CN114099476B - Functional gel layer, scar patch and preparation method thereof - Google Patents
Functional gel layer, scar patch and preparation method thereof Download PDFInfo
- Publication number
- CN114099476B CN114099476B CN202111388685.8A CN202111388685A CN114099476B CN 114099476 B CN114099476 B CN 114099476B CN 202111388685 A CN202111388685 A CN 202111388685A CN 114099476 B CN114099476 B CN 114099476B
- Authority
- CN
- China
- Prior art keywords
- gel layer
- parts
- scar
- functional
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a functional gel layer, a scar patch and a preparation method thereof, relating to the technical field of medical supplies; the functional gel layer comprises the following components in parts by weight: 2-30 parts of protein repairing agent, 0.5-10 parts of sodium hyaluronate and the balance of purified water, wherein the sum of the parts by weight of the components is 100 parts; the protein repairing agent is at least one selected from collagen and mussel mucin. The scar patch can be directly applied to non-closed wound surfaces, can reduce itching degree while inhibiting scar formation, promote wound surface healing and accelerate functional recovery of skin tissues.
Description
Technical Field
The invention relates to the technical field of medical supplies, in particular to a functional gel layer, a scar patch and a preparation method thereof.
Background
Various wounds, burns, operations, infection, injection and the like can cause pathological scars of skin, the formation process of the scars is the repair process of tissue injury, and the scars are marks formed after the skin tissue is injured and healed. When the skin is damaged deeply into the dermis reticular layer, any wound healing is accompanied by scar formation with different degrees, the matrix of the scar is connective tissue, and the main component is collagen fibers. According to the differences of surface morphology, histology and clinical characteristics, common scars can be classified into flat scars, hypertrophic scars, atrophic scars, sunken scars and contractual scars. Scar is the growth of fibrous tissue and is a manifestation of self-healing after skin injury.
Skin scars pose several hazards to the human body: the local tissue of the scar is thickened or sunken, the surface is not smooth, pigmentation and pigment loss exist, and the appearance can be greatly influenced; the scar part often has uncomfortable symptoms such as itching, pain and the like, and the patient can often not tolerate the scar part; severe scar contractures can cause deformity, thereby affecting the function of the part; the scar may cause a heavy psychological burden to the patient, resulting in psychological disorders to the patient, thereby affecting his physical and mental health. Scar patients can be removed by surgical operations, physical means, medical cosmetic means such as medicines, etc., to obtain good effect of improving appearance. The scar can be improved by medical beauty treatment, and common scar treatment methods include surgical methods, physical therapy and drug therapy, wherein surgery is a relatively thorough method for treating the scar, but the injury is larger, the scar is also possibly left, and the physical therapy and the drug therapy are more suitable for the scar with lighter degree. At present, the prevention and treatment of the wound scar by adopting scar plaster or scar gel is still the main method of clinical application.
However, the current scar plaster still has a plurality of defects:
1) Application direction limitation: the existing scar plaster cannot be applied to non-closed wound surfaces;
2) The product has single function: the existing scar plaster generally consists of a backing layer, a gel layer and a release layer; but only can provide a wet healing environment, keep moisture of a closed wound surface, and can not promote wound surface healing and function recovery;
3) The product structure composition does not contain moisture, and the moisture evaporation rate of the organism is completely slowed down to realize the wet healing environment, so that the hydration effect on the wound surface is weak;
4) Repeated application affects the product effect: although the existing products can be repeatedly applied, bacterial pollution is easy to occur in the repeated use process, and the curative effect cannot be ensured;
5) Difficulty in combined medication: the conventional silica gel scar paste is difficult to combine with medicines for inhibiting scar formation, promoting wound healing or inhibiting wound bacteria in the preparation process;
6) When in use, the healed wound is easy to produce itching.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a functional gel layer, a scar patch and a preparation method thereof, wherein the functional gel layer can be directly applied to non-closed wound surfaces, can inhibit scar formation, reduce itching degree, promote wound healing and accelerate functional recovery of skin tissues.
In order to solve the technical problems, the invention provides the following technical scheme:
in a first aspect, a functional gel layer is provided, the functional gel layer comprising the following components in parts by weight: 2-30 parts of protein repairing agent, 0.5-10 parts of sodium hyaluronate and the balance of purified water, wherein the sum of the parts by weight of the components is 100 parts;
the protein repairing agent is at least one selected from collagen and mussel mucin.
Further, when the protein repairing agent is two of collagen and mussel mucin, the mass ratio of the collagen to the mussel mucin is 1-2:1.
Further, the functional gel layer also comprises 0.05 to 2 parts of borneol.
Further, the functional gel layer also comprises 0.5-2 parts of menthol.
Further, the functional gel layer also comprises 0.1-2 parts of sodium alginate.
Further, the functional gel layer also comprises 0.1-3 parts of sodium polyglutamate.
Further, the functional gel layer also comprises 0.1 to 1 part of carboxymethyl chitosan and 2 to 5 parts of glycerol.
In a second aspect, the present invention provides a scar patch applicable to non-occlusive wound surfaces, the scar patch comprising a release layer, a functional gel layer, a medical silicone gel layer and a backing layer, which are sequentially arranged.
Further, the medical silicone gel layer is a conventional medical gel layer, preferably a two-component silicone-based gel.
Further, the thickness of the medical silicone gel layer is 100-500 μm.
Further, the functional gel layer has a thickness of 25 to 200 μm.
In a third aspect, there is provided a method for preparing the scar patch according to the second aspect, comprising the steps of:
(1) Weighing the raw materials according to the proportion of the raw materials of the functional gel layer for later use;
(2) Adding protein repairing agent and sodium hyaluronate into purified water, stirring at stirring rate of 150-200r/min at normal temperature for 30-120min, and stirring to obtain functional gel layer;
(3) Uniformly coating a medical silica gel layer on a back lining layer, and drying and curing; the drying temperature is 75-150 ℃;
(4) Uniformly coating or spraying the functional gel layer on the medical silica gel layer obtained in the step (3), drying and forming at 25-50 ℃ under the vacuum degree of 40-60 pa, and covering a release layer to obtain a formed scar patch;
(5) Thermally crosslinking the formed scar patch;
(6) Cutting and packaging the scar patch obtained in the step (5), and sterilizing by ethylene oxide to obtain the scar patch.
Compared with the prior art, the invention has the following beneficial effects:
1. the functional gel layer of the invention adopts specific raw material components for combination, wherein, collagen can promote the metabolism of wound tissues, improve the color of the wound, lighten scars, tighten skin and keep moisture; mussel mucin can promote the repair of wound skin injury, and has antipruritic and antioxidant effects; the sodium hyaluronate has the functions of maintaining and supplementing water content of wound surface, promoting local metabolism, forming a protective film for the wound surface and reducing skin infection risk. The functional gel layer contains the bioactive materials, so that the functional gel layer can be contacted with a wound surface which is not closed yet, a bracket is provided for regenerating and repairing the wound surface, and the migration and crawling of surrounding tissue cells can be promoted, and the regenerating and repairing of the wound surface can be promoted; meanwhile, the functional gel layer has the functions of stopping bleeding and absorbing seepage and can be degraded and absorbed; the functional gel layer can promote regeneration and repair and prevent water loss, and the dual mechanism effect can effectively prevent scar formation and reduce the itching degree of the wound surface.
2. The invention ensures that the functional gel layer is not degraded too quickly and the acting time is prolonged through the heat crosslinking treatment.
Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Detailed Description
For a more complete understanding of the present invention, reference should be made to the following descriptions of the embodiments; it will be apparent that the embodiments described below are only some, but not all, embodiments of the invention; all other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to fall within the scope of the invention.
The features, advantages and advantages of the present invention will become apparent to those skilled in the art from a reading of the present disclosure.
All percentages, fractions and ratios are by weight of the total composition of the present invention, unless otherwise specified. The term "weight content" is used herein to denote the symbol "%".
The terms "comprising," "including," "containing," "having," or other variations thereof herein are intended to cover a non-closed inclusion, without distinguishing between them. The term "comprising" means that other steps and ingredients may be added that do not affect the end result. The term "comprising" also includes the terms "consisting of and" consisting essentially of. The compositions and methods/processes of the present invention can comprise, consist of, and consist essentially of the essential elements and limitations described herein, as well as additional or optional ingredients, components, steps, or limitations of any of the embodiments described herein.
Examples 1 to 4
Example 1:
the embodiment provides a scar patch which can be applied to a non-closed wound surface and comprises a back lining layer, a gel layer and a release layer, wherein the gel layer sequentially comprises a medical silica gel layer and a functional gel layer.
The medical silica gel layer is a bi-component polysiloxane gel;
the functional gel layer comprises the following components in parts by weight: 5 parts of sodium hyaluronate, 10 parts of collagen, 5 parts of mussel mucin and the balance of purified water, wherein the sum of the parts by weight of the components is 100 parts;
the preparation method of the scar patch comprises the following specific steps:
step 1: accurately weighing the raw materials according to the proportion of the raw materials of the gel layer (medical silica gel layer and functional gel layer) for later use;
step 2: adding mussel mucin, collagen and sodium hyaluronate into purified water, stirring at stirring rate of 150r/min at normal temperature for 120min, and stirring to obtain functional gel layer;
step 3: stirring the medical silica gel component A and the medical silica gel component B for 30min at a stirring rate of 150r/min according to a mass ratio of 1:1 at normal temperature, and uniformly stirring to obtain a medical silica gel layer for later use;
step 4: the medical silica gel layer is uniformly coated on the back lining layer, and is subjected to drying and curing treatment. The curing and drying temperature is 115 ℃;
step 5: uniformly coating or spraying the functional gel layer on the semi-cured medical silica gel layer obtained in the step 4, drying and forming at a low temperature in vacuum, and covering a release layer; the vacuum drying condition was 25℃and the vacuum degree was 60Pa, and the drying was carried out for 3 hours.
Step 6: thermally crosslinking the formed scar paste; the thermal crosslinking conditions are: the mixture was crosslinked at 45℃under a vacuum of 50pa for 3 hours.
Step 7: cutting and packaging the scar patch, and sterilizing with ethylene oxide to obtain the scar patch.
In this embodiment, the thickness of the medical silicone gel layer is 100 μm; the functional gel layer had a thickness of 50 μm.
The scar patch of the embodiment can promote wound healing, reduce scar formation and reduce itch in the wound healing process.
Example 2:
the embodiment provides a scar patch which can be applied to a non-closed wound surface and comprises a back lining layer, a gel layer and a release layer, wherein the gel layer sequentially comprises a medical silica gel layer and a functional gel layer.
The medical silica gel layer is a bi-component polysiloxane gel;
the functional gel layer comprises the following components in parts by weight: 0.5 part of sodium hyaluronate, 25 parts of collagen, 2 parts of menthol, 5 parts of glycerol and the balance of purified water, wherein the sum of the parts by weight of the components is 100 parts;
the preparation method of the scar patch comprises the following specific steps:
step 1: accurately weighing the raw materials according to the proportion of the raw materials of the backing layer, the gel layer (medical silica gel layer, functional gel layer) and the release layer for later use;
step 2: adding collagen and sodium hyaluronate into purified water, stirring the functional substances at a stirring rate of 200r/min for 30min at normal temperature, adding menthol and glycerol, and stirring and mixing to obtain functional gel layer;
step 3: stirring the medical silica gel component A and the medical silica gel component B for 30min at a stirring rate of 150r/min according to a mass ratio of 1:1 at normal temperature, and uniformly stirring to obtain a medical silica gel layer for later use;
step 4: uniformly coating a medical silica gel layer on a back lining layer, and curing; the curing and drying temperature is 120 ℃;
step 5: uniformly coating or spraying the functional gel layer on the semi-cured medical silica gel layer obtained in the step 4, drying and forming at a low temperature in vacuum, and covering a release layer; the vacuum drying condition was 30℃and the vacuum degree was 50pa, and the drying was carried out for 2 hours.
Step 6: thermally crosslinking the formed scar paste; the thermal crosslinking conditions are: crosslinking at 50℃under a vacuum of 40pa for 2 hours.
Step 7: cutting and packaging the scar patch, and sterilizing with ethylene oxide to obtain the scar patch.
In this embodiment, the thickness of the medical silicone gel layer is 120 μm; the functional gel layer had a thickness of 100 μm.
The scar patch of the embodiment can promote wound healing, reduce scar formation and reduce itch in the wound healing process.
Example 3:
the embodiment provides a scar patch which can be applied to a non-closed wound surface and comprises a back lining layer, a gel layer and a release layer, wherein the gel layer sequentially comprises a medical silica gel layer and a functional gel layer.
The medical silica gel layer is a bi-component polysiloxane gel;
the functional gel layer comprises the following components in parts by weight: 5 parts of sodium hyaluronate, 25 parts of mussel mucin, 0.05 part of borneol and the balance of purified water, wherein the sum of the parts by weight of the components is 100 parts;
the preparation method of the scar patch comprises the following specific steps:
step 1: accurately weighing the raw materials according to the proportion of the raw materials of the backing layer, the gel layer (medical silica gel layer, functional gel layer) and the release layer for later use;
step 2: adding mussel mucin and sodium hyaluronate into purified water, stirring the functional substances at a stirring rate of 150r/min at normal temperature for 60min, adding Borneolum Syntheticum, stirring, and mixing to obtain functional gel layer;
step 3: stirring the medical silica gel component A and the medical silica gel component B for 25min at a stirring rate of 200r/min according to a mass ratio of 1:1 at normal temperature, and uniformly stirring to obtain a medical silica gel layer for later use;
step 4: uniformly coating a medical silica gel layer on a back lining layer, and curing; the curing and drying temperature is 120 ℃;
step 5: uniformly coating or spraying the functional gel layer on the semi-cured medical silica gel layer obtained in the step 4, drying and forming at a low temperature in vacuum, and covering a release layer; the vacuum drying condition is 40 ℃ and the vacuum degree is 40pa, and the drying is carried out for 3 hours.
Step 6: thermally crosslinking the formed scar paste; the thermal crosslinking conditions are: crosslinking for 3 hours at 45 ℃ under a vacuum of 35 pa.
Step 7: cutting and packaging the scar patch, and sterilizing with ethylene oxide to obtain the scar patch.
In this embodiment, the thickness of the medical silicone gel layer is 100 μm; the functional gel layer had a thickness of 25 μm.
The scar patch of the embodiment can promote wound healing, reduce scar formation and reduce itch in the wound healing process.
Example 4:
the embodiment provides a scar patch which can be applied to a non-closed wound surface and comprises a back lining layer, a gel layer and a release layer, wherein the gel layer sequentially comprises a medical silica gel layer and a functional gel layer.
The medical silica gel layer is a bi-component polysiloxane gel;
the functional gel layer comprises the following components in parts by weight: 5 parts of sodium hyaluronate, 5 parts of collagen, 5 parts of mussel mucin, 0.1 part of borneol, 0.5 part of menthol, 2 parts of glycerin, 0.1 part of sodium alginate, 0.1 part of sodium polyglutamate, 0.2 part of carboxymethyl chitosan and the balance of purified water, wherein the sum of the weight parts of all the components is 100;
the preparation method of the scar patch comprises the following specific steps:
step 1: accurately weighing the raw materials according to the proportion of the raw materials of the backing layer, the gel layer (medical silica gel layer, functional gel layer) and the release layer for later use;
step 2: adding collagen, sodium hyaluronate and mussel mucin into purified water, stirring the functional substances at a stirring rate of 160r/min for 45min at normal temperature, adding Borneolum Syntheticum, mentholum, glycerol, sodium alginate, sodium polyglutamate and carboxymethyl chitosan, stirring, and mixing to obtain functional gel layer;
step 3: stirring the medical silica gel component A and the medical silica gel component B for 35min at a stirring rate of 180r/min according to a mass ratio of 1:1 at normal temperature, and uniformly stirring to obtain a medical silica gel layer for later use;
step 4: uniformly coating a medical silica gel layer on a back lining layer, and curing; the curing and drying temperature is 130 ℃;
step 5: uniformly coating or spraying the functional gel layer on the semi-cured medical silica gel layer obtained in the step 4, drying and forming at a low temperature in vacuum, and covering a release layer; the vacuum drying condition was 50℃and the vacuum degree was 40pa, and the drying was carried out for 2 hours.
Step 6: thermally crosslinking the formed scar paste; the thermal crosslinking conditions are: crosslinking at 50℃under a vacuum of 40pa for 3.5 hours.
Step 7: cutting and packaging the scar patch, and sterilizing with ethylene oxide to obtain the scar patch.
In this embodiment, the thickness of the medical silicone gel layer is 200 μm; the functional gel layer had a thickness of 200 μm.
The scar patch of the embodiment can promote wound healing, reduce scar formation and reduce itch in the wound healing process.
Effect testing
50 cases of scar hyperplasia after burn are selected, wherein the ratio of cases of unhealed wound surface to healed wound surface is 1:1, the cases are randomly divided into 5 groups, and the number of the unhealed wound surface and healed wound surface cases in each group is the same; the scar patches prepared in examples 1-4 of the present invention and the commercially available scar patches (composed of medical silicone gel (two-component silicone gel), silicone mesh film and backing protective layer) were used for treatment when the wound did not heal and healed, respectively.
The using method is as follows: firstly cleaning the skin of an affected part, removing a release layer, attaching a scar on the wound surface, and replacing once every 2-3 days for 1-3 months until the wound surface heals, the scar is softened and the color of the affected part is light.
Results:
1. safety test results
The test group is used for 40 cases of patients with hyperplastic scars, and no adverse event occurs, which indicates that the scar plaster has higher safety.
2. Functional test results, the test results are shown in table 1.
Table 1:
| sample of | Has obvious effect | Effective and effective | Invalidation of | Obvious efficiency (%) |
| Example 1 | 10 | 0 | 0 | 100％ |
| Example 2 | 10 | 0 | 0 | 100％ |
| Example 3 | 10 | 0 | 0 | 100％ |
| Example 4 | 10 | 0 | 0 | 100％ |
| Control group | 5 | 1 | 4 | 50％ |
Efficacy assessment criteria: the effect is shown: wound healing and scar softening; the method is effective: the symptoms are improved to a certain extent; invalidation: the symptoms are not improved or aggravated.
Note that: the obvious effect cases of the control group are all cases of wound healing, and the treatment effect is not obvious or obvious for the case of unhealed wound.
Healing time: for the cases where the wound surface is not healed, the average healing time of the wound surface of the patient in the test group is 5 days.
As can be obtained from table 1 and experimental records, 40 cases (100%) of wound surface effects of the test group, 5 cases (50%) of the control group (commercial similar products), 4 cases (40%) of the control group, wherein the effective cases of the control group are all cases of wound surface healing, and the treatment effect is not obvious or obvious for the case of unhealed wound surface; meanwhile, the color of the wound surface of all test groups is basically consistent with that of normal skin, and the color of the wound surface of the obvious effect case of the control group is obviously different from that of the normal skin; meanwhile, the number of cases of skin itch generated by all patients in the test group is 1, the number of cases of skin itch generated by patients in the control group is 5, and the degree of itch is smaller than that of the control group; i.e. the test group according to the invention is significantly better than the control group.
According to the test results in Table 1, the functional gel layer of the invention is prepared by combining specific raw material components, can contact a wound surface which is not closed yet, provides a support for wound surface regeneration and repair, can promote migration and crawling of surrounding tissue cells, and promotes wound surface regeneration and repair; meanwhile, the functional gel layer has the functions of stopping bleeding and absorbing seepage and can be degraded and absorbed; the functional gel layer can promote regeneration and repair and prevent water loss, and the dual mechanism effect can effectively prevent scar formation and reduce the itching degree of the wound surface.
The foregoing has described in detail the technical solutions provided by the embodiments of the present invention, and specific examples have been applied to illustrate the principles and implementations of the embodiments of the present invention, where the above description of the embodiments is only suitable for helping to understand the principles of the embodiments of the present invention; meanwhile, as for those skilled in the art, according to the embodiments of the present invention, there are variations in the specific embodiments and the application scope, and the present description should not be construed as limiting the present invention.
Claims (4)
1. The preparation method of the scar patch is characterized by comprising the following steps of:
(1) Weighing the raw materials according to the proportion of the raw materials of the functional gel layer for later use;
the functional gel layer comprises the following components in parts by weight: 2-30 parts of protein repairing agent, 0.5-10 parts of sodium hyaluronate, 0.1-2 parts of sodium alginate, 0.1-3 parts of sodium polyglutamate, 0.1-1 part of carboxymethyl chitosan, 2-5 parts of glycerol and the balance of purified water, wherein the sum of the weight parts of the components is 100 parts;
(2) Adding protein repairing agent and sodium hyaluronate into purified water, stirring at stirring rate of 150-200r/min at normal temperature for 30-120min, adding sodium alginate, sodium polyglutamate, carboxymethyl chitosan and glycerol, stirring, and mixing to obtain functional gel layer;
(3) Uniformly coating a medical silica gel layer on a back lining layer, and drying and curing; the drying temperature is 75-150 ℃;
(4) Uniformly coating or spraying the functional gel layer on the medical silica gel layer obtained in the step (3), drying and forming at 25-50 ℃ under the vacuum degree of 40-60 pa, and covering a release layer to obtain a formed scar patch;
(5) Thermally crosslinking the formed scar patch;
(6) Cutting and packaging the scar paste obtained in the step (5), and sterilizing ethylene oxide to obtain the scar paste;
the protein repairing agent is at least one of collagen and mussel mucin;
and when the protein repairing agent is two of collagen and mussel mucin, the mass ratio of the collagen to the mussel mucin is 1-2:1.
2. The method of claim 1, wherein the functional gel layer further comprises 0.05-2 parts of borneol.
3. The method of claim 1, wherein the functional gel layer further comprises 0.5-2 parts menthol.
4. The method of claim 1, wherein the medical silicone gel layer is a bi-component silicone gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111388685.8A CN114099476B (en) | 2021-11-22 | 2021-11-22 | Functional gel layer, scar patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111388685.8A CN114099476B (en) | 2021-11-22 | 2021-11-22 | Functional gel layer, scar patch and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114099476A CN114099476A (en) | 2022-03-01 |
| CN114099476B true CN114099476B (en) | 2023-07-28 |
Family
ID=80439540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111388685.8A Active CN114099476B (en) | 2021-11-22 | 2021-11-22 | Functional gel layer, scar patch and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114099476B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114699508A (en) * | 2022-04-12 | 2022-07-05 | 南京天朗制药有限公司 | Silicone gel and preparation method and application thereof |
| CN114948787A (en) * | 2022-06-15 | 2022-08-30 | 绽妍生物科技有限公司 | Skin moisturizing composition, cosmetic containing composition and preparation method |
| CN114948788B (en) * | 2022-06-15 | 2023-11-24 | 绽妍生物科技有限公司 | Triple protein composition for relieving and repairing and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190132291A (en) * | 2018-05-18 | 2019-11-27 | 포항공과대학교 산학협력단 | Hydrogel formulation based microneedle adhesive patch |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX362459B (en) * | 2013-02-19 | 2019-01-18 | Johnson & Johnson Consumer Inc | Methods and compositions for improving appearance and formation of scar tissue. |
| CN109847055A (en) * | 2018-12-29 | 2019-06-07 | 济南秦鲁药业科技有限公司 | Medical scar plaster and preparation method thereof |
| CN111991608B (en) * | 2020-08-27 | 2021-10-01 | 振德医疗用品股份有限公司 | Wound surface covering and preparation method thereof |
-
2021
- 2021-11-22 CN CN202111388685.8A patent/CN114099476B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190132291A (en) * | 2018-05-18 | 2019-11-27 | 포항공과대학교 산학협력단 | Hydrogel formulation based microneedle adhesive patch |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114099476A (en) | 2022-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114099476B (en) | Functional gel layer, scar patch and preparation method thereof | |
| CN108686255B (en) | Biological dressing for preventing scar formation and preparation method thereof | |
| US6780439B2 (en) | Wound treatment solution and method for using same | |
| CN107899003B (en) | Chitosan oligosaccharide medical wound care membrane and preparation method thereof | |
| CN105250696A (en) | Traditional Chinese medicine gel capable of promoting skin wound to heal and preparation method of traditional Chinese medicine gel | |
| Doanh et al. | The use of a water extract from the bark of Choerospondias axillaris in the treatment of second decree burns | |
| Burd | Evaluating the use of hydrogel sheet dressings in comprehensive burn wound care | |
| CN109045069B (en) | Earthworm syrup nano-silver hydrogel patch and preparation method thereof | |
| WO2017030388A1 (en) | Composition for treating skin wounds | |
| CN108686103B (en) | Hemostatic traditional Chinese medicine composition and multifunctional emergency hemostatic composite material | |
| Khorasani et al. | The effects of Aloe Vera cream on split-thickness skin graft donor site management: a randomized, blinded, placebo-controlled study | |
| CN105233271A (en) | Anti-scaring andrias skin collagen burn cream and preparation method thereof | |
| Haque et al. | Effectiveness of Chitosan versus Collagen Membrane for Wound Healing in Maxillofacial Soft Tissue Defects: A Comparative Clinical Study. | |
| CN109674743B (en) | Wound care gel and preparation method thereof | |
| CN1068785C (en) | Chinese patent medicine for external application for curing diseases of scald, burn and dermal ulcer | |
| CN113368202A (en) | Externally-applied soaking cold compress liquid for burns and scalds and preparation method thereof | |
| CN107982300B (en) | Spray and preparation method and application thereof | |
| CN109498562B (en) | Emergency burn care solution and preparation method thereof | |
| CN107397974B (en) | Wound plaster for treating chronic wound | |
| CN102178795B (en) | External medicine for treating burns and scalds and preparation method of medicine | |
| CN112773843A (en) | External liquid for treating burn and scald | |
| CN118236531A (en) | Self-powered hydrogel dressing patch and preparation method and application thereof | |
| CN111388749A (en) | Wound surface dressing with skin affinity | |
| CN118436752A (en) | Preparation method and application method of scar softening and leveling medicament | |
| CN116212089A (en) | Medical dressing containing high molecular water-absorbing resin and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |