g of Chinese yam, 8g of longan aril, 9g of donkey-hide gelatin, 7g of poria and 4g of sea buckthorn into a pounding machine for crushing and grinding to 100-200 meshes to obtain mixed powder for later use;
mixing and crushing 9g of achyranthes bidentata and 8g of human placenta to 20-50 meshes, adding water with the mass being 6 times of that of the mixture, boiling and extracting for 18 minutes, filtering, concentrating the filtrate, and drying to obtain dry extract powder;
fifthly, uniformly mixing the mixed powder obtained in the third step, the dry extract powder obtained in the fourth step and 140g of pharmaceutic adjuvant to obtain a traditional Chinese medicine mixture, preparing plain pills with the diameter of 2-3 mm by water, drying, and coating a film coat to obtain the heightening traditional Chinese medicine micro-pills;
wherein the step of preparing plain pills with the diameter of 2-3 mm by water comprises the following steps:
granulating the traditional Chinese medicine mixture, finishing the prepared granules with a 25-mesh sieve, rolling the granules in a coating pan, spraying water in sequence, scattering the rest traditional Chinese medicine mixture, drying, repeating the operation, and sieving to obtain pellets with the diameter of 2-3 mm;
the specific steps of coating the film coat are as follows:
preparing a film coating solution used in coating a film coat, wherein the film coating solution comprises 4 parts by weight of hydroxypropyl methyl cellulose, 0.1 part by weight of polyethylene glycol, 0.1 part by weight of glycerol and 100 parts by weight of water;
preheating a coating pan to 35 ℃, placing the watered pill in the coating pan, starting the coating pan to heat the tablet uniformly, starting a compression pump to 0.2MPa, spraying the prepared coating liquid on the surface of the rotating tablet by a spray gun with the flow rate of 0.12kg/min, drying by hot air at 50 ℃, continuously spraying for about 40 minutes until the tablet surface is complete, smooth and clean and the color is uniform, stopping spraying liquid, and drying by cold air to obtain the heightened traditional Chinese medicine pellet.
Example 8
The preparation method of the heightening traditional Chinese medicine pellet comprises the following steps:
firstly, stir-frying the black sesame by a stir-frying method until the black sesame is exploded, and cooling to obtain stir-fried black sesame for later use;
secondly, frying the cleaned endothelium corneum gigeriae galli with slow fire until the surface color is deepened to obtain fried endothelium corneum gigeriae galli for later use;
③ adding 9g of dried ginseng, 4g of American ginseng, 8g of dogwood, 5g of pilose antler, 7g of Chinese magnoliavine fruit, 14g of eucommia bark, 7g of dwarf lilyturf tuber, 12g of rhizoma drynariae, 7g of codonopsis pilosula, 12g of astragalus mongholicus, 9g of prepared rehmannia root, 8g of mulberry, 8g of Chinese wolfberry, 8g of hawthorn, 6g of Chinese yam, 9g of longan pulp, 8g of donkey-hide gelatin, 9g of poria and 5g of sea-buckthorn to a mashing machine, crushing and grinding the materials to 100-200 meshes to obtain mixed powder for later use;
mixing 7g of achyranthes and 12g of human placenta, crushing to 20-50 meshes, adding water with the mass being 8 times of that of the mixture, boiling and extracting for 18 minutes, filtering, concentrating the filtrate, and drying to obtain dry extract powder;
fifthly, uniformly mixing the mixed powder obtained in the third step, the dry extract powder obtained in the fourth step and 125g of pharmaceutical excipients to obtain a traditional Chinese medicine mixture, preparing plain pills with the diameter of 2-3 mm by water, drying, and coating a film coat to obtain the heightening traditional Chinese medicine micro-pills;
wherein the step of preparing plain pills with the diameter of 2-3 mm by water comprises the following steps:
granulating the traditional Chinese medicine mixture, finishing the prepared granules with a 25-mesh sieve, rolling the granules in a coating pan, spraying water in sequence, scattering the rest traditional Chinese medicine mixture, drying, repeating the operation, and sieving to obtain pellets with the diameter of 2-3 mm;
the specific steps of coating the film coat are as follows:
preparing a film coating solution used in coating a film coat, wherein the film coating solution comprises 8 parts by weight of hydroxypropyl methyl cellulose, 0.5 part by weight of polyethylene glycol, 0.3 part by weight of glycerol and 100 parts by weight of water;
preheating a coating pan to 35 ℃, placing the watered pill in the coating pan, starting the coating pan to heat the tablet uniformly, starting a compression pump to 0.3MPa, spraying the prepared coating liquid on the surface of the rotating tablet by a spray gun with the flow rate of 0.1kg/min, drying by hot air at 40 ℃, continuously spraying for about 40 minutes until the tablet surface is complete, smooth and clean and the color is uniform, stopping spraying liquid, and drying by cold air to obtain the heightened traditional Chinese medicine pellet.
The heightening traditional Chinese medicine micro-pills in the above embodiments are 1 g/pill, and the taking method is to take the heightening traditional Chinese medicine micro-pills with warm boiled water twice a day, and 6-10 pills once. Three months is a treatment course, and 2-4 treatment courses are generally needed.
The heightening traditional Chinese medicine pellets obtained in examples 5-8 are tested for the body-growth promoting effect, animals are selected to be SD rats, the animal raising environment temperature is 20-24 ℃, the humidity is 50-70%, 12 light and shade alternate, and the illumination is 7: 00-12: 00 and noise less than 50 dB.
The experimental process comprises the following steps: 25 SD rats in the same period are selected, the original body length is not statistically poor and is randomly divided into 5 groups, namely the experimental group of examples 5-8 and the blank group, the SD rats in the experimental group of examples 5-8 are respectively gavaged with the heightened traditional Chinese medicine pellets obtained in the examples 5-8 according to the weight of 0.35mg/g, the blank group is gavaged with purified water, the rest feeding conditions are consistent, animals are respectively anesthetized on the 25 th day of gavage, the body length of the rats (the joint between the topmost head and the tail of the hip) is measured by using a ruler and is accurate to 1mm, the average value of each group is calculated, statistical treatment is carried out by using statistical software, data is analyzed by variance of completely randomly designed data, the difference has statistical significance when P is less than 0.05, and the result has significant statistical significance when P is less than 0.01, as shown in Table 1.
TABLE 1 Effect of height increasing Chinese medicinal pellet on rat body length
| Group of | Body length/cm after gastric lavage for 20 days |
| Example 5 Experimental group | 9.0±0.4① |
| Example 6 Experimental group | 9.1±0.5① |
| Example 7 Experimental group | 9.3±0.3② |
| Example 8 Experimental group | 9.4±0.4② |
| Blank group | 7.5±0.2 |
Note: in comparison with the blank set, the results,①P＜0.05，②P＜0.01。
measuring the content of growth hormone in the blood of the mouse, respectively anesthetizing the animal on the 20 th day of gastric lavage, taking blood and killing the animal, naturally coagulating the blood for 20min at room temperature, centrifuging the blood for 20min at the centrifugal radius of 3000r/min, collecting supernatant, and measuring the GH level by using an ELISA kit, wherein the results are shown in Table 2.
TABLE 2 Effect of increasing amounts of Chinese medicinal pellets on rat serum growth hormone content
| Group of | GH content/ng/mL after 20 days of intragastric administration |
| Example 5 Experimental group | 98.45±10.14 |
| Example 6 Experimental group | 98.85±14.52① |
| Example 7 Experimental group | 99.36±12.35② |
| Example 8 Experimental group | 99.42±15.24② |
| Blank group | 40.12±12.45 |
Note: in comparison with the blank set, the results,①P＜0.05，②P＜0.01。
as can be seen from tables 1 and 2, the traditional Chinese medicine micro-pill for increasing height can obviously improve the secretion of growth hormone, and finally leads to the increase of the height of a rat. In addition, because the film-coated tablets are adopted in the embodiments 3-4, the moisture resistance and the taste masking can be realized, the mildewing is not easy, the disintegration is easy, the dissolution rate, the bioavailability and the effective period of the medicine are greatly improved, and the effect is excellent when the film-coated tablets are matched with the components.
The clinical observation and treatment of 200 children, each person is increased by more than 15 cm per year, the maximum is increased by 25 cm, and more than 95 percent of children exceed the average height of parents. Moreover, the heightening traditional Chinese medicine pellet disclosed by the invention is matched with 1-2 hours of movement every day, so that the effect is more obvious.
The following are typical cases.
Plum, 11 years old, male, 158.2 cm high, go to hospital and take a tablet to measure bone age, predict height about 170 cm, take the heightening traditional Chinese medicine micro-pill of the invention example 7 twice a day, 10 pills once, take a year long and 15 cm high, parents react with appetite enhancement of children, do not eat food, symptom of sweating of deficiency in the evening disappears, go to toilet 3-4 times in the evening before, at present, do not use toilet basically at night, sleep is improved obviously, continue to take for half a year, long and 8 cm high, effect is obvious.
The height of the children is 162cm, the character is inward, the learning pressure is high, the sleep is poor, and the children are easy to dreams when taking the heightening traditional Chinese medicine micro-pill of the embodiment 8 of the invention, the traditional Chinese medicine micro-pill is taken twice a day, 8 pills are taken once, the period is 3 months, the height is 8 cm, the sleep condition is obviously improved, the dreams at night are obviously improved, the attention in the daytime is focused, the children like to discuss the problems in life and learning with parents at present, the children continue to take the traditional Chinese medicine micro-pill for half a month, the children grow 6 cm, and the heights and the spiritual appearances of the children are greatly improved.
In Sunzhi, 14 years old, male, 173.2 cm, go to hospital and take a tablet to measure the bone age, the epiphyseal line is close to closed, the expected length can be 3-4 cm, and the maximum length can be 177.5 cm, 10 pills are taken twice a day after taking the heightening traditional Chinese medicine pellet disclosed by the embodiment 7 of the invention, the length of one year is 5.1 cm, the epiphyseal line is close to closed, the expected length can be about 1-2 cm after taking the heightening traditional Chinese medicine pellet disclosed by the invention again, the height is higher than the predicted height of the initial hospital at present, the traditional Chinese medicine pellet can grow, the heightening traditional Chinese medicine pellet disclosed by the embodiment 7 of the invention is continuously taken for 9 months, and the return visit height reaches 181.0 cm.
Claims (7)
1. A traditional Chinese medicine micro pill for increasing height is characterized in that: the pharmaceutical composition is prepared from raw material medicines and pharmaceutical excipients, wherein the pharmaceutical excipients are prepared from starch, lactose and chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 1-3: 1-4: 1, preparing a composition;
the chitosan-benzoic acid-polyaspartic acid cross-linked polymer is prepared by the following steps:
taking 12-18 parts by weight of benzoic acid and 8-10 parts by weight of polyaspartic acid, adding the benzoic acid and the polyaspartic acid into 100-120 parts by weight of dimethyl sulfoxide, adding 20-45 parts by weight of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride and 15-50 parts by weight of N-hydroxysuccinimide under stirring, stirring and reacting for 1-5 hours at 10-30 ℃, adding 50-60 parts by weight of chitosan, heating to 50-70 ℃, stirring and reacting for 12-15 hours, dialyzing with a dialysis bag with the molecular weight of 3500, and freeze-drying to obtain the chitosan-benzoic acid-polyaspartic acid cross-linked polymer.
2. The heightening traditional Chinese medicine pellet of claim 1, which is characterized in that: the height-increasing traditional Chinese medicine pellet comprises the following raw medicines in parts by weight: 6-10 parts of ginseng, 3-6 parts of American ginseng, 6-10 parts of dogwood, 1-3 parts of pilose antler, 6-10 parts of schisandra chinensis, 10-15 parts of eucommia ulmoides, 6-10 parts of achyranthes bidentata, 6-10 parts of ophiopogon japonicus, 6-15 parts of rhizoma drynariae, 6-10 parts of codonopsis pilosula, 6-15 parts of astragalus membranaceus, 6-10 parts of prepared rehmannia root, 6-10 parts of mulberry, 6-10 parts of wolfberry, 3-10 parts of endothelium corneum gigeriae galli, 3-10 parts of hawthorn, 3-15 parts of Chinese yam, 6-10 parts of longan pulp, 6-10 parts of donkey-hide gelatin, 6-10 parts of poria, 3-6 parts of sea buckthorn, 6-10 parts of black sesame and 6-15 parts of human placenta;
120-150 parts of pharmaceutical auxiliary materials in the heightening traditional Chinese medicine pellet.
3. The heightening traditional Chinese medicine pellet of claim 1, which is characterized in that: the pharmaceutical excipients are prepared from starch, lactose and chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 2: 3: 1.
4. The preparation method of the heightening traditional Chinese medicine pellet of claim 1, which is characterized in that: the method comprises the following steps:
firstly, stir-frying the black sesame by a stir-frying method until the black sesame is exploded, and cooling to obtain stir-fried black sesame for later use;
secondly, frying the cleaned endothelium corneum gigeriae galli with slow fire until the surface color is deepened to obtain fried endothelium corneum gigeriae galli for later use;
thirdly, 6-10 parts by weight of ginseng to be dried, 3-6 parts by weight of American ginseng, 6-10 parts by weight of dogwood, 1-3 parts by weight of pilose antler, 6-10 parts by weight of schisandra chinensis, 10-15 parts by weight of eucommia ulmoides, 6-10 parts by weight of ophiopogon japonicus, 6-15 parts by weight of rhizoma drynariae, 6-10 parts by weight of codonopsis pilosula, 6-15 parts by weight of astragalus membranaceus, 6-10 parts by weight of prepared rehmannia root, 6-10 parts by weight of mulberry, 6-10 parts by weight of medlar, 3-10 parts by weight of hawthorn, 3-15 parts by weight of Chinese yam, 6-10 parts by weight of dried longan pulp, 6-10 parts by weight of donkey-hide gelatin, 6-10 parts by weight of poria cocos, 3-6 parts by weight of sea-buckthorn, 6-10 parts by weight of cooked black sesame obtained in the first step and 3-10 parts by weight of fried chicken's gizzard-membrane obtained in the step are added into a mashing machine to be crushed and ground to 100-200 meshes to obtain mixed powder for later use;
mixing and crushing 6-10 parts of achyranthes and 6-15 parts of human placenta to 20-50 meshes, adding water with the mass being 5-10 times of that of the mixture, boiling and extracting for 15-20 minutes, filtering, concentrating the filtrate, and drying to obtain dry extract powder;
fifthly, uniformly mixing the mixed powder obtained in the third step, the dry extract powder obtained in the fourth step and 120-150 parts of pharmaceutical excipients to obtain a traditional Chinese medicine mixture, preparing plain pills with the diameter of 2-3 mm by water, drying, and coating with a film coat to obtain the heightening traditional Chinese medicine micro-pills;
the pharmaceutical auxiliary materials comprise starch, lactose and a chitosan-benzoic acid-polyaspartic acid cross-linked polymer according to a mass ratio of 1-3: 1-4: 1, preparing a composition;
the chitosan-benzoic acid-polyaspartic acid cross-linked polymer is prepared by the following steps:
taking 12-18 parts by weight of benzoic acid and 8-10 parts by weight of polyaspartic acid, adding the benzoic acid and the polyaspartic acid into 100-120 parts by weight of dimethyl sulfoxide, adding 20-45 parts by weight of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride and 15-50 parts by weight of N-hydroxysuccinimide under stirring, stirring and reacting for 1-5 hours at 10-30 ℃, adding 50-60 parts by weight of chitosan, heating to 50-70 ℃, stirring and reacting for 12-15 hours, dialyzing with a dialysis bag with the molecular weight of 3500, and freeze-drying to obtain the chitosan-benzoic acid-polyaspartic acid cross-linked polymer.
5. The preparation method of the traditional Chinese medicine micro-pill for increasing height according to claim 4, which is characterized in that: in the fifth step, the film coating solution used in the film coating is composed of 4 to 8 parts by weight of hydroxypropyl methylcellulose, 0.1 to 0.5 part by weight of pore-forming agent polyethylene glycol, 0.1 to 0.3 part by weight of plasticizer glycerol and 100 parts by weight of water.
6. The method for preparing the heightening traditional Chinese medicine pellet according to any one of claims 4 or 5, characterized in that: step five, preparing plain pills with the diameter of 2-3 mm by water, comprising the following steps:
granulating the traditional Chinese medicine mixture, granulating the prepared granules with a 25-mesh sieve, rolling the granules in a coating pan, spraying water in sequence, scattering the rest traditional Chinese medicine mixture, blow-drying, repeating the operation, and sieving to obtain pellets with the diameter of 2-3 mm.
7. The preparation method of the traditional Chinese medicine micro-pill for increasing height according to claim 5, which is characterized in that: in the fifth step, the technological parameters of the film coating are as follows: the flow rate is 0.1-0.12 kg/min, and the pressure is 0.2-0.3 MPa; the drying temperature is 40-50 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111323034.0A CN114177246A (en) | 2021-11-10 | 2021-11-10 | Height-increasing traditional Chinese medicine pellet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111323034.0A CN114177246A (en) | 2021-11-10 | 2021-11-10 | Height-increasing traditional Chinese medicine pellet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114177246A true CN114177246A (en) | 2022-03-15 |
Family
ID=80601483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111323034.0A Pending CN114177246A (en) | 2021-11-10 | 2021-11-10 | Height-increasing traditional Chinese medicine pellet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114177246A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062846A (en) * | 1990-12-28 | 1992-07-22 | 重庆长江轮船公司 | The preparation method of medicine for promoting length of human body |
-
2021
- 2021-11-10 CN CN202111323034.0A patent/CN114177246A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062846A (en) * | 1990-12-28 | 1992-07-22 | 重庆长江轮船公司 | The preparation method of medicine for promoting length of human body |
Non-Patent Citations (5)
| Title |
|---|
| 刘佩: "壳聚糖-聚乳酸接枝共聚物的制备、药物缓释及生物相容性研究", 《中国优秀硕士学位论文全文数据库 (基础科学辑)》 * |
| 张丹瑛等: "壳聚糖-聚天冬氨酸-5-氟尿嘧啶纳米粒在小鼠体内的药代动力学(英文)", 《中国组织工程研究与临床康复》 * |
| 王慧等: "两亲性壳聚糖/槲皮素纳米胶束的制备及其理化性质研究", 《热带作物学报》 * |
| 艳慧等: "补肾地黄汤联合葡萄糖酸锌治疗儿童锌缺乏致身材矮小伴智力低下临床观察", 《新中医》 * |
| 黄伟华: "载米格列醇聚电解质复合药物纳米粒子的制备、表征及筛选的初步研究", 《中国优秀硕士学位论文全文数据库 (工程科技Ⅰ)》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100543427C (en) | Calcium carbonate granule | |
| JP5956475B2 (en) | Orally disintegrating tablets containing bitter mask granules | |
| CN106389344A (en) | Calcium carbonate particles and preparation method thereof | |
| CA2700224A1 (en) | Method of producing granules containing natural products derived substance such as chinese orthodox medicine extracts, crude drug extracts, and extracts derived from natural substances, and producing a tablet in use of said granules | |
| CN103948029B (en) | A kind of yin-deficiency constitution protective foods and its preparation method | |
| CN102626468A (en) | Traditional Chinese medicine combination for treating hepatitis B and preparing method and application thereof | |
| WO2006129668A1 (en) | Sugar-coated pill | |
| CN114177246A (en) | Height-increasing traditional Chinese medicine pellet and preparation method thereof | |
| CN107823180A (en) | A kind of simple micropill containing volatile oil and preparation method thereof | |
| CN110122887A (en) | Improve the dietary fiber chewable tablets and preparation method thereof of gastrointestinal function | |
| CN112914010A (en) | Phlegm-dampness constitution health-care solid beverage and preparation method thereof | |
| TWI402084B (en) | Microcapsules and method of preparing the same | |
| CN101007155A (en) | Gastric-dissolved and enteric-dissolved pills of traditional Chinese medicine capable of strengthening spleen and nourishing intestine and its preparation method | |
| CN109010514A (en) | Composition, health care product and the preparation method of altitude sickness prevention | |
| CN107410642A (en) | It is a kind of to be used to improve kelp cordyceps sinensis pressed candy of male's renal function and preparation method thereof | |
| CN103892006B (en) | Brain tonic lengthens one's life tea | |
| CN110548109B (en) | Traditional Chinese medicine composition for treating child anorexia and preparation method thereof | |
| CN101317924A (en) | Method for preparing capsule for tonifying the spleen and kidney | |
| CN111567801A (en) | A kind of sour jujube bee royal jelly tablet and preparation process thereof | |
| CN113288879B (en) | Preparation method of enteric-coated particles of carbasalate calcium | |
| JP7381799B1 (en) | Method for producing tablets containing long life herb and turmeric | |
| CN116531426B (en) | Sulfur-containing protamine pharmaceutical composition for preventing and treating leucopenia caused by chemotherapy and preparation method thereof | |
| CN114949135B (en) | Traditional Chinese medicine composition for treating digestive tract reaction after chemotherapy and preparation method thereof | |
| CN108669530A (en) | A kind of Hericium erinaceus composition, tablet and preparation method conducive to stomach health | |
| CN107837374A (en) | A kind of Tibetan medicine five tastes pomegranate stomach adhesive pellet and its preparation technology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220315 |