CN114081891A - Preparation process and application of five-vitamin glucose - Google Patents
Preparation process and application of five-vitamin glucose Download PDFInfo
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 157
- 239000008103 glucose Substances 0.000 title claims abstract description 157
- 229940088594 vitamin Drugs 0.000 title claims abstract description 24
- 239000011782 vitamin Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 claims abstract description 8
- 201000010099 disease Diseases 0.000 claims abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 5
- 208000005577 Gastroenteritis Diseases 0.000 claims abstract 2
- 239000000463 material Substances 0.000 claims description 55
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 26
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 24
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 13
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 13
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 13
- 229930003471 Vitamin B2 Natural products 0.000 claims description 13
- 229930003268 Vitamin C Natural products 0.000 claims description 13
- 229960003512 nicotinic acid Drugs 0.000 claims description 13
- 235000001968 nicotinic acid Nutrition 0.000 claims description 13
- 239000011664 nicotinic acid Substances 0.000 claims description 13
- 229960002477 riboflavin Drugs 0.000 claims description 13
- 235000019164 vitamin B2 Nutrition 0.000 claims description 13
- 239000011716 vitamin B2 Substances 0.000 claims description 13
- 235000019154 vitamin C Nutrition 0.000 claims description 13
- 239000011718 vitamin C Substances 0.000 claims description 13
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims description 12
- 229960002061 ergocalciferol Drugs 0.000 claims description 12
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims description 12
- 235000001892 vitamin D2 Nutrition 0.000 claims description 12
- 239000011653 vitamin D2 Substances 0.000 claims description 12
- 229930003451 Vitamin B1 Natural products 0.000 claims description 8
- 229960003495 thiamine Drugs 0.000 claims description 8
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 8
- 235000010374 vitamin B1 Nutrition 0.000 claims description 8
- 239000011691 vitamin B1 Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 208000020670 canker sore Diseases 0.000 claims 1
- 208000021735 chronic enteritis Diseases 0.000 claims 1
- 208000023652 chronic gastritis Diseases 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 238000009827 uniform distribution Methods 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 description 9
- 235000013343 vitamin Nutrition 0.000 description 9
- 239000000047 product Substances 0.000 description 5
- 208000000412 Avitaminosis Diseases 0.000 description 3
- 206010021135 Hypovitaminosis Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 208000030401 vitamin deficiency disease Diseases 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920002527 Glycogen Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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Abstract
The invention discloses a preparation process and application of five-dimensional glucose. The preparation process comprises pretreatment, release mixing, premixing and total mixing. The preparation process improves the preparation method of the five-dimensional glucose, so that the obtained five-dimensional glucose has uniform distribution of all components and stable quality, and the quality of the five-dimensional glucose is stable. The invention also discloses the application of the five-vitamin glucose in the medicine for treating the digestive tract diseases, and the total effective rate of the five-vitamin glucose on the gastroenteritis reaches 100 percent through clinical observation.
Description
Technical Field
The invention relates to the field of medicine preparation, and in particular relates to a preparation process and application of five-vitamin glucose.
Background
The phenomenon of sub-health of modern people is very common, and most of the phenomena are closely related to vitamin deficiency. Vitamins are a general term for a series of organic compounds that regulate the metabolism of organisms. Vitamin deficiency can cause serious health problems, and proper intake of vitamins can keep the body strong and healthy. Glucose is the main source of energy required by the human body, and is oxidized in the body to carbon dioxide and water, and simultaneously supplies heat, or is stored in the form of glycogen.
The five-vitamin glucose is a compound preparation, belongs to vitamin medicines, and is mainly used for various diseases caused by vitamin deficiency. Vitamin B1 (C) is contained in five-dimensional glucose per 1g, according to the record of drug standards (national standards for local increase of chemical drugs) (WS-10001- (HD-0405) -2002)12H17CIN4OS & HCl) should be 96-156 μ g; vitamin B2 (C)17H20N4O6) 64-104 μ g; contains vitamin C (C)6H8O6) 1.7-2.3 mg; containing nicotinic acid (C)6H5NO2) 0.85-1.15 mg.
The five-vitamin glucose on the market has different preparation methods due to different manufacturers, and the content of each component in the five-vitamin glucose is different. The existing five-dimensional glucose has the problems that the distribution of all components is not uniform, the components contained in each bag are not uniform, the quality is unstable and the like when the five-dimensional glucose is packaged in bags.
Disclosure of Invention
The first purpose of the invention is to provide a preparation process of five-dimensional glucose, which is improved by a preparation method of the five-dimensional glucose, so that the components contained in the five-dimensional glucose are uniformly distributed and have stable quality, and the quality of the five-dimensional glucose is stable.
The second purpose of the invention is to provide an application of the five-vitamin glucose prepared by the preparation process in preparing a medicament for treating digestive tract diseases.
The invention discloses a preparation process of five-dimensional glucose, which comprises the following steps: A. pretreatment: respectively taking 150 parts by weight of glucose, 0.012 part by weight of vitamin B2, 0.3 part by weight of vitamin C, 0.0003 part by weight of vitamin D2 and 0.15 part by weight of nicotinic acid, crushing and sieving to obtain pretreated glucose, pretreated vitamin C, pretreated nicotinic acid, pretreated vitamin D2 and pretreated vitamin B2; 0.018 portion of vitamin B1 is taken for standby; B. double release mixing: firstly, mixing 3 parts of pretreated glucose with 0.3 part of pretreated vitamin C, and then adding 6 parts of pretreated glucose for mixing to obtain a first time release material; mixing 1.5 parts of pretreated glucose with 0.15 part of pretreated nicotinic acid, then adding 3 parts of pretreated glucose for mixing, then adding 6 parts of pretreated glucose for mixing to obtain a second release material; ③ mixing 0.18 part of pretreated glucose with 0.018 part of pretreated vitamin B1, adding 0.36 part of pretreated glucose, mixing, adding 0.72 part of pretreated glucose, mixing, adding 1.5 parts of pretreated glucose, mixing, adding 3 parts of pretreated glucose, mixing, adding 6 parts of pretreated glucose, and mixing to obtain a third release material; mixing 0.12 part of pretreated glucose with 0.012 part of pretreated vitamin B2, then adding 0.24 part of pretreated glucose, mixing, then adding 0.48 part of pretreated glucose, mixing, then adding 1 part of pretreated glucose, mixing, then adding 2 parts of pretreated glucose, mixing, then adding 4 parts of pretreated glucose, mixing, then adding 8 parts of pretreated glucose, mixing to obtain a fourth release material; fifthly, mixing 0.003 part of pretreated glucose with 0.0003 part of pretreated vitamin D2, then adding 0.006 part of pretreated glucose for mixing, then adding 0.012 part of pretreated glucose for mixing, then adding 0.024 part of pretreated glucose for mixing, then adding 0.048 part of pretreated glucose for mixing, then adding 0.1 part of pretreated glucose for mixing, then adding 0.200 part of pretreated glucose for mixing, then adding 0.4 part of pretreated glucose for mixing, then adding 0.8 part of pretreated glucose for mixing, then adding 1.5 parts of pretreated glucose for mixing, then adding 3 parts of pretreated glucose for mixing, then adding 6 parts of pretreated glucose for mixing, and obtaining a quintupling release material; C. premixing: mixing 50 parts of pretreated glucose, a first time release material, a second time release material, a third time release material, a fourth time release material and a fifth time release material to obtain a mixed material; D. total mixing: and (3) putting the mixed material and the residual pretreated glucose into a two-dimensional motion mixer for mixing, and discharging to obtain the five-dimensional glucose.
The invention also discloses application of the five-vitamin glucose prepared by the preparation process of the five-vitamin glucose in preparing a medicament for treating digestive tract diseases.
The invention has the beneficial effects that:
the preparation process of the five-vitamin glucose provided by the invention prepares the five-vitamin glucose according to the process routes of pretreatment, release mixing, premixing and total mixing.
Specifically, the five double-release materials are obtained by weighing the materials according to a ratio, crushing, mixing the crushed glucose with vitamin B1, the crushed vitamin C, the crushed nicotinic acid, the crushed vitamin D2 and the crushed vitamin B2 by a double-release mixing method to obtain five double-release materials, then mixing the five double-release materials with the crushed glucose again to obtain a mixed material, and finally mixing the mixed material with the rest of the crushed glucose in a two-dimensional motion mixer again to obtain the product.
This application adopts doubly to release the mixing method and can fully mix five kinds of vitamins and glucose misce bene, mixes totally in premixing again, can be once more with each material misce bene. This application adopts above-mentioned mode can ensure to contact fully between each material in order to ensure the misce bene, improves the homogeneity that the material mixes. According to the general process route and the close matching among the steps, the aims of improving the uniformity of material mixing and ensuring the quality stability of the vitamins can be fulfilled.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The following provides a specific description of a preparation process and an application of pentavitamin glucose provided by an embodiment of the present invention.
The invention discloses a preparation process of five-dimensional glucose, which comprises the following steps: A. pretreatment: respectively taking 150 parts by weight of glucose, 0.012 part by weight of vitamin B2, 0.3 part by weight of vitamin C, 0.0003 part by weight of vitamin D2 and 0.15 part by weight of nicotinic acid, crushing and sieving to obtain pretreated glucose, pretreated vitamin C, pretreated nicotinic acid, pretreated vitamin D2 and pretreated vitamin B2; 0.018 portion of vitamin B1 is taken.
Thus the glucose is deposited in the air for a long time and easily absorbs moisture and influences the drug effect of final product, in this embodiment, glucose is dried in advance and is weighed again after moisture is less than 5%. In this example, in order to achieve a better mixing effect, glucose, vitamin C, niacin, vitamin D2, and vitamin B2 were all ground and passed through a 100-mesh sieve, and the drug effect was not sufficiently exhibited when the particle size was too large, and fly powder was easily caused when the particle size was too small.
B. Double release mixing: firstly, mixing 3 parts of pretreated glucose with 0.3 part of pretreated vitamin C, and then adding 6 parts of pretreated glucose for mixing to obtain a first time release material; mixing 1.5 parts of pretreated glucose with 0.15 part of pretreated nicotinic acid, then adding 3 parts of pretreated glucose for mixing, then adding 6 parts of pretreated glucose for mixing to obtain a second release material; ③ mixing 0.18 part of pretreated glucose with 0.018 part of vitamin B1, adding 0.36 part of pretreated glucose, mixing, adding 0.72 part of pretreated glucose, mixing, adding 1.5 parts of pretreated glucose, mixing, adding 3 parts of pretreated glucose, mixing, adding 6 parts of pretreated glucose, and mixing to obtain a third release material; mixing 0.12 part of pretreated glucose with 0.012 part of pretreated vitamin B2, then adding 0.24 part of pretreated glucose, mixing, then adding 0.48 part of pretreated glucose, mixing, then adding 1 part of pretreated glucose, mixing, then adding 2 parts of pretreated glucose, mixing, then adding 4 parts of pretreated glucose, mixing, then adding 8 parts of pretreated glucose, mixing to obtain a fourth release material; fifthly, 0.003 parts of pretreated glucose is mixed with 0.0003 parts of pretreated vitamin D2, then 0.006 parts of pretreated glucose is added and mixed, then 0.012 parts of pretreated glucose is added and mixed, then 0.024 parts of pretreated glucose is added and mixed, then 0.048 parts of pretreated glucose is added and mixed, then 0.1 parts of pretreated glucose is added and mixed, then 0.200 parts of pretreated glucose is added and mixed, then 0.4 parts of pretreated glucose is added and mixed, then 0.8 parts of pretreated glucose is added and mixed, then 1.5 parts of pretreated glucose is added and mixed, then 3 parts of pretreated glucose is added and mixed, then 6 parts of pretreated glucose is added and mixed, and a fifth-time release material is obtained. In this example, the double release mixing was performed in a stainless steel basin.
C. Premixing: mixing 50 parts of pretreated glucose, a first time release material, a second time release material, a third time release material, a fourth time release material and a fifth time release material to obtain a mixed material. In this example, the premixing was carried out by feeding the above materials into a trough mixer to make the mixing more uniform. In this example, the conditions of each release-doubling material were combined and mixed with 50 parts of pretreated glucose for 10 min.
D. Total mixing: and (3) putting the mixed material and the residual pretreated glucose into a two-dimensional motion mixer for mixing, and discharging to obtain the five-dimensional glucose. In this example, the materials were mixed in a two-dimensional motion mixer for a period of 60 min.
According to the preparation process of the embodiment, after the materials are crushed and sieved, the glucose is fully contacted with the vitamins by adopting the double-release mixing, then the pre-mixing is carried out between the double-release materials and the quantitative glucose, and then the mixed materials and the rest glucose are subjected to the total mixing. In the whole process, the glucose is mixed with each vitamin in a mode of releasing the glucose in times, so that the mixing uniformity of the glucose and each vitamin can be greatly increased, and meanwhile, the mixing uniformity among materials releasing in times can be greatly increased through premixing and total mixing. In the traditional preparation method, glucose is directly mixed with various vitamins, and because the addition amount of the glucose is very large, the phenomenon of uneven mixing of materials is easily caused by adopting the traditional method, so that the product quality is unstable. By adopting the preparation process provided by the embodiment, the uniformity of the material can be greatly improved, the stability of the product is improved, and the product quality is ensured.
Claims (7)
1. A preparation process of five-dimensional glucose is characterized by comprising the following steps:
A. pretreatment: respectively taking 150 parts by weight of glucose, 0.012 part by weight of vitamin B2, 0.3 part by weight of vitamin C, 0.0003 part by weight of vitamin D2 and 0.15 part by weight of nicotinic acid, crushing and sieving to obtain pretreated glucose, pretreated vitamin C, pretreated nicotinic acid, pretreated vitamin D2 and pretreated vitamin B2; 0.018 portion of vitamin B1 is taken for standby;
B. double release mixing:
mixing 3 parts of the pretreated glucose with 0.3 part of the pretreated vitamin C, and then adding 6 parts of the pretreated glucose for mixing to obtain a first time release material;
mixing 1.5 parts of the pretreated glucose with 0.15 part of the pretreated nicotinic acid, then adding 3 parts of the pretreated glucose, mixing, then adding 6 parts of the pretreated glucose, and mixing to obtain a second release material;
mixing 0.18 part of the pretreated glucose with 0.018 part of the vitamin B1, then adding 0.36 part of the pretreated glucose, mixing, then adding 0.72 part of the pretreated glucose, mixing, then adding 1.5 parts of the pretreated glucose, mixing, then adding 3 parts of the pretreated glucose, mixing, then adding 6 parts of the pretreated glucose, and mixing to obtain a third release material;
mixing 0.12 part of the pretreated glucose with 0.012 part of the pretreated vitamin B2, then adding 0.24 part of the pretreated glucose, mixing, then adding 0.48 part of the pretreated glucose, mixing, then adding 1 part of the pretreated glucose, mixing, then adding 2 parts of the pretreated glucose, mixing, then adding 4 parts of the pretreated glucose, mixing, then adding 8 parts of the pretreated glucose, and mixing to obtain a fourth release material;
mixing 0.003 part of the pretreated glucose with 0.0003 part of the pretreated vitamin D2, then adding 0.006 part of the pretreated glucose, mixing, then adding 0.012 part of the pretreated glucose, mixing, then adding 0.024 part of the pretreated glucose, then adding 0.048 part of the pretreated glucose, mixing, then adding 0.1 part of the pretreated glucose, mixing, then adding 0.200 part of the pretreated glucose, mixing, then adding 0.4 part of the pretreated glucose, mixing, then adding 0.8 part of the pretreated glucose, mixing, then adding 1.5 parts of the pretreated glucose, mixing, then adding 3 parts of the pretreated glucose, mixing, then 6 parts of the pretreated glucose, and obtaining a fifth-release material;
C. premixing: mixing 50 parts of the pretreated glucose, the first release-doubling material, the second release-doubling material, the third release-doubling material, the fourth release-doubling material and the fifth release-doubling material to obtain a mixed material;
D. total mixing: and (3) putting the mixed material and the rest of the pretreated glucose into a two-dimensional motion mixer for mixing, and discharging to obtain the five-dimensional glucose.
2. The process according to claim 1, wherein the moisture content of the glucose is less than 5%.
3. The process for preparing pentavitamin glucose in accordance with claim 2, wherein said glucose, said vitamin C, said niacin, said vitamin D2 and said vitamin B2 are all pulverized and sieved with a 100 mesh sieve.
4. The process for preparing five-dimensional glucose according to claim 1, wherein the mixing time of the premixing step is 10 min.
5. The process for preparing five-dimensional glucose according to claim 1, wherein the mixing time in the total mixing step is 60 min.
6. An application of the five-vitamin glucose prepared by the preparation process of the five-vitamin glucose in any one of the 1-5 in preparing a medicament for treating digestive tract diseases.
7. The use of claim 6, wherein the digestive tract disease comprises any one of chronic enteritis diarrhea, gastroenteritis, chronic gastritis, canker sore and gastric ulcer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010856800.9A CN114081891A (en) | 2020-08-24 | 2020-08-24 | Preparation process and application of five-vitamin glucose |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010856800.9A CN114081891A (en) | 2020-08-24 | 2020-08-24 | Preparation process and application of five-vitamin glucose |
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| Publication Number | Publication Date |
|---|---|
| CN114081891A true CN114081891A (en) | 2022-02-25 |
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| CN102429062A (en) * | 2011-11-23 | 2012-05-02 | 耿福能 | Preparation method of high-nutrition pellet-shaped tartary buckwheat tea |
| CN103479652A (en) * | 2012-11-21 | 2014-01-01 | 福州海王福药制药有限公司 | Children's four-vitamin calcium gluconate effervescent tablets and preparation method thereof |
| CN103284164A (en) * | 2013-06-08 | 2013-09-11 | 哈尔滨珍宝制药有限公司 | Composition comprising a plurality of vitamins and mineral substances |
| CN105010304A (en) * | 2014-04-23 | 2015-11-04 | 马乃祥 | Prescription composition of pig antiviral semen diluent |
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