CN114158552A - Emamectin benzoate B2 water dispersible granule and preparation method thereof - Google Patents
Emamectin benzoate B2 water dispersible granule and preparation method thereof Download PDFInfo
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- CN114158552A CN114158552A CN202111329732.1A CN202111329732A CN114158552A CN 114158552 A CN114158552 A CN 114158552A CN 202111329732 A CN202111329732 A CN 202111329732A CN 114158552 A CN114158552 A CN 114158552A
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- Prior art keywords
- emamectin benzoate
- water dispersible
- dispersible granule
- preparation
- agent
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses emamectin benzoate B2 water dispersible granules which comprise the following components in percentage by mass: 5-30% of emamectin benzoate technical, 6-10% of dispersing agent, 3-6% of wetting agent, 1-5% of disintegrating agent and the balance of filler to 100%; the preparation method also comprises the following steps of adding the emamectin benzoate and the ingredients into a mixing kettle, uniformly stirring, sucking into a jet mill for jet milling, then pouring into a vacuum mixer, adding water, stirring, finally extruding, granulating and drying. The preparation process is simplified, the safety of the production process is improved, the running cost is reduced, the content of active ingredients is improved, the dispersibility is good, the disintegration is easy, the stability is high, the suspension rate is high, and the preparation process without solvent or dust ensures the safety and harmlessness of operators and environment.
Description
Technical Field
The invention relates to the technical field of pesticide preparation, and particularly relates to emamectin benzoate B2 water dispersible granules and a preparation method thereof.
Background
The emamectin benzoate is a high-efficiency pesticide, the dust pollution problem exists in powder and wettable powder in the existing preparation formulation, the water suspending agent is not easy to pour, and the layering problem often occurs after long-term standing, in the same preparation formulation, the instability of the preparation can be obviously influenced by using different dispersing agents, disintegrating agents and wetting agents, the granules are not disintegrated or the disintegration speed is slow, and the suspension rate is low. Therefore, the stable preparation can be prepared only by selecting proper auxiliary agents to prepare the emamectin benzoate water dispersible granules.
Disclosure of Invention
The invention aims to provide emamectin benzoate B2 water dispersible granules and a preparation method thereof aiming at the defects of the prior art.
In order to solve the problems, the technical scheme adopted by the invention is as follows:
the emamectin benzoate B2 water dispersible granule comprises the following components in percentage by mass: 5-30% of emamectin benzoate technical, 6-10% of dispersing agent, 3-6% of wetting agent, 1-5% of disintegrating agent and the balance of filler to 100%.
Further, the dispersing agent comprises one or more of lignosulfonate, starch and sodium pectate.
Further, the wetting agent comprises one or more of lignosulfate, sodium lauryl sulfate and alkyl naphthalene sulfonate.
Further, the disintegrating agent comprises one or more of sodium chloride, ammonium sulfate, croscarmellose sodium, low-substituted hydroxypropyl cellulose and polycarboxylate.
Further, the filler comprises one or more of light calcium carbonate, talcum powder, white carbon black, kaolin, corn starch and montmorillonite.
A preparation method of emamectin benzoate B2 water dispersible granules comprises the following steps:
1) sequentially adding the emamectin benzoate technical material, the dispersing agent, the wetting agent, the disintegrating agent and the filler into a mixing kettle, stirring for about 30 minutes, and uniformly mixing;
2) sucking the mixed material into a jet mill for jet milling at the rotating speed of 45HZ, the airtight sealing pressure of a grading wheel of 0.12-0.15MPa and the air inlet pressure of a negative pressure material suction of 0.25-0.4MPa, and milling to obtain D90 with the grain diameter of less than 10 microns;
3) pouring the crushed materials into a vacuum mixer, starting stirring, and adding a certain amount of water to change dry materials into wet materials; stirring for 20-30 min;
4) starting a granulator, uniformly adding the wet materials into the granulator for extrusion granulation, wherein the extrusion pores are 8-16 mm;
5) drying the extruded particles in a fluidized bed at 70-110 ℃.
Further, the moisture content of the wet material in the step 3) is kept between 10 and 20 percent.
Further, the water content of the emamectin benzoate B2 water dispersible granules is less than 3%.
Adopt the produced beneficial effect of above-mentioned technical scheme to lie in:
the invention simplifies the preparation process, improves the safety of the production process, reduces the operation cost, improves the content of effective components, has good dispersibility, easy disintegration, stability and high suspension rate, and the preparation process without solvent and dust ensures the safety and harmlessness of operators and environment.
The raw materials used in the invention are green pollution-free biological products, are not limited by the country, have less investment in facilities and equipment, are easy for large-scale production, have simple production process, are convenient to operate, and are safe to transport and use.
Detailed Description
The following examples further describe embodiments of the present invention in detail. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
The product is a high-efficiency biological agent, the medicament formula completely adopts commercially available materials as raw materials, the production is carried out at normal temperature and normal pressure, and no waste gas, waste water or waste residue is generated in the production process.
Example 1
The emamectin benzoate B2 water dispersible granule comprises the following components in percentage by mass: 20% of emamectin benzoate technical, 8% of dispersing agent, 5% of wetting agent, 3% of disintegrating agent and 64% of filling material.
Further, the dispersant is lignosulfonate;
further, the wetting agent is sodium lauryl sulfate.
Further, the disintegrant is sodium chloride.
Further, the filler is kaolin and corn starch.
A preparation method of emamectin benzoate B2 water dispersible granules comprises the following steps:
1) sequentially adding the emamectin benzoate technical material, the dispersing agent, the wetting agent, the disintegrating agent and the filler into a mixing kettle, stirring for about 30 minutes, and uniformly mixing;
2) sucking the mixed material into a jet mill for jet milling at the rotating speed of 45HZ, the airtight sealing pressure of a grading wheel of 0.15MPa and the negative pressure material sucking air inlet pressure of 0.4MPa, and milling to obtain D90 with the grain diameter of less than 10 microns;
3) pouring the crushed materials into a vacuum mixer, starting stirring, adding a certain amount of water to change the dry materials into wet materials, wherein the water content of the wet materials is 15%; stirring for 25 minutes;
4) starting a granulator, uniformly adding the wet materials into the granulator for extrusion granulation, wherein the extrusion pores are 8-16 mm;
5) and (3) drying the extruded particles in a fluidized bed at the temperature of 100 ℃.
Further, the water content of the emamectin benzoate B2 water dispersible granules is kept at 1.5%.
Example 2
The emamectin benzoate B2 water dispersible granule comprises the following components in percentage by mass: 5% of emamectin benzoate technical, 6% of dispersing agent, 3% of wetting agent, 1% of disintegrating agent and 85% of filling material.
Further, the dispersant is lignosulfonate; the wetting agent is sodium dodecyl sulfate; the disintegrant is sodium chloride; the filler is kaolin and corn starch.
The preparation method is the same as that of example 1.
Example 3
The emamectin benzoate B2 water dispersible granule comprises the following components in percentage by mass: 30% of emamectin benzoate technical, 10% of dispersing agent, 6% of wetting agent, 5% of disintegrating agent and 49% of filling material.
Further, the dispersant is lignosulfonate; the wetting agent is sodium dodecyl sulfate; the disintegrant is sodium chloride; the filler is kaolin and corn starch.
The preparation method is the same as that of example 1.
The abamectin B2 water dispersible granules prepared in the above examples 1-3 were subjected to quality inspection, and the results are shown in Table 1.
Detecting project indicators
Suspension rate (measured according to GB/T148252006 method)
Heat storage stability (determined according to GB/T19136-
Dispersibility (tested according to GB/T32775-2016)
Disintegration time (S): the determination method comprises the following steps: in another attempt, 0.5g of sample particles are added into a 90ml measuring cylinder with a plug at 25 ℃, the bottom of the measuring cylinder is used as the center, the speed is reversed at 2 s/time, and the time for the particles to completely disintegrate is recorded, namely the disintegration time.
TABLE 1
| Example 1 | Example 2 | Example 3 | |
| Suspension rate/% | 95.9 | 94.2 | 95.1 |
| Dispersibility/% | 97.2 | 96.5 | 96.8 |
| Disintegration time/s | 15 | 18 | 12 |
| Stability in Heat storage | Qualified | Qualified | Qualified |
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (8)
1. The emamectin benzoate B2 water dispersible granule is characterized by comprising the following components in percentage by mass: 5-30% of emamectin benzoate technical, 6-10% of dispersing agent, 3-6% of wetting agent, 1-5% of disintegrating agent and the balance of filler to 100%.
2. The emamectin benzoate B2 water dispersible granule according to claim 1, wherein the dispersing agent comprises one or more of lignosulfonate, starch and sodium pectate.
3. The emamectin benzoate B2 water dispersible granule according to claim 1, wherein the wetting agent comprises one or more of lignosulfate, sodium dodecyl sulfate and alkyl naphthalene sulfonate.
4. The emamectin benzoate B2 water dispersible granule according to claim 1, wherein the disintegrating agent comprises one or more of sodium chloride, ammonium sulfate, croscarmellose sodium, low-substituted hydroxypropyl cellulose and polycarboxylate.
5. The emamectin benzoate B2 water dispersible granule according to claim 1, wherein the filler comprises one or more of light calcium carbonate, talcum powder, white carbon black, kaolin, corn starch and montmorillonite.
6. A preparation method of emamectin benzoate B2 water dispersible granules is characterized by comprising the following steps:
1) sequentially adding the emamectin benzoate technical material, the dispersing agent, the wetting agent, the disintegrating agent and the filler into a mixing kettle, stirring for about 30 minutes, and uniformly mixing;
2) sucking the mixed material into a jet mill for jet milling at the rotating speed of 45HZ, the airtight sealing pressure of a grading wheel of 0.12-0.15MPa and the air inlet pressure of a negative pressure material suction of 0.25-0.4MPa, and milling to obtain D90 with the grain diameter of less than 10 microns;
3) pouring the crushed materials into a vacuum mixer, starting stirring, and adding a certain amount of water to change dry materials into wet materials; stirring for 20-30 min;
4) starting a granulator, uniformly adding the wet materials into the granulator for extrusion granulation, wherein the extrusion pores are 8-16 mm;
5) drying the extruded particles in a fluidized bed at 70-110 ℃.
7. The method for preparing emamectin benzoate B2 water dispersible granules according to claim 6, wherein the moisture content of the wet material in the step 3) is kept between 10 and 20 percent.
8. The method for preparing emamectin benzoate B2 water dispersible granules according to claim 6, wherein the water content of the emamectin benzoate B2 water dispersible granules is less than 3%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111329732.1A CN114158552A (en) | 2021-11-10 | 2021-11-10 | Emamectin benzoate B2 water dispersible granule and preparation method thereof |
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| CN202111329732.1A CN114158552A (en) | 2021-11-10 | 2021-11-10 | Emamectin benzoate B2 water dispersible granule and preparation method thereof |
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| CN202111329732.1A Pending CN114158552A (en) | 2021-11-10 | 2021-11-10 | Emamectin benzoate B2 water dispersible granule and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1669422A (en) * | 2005-03-14 | 2005-09-21 | 武汉绿世纪生物工程有限责任公司 | Methylamino avermectin benzoate water dispersant granule and preparation method thereof |
| CN101911934A (en) * | 2010-01-28 | 2010-12-15 | 惠州市银农科技有限公司 | Emamectin benzoate water dispersible granule capable of fast disintegrating and preparation method thereof |
| CN111134116A (en) * | 2020-01-02 | 2020-05-12 | 中化化工科学技术研究总院有限公司 | Emamectin benzoate water dispersible granule and preparation method thereof |
-
2021
- 2021-11-10 CN CN202111329732.1A patent/CN114158552A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1669422A (en) * | 2005-03-14 | 2005-09-21 | 武汉绿世纪生物工程有限责任公司 | Methylamino avermectin benzoate water dispersant granule and preparation method thereof |
| CN101911934A (en) * | 2010-01-28 | 2010-12-15 | 惠州市银农科技有限公司 | Emamectin benzoate water dispersible granule capable of fast disintegrating and preparation method thereof |
| CN111134116A (en) * | 2020-01-02 | 2020-05-12 | 中化化工科学技术研究总院有限公司 | Emamectin benzoate water dispersible granule and preparation method thereof |
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Application publication date: 20220311 |