CN114073789A

CN114073789A - Automatic-curing amorphous hydrogel pressure sore dressing and preparation method thereof

Info

Publication number: CN114073789A
Application number: CN202010829697.9A
Authority: CN
Inventors: 陈静
Original assignee: Union Hospital Tongji Medical College Huazhong University of Science and Technology
Current assignee: Union Hospital Tongji Medical College Huazhong University of Science and Technology
Priority date: 2020-08-18
Filing date: 2020-08-18
Publication date: 2022-02-22

Abstract

The invention discloses an automatic-curing amorphous hydrogel pressure sore dressing and a preparation method thereof, the dressing comprises a hydrogel matrix, a self-curing surrounding layer wrapping the hydrogel matrix and a sealing packaging film wrapping the self-curing surrounding layer in a sealing manner, the hydrogel matrix comprises an upper hydrogel matrix, a lower hydrogel matrix and an elastic reinforcing interlayer clamped and fixed between the upper hydrogel matrix and the lower hydrogel matrix, 10-80 parts of hydroxymethyl cellulose, 3-9 parts of chitosan, 1-4 parts of hydroxyethyl methacrylate, 5-20 parts of acrylic acid-2-hydroxyethyl ester, 5-160 parts of glycerol and 0.8-2 parts of preservative are adopted to construct a cellulose coupling colloid, deionized water is matched to construct the hydrogel matrix, acrylate microgel emulsion is used for realizing peripheral rapid curing, guar gum and hydrolyzed elastin are used for realizing internal reinforcing, the dressing has the advantages that a base material in the traditional hydrogel dressing is not needed any more, the whole body is not provided with a shaping structure before solidification, can be freely shaped according to the pressure sore wound surface, and has better skin adhesion and comfort.

Description

Automatic-curing amorphous hydrogel pressure sore dressing and preparation method thereof

Technical Field

The invention relates to the field of medical consumables, in particular to an automatic-curing amorphous hydrogel pressure sore dressing and a preparation method thereof.

Background

The pressure sore is caused by tissue ulceration and necrosis due to continuous ischemia, anoxia and malnutrition caused by long-term local tissue compression, and the skin injury is more easily caused by the loss of the self-regulation capability of muscles due to the complete or partial disappearance of consciousness of the body of an operation patient under the anesthesia condition, so that the chance of acute pressure sore in the operation is relatively increased. According to the estimation of national bedsore counseling group: 100 million people suffer from pressure sores only in the United states, 5.8 percent of Japanese hospitalized patients suffer from pressure sores, and the incidence rate of the pressure sores in hospitals is 3 to 14 percent. Paralytic patients and old patients are easy to suffer pressure sores due to long-term bed rest or long-time sitting on a wheelchair, long course of disease, malnutrition and low cell regeneration and repair capacity; once pressure sores occur, they can aggravate the condition of the patient, delay treatment, reduce the quality of life of the patient, increase treatment cost, and cause serious infection and death of the patient. About 6 million people die of pressure sore complications every year according to the reports of the relevant literatures. Skin pressure sores are a common problem in rehabilitation and nursing, ischemic changes can be generated in the underlying muscles after external pressure is applied to the skin for 2 hours, and pressure sores can also be generated after the same pressure is applied to the skin for 6 hours and the muscles are completely denatured, so that the pressure sores are generated after the skin pressure sores are pressed by medical instruments for a long time. Therefore, the prevention of pressure sores has very important medical significance.

Clinically, the prevention of pressure sores is realized by turning over, massaging and the like, and also by adopting an air cushion ring, a baking lamp, vaseline smearing and the like, but the air cushion ring is easy to block local blood circulation, so that venous congestion and edema simultaneously obstruct sweat evaporation to stimulate the skin, and particularly, the air cushion ring is not suitable for people suffering from edema and obesity; the skin is dried by using a baking lamp and the like, and the metabolism and oxygen demand of tissue cells are increased, so that the cells are ischemic and even necrotized; the product is applied to oily agent such as vaseline without gas permeability and respiratory function, and has low water evaporation amount far below that of normal skin, resulting in skin maceration.

When pressure sores occur, in addition to conventional nursing operations, dressing treatment needs to be carried out by adopting medical dressings, the medical dressings are medical products for skin injuries, and the past explanation of medical materials is as follows: "gauze, cotton ball and cotton pad, etc., used to clean or protect a wound, when treating a wound of a patient, it is necessary to cover the wound with a dressing after removing necrotic tissue to prevent bacterial invasion and control moisture loss. Nowadays, with the development of science and technology, people also provide new evaluation indexes for medical dressings: (1) ability to control and absorb exudates; (2) a bacteria barrier layer can be provided, a good environment suitable for tissue growth is created, and the tissue growth is promoted; (3) has suitable gas and water vapor permeability; (4) the use is convenient, and the tearing-off is easy; (5) no toxicity, harm and irritation; (6) has good mechanical properties.

The traditional medical dressing has the defects of tight coverage and poor air permeability, and along with the gradual permeation of the dressing padding on gauze, the gauze close to the skin can be gradually dried and causes friction to the pressure sore wound surface to cause wound surface damage and ulceration.

Disclosure of Invention

Technical problem to be solved

The invention aims to provide an automatic-curing amorphous hydrogel pressure sore dressing and a preparation method thereof, aiming at the defects that a medical adhesive tape is required to be used as a bearing substrate, irregular pressure sore parts need to be cut in advance before feeding, and effective close fitting cannot be realized in the prior art.

(II) technical scheme

In order to solve the technical problems that the medical adhesive tape is required to be used as a bearing substrate, the irregular pressure sore part needs to be cut in advance before feeding, and effective close fitting cannot be realized, the invention provides the following technical scheme:

an automatic-curing amorphous hydrogel pressure sore dressing comprises a hydrogel matrix, a self-curing surrounding layer and a sealing packaging film, wherein the self-curing surrounding layer is wrapped outside the hydrogel matrix;

the hydrogel matrix comprises the following components: 120-160 parts of hydrogel base material, 15-20 parts of silica gel particles and 3-6 parts of antibacterial component;

the self-curing surrounding layer comprises the following components: 25-30 parts of a hydrogel base material and 2-2.4 parts of an acrylate microgel emulsion;

the elastic reinforcing interlayer comprises the following components: 15-18 parts of a hydrogel base material, 4-7 parts of guar gum and 0.8-1 part of hydrolyzed elastin;

the hydrogel base material comprises cellulose coupling colloid and deionized water, wherein the volume ratio of the cellulose coupling colloid to the deionized water is 1: 5.2-2: 3.5, the cellulose coupling colloid comprises 10-80 parts of hydroxymethyl cellulose, 3-9 parts of chitosan, 1-4 parts of hydroxyethyl methacrylate, 5-20 parts of acrylic acid-2-hydroxyethyl ester, 5-160 parts of glycerol and 0.8-2 parts of a preservative.

Preferably, the antibacterial component comprises 2-4 parts of nano silver particles and 1-2 parts of chlorhexidine.

Preferably, the preservative is any one of parabens, benzoic acid and a salt thereof, and sorbic acid and a salt thereof.

Preferably, the molar ratio of the acrylate to the water in the acrylate microgel emulsion is 1: 1145.

a method of making an automatically-curing amorphous hydrogel pressure sore dressing comprising the steps of:

(1) pressing and kneading the hydroxymethyl cellulose with 50% shear strain for later use, heating the water environment to 75 ℃, maintaining the vibration frequency of 3.5Hz, adding the hydroxymethyl cellulose subjected to the pressing and tanning pretreatment, keeping the temperature for vibration treatment for 350s, and finishing the disentanglement of the hydroxymethyl cellulose;

(2) stirring hydroxyethyl methacrylate and 2-hydroxyethyl acrylate in water environment at the rotating speed of 1200r/min for 10min, mixing, heating to 45.5 ℃, keeping stirring, and performing copolymerization reaction for 20min to obtain a primary coupling agent;

(3) naturally mixing the hydroxymethyl cellulose disentangled in the water environment in the step (1) and the primary coupling agent product in the step (2) in the water environment, adding chitosan, fully stirring and mixing, and introducing glycerol at the bottom of the liquid phase environment;

(4) continuously introducing nitrogen into the liquid phase environment of the mixed product in the step (3) for 10min at the air pressure of 3MPa, and removing oxygen dissolved in the liquid phase environment by using a bubbling method to obtain an oxygen-free environment;

(5) performing high-energy radiation irradiation on the liquid-phase product subjected to deoxidation in the step (4) to realize coupling reaction, wherein gamma rays or electron beams are adopted, the electron beams are generated by an accelerator and have energy above MEV, the gamma rays are preferably 60 Co-gamma rays or 137 Cs-gamma rays, and the radiation dose is preferably 1 x 10³～1*10⁶Gy, the radiation time is 10h, and the reaction temperature is-63 to-95 ℃ during radiation;

(6) heating the product after the illumination coupling to room temperature, adding any one of hydroxybenzoic acid esters, benzoic acid and salts thereof, sorbic acid and salts thereof as a preservative and nano silver particles and chlorhexidine as an antibacterial component, fully mixing, and standing for 5min to complete solidification;

(7) preparing an elastic reinforcing interlayer, heating the product obtained in the step (5) to room temperature, adding guar gum, and fully stirring and uniformly mixing at the rotating speed of 700r/min for later use;

(8) maintaining the vibration frequency of 2.5Hz in a water environment at 25 ℃, adding the hydrolyzed elastin for vibration treatment for 100s to complete the disentanglement of the hydrolyzed elastin, injecting the disentangled hydrolyzed elastin into the liquid-phase product in the step (7) in a glue dispensing mode at the uniform distance of 4mm, and standing for 10min to complete solidification;

(9) shaping the product cured in the step (6) into an upper hydrogel matrix and a lower hydrogel matrix, shaping the product cured in the step (8) into an elastic reinforcing interlayer, and constructing a stable interlayer structure of the upper hydrogel matrix, the elastic reinforcing interlayer and the lower hydrogel matrix;

(10) preparing a self-curing surrounding layer, heating the product obtained in the step (5) to room temperature, mixing the product with the acrylate microgel emulsion, stirring the mixture for 30s at the rotating speed of 1300r/min, quickly coating the mixture on the stable interlayer structure prepared in the step (9), immediately coating a sealing packaging film, and finishing the beneficial effects of the preparation (III) of the self-curing amorphous hydrogel pressure sore dressing

Compared with the prior art, the invention provides an automatically-cured amorphous hydrogel pressure sore dressing and a preparation method thereof, and the dressing has the following beneficial effects:

(1) the upper hydrogel matrix, the lower hydrogel matrix and the elastic reinforcing interlayer clamped between the upper hydrogel matrix and the lower hydrogel matrix form a composite structure, wherein hydrolyzed elastin in the elastic reinforcing interlayer is used as an elastic supporting framework to improve the overall strength, and meanwhile, guar gum is used as an adhesive to fix the hydrolyzed elastin and the hydrogel base material to form a high-strength stable structure;

(2) the hydrogel substrate and the acrylate microgel emulsion are mixed to form the self-curing surrounding layer, the acrylate microgel emulsion can be rapidly cured when meeting an oxidizing environment, the surface which is not in contact with the skin can be rapidly cured to form a cured resin surface similar to rubber texture after the sealing packaging film is uncovered and the acrylate microgel emulsion is plastic according to requirements, and the effect of fixing the surface of the wound of the pressure sore is achieved.

Drawings

FIG. 1 is a table showing comparative variables, compressive strengths, tensile strengths and curing rates in examples 1 to 4 of the automatically-cured amorphous hydrogel pressure sore dressing and the preparation method thereof according to the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "axial," "radial," "circumferential," and the like are used in the indicated orientations and positional relationships based on the drawings for convenience in describing and simplifying the description, but do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the invention.

In the present invention, unless otherwise specifically stated or limited, the terms "mounted," "connected," "fixed," and the like are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally formed; the connection can be mechanical connection, electrical connection or communication connection; either directly or indirectly through intervening media, either internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

The technical solution of the present invention will be described in detail below with specific examples. The following several specific embodiments may be combined with each other, and details of the same or similar concepts or processes may not be repeated in some embodiments.

An automatic cured amorphous hydrogel pressure sore dressing comprises a hydrogel matrix, a self-curing surrounding layer and a sealing packaging film, wherein the self-curing surrounding layer is wrapped outside the hydrogel matrix; the dressing is a sandwich structure with an outer wrapping structure, the upper hydrogel matrix and the lower hydrogel matrix ensure that the whole dressing has sufficient elasticity, moisture absorption performance and air permeability, wherein the elastic reinforcing interlayer comprises the following components: 15-18 parts of hydrogel base material, 4-7 parts of guar gum, 0.8-1 part of hydrolyzed elastin, an upper hydrogel matrix, a lower hydrogel matrix and an elastic reinforcing interlayer clamped between the upper hydrogel matrix and the lower hydrogel matrix form a composite structure, wherein the hydrolyzed elastin in the elastic reinforcing interlayer is used as an elastic supporting framework to improve the overall strength, and meanwhile, guar gum is used as an adhesive to fix the hydrolyzed elastin and the hydrogel base material to form a high-strength stable structure; the self-curing envelope layer comprises the following components: 25-30 parts of hydrogel base material, 2-2.4 parts of acrylate microgel emulsion, wherein the gel base material and the acrylate microgel emulsion are mixed to form a self-curing surrounding layer, the acrylate microgel emulsion can be rapidly cured when meeting an oxidizing environment, and after a sealing packaging film is uncovered and plasticity is required, the surface which is not in contact with the skin can be rapidly cured to form a cured resin surface similar to rubber texture, so that the effect of fixing the surface of a pressure sore wound is achieved. The molar ratio of the acrylic ester to the water in the acrylic ester microgel emulsion is 1: 1145, adopting a molar ratio of acrylate to water of 1: 900,1: 1000,1: 1144,1: 1145,1: 1146 and 1: 1200 five control test self-curing envelopes were made and tested for ultimate elongation at break, yielding 373.1%, 344.7%, 297.2%, 289.3%, 294.8% and 326.5% in that order, thus showing a 1: 1145 the self-curing envelope is best cured.

The hydrogel matrix comprises the following components: 120-160 parts of hydrogel base material, 15-20 parts of silica gel particles and 3-6 parts of antibacterial component, wherein the hydrogel base material comprises cellulose coupling colloid and deionized water, and the volume ratio of the cellulose coupling colloid to the deionized water is 1: 5.2-2: 3.5, the cellulose coupling colloid comprises 10-80 parts of hydroxymethyl cellulose, 3-9 parts of chitosan, 1-4 parts of hydroxyethyl methacrylate, 5-20 parts of acrylic acid-2-hydroxyethyl ester, 5-160 parts of glycerol and 0.8-2 parts of a preservative. Hydroxyethyl methacrylate is obtained by the reaction of ethylene oxide and methacrylic acid, often referred to as HEMA for short, and is used for manufacturing acrylic resin containing active hydroxyl in the plastic industry, the hydroxyethyl methacrylate and 2-hydroxyethyl acrylate are matched to be used as a primary coupling agent, and the hydroxyethyl methacrylate can catalyze the 2-hydroxyethyl acrylate to generate active hydroxyl, so that the subsequent illumination coupling reaction with hydroxymethyl cellulose can generate as many coupling bonds as possible, and the coupling curing effect is better.

The hydrogel substrate was tested for tensile strength, taking a hydrogel substrate with dimensions of 8cm in length, 2cm in width, 0, 8cm in thickness, and performing a bilateral clamping tensile elongation test in comparison with a comparative material prepared by simply adding 2-hydroxyethyl acrylate as a coupling agent, in which the ultimate elongation at break of the hydrogel substrate was 1479.6%, while the ultimate elongation at break of the comparative material prepared by simply adding 2-hydroxyethyl acrylate as a coupling agent was 1215.1%.

The antibacterial component comprises 2-4 parts of nano silver particles and 1-2 parts of chlorhexidine. The nano silver particles are traditional antibacterial components, however, seepage and bleeding are common conditions in the use environment of pressure sore wound surfaces, when the seeped blood enters the automatic curing amorphous hydrogel pressure sore dressing, if only the nano silver particles are used as the antibacterial components, the blood can cause coating pollution on the particle surfaces of the nano silver particles, and the subsequent antibacterial performance is reduced. The chlorhexidine has quite strong broad-spectrum bacteriostasis and sterilization effects, is a better sterilization disinfectant, has stronger antibacterial effects on gram-positive bacteria and gram-negative bacteria than disinfectant such as benzalkonium bromide and the like, is effective even in the presence of serum, blood and the like, and can be used for supplementing antibacterial performance under the condition of larger blood seepage.

The staining smear counting method in the quoted bacteria number determination method comprises replacing slide carrier with active composite skin during designing test, taking two 10 × 10cm active composite skins, adopting hydrogel matrix containing nano silver particles and chlorhexidine and control group hydrogel matrix only mixed with nano silver particles, respectively embedding capillary tube communicating active composite skin surface and blood sac under active composite skin, breaking 5 × 5cm rough damaged area on active composite skin surface and coating 100cfu/cm rough damaged area²After the staphylococcus aureus solution is coated, a hydrogel matrix and a control group hydrogel matrix are respectively and tightly covered on two 10 x 10cm active composite skins, capillary tubes keep slow bleeding during the process, the hydrogel matrix and the control group hydrogel matrix are uncovered after the two active composite skins are placed for 120min in a room-temperature and normal-oxygen environment, two active composite skins are respectively swabbed and sampled, four common nutrient agar plates in an equivalent environment are taken, two swabbed samples are respectively diluted in a ten-fold increasing manner for three times, 1/100 diluted samples and 1/1000 diluted samples are respectively coated on the common nutrient agar plates, the total number of colonies is observed after the two active composite skins are cultured for 48 hours in a normal-oxygen environment at 37 ℃, and the total number of the colonies is 82cfu/cm after the culture is carried out by adopting 1/100 diluted samples of the hydrogel matrix ²1/1000 Total number of colonies after dilution culture was 9cfu/cm²The total number of colonies after 1/100 dilution culture using the hydrogel matrix of the control group was 117cfu/cm ²1/1000 thinThe total number of colonies after sample release culture was 13cfu/cm²Therefore, the addition of chlorhexidine can effectively improve the antibacterial effect of the self-curing amorphous hydrogel pressure sore dressing in the wound surface environment of blood seepage.

The antiseptic is any one of parabens, benzoic acid and its salt, and sorbic acid and its salt.

The specific implementation mode during the preparation is as follows:

example 1: a method of making an automatically-curing amorphous hydrogel pressure sore dressing comprising the steps of:

(5) performing high-energy radiation irradiation on the liquid-phase product subjected to deoxidation in the step (4) to realize coupling reaction, wherein 60 Co-gamma rays are adopted, and the radiation dose is 1 × 10³Gy, the radiation time is 10h, and the reaction temperature is-65 ℃ during radiation;

(10) and (3) preparing a self-curing surrounding layer, heating the product obtained in the step (5) to room temperature, mixing the product with the acrylate microgel emulsion, stirring the mixture at the rotating speed of 1300r/min for 30s, quickly coating the mixture on the stable interlayer structure prepared in the step (9), and immediately coating a sealing packaging film to finish the preparation of the self-curing amorphous hydrogel pressure sore dressing.

Example 2: a method of making an automatically-curing amorphous hydrogel pressure sore dressing comprising the steps of:

(5) performing high-energy radiation irradiation on the liquid-phase product subjected to deoxidation in the step (4) to realize coupling reaction, wherein a high-energy electron beam which is generated by an accelerator and has energy above MEV is adopted, the irradiation time is 10 hours, and the reaction temperature is-82 ℃ during irradiation;

Example 3: a method of making an automatically-curing amorphous hydrogel pressure sore dressing comprising the steps of:

(5) performing high-energy radiation irradiation on the liquid-phase product subjected to deoxidation in the step (4) to realize coupling reaction, wherein 137 Cs-gamma rays are adopted, and the radiation dose is preferably 1 x 10⁶Gy, the radiation time is 10h, and the reaction temperature is-95 ℃ during radiation;

Example 4: a method of making an automatically-curing amorphous hydrogel pressure sore dressing comprising the steps of:

(5) heating the liquid-phase product subjected to deoxidation in the step (4) to 85 ℃, and keeping a sealed state for water bath reaction for 300 min;

(6) cooling the product after the water bath reaction to room temperature in a cold water bath, adding any one of hydroxybenzoic acid esters, benzoic acid and salts thereof, sorbic acid and salts thereof as a preservative and nano silver particles and chlorhexidine as an antibacterial component, fully mixing, and standing for 5min to finish solidification;

Three sets of 10 x 1cm standard size samples were prepared for use in each of the four example protocols.

Test 1: preparing an environment with the humidity of 60% at normal temperature and normal pressure, taking four groups of samples with standard sizes according to the scheme of the embodiment, tearing off a sealing packaging film, comparing the curing time, wherein the curing time is 66s, 53s, 38s and 79s in sequence, performing a crushing test of pressing in the vertical direction by using an HY-01 electronic compression tester after curing is completed, and measuring the ultimate compressive strength of each group of samples to be 18.8MPa, 20.4MPa, 22.3MPa and 16.2MPa in sequence.

And (3) testing 2: preparing an environment with the humidity of 60% at normal temperature and normal pressure, taking one part of each of four groups of standard-size samples in the scheme of the embodiment, tearing off a sealing packaging film, waiting for the solidification of each sample, and performing a tensile fracture test of bilateral clamping to obtain the ultimate tensile elongation of 1363.5%, 1325.6%, 1288.1% and 1431.1% in sequence.

And (3) testing: preparing an environment with the humidity of 60% at normal temperature and normal pressure, taking the outer convex wound surface of the joint simulated by the bent active composite skin of the bracket, taking one part of each of the four groups of samples with standard sizes according to the scheme of the embodiment, tearing off the sealing packaging film, and observing the setting time for 71s, 64s, 45s and 91s in sequence.

The parameters of the comparison test 1, the comparison test 2 and the comparison test 3 show that under the condition of the same formula, the higher the radiation level intensity adopted by the light coupling reaction is, the higher the connection intensity of the coupling bond is, so that the shorter the curing time is, the stronger the rigidity of the structural strength is, therefore, the strength of the obtained product can be adjusted by adjusting the radiation level according to the actual practical requirement, and the water bath reaction group is used as the contrast reference group to have the advantage of the light coupling reaction at the reaction part.

In the present invention, unless otherwise explicitly specified or limited, the first feature "on" or "under" the second feature may be directly contacting the first feature and the second feature or indirectly contacting the first feature and the second feature through an intermediate. Also, a first feature "on," "above," and "over" a second feature may mean that the first feature is directly above or obliquely above the second feature, or that only the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lower level than the second feature. In the description herein, reference to the description of the term "one embodiment," "some embodiments," "an example," "a specific example" or "some examples," or the like, means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example.

Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A self-curing amorphous hydrogel pressure wound dressing, characterized in that: comprising a hydrogel matrix, a self-curing envelope layer wrapped outside the hydrogel matrix and a sealing packaging film that seals and wraps the self-curing envelope layer , the hydrogel matrix comprises an upper hydrogel matrix, a lower hydrogel matrix and an elastic reinforcing interlayer clamped and fixed between the upper hydrogel matrix and the lower hydrogel matrix;

The hydrogel matrix includes the following components: 120-160 parts of hydrogel base material, 15-20 parts of silica gel particles, and 3-6 parts of antibacterial components;

The self-curing surrounding layer includes the following components: 25-30 parts of a hydrogel base material, and 2-2.4 parts of an acrylate microgel emulsion;

The elastic reinforcing interlayer includes the following components: 15-18 parts of hydrogel base material, 4-7 parts of guar gum, and 0.8-1 part of hydrolyzed elastin;

The hydrogel base material includes cellulose coupled colloid and deionized water, the volume ratio of the cellulose coupled colloid and deionized water is 1:5.2-2:3.5, and the cellulose coupled colloid includes hydroxyl 10-80 parts of methyl cellulose, 3-9 parts of chitosan, 1-4 parts of hydroxyethyl methacrylate, 5-20 parts of 2-hydroxyethyl acrylate, 5-160 parts of glycerin and 0.8 parts of preservative ~ 2 servings.

2 . The self-curing amorphous hydrogel pressure ulcer dressing according to claim 1 , wherein the antibacterial component comprises 2-4 parts of nano-silver particles and 1-2 parts of diclofenac. 3 . share.

3. A kind of self-curing amorphous hydrogel pressure ulcer dressing according to claim 1, characterized in that: the preservatives are parabens, benzoic acid and salts thereof, sorbic acid and salts thereof any of the.

4 . The self-curing amorphous hydrogel pressure wound dressing according to claim 1 , wherein the molar ratio of acrylate to water in the acrylate microgel emulsion is 1:1145. 5 .

5. The preparation method for preparing a self-curing amorphous hydrogel pressure ulcer dressing as claimed in claims 1 to 4, characterized in that: comprising the following steps:

(1) After pressing and kneading hydroxymethyl cellulose with 50% shear strain, the water environment is heated to 75 ° C, maintaining the vibration frequency of 3.5 Hz, adding the hydroxymethyl cellulose after pressing and tanning, and maintaining the temperature and vibration treatment 350s to complete the disentanglement of hydroxymethyl cellulose;

(2) Hydroxyethyl methacrylate and 2-hydroxyethyl acrylate were mixed in a water environment at a rotational speed of 1200 r/min for 10 minutes, then heated to 45.5 ° C, kept stirring, and the copolymerization reaction was carried out for 20 minutes to obtain a primary coupling agent;

(3) The hydroxymethyl cellulose disentangled in the water environment in the step (1) and the first-stage coupling agent product in the step (2) are naturally mixed in the water environment, and then chitosan is added, and after fully stirring and mixing Passing glycerol at the bottom of the liquid phase environment;

(4) continue to feed nitrogen into the liquid phase environment of the mixed product in step (3) with a pressure of 3MPa for 10min, utilize bubbling method to remove the oxygen dissolved in the liquid phase environment, and obtain an oxygen-free environment;

(5) High-energy radiation irradiation is performed on the liquid-phase product deoxidized in the step (4) to realize the coupling reaction, and γ rays or electron beams are used here. The electron beams are generated by an accelerator and have an energy above MEV, and the γ rays are preferably 60Co-γ ray or 137Cs-γ ray, the radiation dose is preferably 1*10 ³ ～ 1*10 ⁶ Gy, the irradiation time is 10h, and the reaction temperature during irradiation is -63°C～-95°C;

(6) the product after photocoupling is warmed up to room temperature, adds any one in hydroxybenzoic acid esters, benzoic acid and its salt, sorbic acid and its salt as preservatives and nano-silver particles and diclofenac Alkane is used as an antibacterial component, and it is fully mixed and left to stand for 5 minutes to complete curing;

(7) preparing elastic reinforced interlayer, heating the product obtained in step (5) to room temperature, adding guar gum, fully stirring and mixing at a rotating speed of 700r/min for subsequent use;

(8) The water environment is maintained at a vibration frequency of 2.5 Hz at 25 °C, and the hydrolyzed elastin is added to vibrate for 100 s to complete the disentanglement of the hydrolyzed elastin. After injecting the liquid phase product of step (7), leave standstill for 10min to complete curing;

(9) the product cured in step (6) is shaped into an upper hydrogel matrix and a lower hydrogel matrix, the cured product in step (8) is shaped into an elastic reinforced interlayer, and an upper hydrogel matrix is constructed, elastic Stable sandwich structure of reinforcement sandwich and lower hydrogel matrix;

(10) preparing the self-curing envelope layer, heating the product obtained in step (5) to room temperature, mixing into the acrylate microgel emulsion, stirring at a rotational speed of 1300r/min for 30s, and quickly coating it in step (9) to obtain The stable sandwich structure was immediately wrapped with a sealing packaging film to complete the preparation of the self-curing amorphous hydrogel pressure ulcer dressing.